Contents: May 2002, Volume 46, Issue 5        Minireviews        Chemistry; Biosynthesis        Mechanisms of Resistance        Susceptibility        Antiviral Agents        Experimental Therapeutics        Analytical Procedures        Pharmacology        Mechanisms of Action Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Antiparasitic Agent Atovaquone Aaron L. Baggish and David R. Hill Antimicrob. Agents Chemother. May 2002 46: 1163-1173; [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Biosynthetic Gene Cluster of Simocyclinone, a Natural Multihybrid Antibiotic A. Trefzer, S. Pelzer, J. Schimana, S. Stockert, C. Bihlmaier, H.-P. Fiedler, K. Welzel, A. Vente, and A. Bechthold Antimicrob. Agents Chemother. May 2002 46: 1174-1182; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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TEM-80, a Novel Inhibitor-Resistant ß-Lactamase in a Clinical Isolate of Enterobacter cloacae Corinne Arpin, Roger Labia, Véronique Dubois, Patrick Noury, Muriel Souquet, and Claudine Quentin Antimicrob. Agents Chemother. May 2002 46: 1183-1189; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Origin and Evolution of the AmpC ß-Lactamases of Citrobacter freundii Miriam Barlow and Barry G. Hall Antimicrob. Agents Chemother. May 2002 46: 1190-1198; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Group A Streptococcus Strains with Different Mechanisms of Macrolide Resistance Edouard Bingen, Roland Leclercq, Frédéric Fitoussi, Naïma Brahimi, Brigitte Malbruny, Dominique Deforche, and Robert Cohen Antimicrob. Agents Chemother. May 2002 46: 1199-1203; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fitness Cost of Chromosomal Drug Resistance-Conferring Mutations Peter Sander, Burkhard Springer, Therdsak Prammananan, Antje Sturmfels, Martin Kappler, Michel Pletschette, and Erik C. Böttger Antimicrob. Agents Chemother. May 2002 46: 1204-1211; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

ColE1-Like Plasmid pIP843 of Klebsiella pneumoniae Encoding Extended-Spectrum ß-Lactamase CTX-M-17 Van Cao, Thierry Lambert, and Patrice Courvalin Antimicrob. Agents Chemother. May 2002 46: 1212-1217; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Missense Mutation in the fabB (ß-Ketoacyl-Acyl Carrier Protein Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli Suzanne Jackowski, Yong-Mei Zhang, Allen C. Price, Stephen W. White, and Charles O. Rock Antimicrob. Agents Chemother. May 2002 46: 1246-1252; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of Essential Residues in the Erm(B) rRNA Methyltransferase of Clostridium perfringens Kylie A. Farrow, Dena Lyras, Galina Polekhina, Katerina Koutsis, Michael W. Parker, and Julian I. Rood Antimicrob. Agents Chemother. May 2002 46: 1253-1261; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Plasmids Carrying CMY-2 from Expanded-Spectrum Cephalosporin-Resistant Salmonella Strains Isolated in the United States between 1996 and 1998 A. Carattoli, F. Tosini, W. P. Giles, M. E. Rupp, S. H. Hinrichs, F. J. Angulo, T. J. Barrett, and P. D. Fey Antimicrob. Agents Chemother. May 2002 46: 1269-1272; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Amino Acid Alterations in Penicillin-Binding Proteins (PBPs) 1a, 2b, and 2x on PBP Affinities of Penicillin, Ampicillin, Amoxicillin, Cefditoren, Cefuroxime, Cefprozil, and Cefaclor in 18 Clinical Isolates of Penicillin-Susceptible, -Intermediate, and -Resistant Pneumococci Kensuke Nagai, Todd A. Davies, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. May 2002 46: 1273-1280; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Widespread Distribution of a Tet W Determinant among Tetracycline-Resistant Isolates of the Animal Pathogen Arcanobacterium pyogenes Stephen J. Billington, J. Glenn Songer, and B. Helen Jost Antimicrob. Agents Chemother. May 2002 46: 1281-1287; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization and Movement of the Class 1 Integron Known as Tn2521 and Tn1405 Sally R. Partridge, Heidi J. Brown, and Ruth M. Hall Antimicrob. Agents Chemother. May 2002 46: 1288-1294; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Presence of a Group II Intron in a Multiresistant Serratia marcescens Strain That Harbors Three Integrons and a Novel Gene Fusion Daniela Centrón and Paul H. Roy Antimicrob. Agents Chemother. May 2002 46: 1402-1409; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

