Contents: April 2000, Volume 44, Issue 4        Pharmacology        Mechanisms of Resistance        Mechanisms of Action        Clinical Therapeutics        Susceptibility        Antiviral Agents        Experimental Therapeutics        Recent Approvals        Letters        Author's Correction Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Pharmacology:

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Pharmacokinetics of Tobramycin in Adults with Cystic Fibrosis: Implications for Once-Daily Administration P. M. Beringer, A. A. T. M. M. Vinks, R. W. Jelliffe, and B. J. Shapiro Antimicrob. Agents Chemother. April 2000 44: 809-813; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor, in Subjects with Normal or Impaired Hepatic Function Laurence Veronese, Jacques Rautaureau, Brian M. Sadler, Catherine Gillotin, Jean-Pierre Petite, Bernard Pillegand, Michel Delvaux, Claude Masliah, Sandrine Fosse, Yu Lou, and Daniel S. Stein Antimicrob. Agents Chemother. April 2000 44: 821-826; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to Collagen Marie-Agnes Simonin, Pascale Gegout-Pottie, Alain Minn, Pierre Gillet, Patrick Netter, and Bernard Terlain Antimicrob. Agents Chemother. April 2000 44: 867-872; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Pharmacodynamics of Gatifloxacin and Ciprofloxacin in an In Vitro Dynamic Model: Prediction of Equiefficient Doses and the Breakpoints of the Area under the Curve/MIC Ratio Sergey N. Vostrov, Olga V. Kononenko, Irene Y. Lubenko, Stephen H. Zinner, and Alexander A. Firsov Antimicrob. Agents Chemother. April 2000 44: 879-884; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Pharmacokinetics, Tissue Distributions, and Effects on Renal Function of Novel Polymeric Formulations of Amphotericin B and Amphotericin B-Deoxycholate in Rats Iciar Echevarría, Celia Barturen, María Jesús Renedo, Iñaki F. Trocóniz, and M. Carmen Dios-Viéitez Antimicrob. Agents Chemother. April 2000 44: 898-904; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interspecies Comparison of Pharmacokinetics of the Novel Triazole Antifungal Agent SYN-2869 and Its Derivatives Jehangir K. Khan, Hashem Montaseri, Marzena Poglod, Hai-Zhi Bu, Zhong Zuo, Sameeh M. Salama, Mohsen Daneshtalab, and Ronald G. Micetich Antimicrob. Agents Chemother. April 2000 44: 910-915; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of an Everninomicin (SCH 27899) in Mice, Rats, Rabbits, and Cynomolgus Monkeys following Intravenous Administration C. Lin, S. Gupta, D. Loebenberg, and M. N. Cayen Antimicrob. Agents Chemother. April 2000 44: 916-919; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Characterization of the Pharmacodynamics of Flucytosine in a Neutropenic Murine Disseminated Candidiasis Model D. Andes and M. van Ogtrop Antimicrob. Agents Chemother. April 2000 44: 938-942; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Pharmacodynamic Activities of Two Glycylcyclines (GAR-936 and WAY 152,288) against Various Gram-Positive and Gram-Negative Bacteria M. L. van Ogtrop, D. Andes, T. J. Stamstad, B. Conklin, W. J. Weiss, W. A. Craig, and O. Vesga Antimicrob. Agents Chemother. April 2000 44: 943-949; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Compartmental Pharmacokinetics and Tissue Distribution of Multilamellar Liposomal Nystatin in Rabbits Andreas H. Groll, Diana Mickiene, Kathy Werner, Ruta Petraitiene, Vidmantas Petraitis, Myrna Calendario, Aida Field-Ridley, Jeremy Crisp, Stephen C. Piscitelli, and Thomas J. Walsh Antimicrob. Agents Chemother. April 2000 44: 950-957; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimalarial Bioavailability and Disposition of Artesunate in Acute Falciparum Malaria Paul Newton, Yupin Suputtamongkol, Paktiya Teja-Isavadharm, Sasithon Pukrittayakamee, V Navaratnam, Imelda Bates, and Nicholas White Antimicrob. Agents Chemother. April 2000 44: 972-977; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers Donald F. Brophy, Debra S. Israel, Antonio Pastor, Catherine Gillotin, Greg E. Chittick, William T. Symonds, Yu Lou, Brian M. Sadler, and Ron E. Polk Antimicrob. Agents Chemother. April 2000 44: 978-984; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Intrapulmonary Pharmacokinetics of Rifapentine in Normal Subjects John E. Conte, Jr., Jeffrey A. Golden, Mari McQuitty, Juliana Kipps, Emil T. Lin, and Elisabeth Zurlinden Antimicrob. Agents Chemother. April 2000 44: 985-990; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacologic Characteristics of Indinavir, Didanosine, and Stavudine in Human Immunodeficiency Virus-Infected Children Receiving Combination Therapy Courtney V. Fletcher, Richard C. Brundage, Rory P. Remmel, Linda M. Page, Dennis Weller, Nancy R. Calles, Cara Simon, and Mark W. Kline Antimicrob. Agents Chemother. April 2000 44: 1029-1034; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates Katherine E. Warren, Cynthia M. McCully, Thomas J. Walsh, and Frank M. Balis Antimicrob. Agents Chemother. April 2000 44: 1100-1101; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Non-Target Gene Mutations in the Development of Fluoroquinolone Resistance in Escherichia coli W. V. Kern, M. Oethinger, A. S. Jellen-Ritter, and S. B. Levy Antimicrob. Agents Chemother. April 2000 44: 814-820; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Horizontal Transfer of parC and gyrA in Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae María José Ferrándiz, Asunción Fenoll, Josefina Liñares, and Adela G. De La Campa Antimicrob. Agents Chemother. April 2000 44: 840-847; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of VIM-2, a Carbapenem-Hydrolyzing Metallo--Lactamase and Its Plasmid- and Integron-Borne Gene from a Pseudomonas aeruginosa Clinical Isolate in France Laurent Poirel, Thierry Naas, Delphine Nicolas, Louis Collet, Samuel Bellais, Jean-Didier Cavallo, and Patrice Nordmann Antimicrob. Agents Chemother. April 2000 44: 891-897; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of a Streptogramin A Acetyltransferase Gene in the Chromosome of Yersinia enterocolitica Asunción Seoane and Juan M. García Lobo Antimicrob. Agents Chemother. April 2000 44: 905-909; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Macrolide Resistance Genes in Enterococcus spp. Aránzazu Portillo, Fernanda Ruiz-Larrea, Myriam Zarazaga, Ana Alonso, Jose Luis Martinez, and Carmen Torres Antimicrob. Agents Chemother. April 2000 44: 967-971; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum: Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan Parasites A. M. Nzila, E. K. Mberu, J. Sulo, H. Dayo, P. A. Winstanley, C. H. Sibley, and W. M. Watkins Antimicrob. Agents Chemother. April 2000 44: 991-996; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

