Contents: May 2001, Volume 45, Issue 5        Mechanisms of Action        Mechanisms of Resistance        Susceptibility        Chemistry; Biosynthesis        Pharmacology        Experimental Therapeutics        Antiviral Agents        Biologic Response Modifiers        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Action:

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Screening System for Xenosiderophores as Potential Drug Delivery Agents in Mycobacteria Gisbert Schumann and Ute Möllmann Antimicrob. Agents Chemother. May 2001 45: 1317-1322; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergy of Histone-Derived Peptides of Coho Salmon with Lysozyme and Flounder Pleurocidin Aleksander Patrzykat, Lijuan Zhang, Valentina Mendoza, George K. Iwama, and Robert E. W. Hancock Antimicrob. Agents Chemother. May 2001 45: 1337-1342; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antileishmanial Activity of an Indole Alkaloid from Peschiera australis Jan Carlo Delorenzi, Márcia Attias, Cerli R. Gattass, Marcelo Andrade, Cláudia Rezende, Ângelo da Cunha Pinto, Amélia T. Henriques, Dumith C. Bou-Habib, and Elvira M. B. Saraiva Antimicrob. Agents Chemother. May 2001 45: 1349-1354; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Genetics of dTDP-Rhamnose Synthetic Enzymes and Development of a Microtiter Plate-Based Screen for Inhibitors of Conversion of dTDP-Glucose to dTDP-Rhamnose Yufang Ma, Richard J. Stern, Michael S. Scherman, Varalakshmi D. Vissa, Wenxin Yan, Victoria Cox Jones, Fangqiu Zhang, Scott G. Franzblau, Walter H. Lewis, and Michael R. McNeil Antimicrob. Agents Chemother. May 2001 45: 1407-1416; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities and Conformational Fitting of 1,4-Naphthoquinone Derivatives and Other Cyclic 1,4-Diones Tested In Vitro against Pneumocystis carinii M. D. Ball, M. S. Bartlett, M. Shaw, J. W. Smith, M. Nasr, and S. R. Meshnick Antimicrob. Agents Chemother. May 2001 45: 1473-1479; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Activities of Lansoprazole against Respiration in Helicobacter pylori Kumiko Nagata, Nobuhito Sone, and Toshihide Tamura Antimicrob. Agents Chemother. May 2001 45: 1522-1527; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Potassium on Saccharomyces cerevisiae Resistance to Fluconazole Carlos A. Stella and Hilda I. Burgos Antimicrob. Agents Chemother. May 2001 45: 1589-1590; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Structural Comparison of Three Types of Staphylococcal Cassette Chromosome mec Integrated in the Chromosome in Methicillin-Resistant Staphylococcus aureus Teruyo Ito, Yuki Katayama, Kazumi Asada, Namiko Mori, Kanae Tsutsumimoto, Chuntima Tiensasitorn, and Keiichi Hiramatsu Antimicrob. Agents Chemother. May 2001 45: 1323-1336; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Encoded Metallo--Lactamase (IMP-6) Conferring Resistance to Carbapenems, Especially Meropenem Hisakazu Yano, Akio Kuga, Ryoichi Okamoto, Hidero Kitasato, Toshimitsu Kobayashi, and Matsuhisa Inoue Antimicrob. Agents Chemother. May 2001 45: 1343-1348; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differences in Antibiotic Resistance Patterns of Enterococcus faecalis and Enterococcus faecium Strains Isolated from Farm and Pet Animals Patrick Butaye, Luc A. Devriese, and Freddy Haesebrouck Antimicrob. Agents Chemother. May 2001 45: 1374-1378; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhanced Expression of the Multidrug Efflux Pumps AcrAB and AcrEF Associated with Insertion Element Transposition in Escherichia coli Mutants Selected with a Fluoroquinolone A. S. Jellen-Ritter and W. V. Kern Antimicrob. Agents Chemother. May 2001 45: 1467-1472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penicillin-Binding Protein 5 and Expression of Ampicillin Resistance in Enterococcus faecium Louis B. Rice, Lenore L. Carias, Rebecca Hutton-Thomas, Farid Sifaoui, Laurent Gutmann, and Susan D. Rudin Antimicrob. Agents Chemother. May 2001 45: 1480-1486; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Accurate Prediction of Macrolide Resistance in Helicobacter pylori by a PCR Line Probe Assay for Detection of Mutations in the 23S rRNA Gene: Multicenter Validation Study Leen-Jan van Doorn, Youri Glupczynski, Johannes