Contents: April 2001, Volume 45, Issue 4        Minireviews        Experimental Therapeutics        Antiviral Agents        Mechanisms of Resistance        Susceptibility        Mechanisms of Action        Clinical Therapeutics        Biologic Response Modifiers        Pharmacology        Recent Approvals        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Minireviews:

---

Riddle of Biofilm Resistance Kim Lewis Antimicrob. Agents Chemother. April 2001 45: 999-1007; [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Antifungal Efficacy of GM237354, a Sordarin Derivative, in Experimental Oral Candidiasis in Immunosuppressed Rats Antonio Martinez, Javier Regadera, Elena Jimenez, Inmaculada Santos, and Domingo Gargallo-Viola Antimicrob. Agents Chemother. April 2001 45: 1008-1013; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penicillin Pharmacodynamics in Four Experimental Pneumococcal Infection Models Helga Erlendsdottir, Jenny Dahl Knudsen, Inga Odenholt, Otto Cars, Frank Espersen, Niels Frimodt-Møller, Kurt Fuursted, Karl G. Kristinsson, and Sigurdur Gudmundsson Antimicrob. Agents Chemother. April 2001 45: 1078-1085; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of the Combination of Quinupristin-Dalfopristin with Rifampin In Vitro and in Experimental Endocarditis Due to Staphylococcus aureus Strains with Various Phenotypes of Resistance to Macrolide-Lincosamide-Streptogramin Antibiotics Virginie Zarrouk, Bülent Bozdogan, Roland Leclercq, Louis Garry, Celine Feger, Claude Carbon, and Bruno Fantin Antimicrob. Agents Chemother. April 2001 45: 1244-1248; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and in Vivo Combinations of Cefotaxime and Minocycline against Aeromonas hydrophila Wen-Chien Ko, Hsin-Chun Lee, Yin-Ching Chuang, Shih-Hua Ten, Chia-Yang Su, and Jiunn-Jong Wu Antimicrob. Agents Chemother. April 2001 45: 1281-1283; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Amikacin, Cefepime, Amikacin plus Cefepime, and Imipenem against an SHV-5 Extended-Spectrum -Lactamase-Producing Klebsiella pneumoniae Strain Dóra Szabó, András Máthé, Zsolt Filetóth, Piroska Anderlik, László Rókusz, and Ferenc Rozgonyi Antimicrob. Agents Chemother. April 2001 45: 1287-1291; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Xenograft Model for Identifying Chemotherapeutic Agents against Papillomaviruses A. Pawellek, G. Hewlett, J. Kreuter, H. Rübsamen-Waigmann, and O. Weber Antimicrob. Agents Chemother. April 2001 45: 1014-1021; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacies of Gel Formulations Containing Foscarnet, Alone or Combined with Sodium Lauryl Sulfate, against Establishment and Reactivation of Latent Herpes Simplex Virus Type 1 Jocelyne Piret, Julie Lamontagne, André Désormeaux, and Michel G. Bergeron Antimicrob. Agents Chemother. April 2001 45: 1030-1036; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specific Inhibition of Coxsackievirus B3 Translation and Replication by Phosphorothioate Antisense Oligodeoxynucleotides