Contents: February 2001, Volume 45, Issue 2        Minireviews        Pharmacology        Antiviral Agents        Biologic Response Modifiers        Mechanisms of Action        Mechanisms of Resistance        Experimental Therapeutics        Clinical Therapeutics        Susceptibility        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Regulation of VanA- and VanB-Type Glycopeptide Resistance in Enterococci Michel Arthur and Richard Quintiliani, Jr. Antimicrob. Agents Chemother. February 2001 45: 375-381; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Inhibition of Cytochrome P450 (CYP450) Isoforms by Isoniazid: Potent Inhibition of CYP2C19 and CYP3A Zeruesenay Desta, Nadia V. Soukhova, and David A. Flockhart Antimicrob. Agents Chemother. February 2001 45: 382-392; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic Interaction between Amprenavir and Rifabutin or Rifampin in Healthy Males Ronald E. Polk, Donald F. Brophy, Debra S. Israel, Roberto Patron, Brian M. Sadler, Gregory E. Chittick, William T. Symonds, Yu Lou, Debbie Kristoff, and D. S. Stein Antimicrob. Agents Chemother. February 2001 45: 502-508; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria Sanjeev Krishna, Tim Planche, Tsiri Agbenyega, Charles Woodrow, Dan Agranoff, George Bedu-Addo, Alex K. Owusu-Ofori, John Adabie Appiah, Surash Ramanathan, Sharif M. Mansor, and Visweswaran Navaratnam Antimicrob. Agents Chemother. February 2001 45: 509-516; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection Jeffrey M. Jacobson, Lawrence Feinman, Leonard Liebes, Nancy Ostrow, Victoria Koslowski, Alfonso Tobia, Bernard E. Cabana, Dong-Hun Lee, John Spritzler, and Alfred M. Prince Antimicrob. Agents Chemother. February 2001 45: 517-524; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple-Dose Pharmacokinetics and Tolerability of Gemifloxacin Administered Orally to Healthy Volunteers Ann Allen, Elizabeth Bygate, Marika Vousden, Stuart Oliver, Martin Johnson, Christopher Ward, Ae-Jin Cheon, Youn Sung Choo, and In-Chull Kim Antimicrob. Agents Chemother. February 2001 45: 540-545; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Compartmental Pharmacokinetics of the Antifungal Echinocandin Caspofungin (MK-0991) in Rabbits Andreas H. Groll, Bryan M. Gullick, Ruta Petraitiene, Vidmantas Petraitis, Myrna Candelario, Stephen C. Piscitelli, and Thomas J. Walsh Antimicrob. Agents Chemother. February 2001 45: 596-600; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits Karl V. Clemons, Raymond A. Sobel, Paul L. Williams, and David A. Stevens Antimicrob. Agents Chemother. February 2001 45: 612-615; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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SJ-3366, a Unique and Highly Potent Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) That Also Inhibits HIV-2 Robert W. Buckheit, Jr., Karen Watson, Valerie Fliakas-Boltz, Julie Russell, Tracy L. Loftus, Mark C. Osterling, Jim A. Turpin, Luke A. Pallansch, E. Lucile White, J.-W. Lee, S.-H. Lee, J.-W. Oh, H.-S. Kwon, S.-G. Chung, and E.-H. Cho Antimicrob. Agents Chemother. February 2001 45: 393-400; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid and Simple Phenotypic Assay for Drug Susceptibility of Human Immunodeficiency Virus Type 1 Using CCR5-Expressing HeLa/CD4+ Cell Clone 1-10 (MAGIC-5) Atsuko Hachiya, Saori Aizawa-Matsuoka, Mari Tanaka, Yukiko Takahashi, Setsuko Ida, Hiroyuki Gatanaga, Yoshihiro Hirabayashi, Asato Kojima, Masashi Tatsumi, and Shinichi Oka Antimicrob. Agents Chemother. February 2001 45: 495-501; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Prior Exposure to Zidovudine on Stavudine Phosphorylation In Vivo and Ex Vivo P. G. Hoggard, S. D. Sales, D. Phiboonbanakit, J. Lloyd, B. A. Maher, S. H. Khoo, E. Wilkins, P. Carey, C. A. Hart, and D. J. Back Antimicrob. Agents Chemother. February 2001 45: 577-582; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Multiple Human Cytomegalovirus Ganciclovir-Resistant Mutants with Deletions and Substitutions within the UL97 Gene in a Patient with