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Pharmacology:

P. M. Beringer, A. A. T. M. M. Vinks, R. W. Jelliffe, and B. J. Shapiro

Pharmacokinetics of Tobramycin in Adults with Cystic Fibrosis: Implications for Once-Daily Administration
Antimicrob. Agents Chemother. 2000 44: 809-813. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laurence Veronese, Jacques Rautaureau, Brian M. Sadler, Catherine Gillotin, Jean-Pierre Petite, Bernard Pillegand, Michel Delvaux, Claude Masliah, Sandrine Fosse, Yu Lou, and Daniel S. Stein

Single-Dose Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor, in Subjects with Normal or Impaired Hepatic Function
Antimicrob. Agents Chemother. 2000 44: 821-826. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marie-Agnes Simonin, Pascale Gegout-Pottie, Alain Minn, Pierre Gillet, Patrick Netter, and Bernard Terlain

Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to Collagen
Antimicrob. Agents Chemother. 2000 44: 867-872. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sergey N. Vostrov, Olga V. Kononenko, Irene Y. Lubenko, Stephen H. Zinner, and Alexander A. Firsov

Comparative Pharmacodynamics of Gatifloxacin and Ciprofloxacin in an In Vitro Dynamic Model: Prediction of Equiefficient Doses and the Breakpoints of the Area under the Curve/MIC Ratio
Antimicrob. Agents Chemother. 2000 44: 879-884. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Iciar Echevarría, Celia Barturen, María Jesús Renedo, Iñaki F. Trocóniz, and M. Carmen Dios-Viéitez

Comparative Pharmacokinetics, Tissue Distributions, and Effects on Renal Function of Novel Polymeric Formulations of Amphotericin B and Amphotericin B-Deoxycholate in Rats
Antimicrob. Agents Chemother. 2000 44: 898-904. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jehangir K. Khan, Hashem Montaseri, Marzena Poglod, Hai-Zhi Bu, Zhong Zuo, Sameeh M. Salama, Mohsen Daneshtalab, and Ronald G. Micetich

Interspecies Comparison of Pharmacokinetics of the Novel Triazole Antifungal Agent SYN-2869 and Its Derivatives
Antimicrob. Agents Chemother. 2000 44: 910-915. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

C. Lin, S. Gupta, D. Loebenberg, and M. N. Cayen

Pharmacokinetics of an Everninomicin (SCH 27899) in Mice, Rats, Rabbits, and Cynomolgus Monkeys following Intravenous Administration
Antimicrob. Agents Chemother. 2000 44: 916-919. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

D. Andes and M. van Ogtrop

In Vivo Characterization of the Pharmacodynamics of Flucytosine in a Neutropenic Murine Disseminated Candidiasis Model
Antimicrob. Agents Chemother. 2000 44: 938-942. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. L. van Ogtrop, D. Andes, T. J. Stamstad, B. Conklin, W. J. Weiss, W. A. Craig, and O. Vesga

In Vivo Pharmacodynamic Activities of Two Glycylcyclines (GAR-936 and WAY 152,288) against Various Gram-Positive and Gram-Negative Bacteria
Antimicrob. Agents Chemother. 2000 44: 943-949. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Andreas H. Groll, Diana Mickiene, Kathy Werner, Ruta Petraitiene, Vidmantas Petraitis, Myrna Calendario, Aida Field-Ridley, Jeremy Crisp, Stephen C. Piscitelli, and Thomas J. Walsh

Compartmental Pharmacokinetics and Tissue Distribution of Multilamellar Liposomal Nystatin in Rabbits
Antimicrob. Agents Chemother. 2000 44: 950-957. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paul Newton, Yupin Suputtamongkol, Paktiya Teja-Isavadharm, Sasithon Pukrittayakamee, V Navaratnam, Imelda Bates, and Nicholas White

Antimalarial Bioavailability and Disposition of Artesunate in Acute Falciparum Malaria
Antimicrob. Agents Chemother. 2000 44: 972-977. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Donald F. Brophy, Debra S. Israel, Antonio Pastor, Catherine Gillotin, Greg E. Chittick, William T. Symonds, Yu Lou, Brian M. Sadler, and Ron E. Polk

Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers
Antimicrob. Agents Chemother. 2000 44: 978-984. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John E. Conte, Jr., Jeffrey A. Golden, Mari McQuitty, Juliana Kipps, Emil T. Lin, and Elisabeth Zurlinden

Single-Dose Intrapulmonary Pharmacokinetics of Rifapentine in Normal Subjects
Antimicrob. Agents Chemother. 2000 44: 985-990. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Courtney V. Fletcher, Richard C. Brundage, Rory P. Remmel, Linda M. Page, Dennis Weller, Nancy R. Calles, Cara Simon, and Mark W. Kline

