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Mechanisms of Action:

Aleksander Patrzykat, Carol L. Friedrich, Lijuan Zhang, Valentina Mendoza, and Robert E. W. Hancock

Sublethal Concentrations of Pleurocidin-Derived Antimicrobial Peptides Inhibit Macromolecular Synthesis in Escherichia coli
Antimicrob. Agents Chemother. 2002 46: 605-614. [Abstract] [Full Text] [PDF]  

Henriette P. Burghoorn, Patricia Soteropoulos, Padmaja Paderu, Ryota Kashiwazaki, and David S. Perlin

Molecular Evaluation of the Plasma Membrane Proton Pump from Aspergillus fumigatus
Antimicrob. Agents Chemother. 2002 46: 615-624. [Abstract] [Full Text] [PDF]  

Casey Chun Zhou, Steven M. Swaney, Dean L. Shinabarger, and Brian J. Stockman

¹H Nuclear Magnetic Resonance Study of Oxazolidinone Binding to Bacterial Ribosomes
Antimicrob. Agents Chemother. 2002 46: 625-629. [Abstract] [Full Text] [PDF]  

Lyndal R. Emerson, Martin E. Nau, Rodger K. Martin, Dennis E. Kyle, Maryanne Vahey, and Dyann F. Wirth

Relationship between Chloroquine Toxicity and Iron Acquisition in Saccharomyces cerevisiae
Antimicrob. Agents Chemother. 2002 46: 787-796. [Abstract] [Full Text] [PDF]  

Gabriele Schmuck, Elke Roehrdanz, Richard K. Haynes, and Regine Kahl

Neurotoxic Mode of Action of Artemisinin
Antimicrob. Agents Chemother. 2002 46: 821-827. [Abstract] [Full Text] [PDF]  

José María Saugar, Teresa Alarcón, Susana López-Hernández, Manuel López-Brea, David Andreu, and Luis Rivas

Activities of Polymyxin B and Cecropin A-Melittin Peptide CA(1-8)M(1-18) against a Multiresistant Strain of Acinetobacter baumannii
Antimicrob. Agents Chemother. 2002 46: 875-878. [Abstract] [Full Text] [PDF]  

Mechanisms of Resistance:

Aroonwadee Chanawong, Fatima Hannachi M'Zali, John Heritage, Jian-Hui Xiong, and Peter Michael Hawkey

Three Cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China
Antimicrob. Agents Chemother. 2002 46: 630-637. [Abstract] [Full Text] [PDF]  

Véronique Dubois, Laurent Poirel, Caroline Marie, Corinne Arpin, Patrice Nordmann, and Claudine Quentin

Molecular Characterization of a Novel Class 1 Integron Containing bla_GES-1 and a Fused Product of aac(3)-Ib/aac(6")-Ib" Gene Cassettes in Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2002 46: 638-645. [Abstract] [Full Text] [PDF]  

Sergei Vakulenko and Dasantila Golemi

Mutant TEM ß-Lactamase Producing Resistance to Ceftazidime, Ampicillins, and ß-Lactamase Inhibitors
Antimicrob. Agents Chemother. 2002 46: 646-653. [Abstract] [Full Text] [PDF]  

Marja Pihlajamäki, Janne Kataja, Helena Seppälä, John Elliot, Maija Leinonen, Pentti Huovinen, and Jari Jalava

Ribosomal Mutations in Streptococcus pneumoniae Clinical Isolates
Antimicrob. Agents Chemother. 2002 46: 654-658. [Abstract] [Full Text] [PDF]  

Christopher Howard, Angela van Daal, Gregory Kelly, Jacqueline Schooneveldt, Graeme Nimmo, and Philip M. Giffard

Identification and Minisequencing-Based Discrimination of SHV ß-Lactamases in Nosocomial Infection-Associated Klebsiella pneumoniae in Brisbane, Australia
Antimicrob. Agents Chemother. 2002 46: 659-664. [Abstract] [Full Text] [PDF]  

Sylvia Valdezate, Ana Vindel, Aurora Echeita, Fernando Baquero, and Rafael Cantó

Topoisomerase II and IV Quinolone Resistance-Determining Regions in Stenotrophomonas maltophilia Clinical Isolates with Different Levels of Quinolone Susceptibility
Antimicrob. Agents Chemother. 2002 46: 665-671. [Abstract] [Full Text] [PDF]  

