Contents: October 2002, Volume 46, Issue 10        Mechanisms of Action        Mechanisms of Resistance        Susceptibility        Experimental Therapeutics        Antiviral Agents        Clinical Therapeutics        Pharmacology        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Action:

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Endogenous Reactive Oxygen Species Is an Important Mediator of Miconazole Antifungal Effect Daisuke Kobayashi, Kei Kondo, Nobuyuki Uehara, Seiko Otokozawa, Naoki Tsuji, Atsuhito Yagihashi, and Naoki Watanabe Antimicrob. Agents Chemother. October 2002 46: 3113-3117; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents David J. Payne, William H. Miller, Valerie Berry, John Brosky, Walter J. Burgess, Emile Chen, Walter E. DeWolf, Jr., Andrew P. Fosberry, Rebecca Greenwood, Martha S. Head, Dirk A. Heerding, Cheryl A. Janson, Deborah D. Jaworski, Paul M. Keller, Peter J. Manley, Terrance D. Moore, Kenneth A. Newlander, Stewart Pearson, Brian J. Polizzi, Xiayang Qiu, Stephen F. Rittenhouse, Courtney Slater-Radosti, Kevin L. Salyers, Mark A. Seefeld, Martin G. Smyth, Dennis T. Takata, Irene N. Uzinskas, Kalindi Vaidya, Nicola G. Wallis, Scott B. Winram, Catherine C. K. Yuan, and William F. Huffman Antimicrob. Agents Chemother. October 2002 46: 3118-3124; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Properties of Milk: Dependence on Presence of Xanthine Oxidase and Nitrite John T. Hancock, Vyv Salisbury, Maria Cristina Ovejero-Boglione, Robert Cherry, Catherine Hoare, Robert Eisenthal, and Roger Harrison Antimicrob. Agents Chemother. October 2002 46: 3308-3310; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Biochemical and Genetic Characterization of the vanC-2 Vancomycin Resistance Gene Cluster of Enterococcus casseliflavus ATCC 25788 Ireena Dutta and Peter E. Reynolds Antimicrob. Agents Chemother. October 2002 46: 3125-3132; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidrug Pump Inhibitors Uncover Remarkable Activity of Plant Antimicrobials George Tegos, Frank R. Stermitz, Olga Lomovskaya, and Kim Lewis Antimicrob. Agents Chemother. October 2002 46: 3133-3141; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in 23S rRNA Account for Intrinsic Resistance to Macrolides in Mycoplasma hominis and Mycoplasma fermentans and for Acquired Resistance to Macrolides in M. hominis S. Pereyre, P. Gonzalez, B. de Barbeyrac, A. Darnige, H. Renaudin, A. Charron, S. Raherison, C. Bébéar, and C. M. Bébéar Antimicrob. Agents Chemother. October 2002 46: 3142-3150; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Carboxyl Terminus of Peptidoglycan Stem Peptides Is a Determinant for Methicillin Resistance in Staphylococcus aureus Boudewijn L. M. de Jonge, Douglas Gage,, and Naxing Xu Antimicrob. Agents Chemother. October 2002 46: 3151-3155; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

ß-Lactamases in Ampicillin-Resistant Escherichia coli Isolates from Foods, Humans, and Healthy Animals Laura Briñas, Myriam Zarazaga, Yolanda Sáenz, Fernanda Ruiz-Larrea, and Carmen Torres Antimicrob. Agents Chemother. October 2002 46: 3156-3163; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical-Genetic Analysis and Distribution of DES-1, an Ambler Class A Extended-Spectrum ß-Lactamase from Desulfovibrio desulfuricans Anne-Sophie Morin, Laurent Poirel, Francine Mory, Roger Labia, and Patrice Nordmann Antimicrob. Agents Chemother. October 2002 46: 3215-3222; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

EBR-1, a Novel Ambler Subclass B1 ß-Lactamase from Empedobacter brevis Samuel Bellais, Delphine Girlich, Amal Karim, and Patrice Nordmann Antimicrob. Agents Chemother. October 2002 46: 3223-3227; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

