Contents: March 2000, Volume 44, Issue 3        Pharmacology        Susceptibility        Antiviral Agents        Biologic Response Modifiers        Mechanisms of Action        Mechanisms of Resistance        Experimental Therapeutics        Clinical Therapeutics        Chemistry; Biosynthesis        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Pharmacology:

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Carrier-Mediated Delivery of 9-(2-Phosphonylmethoxyethyl)Adenine to Parenchymal Liver Cells: a Novel Therapeutic Approach for Hepatitis B Remco L. A. de Vrueh, Erik T. Rump, Erika van de Bilt, Richard van Veghel, Jan Balzarini, Erik A. L. Biessen, Theo J. C. van Berkel, and Martin K. Bijsterbosch Antimicrob. Agents Chemother. March 2000 44: 477-483; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Sensitive Amphotericin B Immunoassay for Pharmacokinetic and Distribution Studies Sophie Machard, Frederic Theodoro, Henri Benech, Jean-Marc Grognet, and Eric Ezan Antimicrob. Agents Chemother. March 2000 44: 546-550; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Faropenem Transport across the Renal Epithelial Luminal Membrane via Inorganic Phosphate Transporter Npt1 Hiroshi Uchino, Ikumi Tamai, Hikaru Yabuuchi, Kayoko China, Ken-ichi Miyamoto, Eiji Takeda, and Akira Tsuji Antimicrob. Agents Chemother. March 2000 44: 574-577; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Safety of Ascending Single Doses of DZ-2640, a New Oral Carbapenem Antibiotic, Administered to Healthy Japanese Subjects Makoto Tanaka, Kinuyo Kato, Hideo Hakusui, Yoichi Murakami, Kenichi Sato, Yasushi Ito, and Keiji Kawamoto Antimicrob. Agents Chemother. March 2000 44: 578-582; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Apoptosis in Renal Proximal Tubules of Rats Treated with Low Doses of Aminoglycosides Mohammed El Mouedden, Guy Laurent, Marie-Paule Mingeot-Leclercq, Henryk S. Taper, Jean Cumps, and Paul M. Tulkens Antimicrob. Agents Chemother. March 2000 44: 665-675; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Pharmacodynamics of Lumefantrine (Benflumetol) in Acute Falciparum Malaria F. Ezzet, M. van Vugt, F. Nosten, S. Looareesuwan, and N. J. White Antimicrob. Agents Chemother. March 2000 44: 697-704; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys Amin A. Nomeir, Pramila Kumari, Mary Jane Hilbert, Samir Gupta, David Loebenberg, Anthony Cacciapuoti, Roberta Hare, George H. Miller, Chin-Chung Lin, and Mitchell N. Cayen Antimicrob. Agents Chemother. March 2000 44: 727-731; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Nasal Carriage in Vietnamese Children of Streptococcus pneumoniae Resistant to Multiple Antimicrobial Agents Christopher M. Parry, To Song Diep, John Wain, Nguyen Thi Tuyet Hoa, Mary Gainsborough, Diem Nga, Catrin Davies, Nguyen Hoan Phu, Tran Tinh Hien, Nicholas J. White, and Jeremy J. Farrar Antimicrob. Agents Chemother. March 2000 44: 484-488; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Novel trans-3,5-Disubstituted Pyrrolidinylthio-1-Methylcarbapenems with Potent Activities against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Rie Nagano, Kaneyoshi Shibata, Yuka Adachi, Hideaki Imamura, Terutaka Hashizume, and Hajime Morishima Antimicrob. Agents Chemother. March 2000 44: 489-495; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities and Postantibiotic Effects of Gemifloxacin Compared to Those of 11 Other Agents against Haemophilus influenzae and Moraxella catarrhalis Todd A. Davies, Linda M. Kelly, Dianne B. Hoellman, Lois M. Ednie, Catherine L. Clark, Saralee Bajaksouzian, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. March 2000 44: 633-639; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Antifungal Activities of Bafilomycin A1, Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans Maurizio Del Poeta, M. Cristina Cruz, Maria E. Cardenas, John R. Perfect, and Joseph Heitman Antimicrob. Agents Chemother. March 2000 44: 739-746; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bloodstream