tcrB, a Gene Conferring Transferable Copper Resistance in Enterococcus faecium: Occurrence, Transferability, and Linkage to Macrolide and Glycopeptide Resistance Henrik Hasman and Frank M. Aarestrup Antimicrob. Agents Chemother. May 2002 46: 1410-1416; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Prevalence of KatG Ser315Thr Substitution among Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates from Northwestern Russia, 1996 to 2001 Igor Mokrousov, Olga Narvskaya, Tatiana Otten, Elena Limeschenko, Lidia Steklova, and Boris Vyshnevskiy Antimicrob. Agents Chemother. May 2002 46: 1417-1424; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmidic Extended-Spectrum ß-Lactamases in Vibrio cholerae O1 El Tor Isolates in Argentina Alejandro Petroni, Alejandra Corso, Roberto Melano, María Luisa Cacace, Ana María Bru, Alicia Rossi, and Marcelo Galas Antimicrob. Agents Chemother. May 2002 46: 1462-1468; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bloodstream Infections by Extended-Spectrum ß-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Children: Epidemiology and Clinical Outcome Yun-Kyung Kim, Hyunjoo Pai, Hoan-Jong Lee, Su-Eun Park, Eun-Hwa Choi, Jungmin Kim, Je-Hak Kim, and Eui-Chong Kim Antimicrob. Agents Chemother. May 2002 46: 1481-1491; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Accessory Gene Regulator (agr) Locus in Geographically Diverse Staphylococcus aureus Isolates with Reduced Susceptibility to Vancomycin George Sakoulas, George M. Eliopoulos, Robert C. Moellering, Jr., Christine Wennersten, Lata Venkataraman, Richard P. Novick, and Howard S. Gold Antimicrob. Agents Chemother. May 2002 46: 1492-1502; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antagonism between Aminoglycosides and ß-Lactams in a Methicillin-Resistant Staphylococcus aureus Isolate Involves Induction of an Aminoglycoside-Modifying Enzyme Takashi Ida, Ryoichi Okamoto, Masato Nonoyama, Kazuhiko Irinoda, Mizuyo Kurazono, and Matsuhisa Inoue Antimicrob. Agents Chemother. May 2002 46: 1516-1521; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chromosomal System for Studying AmpC-Mediated ß-Lactam Resistance Mutation in Escherichia coli Joseph F. Petrosino, Amanda R. Pendleton, Joel H. Weiner, and Susan M. Rosenberg Antimicrob. Agents Chemother. May 2002 46: 1535-1539; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

30S Ribosomal Subunit Assembly Is a Target for Inhibition by Aminoglycosides in Escherichia coli Roopal Mehta and W. Scott Champney Antimicrob. Agents Chemother. May 2002 46: 1546-1549; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Mg2+-Dependent Oxytetracycline Resistance Determinant Tet 34 in Vibrio Isolates from Marine Fish Intestinal Contents Lisa Nonaka and Satoru Suzuki Antimicrob. Agents Chemother. May 2002 46: 1550-1552; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association of Metronidazole Resistance and Natural Competence in Helicobacter pylori Yu-Ching Yeh, Kai-Chin Chang, Jyh-Chin Yang, Chi-Tai Fang, and Jin-Town Wang Antimicrob. Agents Chemother. May 2002 46: 1564-1567; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