DNA Sequence Analysis of DNA Gyrase and DNA Topoisomerase IV Quinolone Resistance-Determining Regions of Salmonella enterica Serovar Typhi and Serovar Paratyphi A Kenji Hirose, Ai Hashimoto, Kazumichi Tamura, Yoshiaki Kawamura, Takayuki Ezaki, Hiroko Sagara, and Haruo Watanabe Antimicrob. Agents Chemother. October 2002 46: 3249-3252; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in the aph(2")-Ic Gene Are Responsible for Increased Levels of Aminoglycoside Resistance Hae Kyung Lee, Sergei B. Vakulenko, Don B. Clewell, Stephen A. Lerner, and Joseph W. Chow Antimicrob. Agents Chemother. October 2002 46: 3253-3256; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Resistance-Nodulation-Cell Division Family Xenobiotic Efflux Pump in an Obligate Anaerobe, Porphyromonas gingivalis Takeshi Ikeda and Fuminobu Yoshimura Antimicrob. Agents Chemother. October 2002 46: 3257-3260; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penicillin-Binding Protein 1A, 2B, and 2X Alterations in Canadian Isolates of Penicillin-Resistant Streptococcus pneumoniae Kimberly A. Nichol, George G. Zhanel, and Daryl J. Hoban Antimicrob. Agents Chemother. October 2002 46: 3261-3264; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-11 Mutation in the ampC Promoter Increasing Resistance to ß-Lactams in a Clinical Escherichia coli Strain S. Corvec, N. Caroff, E. Espaze, J. Marraillac, and A. Reynaud Antimicrob. Agents Chemother. October 2002 46: 3265-3267; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Carbapenem-Resistant Pseudomonas aeruginosa in Malaysia Producing IMP-7 ß-Lactamase Siaw Eng Ho, Geetha Subramaniam, Selvi Palasubramaniam, and Parasakthi Navaratnam Antimicrob. Agents Chemother. October 2002 46: 3286-3287; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inducible AmpC ß-Lactamase of a New Member Enterobacteriaceae Richard Bonnet, Catherine Chanal, Elisabeth Ageron, Danielle Sirot, Christophe De Champs, Patrick Grimont, and Jacques Sirot Antimicrob. Agents Chemother. October 2002 46: 3316-3319; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gene Dosage and Linezolid Resistance in Enterococcus faecium and Enterococcus faecalis S. H. Marshall, C. J. Donskey, R. Hutton-Thomas, R. A. Salata, and L. B. Rice Antimicrob. Agents Chemother. October 2002 46: 3334-3336; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Comparison of the In Vitro Activity of the Glycylcycline Tigecycline (Formerly GAR-936) with Those of Tetracycline, Minocycline, and Doxycycline against Isolates of Nontuberculous Mycobacteria Richard J. Wallace, Jr., Barbara A. Brown-Elliott, Christopher J. Crist, Linda Mann, and Rebecca W. Wilson Antimicrob. Agents Chemother. October 2002 46: 3164-3167; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimicrobial Activity of GSQ1530, a New Heteroaromatic Polycyclic Compound Yigong Ge, Stacey Difuntorum, Sofia Touami, Ian Critchley, Roland Bürli, Vernon Jiang, Ken Drazan, and Heinz Moser Antimicrob. Agents Chemother. October 2002 46: 3168-3174; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

16-Bromoepiandrosterone, an Antimalarial Analogue of the Hormone Dehydroepiandrosterone, Enhances Phagocytosis of Ring Stage Parasitized Erythrocytes: a Novel Mechanism for Antimalarial Activity Kodjo Ayi, Giuliana Giribaldi, Aleksei Skorokhod, Evelin Schwarzer, Patrick T. Prendergast, and Paolo Arese Antimicrob. Agents Chemother. October 2002 46: 3180-3184; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ligands of the Peripheral Benzodiazepine Receptor Are Potent Inhibitors of Plasmodium falciparum and Toxoplasma gondii In Vitro Florence Dzierszinski, Alexandra Coppin, Marlene Mortuaire, Etienne Dewailly, Christian