Contents: November 2003, Volume 47, Issue 11        Minireviews        Pharmacology        Experimental Therapeutics        Susceptibility        Mechanisms of Resistance        Clinical Therapeutics        Antiviral Agents        Mechanisms of Action        Biologic Response Modifiers Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Molecular Impact of the M184V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Karidia Diallo, Matthias Götte, and M. A. Wainberg Antimicrob. Agents Chemother. November 2003 47: 3377-3383; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments Reine Note, Caroline Maisonneuve, Philippe Lettéron, Gilles Peytavin, Fatima Djouadi, Anissa Igoudjil, Marie-Christine Guimont, Michel Biour, Dominique Pessayre, and Bernard Fromenty Antimicrob. Agents Chemother. November 2003 47: 3384-3392; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro-In Vivo Model for Evaluating the Antiviral Activity of Amprenavir in Combination with Ritonavir Administered at 600 and 100 Milligrams, Respectively, Every 12 Hours Sandra L. Preston, Peter J. Piliero, John A. Bilello, Daniel S. Stein, William T. Symonds, and George L. Drusano Antimicrob. Agents Chemother. November 2003 47: 3393-3399; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology of Novel Heteroaromatic Polycycle Antibacterials M. Gross, R. Bürli, P. Jones, M. Garcia, B. Batiste, J. Kaizerman, H. Moser, V. Jiang, U. Hoch, J.-X. Duan, R. Tanaka, and K. W. Johnson Antimicrob. Agents Chemother. November 2003 47: 3448-3457; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinine Pharmacokinetic-Pharmacodynamic Relationships in Uncomplicated Falciparum Malaria S. Pukrittayakamee, S. Wanwimolruk, K. Stepniewska, A. Jantra, S. Huyakorn, S. Looareesuwan, and N. J. White Antimicrob. Agents Chemother. November 2003 47: 3458-3463; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chloramphenicol Is a Potent Inhibitor of Cytochrome P450 Isoforms CYP2C19 and CYP3A4 in Human Liver Microsomes Ji-Young Park, Kyoung-Ah Kim, and Su-Lyun Kim Antimicrob. Agents Chemother. November 2003 47: 3464-3469; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relevance of Soft-Tissue Penetration by Levofloxacin for Target Site Bacterial Killing in Patients with Sepsis M. A. Zeitlinger, P. Dehghanyar, B. X. Mayer, B. S. Schenk, U. Neckel, G. Heinz, A. Georgopoulos, M. Müller, and C. Joukhadar Antimicrob. Agents Chemother. November 2003 47: 3548-3553; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Norfloxacin-Induced Electroencephalogram Alteration and Seizures in Rats Are Not Triggered by Enhanced Levels of Intracerebral Glutamate Marylore Chenel, Anne Limosin, Sandrine Marchand, Joël Paquereau, Olivier Mimoz, and William Couet Antimicrob. Agents Chemother. November 2003 47: 3660-3662; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Anti-Clumping Factor A Immunoglobulin Reduces the Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in an Experimental Model of Infective Endocarditis John Vernachio, Arnold S. Bayer, Thuan Le, Yin-Li Chai, Bradley Prater, Amy Schneider, Brenda Ames, Peter Syribeys, Jeffrey Robbins, and Joseph M. Patti Antimicrob. Agents Chemother. November 2003 47: 3400-3406; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synthesis, Degradation, and Antimicrobial Properties of Targeted Macromolecular Prodrugs of Norfloxacin Eveline Roseeuw, Veerle Coessens, Anne-Marie Balazuc, Micheline Lagranderie, Pierre Chavarot, Augusto Pessina, Maria Grazia Neri, Etienne Schacht, Gilles Marchal, and Dominique Domurado Antimicrob. Agents Chemother. November 2003 47: 3435-3441; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of Daptomycin Efficacy and Breakpoint