rpoB Mutation Conferring Rifampin Resistance in Streptococcus pyogenes Hélène Aubry-Damon, Marc Galimand, Guy Gerbaud, and Patrice Courvalin Antimicrob. Agents Chemother. May 2002 46: 1571-1573; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Macrolide and Tetracycline Resistance and Molecular Relationships of Clinical Strains of Streptococcus agalactiae Esther Culebras, Iciar Rodriguez-Avial, Carmen Betriu, Montserrat Redondo, and Juan J. Picazo Antimicrob. Agents Chemother. May 2002 46: 1574-1576; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Outbreak of Infections Caused by Enterobacter cloacae Producing the Integron-Associated ß-Lactamase IBC-1 in a Neonatal Intensive Care Unit of a Greek Hospital Georgia Kartali, Eva Tzelepi, Spyros Pournaras, Constantina Kontopoulou, Fanourios Kontos, Danai Sofianou, Antonios N. Maniatis, and Athanassios Tsakris Antimicrob. Agents Chemother. May 2002 46: 1577-1580; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Site-Specific Recombination with the Chromosomal tRNALeu Gene by the Large Conjugative Haemophilus Resistance Plasmid Ioanna D. Dimopoulou, Joanne E. Russell, Zaini Mohd-Zain, Rebecca Herbert, and Derrick W. Crook Antimicrob. Agents Chemother. May 2002 46: 1602-1603; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Laboratory-Derived, High-Level Ampicillin-Resistant Salmonella enterica Serovar Typhimurium Strain That Caused Meningitis in an Infant Cheng-Hsun Chiu, Chishih Chu, Lin-Hui Su, Wan-Yu Wu, and Tsu-Lan Wu Antimicrob. Agents Chemother. May 2002 46: 1604-1606; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Susceptibilities of Mycoplasma fermentans and Mycoplasma hyorhinis to Membrane-Active Peptides and Enrofloxacin in Human Tissue Cell Cultures Ran Nir-Paz, Marie-Christine Prévost, Pierre Nicolas, Alain Blanchard, and Henri Wróblewski Antimicrob. Agents Chemother. May 2002 46: 1218-1225; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Activity of Licochalcone A against Spore-Forming Bacteria Ryo-Ichi Tsukiyama, Harumi Katsura, Nozomu Tokuriki, and Makio Kobayashi Antimicrob. Agents Chemother. May 2002 46: 1226-1230; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

NB2001, a Novel Antibacterial Agent with Broad-Spectrum Activity and Enhanced Potency against ß-Lactamase-Producing Strains Qing Li, Jean Y. Lee, Rosario Castillo, Mark S. Hixon, Catherine Pujol, Venkata Ramana Doppalapudi, H. Michael Shepard, Geoffrey M. Wahl, Thomas J. Lobl, and Ming Fai Chan Antimicrob. Agents Chemother. May 2002 46: 1262-1268; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in Canada during 2000 Donald E. Low, Joyce de Azavedo, Karl Weiss, Tony Mazzulli, Magdalena Kuhn, Deirdre Church, Kevin Forward, George Zhanel, Andrew Simor, and A. McGeer Antimicrob. Agents Chemother. May 2002 46: 1295-1301; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Compounds Found in Propolis on Streptococcus mutans Growth and on Glucosyltransferase Activity Hyun Koo, Pedro L. Rosalen, Jaime A. Cury, Yong K. Park, and William H. Bowen Antimicrob. Agents Chemother. May 2002 46: 1302-1309; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Purification, Characterization, and Identification of Novel Inhibitors of the ß-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) from Staphylococcus aureus Xin He and Kevin A. Reynolds Antimicrob. Agents Chemother. May 2002 46: 1310-1318; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activity of Quinupristin-Dalfopristin Combined with Other Antibiotics against Vancomycin-Resistant Enterococci G. M. Eliopoulos and C. B. Wennersten Antimicrob. Agents Chemother. May 2002 46: 1319-1324; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Chemically Modified Tetracycline (CMT-3) Is a New Antifungal Agent Yu Liu, Maria E. Ryan, Hsi-Ming Lee, Sanford Simon, George Tortora, Carol Lauzon, Michael K. Leung, and Lorne M. Golub Antimicrob. Agents Chemother. May 2002 46: 1447-1454; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potato Dextrose Agar Antifungal Susceptibility Testing for Yeasts and Molds: Evaluation of Phosphate Effect on Antifungal Activity of CMT-3 Yu Liu, George Tortora, Maria E. Ryan, Hsi-Ming Lee, and Lorne M. Golub Antimicrob. Agents Chemother. May 2002 46: 1455-1461; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interactions of Artemisinin with Atovaquone, Quinine, and Mefloquine against Plasmodium falciparum S. Gupta, M. M. Thapar, W. H. Wernsdorfer, and