Slomianny, Jean-Claude Ameisen, Frederic DeBels, and Stanislas Tomavo Antimicrob. Agents Chemother. October 2002 46: 3197-3207; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Evaluation of a New Fluorescent Carboxyfluorescein Diacetate-Modified Microdilution Method for Antifungal Susceptibility Testing of Candida albicans Isolates Robert S. Liao, Robert P. Rennie, and James A. Talbot Antimicrob. Agents Chemother. October 2002 46: 3236-3242; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective, Multicenter Surveillance Study of Candida glabrata: Fluconazole and Itraconazole Susceptibility Profiles in Bloodstream, Invasive, and Colonizing Strains and Differences between Isolates from Three Urban Teaching Hospitals in New York City (Candida Susceptibility Trends Study, 1998 to 1999) Amar Safdar, Vishnu Chaturvedi, Brian S. Koll, Davise H. Larone, David S. Perlin, and Donald Armstrong Antimicrob. Agents Chemother. October 2002 46: 3268-3272; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of the New Oxazolidinone AZD2563 against Enterococci G. M. Eliopoulos, C. B. Wennersten, and R. C. Moellering, Jr. Antimicrob. Agents Chemother. October 2002 46: 3273-3275; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms D. R. Snydman, N. V. Jacobus, L. A. McDermott, R. Ruthazer, E. Goldstein, S. Finegold, L. Harrell, D. W. Hecht, S. Jenkins, C. Pierson, R. Venezia, J. Rihs, and S. L. Gorbach Antimicrob. Agents Chemother. October 2002 46: 3276-3279; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of In Vitro Activities of Gatifloxacin and Ciprofloxacin against Four Taxa of Rapidly Growing Mycobacteria Barbara A. Brown-Elliott, Richard J. Wallace, Jr., Christopher J. Crist, Linda Mann, and Rebecca W. Wilson Antimicrob. Agents Chemother. October 2002 46: 3283-3285; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Investigational Triazoles against Fusarium Species: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results Niki I. Paphitou, Luis Ostrosky-Zeichner, Victor L. Paetznick, Jose R. Rodriguez, Enuo Chen, and John H. Rex Antimicrob. Agents Chemother. October 2002 46: 3298-3300; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Occur Frequently in Elderly Patients in Japan Shin-ichi Yokota, Kiyoshi Sato, Osamu Kuwahara, Satoshi Habadera, Naoyuki Tsukamoto, Hironori Ohuchi, Hirotsugu Akizawa, Tetsuo Himi, and Nobuhiro Fujii Antimicrob. Agents Chemother. October 2002 46: 3311-3315; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Synergistic Interaction between Amphotericin B and Pentamidine against Scedosporium prolificans Javier Afeltra, Eric Dannaoui, Jacques F. G. M. Meis, Juan L. Rodriguez-Tudela, and Paul E. Verweij Antimicrob. Agents Chemother. October 2002 46: 3323-3326; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Effect of Prolonged Fluconazole Treatment on Candida albicans in Diffusion Chambers Implanted into Mice Peter G. Sohnle and Beth L. Hahn Antimicrob. Agents Chemother. October 2002 46: 3175-3179; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Effect and Pharmacodynamics of Cethromycin (ABT-773) in a Murine Pneumococcal Pneumonia Model Myo-Kyoung Kim, Wen Zhou, Pamela R. Tessier, Dawei Xuan, Min Ye, Charles H. Nightingale, and David P. Nicolau Antimicrob. Agents Chemother. October 2002 46: 3185-3192; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activity of Rifampin-Amikacin against Mycobacterium ulcerans in Mice Herve Dega, Abdelhalim Bentoucha, Jerome Robert, Vincent Jarlier, and Jacques Grosset Antimicrob. Agents Chemother. October 2002 46: 3193-3196; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Itraconazole Preexposure Attenuates the Efficacy of Subsequent Amphotericin B Therapy in a Murine Model of