Infections Due to Candida Species: SENTRY Antimicrobial Surveillance Program in North America and Latin America, 1997-1998 M. A. Pfaller, R. N. Jones, G. V. Doern, H. S. Sader, S. A. Messer, A. Houston, S. Coffman, R. J. Hollis, and The SENTRY Participant Group Antimicrob. Agents Chemother. March 2000 44: 747-751; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Activities of Ciprofloxacin, Gemifloxacin, Grepafloxacin, Moxifloxacin, Ofloxacin, Sparfloxacin, Trovafloxacin, and Other Antimicrobial Agents against Bloodstream Isolates of Gram-Positive Cocci Dwight Hardy, Daniel Amsterdam, Lionel A. Mandell, and Coleman Rotstein Antimicrob. Agents Chemother. March 2000 44: 802-805; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Differential Effects of Antiretroviral Nucleoside Analogs on Mitochondrial Function in HepG2 Cells Xin-Ru Pan-Zhou, Lixin Cui, Xiao-Jian Zhou, Jean-Pierre Sommadossi, and Victor M. Darley-Usmar Antimicrob. Agents Chemother. March 2000 44: 496-503; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antihepadnaviral Activities of Combinations of Penciclovir, Lamivudine, and Adefovir Danni Colledge, Gilda Civitico, Stephen Locarnini, and Tim Shaw Antimicrob. Agents Chemother. March 2000 44: 551-560; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutational Pattern Confers Phenotypic Lamivudine Resistance in the Absence of Mutation 184V Kurt Hertogs, Stuart Bloor, Veronique De Vroey, Christel van den Eynde, Pascale Dehertogh, Anja van Cauwenberge, Martin Stürmer, Timothy Alcorn, Scott Wegner, Margriet van Houtte, Veronica Miller, and Brendan A. Larder Antimicrob. Agents Chemother. March 2000 44: 568-573; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Dose Ranging Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B Etienne M. Sokal, Eve A. Roberts, Giorgina Mieli-Vergani, Penny McPhillips, Mark Johnson, Judy Barber, Nigel Dallow, Elizabeth Boxall, and Deirdre Kelly Antimicrob. Agents Chemother. March 2000 44: 590-597; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Standardized Plaque Reduction Assay for Determination of Drug Susceptibilities of Cytomegalovirus Clinical Isolates Marie L. Landry, Sylvia Stanat, Karen Biron, Donald Brambilla, William Britt, Janet Jokela, Sunwen Chou, W. Lawrence Drew, Alejo Erice, Bruce Gilliam, Nell Lurain, Jody Manischewitz, Richard Miner, Mostafa Nokta, Patricia Reichelderfer, Stephen Spector, Adriana Weinberg, Belinda Yen-Lieberman, Clyde Crumpacker, and the AIDS Clinical Trials Group CMV Resistance Working Group Antimicrob. Agents Chemother. March 2000 44: 688-692; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Indinavir Pharmacokinetics and Parmacodynamics in Children with Human Immunodeficiency Virus Infection Giorgio Gatti, Alessandra Vigano', Natascia Sala, Stefano Vella, Matteo Bassetti, Dante Bassetti, and Nicola Principi Antimicrob. Agents Chemother. March 2000 44: 752-755; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intravitreal, Retinal, and Central Nervous System Foscarnet Concentrations after Rapid Intravenous Administration to Rabbits Luis F. López-Cortés, R. Ruiz-Valderas, M. J. Lucero-Muñoz, E. Cordero, M. T. Pastor-Ramos, and J. Marquez Antimicrob. Agents Chemother. March 2000 44: 756-759; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Activity of 2'-Deoxy-3'-Oxa-4'-Thiocytidine (BCH-10652) against Lamivudine-Resistant Human Immunodeficiency Virus Type 1 in SCID-hu Thy/Liv Mice Cheryl A. Stoddart, Mary E. Moreno, Valerie D. Linquist-Stepps, Christopher Bare, Mark R. Bogan, Alberto Gobbi, Robert W. Buckheit, Jr., Jean Bedard, Robert F. Rando, and Joseph M. McCune Antimicrob. Agents Chemother. March 2000 44: 783-786; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Delavirdine Susceptibilities and Associated Reverse Transcriptase Mutations in Human Immunodeficiency Virus Type 1 Isolates from Patients in a Phase I/II Trial of Delavirdine Monotherapy (ACTG 260) L. M. Demeter, R. W. Shafer, P. M. Meehan, J. Holden-Wiltse, M. A. Fischl, W. W. Freimuth, M. F. Para, and