Severe Combined Immunodeficiency Dana G. Wolf, Isaac Yaniv, Shai Ashkenazi, and Alik Honigman Antimicrob. Agents Chemother. February 2001 45: 593-595; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Erythromycin Modulates Eosinophil Chemotactic Cytokine Production by Human Lung Fibroblasts in Vitro Etsuro Sato, Dan K. Nelson, Sekiya Koyama, Jeffrey C. Hoyt, and Richard A. Robbins Antimicrob. Agents Chemother. February 2001 45: 401-406; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Antibodies to Bacterial Superantigens and Their Ability To Inhibit T-Cell Activation and Lethality Ross D. LeClaire and Sina Bavari Antimicrob. Agents Chemother. February 2001 45: 460-463; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduction of NO Synthase Expression and Tumor Necrosis Factor Alpha Production in Macrophages by Amphotericin B Lipid Carriers Malika Larabi, Philippe Legrand, Martine Appel, Sophie Gil, Michel Lepoivre, Jean-Philippe Devissaguet, Francis Puisieux, and Gillian Barratt Antimicrob. Agents Chemother. February 2001 45: 553-562; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Therapeutic Potential of Human Neutrophil Peptide 1 against Experimental Tuberculosis Sudhir Sharma, Indu Verma, and G. K. Khuller Antimicrob. Agents Chemother. February 2001 45: 639-640; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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The AbcA Transporter of Staphylococcus aureus Affects Cell Autolysis Gesine Schrader-Fischer and Brigitte Berger-Bächi Antimicrob. Agents Chemother. February 2001 45: 407-412; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Affinity Binding of Silybin Derivatives to the Nucleotide-Binding Domain of a Leishmania tropica P-Glycoprotein-Like Transporter and Chemosensitization of a Multidrug-Resistant Parasite to Daunomycin José M. Pérez-Victoria, F. Javier Pérez-Victoria, Gwenaëlle Conseil, Mathias Maitrejean, Gilles Comte, Denis Barron, Attilio Di Pietro, Santiago Castanys, and Francisco Gamarro Antimicrob. Agents Chemother. February 2001 45: 439-446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin Brunello Oliva, Alexander O'Neill, Jenny M. Wilson, Peter J. O'Hanlon, and Ian Chopra Antimicrob. Agents Chemother. February 2001 45: 532-539; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Plasmid Location and Molecular Heterogeneity of the L1 and L2 -Lactamase Genes of Stenotrophomonas maltophilia Matthew B. Avison, Catherine S. Higgins, Charlotte J. von Heldreich, Peter M. Bennett, and Timothy R. Walsh Antimicrob. Agents Chemother. February 2001 45: 413-419; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dynamic and Heterogeneous Mutations to Fluconazole Resistance in Cryptococcus neoformans Jianping Xu, Chiatogu Onyewu, Heather J. Yoell, Rabia Y. Ali, Rytas J. Vilgalys, and Thomas G. Mitchell Antimicrob. Agents Chemother. February 2001 45: 420-427; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ Rungtip Chuanchuen, Kerry Beinlich, Tung T. Hoang, Anna Becher, RoxAnn R. Karkhoff-Schweizer, and Herbert P. Schweizer Antimicrob. Agents Chemother. February 2001 45: 428-432; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of Streptococcus pneumoniae Joseph M. Blondeau, Xilin Zhao, Glen Hansen, and Karl Drlica Antimicrob. Agents Chemother. February 2001 45: 433-438; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

OXA-28, an Extended-Spectrum Variant of OXA-10 -Lactamase from Pseudomonas aeruginosa and Its Plasmid- and Integron-Located Gene Laurent Poirel, Delphine Girlich, Thierry Naas, and Patrice Nordmann Antimicrob. Agents Chemother. February 2001 45: 447-453; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Carbapenem Resistance Mechanisms in Pseudomonas aeruginosa Clinical Isolates Hyunjoo Pai, Jong-Won Kim, Jungmin Kim, Ji Hyang Lee, Kang Won Choe, and Naomasa Gotoh Antimicrob. Agents Chemother. February 2001 45: 480-484; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Class 1 Integrons from Pseudomonas aeruginosa That Contain the blaVIM-2 Carbapenem-Hydrolyzing -Lactamase Gene and of