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Chemistry; Biosynthesis:

E. Heinzelmann, S. Berger, O. Puk, B. Reichenstein, W. Wohlleben, and D. Schwartz

A Glutamate Mutase Is Involved in the Biosynthesis of the Lipopeptide Antibiotic Friulimicin in Actinoplanes friuliensis
Antimicrob. Agents Chemother. 2003 47: 447-457. [Abstract] [Full Text] [PDF]  

Susceptibility:

Brunello Oliva, Keith Miller, Nico Caggiano, Alexander J. O'Neill, Gregory D. Cuny, Michael Z. Hoemann, James R. Hauske, and Ian Chopra

Biological Properties of Novel Antistaphylococcal Quinoline-Indole Agents
Antimicrob. Agents Chemother. 2003 47: 458-466. [Abstract] [Full Text] [PDF]  

Marianne Stettler, Renate Fink, Mirjam Walker, Bruno Gottstein, Timothy G. Geary, Jean François Rossignol, and Andrew Hemphill

In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
Antimicrob. Agents Chemother. 2003 47: 467-474. [Abstract] [Full Text] [PDF]  

Wesley C. Van Voorhis, Lynn K. Barrett, Richard T. Eastman, Ryan Alfonso, and Kent Dupuis

Trypanosoma cruzi Inactivation in Human Platelet Concentrates and Plasma by a Psoralen (Amotosalen HCl) and Long-Wavelength UV
Antimicrob. Agents Chemother. 2003 47: 475-479. [Abstract] [Full Text] [PDF]  

Alim Isnansetyo and Yuto Kamei

MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30^T, against Methicillin-Resistant Staphylococcus aureus
Antimicrob. Agents Chemother. 2003 47: 480-488. [Abstract] [Full Text] [PDF]  

Ralf René Reinert, Rudolf Lütticken, André Bryskier, and Adnan Al-Lahham

Macrolide-Resistant Streptococcus pneumoniae and Streptococcus pyogenes in the Pediatric Population in Germany during 2000-2001
Antimicrob. Agents Chemother. 2003 47: 489-493. [Abstract] [Full Text] [PDF]  

Thomas Jacobs, Heike Bruhn, Iris Gaworski, Bernhard Fleischer, and Matthias Leippe

NK-Lysin and Its Shortened Analog NK-2 Exhibit Potent Activities against Trypanosoma cruzi
Antimicrob. Agents Chemother. 2003 47: 607-613. [Abstract] [Full Text] [PDF]  

Jean-Marc Rolain, Max Maurin, Marie-Noëlle Mallet, Daniel Parzy, and Didier Raoult

Culture and Antibiotic Susceptibility of Bartonella quintana in Human Erythrocytes
Antimicrob. Agents Chemother. 2003 47: 614-619. [Abstract] [Full Text] [PDF]  

Stefan Reuter, Marion Merkle, Klaus Brehm, Peter Kern, and Burkhard Manfras

Effect of Amphotericin B on Larval Growth of Echinococcus multilocularis
Antimicrob. Agents Chemother. 2003 47: 620-625. [Abstract] [Full Text] [PDF]  

R. J. Suchland, W. M. Geisler, and Walter E. Stamm

Methodologies and Cell Lines Used for Antimicrobial Susceptibility Testing of Chlamydia spp.
Antimicrob. Agents Chemother. 2003 47: 636-642. [Abstract] [Full Text] [PDF]  

Akiko Nagai, Naoaki Yokoyama, Tomohide Matsuo, Sabine Bork, Haruyuki Hirata, Xuenan Xuan, Yinchang Zhu, Florencia G. Claveria, Kozo Fujisaki, and Ikuo Igarashi

Growth-Inhibitory Effects of Artesunate, Pyrimethamine, and Pamaquine against Babesia equi and Babesia caballi in In Vitro Cultures
Antimicrob. Agents Chemother. 2003 47: 800-803. [Abstract] [Full Text] [PDF]  

Kimberly A. Nichol, George G. Zhanel, and Daryl J. Hoban

Molecular Epidemiology of Penicillin-Resistant and Ciprofloxacin-Resistant Streptococcus pneumoniae in Canada
Antimicrob. Agents Chemother. 2003 47: 804-808. [Abstract] [Full Text] [PDF]  

Giovanni Pietro Gesu, Federico Marchetti, Laura Piccoli, and Annalisa Cavallero

Levofloxacin and Ciprofloxacin In Vitro Activities against 4,003 Clinical Bacterial Isolates Collected in 24 Italian Laboratories
Antimicrob. Agents Chemother. 2003 47: 816-819. [Abstract] [Full Text] [PDF]  