Pharmacologic Characteristics of Indinavir, Didanosine, and Stavudine in Human Immunodeficiency Virus-Infected Children Receiving Combination Therapy
Antimicrob. Agents Chemother. 2000 44: 1029-1034. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Katherine E. Warren, Cynthia M. McCully, Thomas J. Walsh, and Frank M. Balis

Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates
Antimicrob. Agents Chemother. 2000 44: 1100-1101. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

W. V. Kern, M. Oethinger, A. S. Jellen-Ritter, and S. B. Levy

Non-Target Gene Mutations in the Development of Fluoroquinolone Resistance in Escherichia coli
Antimicrob. Agents Chemother. 2000 44: 814-820. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

María José Ferrándiz, Asunción Fenoll, Josefina Liñares, and Adela G. De La Campa

Horizontal Transfer of parC and gyrA in Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2000 44: 840-847. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laurent Poirel, Thierry Naas, Delphine Nicolas, Louis Collet, Samuel Bellais, Jean-Didier Cavallo, and Patrice Nordmann

Characterization of VIM-2, a Carbapenem-Hydrolyzing Metallo--Lactamase and Its Plasmid- and Integron-Borne Gene from a Pseudomonas aeruginosa Clinical Isolate in France
Antimicrob. Agents Chemother. 2000 44: 891-897. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Asunción Seoane and Juan M. García Lobo

Identification of a Streptogramin A Acetyltransferase Gene in the Chromosome of Yersinia enterocolitica
Antimicrob. Agents Chemother. 2000 44: 905-909. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Aránzazu Portillo, Fernanda Ruiz-Larrea, Myriam Zarazaga, Ana Alonso, Jose Luis Martinez, and Carmen Torres

Macrolide Resistance Genes in Enterococcus spp.
Antimicrob. Agents Chemother. 2000 44: 967-971. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. M. Nzila, E. K. Mberu, J. Sulo, H. Dayo, P. A. Winstanley, C. H. Sibley, and W. M. Watkins

Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum: Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan Parasites
Antimicrob. Agents Chemother. 2000 44: 991-996. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

J. Silva, C. Aguilar, G. Ayala, M. A. Estrada, U. Garza-Ramos, R. Lara-Lemus, and L. Ledezma

TLA-1: a New Plasmid-Mediated Extended-Spectrum -Lactamase from Escherichia coli
Antimicrob. Agents Chemother. 2000 44: 997-1003. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Keith S. Kaye, Anthony D. Harris, Howard Gold, and Yehuda Carmeli

Risk Factors for Recovery of Ampicillin-Sulbactam-Resistant Escherichia coli in Hospitalized Patients
Antimicrob. Agents Chemother. 2000 44: 1004-1009. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Daniele Choury, Marie-France Szajnert, Marie-Laure Joly-Guillou, Kemal Azibi, Marc Delpech, and Gérard Paul

Nucleotide Sequence of the bla_RTG-2 (CARB-5) Gene and Phylogeny of a New Group of Carbenicillinases
Antimicrob. Agents Chemother. 2000 44: 1070-1074. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Markus Heep, Ulrich Rieger, Daniela Beck, and Norbert Lehn

Mutations in the Beginning of the rpoB Gene Can Induce Resistance to Rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 2000 44: 1075-1077. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tsuneko Ono, Sumiko Shiota, Katsuhiko Hirota, Ken Nemoto, Tomofusa Tsuchiya, and Yoichiro Miyake

Susceptibilities of Oral and Nasal Isolates of Streptococcus mitis and Streptococcus oralis to Macrolides and PCR Detection of Resistance Genes
Antimicrob. Agents Chemother. 2000 44: 1078-1080. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Meifang Yuan, Lucinda M. C. Hall, Paul H. M. Savelkoul, Christina M. J. E. Vandenbroucke-Grauls, and David M. Livermore

SHV-13, a Novel Extended-Spectrum -Lactamase, in Klebsiella pneumoniae Isolates from Patients in an Intensive Care Unit in Amsterdam
Antimicrob. Agents Chemother. 2000 44: 1081-1084. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

David J. Novo, Nancy G. Perlmutter, Richard H. Hunt, and Howard M. Shapiro

Multiparameter Flow Cytometric Analysis of Antibiotic Effects on Membrane Potential, Membrane Permeability, and Bacterial Counts of Staphylococcus aureus and Micrococcus luteus
Antimicrob. Agents Chemother. 2000 44: 827-834. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Karl E. Miletti and Michael J. Leibowitz

