Contents: September 2001, Volume 45, Issue 9        Mechanisms of Resistance        Experimental Therapeutics        Susceptibility        Mechanisms of Action        Clinical Therapeutics        Antiviral Agents        Pharmacology        Biologic Response Modifiers        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Resistance:

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Diversity of SHV and TEM -Lactamases in Klebsiella pneumoniae: Gene Evolution in Northern Taiwan and Two Novel -Lactamases, SHV-25 and SHV-26 Feng-Yee Chang, L. K. Siu, Chang-Phone Fung, Min-Hua Huang, and Monto Ho Antimicrob. Agents Chemother. September 2001 45: 2407-2413; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aminoglycoside Resistance with Homogeneous and Heterogeneous Populations of Antibiotic-Resistant Ribosomes Michael I. Recht and Joseph D. Puglisi Antimicrob. Agents Chemother. September 2001 45: 2414-2419; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance of Streptococcus pneumoniae to Deformylase Inhibitors Is Due to Mutations in defB Peter Margolis, Corinne Hackbarth, Sara Lopez, Mita Maniar, Wen Wang, Zhengyu Yuan, Richard White, and Joaquim Trias Antimicrob. Agents Chemother. September 2001 45: 2432-2435; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alkyl-Lysophospholipid Resistance in Multidrug-Resistant Leishmania tropica and Chemosensitization by a Novel P-Glycoprotein-Like Transporter Modulator José M. Pérez-Victoria, F. Javier Pérez-Victoria, Adriana Parodi-Talice, Ignacio A. Jiménez, Angel G. Ravelo, Santiago Castanys, and Francisco Gamarro Antimicrob. Agents Chemother. September 2001 45: 2468-2474; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

SHV-16, a -Lactamase with a Pentapeptide Duplication in the Omega Loop Corinne Arpin, Roger Labia, Catherine Andre, Cécile Frigo, Zoubida El Harrif, and Claudine Quentin Antimicrob. Agents Chemother. September 2001 45: 2480-2485; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Expression of Ubiquitin Gene in Microsporum canis and Trichophyton mentagrophytes Cultured with Fluconazole Rui Kano, Ken Okabayashi, Yuka Nakamura, Shinichi Watanabe, and Atsuhiko Hasegawa Antimicrob. Agents Chemother. September 2001 45: 2559-2562; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Penicillin-Binding Protein 5 in Expression of Ampicillin Resistance and Peptidoglycan Structure in Enterococcus faecium Farid Sifaoui, Michel Arthur, Louis Rice, and Laurent Gutmann Antimicrob. Agents Chemother. September 2001 45: 2594-2597; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

GES-2, a Class A -Lactamase from Pseudomonas aeruginosa with Increased Hydrolysis of Imipenem Laurent Poirel, Gerhard F. Weldhagen, Thierry Naas, Christophe De Champs, Michael G. Dove, and Patrice Nordmann Antimicrob. Agents Chemother. September 2001 45: 2598-2603; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

DNA Sequence Analysis of rdxA and frxA from 12 Pairs of Metronidazole-Sensitive and -Resistant Clinical Helicobacter pylori Isolates D. H. Kwon, K. Hulten, M. Kato, J. J. Kim, M. Lee, F. A. K. El-Zaatari, M. S. Osato, and D. Y. Graham Antimicrob. Agents Chemother. September 2001 45: 2609-2615; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Risk Factors for Emergence of Resistance to Broad-Spectrum Cephalosporins among Enterobacter spp. Keith S. Kaye, Sara Cosgrove, Anthony Harris, George M. Eliopoulos, and Yehuda Carmeli Antimicrob. Agents Chemother. September 2001 45: 2628-2630; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae Darrin J. Bast, Joyce C. S. de Azavedo, Tiffany Y. Tam, Laurie Kilburn, Carla Duncan, Lionel A. Mandell, Ross J. Davidson, and Donald E. Low Antimicrob. Agents Chemother. September 2001 45: 2631-2634; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of