G. Kusters, Francis Mégraud, Peter Midolo, Nadia Maggi-Solcà, Dulciene M. M. Queiroz, Nathalie Nouhan, Els Stet, and Wim G. V. Quint Antimicrob. Agents Chemother. May 2001 45: 1500-1504; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical Escherichia coli Strains from China: Role of acrR Mutations Hui Wang, Joann L. Dzink-Fox, Minjun Chen, and Stuart B. Levy Antimicrob. Agents Chemother. May 2001 45: 1515-1521; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance and Adaptation to Quinidine in Saccharomyces cerevisiae: Role of QDR1 (YIL120w), Encoding a Plasma Membrane Transporter of the Major Facilitator Superfamily Required for Multidrug Resistance Patrícia A. Nunes, Sandra Tenreiro, and Isabel Sá-Correia Antimicrob. Agents Chemother. May 2001 45: 1528-1534; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Absence of Mutations in marRAB or soxRS in acrB-Overexpressing Fluoroquinolone-Resistant Clinical and Veterinary Isolates of Escherichia coli Mark A. Webber and Laura J. V. Piddock Antimicrob. Agents Chemother. May 2001 45: 1550-1552; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Six Quinolones and Mechanisms of Resistance in Staphylococcus aureus and Coagulase-Negative Staphylococci Hans-Jörg Linde, Mario Schmidt, Emmi Fuchs, Udo Reischl, Hans-Helmut Niller, and Norbert Lehn Antimicrob. Agents Chemother. May 2001 45: 1553-1557; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Macrolide Resistance in Streptococcus pneumoniae in Hong Kong Margaret Ip, Donald J. Lyon, Raymond W. H. Yung, Colin Chan, and Augustine F. B. Cheng Antimicrob. Agents Chemother. May 2001 45: 1578-1580; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa Lesley McGee, Keith P. Klugman, Avril Wasas, Thora Capper, Adrian Brink, and The Antibiotics Surveillance Forum Of South Africa Antimicrob. Agents Chemother. May 2001 45: 1595-1598; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Interactions of Posaconazole and Flucytosine against Cryptococcus neoformans Francesco Barchiesi, Anna Maria Schimizzi, Laura K. Najvar, Rosie Bocanegra, Francesca Caselli, Simona Di Cesare, Daniele Giannini, Luigi Falconi Di Francesco, Andrea Giacometti, Flavia Carle, Giorgio Scalise, and John R. Graybill Antimicrob. Agents Chemother. May 2001 45: 1355-1359; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Aminoadamantane and Aminoalkylcyclohexane Derivatives against Trypanosoma brucei John M. Kelly, Guenter Quack, and Michael M. Miles Antimicrob. Agents Chemother. May 2001 45: 1360-1366; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidrug-Resistant Urinary Tract Isolates of Escherichia coli: Prevalence and Patient Demographics in the United States in 2000 Daniel F. Sahm, Clyde Thornsberry, David C. Mayfield, Mark E. Jones, and James A. Karlowsky Antimicrob. Agents Chemother. May 2001 45: 1402-1406; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Bismuth Thiols against Staphylococci and Staphylococcal Biofilms Philip Domenico, Lucilla Baldassarri, Paul E. Schoch, Kristina Kaehler, Masanori Sasatsu, and Burke A. Cunha Antimicrob. Agents Chemother. May 2001 45: 1417-1421; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of RWJ-54428 (MC-02,479) against Multiresistant Gram-Positive Bacteria Suzanne Chamberland, Johanne Blais, Monica Hoang, Cynthia Dinh, Dylan Cotter, Emmett Bond, Carla Gannon, Craig Park, Francois Malouin, and Michael N. Dudley Antimicrob. Agents Chemother. May 2001 45: 1422-1430; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Intramacrophage Growth of Penicillium marneffei by 4-Aminoquinolines Donatella Taramelli, Clara Tognazioli, F. Ravagnani, O. Leopardi, G. Giannulis, and J. R. Boelaert Antimicrob. Agents Chemother. May 2001 45: 1450-1455; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility Testing of Aspergillus flavus: Inoculum Dependence with Itraconazole and Lack of Correlation between Susceptibility to Amphotericin B In Vitro and Outcome In Vivo J. Mosquera, P. A. Warn, J. Morrissey, C. B. Moore, C. Gil-Lamaignere, and D. W. Denning Antimicrob. Agents Chemother. May 2001 45: 1456-1462; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of BMS 284756 (T-3811) against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae Isolates from SENTRY Antimicrobial Surveillance