Standards in a Murine Model of Enterococcus faecalis and Enterococcus faecium Renal Infection Jeff Alder, Tongchaun Li, Donghui Yu, Larry Morton, Jared Silverman, Xi-Xian Zhang, Ian Critchley, and Grace Thorne Antimicrob. Agents Chemother. November 2003 47: 3561-3566; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Parenteral Antibiotic Administration on Establishment of Intestinal Colonization in Mice by Klebsiella pneumoniae Strains Producing Extended-Spectrum ß-Lactamases Claudia K. Hoyen, Nicole J. Pultz, David L. Paterson, David C. Aron, and Curtis J. Donskey Antimicrob. Agents Chemother. November 2003 47: 3610-3612; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Posaconazole in Treatment of Experimental Disseminated Zygomycosis Eric Dannaoui, Jacques F. G. M. Meis, David Loebenberg, and Paul E. Verweij Antimicrob. Agents Chemother. November 2003 47: 3647-3650; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Simulation of Human Gentamicin Pharmacokinetics in an Experimental Enterococcus faecalis Endocarditis Model Laurent Dubé, Jocelyne Caillon, Christèle Gras-Le Guen, Cédric Jacqueline, Marie-France Kergueris, Jean-Claude Granry, Gilles Potel, and Denis Bugnon Antimicrob. Agents Chemother. November 2003 47: 3663-3666; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Lysostaphin Disrupts Staphylococcus aureus and Staphylococcus epidermidis Biofilms on Artificial Surfaces Julie A. Wu, Caroline Kusuma, James J. Mond, and John F. Kokai-Kun Antimicrob. Agents Chemother. November 2003 47: 3407-3414; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interlaboratory Comparison of Agar Dilution and Etest Methods for Determining the MICs of Antibiotics Used in Management of Neisseria meningitidis Infections Julio A. Vázquez, Luisa Arreaza, Colin Block, Ingrid Ehrhard, Stephen J. Gray, Sigrid Heuberger, Steen Hoffmann, Paula Kriz, Pierre Nicolas, Per Olcen, Anna Skoczynska, Lodewijk Spanjaard, Paola Stefanelli, Muhamed-Kheir Taha, and Georgina Tzanakaki Antimicrob. Agents Chemother. November 2003 47: 3430-3434; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Triclosan-Containing Rinse on the Dynamics and Antimicrobial Susceptibility of In Vitro Plaque Ecosystems Andrew J. McBain, Robert G. Bartolo, Carl E. Catrenich, Duane Charbonneau, Ruth G. Ledder, and Peter Gilbert Antimicrob. Agents Chemother. November 2003 47: 3531-3538; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Garenoxacin (BMS-284756) against Haemophilus influenzae Isolates with Different Fluoroquinolone Susceptibilities María Pérez-Vázquez, Federico Román, Belen Aracil, Rafael Cantón, and José Campos Antimicrob. Agents Chemother. November 2003 47: 3539-3541; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Garenoxacin (BMS-284756) against Streptococcus pneumoniae, Viridans Group Streptococci, and Enterococcus faecalis Compared to Those of Six Other Quinolones Patrick Grohs, Serge Houssaye, Agnès Aubert, Laurent Gutmann, and Emmanuelle Varon Antimicrob. Agents Chemother. November 2003 47: 3542-3547; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and Ex Vivo Activities of Minocycline and EDTA against Microorganisms Embedded in Biofilm on Catheter Surfaces Issam Raad, Ioannis Chatzinikolaou, Gassan Chaiban, Hend Hanna, Ray Hachem, Tanya Dvorak, Guy Cook, and William Costerton Antimicrob. Agents Chemother. November 2003 47: 3580-3585; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of TD-6424 against Staphylococcus aureus John L. Pace, Kevin Krause, Deborah Johnston, Dmitri Debabov, Terry Wu, Lesley Farrington, Cassie Lane, Deborah L. Higgins, Burt Christensen, J. Kevin Judice, and Koné Kaniga Antimicrob. Agents Chemother. November 2003 47: 