Two Novel Aminoglycoside Resistance Gene Cassettes Laurent Poirel, Thierry Lambert, Salih Türkoglü, Esthel Ronco, Jean-Louis Gaillard, and Patrice Nordmann Antimicrob. Agents Chemother. February 2001 45: 546-552; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of OXA-25, OXA-26, and OXA-27, Molecular Class D -Lactamases Associated with Carbapenem Resistance in Clinical Isolates of Acinetobacter baumannii Mariya Afzal-Shah, Neil Woodford, and David M. Livermore Antimicrob. Agents Chemother. February 2001 45: 583-588; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nucleotide Sequence and Characterization of a Novel Cefotaxime-Hydrolyzing -Lactamase (CTX-M-10) Isolated in Spain Antonio Oliver, José Claudio Pérez-Díaz, Teresa M. Coque, Fernando Baquero, and Rafael Cantón Antimicrob. Agents Chemother. February 2001 45: 616-620; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Macrolide Resistance in Peptostreptococcus spp. Mediated by ermTR: Possible Source of Macrolide-Lincosamide-Streptogramin B Resistance in Streptococcus pyogenes Milagro Reig, Juan-Carlos Galan, Fernando Baquero, and Jose Claudio Perez-Diaz Antimicrob. Agents Chemother. February 2001 45: 630-632; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Macrolide Resistance in Clinical Pneumococcal Isolates in France Frederic Fitoussi, Catherine Doit, Pierre Geslin, Naima Brahimi, and Edouard Bingen Antimicrob. Agents Chemother. February 2001 45: 636-638; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Bactericidal Activities of Two Daptomycin Regimens against Clinical Strains of Glycopeptide Intermediate-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus faecium, and Methicillin-Resistant Staphylococcus aureus Isolates in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations Ronda L. Akins and Michael J. Rybak Antimicrob. Agents Chemother. February 2001 45: 454-459; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Therapeutic Efficacy of Liposome-Encapsulated Gentamicin in Rat Klebsiella pneumoniae Pneumonia in Relation to Impaired Host Defense and Low Bacterial Susceptibility to Gentamicin Raymond M. Schiffelers, Gert Storm, Marian T. ten Kate, and Irma A. J. M. Bakker-Woudenberg Antimicrob. Agents Chemother. February 2001 45: 464-470; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dosage-Dependent Antifungal Efficacy of V-Echinocandin (LY303366) against Experimental Fluconazole-Resistant Oropharyngeal and Esophageal Candidiasis Vidmantas Petraitis, Ruta Petraitiene, Andreas H. Groll, Tin Sein, Robert L. Schaufele, Caron A. Lyman, Andrea Francesconi, John Bacher, Stephen C. Piscitelli, and Thomas J. Walsh Antimicrob. Agents Chemother. February 2001 45: 471-479; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of the Order of Initiation of Fluconazole and Amphotericin B in Sequential or Combination Therapy on Killing of Candida albicans In Vitro and in a Rabbit Model of Endocarditis and Pyelonephritis Arnold Louie, Pamela Kaw, Partha Banerjee, Weiguo Liu, George Chen, and Michael H. Miller Antimicrob. Agents Chemother. February 2001 45: 485-494; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor John M. Clements, R. Paul Beckett, Anthony Brown, Graham Catlin, Mario Lobell, Shilpa Palan, Wayne Thomas, Mark Whittaker, Stephen Wood, Sameeh Salama, Patrick J. Baker, H. Fiona Rodgers, Vladimir Barynin, David W. Rice, and Michael G. Hunter Antimicrob. Agents Chemother. February 2001 45: 563-570; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Selection of Multidrug Efflux Mutants by Trovafloxacin and Ciprofloxacin in an Experimental Model of Pseudomonas aeruginosa Acute Pneumonia in Rats O. F. Join-Lambert, M. Michéa-Hamzehpour, T. Köhler, F. Chau, F. Faurisson, S. Dautrey, C. Vissuzaine, C. Carbon, and J.