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Minireviews:

Karidia Diallo, Matthias Götte, and M. A. Wainberg

Molecular Impact of the M184V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
Antimicrob. Agents Chemother. 2003 47: 3377-3383. [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Reine Note, Caroline Maisonneuve, Philippe Lettéron, Gilles Peytavin, Fatima Djouadi, Anissa Igoudjil, Marie-Christine Guimont, Michel Biour, Dominique Pessayre, and Bernard Fromenty

Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments
Antimicrob. Agents Chemother. 2003 47: 3384-3392. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sandra L. Preston, Peter J. Piliero, John A. Bilello, Daniel S. Stein, William T. Symonds, and George L. Drusano

In Vitro-In Vivo Model for Evaluating the Antiviral Activity of Amprenavir in Combination with Ritonavir Administered at 600 and 100 Milligrams, Respectively, Every 12 Hours
Antimicrob. Agents Chemother. 2003 47: 3393-3399. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. Gross, R. Bürli, P. Jones, M. Garcia, B. Batiste, J. Kaizerman, H. Moser, V. Jiang, U. Hoch, J.-X. Duan, R. Tanaka, and K. W. Johnson

Pharmacology of Novel Heteroaromatic Polycycle Antibacterials
Antimicrob. Agents Chemother. 2003 47: 3448-3457. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. Pukrittayakamee, S. Wanwimolruk, K. Stepniewska, A. Jantra, S. Huyakorn, S. Looareesuwan, and N. J. White

Quinine Pharmacokinetic-Pharmacodynamic Relationships in Uncomplicated Falciparum Malaria
Antimicrob. Agents Chemother. 2003 47: 3458-3463. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ji-Young Park, Kyoung-Ah Kim, and Su-Lyun Kim

Chloramphenicol Is a Potent Inhibitor of Cytochrome P450 Isoforms CYP2C19 and CYP3A4 in Human Liver Microsomes
Antimicrob. Agents Chemother. 2003 47: 3464-3469. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. A. Zeitlinger, P. Dehghanyar, B. X. Mayer, B. S. Schenk, U. Neckel, G. Heinz, A. Georgopoulos, M. Müller, and C. Joukhadar

Relevance of Soft-Tissue Penetration by Levofloxacin for Target Site Bacterial Killing in Patients with Sepsis
Antimicrob. Agents Chemother. 2003 47: 3548-3553. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marylore Chenel, Anne Limosin, Sandrine Marchand, Joël Paquereau, Olivier Mimoz, and William Couet

Norfloxacin-Induced Electroencephalogram Alteration and Seizures in Rats Are Not Triggered by Enhanced Levels of Intracerebral Glutamate
Antimicrob. Agents Chemother. 2003 47: 3660-3662. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

John Vernachio, Arnold S. Bayer, Thuan Le, Yin-Li Chai, Bradley Prater, Amy Schneider, Brenda Ames, Peter Syribeys, Jeffrey Robbins, and Joseph M. Patti

Anti-Clumping Factor A Immunoglobulin Reduces the Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in an Experimental Model of Infective Endocarditis
Antimicrob. Agents Chemother. 2003 47: 3400-3406. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Eveline Roseeuw, Veerle Coessens, Anne-Marie Balazuc, Micheline Lagranderie, Pierre Chavarot, Augusto Pessina, Maria Grazia Neri, Etienne Schacht, Gilles Marchal, and Dominique Domurado

Synthesis, Degradation, and Antimicrobial Properties of Targeted Macromolecular Prodrugs of Norfloxacin
Antimicrob. Agents Chemother. 2003 47: 3435-3441. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jeff Alder, Tongchaun Li, Donghui Yu, Larry Morton, Jared Silverman, Xi-Xian Zhang, Ian Critchley, and Grace Thorne

Analysis of Daptomycin Efficacy and Breakpoint Standards in a Murine Model of Enterococcus faecalis and Enterococcus faecium Renal Infection
Antimicrob. Agents Chemother. 2003 47: 3561-3566. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Claudia K. Hoyen, Nicole J. Pultz, David L. Paterson, David C. Aron, and Curtis J. Donskey