Pentamidine Inhibition of Group I Intron Splicing in Candida albicans Correlates with Growth Inhibition
Antimicrob. Agents Chemother. 2000 44: 958-966. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lei Jiang, Pei-Chieh Lee, John White, and Pradipsinh K. Rathod

Potent and Selective Activity of a Combination of Thymidine and 1843U89, a Folate-Based Thymidylate Synthase Inhibitor, against Plasmodium falciparum
Antimicrob. Agents Chemother. 2000 44: 1047-1050. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Esther Pfeil and Bernd Wiedemann

Pronounced Postantibiotic Effect of Quinupristin-Dalfopristin in Static Cultures of Staphylococcus aureus: an Effect Not Seen with Other Antibiotics
Antimicrob. Agents Chemother. 2000 44: 1059-1061. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Erika J. Ernst, Michael E. Klepser, and Michael A. Pfaller

Postantifungal Effects of Echinocandin, Azole, and Polyene Antifungal Agents against Candida albicans and Cryptococcus neoformans
Antimicrob. Agents Chemother. 2000 44: 1108-1111. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

Frank P. Mockenhaupt, Jürgen May, Yngve Bergqvist, Olusegun G. Ademowo, Peter E. Olumese, Adeyinka G. Falusi, Lars Großterlinden, Christian G. Meyer, and Ulrich Bienzle

Concentrations of Chloroquine and Malaria Parasites in Blood in Nigerian Children
Antimicrob. Agents Chemother. 2000 44: 835-839. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

C. M. Kunin and W. Y. Ellis

Antimicrobial Activities of Mefloquine and a Series of Related Compounds
Antimicrob. Agents Chemother. 2000 44: 848-852. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Victoria Hertle Brophy, John Vasquez, Richard G. Nelson, John R. Forney, Andre Rosowsky, and Carol Hopkins Sibley

Identification of Cryptosporidium parvum Dihydrofolate Reductase Inhibitors by Complementation in Saccharomyces cerevisiae
Antimicrob. Agents Chemother. 2000 44: 1019-1028. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Maria D. Appleman, Howard Belzberg, Diane M. Citron, Peter N. R. Heseltine, Albert E. Yellin, James Murray, and Thomas V. Berne

In Vitro Activities of Nontraditional Antimicrobials against Multiresistant Acinetobacter baumannii Strains Isolated in an Intensive Care Unit Outbreak
Antimicrob. Agents Chemother. 2000 44: 1035-1040. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael J. Rybak, Ellie Hershberger, Tabitha Moldovan, and Richard G. Grucz

In Vitro Activities of Daptomycin, Vancomycin, Linezolid, and Quinupristin-Dalfopristin against Staphylococci and Enterococci, Including Vancomycin- Intermediate and -Resistant Strains
Antimicrob. Agents Chemother. 2000 44: 1062-1066. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Dianne B. Hoellman, Glenn A. Pankuch, Michael R. Jacobs, and Peter C. Appelbaum

Antipneumococcal Activities of GAR-936 (a New Glycylcycline) Compared to Those of Nine Other Agents against Penicillin-Susceptible and -Resistant Pneumococci
Antimicrob. Agents Chemother. 2000 44: 1085-1088. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

George G. Zhanel, James A. Karlowsky, Godfrey K. M. Harding, Anita Carrie, Tony Mazzulli, Donald E. Low, The Canadian Urinary Isolate Study Group, and Daryl J. Hoban

A Canadian National Surveillance Study of Urinary Tract Isolates from Outpatients: Comparison of the Activities of Trimethoprim-Sulfamethoxazole, Ampicillin, Mecillinam, Nitrofurantoin, and Ciprofloxacin
Antimicrob. Agents Chemother. 2000 44: 1089-1092. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Dana Milatovic, Franz-Josef Schmitz, Sylvain Brisse, Jan Verhoef, and Ad C. Fluit

In Vitro Activities of Sitafloxacin (DU-6859a) and Six Other Fluoroquinolones against 8,796 Clinical Bacterial Isolates
Antimicrob. Agents Chemother. 2000 44: 1102-1107. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sebastian Strigl, Patricia M. Roblin, Tamara Reznik, and Margaret R. Hammerschlag

In Vitro Activity of ABT 773, a New Ketolide Antibiotic, against Chlamydia pneumoniae
Antimicrob. Agents Chemother. 2000 44: 1112-1113. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Laurent Placidi, Erika Cretton-Scott, Gilles Gosselin, Claire Pierra, Raymond F. Schinazi, Jean-Louis Imbach, Mahmoud H. el Kouni, and Jean-Pierre Sommadossi

Intracellular Metabolism of -L-2',3'-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity
Antimicrob. Agents Chemother. 2000 44: 853-858. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