A. Björkman Antimicrob. Agents Chemother. May 2002 46: 1510-1515; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of New Fluoroquinolones, Ketolides, and Other Antimicrobials against Blood Culture Isolates of Viridans Group Streptococci from across Canada, 2000 Andrea S. Gershon, Joyce C. S. de Azavedo, Allison McGeer, Krystyna I. Ostrowska, Deirdre Church, Daryl J. Hoban, Godfrey K. M. Harding, Karl Weiss, Lewis Abbott, Fiona Smaill, Marie Gourdeau, Gilles Murray, and Donald E. Low Antimicrob. Agents Chemother. May 2002 46: 1553-1556; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Posaconazole, Itraconazole, Voriconazole, Amphotericin B, and Fluconazole against 37 Clinical Isolates of Zygomycetes Qiu N. Sun, Annette W. Fothergill, Dora I. McCarthy, Michael G. Rinaldi, and John R. Graybill Antimicrob. Agents Chemother. May 2002 46: 1581-1582; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Free and Lipid Formulations of Amphotericin B and Nystatin against Clinical Isolates of Coccidioides immitis at Various Saprobic Stages Gloria M. González, Rolando Tijerina, Deanna A. Sutton, John R. Graybill, and Michael G. Rinaldi Antimicrob. Agents Chemother. May 2002 46: 1583-1585; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Linezolid against Clostridium difficile T. Peláez, R. Alonso, C. Pérez, L. Alcalá, O. Cuevas, and E. Bouza Antimicrob. Agents Chemother. May 2002 46: 1617-1618; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Characterization of Imidazo[4,5-d]Pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus Nucleoside Triphosphatase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme Peter Borowski, Melanie Lang, Annemarie Haag, Herbert Schmitz, Joonho Choe, Huan-Ming Chen, and Ramachandra S. Hosmane Antimicrob. Agents Chemother. May 2002 46: 1231-1239; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Wild-Type and Cidofovir-Resistant Strains of Camelpox, Cowpox, Monkeypox, and Vaccinia Viruses Donald F. Smee, Robert W. Sidwell, Debbie Kefauver, Mike Bray, and John W. Huggins Antimicrob. Agents Chemother. May 2002 46: 1329-1335; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Human Immunodeficiency Virus Interactions of SCH-C (SCH 351125), a CCR5 Antagonist, with Other Antiretroviral Agents In Vitro Cécile L. Tremblay, Françoise Giguel, Christopher Kollmann, Yongbiao Guan, Ting-Chao Chou, Bahige M. Baroudy, and Martin S. Hirsch Antimicrob. Agents Chemother. May 2002 46: 1336-1339; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants Raymond F. Schinazi, John Mellors, Holly Bazmi, Sharon Diamond, Sena Garber, Karen Gallagher, Romas Geleziunas, Ron Klabe, Michael Pierce, Marlene Rayner, Jing-Tao Wu, Hangchun Zhang, Jennifer Hammond, Lee Bacheler, Douglas J. Manion, Michael J. Otto, Lieven Stuyver, George Trainor, Dennis C. Liotta, and Susan Erickson-Viitanen Antimicrob. Agents Chemother. May 2002 46: 1394-1401; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Specific Zidovudine Resistance Mutations and Substrate Structure on Nucleotide-Dependent Primer Unblocking by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Peter R. Meyer, Suzanne E. Matsuura, Adviye A. Tolun, Ingrid Pfeifer, Antero G. So, John W. Mellors, and Walter A. Scott Antimicrob. Agents Chemother. May 2002 46: 1540-1545; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Immunodeficiency Virus (HIV) Type 1 Reverse Transcriptase Resistance Mutations in Hepatitis B Virus (HBV)-HIV-Coinfected Patients Treated for HBV Chronic Infection Once Daily with 10 Milligrams of Adefovir Dipivoxil Combined with Lamivudine Constance Delaugerre, Anne-Geneviève Marcelin, Vincent Thibault, Gilles Peytavin, Tony Bombled, Marie-Valérie Bochet, Christine Katlama, Yves Benhamou, and Vincent Calvez Antimicrob. Agents Chemother. May 2002 46: 1586-1588; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Pharmacokinetics of Amprenavir Coadministered with Grapefruit Juice D. Demarles, C. Gillotin, S. Bonaventure-Paci, I. Vincent, S. Fosse, and