Aikun Wang, Paul K. M. Cheung, Huifang Zhang, Christopher M. Carthy, Lubos Bohunek, Janet E. Wilson, Bruce M. McManus, and Decheng Yang Antimicrob. Agents Chemother. April 2001 45: 1043-1052; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Activity of -L-2',3'-Dideoxy-2',3'-Didehydro-5-Fluorocytidine in Woodchucks Chronically Infected with Woodchuck Hepatitis Virus F. Le Guerhier, C. Pichoud, C. Jamard, S. Guerret, M. Chevallier, S. Peyrol, O. Hantz, I. King, C. Trépo, Y.-C. Cheng, and F. Zoulim Antimicrob. Agents Chemother. April 2001 45: 1065-1077; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Circulating Metabolites of the Human Immunodeficiency Virus Protease Inhibitor Nelfinavir in Humans: Structural Identification, Levels in Plasma, and Antiviral Activities Kanyin E. Zhang, Ellen Wu, Amy K. Patick, Bradley Kerr, Mark Zorbas, Angela Lankford, Takuo Kobayashi, Yuki Maeda, Bhasker Shetty, and Stephanie Webber Antimicrob. Agents Chemother. April 2001 45: 1086-1093; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir S. Bantia, C. D. Parker, S. L. Ananth, L. L. Horn, K. Andries, P. Chand, P. L. Kotian, A. Dehghani, Y. El-Kattan, T. Lin, T. L. Hutchison, J. A. Montgomery, D. L. Kellog, and Y. S. Babu Antimicrob. Agents Chemother. April 2001 45: 1162-1167; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potentiation of Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Reverse Transcriptases by Combinations of Nonnucleoside Inhibitors and D- and L-()-Dideoxynucleoside Triphosphate Analogs Giovanni Maga, Ulrich Hübscher, Massimo Pregnolato, Daniela Ubiali, Gilles Gosselin, and Silvio Spadari Antimicrob. Agents Chemother. April 2001 45: 1192-1200; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination Treatment with Intralesional Cidofovir and Viral-DNA Vaccination Cures Large Cottontail Rabbit Papillomavirus-Induced Papillomas and Reduces Recurrences Neil D. Christensen, Ricai Han, Nancy M. Cladel, and Martin D. Pickel Antimicrob. Agents Chemother. April 2001 45: 1201-1209; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Zanamivir against Avian Influenza A Viruses That Possess Genes Encoding H5N1 Internal Proteins and Are Pathogenic in Mammals Irina A. Leneva, Olga Goloubeva, Robert J. Fenton, Margaret Tisdale, and Robert G. Webster Antimicrob. Agents Chemother. April 2001 45: 1216-1224; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Human Immunodeficiency Virus Activity of YK-FH312 (a Betulinic Acid Derivative), a Novel Compound Blocking Viral Maturation Taisei Kanamoto, Yoshiki Kashiwada, Kenji Kanbara, Kazuyo Gotoh, Manabu Yoshimori, Toshiyuki Goto, Kouichi Sano, and Hideki Nakashima Antimicrob. Agents Chemother. April 2001 45: 1225-1230; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Activity of Lovastatin against Respiratory Syncytial Virus In Vivo and In Vitro Tara L. Gower and Barney S. Graham Antimicrob. Agents Chemother. April 2001 45: 1231-1237; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Resistance:

