Contents: February 2000, Volume 44, Issue 2        Susceptibility        Experimental Therapeutics        Pharmacology        Mechanisms of Resistance        Clinical Therapeutics        Mechanisms of Action        Chemistry; Biosynthesis        Antiviral Agents        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Susceptibility:

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Correlation between the Resistance Genotype Determined by Multiplex PCR Assays and the Antibiotic Susceptibility Patterns of Staphylococcus aureus and Staphylococcus epidermidis Francis Martineau, François J. Picard, Nicolas Lansac, Christian Ménard, Paul H. Roy, Marc Ouellette, and Michel G. Bergeron Antimicrob. Agents Chemother. February 2000 44: 231-238; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Three Methods of Determining MICs for Filamentous Fungi Using Different End Point Criteria and Incubation Periods C. Llop, I. Pujol, C. Aguilar, J. Sala, D. Riba, and J. Guarro Antimicrob. Agents Chemother. February 2000 44: 239-242; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Helicobacter pylori Uptake and Efflux: Basis for Intrinsic Susceptibility to Antibiotics In Vitro J. E. Bina, R. A. Alm, M. Uria-Nickelsen, S. R. Thomas, T. J. Trust, and R. E. W. Hancock Antimicrob. Agents Chemother. February 2000 44: 248-254; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Antimicrobial Activities of the Newly Synthesized Quinolone WQ-3034, Levofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis and Mycobacterium avium Complex Haruaki Tomioka, Katsumasa Sato, Hiroko Kajitani, Tatsuya Akaki, and Shinji Shishido Antimicrob. Agents Chemother. February 2000 44: 283-286; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antipneumococcal Activities of Gemifloxacin Compared to Those of Nine Other Agents Todd A. Davies, Linda M. Kelly, Glenn A. Pankuch, Kim L. Credito, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. February 2000 44: 304-310; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Shaking on Antifungal Susceptibility Testing of Cryptococcus neoformans: a Comparison of the NCCLS Standard M27A Medium, Buffered Yeast Nitrogen Base, and RPMI-2% Glucose Juan L. Rodríguez-Tudela, Francisco Martín-Díez, Manuel Cuenca-Estrella, Laura Rodero, Yolanda Carpintero, and Begoña Gorgojo Antimicrob. Agents Chemother. February 2000 44: 400-404; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of the New Triazole BMS-207147 against Aspergillus Species in Comparison with Itraconazole and Amphotericin B Caroline B. Moore, Caroline M. Walls, and David W. Denning Antimicrob. Agents Chemother. February 2000 44: 441-443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of ABT-773, a New Ketolide, against Recent Clinical Isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Angela B. Brueggemann, Gary V. Doern, Holly K. Huynh, Elizabeth M. Wingert, and Paul R. Rhomberg Antimicrob. Agents Chemother. February 2000 44: 447-449; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance to Mercury and Antimicrobial Agents in Streptococcus mutans Isolates from Human Subjects in Relation to Exposure to Dental Amalgam Fillings Jorma Leistevuo, Helinä Järvinen, Monica Österblad, Tiina Leistevuo, Pentti Huovinen, and Jorma Tenovuo Antimicrob. Agents Chemother. February 2000 44: 456-457; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Rabeprazole, a Novel Proton Pump Inhibitor, and Its Thioether Derivative Alone and in Combination with Other Antimicrobials against Recent Clinical Isolates of Helicobacter pylori Yoshiyuki Kawakami, Takayuki Akahane, Masaru Yamaguchi, Kozue Oana, Yuko Takahashi, Yukie Okimura, Tadashi Okabe, Akira Gotoh, and Tsutomu Katsuyama Antimicrob. Agents Chemother. February 2000 44: 458-461; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Ketoconazole, Econazole, Miconazole, and Melaleuca alternifolia (Tea Tree) Oil against Malassezia Species K. A. Hammer, C. F. Carson, and T. V. Riley Antimicrob. Agents Chemother. February 2000 44: 467-469; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans Joseph Meletiadis, Johan W. Mouton, Juan L. Rodriguez-Tudela, Jacques F. G. M. Meis, and Paul E. Verweij Antimicrob. Agents Chemother. February 2000 44: 470-472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Immunization with the Candida albicans Membrane Fraction and in Combination with Fluconazole Protects against Systemic Fungal Infections Shigetoshi Mizutani, Masahiro Endo, Toshiaki Ino-ue, Masahiro Kurasawa, Yoko Uno, Hideharu Saito, Ikunoshin Kato, and Kazutoh Takesako Antimicrob. Agents Chemother. February 2000 44: 243-247; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of a New Cream Formulation of Mupirocin: Comparison with Oral and Topical Agents in Experimental Skin Infections John Gisby and Joanna Bryant Antimicrob. Agents Chemother. February 2000 44: 255-260; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Toxicity of LY303366, an Echinocandin Antifungal, in Mice Pretreated with Glucocorticoids Karl V. Clemons, Raymond A. Sobel, and David A. Stevens Antimicrob. Agents Chemother. February 2000 44: 378-381; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium-Deficient Diet Mehdi Shakibaei, Kerstin Pfister, Rudolf Schwabe, Jürgen Vormann, and Ralf Stahlmann Antimicrob. Agents Chemother. February 2000 44: 261-266; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Population Pharmacokinetic Model for Vancomycin in Pediatric Patients and Its Predictive Value in a Naive Population Patrice Lamarre, Denis Lebel, and Murray P. Ducharme Antimicrob. Agents Chemother. February 2000 44: 278-282; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Lipid Formulations of Amphotericin B into Bone Marrow and Fat Tissue in Rabbits Andreas H. Groll, Diana Mickiene, Stephen C. Piscitelli, and Thomas J. Walsh Antimicrob. Agents Chemother. February 2000 44: 408-410; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Antibiotic Resistance in Campylobacter Strains Isolated from Animals, Foods, and Humans in Spain in 1997-1998 Yolanda Sáenz, Myriam Zarazaga, Marta Lantero, M. José Gastañares, Fernando Baquero, and Carmen Torres Antimicrob. Agents Chemother. February 2000 44: 267-271; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reversion of the Glycopeptide Resistance Phenotype in Staphylococcus aureus Clinical Isolates Susan Boyle-Vavra, Sarah K. Berke, Jean C. Lee, and Robert S. Daum Antimicrob. Agents Chemother. February 2000 44: 272-277; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Antibiotic Resistance in Stenotrophomonas maltophilia: Involvement of a Multidrug Efflux System Li Zhang, Xian-Zhi Li, and Keith Poole Antimicrob. Agents Chemother. February 2000 44: 287-293; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Passage-Selected Vancomycin-Resistant Staphylococcus aureus Strains of Diverse Parental Backgrounds Richard F. Pfeltz, Vineet K. Singh, Jennifer L. Schmidt, Michael A. Batten, Christopher S. Baranyk, Matthew J. Nadakavukaren, Radheshyam K. Jayaswal, and Brian J. Wilkinson Antimicrob. Agents Chemother. February 2000 44: 294-303; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Substitutions in the Eyelet Region Disrupt Cefepime Diffusion through the Escherichia coli OmpF Channel Valérie Simonet, Monique Malléa, and Jean-Marie Pagès Antimicrob. Agents Chemother. February 2000 44: 311-315; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Engineering the Specificity of Antibacterial Fluoroquinolones: Benzenesulfonamide Modifications at C-7 of Ciprofloxacin Change Its Primary Target in Streptococcus pneumoniae from Topoisomerase IV to Gyrase Fabiana L. Alovero, Xiao-Su Pan, Julia E. Morris, Ruben H. Manzo, and L. Mark Fisher Antimicrob. Agents Chemother. February 2000 44: 320-325; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Genetic Analysis of Nucleotide Polymorphisms Associated with Ethambutol Resistance in Human Isolates of Mycobacterium tuberculosis Srinivas V. Ramaswamy, Amol G. Amin, Servet Göksel, Charles E. Stager, Shu-Jun Dou, Hana El Sahly, Soraya L. Moghazeh, Barry N. Kreiswirth, and James M. Musser