A. M. Taburet Antimicrob. Agents Chemother. May 2002 46: 1589-1590; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases , , and Gabriel Birkus, Miroslav Hájek, Pavel Kramata, Ivan Votruba, Antonín Holy, and Berta Otová Antimicrob. Agents Chemother. May 2002 46: 1610-1613; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Efficacies of Fluconazole, Caspofungin, and Amphotericin B in Candida glabrata-Infected p47phox-/- Knockout Mice Justina Y. Ju, Cynthia Polhamus, Kieren A. Marr, Steven M. Holland, and John E. Bennett Antimicrob. Agents Chemother. May 2002 46: 1240-1245; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Specific Antibodies against Streptococcus pneumoniae on Pharmacodynamic Parameters of ß-Lactams in a Mouse Sepsis Model J. Casal, L. Aguilar, I. Jado, J. Yuste, M. J. Giménez, J. Prieto, and A. Fenoll Antimicrob. Agents Chemother. May 2002 46: 1340-1344; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Activity and Efficacy of Linezolid in a Rat Model of Pneumococcal Pneumonia Martha J. Gentry-Nielsen, Keith M. Olsen, and Laurel C. Preheim Antimicrob. Agents Chemother. May 2002 46: 1345-1351; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Posaconazole against Coccidioides immitis Gloria M. González, Rolando Tijerina, Laura K. Najvar, Rosie Bocanegra, Michael Rinaldi, David Loebenberg, and John R. Graybill Antimicrob. Agents Chemother. May 2002 46: 1352-1356; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antifungal Activities of TAK-456, a Novel Oral Triazole with a Broad Antifungal Spectrum Noboru Tsuchimori, Ryogo Hayashi, Naomi Kitamoto, Kentaro Asai, Tomoyuki Kitazaki, Yuji Iizawa, Katsumi Itoh, and Kenji Okonogi Antimicrob. Agents Chemother. May 2002 46: 1388-1393; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Assessment of Clarithromycin in a Murine Model of Pneumococcal Pneumonia Pamela R. Tessier, Myo-Kyoung Kim, Wen Zhou, Dawei Xuan, Chonghua Li, Min Ye, Charles H. Nightingale, and David P. Nicolau Antimicrob. Agents Chemother. May 2002 46: 1425-1434; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Metronidazole, Tetracycline, and Bismuth-Metronidazole-Tetracycline Triple Therapy in the Helicobacter pylori SS1 Mouse Model after 1 Day of Dosing: Development of an H. pylori Lead Selection Model Christine F. Sizemore, Joel D. Quispe, Karen M. Amsler, Todd C. Modzelewski, Jayson J. Merrill, D. Andrew Stevenson, Lorie A. Foster, and Andrew M. Slee Antimicrob. Agents Chemother. May 2002 46: 1435-1440; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Levofloxacin, Alatrofloxacin, and Vancomycin for Prophylaxis and Treatment of Experimental Foreign-Body-Associated Infection by Methicillin-Resistant Staphylococcus aureus Pierre Vaudaux, Patrice Francois, Carmelo Bisognano, Jacques Schrenzel, and Daniel P. Lew Antimicrob. Agents Chemother. May 2002 46: 1503-1509; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, and John C. Rotschafer Antimicrob. Agents Chemother. May 2002 46: 1561-1563; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Different Aminoglycoside-Resistant Phenotypes in a Rabbit Staphylococcus aureus Endocarditis Infection Model N. Asseray, J. Caillon, N. Roux, C. Jacqueline, R. Bismuth, M. F. Kergueris, G. Potel, and D. Bugnon Antimicrob. Agents Chemother. May 2002 46: 1591-1593; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Design and Antileishmanial Activity of Amphotericin B-Loaded Stable Ionic Amphiphile Biovector Formulations P. M. Loiseau, L. Imbertie, C. Bories, D. Betbeder, and I. De Miguel Antimicrob. Agents Chemother. May 2002 46: 1597-1601; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gemifloxacin Is Efficacious against Penicillin-Resistant and Quinolone-Resistant Pneumococci in Experimental Meningitis Philippe Cottagnoud, Fernando Acosta, Marianne Cottagnoud, and Martin G. Täuber Antimicrob. Agents Chemother. May 2002 46: 1607-1609; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Change in Colony Morphology of Candida lusitaniae