Nadjia Ramdani-Bouguessa and Kheira Rahal

Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolated in Algiers, Algeria
Antimicrob. Agents Chemother. 2003 47: 824-826. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Sara Sinha, Natalia Cheshenko, Robert I. Lehrer, and Betsy C. Herold

NP-1, a Rabbit -Defensin, Prevents the Entry and Intercellular Spread of Herpes Simplex Virus Type 2
Antimicrob. Agents Chemother. 2003 47: 494-500. [Abstract] [Full Text] [PDF]  

Martin E. Adelson, Annmarie L. Pacchia, Malvika Kaul, Robert F. Rando, Yacov Ron, Stuart W. Peltz, and Joseph P. Dougherty

Toward the Development of a Virus-Cell-Based Assay for the Discovery of Novel Compounds against Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2003 47: 501-508. [Abstract] [Full Text] [PDF]  

Cristina Pastore, Gastón R. Picchio, Francesco Galimi, Richard Fish, Oliver Hartley, Robin E. Offord, and Donald E. Mosier

Two Mechanisms for Human Immunodeficiency Virus Type 1 Inhibition by N-Terminal Modifications of RANTES
Antimicrob. Agents Chemother. 2003 47: 509-517. [Abstract] [Full Text] [PDF]  

Anne-Geneviève Marcelin, Claire Lamotte, Constance Delaugerre, Nadine Ktorza, Hocine Ait Mohand, Raquel Cacace, Manuela Bonmarchand, Marc Wirden, Anne Simon, Philippe Bossi, François Bricaire, Dominique Costagliola, Christine Katlama, Gilles Peytavin, and Vincent Calvez

Genotypic Inhibitory Quotient as Predictor of Virological Response to Ritonavir-Amprenavir in Human Immunodeficiency Virus Type 1 Protease Inhibitor-Experienced Patients
Antimicrob. Agents Chemother. 2003 47: 594-600. [Abstract] [Full Text] [PDF]  

Yudong Quan, Bluma G. Brenner, Maureen Oliveira, and Mark A. Wainberg

Lamivudine Can Exert a Modest Antiviral Effect against Human Immunodeficiency Virus Type 1 Containing the M184V Mutation
Antimicrob. Agents Chemother. 2003 47: 747-754. [Abstract] [Full Text] [PDF]  

Terri Watkins, Wolfgang Resch, David Irlbeck, and Ronald Swanstrom

Selection of High-Level Resistance to Human Immunodeficiency Virus Type 1 Protease Inhibitors
Antimicrob. Agents Chemother. 2003 47: 759-769. [Abstract] [Full Text] [PDF]  

Pieter Leyssen, Christian Drosten, Marcus Paning, Nathalie Charlier, Jan Paeshuyse, Erik De Clercq, and Johan Neyts

Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice
Antimicrob. Agents Chemother. 2003 47: 777-782. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Inga Odenholt, Ingegerd Gustafsson, Elisabeth Löwdin, and Otto Cars

Suboptimal Antibiotic Dosage as a Risk Factor for Selection of Penicillin-Resistant Streptococcus pneumoniae: In Vitro Kinetic Model
Antimicrob. Agents Chemother. 2003 47: 518-523. [Abstract] [Full Text] [PDF]  

Shannon M. Goswick and George M. Brenner

Activities of Azithromycin and Amphotericin B against Naegleria fowleri In Vitro and in a Mouse Model of Primary Amebic Meningoencephalitis
Antimicrob. Agents Chemother. 2003 47: 524-528. [Abstract] [Full Text] [PDF]  

Esteban C. Nannini, Suresh R. Pai, Kavindra V. Singh, and Barbara E. Murray

Activity of Tigecycline (GAR-936), a Novel Glycylcycline, against Enterococci in the Mouse Peritonitis Model
Antimicrob. Agents Chemother. 2003 47: 529-532. [Abstract] [Full Text] [PDF]  

Paul H. Edelstein, William J. Weiss, and Martha A. C. Edelstein

Activities of Tigecycline (GAR-936) against Legionella pneumophila In Vitro and in Guinea Pigs with L. pneumophila Pneumonia
Antimicrob. Agents Chemother. 2003 47: 533-540. [Abstract] [Full Text] [PDF]  