R. C. Reichman Antimicrob. Agents Chemother. March 2000 44: 794-797; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Consequences of Interaction of a Lipophilic Endotoxin Antagonist with Plasma Lipoproteins Jeffrey R. Rose, Maureen A. Mullarkey, William J. Christ, Lynn D. Hawkins, Melvyn Lynn, Yoshito Kishi, Kishor M. Wasan, Kathy Peteherych, and Daniel P. Rossignol Antimicrob. Agents Chemother. March 2000 44: 504-510; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Proinflammatory Cytokines on the Interplay between Roxithromycin, HMR 3647, or HMR 3004 and Human Polymorphonuclear Neutrophils D. Vazifeh, A. Bryskier, and M. T. Labro Antimicrob. Agents Chemother. March 2000 44: 511-521; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Mechanism of Uptake of a Cationic Water-Soluble Pyridinium Zinc Phthalocyanine across the Outer Membrane of Escherichia coli Andrew Minnock, David I. Vernon, Jack Schofield, John Griffiths, J. Howard Parish, and Stanley B. Brown Antimicrob. Agents Chemother. March 2000 44: 522-527; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial and Antimembrane Activities of Cecropin A in Escherichia coli Loraine Silvestro, Jeffrey N. Weiser, and Paul H. Axelsen Antimicrob. Agents Chemother. March 2000 44: 602-607; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Inositol Phosphorylceramide Synthase by Aureobasidin A in Candida and Aspergillus Species Wenyan Zhong, Matthew W. Jeffries, and Nafsika H. Georgopapadakou Antimicrob. Agents Chemother. March 2000 44: 651-653; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Flow Cytometric Monitoring of Antibiotic-Induced Injury in Escherichia coli Using Cell-Impermeant Fluorescent Probes Fiona C. Mortimer, David J. Mason, and Vanya A. Gant Antimicrob. Agents Chemother. March 2000 44: 676-681; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Flow Cytometric Investigation of Filamentation, Membrane Patency, and Membrane Potential in Escherichia coli following Ciprofloxacin Exposure H. J. Wickens, R. J. Pinney, D. J. Mason, and V. A. Gant Antimicrob. Agents Chemother. March 2000 44: 682-687; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Atovaquone and Diospyrin-Based Drugs on the Cellular ATP of Pneumocystis carinii f. sp. carinii Melanie T. Cushion, Margaret Collins, Banasri Hazra, and Edna S. Kaneshiro Antimicrob. Agents Chemother. March 2000 44: 713-719; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Capnocytophaga ochracea: Characterization of a Plasmid-Encoded Extended-Spectrum TEM-17 -Lactamase in the Phylum Flavobacter-Bacteroides Agnes Rosenau, Blandine Cattier, Nathalie Gousset, Patrick Harriau, Alain Philippon, and Roland Quentin Antimicrob. Agents Chemother. March 2000 44: 760-762; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitans to These Antibiotics Daniel Grenier, Marie-Pierre Huot, and Denis Mayrand Antimicrob. Agents Chemother. March 2000 44: 763-766; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effects and Bactericidal Activities of Clarithromycin-14-Hydroxy-Clarithromycin, versus Those of Amoxicillin-Clavulanate, against Anaerobes Rose Jung, Chad R. Messick, Susan L. Pendland, Eljim P. Tesoro, Karen J. Losendahl, Christopher A. Schriever, and Larry H. Danziger Antimicrob. Agents Chemother. March 2000 44: 778-779; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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pncA Mutations as a Major Mechanism of Pyrazinamide Resistance in Mycobacterium tuberculosis: Spread of a Monoresistant Strain in Quebec, Canada Shao-Ji Cheng, Louise Thibert, Tracy Sanchez, Leonid Heifets, and Ying Zhang Antimicrob. Agents Chemother. March 2000 44: 528-532; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