3602-3604; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Recombinant Lysostaphin against Staphylococcus aureus Isolates from Anterior Nares and Blood Christof von Eiff, John F. Kokai-Kun, Karsten Becker, and Georg Peters Antimicrob. Agents Chemother. November 2003 47: 3613-3615; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resazurin Microtiter Assay Plate Testing of Mycobacterium tuberculosis Susceptibilities to Second-Line Drugs: Rapid, Simple, and Inexpensive Method Anandi Martin, Mirtha Camacho, Françoise Portaels, and Juan Carlos Palomino Antimicrob. Agents Chemother. November 2003 47: 3616-3619; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Flow Cytometry Antifungal Susceptibility Testing of Aspergillus fumigatus and Comparison of Mode of Action of Voriconazole vis-à-vis Amphotericin B and Itraconazole Rama Ramani, Madhurama Gangwar, and Vishnu Chaturvedi Antimicrob. Agents Chemother. November 2003 47: 3627-3629; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of AZD2563, a Novel Oxazolidinone, against Staphylococcus aureus Strains with Reduced Susceptibility to Vancomycin or Linezolid Robin A. Howe, Mandy Wootton, Alan R. Noel, Karen E. Bowker, Timothy R. Walsh, and Alasdair P. MacGowan Antimicrob. Agents Chemother. November 2003 47: 3651-3652; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Combinations against Candida albicans Biofilms In Vitro Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F. Patterson, Brian L. Wickes, and José L. López-Ribot Antimicrob. Agents Chemother. November 2003 47: 3657-3659; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of a New Des-Fluoro(6) Quinolone, Garenoxacin, against Clinical Anaerobic Bacteria A. Liebetrau, A. C. Rodloff, J. Behra-Miellet, and L. Dubreuil Antimicrob. Agents Chemother. November 2003 47: 3667-3671; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Heterogeneity of Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Enterococci Yu-Hong Min, Jae-Hee Jeong, Yun-Jeong Choi, Hee-Jeong Yun, Kyungwon Lee, Mi-Ja Shim, Jin-Hwan Kwak, and Eung-Chil Choi Antimicrob. Agents Chemother. November 2003 47: 3415-3420; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CesRK, a Two-Component Signal Transduction System in Listeria monocytogenes, Responds to the Presence of Cell Wall-Acting Antibiotics and Affects ß-Lactam Resistance Birgitte H. Kallipolitis, Hanne Ingmer, Cormac G. Gahan, Colin Hill, and Lotte Søgaard-Andersen Antimicrob. Agents Chemother. November 2003 47: 3421-3429; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

pfcrt Allelic Types with Two Novel Amino Acid Mutations in Chloroquine-Resistant Plasmodium falciparum Isolates from the Philippines Nanhua Chen, Dennis E. Kyle, Cielo Pasay, Elizabeth V. Fowler, Joanne Baker, Jennifer M. Peters, and Qin Cheng Antimicrob. Agents Chemother. November 2003 47: 3500-3505; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae in Community and Private Health Care Centers Corinne Arpin, Véronique Dubois, Laure Coulange, Catherine André, Isabelle Fischer, Patrick Noury, Frédéric Grobost, Jean-Philippe Brochet, Jacqueline Jullin, Brigitte Dutilh, Gilberte Larribet, Isabelle Lagrange, and Claudine Quentin Antimicrob. Agents Chemother. November 2003 47: 3506-3514; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of VanD Type Resistance on Activities of Glycopeptides In Vitro and in Experimental Endocarditis Due to Enterococcus faecium Agnès Lefort, Louis Garry, Florence Depardieu, Patrice Courvalin, and Bruno Fantin Antimicrob. Agents Chemother. November 2003 47: 3515-3518; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tylosin Resistance in Arcanobacterium pyogenes Is Encoded by an Erm X