W. Markland, T. J. McQuaid, J. Jain, and A. D. Kwong

Broad-Spectrum Antiviral Activity of the IMP Dehydrogenase Inhibitor VX-497: a Comparison with Ribavirin and Demonstration of Antiviral Additivity with Alpha Interferon
Antimicrob. Agents Chemother. 2000 44: 859-866. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Roland Sahli, Graciela Andrei, Christine Estrade, Robert Snoeck, and Pascal R. A. Meylan

A Rapid Phenotypic Assay for Detection of Acyclovir-Resistant Varicella-Zoster Virus with Mutations in the Thymidine Kinase Open Reading Frame
Antimicrob. Agents Chemother. 2000 44: 873-878. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christos J. Petropoulos, Neil T. Parkin, Kay L. Limoli, Yolanda S. Lie, Terri Wrin, Wei Huang, Huan Tian, Douglas Smith, Genine A. Winslow, Daniel J. Capon, and Jeannette M. Whitcomb

A Novel Phenotypic Drug Susceptibility Assay for Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2000 44: 920-928. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jean Bedard, Suzanne May, Lucille L'Heureux, Thomas Stamminger, Alice Copsey, John Drach, John Huffman, Laval Chan, Haolun Jin, and Robert F. Rando

Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus
Antimicrob. Agents Chemother. 2000 44: 929-937. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Walter T. Hughes, Jerry L. Shenep, John H. Rodman, Arnold Fridland, Rodney Willoughby, Suzette Blanchard, Lynette Purdue, Dion F. Coakley, Kenneth C. Cundy, Mary Culnane, Bonnie Zimmer, Sandra Burchett, Jennifer S. Read, and The Pediatric AIDS Clinical Trials Group

Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2000 44: 1041-1046. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Stuart Snyder, D. Z. D'Argenio, Owen Weislow, John A. Bilello, and G. L. Drusano

The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic
Antimicrob. Agents Chemother. 2000 44: 1051-1058. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Drew Endy and John Yin

Toward Antiviral Strategies That Resist Viral Escape
Antimicrob. Agents Chemother. 2000 44: 1097-1099. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Olivier Mimoz, Sophie Leotard, Anne Jacolot, Christophe Padoin, Kamel Louchahi, Olivier Petitjean, and Patrice Nordmann

Efficacies of Imipenem, Meropenem, Cefepime, and Ceftazidime in Rats with Experimental Pneumonia Due to a Carbapenem-Hydrolyzing -Lactamase-Producing Strain of Enterobacter cloacae
Antimicrob. Agents Chemother. 2000 44: 885-890. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Erjian Wang, Marie Simard, Yves Bergeron, Denis Beauchamp, and Michel G. Bergeron

In Vivo Activity and Pharmacokinetics of Ziracin (SCH27899), a New Long-Acting Everninomicin Antibiotic, in a Murine Model of Penicillin-Susceptible or Penicillin-Resistant Pneumococcal Pneumonia
Antimicrob. Agents Chemother. 2000 44: 1010-1018. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Teresa Krakauer

Coordinate Suppression of Superantigen-Induced Cytokine Production and T-Cell Proliferation by a Small Nonpeptidic Inhibitor of Class II Major Histocompatibility Complex and CD4 Interaction
Antimicrob. Agents Chemother. 2000 44: 1067-1069. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marie-Laure Veyries, Francois Faurisson, Marie-Laure Joly-Guillou, and Bernard Rouveix

Control of Staphylococcal Adhesion to Polymethylmethacrylate and Enhancement of Susceptibility to Antibiotics by Poloxamer 407
Antimicrob. Agents Chemother. 2000 44: 1093-1096. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Recent Approvals:

New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 1999 and New Indications for Previously Approved Agents
Antimicrob. Agents Chemother. 2000 44: 1114-1115. [Full Text] [PDF] [Reprints and Permissions]  

Letters:

T. R. Shultz, J. W. Tapsall, P. A. White, and P. J. Newton

An Invasive Isolate of Neisseria meningitidis Showing Decreased Susceptibility to Quinolones
Antimicrob. Agents Chemother. 2000 44: 1116. [Full Text] [PDF] [Reprints and Permissions]  

Keith Gallicano; and Angela D. M. Kashuba

Antiretroviral-Drug Concentrations in Semen
Antimicrob. Agents Chemother. 2000 44: 1117-1118. [Full Text] [PDF] [Reprints and Permissions]  

Author's Correction:

Angela D. M. Kashuba, John R. Dyer, Linda M. Kramer, Ralph H. Raasch, Joseph J. Eron, and Myron S. Cohen

Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2000 44: 1119. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.