Effect of Parenteral Antibiotic Administration on Establishment of Intestinal Colonization in Mice by Klebsiella pneumoniae Strains Producing Extended-Spectrum ß-Lactamases
Antimicrob. Agents Chemother. 2003 47: 3610-3612. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Eric Dannaoui, Jacques F. G. M. Meis, David Loebenberg, and Paul E. Verweij

Activity of Posaconazole in Treatment of Experimental Disseminated Zygomycosis
Antimicrob. Agents Chemother. 2003 47: 3647-3650. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laurent Dubé, Jocelyne Caillon, Christèle Gras-Le Guen, Cédric Jacqueline, Marie-France Kergueris, Jean-Claude Granry, Gilles Potel, and Denis Bugnon

Simulation of Human Gentamicin Pharmacokinetics in an Experimental Enterococcus faecalis Endocarditis Model
Antimicrob. Agents Chemother. 2003 47: 3663-3666. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Julie A. Wu, Caroline Kusuma, James J. Mond, and John F. Kokai-Kun

Lysostaphin Disrupts Staphylococcus aureus and Staphylococcus epidermidis Biofilms on Artificial Surfaces
Antimicrob. Agents Chemother. 2003 47: 3407-3414. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Julio A. Vázquez, Luisa Arreaza, Colin Block, Ingrid Ehrhard, Stephen J. Gray, Sigrid Heuberger, Steen Hoffmann, Paula Kriz, Pierre Nicolas, Per Olcen, Anna Skoczynska, Lodewijk Spanjaard, Paola Stefanelli, Muhamed-Kheir Taha, and Georgina Tzanakaki

Interlaboratory Comparison of Agar Dilution and Etest Methods for Determining the MICs of Antibiotics Used in Management of Neisseria meningitidis Infections
Antimicrob. Agents Chemother. 2003 47: 3430-3434. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Andrew J. McBain, Robert G. Bartolo, Carl E. Catrenich, Duane Charbonneau, Ruth G. Ledder, and Peter Gilbert

Effects of Triclosan-Containing Rinse on the Dynamics and Antimicrobial Susceptibility of In Vitro Plaque Ecosystems
Antimicrob. Agents Chemother. 2003 47: 3531-3538. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

María Pérez-Vázquez, Federico Román, Belen Aracil, Rafael Cantón, and José Campos

In Vitro Activities of Garenoxacin (BMS-284756) against Haemophilus influenzae Isolates with Different Fluoroquinolone Susceptibilities
Antimicrob. Agents Chemother. 2003 47: 3539-3541. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Patrick Grohs, Serge Houssaye, Agnès Aubert, Laurent Gutmann, and Emmanuelle Varon

In Vitro Activities of Garenoxacin (BMS-284756) against Streptococcus pneumoniae, Viridans Group Streptococci, and Enterococcus faecalis Compared to Those of Six Other Quinolones
Antimicrob. Agents Chemother. 2003 47: 3542-3547. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Issam Raad, Ioannis Chatzinikolaou, Gassan Chaiban, Hend Hanna, Ray Hachem, Tanya Dvorak, Guy Cook, and William Costerton

In Vitro and Ex Vivo Activities of Minocycline and EDTA against Microorganisms Embedded in Biofilm on Catheter Surfaces
Antimicrob. Agents Chemother. 2003 47: 3580-3585. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John L. Pace, Kevin Krause, Deborah Johnston, Dmitri Debabov, Terry Wu, Lesley Farrington, Cassie Lane, Deborah L. Higgins, Burt Christensen, J. Kevin Judice, and Koné Kaniga

In Vitro Activity of TD-6424 against Staphylococcus aureus
Antimicrob. Agents Chemother. 2003 47: 3602-3604. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christof von Eiff, John F. Kokai-Kun, Karsten Becker, and Georg Peters