a Pneumococcal Clone with Cephalosporin Resistance and Penicillin Susceptibility Anthony M. Smith, Roelof F. Botha, Hendrik J. Koornhof, and Keith P. Klugman Antimicrob. Agents Chemother. September 2001 45: 2648-2650; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidrug-Resistant Strains of Neisseria gonorrhoeae in Greece Angeliki Mavroidi, Leonidas S. Tzouvelekis, Kyriakos P. Kyriakis, Helen Avgerinou, Maria Daniilidou, and Eva Tzelepi Antimicrob. Agents Chemother. September 2001 45: 2651-2654; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integrons and Gene Cassettes in the Enterobacteriaceae Peter A. White, Christopher J. McIver, and William D. Rawlinson Antimicrob. Agents Chemother. September 2001 45: 2658-2661; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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In Vitro and In Vivo Activities of Syn2836, Syn2869, Syn2903, and Syn2921: New Series of Triazole Antifungal Agents S. M. Salama, H. Atwal, A. Gandhi, J. Simon, M. Poglod, H. Montaseri, J. K. Khan, T. Furukawa, H. Saito, K. Nishida, F. Higashitani, T. Uji, N. Unemi, M. Daneshtalab, and R. G. Micetich Antimicrob. Agents Chemother. September 2001 45: 2420-2426; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic and Pharmacodynamic Parameters for Antimicrobial Effects of Cefotaxime and Amoxicillin in an In Vitro Kinetic Model I. Gustafsson, E. Löwdin, I. Odenholt, and O. Cars Antimicrob. Agents Chemother. September 2001 45: 2436-2440; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Therapeutic Effectiveness of Cefixime against Typhoid Fever Yoshimi Matsumoto, Akiko Ikemoto, Yoshimi Wakai, Fumiaki Ikeda, Shuichi Tawara, and Keizo Matsumoto Antimicrob. Agents Chemother. September 2001 45: 2450-2454; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antibacterial Activities of TAK-083, an Agent for Treatment of Helicobacter pylori Infection Tsuneo Kanamaru, Yoshitaka Nakano, Yukio Toyoda, Ken-Ichiro Miyagawa, Mayumi Tada, Tomoko Kaisho, and Masafumi Nakao Antimicrob. Agents Chemother. September 2001 45: 2455-2459; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacies of ABT-773, a New Ketolide, against Experimental Bacterial Infections M. J. Mitten, J. Meulbroek, M. Nukkala, L. Paige, K. Jarvis, A. Oleksijew, A. Tovcimak, L. Hernandez, J. D. Alder, P. Ewing, Y. S. Or, Z. Ma, A. M. Nilius, K. Mollison, and R. K. Flamm Antimicrob. Agents Chemother. September 2001 45: 2585-2593; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Treatment of Visceral Leishmaniasis with Sterically Stabilized Liposomes Containing Camptothecin Marie-Eve Proulx, André Désormeaux, Jean-François Marquis, Martin Olivier, and Michel G. Bergeron Antimicrob. Agents Chemother. September 2001 45: 2623-2627; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Activity of Telithromycin against Spanish Streptococcus pneumoniae Isolates with Characterized Macrolide Resistance Mechanisms María-Isabel Morosini, Rafael Cantón, Elena Loza, María-Cristina Negri, Juan-Carlos Galán, Felisa Almaraz, and Fernando Baquero Antimicrob. Agents Chemother. September 2001 45: 2427-2431; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Standardized Method for In Vitro Antifungal Susceptibility Testing of Candida albicans Biofilms Gordon Ramage, Kacy Vande Walle, Brian L. Wickes, and José L. López-Ribot Antimicrob. Agents Chemother. September 2001 45: 2475-2479; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Fluoroquinolones against the Spirochete Borrelia burgdorferi Peter Kraiczy, Judith Weigand, Thomas A. Wichelhaus, Peter Heisig, Herbert Backes, Volker Schäfer, Georg Acker, Volker Brade, and Klaus-Peter Hunfeld Antimicrob. Agents Chemother. September 2001 45: 2486-2494; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of 