Antimicrob. Agents Chemother. February 2000 44: 326-336; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Artemisinin Resistance in the Rodent Malaria Pathogen Plasmodium yoelii Daniel J. Walker, Jessica L. Pitsch, Michael M. Peng, Brian L. Robinson, Wallace Peters, Jamaree Bhisutthibhan, and Steven R. Meshnick Antimicrob. Agents Chemother. February 2000 44: 344-347; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Gene Cassettes for Trimethoprim Resistance, dfr13, and Streptomycin-Spectinomycin Resistance, aadA4, Inserted on a Class 1 Integron Peter V. Adrian, Christopher J. Thomson, Keith P. Klugman, and Sebastian G. B. Amyes Antimicrob. Agents Chemother. February 2000 44: 355-361; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Level Expression of Chromosomally Encoded SHV-1 -Lactamase and an Outer Membrane Protein Change Confer Resistance to Ceftazidime and Piperacillin- Tazobactam in a Clinical Isolate of Klebsiella pneumoniae Louis B. Rice, Lenore L. Carias, Andrea M. Hujer, Mary Bonafede, Rebecca Hutton, Claudia Hoyen, and Robert A. Bonomo Antimicrob. Agents Chemother. February 2000 44: 362-367; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Acquisition of Chloramphenicol Resistance by the Linearization and Integration of the Entire Staphylococcal Plasmid pC194 into the Chromosome of Streptococcus pneumoniae Carol A. Widdowson, Peter V. Adrian, and Keith P. Klugman Antimicrob. Agents Chemother. February 2000 44: 393-395; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Macrolide-Lincosamide-Streptogramin B Resistance Determinant from Clostridium difficile 630 Contains Two erm(B) Genes Kylie A. Farrow, Dena Lyras, and Julian I. Rood Antimicrob. Agents Chemother. February 2000 44: 411-413; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Development of Resistance to Telithromycin (HMR 3647), Four Macrolides, Clindamycin, and Pristinamycin in Streptococcus pneumoniae Todd A. Davies, Bonifacio E. Dewasse, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. February 2000 44: 414-417; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Florfenicol Resistance Genes in Escherichia coli Isolated from Sick Chickens Kathleen Keyes, Charlene Hudson, John J. Maurer, Stephan Thayer, David G. White, and Margie D. Lee Antimicrob. Agents Chemother. February 2000 44: 421-424; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cloning, Nucleotide Sequencing, and Analysis of the Gene Encoding an AmpC -Lactamase in Acinetobacter baumannii Germán Bou and Jesús Martínez-Beltrán Antimicrob. Agents Chemother. February 2000 44: 428-432; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance to Quinupristin-Dalfopristin among Isolates of Enterococcus faecium from Animals, Raw Meat, and Hospital Patients in Western Europe Mehnam Soltani, David Beighton, John Philpott-Howard, and Neil Woodford Antimicrob. Agents Chemother. February 2000 44: 433-436; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Characterization of the Point Mutation Which Affects the Transcription Level of the Chromosomal 3-N-Acetyltransferase Gene of Streptomyces griseus SS-1198 Jun Ishikawa, Atsuko Sunada, Ritsuko Oyama, and Kunimoto Hotta Antimicrob. Agents Chemother. February 2000 44: 437-440; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of the -Lactamases from Clinical Isolates of Moraxella (Branhamella) catarrhalis Obtained from 24 U.S. Medical Centers during 1994-1995 and 1997-1998 Sandra S. Richter, Patricia L. Winokur, Angela B. Brueggemann, Holly K. Huynh, Paul R. Rhomberg, Elizabeth M. Wingert, and Gary V. Doern Antimicrob. Agents Chemother. February 2000 44: 444-446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of TEM-56, a Novel -Lactamase Produced by a Klebsiella pneumoniae Clinical Isolate Catherine Neuwirth, Roger Labia, Eliane Siebor, Andre Pechinot, Stephanie Madec, El Bachir Chaibi, and Antoine Kazmierczak Antimicrob. Agents Chemother. February 2000 44: 453-455; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of gyrA, gyrB, parC, and parE Mutations in Clinical Isolates