TLA-1: a New Plasmid-Mediated Extended-Spectrum -Lactamase from Escherichia coli J. Silva, C. Aguilar, G. Ayala, M. A. Estrada, U. Garza-Ramos, R. Lara-Lemus, and L. Ledezma Antimicrob. Agents Chemother. April 2000 44: 997-1003; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Risk Factors for Recovery of Ampicillin-Sulbactam-Resistant Escherichia coli in Hospitalized Patients Keith S. Kaye, Anthony D. Harris, Howard Gold, and Yehuda Carmeli Antimicrob. Agents Chemother. April 2000 44: 1004-1009; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nucleotide Sequence of the blaRTG-2 (CARB-5) Gene and Phylogeny of a New Group of Carbenicillinases Daniele Choury, Marie-France Szajnert, Marie-Laure Joly-Guillou, Kemal Azibi, Marc Delpech, and Gérard Paul Antimicrob. Agents Chemother. April 2000 44: 1070-1074; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in the Beginning of the rpoB Gene Can Induce Resistance to Rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis Markus Heep, Ulrich Rieger, Daniela Beck, and Norbert Lehn Antimicrob. Agents Chemother. April 2000 44: 1075-1077; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Oral and Nasal Isolates of Streptococcus mitis and Streptococcus oralis to Macrolides and PCR Detection of Resistance Genes Tsuneko Ono, Sumiko Shiota, Katsuhiko Hirota, Ken Nemoto, Tomofusa Tsuchiya, and Yoichiro Miyake Antimicrob. Agents Chemother. April 2000 44: 1078-1080; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