---

Rapid Screening Technique for Class 1 Integrons in Enterobacteriaceae and Nonfermenting Gram-Negative Bacteria and Its Use in Molecular Epidemiology Alison J. Maguire, Derek F. J. Brown, James J. Gray, and Ulrich Desselberger Antimicrob. Agents Chemother. April 2001 45: 1022-1029; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

rho Is Not Essential for Viability or Virulence in Staphylococcus aureus Robert S. Washburn, Andrea Marra, Alexander P. Bryant, Martin Rosenberg, and Daniel R. Gentry Antimicrob. Agents Chemother. April 2001 45: 1099-1103; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-Resistant Streptococcus pneumoniae Jeffrey P. Maskell, Armine M. Sefton, and Lucinda M. C. Hall Antimicrob. Agents Chemother. April 2001 45: 1104-1108; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mdt(A), a New Efflux Protein Conferring Multiple Antibiotic Resistance in Lactococcus lactis and Escherichia coli Vincent Perreten, Franziska V. Schwarz, Michael Teuber, and Stuart B. Levy Antimicrob. Agents Chemother. April 2001 45: 1109-1114; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinolone Resistance in Staphylococci: Activities of New Nonfluorinated Quinolones against Molecular Targets in Whole Cells and Clinical Isolates Siddhartha Roychoudhury, Carl E. Catrenich, Eric J. McIntosh, Helana D. McKeever, Kelly M. Makin, Paula M. Koenigs, and Benoit Ledoussal Antimicrob. Agents Chemother. April 2001 45: 1115-1120; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Susceptibility Profiles of Escherichia coli Strains Lacking Multidrug Efflux Pump Genes Mark C. Sulavik, Chad Houseweart, Christina Cramer, Nilofer Jiwani, Nicholas Murgolo, Jonathan Greene, Beth DiDomenico, Karen Joy Shaw, George H. Miller, Roberta Hare, and George Shimer Antimicrob. Agents Chemother. April 2001 45: 1126-1136; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Carbapenem-Hydrolyzing -Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae Hesna Yigit, Anne Marie Queenan, Gregory J. Anderson, Antonio Domenech-Sanchez, James W. Biddle, Christine D. Steward, Sebastian Alberti, Karen Bush, and Fred C. Tenover Antimicrob. Agents Chemother. April 2001 45: 1151-1161; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of ATP-Binding-Cassette Transporter Genes in High-Frequency Acquisition of Resistance to Azole Antifungals in Candida glabrata Dominique Sanglard, Francoise Ischer, and Jacques Bille Antimicrob. Agents Chemother. April 2001 45: 1174-1183; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In70 of Plasmid pAX22, a blaVIM-1-Containing Integron Carrying a New Aminoglycoside Phosphotransferase Gene Cassette Maria Letizia Riccio, Lucia Pallecchi, Roberta Fontana, and Gian Maria Rossolini Antimicrob. Agents Chemother. April 2001 45: 1249-1253; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of the FEZ-1 Metallo--Lactamase of Legionella gormanii ATCC 33297T Produced in Escherichia coli Paola Sandra Mercuri, Fabrice Bouillenne, Letizia Boschi, Josette Lamotte-Brasseur, Gianfranco Amicosante, Bart Devreese, Jozef van Beeumen, Jean-Marie Frère, Gian Maria Rossolini, and Moreno Galleni Antimicrob. Agents Chemother. April 2001 45: 1254-1262; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transposons Tn1696 and Tn21 and Their Integrons In4 and In2 Have Independent Origins Sally R. Partridge, Heidi J. Brown, H. W. Stokes, and Ruth M. Hall Antimicrob. Agents Chemother. April 2001 45: 1263-1270; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Generation of Novel Pyrimethamine Resistance Mutations in the Toxoplasma gondii Dihydrofolate Reductase Mary G. Reynolds, Jung Oh, and David S. Roos Antimicrob. Agents Chemother. April 2001 45: 1271-1277; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New TEM Variant (TEM-92) Produced by Proteus mirabilis and Providencia stuartii Isolates Christophe de Champs, Claire Monne, Richard Bonnet, Wladimir Sougakoff, Danielle Sirot, Catherine Chanal, and Jacques Sirot Antimicrob. Agents Chemother. April 2001 45: 1278-1280; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hypersusceptibility of the Pseudomonas aeruginosa nfxB Mutant to -Lactams Due to Reduced Expression of the AmpC -Lactamase Nobuhisa Masuda, Eiko Sakagawa, Satoshi Ohya, Naomasa Gotoh, and Takeshi Nishino Antimicrob. Agents Chemother. April 2001 45: 1284-1286; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination Effect of Vancomycin and -Lactams against a Staphylococcus aureus Strain, Mu3, with Heterogeneous Resistance to Vancomycin Nanae Aritaka, Hideaki Hanaki, Longzhu Cui, and Keiichi Hiramatsu Antimicrob. Agents Chemother. April 2001 45: 1292-1294; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidrug Resistance Is Mediated by Large Plasmids Carrying a Class 1 Integron in the Emergent Salmonella enterica Serotype [4,5,12:i:] Beatriz Guerra, Sara M. Soto, Jose M. Argüelles, and M. Carmen Mendoza Antimicrob. Agents Chemother. April 2001 45: 1305-1308; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of Tn1546 Elements in Clinical Isolates of Glycopeptide-Resistant Enterococci from Scottish Hospitals A. R. Brown, A. C. Townsley, and S. G. B. Amyes Antimicrob. Agents Chemother. April 2001 45: 1309-1311; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Need for Annual Surveillance of Antimicrobial Resistance in Streptococcus pneumoniae in the United States: 2-Year Longitudinal Analysis Daniel F. Sahm, James A. Karlowsky, Laurie J. Kelly, Ian A. Critchley, Mark E. Jones, Clyde Thornsberry, Yolanda Mauriz, and James Kahn Antimicrob. Agents Chemother. April 2001 45: 1037-1042; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Monitoring of Intracellular ATP Levels in Leishmania donovani Promastigotes as a Rapid Method To Screen Drugs Targeting Bioenergetic Metabolism Juan Román Luque-Ortega, Octavio Miguel Rivero-Lezcano, Simon L. Croft, and Luis Rivas Antimicrob. Agents Chemother. April 2001 45: 1121-1125; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