S. Raherison, P. Gonzalez, H. Renaudin, A. Charron, C. Bébéar, and C. M. Bébéar

Evidence of Active Efflux in Resistance to Ciprofloxacin and to Ethidium Bromide by Mycoplasma hominis
Antimicrob. Agents Chemother. 2002 46: 672-679. [Abstract] [Full Text] [PDF]  

Patricia A. Ropp, Mei Hu, Melanie Olesky, and Robert A. Nicholas

Mutations in ponA, the Gene Encoding Penicillin-Binding Protein 1, and a Novel Locus, penC, Are Required for High-Level Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae
Antimicrob. Agents Chemother. 2002 46: 769-777. [Abstract] [Full Text] [PDF]  

Laura J. V. Piddock, Maggie M. Johnson, S. Simjee, and L. Pumbwe

Expression of Efflux Pump Gene pmrA in Fluoroquinolone-Resistant and -Susceptible Clinical Isolates of Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2002 46: 808-812. [Abstract] [Full Text] [PDF]  

Laura J. V. Piddock and M. M. Johnson

Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2002 46: 813-820. [Abstract] [Full Text] [PDF]  

Antoine Giraud, Ivan Matic, Miroslav Radman, Michel Fons, and François Taddei

Mutator Bacteria as a Risk Factor in Treatment of Infectious Diseases
Antimicrob. Agents Chemother. 2002 46: 863-865. [Abstract] [Full Text] [PDF]  

Zhilan Zheng and Philip S. Stewart

Penetration of Rifampin through Staphylococcus epidermidis Biofilms
Antimicrob. Agents Chemother. 2002 46: 900-903. [Abstract] [Full Text] [PDF]  

Mariagrazia Perilli, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, and Gianfranco Amicosante

Characterization of a New Extended-Spectrum ß-Lactamase (TEM-87) Isolated in Proteus mirabilis during an Italian Survey
Antimicrob. Agents Chemother. 2002 46: 925-928. [Abstract] [Full Text] [PDF]  

Susceptibility:

Angela B. Brueggemann, Stacy L. Coffman, Paul Rhomberg, Holly Huynh, Laurel Almer, Angela Nilius, Robert Flamm, and Gary V. Doern

Fluoroquinolone Resistance in Streptococcus pneumoniae in United States since 1994-1995
Antimicrob. Agents Chemother. 2002 46: 680-688. [Abstract] [Full Text] [PDF]  

Shiri Navon-Venezia, Rina Feder, Leonid Gaidukov, Yehuda Carmeli, and Amram Mor

Antibacterial Properties of Dermaseptin S4 Derivatives with In Vivo Activity
Antimicrob. Agents Chemother. 2002 46: 689-694. [Abstract] [Full Text] [PDF]  

Julia Walochnik, Michael Duchêne, Karin Seifert, Andreas Obwaller, Thomas Hottkowitz, Gerhard Wiedermann, Hansjörg Eibl, and Horst Aspöck

Cytotoxic Activities of Alkylphosphocholines against Clinical Isolates of Acanthamoeba spp.
Antimicrob. Agents Chemother. 2002 46: 695-701. [Abstract] [Full Text] [PDF]  

D. T. A. Te Dorsthorst, P. E. Verweij, J. F. G. M. Meis, N. C. Punt, and J. W. Mouton

Comparison of Fractional Inhibitory Concentration Index with Response Surface Modeling for Characterization of In Vitro Interaction of Antifungals against Itraconazole-Susceptible and -Resistant Aspergillus fumigatus Isolates
Antimicrob. Agents Chemother. 2002 46: 702-707. [Abstract] [Full Text] [PDF]  

Virginia D. Shortridge, Ping Zhong, Zhensheng Cao, Jill M. Beyer, Laurel S. Almer, Nancy C. Ramer, Stella Z. Doktor, and Robert K. Flamm

Comparison of In Vitro Activities of ABT-773 and Telithromycin against Macrolide-Susceptible and -Resistant Streptococci and Staphylococci
Antimicrob. Agents Chemother. 2002 46: 783-786. [Abstract] [Full Text] [PDF]  

James J. Brendle, Abram Outlaw, Arvind Kumar, David W. Boykin, Donald A. Patrick, Richard R. Tidwell, and Karl A. Werbovetz