Yasuki Kamai, Mikie Kubota, Takashi Fukuoka, Yoko Kamai, Naoyuki Maeda, Tsunemichi Hosokawa, Takahiro Shibayama, Katsuhisa Uchida, Hideyo Yamaguchi, and Shogo Kuwahara

Efficacy of CS-758, a Novel Triazole, against Experimental Fluconazole-Resistant Oropharyngeal Candidiasis in Mice
Antimicrob. Agents Chemother. 2003 47: 601-606. [Abstract] [Full Text] [PDF]  

F. Shojaee Aliabadi, M. F. Landoni, and P. Lees

Pharmacokinetics (PK), Pharmacodynamics (PD), and PK-PD Integration of Danofloxacin in Sheep Biological Fluids
Antimicrob. Agents Chemother. 2003 47: 626-635. [Abstract] [Full Text] [PDF]  

Holly L. Hoffman, Michael E. Klepser, Erika J. Ernst, C. Rosemarie Petzold, Loai Mohammed Sa'adah, and Gary V. Doern

Influence of Macrolide Susceptibility on Efficacies of Clarithromycin and Azithromycin against Streptococcus pneumoniae in a Murine Lung Infection Model
Antimicrob. Agents Chemother. 2003 47: 739-746. [Abstract] [Full Text] [PDF]  

Livia Ferrari, Laura Iavarone, Simone Braggio, and Enza Di Modugno

In Vitro and In Vivo Pharmacokinetics-Pharmacodynamics of GV143253A, a Novel Trinem
Antimicrob. Agents Chemother. 2003 47: 770-776. [Abstract] [Full Text] [PDF]  

Anne J. M. Lenaerts, Veronica Gruppo, Jason V. Brooks, and Ian M. Orme

Rapid In Vivo Screening of Experimental Drugs for Tuberculosis Using Gamma Interferon Gene-Disrupted Mice
Antimicrob. Agents Chemother. 2003 47: 783-785. [Abstract] [Full Text] [PDF]  

Tom M. Chiller, Raymond A. Sobel, Javier Capilla Luque, Karl V. Clemons, and David A. Stevens

Efficacy of Amphotericin B or Itraconazole in a Murine Model of Central Nervous System Aspergillus Infection
Antimicrob. Agents Chemother. 2003 47: 813-815. [Abstract] [Full Text] [PDF]  

Pharmacology:

Alexander A. Vinks, Jan G. den Hollander, Shelley E. Overbeek, Roger W. Jelliffe, and Johan W. Mouton

Population Pharmacokinetic Analysis of Nonlinear Behavior of Piperacillin during Intermittent or Continuous Infusion in Patients with Cystic Fibrosis
Antimicrob. Agents Chemother. 2003 47: 541-547. [Abstract] [Full Text] [PDF]  

Alison K. Meagher, Alan Forrest, Craig R. Rayner, Mary C. Birmingham, and Jerome J. Schentag

Population Pharmacokinetics of Linezolid in Patients Treated in a Compassionate-Use Program
Antimicrob. Agents Chemother. 2003 47: 548-553. [Abstract] [Full Text] [PDF]  

Scott Walsh, Anjali Shah, and James Mond

Improved Pharmacokinetics and Reduced Antibody Reactivity of Lysostaphin Conjugated to Polyethylene Glycol
Antimicrob. Agents Chemother. 2003 47: 554-558. [Abstract] [Full Text] [PDF]  

Christopher S. Lepsy, Robert J. Guttendorf, Alan R. Kugler, and David E. Smith

Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney
Antimicrob. Agents Chemother. 2003 47: 689-696. [Abstract] [Full Text] [PDF]  

M. Rebuelto, L. Ambros, and M. Rubio

Daily Variations in Ceftriaxone Pharmacokinetics in Rats
Antimicrob. Agents Chemother. 2003 47: 809-812. [Abstract] [Full Text] [PDF]  

Jianzhong Liu, Ki-Fai Fung, Zhangliu Chen, Zhenling Zeng, and Jie Zhang

Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae
Antimicrob. Agents Chemother. 2003 47: 820-823. [Abstract] [Full Text] [PDF]  

Mechanisms of Resistance:

George A. Jacoby, Nancy Chow, and Ken B. Waites

Prevalence of Plasmid-Mediated Quinolone Resistance
Antimicrob. Agents Chemother. 2003 47: 559-562. [Abstract] [Full Text] [PDF]  

Lin-Hui Su, Cheng-Hsun Chiu, Chishih Chu, Mei-Hui Wang, Ju-Hsin Chia, and Tsu-Lan Wu