in Association with Development of Amphotericin B Resistance Nancy B. McClenny, Haihua Fei, Ellen J. Baron, Ana C. Gales, Allison Houston, Richard J. Hollis, and Michael A. Pfaller Antimicrob. Agents Chemother. May 2002 46: 1325-1328; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Plasmodium falciparum Drug Sensitivity Assay: Inhibition of Parasite Growth by Incorporation of Stomatocytogenic Amphiphiles into the Erythrocyte Membrane Hanne L. Ziegler, Dan Stærk, Jette Christensen, Lars Hviid, Henry Hägerstrand, and Jerzy W. Jaroszewski Antimicrob. Agents Chemother. May 2002 46: 1441-1446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacokinetics of Amino Acid Phosphoramidate Monoesters of Zidovudine in Rats Heng Song, George W. Griesgraber, Carston R. Wagner, and Cheryl L. Zimmerman Antimicrob. Agents Chemother. May 2002 46: 1357-1363; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Telithromycin (HMR 3647) on Polymorphonuclear Neutrophil Killing of Staphylococcus aureus in Comparison with Roxithromycin D. Vazifeh, H. Abdelghaffar, and M. T. Labro Antimicrob. Agents Chemother. May 2002 46: 1364-1374; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

PEPT1-Mediated Cefixime Uptake into Human Intestinal Epithelial Cells Is Increased by Ca2+ Channel Blockers Uwe Wenzel, Sabine Kuntz, Simone Diestel, and Hannelore Daniel Antimicrob. Agents Chemother. May 2002 46: 1375-1380; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nonparametric Population Pharmacokinetic Analysis of Amikacin in Neonates, Infants, and Children J. M. Tréluyer, Y. Merlé, S. Tonnelier, E. Rey, and G. Pons Antimicrob. Agents Chemother. May 2002 46: 1381-1387; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intrapulmonary Pharmacokinetics of Linezolid John E. Conte, Jr., Jeffrey A. Golden, Juliana Kipps, and Elisabeth Zurlinden Antimicrob. Agents Chemother. May 2002 46: 1475-1480; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats Ying Lan Zhao, Xiao Bo Cen, Masafumi Ito, Keiko Yokoyama, Kenji Takagi, Kiyoyuki Kitaichi, Masayuki Nadai, Michio Ohta, Kenzo Takagi, and Takaaki Hasegawa Antimicrob. Agents Chemother. May 2002 46: 1522-1528; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Piperacillin-Tazobactam in Anuric Intensive Care Patients during Continuous Venovenous Hemodialysis Silke C. Mueller, Jolanta Majcher-Peszynska, Heiko Hickstein, Astrid Francke, Annette Pertschy, Martin Schulz, Ralf Mundkowski, and Bernd Drewelow Antimicrob. Agents Chemother. May 2002 46: 1557-1560; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Azithromycin in Plasma and Tonsil Tissue after Repeated Oral Administration of 10 or 20 Milligrams per Kilogram in Pediatric Patients Corrado Blandizzi, Tecla Malizia, Giovanna Batoni, Emilia Ghelardi, Fabio Baschiera, Paolo Bruschini, Sonia Senesi, Mario Campa, and Mario Del Tacca Antimicrob. Agents Chemother. May 2002 46: 1594-1596; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction between Grapefruit Juice and Praziquantel in Humans Nelly Castro, Helgi Jung, Roberto Medina, Dinora González-Esquivel, Mario Lopez, and Julio Sotelo Antimicrob. Agents Chemother. May 2002 46: 1614-1616; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Interactions between Biocide Cationic Agents and Bacterial Biofilms C. Campanac, L. Pineau, A. Payard, G. Baziard-Mouysset, and C. Roques Antimicrob. Agents Chemother. May 2002 46: 1469-1474; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Crystal Structure of (-)-Mefloquine Hydrochloride Reveals Consistency of Configuration with Biological Activity Jean M. Karle and Isabella L. Karle Antimicrob. Agents Chemother. May 2002 46: 1529-1534; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of Interaction of Fluoroquinolones with Lipopolysaccharides B. Lindner, A. Wiese, K. Brandenburg, U. Seydel, and A. Dalhoff Antimicrob. Agents Chemother. May 2002 46: 1568-1570; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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