Acute Invasive Pulmonary Aspergillosis Russell E. Lewis, Randall A. Prince, Jingduan Chi, and Dimitrios P. Kontoyiannis Antimicrob. Agents Chemother. October 2002 46: 3208-3214; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Linezolid against Methicillin-Resistant or Vancomycin-Insensitive Staphylococcus aureus in a Model of Hematogenous Pulmonary Infection Katsunori Yanagihara, Yukihiro Kaneko, Toyomitsu Sawai, Yoshitsugu Miyazaki, Kazuhiro Tsukamoto, Yoichi Hirakata, Kazunori Tomono, Jun-Ichi Kadota, Takayoshi Tashiro, Ikuo Murata, and Shigeru Kohno Antimicrob. Agents Chemother. October 2002 46: 3288-3291; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Secretion of Interleukin-1 and Tumor Necrosis Factor Alpha by the Ketolide Antibiotic Telithromycin Fausto G. Araujo, Teri L. Slifer, and Jack S. Remington Antimicrob. Agents Chemother. October 2002 46: 3327-3330; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Intracellular Accumulation of Human Immunodeficiency Virus Protease Inhibitors Saye H. Khoo, Patrick G. Hoggard, Ian Williams, E. Rhiannon Meaden, Philippa Newton, Edmund G. Wilkins, Alan Smith, John F. Tjia, Judy Lloyd, Kevin Jones, Nick Beeching, Peter Carey, Barry Peters, and David J. Back Antimicrob. Agents Chemother. October 2002 46: 3228-3235; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Fluoroquinolones in Patients with Chronic Hepatitis C Virus-Induced Liver Failure H. Kojima, K. D. E. Kaita, K. Hawkins, J. Uhanova, and G. Y. Minuk Antimicrob. Agents Chemother. October 2002 46: 3280-3282; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives Wim Pluymers, Godwin Pais, Bénédicte Van Maele, Christophe Pannecouque, Valery Fikkert, Terrence R. Burke, Jr., Erik De Clercq, Myriam Witvrouw, Nouri Neamati, and Zeger Debyser Antimicrob. Agents Chemother. October 2002 46: 3292-3297; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Human Immunodeficiency Virus Type 1 Isolates by the Integrase Inhibitor L-731,988, a Diketo Acid Ryan Reinke, Deborah J. Lee, and W. Edward Robinson, Jr. Antimicrob. Agents Chemother. October 2002 46: 3301-3303; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Imiquimod 5-Percent Cream Does Not Alter the Natural History of Recurrent Herpes Genitalis: a Phase II, Randomized, Double-Blind, Placebo-Controlled Study Timothy W. Schacker, Marcus Conant, Christopher Thoming, Tamara Stanczak, Zengri Wang, and Michael Smith Antimicrob. Agents Chemother. October 2002 46: 3243-3248; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Simple Method for Assaying Colistin Methanesulfonate in Plasma and Urine Using High-Performance Liquid Chromatography Jian Li, Robert W. Milne, Roger L. Nation, John D. Turnidge, Kingsley Coulthard, and Jason Valentine Antimicrob. Agents Chemother. October 2002 46: 3304-3307; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of the Des-F(6)-Quinolone Garenoxacin (BMS-284756), in Comparison to Those of Ciprofloxacin and Ofloxacin, on Joint Cartilage in Immature Rats Eva Maria Kappel, Mehdi Shakibaei, Akintunde Bello, and Ralf Stahlmann Antimicrob. Agents Chemother. October 2002 46: 3320-3322; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Clarithromycin and Amoxicillin on Gastric Emptying in Rats Hiromi Endo, Hideo Yoshida, Yoshiro Kohno, and Tetsuya Suga Antimicrob. Agents Chemother. October 2002 46: 3331-3333; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Contribution of the C-8-Methoxy Group of Gatifloxacin to Inhibition of Type II Topoisomerases of Staphylococcus aureus Masaya Takei, Hideyuki Fukuda, Ryuta Kishii, Youko Kadowaki, Yukiko Atobe, and Masaki Hosaka Antimicrob. Agents Chemother. October 2002 46: 3337-3338; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.