Contents: August 2000, Volume 44, Issue 8        Minireviews        Experimental Therapeutics        Mechanisms of Resistance        Clinical Therapeutics        Susceptibility        Pharmacology        Antiviral Agents        Mechanisms of Action        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Impact of Antimicrobial Agents and Chemotherapy from 1972 to 1998 Morton N. Swartz Antimicrob. Agents Chemother. August 2000 44: 2009-2016; [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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In Vitro and In Vivo Activities of SCH 56592 (Posaconazole), a New Triazole Antifungal Agent, against Aspergillus and Candida Anthony Cacciapuoti, David Loebenberg, Erik Corcoran, Fred Menzel, Jr., Eugene L. Moss, Jr., Christine Norris, Monika Michalski, Kimberly Raynor, Judith Halpern, Cara Mendrick, Brian Arnold, Barry Antonacci, Raulo Parmegiani, Taisa Yarosh-Tomaine, George H. Miller, and Roberta S. Hare Antimicrob. Agents Chemother. August 2000 44: 2017-2022; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activity of Gentamicin against Enterococcus faecalis In Vitro and In Vivo Agnès Lefort, Michel Arthur, Louis Garry, Claude Carbon, Patrice Courvalin, and Bruno Fantin Antimicrob. Agents Chemother. August 2000 44: 2077-2080; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergy between Trovafloxacin and Ceftriaxone against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model and In Vitro Philippe Cottagnoud, Fernando Acosta, Marianne Cottagnoud, Klaus Neftel, and Martin G. Täuber Antimicrob. Agents Chemother. August 2000 44: 2179-2181; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Amino Acid Substitutions in a Variant of IMP-1 Metallo--Lactamase Shizuko Iyobe, Haruko Kusadokoro, Junko Ozaki, Naoki Matsumura, Shinzaburo Minami, Shin Haruta, Tetsuo Sawai, and Koji O'Hara Antimicrob. Agents Chemother. August 2000 44: 2023-2027; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-Lactamases in Shigella flexneri Isolates from Hong Kong and Shanghai and a Novel OXA-1-Like -Lactamase, OXA-30 L. K. Siu, J. Y. C. Lo, K. Y. Yuen, P. Y. Chau, M. H. Ng, and P. L. Ho Antimicrob. Agents Chemother. August 2000 44: 2034-2038; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Plasmodium falciparum Cytochrome b That Are Associated with Atovaquone Resistance Are Located at a Putative Drug-Binding Site Michael Korsinczky, Nanhua Chen, Barbara Kotecka, Allan Saul, Karl Rieckmann, and Qin Cheng Antimicrob. Agents Chemother. August 2000 44: 2100-2108; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide Passage A. Tait-Kamradt, T. Davies, M. Cronan, M. R. Jacobs, P. C. Appelbaum, and J. Sutcliffe Antimicrob. Agents Chemother. August 2000 44: 2118-2125; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of rdxA and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of Helicobacter pylori Dong-Hyeon Kwon, Fouad A. K. El-Zaatari, Mototsugu Kato, Michael S. Osato, Rita Reddy, Yoshio Yamaoka, and David Y. Graham Antimicrob. Agents Chemother. August 2000 44: 2133-2142; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance and Spread of Class 1 Integrons among Salmonella Serotypes Beatriz Guerra, Sara Soto, Santiago Cal, and M. Carmen Mendoza Antimicrob. Agents Chemother. August 2000 44: 2166-2169; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection of Naturally Occurring Extended-Spectrum TEM -Lactamase Variants by Fluctuating -Lactam Pressure Jesús Blazquez, María-Isabel Morosini, María-Cristina Negri, and Fernando Baquero Antimicrob. Agents Chemother. August 2000 44: 2182-2184; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Resistance Associated with Target Mutations and Active Efflux in Oropharyngeal Colonizing Isolates of Viridans Group Streptococci François Guerin, Emmanuelle Varon, Annie Buu Hoï, Laurent Gutmann, and Isabelle Podglajen Antimicrob. Agents Chemother. August 2000 44: 2197-2200; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical-Genetic Characterization and Distribution of OXA-22, a Chromosomal and Inducible Class D -Lactamase from Ralstonia (Pseudomonas) pickettii Patrice Nordmann, Laurent Poirel, Maryline Kubina, Anne Casetta, and Thierry Naas Antimicrob. Agents Chemother. August 2000 44: 2201-2204; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Metronidazole Resistance in Helicobacter pylori: Comparison of the rdxA Gene Sequences in 30 Strains Nadia Maggi Solcà, Marco Valerio Bernasconi, and Jean-Claude Piffaretti Antimicrob. Agents Chemother. August 2000 44: 2207-2210; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Monotherapy with a Broad-Spectrum Beta-Lactam Is as Effective as Its Combination with an Aminoglycoside in Treatment of Severe Generalized