ampR Gene Mutations That Greatly Increase Class C -Lactamase Activity in Enterobacter cloacae Akio Kuga, Ryoichi Okamoto, and Matsuhisa Inoue Antimicrob. Agents Chemother. March 2000 44: 561-567; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inactivation of the ampD Gene in Pseudomonas aeruginosa Leads to Moderate-Basal-Level and Hyperinducible AmpC -Lactamase Expression Taimour Yousef Langaee, Luc Gagnon, and Ann Huletsky Antimicrob. Agents Chemother. March 2000 44: 583-589; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Frequent Association between Alteration of the rdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori Jacques Tankovic, Dominique Lamarque, Jean-Charles Delchier, Claude-James Soussy, Agnes Labigne, and Peter J. Jenks Antimicrob. Agents Chemother. March 2000 44: 608-613; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Sequence Analyses of GES-1, a Novel Class A Extended-Spectrum -Lactamase, and the Class 1 Integron In52 from Klebsiella pneumoniae Laurent Poirel, Isabelle Le Thomas, Thierry Naas, Amal Karim, and Patrice Nordmann Antimicrob. Agents Chemother. March 2000 44: 622-632; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms Alexei Brooun, Songhua Liu, and Kim Lewis Antimicrob. Agents Chemother. March 2000 44: 640-646; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the fomA and fomB Gene Products from Streptomyces wedmorensis, Which Confer Fosfomycin Resistance on Escherichia coli Seiji Kobayashi, Tomohisa Kuzuyama, and Haruo Seto Antimicrob. Agents Chemother. March 2000 44: 647-650; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assignment of the Substrate-Selective Subunits of the MexEF-OprN Multidrug Efflux Pump of Pseudomonas aeruginosa Hideaki Maseda, Hiroshi Yoneyama, and Taiji Nakae Antimicrob. Agents Chemother. March 2000 44: 658-664; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Biopesticide Paenibacillus popilliae Has a Vancomycin Resistance Gene Cluster Homologous to the Enterococcal VanA Vancomycin Resistance Gene Cluster Robin Patel, Kerryl Piper, Franklin R. Cockerill, III, James M. Steckelberg, and Allan A. Yousten Antimicrob. Agents Chemother. March 2000 44: 705-709; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Mechanisms of Fluoroquinolone Resistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Shah Jalal, Oana Ciofu, Niels Høiby, Naomasa Gotoh, and Bengt Wretlind Antimicrob. Agents Chemother. March 2000 44: 710-712; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action Peter V. Adrian, Wenjun Zhao, Todd A. Black, Karen J. Shaw, Roberta S. Hare, and Keith P. Klugman Antimicrob. Agents Chemother. March 2000 44: 732-738; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Occurrence of the New Tetracycline Resistance Gene tet(W) in Bacteria from the Human Gut Karen P. Scott, Claire M. Melville, Teresa M. Barbosa, and Harry J. Flint Antimicrob. Agents Chemother. March 2000 44: 775-777; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Streptococcus gordonii Strains Resistant to Fluorodeoxyuridine Contain Mutations in the Thymidine Kinase Gene and Are Deficient in Thymidine Kinase Activity C. A. Franke, T. M. Bolman, S. A. Ottum, K. F. Jones, and D. E. Hruby Antimicrob. Agents Chemother. March 2000 44: 787-789; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the Tn916-like Transposon Tn3872 in a Strain of Abiotrophia defectiva (Streptococcus defectivus) Causing Sequential Episodes of Endocarditis in a Child Claire Poyart, Gilles Quesne, Philippe Acar, Patrick Berche, and Patrick Trieu-Cuot Antimicrob. Agents Chemother. March 2000 44: 790-793; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Convenient Assay for Estimating the Possible Involvement of Efflux of Fluoroquinolones by Streptococcus pneumoniae and Staphylococcus aureus: Evidence for Diminished Moxifloxacin, Sparfloxacin, and Trovafloxacin Efflux Rebecca Beyer, Ekaterina Pestova, John J. Millichap, Valentina Stosor, Gary A. Noskin, and Lance R. Peterson Antimicrob. Agents Chemother. March 2000 44: 798-801; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Antibacterial Efficacy of Gentamicin Encapsulated in pH-Sensitive Liposomes against an In Vivo Salmonella enterica Serovar Typhimurium Intracellular Infection Model Carol Cordeiro, David J. Wiseman, Peter Lutwyche, Mitchell