Determinant B. Helen Jost, Adam C. Field, Hien T. Trinh, J. Glenn Songer, and Stephen J. Billington Antimicrob. Agents Chemother. November 2003 47: 3519-3524; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum ß-Lactamases in Klebsiella pneumoniae Bloodstream Isolates from Seven Countries: Dominance and Widespread Prevalence of SHV- and CTX-M-Type ß-Lactamases David L. Paterson, Kristine M. Hujer, Andrea M. Hujer, Bethany Yeiser, Michael D. Bonomo, Louis B. Rice, Robert A. Bonomo, and the International Klebsiella Study Group, Antimicrob. Agents Chemother. November 2003 47: 3554-3560; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Topoisomerase Genes of Fluoroquinolone-Resistant Salmonellae in Hong Kong J. M. Ling, E. W. Chan, A. W. Lam, and A. F. Cheng Antimicrob. Agents Chemother. November 2003 47: 3567-3573; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Related Clones Containing SCCmec Type IV Predominate among Clinically Significant Staphylococcus epidermidis Isolates Hilmar Wisplinghoff, Adriana E. Rosato, Mark C. Enright, Michael Noto, William Craig, and Gordon L. Archer Antimicrob. Agents Chemother. November 2003 47: 3574-3579; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Attenuation of Itraconazole Fungicidal Activity following Preexposure of Aspergillus fumigatus to Fluconazole Wei Liu, Michail S. Lionakis, Russell E. Lewis, Nathan Wiederhold, Gregory S. May, and Dimitrios P. Kontoyiannis Antimicrob. Agents Chemother. November 2003 47: 3592-3597; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Active Internalization of the Penicillium chrysogenum Antifungal Protein PAF in Sensitive Aspergilli Christoph Oberparleiter, Lydia Kaiserer, Hubertus Haas, Peter Ladurner, Manfred Andratsch, and Florentine Marx Antimicrob. Agents Chemother. November 2003 47: 3598-3601; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Streptococcus agalactiae Isolates Highly Resistant to Quinolones, with Point Mutations in gyrA and parC Yoshiaki Kawamura, Hiromitsu Fujiwara, Noriko Mishima, Yuko Tanaka, Ayako Tanimoto, Shiro Ikawa, Youko Itoh, and Takayuki Ezaki Antimicrob. Agents Chemother. November 2003 47: 3605-3609; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Detection and Estimation by Pyrosequencing of 23S rRNA Genes with a Single Nucleotide Polymorphism Conferring Linezolid Resistance in Enterococci Alistair Sinclair, Catherine Arnold, and Neil Woodford Antimicrob. Agents Chemother. November 2003 47: 3620-3622; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Analysis of the Ability of Trichophyton rubrum To Become Resistant to Terbinafine Colin S. Osborne, Bettina Hofbauer, Bertrand Favre, and Neil S. Ryder Antimicrob. Agents Chemother. November 2003 47: 3634-3636; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Relatedness of Recently Collected Spanish Respiratory Tract Streptococcus pneumoniae Isolates with Reduced Susceptibility to Amoxicillin E. Pérez-Trallero, J. M. Marimón, A. González, C. García-Rey, and L. Aguilar Antimicrob. Agents Chemother. November 2003 47: 3637-3639; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple-Drug Resistance in D-Tartrate-Positive Salmonella enterica Serovar Paratyphi B Isolates from Poultry Is Mediated by Class 2 Integrons Inserted into the Bacterial Chromosome Angelika Miko, Karin Pries, Andreas Schroeter, and Reiner Helmuth Antimicrob. Agents Chemother. November 2003 47: 3640-3643; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