DNA Transformation of Leishmania infantum Axenic Amastigotes and Their Use in Drug Screening Denis Sereno, Gaétan Roy, Jean Loup Lemesre, Barbara Papadopoulou, and Marc Ouellette Antimicrob. Agents Chemother. April 2001 45: 1168-1173; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent Anti-Trypanosoma cruzi Activities of Oxidosqualene Cyclase Inhibitors Frederick S. Buckner, John H. Griffin, Aaron J. Wilson, and Wesley C. Van Voorhis Antimicrob. Agents Chemother. April 2001 45: 1210-1215; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multicenter Survey of the Changing In Vitro Antimicrobial Susceptibilities of Clinical Isolates of Bacteroides fragilis Group, Prevotella, Fusobacterium, Porphyromonas, and Peptostreptococcus Species Kenneth E. Aldridge, Deborah Ashcraft, Karl Cambre, Carl L. Pierson, Stephen G. Jenkins, and Jon E. Rosenblatt Antimicrob. Agents Chemother. April 2001 45: 1238-1243; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Linezolid against Multiple Nocardia Species Barbara A. Brown-Elliott, Shelby C. Ward, Christopher J. Crist, Linda B. Mann, Rebecca W. Wilson, and Richard J. Wallace, Jr. Antimicrob. Agents Chemother. April 2001 45: 1295-1297; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activities of Milk Lipids R. Corinne Sprong, Marco F. E. Hulstein, and Roelof Van der Meer Antimicrob. Agents Chemother. April 2001 45: 1298-1301; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Peptide Deformylase as an Antibacterial Drug Target: Assays for Detection of Its Inhibition in Escherichia coli Cell Homogenates and Intact Cells Christian M. Apfel, Stefan Evers, Christian Hubschwerlen, Wolfgang Pirson, Malcolm G. P. Page, and Wolfgang Keck Antimicrob. Agents Chemother. April 2001 45: 1053-1057; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development Christian M. Apfel, Hans Locher, Stefan Evers, Béla Takács, Christian Hubschwerlen, Wolfgang Pirson, Malcolm G. P. Page, and Wolfgang Keck Antimicrob. Agents Chemother. April 2001 45: 1058-1064; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of a Novel Antimycobacterial Compound, N-Octanesulfonylacetamide, and Its Effects on Lipid and Mycolic Acid Synthesis Nikki M. Parrish, Todd Houston, Paul B. Jones, Craig Townsend, and James D. Dick Antimicrob. Agents Chemother. April 2001 45: 1143-1150; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

Randomized Prospective Controlled Trial of Recombinant Granulocyte Colony-Stimulating Factor as Adjunctive Therapy for Limb-Threatening Diabetic Foot Infection Fausto de Lalla, Giampietro Pellizzer, Marco Strazzabosco, Zeno Martini, Giovanni Du Jardin, Luciano Lora, Paolo Fabris, Paolo Benedetti, and Giuseppe Erle Antimicrob. Agents Chemother. April 2001 45: 1094-1098; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Isoniazid-Induced Expression of Mycobacterium tuberculosis Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials Robert S. Wallis, Manijeh Phillips, John L. Johnson, Luciléia Teixeira, Lia Márcia Massini Canedo Rocha, Ethel Maciel, Lynn Rose, Charles Wells, Moisés Palaci, Reynaldo Dietze, Kathleen Eisenach, and Jerrold J. Ellner Antimicrob. Agents Chemother. April 2001 45: 1302-1304; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Biologic Response Modifiers:

---

Identification of Genes Induced by a Macrophage Activator, S-28463, Using Gene Expression Array Analysis Sureemas Buates and Greg Matlashewski Antimicrob. Agents Chemother. April 2001 45: 1137-1142; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Blocking the Receptor for Interleukin 10 Protects Mice from Lethal Listeriosis Regina A. Silva and Rui Appelberg Antimicrob. Agents Chemother. April 2001 45: 1312-1314; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Amphotericin B Lipid Complex or Amphotericin B Multiple-Dose Administration to Rabbits with Elevated Plasma Cholesterol Levels: Pharmacokinetics in Plasma and Blood, Plasma Lipoprotein Levels, Distribution in Tissues, and Renal Toxicities Manisha Ramaswamy, Kathy D. Peteherych, Allison L. Kennedy, and Kishor M. Wasan Antimicrob. Agents Chemother. April 2001 45: 1184-1191; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Recent Approvals:

---

Antimicrob. Agents Chemother. April 2001 45: 1315 [Full Text] [PDF] [Reprints and Permissions]

---

Errata:

---

Letter to the Editor: Macrolide Resistance in Campylobacter coli of Animal Origin in Denmark Lars Bogø Jensen and Frank M. Aarestrup Antimicrob. Agents Chemother. April 2001 45: 1316 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.