In Vitro Activity of Recombinant Lysostaphin against Staphylococcus aureus Isolates from Anterior Nares and Blood
Antimicrob. Agents Chemother. 2003 47: 3613-3615. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anandi Martin, Mirtha Camacho, Françoise Portaels, and Juan Carlos Palomino

Resazurin Microtiter Assay Plate Testing of Mycobacterium tuberculosis Susceptibilities to Second-Line Drugs: Rapid, Simple, and Inexpensive Method
Antimicrob. Agents Chemother. 2003 47: 3616-3619. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rama Ramani, Madhurama Gangwar, and Vishnu Chaturvedi

Flow Cytometry Antifungal Susceptibility Testing of Aspergillus fumigatus and Comparison of Mode of Action of Voriconazole vis-à-vis Amphotericin B and Itraconazole
Antimicrob. Agents Chemother. 2003 47: 3627-3629. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robin A. Howe, Mandy Wootton, Alan R. Noel, Karen E. Bowker, Timothy R. Walsh, and Alasdair P. MacGowan

Activity of AZD2563, a Novel Oxazolidinone, against Staphylococcus aureus Strains with Reduced Susceptibility to Vancomycin or Linezolid
Antimicrob. Agents Chemother. 2003 47: 3651-3652. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F. Patterson, Brian L. Wickes, and José L. López-Ribot

Antifungal Combinations against Candida albicans Biofilms In Vitro
Antimicrob. Agents Chemother. 2003 47: 3657-3659. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. Liebetrau, A. C. Rodloff, J. Behra-Miellet, and L. Dubreuil

In Vitro Activities of a New Des-Fluoro(6) Quinolone, Garenoxacin, against Clinical Anaerobic Bacteria
Antimicrob. Agents Chemother. 2003 47: 3667-3671. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Yu-Hong Min, Jae-Hee Jeong, Yun-Jeong Choi, Hee-Jeong Yun, Kyungwon Lee, Mi-Ja Shim, Jin-Hwan Kwak, and Eung-Chil Choi

Heterogeneity of Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Enterococci
Antimicrob. Agents Chemother. 2003 47: 3415-3420. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Birgitte H. Kallipolitis, Hanne Ingmer, Cormac G. Gahan, Colin Hill, and Lotte Søgaard-Andersen

CesRK, a Two-Component Signal Transduction System in Listeria monocytogenes, Responds to the Presence of Cell Wall-Acting Antibiotics and Affects ß-Lactam Resistance
Antimicrob. Agents Chemother. 2003 47: 3421-3429. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nanhua Chen, Dennis E. Kyle, Cielo Pasay, Elizabeth V. Fowler, Joanne Baker, Jennifer M. Peters, and Qin Cheng

pfcrt Allelic Types with Two Novel Amino Acid Mutations in Chloroquine-Resistant Plasmodium falciparum Isolates from the Philippines
Antimicrob. Agents Chemother. 2003 47: 3500-3505. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Corinne Arpin, Véronique Dubois, Laure Coulange, Catherine André, Isabelle Fischer, Patrick Noury, Frédéric Grobost, Jean-Philippe Brochet, Jacqueline Jullin, Brigitte Dutilh, Gilberte Larribet, Isabelle Lagrange, and Claudine Quentin

Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae in Community and Private Health Care Centers
Antimicrob. Agents Chemother. 2003 47: 3506-3514. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Agnès Lefort, Louis Garry, Florence Depardieu, Patrice Courvalin, and Bruno Fantin

Influence of VanD Type Resistance on Activities of Glycopeptides In Vitro and in Experimental Endocarditis Due to Enterococcus faecium
Antimicrob. Agents Chemother. 2003 47: 3515-3518. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