Program Medical Centers in Latin America (1999) Ana Gales, Helio Sader, and Ronald N. Jones Antimicrob. Agents Chemother. May 2001 45: 1463-1466; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Miltefosine and Other Alkylphosphocholines on Human Intestinal Parasite Entamoeba histolytica Karin Seifert, Michael Duchêne, Walther H. Wernsdorfer, Herwig Kollaritsch, Otto Scheiner, Gerhard Wiedermann, Thomas Hottkowitz, and Hansjörg Eibl Antimicrob. Agents Chemother. May 2001 45: 1505-1510; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Susceptibilities of Genetically Characterized Streptococcus milleri Group Strains Michael Tracy, Anna Wanahita, Yevgeny Shuhatovich, Elizabeth A. Goldsmith, Jill E. Clarridge, III, and Daniel M. Musher Antimicrob. Agents Chemother. May 2001 45: 1511-1514; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Interactions between Mammalian Antimicrobial Defense Peptides Hong Yan and Robert E. W. Hancock Antimicrob. Agents Chemother. May 2001 45: 1558-1560; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Clarithromycin against Intracellular Helicobacter pylori Raffaele Piccolomini, Giovanni Di Bonaventura, Carla Picciani, Francesco Laterza, Jacopo Vecchiet, and Matteo Neri Antimicrob. Agents Chemother. May 2001 45: 1568-1571; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibilities of Unique Stenotrophomonas maltophilia Clinical Strains Sylvia Valdezate, Ana Vindel, Elena Loza, Fernando Baquero, and Rafael Cantón Antimicrob. Agents Chemother. May 2001 45: 1581-1584; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of -Lactamase-Negative, Ampicillin-Resistant Strains of Haemophilus influenzae with Four Methods and Eight Media Arthur L. Barry, Peter C. Fuchs, and Steven D. Brown Antimicrob. Agents Chemother. May 2001 45: 1585-1588; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Anticandida Activity Is Retained in P-113, a 12-Amino-Acid Fragment of Histatin 5 David M. Rothstein, Peter Spacciapoli, Linh T. Tran, Tao Xu, F. Donald Roberts, Mauro Dalla Serra, Deborah K. Buxton, Frank G. Oppenheim, and Phillip Friden Antimicrob. Agents Chemother. May 2001 45: 1367-1373; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects Terri Creagh, Jon L. Ruckle, Dwain T. Tolbert, Jeremy Giltner, David A. Eiznhamer, Bipul Dutta, Michael T. Flavin, and Ze-Qi Xu Antimicrob. Agents Chemother. May 2001 45: 1379-1386; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Itraconazole Oral Solution in Neutropenic Children during Long-Term Prophylaxis Claudine Schmitt, Yves Perel, Jean-luc Harousseau, Sophie Lemerle, Elisabeth Chwetzoff, Jean-Pierre le Moing, and Jean-Claude Levron Antimicrob. Agents Chemother. May 2001 45: 1561-1564; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Vancomycin and Ceftazidime Bioactivities Persist for at Least 2 Weeks in the Lumen in Ports: Simplifying Treatment of Port-Associated Bloodstream Infections by Using the Antibiotic Lock Technique Yishai Haimi-Cohen, Neghma Husain, Jerry Meenan, Gungor Karayalcin, Michael Lehrer, and Lorry G. Rubin Antimicrob. Agents Chemother. May 2001 45: 1565-1567; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tolerance and Pharmacokinetic Interactions of Rifabutin and Azithromycin Richard Hafner, James Bethel, Harold C. Standiford, Stephen Follansbee, David L. Cohn, Ronald E. Polk, Larry Mole, Ralph Raasch, Princy Kumar, David Mushatt, and George Drusano Antimicrob. Agents Chemother. May 2001 45: 1572-1577; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Efficacy of Teicoplanin-Gentamicin Given Once a Day on the Basis of Pharmacokinetics in Humans for Treatment of Enterococcal Experimental Endocarditis Pedro López, Joan Gavaldà, M. Teresa Martin, Benito Almirante, Xavier Gomis, Carlos Azuaje, Nuria Borrell, Leonor Pou, Vicenç Falcó, Carles Pigrau, and Albert Pahissa Antimicrob. Agents Chemother. May 2001 45: 1387-1393; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy of Trovafloxacin against Bacteroides fragilis in Mixed Infection with either Escherichia coli or a Vancomycin-Resistant Strain of Enterococcus faecium in an Established-Abscess Murine Model Lorna E. T. Stearne, Inge C. Gyssens, Wil H. F. Goessens, Johan W. Mouton, Wim J. G. Oyen, Jos W. M. van der Meer, and Henri A. Verbrugh