SHV-13, a Novel Extended-Spectrum -Lactamase, in Klebsiella pneumoniae Isolates from Patients in an Intensive Care Unit in Amsterdam Meifang Yuan, Lucinda M. C. Hall, Paul H. M. Savelkoul, Christina M. J. E. Vandenbroucke-Grauls, and David M. Livermore Antimicrob. Agents Chemother. April 2000 44: 1081-1084; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Multiparameter Flow Cytometric Analysis of Antibiotic Effects on Membrane Potential, Membrane Permeability, and Bacterial Counts of Staphylococcus aureus and Micrococcus luteus David J. Novo, Nancy G. Perlmutter, Richard H. Hunt, and Howard M. Shapiro Antimicrob. Agents Chemother. April 2000 44: 827-834; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pentamidine Inhibition of Group I Intron Splicing in Candida albicans Correlates with Growth Inhibition Karl E. Miletti and Michael J. Leibowitz Antimicrob. Agents Chemother. April 2000 44: 958-966; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent and Selective Activity of a Combination of Thymidine and 1843U89, a Folate-Based Thymidylate Synthase Inhibitor, against Plasmodium falciparum Lei Jiang, Pei-Chieh Lee, John White, and Pradipsinh K. Rathod Antimicrob. Agents Chemother. April 2000 44: 1047-1050; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pronounced Postantibiotic Effect of Quinupristin-Dalfopristin in Static Cultures of Staphylococcus aureus: an Effect Not Seen with Other Antibiotics Esther Pfeil and Bernd Wiedemann Antimicrob. Agents Chemother. April 2000 44: 1059-1061; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantifungal Effects of Echinocandin, Azole, and Polyene Antifungal Agents against Candida albicans and Cryptococcus neoformans Erika J. Ernst, Michael E. Klepser, and Michael A. Pfaller Antimicrob. Agents Chemother. April 2000 44: 1108-1111; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Concentrations of Chloroquine and Malaria Parasites in Blood in Nigerian Children Frank P. Mockenhaupt, Jürgen May, Yngve Bergqvist, Olusegun G. Ademowo, Peter E. Olumese, Adeyinka G. Falusi, Lars Großterlinden, Christian G. Meyer, and Ulrich Bienzle Antimicrob. Agents Chemother. April 2000 44: 835-839; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Antimicrobial Activities of Mefloquine and a Series of Related Compounds C. M. Kunin and W. Y. Ellis Antimicrob. Agents Chemother. April 2000 44: 848-852; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of Cryptosporidium parvum Dihydrofolate Reductase Inhibitors by Complementation in Saccharomyces cerevisiae Victoria Hertle Brophy, John Vasquez, Richard G. Nelson, John R. Forney, Andre Rosowsky, and Carol Hopkins Sibley Antimicrob. Agents Chemother. April 2000 44: 1019-1028; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Nontraditional Antimicrobials against Multiresistant Acinetobacter baumannii Strains Isolated in an Intensive Care Unit Outbreak Maria D. Appleman, Howard Belzberg, Diane M. Citron, Peter N. R. Heseltine, Albert E. Yellin, James Murray, and Thomas V. Berne Antimicrob. Agents Chemother. April 2000 44: 1035-1040; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Daptomycin, Vancomycin, Linezolid, and Quinupristin-Dalfopristin against Staphylococci and Enterococci, Including Vancomycin- Intermediate and -Resistant Strains Michael J. Rybak, Ellie Hershberger, Tabitha Moldovan, and Richard G. Grucz Antimicrob. Agents Chemother. April 2000 44: 1062-1066; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antipneumococcal Activities of GAR-936 (a New Glycylcycline) Compared to Those of Nine Other Agents against Penicillin-Susceptible and -Resistant Pneumococci Dianne B. Hoellman, Glenn A. Pankuch, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. April 2000 44: 1085-1088; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Canadian National Surveillance Study of Urinary Tract Isolates from Outpatients: Comparison of the Activities of Trimethoprim-Sulfamethoxazole, Ampicillin, Mecillinam, Nitrofurantoin, and Ciprofloxacin George G. Zhanel, James A. Karlowsky, Godfrey K. M. Harding, Anita Carrie, Tony Mazzulli, Donald E. Low, The Canadian Urinary Isolate Study Group, and Daryl J. Hoban Antimicrob. Agents Chemother. April 2000 44: 1089-1092; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Sitafloxacin (DU-6859a) and Six Other Fluoroquinolones against 8,796 Clinical Bacterial Isolates Dana Milatovic, Franz-Josef Schmitz, Sylvain Brisse, Jan Verhoef, and Ad C. Fluit Antimicrob. Agents Chemother. April 2000 44: 1102-1107; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of ABT 773, a New Ketolide Antibiotic, against Chlamydia pneumoniae Sebastian Strigl, Patricia M. Roblin, Tamara Reznik, and Margaret R. Hammerschlag Antimicrob. Agents Chemother. April 2000 44: 1112-1113; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Intracellular Metabolism of -L-2',3'-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity Laurent Placidi, Erika Cretton-Scott, Gilles Gosselin, Claire Pierra, Raymond F. Schinazi, Jean-Louis Imbach, Mahmoud H. el Kouni, and Jean-Pierre Sommadossi Antimicrob. Agents Chemother. April 2000 44: 853-858; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Broad-Spectrum Antiviral Activity of the IMP Dehydrogenase Inhibitor VX-497: a Comparison with Ribavirin and Demonstration of Antiviral Additivity with Alpha Interferon W. Markland, T. J. McQuaid, J. Jain, and A. D. Kwong Antimicrob. Agents Chemother. April 2000 44: 859-866; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Rapid Phenotypic Assay for Detection of Acyclovir-Resistant Varicella-Zoster Virus with Mutations in the Thymidine Kinase Open Reading Frame Roland Sahli, Graciela Andrei, Christine Estrade, Robert Snoeck, and Pascal R. A. Meylan Antimicrob. Agents Chemother. April 2000 44: 873-878; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Phenotypic Drug Susceptibility Assay for Human Immunodeficiency Virus Type 1 Christos J. Petropoulos, Neil T. Parkin, Kay L. Limoli, Yolanda S. Lie, Terri Wrin, Wei Huang, Huan Tian, Douglas Smith, Genine A. Winslow, Daniel J. Capon, and Jeannette M. Whitcomb Antimicrob. Agents Chemother. April 2000 44: 920-928; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus Jean Bedard, Suzanne May, Lucille L'Heureux, Thomas Stamminger, Alice Copsey, John Drach, John Huffman, Laval Chan, Haolun Jin, and Robert F. Rando Antimicrob. Agents Chemother. April 2000 44: 929-937; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1 Walter T. Hughes, Jerry L. Shenep, John H. Rodman, Arnold Fridland, Rodney Willoughby, Suzette Blanchard, Lynette Purdue, Dion F. Coakley, Kenneth C. Cundy, Mary Culnane, Bonnie Zimmer, Sandra Burchett, Jennifer S. Read, and The Pediatric AIDS Clinical Trials Group Antimicrob. Agents Chemother. April 2000 44: 1041-1046; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic Stuart Snyder, D. Z. D'Argenio, Owen Weislow, John A. Bilello, and G. L. Drusano Antimicrob. Agents Chemother. April 2000 44: 1051-1058; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Toward Antiviral Strategies That Resist Viral Escape Drew Endy and John Yin Antimicrob. Agents Chemother. April 2000 44: 1097-1099; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Efficacies of Imipenem, Meropenem, Cefepime, and Ceftazidime in Rats with Experimental Pneumonia Due to a Carbapenem-Hydrolyzing -Lactamase-Producing Strain of Enterobacter cloacae Olivier Mimoz, Sophie Leotard, Anne Jacolot, Christophe Padoin, Kamel Louchahi, Olivier Petitjean, and Patrice Nordmann Antimicrob. Agents Chemother. April 2000 44: 885-890; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Activity and Pharmacokinetics of Ziracin (SCH27899), a New Long-Acting Everninomicin Antibiotic, in a Murine Model of Penicillin-Susceptible or Penicillin-Resistant Pneumococcal Pneumonia Erjian Wang, Marie Simard, Yves Bergeron, Denis Beauchamp, and Michel G. Bergeron Antimicrob. Agents Chemother. April 2000 44: 1010-1018; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Coordinate Suppression of Superantigen-Induced Cytokine Production and T-Cell Proliferation by a Small Nonpeptidic Inhibitor of Class II Major Histocompatibility Complex and CD4 Interaction Teresa Krakauer Antimicrob. Agents Chemother. April 2000 44: 1067-1069; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Control of Staphylococcal Adhesion to Polymethylmethacrylate and Enhancement of Susceptibility to Antibiotics by Poloxamer 407 Marie-Laure Veyries, Francois Faurisson, Marie-Laure Joly-Guillou, and Bernard Rouveix Antimicrob. Agents Chemother. April 2000 44: 1093-1096; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Recent Approvals:

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New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 1999 and New Indications for Previously Approved Agents Antimicrob. Agents Chemother. April 2000 44: 1114-1115; [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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An Invasive Isolate of Neisseria meningitidis Showing Decreased Susceptibility to Quinolones T. R. Shultz, J. W. Tapsall, P. A. White, and P. J. Newton Antimicrob. Agents Chemother. April 2000 44: 1116 [Full Text] [PDF] [Reprints and Permissions]

Antiretroviral-Drug Concentrations in Semen Keith Gallicano; and Angela D. M. Kashuba Antimicrob. Agents Chemother. April 2000 44: 1117-1118; [Full Text] [PDF] [Reprints and Permissions]

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Author's Correction:

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Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1 Angela D. M. Kashuba, John R. Dyer, Linda M. Kramer, Ralph H. Raasch, Joseph J. Eron, and Myron S. Cohen Antimicrob. Agents Chemother. April 2000 44: 1119 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.