Peritonitis: a Multicenter Randomized Controlled Trial H. Dupont and C. Carbon Antimicrob. Agents Chemother. August 2000 44: 2028-2033; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Characterization of a Fish Antimicrobial Peptide: Gene Expression, Subcellular Localization, and Spectrum of Activity Alexander M. Cole, Rabih O. Darouiche, Diana Legarda, Nancy Connell, and Gill Diamond Antimicrob. Agents Chemother. August 2000 44: 2039-2045; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibilities and Clinical Sources of Facklamia Species L. LaClaire and R. Facklam Antimicrob. Agents Chemother. August 2000 44: 2130-2132; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Saccharomicins, Novel Heptadecaglycoside Antibiotics Produced by Saccharothrix espanaensis: Antibacterial and Mechanistic Activities M. P. Singh, P. J. Petersen, W. J. Weiss, F. Kong, and M. Greenstein Antimicrob. Agents Chemother. August 2000 44: 2154-2159; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Gemifloxacin versus Five Quinolones and Two Macrolides against 271 Spanish Isolates of Legionella pneumophila: Influence of Charcoal on Susceptibility Test Results M. T. García, C. Pelaz, M. J. Giménez, and L. Aguilar Antimicrob. Agents Chemother. August 2000 44: 2176-2178; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility Testing of Malassezia Species Using the Urea Broth Microdilution Method Yuka Nakamura, Rui Kano, Tae Murai, Shinichi Watanabe, and Atsuhiko Hasegawa Antimicrob. Agents Chemother. August 2000 44: 2185-2186; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of n-6 Polyunsaturated Fatty Acids on Growth of Multidrug-Resistant Pseudomonas aeruginosa: Interactions with Amikacin and Ceftazidime E. J. Giamarellos-Bourboulis, P. Grecka, A. Dionyssiou-Asteriou, and H. Giamarellou Antimicrob. Agents Chemother. August 2000 44: 2187-2189; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Reversion of Amphotericin B Resistance in Leishmania donovani by Poloxamer 188 S. Espuelas, P. Legrand, P. M. Loiseau, C. Bories, G. Barratt, and J. M. Irache Antimicrob. Agents Chemother. August 2000 44: 2190-2192; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates from Pediatric Patients in Singapore Shirlena Wee-Ling Soh, Chit Laa Poh, and Raymond V. Tzer Pin Lin Antimicrob. Agents Chemother. August 2000 44: 2193-2196; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Epidemiologically Defined Acinetobacter baumannii Strains Barbara Heinemann, Hilmar Wisplinghoff, Michael Edmond, and Harald Seifert Antimicrob. Agents Chemother. August 2000 44: 2211-2213; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Regional Differences in Metronidazole Resistance and Increasing Clarithromycin Resistance among Helicobacter pylori Isolates from Japan Mototsugu Kato, Yoshio Yamaoka, Jae J. Kim, Rita Reddy, Masahiro Asaka, Kei Kashima, Michael S. Osato, Fouad A. K. El-Zaatari, David Y. Graham, and Dong H. Kwon Antimicrob. Agents Chemother. August 2000 44: 2214-2216; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimicrobial Activities of Novel Anilinouracils Which Selectively Inhibit DNA Polymerase III of Gram-Positive Bacteria Jennifer S. Daly, Theodore J. Giehl, Neal C. Brown, Chengxin Zhi, George E. Wright, and Richard T. Ellison, III Antimicrob. Agents Chemother. August 2000 44: 2217-2221; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of MK-826 (L-749,345) against 363 Strains of Anaerobic Bacteria Hannah M. Wexler, Denise Molitoris, and Sydney M. Finegold Antimicrob. Agents Chemother. August 2000 44: 2222-2224; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the Glycylcycline GAR-936 against Gram-Positive Bacteria Helen W. Boucher, Christine B. Wennersten, and George M. Eliopoulos Antimicrob. Agents Chemother. August 2000 44: 2225-2229; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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A Population Pharmacokinetic Analysis of the Penetration of the Prostate by Levofloxacin G. L. Drusano, S. L. Preston, M. Van Guilder, D. North, M. Gombert, M. Oefelein, L. Boccumini, B. Weisinger, M. Corrado, and J. Kahn Antimicrob. Agents Chemother. August 2000 44: 2046-2051; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dose-Dependent Pharmacokinetics of Amphotericin B Lipid Complex in Rabbits Thomas J. Walsh, Andre J. Jackson, James W. Lee, Michael Amantea, Tin Sein, John Bacher, and Loren Zech Antimicrob. Agents Chemother. August 2000 44: 2068-2076; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Single-Dose Oral Stavudine in Subjects with Renal Impairment and in Subjects Requiring Hemodialysis Dennis M. Grasela, Randall R. Stoltz, Michael Barry, Michael Bone, Bernhard Mangold, Padraig O'Grady, Ralph Raymond, and