B. Helen Jost, Adam C. Field, Hien T. Trinh, J. Glenn Songer, and Stephen J. Billington

Tylosin Resistance in Arcanobacterium pyogenes Is Encoded by an Erm X Determinant
Antimicrob. Agents Chemother. 2003 47: 3519-3524. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David L. Paterson, Kristine M. Hujer, Andrea M. Hujer, Bethany Yeiser, Michael D. Bonomo, Louis B. Rice, Robert A. Bonomo, and the International Klebsiella Study Group,

Extended-Spectrum ß-Lactamases in Klebsiella pneumoniae Bloodstream Isolates from Seven Countries: Dominance and Widespread Prevalence of SHV- and CTX-M-Type ß-Lactamases
Antimicrob. Agents Chemother. 2003 47: 3554-3560. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

J. M. Ling, E. W. Chan, A. W. Lam, and A. F. Cheng

Mutations in Topoisomerase Genes of Fluoroquinolone-Resistant Salmonellae in Hong Kong
Antimicrob. Agents Chemother. 2003 47: 3567-3573. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hilmar Wisplinghoff, Adriana E. Rosato, Mark C. Enright, Michael Noto, William Craig, and Gordon L. Archer

Related Clones Containing SCCmec Type IV Predominate among Clinically Significant Staphylococcus epidermidis Isolates
Antimicrob. Agents Chemother. 2003 47: 3574-3579. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Wei Liu, Michail S. Lionakis, Russell E. Lewis, Nathan Wiederhold, Gregory S. May, and Dimitrios P. Kontoyiannis

Attenuation of Itraconazole Fungicidal Activity following Preexposure of Aspergillus fumigatus to Fluconazole
Antimicrob. Agents Chemother. 2003 47: 3592-3597. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christoph Oberparleiter, Lydia Kaiserer, Hubertus Haas, Peter Ladurner, Manfred Andratsch, and Florentine Marx

Active Internalization of the Penicillium chrysogenum Antifungal Protein PAF in Sensitive Aspergilli
Antimicrob. Agents Chemother. 2003 47: 3598-3601. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yoshiaki Kawamura, Hiromitsu Fujiwara, Noriko Mishima, Yuko Tanaka, Ayako Tanimoto, Shiro Ikawa, Youko Itoh, and Takayuki Ezaki

First Streptococcus agalactiae Isolates Highly Resistant to Quinolones, with Point Mutations in gyrA and parC
Antimicrob. Agents Chemother. 2003 47: 3605-3609. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alistair Sinclair, Catherine Arnold, and Neil Woodford

Rapid Detection and Estimation by Pyrosequencing of 23S rRNA Genes with a Single Nucleotide Polymorphism Conferring Linezolid Resistance in Enterococci
Antimicrob. Agents Chemother. 2003 47: 3620-3622. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Colin S. Osborne, Bettina Hofbauer, Bertrand Favre, and Neil S. Ryder

In Vitro Analysis of the Ability of Trichophyton rubrum To Become Resistant to Terbinafine
Antimicrob. Agents Chemother. 2003 47: 3634-3636. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

E. Pérez-Trallero, J. M. Marimón, A. González, C. García-Rey, and L. Aguilar

Genetic Relatedness of Recently Collected Spanish Respiratory Tract Streptococcus pneumoniae Isolates with Reduced Susceptibility to Amoxicillin
Antimicrob. Agents Chemother. 2003 47: 3637-3639. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Angelika Miko, Karin Pries, Andreas Schroeter, and Reiner Helmuth

Multiple-Drug Resistance in D-Tartrate-Positive Salmonella enterica Serovar Paratyphi B Isolates from Poultry Is Mediated by Class 2 Integrons Inserted into the Bacterial Chromosome
Antimicrob. Agents Chemother. 2003 47: 3640-3643. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laura Rodero, Emilia Mellado, A. Carolina Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca-Estrella, Graciela Davel, and Juan L. Rodriguez-Tudela

G484S Amino Acid Substitution in Lanosterol 14- Demethylase (ERG11) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate
Antimicrob. Agents Chemother. 2003 47: 3653-3656. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tsi-Shu Huang, Susan Shin-Jung Lee, Hui-Zin Tu, Wen-Kuei Huang, Yao-Shen Chen, Chung-Kai Huang, Shue-Ren Wann, Hsi-Hsun Lin, and Yung-Ching Liu