10 Antifungal Drugs against 508 Dermatophyte Strains B. Fernández-Torres, A. J. Carrillo, E. Martín, A. Del Palacio, M. K. Moore, A. Valverde, M. Serrano, and J. Guarro Antimicrob. Agents Chemother. September 2001 45: 2524-2528; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, Dalfopristin, Dirithromycin, Evernimicin, Gatifloxacin, Linezolid, Moxifloxacin, Quinupristin-Dalfopristin, and Telithromycin Compared to Their Susceptibilities to Reference Macrolides, Tetracyclines, and Quinolones George E. Kenny and Frank D. Cartwright Antimicrob. Agents Chemother. September 2001 45: 2604-2608; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antifungal Activities of the New Triazole UR-9825 against Clinically Important Filamentous Fungi Javier Capilla, Montserrat Ortoneda, Francisco Javier Pastor, and Josep Guarro Antimicrob. Agents Chemother. September 2001 45: 2635-2637; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions of Quinupristin-Dalfopristin with Eight Other Antibiotics as Measured by Time-Kill Studies with 10 Strains of Staphylococcus aureus for Which Quinupristin-Dalfopristin Alone Was Not Bactericidal Peter C. Fuchs, Arthur L. Barry, and Steven D. Brown Antimicrob. Agents Chemother. September 2001 45: 2662-2665; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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N-Terminal Fatty Acid Substitution Increases the Leishmanicidal Activity of CA(1-7)M(2-9), a Cecropin-Melittin Hybrid Peptide Cristina Chicharro, Cesare Granata, Rosario Lozano, David Andreu, and Luis Rivas Antimicrob. Agents Chemother. September 2001 45: 2441-2449; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isolation of Rat Dihydrofolate Reductase Gene and Characterization of Recombinant Enzyme Yangzhou Wang, Jeremy A. Bruenn, Sherry F. Queener, and Vivian Cody Antimicrob. Agents Chemother. September 2001 45: 2517-2523; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Limonene Arrests Parasite Development and Inhibits Isoprenylation of Proteins in Plasmodium falciparum Ivan Cruz Moura, Gerhard Wunderlich, Maria L. Uhrig, Alicia S. Couto, Valnice J. Peres, Alejandro M. Katzin, and Emília A. Kimura Antimicrob. Agents Chemother. September 2001 45: 2553-2558; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Virtual Screening of Combinatorial Libraries across a Gene Family: in Search of Inhibitors of Giardia lamblia Guanine Phosphoribosyltransferase Alex M. Aronov, Narsimha R. Munagala, Irwin D. Kuntz, and Ching C. Wang Antimicrob. Agents Chemother. September 2001 45: 2571-2576; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Class of Small Nonpeptidyl Compounds Blocks Plasmodium falciparum Development In Vitro by Inhibiting Plasmepsins Suping Jiang, Sean T. Prigge, Lan Wei, Yu-e Gao, Thomas H. Hudson, Lucia Gerena, John B. Dame, and Dennis E. Kyle Antimicrob. Agents Chemother. September 2001 45: 2577-2584; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structural Analysis of Chloroquine Resistance Reversal by Imipramine Analogs Apurba K. Bhattacharjee, Dennis E. Kyle, and Jonathan L. Vennerstrom Antimicrob. Agents Chemother. September 2001 45: 2655-2657; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Continuous versus Intermittent Infusion of Vancomycin in Severe Staphylococcal Infections: Prospective Multicenter Randomized Study Marc Wysocki, Frederique Delatour, François Faurisson, Alain Rauss, Yves Pean, Benoit Misset, Frank Thomas, Jean-François Timsit, Thomas Similowski, Herve Mentec, Laurence Mier, and Didier Dreyfuss Antimicrob. Agents Chemother. September 2001 45: 2460-2467; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Occurrence and Risk of Cochleotoxicity in Cystic Fibrosis Patients Receiving Repeated High-Dose Aminoglycoside