G484S Amino Acid Substitution in Lanosterol 14- Demethylase (ERG11) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate Laura Rodero, Emilia Mellado, A. Carolina Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca-Estrella, Graciela Davel, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. November 2003 47: 3653-3656; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan Tsi-Shu Huang, Susan Shin-Jung Lee, Hui-Zin Tu, Wen-Kuei Huang, Yao-Shen Chen, Chung-Kai Huang, Shue-Ren Wann, Hsi-Hsun Lin, and Yung-Ching Liu Antimicrob. Agents Chemother. November 2003 47: 3672-3673; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Cefepime versus Imipenem-Cilastatin for Treatment of Nosocomial Pneumonia in Intensive Care Unit Patients: a Multicenter, Evaluator-Blind, Prospective, Randomized Study G. Zanetti, F. Bally, G. Greub, J. Garbino, T. Kinge, D. Lew, J.-A. Romand, J. Bille, D. Aymon, L. Stratchounski, L. Krawczyk, E. Rubinstein, M.-D. Schaller, R. Chiolero, M.-P. Glauser, A. Cometta, and the Cefepime Study Group, Antimicrob. Agents Chemother. November 2003 47: 3442-3447; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Salvage Treatment with Amphotericin B in Progressive Human Alveolar Echinococcosis Stefan Reuter, Andreas Buck, Olaf Grebe, Karin Nüssle-Kügele, Peter Kern, and Burkhard J. Manfras Antimicrob. Agents Chemother. November 2003 47: 3586-3591; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Antiviral Activity of RhoA-Derived Peptides against Respiratory Syncytial Virus Is Dependent on Formation of Peptide Dimers Philip J. Budge, Jacob Lebowitz, and Barney S. Graham Antimicrob. Agents Chemother. November 2003 47: 3470-3477; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tenofovir Resistance and Resensitization Katharina Wolf, Hauke Walter, Niko Beerenwinkel, Wilco Keulen, Rolf Kaiser, Daniel Hoffmann, Thomas Lengauer, Joachim Selbig, Anne-Mieke Vandamme, Klaus Korn, and Barbara Schmidt Antimicrob. Agents Chemother. November 2003 47: 3478-3484; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor Tammy T. Nguyen, Adam T. Gates, Lester L. Gutshall, Victor K. Johnston, Baohua Gu, Kevin J. Duffy, and Robert T. Sarisky Antimicrob. Agents Chemother. November 2003 47: 3525-3530; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

R57K Polymorphism in the Human Immunodeficiency Virus Type 1 Protease as Predictor of Early Virological Failure in a Cohort of Antiretroviral-Naive Patients Treated Mostly with a Nelfinavir-Containing Regimen Bernard Masquelier, Cecile Droz, Martin Dary, Christian Perronne, Virginie Ferré, Bruno Spire, Diane Descamps, François Raffi, Françoise Brun-Vézinet, Geneviève Chêne, and the APROCO/COPILOTE Study Group Antimicrob. Agents Chemother. November 2003 47: 3623-3626; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Favorable Interactions between Enfuvirtide and 1-ß-D-2,6-Diaminopurine Dioxolane In Vitro Cécile L. Tremblay, Danielle L. Poulin, Jennifer L. Hicks, Subajini Selliah, Annie Chamberland, Françoise Giguel, Christopher S. Kollmann, Ting Chao Chou, Huajin Dong, and Martin S. Hirsch Antimicrob. Agents Chemother. November 2003 47: 3644-3646; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Controlled Expression of an rpoS Antisense RNA Can Inhibit RpoS Function in Escherichia coli Guozhu Chen, Cheryl L. Patten, and Herb E. Schellhorn Antimicrob. Agents Chemother. November 2003 47: 3485-3493; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity and Interaction of Clindamycin Combined with Dihydroartemisinin against Plasmodium falciparum M. Ramharter, H. Noedl, H. Winkler, W. Graninger, W. H. Wernsdorfer, P. G. Kremsner, and S. Winkler Antimicrob. Agents Chemother. November 2003 47: 3494-3499; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines Teresa Krakauer and Marilyn Buckley Antimicrob. Agents Chemother. November 2003 47: 3630-3633; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.