Antileishmanial Activities of Several Classes of Aromatic Dications
Antimicrob. Agents Chemother. 2002 46: 797-807. [Abstract] [Full Text] [PDF]  

Anthony D. Harris, Eli Perencevich, Mary-Claire Roghmann, Glenn Morris, Keith S. Kaye, and Judith A. Johnson

Risk Factors for Piperacillin-Tazobactam-Resistant Pseudomonas aeruginosa among Hospitalized Patients
Antimicrob. Agents Chemother. 2002 46: 854-858. [Abstract] [Full Text] [PDF]  

Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, and Helen Fernandez

In Vitro Activities of the Des-Fluoro(6) Quinolone BMS-284756 against Aerobic and Anaerobic Pathogens Isolated from Skin and Soft Tissue Animal and Human Bite Wound Infections
Antimicrob. Agents Chemother. 2002 46: 866-870. [Abstract] [Full Text] [PDF]  

R. Zbinden, V. Pünter, and A. von Graevenitz

In Vitro Activities of BAL9141, a Novel Broad-Spectrum Pyrrolidinone Cephalosporin, against Gram-Negative Nonfermenters
Antimicrob. Agents Chemother. 2002 46: 871-874. [Abstract] [Full Text] [PDF]  

Jan M. Bell and John D. Turnidge

High Prevalence of Oxacillin-Resistant Staphylococcus aureus Isolates from Hospitalized Patients in Asia-Pacific and South Africa: Results from SENTRY Antimicrobial Surveillance Program, 1998-1999
Antimicrob. Agents Chemother. 2002 46: 879-881. [Abstract] [Full Text] [PDF]  

John Scovill, Elizabeth Blank, Michael Konnick, Elizabeth Nenortas, and Theresa Shapiro

Antitrypanosomal Activities of Tryptanthrins
Antimicrob. Agents Chemother. 2002 46: 882-883. [Abstract] [Full Text] [PDF]  

Carmen Betriu, Iciar Rodríguez-Avial, Blas Ali Sánchez, María Gómez, Juan Álvarez, and Juan J. Picazo

In Vitro Activities of Tigecycline (GAR-936) against Recently Isolated Clinical Bacteria in Spain
Antimicrob. Agents Chemother. 2002 46: 892-895. [Abstract] [Full Text] [PDF]  

Mayumi Tanaka, Emi Yamazaki, Megumi Chiba, Kiyomi Yoshihara, Takaaki Akasaka, Makoto Takemura, and Kenichi Sato

In Vitro Antibacterial Activities of DQ-113, a Potent Quinolone, against Clinical Isolates
Antimicrob. Agents Chemother. 2002 46: 904-908. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Wataru Sugiura, Zene Matsuda, Yoshiyuki Yokomaku, Kurt Hertogs, Brendan Larder, Tsuyoshi Oishi, Aiko Okano, Teiichirou Shiino, Masashi Tatsumi, Masakazu Matsuda, Hanae Abumi, Noboru Takata, Satoshi Shirahata, Kaneo Yamada, Hiroshi Yoshikura, and Yoshiyuki Nagai

Interference between D30N and L90M in Selection and Development of Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2002 46: 708-715. [Abstract] [Full Text] [PDF]  

Gabriel Birkus, Michael J. M. Hitchcock, and Tomas Cihlar

Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors
Antimicrob. Agents Chemother. 2002 46: 716-723. [Abstract] [Full Text] [PDF]  

Nancee L. Oien, Roger J. Brideau, Todd A. Hopkins, Janet L. Wieber, Mary L. Knechtel, John A. Shelly, Robert A. Anstadt, Peter A. Wells, Roger A. Poorman, Audris Huang, Vallerie A. Vaillancourt, Terrance L. Clayton, John A. Tucker, and Michael W. Wathen

Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors
Antimicrob. Agents Chemother. 2002 46: 724-730. [Abstract] [Full Text] [PDF]  

Michael Maguire, Denise Shortino, Astrid Klein, Wendy Harris, Varsha Manohitharajah, Margaret Tisdale, Robert Elston, Jane Yeo, Sharon Randall, Fan Xu, Hayley Parker, Jackie May, and Wendy Snowden

Emergence of Resistance to Protease Inhibitor Amprenavir in Human Immunodeficiency Virus Type 1-Infected Patients: Selection of Four Alternative Viral Protease Genotypes and Influence of Viral Susceptibility to Coadministered Reverse Transcriptase Nucleoside Inhibitors
Antimicrob. Agents Chemother. 2002 46: 731-738. [Abstract] [Full Text] [PDF]  