Therapy M. Mulheran, C. Degg, S. Burr, D. W. Morgan, and D. E. Stableforth Antimicrob. Agents Chemother. September 2001 45: 2502-2509; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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In Vitro Susceptibilities of Wild-Type or Drug-Resistant Hepatitis B Virus to ()--D-2,6-Diaminopurine Dioxolane and 2'-Fluoro-5-Methyl--L-Arabinofuranosyluracil Ruth Chin, Tim Shaw, Joseph Torresi, Vittina Sozzi, Christian Trautwein, Thomas Bock, Michael Manns, Harriet Isom, Phil Furman, and Stephen Locarnini Antimicrob. Agents Chemother. September 2001 45: 2495-2501; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specific Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Integration in Cell Culture: Putative Inhibitors of HIV-1 Integrase Nick Vandegraaff, Raman Kumar, Helen Hocking, Terrence R. Burke, Jr., John Mills, David Rhodes, Christopher J. Burrell, and Peng Li Antimicrob. Agents Chemother. September 2001 45: 2510-2516; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel - and -Amino Acid Inhibitors of Influenza Virus Neuraminidase Warren M. Kati, Debra Montgomery, Clarence Maring, Vincent S. Stoll, Vincent Giranda, Xiaoqi Chen, W. Graeme Laver, William Kohlbrenner, and Daniel W. Norbeck Antimicrob. Agents Chemother. September 2001 45: 2563-2570; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cell-Based Fluorescence Assay for Human Immunodeficiency Virus Type 1 Protease Activity Kristina Lindsten, Tat'ána Uhlíková, Jan Konvalinka, Maria G. Masucci, and Nico P. Dantuma Antimicrob. Agents Chemother. September 2001 45: 2616-2622; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacokinetics of Clinafloxacin after Single and Multiple Doses Edward J. Randinitis, Joanne I. Brodfuehrer, Irene Eiseman, and Artemios B. Vassos Antimicrob. Agents Chemother. September 2001 45: 2529-2535; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinafloxacin Pharmacokinetics in Subjects with Various Degrees of Renal Function Edward J. Randinitis, Jeffery R. Koup, George Rausch, Robert Abel, Nicola J. Bron, Neil J. Hounslow, Artemios B. Vassos, and Allen J. Sedman Antimicrob. Agents Chemother. September 2001 45: 2536-2542; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drug Interactions with Clinafloxacin Edward J. Randinitis, Christine W. Alvey, Jeffery R. Koup, George Rausch, Robert Abel, Nicola J. Bron, Neil J. Hounslow, Artemios B. Vassos, and Allen J. Sedman Antimicrob. Agents Chemother. September 2001 45: 2543-2552; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Stability and Compatibility of Ceftazidime Administered by Continuous Infusion to Intensive Care Patients Hélène Servais and Paul M. Tulkens Antimicrob. Agents Chemother. September 2001 45: 2643-2647; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Pretreatment of Mice with Clindamycin Improves Survival of Endotoxic Shock by Modulating the Release of Inflammatory Cytokines Norio Hirata, Kazufumi Hiramatsu, Kenji Kishi, Tohru Yamasaki, Tomoku Ichimiya, and Masaru Nasu Antimicrob. Agents Chemother. September 2001 45: 2638-2642; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Propensity of Fluoroquinolones with Different Moieties at Position 8 to Cause Resistance Development in Clinical Isolates of Streptococcus pneumoniae F.-J. Schmitz, Mechthild Boos, Susanne Mayer, Dieter Hafner, Harold Jagusch, Jan Verhoef, and Ad C. Fluit Antimicrob. Agents Chemother. September 2001 45: 2666-2667; [Full Text] [PDF] [Reprints and Permissions]

Effects of Moxifloxacin on Neutrophil Phagocytosis, Burst Production, and Killing as Determined by a Whole-Blood Cytofluorometric Method Stefan Fischer and Dieter Adam Antimicrob. Agents Chemother. September 2001 45: 2668-2669; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.