Uh, Jennifer C. Evans, B. Brett Finlay, and Murray S. Webb Antimicrob. Agents Chemother. March 2000 44: 533-539; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Liposomal Amphotericin B with Prolonged Circulation in Blood in Treatment of Severe Pulmonary Aspergillosis in Leukopenic Rats Els W. M. Van Etten, Lorna E. T. Stearne-Cullen, Marian T. Ten Kate, and Irma A. J. M. Bakker-Woudenberg Antimicrob. Agents Chemother. March 2000 44: 540-545; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Trovafloxacin, Gatifloxacin, Clinafloxacin, Sparfloxacin, Levofloxacin, and Ciprofloxacin against Penicillin-Resistant Streptococcus pneumoniae in an In Vitro Infection Model Ellie Hershberger and Michael J. Rybak Antimicrob. Agents Chemother. March 2000 44: 598-601; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of FK463, a New Lipopeptide Antifungal Agent, in Mouse Models of Disseminated Candidiasis and Aspergillosis Fumiaki Ikeda, Yoshimi Wakai, Satoru Matsumoto, Katsuyuki Maki, Etsuko Watabe, Shuichi Tawara, Toshio Goto, Yuji Watanabe, Fumio Matsumoto, and Shogo Kuwahara Antimicrob. Agents Chemother. March 2000 44: 614-618; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of FK463, a New Lipopeptide Antifungal Agent, in Mouse Models of Pulmonary Aspergillosis Satoru Matsumoto, Yoshimi Wakai, Toru Nakai, Kazuo Hatano, Tomoe Ushitani, Fumiaki Ikeda, Shuichi Tawara, Toshio Goto, Fumio Matsumoto, and Shogo Kuwahara Antimicrob. Agents Chemother. March 2000 44: 619-621; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Linezolid in Experimental Otitis Media S. I. Pelton, M. Figueira, R. Albut, and D. Stalker Antimicrob. Agents Chemother. March 2000 44: 654-657; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gemifloxacin Is Effective in Experimental Pneumococcal Meningitis A. Smirnov, A. Wellmer, J. Gerber, K. Maier, S. Henne, and R. Nau Antimicrob. Agents Chemother. March 2000 44: 767-770; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pulsed Ultrasound Enhances the Killing of Escherichia coli Biofilms by Aminoglycoside Antibiotics In Vivo Andrea M. Rediske, Beverly L. Roeder, Jared L. Nelson, Rachel L. Robison, G. Bruce Schaalje, Richard A. Robison, and William G. Pitt Antimicrob. Agents Chemother. March 2000 44: 771-772; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Activities of Ciprofloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Dynamic Model Stephen H. Zinner, Kelly Simmons, and Deborah Gilbert Antimicrob. Agents Chemother. March 2000 44: 773-774; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of SCH56592 in a Rabbit Model of Invasive Aspergillosis William R. Kirkpatrick, Robert K. McAtee, Annette W. Fothergill, David Loebenberg, Michael G. Rinaldi, and Thomas F. Patterson Antimicrob. Agents Chemother. March 2000 44: 780-782; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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A Double-Blind Placebo-Controlled Study of an Infusion of Lexipafant (Platelet-Activating Factor Receptor Antagonist) in Patients with Severe Sepsis Yupin Suputtamongkol, Sunanta Intaranongpai, Michael D. Smith, Brian Angus, Wipada Chaowagul, Chairat Permpikul, Julie A. Simpson, Amorn Leelarasamee, Lloyd Curtis, and Nicholas J. White Antimicrob. Agents Chemother. March 2000 44: 693-696; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Enzymes Catalyzing the Early Steps of Clavulanic Acid Biosynthesis Are Encoded by Two Sets of Paralogous Genes in Streptomyces clavuligerus Susan E. Jensen, Kenneth J. Elder, Kwamena A. Aidoo, and Ashish S. Paradkar Antimicrob. Agents Chemother. March 2000 44: 720-726; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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A Point Mutation Associated with Bacterial Macrolide Resistance Is Present in Both 23S rRNA Genes of an Erythromycin-Resistant Treponema pallidum Clinical Isolate L. V. Stamm and H. L. Bergen Antimicrob. Agents Chemother. March 2000 44: 806-807; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.