In Vivo Acquisition of Ceftriaxone Resistance in Salmonella enterica Serotype Anatum
Antimicrob. Agents Chemother. 2003 47: 563-567. [Abstract] [Full Text] [PDF]  

Andrea Reipert, Kerstin Ehlert, Thomas Kast, and Gabriele Bierbaum

Morphological and Genetic Differences in Two Isogenic Staphylococcus aureus Strains with Decreased Susceptibilities to Vancomycin
Antimicrob. Agents Chemother. 2003 47: 568-576. [Abstract] [Full Text] [PDF]  

Paul A. Mann, Raulo M. Parmegiani, Shui-Qing Wei, Cara A. Mendrick, Xin Li, David Loebenberg, Beth DiDomenico, Roberta S. Hare, Scott S. Walker, and Paul M. McNicholas

Mutations in Aspergillus fumigatus Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14-Demethylase
Antimicrob. Agents Chemother. 2003 47: 577-581. [Abstract] [Full Text] [PDF]  

Tanya A. Murphy, Alan M. Simm, Mark A. Toleman, Ronald N. Jones, and Timothy R. Walsh

Biochemical Characterization of the Acquired Metallo-ß-Lactamase SPM-1 from Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2003 47: 582-587. [Abstract] [Full Text] [PDF]  

Melissa A. Visalli, Ellen Murphy, Steven J. Projan, and Patricia A. Bradford

AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis
Antimicrob. Agents Chemother. 2003 47: 665-669. [Abstract] [Full Text] [PDF]  

Chih-Jen Wei, Benfang Lei, James M. Musser, and Shiao-Chun Tu

Isoniazid Activation Defects in Recombinant Mycobacterium tuberculosis Catalase-Peroxidase (KatG) Mutants Evident in InhA Inhibitor Production
Antimicrob. Agents Chemother. 2003 47: 670-675. [Abstract] [Full Text] [PDF]  

Alexandra S. Blackburn and Simon V. Avery

Genome-Wide Screening of Saccharomyces cerevisiae To Identify Genes Required for Antibiotic Insusceptibility of Eukaryotes
Antimicrob. Agents Chemother. 2003 47: 676-681. [Abstract] [Full Text] [PDF]  

Asunción Seoane, Emilia Sánchez, and Juan M. García-Lobo

Tandem Amplification of a 28-Kilobase Region from the Yersinia enterocolitica Chromosome Containing the blaA Gene
Antimicrob. Agents Chemother. 2003 47: 682-688. [Abstract] [Full Text] [PDF]  

Isabelle Casin, Beatrice Hanau-Berçot, Isabelle Podglajen, Haluk Vahaboglu, and Ekkehard Collatz

Salmonella enterica Serovar Typhimurium bla_PER-1-Carrying Plasmid pSTI1 Encodes an Extended-Spectrum Aminoglycoside 6'-N-Acetyltransferase of Type Ib
Antimicrob. Agents Chemother. 2003 47: 697-703. [Abstract] [Full Text] [PDF]  

Sylvain Godreuil, Marc Galimand, Guy Gerbaud, Christine Jacquet, and Patrice Courvalin

Efflux Pump Lde Is Associated with Fluoroquinolone Resistance in Listeria monocytogenes
Antimicrob. Agents Chemother. 2003 47: 704-708. [Abstract] [Full Text] [PDF]  

Pedro V. L. Cravo, Jane M.-R. Carlton, Paul Hunt, Laura Bisoni, Rose Ann Padua, and David Walliker

Genetics of Mefloquine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi
Antimicrob. Agents Chemother. 2003 47: 709-718. [Abstract] [Full Text] [PDF]  

Glenn W. Kaatz, Varsha V. Moudgal, Susan M. Seo, and Jette E. Kristiansen

Phenothiazines and Thioxanthenes Inhibit Multidrug Efflux Pump Activity in Staphylococcus aureus
Antimicrob. Agents Chemother. 2003 47: 719-726. [Abstract] [Full Text] [PDF]  

Sally A. Turner, Shelley N. Luck, Harry Sakellaris, Kumar Rajakumar, and Ben Adler

Molecular Epidemiology of the SRL Pathogenicity Island
Antimicrob. Agents Chemother. 2003 47: 727-734. [Abstract] [Full Text] [PDF]  

Laurent Poirel, Claire Héritier, Isabelle Podglajen, Wladimir Sougakoff, Laurent Gutmann, and Patrice Nordmann