Antimicrob. Agents Chemother. May 2001 45: 1394-1401; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism and Suppression of Lysostaphin Resistance in Oxacillin-Resistant Staphylococcus aureus Michael W. Climo, Kerstin Ehlert, and Gordon L. Archer Antimicrob. Agents Chemother. May 2001 45: 1431-1437; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Improved Efficacy of Ciprofloxacin Administered in Polyethylene Glycol-Coated Liposomes for Treatment of Klebsiella pneumoniae Pneumonia in Rats Irma A. J. M. Bakker-Woudenberg, Marian T. ten Kate, Luke Guo, Peter Working, and Johan W. Mouton Antimicrob. Agents Chemother. May 2001 45: 1487-1492; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antifungal Activity of KP-103, a Novel Triazole Derivative, and Its Therapeutic Efficacy against Experimental Plantar Tinea Pedis and Cutaneous Candidiasis in Guinea Pigs Yoshiyuki Tatsumi, Mamoru Yokoo, Tadashi Arika, and Hideyo Yamaguchi Antimicrob. Agents Chemother. May 2001 45: 1493-1499; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prolonged Antimicrobial Activity of a Catheter Containing Chlorhexidine-Silver Sulfadiazine Extends Protection against Catheter Infections In Vivo Stefano Bassetti, Jean Hu, Ralph B. D'Agostino, Jr., and Robert J. Sherertz Antimicrob. Agents Chemother. May 2001 45: 1535-1538; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Short-Term Measures of Relative Efficacy Predict Longer-Term Reductions in Human Immunodeficiency Virus Type 1 RNA Levels following Nelfinavir Monotherapy John Mittler, Paulina Essunger, Geoffrey J. Yuen, Neil Clendeninn, Martin Markowitz, and Alan S. Perelson Antimicrob. Agents Chemother. May 2001 45: 1438-1443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ganciclovir and Cidofovir Treatment of Cytomegalovirus-Induced Myocarditis in Mice Jason C. Lenzo, Geoffrey R. Shellam, and Cassandra M. Lawson Antimicrob. Agents Chemother. May 2001 45: 1444-1449; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

4'-Ethynyl Nucleoside Analogs: Potent Inhibitors of Multidrug-Resistant Human Immunodeficiency Virus Variants In Vitro Ei-Ichi Kodama, Satoru Kohgo, Kenji Kitano, Haruhiko Machida, Hiroyuki Gatanaga, Shiro Shigeta, Masao Matsuoka, Hiroshi Ohrui, and Hiroaki Mitsuya Antimicrob. Agents Chemother. May 2001 45: 1539-1546; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Thalidomide Inhibits Granulocyte Responses in Healthy Humans after Ex Vivo Stimulation with Bacterial Antigens Nicole P. Juffermans, Annelies Verbon, Marc J. Schultz, C. Erik Hack, Sander J. H. van Deventer, Peter Speelman, and Tom van der Poll Antimicrob. Agents Chemother. May 2001 45: 1547-1549; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevention and Treatment of Lethal Murine Endotoxemia by the Novel Immunomodulatory Agent MFP-14 Ferdinando Nicoletti, Roberto Di Marco, Paola Sacerdote, PierLuigi Meroni, Katia Mangano, Carl Edwards, III, Alberto Bartorelli, Klaus Bendtzen, and Alberto Panerai Antimicrob. Agents Chemother. May 2001 45: 1591-1594; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Use of Mutator Strains for Characterization of Novel Antimicrobial Agents Alexander John O'Neill, Ian Chopra, José L. Martínez, and Fernando Baquero Antimicrob. Agents Chemother. May 2001 45: 1599-1600; [Full Text] [PDF] [Reprints and Permissions]

Is OmpK35 Specific for Ceftazadime Penetration? L. K. Siu, J. Kamile Rasheed, Luis Martínez-Martínez, and George A. Jacoby Antimicrob. Agents Chemother. May 2001 45: 1601-1602; [Full Text] [PDF] [Reprints and Permissions]

Structural Alterations in the Translational Attenuator of Constitutively Expressed erm(A) Genes in Staphylococcus aureus Franz-Josef Schmitz, Jasmina Petridou, Nadine Astfalk, Sibylle Scheuring, Karl Köhrer, Jan Verhoef, Ad C. Fluit, and Stefan Schwarz Antimicrob. Agents Chemother. May 2001 45: 1603-1604; [Full Text] [PDF] [Reprints and Permissions]

Emergence of Fluoroquinolone-Resistant Strains of Vibrio cholerae O1 Biotype El Tor among Hospitalized Patients with Cholera in Calcutta, India Pallavi Garg, Sutapa Sinha, Rupa Chakraborty, S. K. Bhattacharya, G. Balakrish Nair, T. Ramamurthy, and Yoshifumi Takeda Antimicrob. Agents Chemother. May 2001 45: 1605-1606; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.