Jeffry J. Leary, Robert Wittrock, Robert T. Sarisky, Adriana Weinberg, and Myron J. Levin

Susceptibilities of Herpes Simplex Viruses to Penciclovir and Acyclovir in Eight Cell Lines
Antimicrob. Agents Chemother. 2002 46: 762-768. [Abstract] [Full Text] [PDF]  

Clayton C. Huntley, William J. Weiss, Anna Gazumyan, Aron Buklan, Boris Feld, William Hu, Thomas R. Jones, Timothy Murphy, Antonia A. Nikitenko, Bryan O'Hara, Gregory Prince, Susan Quartuccio, Yuri E. Raifeld, Philip Wyde, and John F. O'Connell

RFI-641, a Potent Respiratory Syncytial Virus Inhibitor
Antimicrob. Agents Chemother. 2002 46: 841-847. [Abstract] [Full Text] [PDF]  

Adrian S. Ray, Zhenjun Yang, Chung K. Chu, and Karen S. Anderson

Novel Use of a Guanosine Prodrug Approach To Convert 2',3'-Didehydro-2',3'-Dideoxyguanosine into a Viable Antiviral Agent
Antimicrob. Agents Chemother. 2002 46: 887-891. [Abstract] [Full Text] [PDF]  

Rieneke M. E. van Praag, Elisabeth C. M. van Weert, Rolf P. G van Heeswijk, Xiao-Jian Zhou, Jean-Pierre Sommadossi, Suzanne Jurriaans, Joep M. A. Lange, Richard M. W. Hoetelmans, and Jan M. Prins

Stable Concentrations of Zidovudine, Stavudine, Lamivudine, Abacavir, and Nevirapine in Serum and Cerebrospinal Fluid during 2 Years of Therapy
Antimicrob. Agents Chemother. 2002 46: 896-899. [Abstract] [Full Text] [PDF]  

P. Richard Harrigan and Brendan A. Larder

Extent of Cross-Resistance between Agents Used To Treat Human Immunodeficiency Virus Type 1 Infection in Clinically Derived Isolates
Antimicrob. Agents Chemother. 2002 46: 909-912. [Abstract] [Full Text] [PDF]  

G. L. Drusano, K. H. P. Moore, J. P. Kleim, W. Prince, and A. Bye

Rational Dose Selection for a Nonnucleoside Reverse Transcriptase Inhibitor through Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation
Antimicrob. Agents Chemother. 2002 46: 913-916. [Abstract] [Full Text] [PDF]  

Pharmacology:

Julie A. Stone, Sherry D. Holland, Peter J. Wickersham, Andrew Sterrett, Michael Schwartz, Cynthia Bonfiglio, Michael Hesney, Gregory A. Winchell, Paul J. Deutsch, Howard Greenberg, Thomas L. Hunt, and Scott A. Waldman

Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men
Antimicrob. Agents Chemother. 2002 46: 739-745. [Abstract] [Full Text] [PDF]  

Mark Sale, Brian M. Sadler, and Daniel S. Stein

Pharmacokinetic Modeling and Simulations of Interaction of Amprenavir and Ritonavir
Antimicrob. Agents Chemother. 2002 46: 746-754. [Abstract] [Full Text] [PDF]  

Katrina L. Mealey, Rola Barhoumi, Robert C. Burghardt, Stephen Safe, and Deborah T. Kochevar

Doxycycline Induces Expression of P Glycoprotein in MCF-7 Breast Carcinoma Cells
Antimicrob. Agents Chemother. 2002 46: 755-761. [Abstract] [Full Text] [PDF]  

Ihor Bekersky, Robert M. Fielding, Dawna E. Dressler, Jean W. Lee, Donald N. Buell, and Thomas J. Walsh

Pharmacokinetics, Excretion, and Mass Balance of Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate in Humans
Antimicrob. Agents Chemother. 2002 46: 828-833. [Abstract] [Full Text] [PDF]  

Ihor Bekersky, Robert M. Fielding, Dawna E. Dressler, Jean W. Lee, Donald N. Buell, and Thomas J. Walsh

Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate
Antimicrob. Agents Chemother. 2002 46: 834-840. [Abstract] [Full Text] [PDF]  