Emergence in Klebsiella pneumoniae of a Chromosome-Encoded SHV ß-Lactamase That Compromises the Efficacy of Imipenem
Antimicrob. Agents Chemother. 2003 47: 755-758. [Abstract] [Full Text] [PDF]  

Kristin H. Dahl, Torunn P. Røkenes, Eirik W. Lundblad, and Arnfinn Sundsfjord

Nonconjugative Transposition of the vanB-Containing Tn5382-Like Element in Enterococcus faecium
Antimicrob. Agents Chemother. 2003 47: 786-789. [Abstract] [Full Text] [PDF]  

Hui Wang, Swathi Kelkar, Weiyuan Wu, Minjun Chen, and John P. Quinn

Clinical Isolates of Enterobacteriaceae Producing Extended-Spectrum ß-Lactamases: Prevalence of CTX-M-3 at a Hospital in China
Antimicrob. Agents Chemother. 2003 47: 790-793. [Abstract] [Full Text] [PDF]  

Claire Poyart, Laurence Jardy, Gilles Quesne, Patrick Berche, and Patrick Trieu-Cuot

Genetic Basis of Antibiotic Resistance in Streptococcus agalactiae Strains Isolated in a French Hospital
Antimicrob. Agents Chemother. 2003 47: 794-797. [Abstract] [Full Text] [PDF]  

Anders Hay Sørensen, Lars Hestbjerg Hansen, Elsebetta Johannesen, and Søren J. Sørensen

Conjugative Plasmid Conferring Resistance to Olaquindox
Antimicrob. Agents Chemother. 2003 47: 798-799. [Abstract] [Full Text] [PDF]  

Mechanisms of Action:

T. Theis, M. Wedde, V. Meyer, and U. Stahl

The Antifungal Protein from Aspergillus giganteus Causes Membrane Permeabilization
Antimicrob. Agents Chemother. 2003 47: 588-593. [Abstract] [Full Text] [PDF]  

Libuse A. Bobek and Hongsa Situ

MUC7 20-Mer: Investigation of Antimicrobial Activity, Secondary Structure, and Possible Mechanism of Antifungal Action
Antimicrob. Agents Chemother. 2003 47: 643-652. [Abstract] [Full Text] [PDF]  

Yanmin Hu, Anthony R. M. Coates, and Denis A. Mitchison

Sterilizing Activities of Fluoroquinolones against Rifampin-Tolerant Populations of Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 2003 47: 653-657. [Abstract] [Full Text] [PDF]  

Francois Malouin, Johanne Blais, Suzanne Chamberland, Monica Hoang, Craig Park, Christin Chan, Kristina Mathias, Samia Hakem, Kelly Dupree, Eric Liu, Tien Nguyen, and Michael N. Dudley

RWJ-54428 (MC-02,479), a New Cephalosporin with High Affinity for Penicillin-Binding Proteins, Including PBP 2a, and Stability to Staphylococcal Beta-Lactamases
Antimicrob. Agents Chemother. 2003 47: 658-664. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

Bertrand Lell, Ronnatrai Ruangweerayut, Jochen Wiesner, Michel Anoumou Missinou, Andreas Schindler, Thomas Baranek, Martin Hintz, David Hutchinson, Hassan Jomaa, and Peter Gottfried Kremsner

Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria
Antimicrob. Agents Chemother. 2003 47: 735-738. [Abstract] [Full Text] [PDF]  

Letters:

Frank Møller Aarestrup, Camilla Wiuff, Kåre Mølbak, and E. John Threlfall

Is It Time To Change Fluoroquinolone Breakpoints for Salmonella spp.?
Antimicrob. Agents Chemother. 2003 47: 827-829. [Full Text] [PDF]  

Mark E. Jones, James A. Karlowsky, Renée Blosser-Middleton, Ian Critchley, Elena Karginova, Clyde Thornsberry, and Daniel F. Sahm

Reinterpretation of Susceptibility Data Using Current NCCLS Breakpoint Criteria
Antimicrob. Agents Chemother. 2003 47: 830. [Full Text] [PDF]  

Author's Correction:

D. R. Snydman, N. V. Jacobus, L. A. McDermott, R. Ruthazer, E. Goldstein, S. Finegold, L. Harrell, D. W. Hecht, S. Jenkins, C. Pierson, R. Venezia, J. Rihs, and S. L. Gorbach

In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms
Antimicrob. Agents Chemother. 2003 47: 831. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.