-C. Pechère Antimicrob. Agents Chemother. February 2001 45: 571-576; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Voriconazole in Treatment of Murine Pulmonary Blastomycosis Alan M. Sugar and Xiu-Ping Liu Antimicrob. Agents Chemother. February 2001 45: 601-604; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Linezolid Therapy of Vancomycin-Resistant Enterococcus faecium Experimental Endocarditis Robin Patel, Mark S. Rouse, Kerryl E. Piper, and James M. Steckelberg Antimicrob. Agents Chemother. February 2001 45: 621-623; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Clinafloxacin versus Piperacillin-Tazobactam in Treatment of Patients with Severe Skin and Soft Tissue Infections G. Siami, N. Christou, I. Eiseman, K. J. Tack, and the Clinafloxacin Severe Skin And Soft Tissue Infections Study Group Antimicrob. Agents Chemother. February 2001 45: 525-531; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Single Oral Doses of Gemifloxacin (320 Milligrams) versus Trovafloxacin (200 Milligrams) on Fecal Flora in Healthy Volunteers Gloria Garcia-Calvo, Ana Molleja, Maria J. Giménez, Araceli Parra, Eva Nieto, Carmen Ponte, Lorenzo Aguilar, and Francisco Soriano Antimicrob. Agents Chemother. February 2001 45: 608-611; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Comparative Antianaerobic Activity of BMS 284756 Dianne B. Hoellman, Linda M. Kelly, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. February 2001 45: 589-592; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Germinated and Nongerminated Conidial Suspensions for Testing of Susceptibilities of Aspergillus spp. to Amphotericin B, Itraconazole, Posaconazole, Ravuconazole, and Voriconazole A. Espinel-Ingroff Antimicrob. Agents Chemother. February 2001 45: 605-607; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the New Ketolide HMR 3647 (Telithromycin) in Comparison with Those of Eight Other Antibiotics against Viridans Group Streptococci Isolated from Blood of Neutropenic Patients with Cancer Fernando Alcaide, Miguel Angel Benítez, Jordi Carratalà, Francesc Gudiol, Josefina Liñares, and Rogelio Martín Antimicrob. Agents Chemother. February 2001 45: 624-626; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Two-Year Surveillance of Antibiotic Resistance in Streptococcus pneumoniae in Four African Cities Mohamed Benbachir, Saida Benredjeb, Cheick Saadbouh Boye, Mireille Dosso, Houria Belabbes, Aouatef Kamoun, Omar Kaire, and Naima Elmdaghri Antimicrob. Agents Chemother. February 2001 45: 627-629; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Approved and Investigational Antifungal Agents against 44 Clinical Isolates of Basidiomycetous Fungi Gloria M. González, Deanna A. Sutton, Elizabeth Thompson, Rolando Tijerina, and Michael G. Rinaldi Antimicrob. Agents Chemother. February 2001 45: 633-635; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Characterization of the mupA Gene in Strains of Methicillin-Resistant Staphylococcus aureus with a Low Level of Resistance to Mupirocin Shigeru Fujimura, Akira Watanabe, and David Beighton Antimicrob. Agents Chemother. February 2001 45: 641-642; [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Rifaximin against Enteropathogens Producing Traveler's Diarrhea Josep M. Sierra, Joaquin Ruiz, Margarita M. Navia, Martha Vargas, Joaquim Gascon, and Jordi Vila Antimicrob. Agents Chemother. February 2001 45: 643-644; [Full Text] [PDF] [Reprints and Permissions]

Identification of vat(E-3), a Novel Gene Encoding Resistance to Quinupristin-Dalfopristin in a Strain of Enterococcus faecium from a Hospital Patient in the United Kingdom Mehnam Soltani, David Beighton, John Philpott-Howard, and Neil Woodford Antimicrob. Agents Chemother. February 2001 45: 645-646; [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Dihydropteroate Synthase of Mycobacterium leprae and Dapsone Resistance Diana L. Williams, Laynette Spring, Eugene Harris, Paul Roche, and Thomas P. Gillis Antimicrob. Agents Chemother. February 2001 45: 647 [Full Text] [PDF] [Reprints and Permissions]

High-Level Fluoroquinolone-Resistant Clinical Isolates of Escherichia coli Overproduce Multidrug Efflux Protein AcrA Annarita Mazzariol, Yutaka Tokue, Tiffany M. Kanegawa, Giuseppe Cornaglia, and Hiroshi Nikaido Antimicrob. Agents Chemother. February 2001 45: 647 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.