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan
Antimicrob. Agents Chemother. 2003 47: 3672-3673. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

G. Zanetti, F. Bally, G. Greub, J. Garbino, T. Kinge, D. Lew, J.-A. Romand, J. Bille, D. Aymon, L. Stratchounski, L. Krawczyk, E. Rubinstein, M.-D. Schaller, R. Chiolero, M.-P. Glauser, A. Cometta, and the Cefepime Study Group,

Cefepime versus Imipenem-Cilastatin for Treatment of Nosocomial Pneumonia in Intensive Care Unit Patients: a Multicenter, Evaluator-Blind, Prospective, Randomized Study
Antimicrob. Agents Chemother. 2003 47: 3442-3447. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Stefan Reuter, Andreas Buck, Olaf Grebe, Karin Nüssle-Kügele, Peter Kern, and Burkhard J. Manfras

Salvage Treatment with Amphotericin B in Progressive Human Alveolar Echinococcosis
Antimicrob. Agents Chemother. 2003 47: 3586-3591. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Philip J. Budge, Jacob Lebowitz, and Barney S. Graham

Antiviral Activity of RhoA-Derived Peptides against Respiratory Syncytial Virus Is Dependent on Formation of Peptide Dimers
Antimicrob. Agents Chemother. 2003 47: 3470-3477. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Katharina Wolf, Hauke Walter, Niko Beerenwinkel, Wilco Keulen, Rolf Kaiser, Daniel Hoffmann, Thomas Lengauer, Joachim Selbig, Anne-Mieke Vandamme, Klaus Korn, and Barbara Schmidt

Tenofovir Resistance and Resensitization
Antimicrob. Agents Chemother. 2003 47: 3478-3484. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tammy T. Nguyen, Adam T. Gates, Lester L. Gutshall, Victor K. Johnston, Baohua Gu, Kevin J. Duffy, and Robert T. Sarisky

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor
Antimicrob. Agents Chemother. 2003 47: 3525-3530. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Bernard Masquelier, Cecile Droz, Martin Dary, Christian Perronne, Virginie Ferré, Bruno Spire, Diane Descamps, François Raffi, Françoise Brun-Vézinet, Geneviève Chêne, and the APROCO/COPILOTE Study Group

R57K Polymorphism in the Human Immunodeficiency Virus Type 1 Protease as Predictor of Early Virological Failure in a Cohort of Antiretroviral-Naive Patients Treated Mostly with a Nelfinavir-Containing Regimen
Antimicrob. Agents Chemother. 2003 47: 3623-3626. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Cécile L. Tremblay, Danielle L. Poulin, Jennifer L. Hicks, Subajini Selliah, Annie Chamberland, Françoise Giguel, Christopher S. Kollmann, Ting Chao Chou, Huajin Dong, and Martin S. Hirsch

Favorable Interactions between Enfuvirtide and 1-ß-D-2,6-Diaminopurine Dioxolane In Vitro
Antimicrob. Agents Chemother. 2003 47: 3644-3646. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Guozhu Chen, Cheryl L. Patten, and Herb E. Schellhorn

Controlled Expression of an rpoS Antisense RNA Can Inhibit RpoS Function in Escherichia coli
Antimicrob. Agents Chemother. 2003 47: 3485-3493. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. Ramharter, H. Noedl, H. Winkler, W. Graninger, W. H. Wernsdorfer, P. G. Kremsner, and S. Winkler

In Vitro Activity and Interaction of Clindamycin Combined with Dihydroartemisinin against Plasmodium falciparum
Antimicrob. Agents Chemother. 2003 47: 3494-3499. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Teresa Krakauer and Marilyn Buckley

Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines
Antimicrob. Agents Chemother. 2003 47: 3630-3633. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.