Rob E. Aarnoutse, Corrien P. W. G. M. Verweij-van Wissen, Eleonora W. J. van Ewijk-Beneken Kolmer, Eveline W. Wuis, Peter P. Koopmans, Yechiel A. Hekster, and David M. Burger

International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma
Antimicrob. Agents Chemother. 2002 46: 884-886. [Abstract] [Full Text] [PDF]  

Jun-Ichi Kadota, Yuji Ishimatsu, Tetsuji Iwashita, Yuichi Matsubara, Kazunori Tomono, Masao Tateno, Roza Ishihara, Claudette Muller-Serieys, and Shigeru Kohno

Intrapulmonary Pharmacokinetics of Telithromycin, a New Ketolide, in Healthy Japanese Volunteers
Antimicrob. Agents Chemother. 2002 46: 917-921. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

Brian J. Angus, Itaporn Thaiaporn, Kenechanh Chanthapadith, Yupin Suputtamongkol, and Nicholas J. White

Oral Artesunate Dose-Response Relationship in Acute Falciparum Malaria
Antimicrob. Agents Chemother. 2002 46: 778-782. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Johann Truccolo, Françoise Charavay, Fabrice Merien, and Philippe Perolat

Quantitative PCR Assay To Evaluate Ampicillin, Ofloxacin, and Doxycycline for Treatment of Experimental Leptospirosis
Antimicrob. Agents Chemother. 2002 46: 848-853. [Abstract] [Full Text] [PDF]  

Araceli Parra, Carmen Ponte, Carlos Cenjor, Gloria García-Calvo, María José Giménez, Lorenzo Aguilar, and Francisco Soriano

Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model
Antimicrob. Agents Chemother. 2002 46: 859-862. [Abstract] [Full Text] [PDF]  

K. V. Clemons, M. Martinez, L. Calderon, and D. A. Stevens

Efficacy of Ravuconazole in Treatment of Systemic Murine Histoplasmosis
Antimicrob. Agents Chemother. 2002 46: 922-924. [Abstract] [Full Text] [PDF]  

Vanessa Yardley, Anis A. Khan, Michael B. Martin, Teri R. Slifer, Fausto G. Araujo, Silvia N. J. Moreno, Roberto Docampo, Simon L. Croft, and Eric Oldfield

In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii
Antimicrob. Agents Chemother. 2002 46: 929-931. [Abstract] [Full Text] [PDF]  

Letters:

Guillem Prats, Elisenda Miro, Beatriz Mirelis, Laurent Poirel, Samuel Bellais, and Patrice Nordmann

First Isolation of a Carbapenem-Hydrolyzing ß-Lactamase in Pseudomonas aeruginosa in Spain
Antimicrob. Agents Chemother. 2002 46: 932-933. [Full Text] [PDF]  

Franz-Josef Schmitz, Mechthild Boos, Susanne Mayer, Karl Köhrer, Sibylle Scheuring, and Ad C. Fluit

In Vitro Activities of Novel Des-Fluoro(6) Quinolone BMS-284756 against Mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus Selected with Different Quinolones
Antimicrob. Agents Chemother. 2002 46: 934-935. [Full Text] [PDF]  

P. Villani, M. B. Regazzi, F. Marubbi, P. Viale, L. Pagani, F. Cristini, B. Cadeo, G. Carosi, and R. Bergomi

Cerebrospinal Fluid Linezolid Concentrations in Postneurosurgical Central Nervous System Infections
Antimicrob. Agents Chemother. 2002 46: 936-937. [Full Text] [PDF]  

Jeff S. McDermott, Heinz J. Salmen, Bryan F. Cox, and Gary A. Gintant

Importance of Species Selection in Arrythmogenic Models of Q-T Interval Prolongation
Antimicrob. Agents Chemother. 2002 46: 938-939. [Full Text] [PDF]  

Errata:

Richard G. Nelson and Andre Rosowsky

Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations
Antimicrob. Agents Chemother. 2002 46: 940. [Full Text] [PDF]  

Author's Correction:

Rieneke M. E. van Praag, Sjoerd Repping, Jan W. A. de Vries, Joep M. A. Lange, Richard M. W. Hoetelmans, and Jan M. Prins

Pharmacokinetic Profiles of Nevirapine and Indinavir in Various Fractions of Seminal Plasma
Antimicrob. Agents Chemother. 2002 46: 941. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.