Stephen J. Haworth Antimicrob. Agents Chemother. August 2000 44: 2149-2153; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Fluconazole and Clarithromycin on Rifabutin and 25-O-Desacetylrifabutin Pharmacokinetics M. Kelli Jordan, Michael A. Polis, Grace Kelly, Prem K. Narang, Henry Masur, and Stephen C. Piscitelli Antimicrob. Agents Chemother. August 2000 44: 2170-2172; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Indinavir Population Pharmacokinetics in Plasma and Cerebrospinal Fluid Scott L. Letendre, Edmund V. Capparelli, Ronald J. Ellis, J. Allen McCutchan, and The HIV NEUROBEHAVIORAL RESEARCH CENTER GROUP Antimicrob. Agents Chemother. August 2000 44: 2173-2175; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity and Fecal Concentration of Rifaximin after Oral Administration Zhi-Dong Jiang, Shi Ke, Ernesto Palazzini, Lise Riopel, and Herbert Dupont Antimicrob. Agents Chemother. August 2000 44: 2205-2206; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Population Pharmacokinetics and Pharmacodynamic Modeling of Abacavir (1592U89) from a Dose-Ranging, Double-Blind, Randomized Monotherapy Trial with Human Immunodeficiency Virus-Infected Subjects Stephen Weller, Kristine M. Radomski, Yu Lou, and Daniel S. Stein Antimicrob. Agents Chemother. August 2000 44: 2052-2060; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple-Dose Pharmacokinetics and Pharmacodynamics of Abacavir Alone and in Combination with Zidovudine in Human Immunodeficiency Virus-Infected Adults James A. McDowell, Yu Lou, William S. Symonds, and Daniel S. Stein Antimicrob. Agents Chemother. August 2000 44: 2061-2067; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents Brett S. Robinson, Keith A. Riccardi, Yi-fei Gong, Qi Guo, David A. Stock, Wade S. Blair, Brian J. Terry, Carol A. Deminie, Fred Djang, Richard J. Colonno, and Pin-fang Lin Antimicrob. Agents Chemother. August 2000 44: 2093-2099; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence and Characteristics of Multinucleoside-Resistant Human Immunodeficiency Virus Type 1 among European Patients Receiving Combinations of Nucleoside Analogues Kristien Van Vaerenbergh, Kristel Van Laethem, Jan Albert, Charles A. B. Boucher, Bonaventura Clotet, Marco Floridia, Jan Gerstoft, Bo Hejdeman, Claus Nielsen, Christophe Pannecouque, Luc Perrin, Maria F. Pirillo, Lidia Ruiz, Jean-Claude Schmit, François Schneider, Anne Schoolmeester, Rob Schuurman, Hans J. Stellbrink, Lieven Stuyver, Jan Van Lunzen, Barbara Van Remoortel, Eric Van Wijngaerden, Stefano Vella, Myriam Witvrouw, Sabine Yerly, Erik De Clercq, Jan Desmyter, and Anne-Mieke Vandamme Antimicrob. Agents Chemother. August 2000 44: 2109-2117; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Double-Blind Placebo-Controlled Crossover Trial of Intravenous Magnesium Sulfate for Foscarnet-Induced Ionized Hypocalcemia and Hypomagnesemia in Patients with AIDS and Cytomegalovirus Infection Mark M. Huycke, M. Tarek Naguib, Mathias M. Stroemmel, Kenneth Blick, Katherine Monti, Sarah Martin-Munley, and Chris Kaufman Antimicrob. Agents Chemother. August 2000 44: 2143-2148; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Quantitation of Candida albicans Ergosterol Content Improves the Correlation between In Vitro Antifungal Susceptibility Test Results and In Vivo Outcome after Fluconazole Treatment in a Murine Model of Invasive Candidiasis Beth A. Arthington-Skaggs, David W. Warnock, and Christine J. Morrison Antimicrob. Agents Chemother. August 2000 44: 2081-2085; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria Carol L. Friedrich, Dianne Moyles, Terry J. Beveridge, and Robert E. W. Hancock Antimicrob. Agents Chemother. August 2000 44: 2086-2092; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimycobacterial Activities of Novel Levofloxacin Analogues Katsuhiro Kawakami, Kenji Namba, Mayumi Tanaka, Norikazu Matsuhashi, Kenichi Sato, and Makoto Takemura Antimicrob. Agents Chemother. August 2000 44: 2126-2129; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus: Different Patterns of Quinolone- Induced Inhibition of DNA Synthesis Bénédicte Fournier, Xilin Zhao, Tao Lu, Karl Drlica, and David C. Hooper Antimicrob. Agents Chemother. August 2000 44: 2160-2165; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Are SHV -Lactamases Universal in Klebsiella pneumoniae? Gioia S. Babini and David M. Livermore Antimicrob. Agents Chemother. August 2000 44: 2230 [Full Text] [PDF] [Reprints and Permissions]

Linkage of vat(E) and erm(B) in Streptogramin-Resistant Enterococcus faecium Isolates from Europe Lars Bogø Jensen, Anette M. Hammerum, and Frank M. Aarestrup Antimicrob. Agents Chemother. August 2000 44: 2231-2232; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.