of Streptococcus pneumoniae with Decreased Susceptibilities to Different Fluoroquinolones and Originating from Worldwide Surveillance Studies during the 1997-1998 Respiratory Season Mark E. Jones, Daniel F. Sahm, Nele Martin, Sibylle Scheuring, Peter Heisig, Clyde Thornsberry, Karl Köhrer, and Franz-Josef Schmitz Antimicrob. Agents Chemother. February 2000 44: 462-466; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Regional Prophylaxis with Teicoplanin in Monolateral or Bilateral Total Knee Replacement: an Open Study Fausto de Lalla, Renato Viola, Giampietro Pellizzer, Luca Lazzarini, Andrea Tramarin, and Paolo Fabris Antimicrob. Agents Chemother. February 2000 44: 316-319; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of the Cyclodextrin Liquid Preparation of Itraconazole in Treatment of Denture Stomatitis: Comparison with Itraconazole Capsules L. J. Cross, J. Bagg, and T. C. Aitchison Antimicrob. Agents Chemother. February 2000 44: 425-427; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Failure of Short-Course Ceftriaxone Chemotherapy for Multidrug-Resistant Typhoid Fever in Children: a Randomized Controlled Trial in Pakistan Zulfiqar A. Bhutta, Iqtidar A. Khan, and Mamoon Shadmani Antimicrob. Agents Chemother. February 2000 44: 450-452; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Effect of a Bis-Benzyl Polyamine Analogue on Pneumocystis carinii Salim Merali, Kevin Chin, and Allen B. Clarkson, Jr. Antimicrob. Agents Chemother. February 2000 44: 337-343; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Candida albicans Mutants Deficient in Respiration Are Resistant to the Small Cationic Salivary Antimicrobial Peptide Histatin 5 Csilla Gyurko, Urs Lendenmann, Robert F. Troxler, and Frank G. Oppenheim Antimicrob. Agents Chemother. February 2000 44: 348-354; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discovery of Novel Antifungal (1,3)--D-Glucan Synthase Inhibitors J. Onishi, M. Meinz, J. Thompson, J. Curotto, S. Dreikorn, M. Rosenbach, C. Douglas, G. Abruzzo, A. Flattery, L. Kong, A. Cabello, F. Vicente, F. Pelaez, M. T. Diez, I. Martin, G. Bills, R. Giacobbe, A. Dombrowski, R. Schwartz, S. Morris, G. Harris, A. Tsipouras, K. Wilson, and M. B. Kurtz Antimicrob. Agents Chemother. February 2000 44: 368-377; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of the PDR Gene Network in Yeast Susceptibility to the Antifungal Antibiotic Mucidin Dana Michalkova-Papajova, Margita Obernauerova, and Julius Subik Antimicrob. Agents Chemother. February 2000 44: 418-420; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein Wen Liu and Ben Shen Antimicrob. Agents Chemother. February 2000 44: 382-392; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater Sirke Torkkell, Tero Kunnari, Kaisa Palmu, Juha Hakala, Pekka Mäntsälä, and Kristiina Ylihonko Antimicrob. Agents Chemother. February 2000 44: 396-399; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages Pascal Clayette, Marc Martin, Vincent Beringue, Nathalie Dereuddre-Bosquet, Karim T. Adjou, Michel Seman, and Dominique Dormont Antimicrob. Agents Chemother. February 2000 44: 405-407; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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May the Drug Transporter P Glycoprotein Affect the Antiviral Activity of Human Immunodeficiency Virus Type 1 Proteinase Inhibitors? Ombretta Turriziani, Paola Di Marco, Guido Antonelli, Ferdinando Dianzani;, and Ranga V. Srinivas Antimicrob. Agents Chemother. February 2000 44: 473-474; [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Acetate-Mediated Growth Inhibition in Sterol 14-Demethylation-Deficient Cells of Candida albicans Osamu Shimokawa and Hiroaki Nakayama Antimicrob. Agents Chemother. February 2000 44: 475 [Full Text] [PDF] [Reprints and Permissions]

Novel Streptomycin and Spectinomycin Resistance Gene as a Gene Cassette within a Class 1 Integron Isolated from Escherichia coli Dorthe Sandvang Antimicrob. Agents Chemother. February 2000 44: 475 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.