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Guest Commentary:

Jacques Grosset

Mycobacterium tuberculosis in the Extracellular Compartment: an Underestimated Adversary
Antimicrob. Agents Chemother. 2003 47: 833-836. [Full Text] [PDF]  

Minireviews:

S. Rohrer and B. Berger-Bächi

FemABX Peptidyl Transferases: a Link between Branched-Chain Cell Wall Peptide Formation and ß-Lactam Resistance in Gram-Positive Cocci
Antimicrob. Agents Chemother. 2003 47: 837-846. [Full Text] [PDF]  

Mechanisms of Action:

Sophie Brun, Christophe Aubry, Osana Lima, Robert Filmon, Thierry Bergès, Dominique Chabasse, and Jean-Philippe Bouchara

Relationships between Respiration and Susceptibility to Azole Antifungals in Candida glabrata
Antimicrob. Agents Chemother. 2003 47: 847-853. [Abstract] [Full Text] [PDF]  

Christian G. Noble, Faye M. Barnard, and Anthony Maxwell

Quinolone-DNA Interaction: Sequence-Dependent Binding to Single-Stranded DNA Reflects the Interaction within the Gyrase-DNA Complex
Antimicrob. Agents Chemother. 2003 47: 854-862. [Abstract] [Full Text] [PDF]  

Christine D. Hardy and Nicholas R. Cozzarelli

Alteration of Escherichia coli Topoisomerase IV to Novobiocin Resistance
Antimicrob. Agents Chemother. 2003 47: 941-947. [Abstract] [Full Text] [PDF]  

Julia Elisabeth Bandow, Heike Brötz, Lars Ingo Ole Leichert, Harald Labischinski, and Michael Hecker

Proteomic Approach to Understanding Antibiotic Action
Antimicrob. Agents Chemother. 2003 47: 948-955. [Abstract] [Full Text] [PDF]  

Chiatogu Onyewu, Jill R. Blankenship, Maurizio Del Poeta, and Joseph Heitman

Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans, Candida glabrata, and Candida krusei
Antimicrob. Agents Chemother. 2003 47: 956-964. [Abstract] [Full Text] [PDF]  

Hongxia Zhao and Paavo K. J. Kinnunen

Modulation of the Activity of Secretory Phospholipase A₂ by Antimicrobial Peptides
Antimicrob. Agents Chemother. 2003 47: 965-971. [Abstract] [Full Text] [PDF]  

Mechanisms of Resistance:

Patricia Stutzmann Meier, Silvia Utz, Suzanne Aebi, and Kathrin Mühlemann

Low-Level Resistance to Rifampin in Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2003 47: 863-868. [Abstract] [Full Text] [PDF]  

Elisabeth Schmutz, Agnes Mühlenweg, Shu-Ming Li, and Lutz Heide

Resistance Genes of Aminocoumarin Producers: Two Type II Topoisomerase Genes Confer Resistance against Coumermycin A₁ and Clorobiocin
Antimicrob. Agents Chemother. 2003 47: 869-877. [Abstract] [Full Text] [PDF]  

A. Villedieu, M. L. Diaz-Torres, N. Hunt, R. McNab, D. A. Spratt, M. Wilson, and P. Mullany

Prevalence of Tetracycline Resistance Genes in Oral Bacteria
Antimicrob. Agents Chemother. 2003 47: 878-882. [Abstract] [Full Text] [PDF]  

Claudio D. Miranda, Corinna Kehrenberg, Catherine Ulep, Stefan Schwarz, and Marilyn C. Roberts

Diversity of Tetracycline Resistance Genes in Bacteria from Chilean Salmon Farms
Antimicrob. Agents Chemother. 2003 47: 883-888. [Abstract] [Full Text] [PDF]  

Charles R. Dean, Melissa A. Visalli, Steven J. Projan, Phaik-Eng Sum, and Patricia A. Bradford

Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
Antimicrob. Agents Chemother. 2003 47: 972-978. [Abstract] [Full Text] [PDF]  

Naoki Kato, Kikuo Yamazoe, Chang-Gyun Han, and Eiichi Ohtsubo

New Insertion Sequence Elements in the Upstream Region of cfiA in Imipenem-Resistant Bacteroides fragilis Strains
Antimicrob. Agents Chemother. 2003 47: 979-985. [Abstract] [Full Text] [PDF]  

Mihaela Peric, Bülent Bozdogan, Michael R. Jacobs, and Peter C. Appelbaum

Effects of an Efflux Mechanism and Ribosomal Mutations on Macrolide Susceptibility of Haemophilus influenzae Clinical Isolates
Antimicrob. Agents Chemother. 2003 47: 1017-1022. [Abstract] [Full Text] [PDF]  

Xilin Zhao, William Eisner, Nathan Perl-Rosenthal, Barry Kreiswirth, and Karl Drlica

Mutant Prevention Concentration of Garenoxacin (BMS-284756) for Ciprofloxacin-Susceptible or -Resistant Staphylococcus aureus
Antimicrob. Agents Chemother. 2003 47: 1023-1027. [Abstract] [Full Text] [PDF]  

Susan Boyle-Vavra, Shaohui Yin, Mamatha Challapalli, and Robert S. Daum

Transcriptional Induction of the Penicillin-Binding Protein 2 Gene in Staphylococcus aureus by Cell Wall-Active Antibiotics Oxacillin and Vancomycin
Antimicrob. Agents Chemother. 2003 47: 1028-1036. [Abstract] [Full Text] [PDF]  

Christian H. Gross, Jonathan D. Parsons, Trudy H. Grossman, Paul S. Charifson, Steven Bellon, James Jernee, Maureen Dwyer, Stephen P. Chambers, William Markland, Martyn Botfield, and Scott A. Raybuck

Active-Site Residues of Escherichia coli DNA Gyrase Required in Coupling ATP Hydrolysis to DNA Supercoiling and Amino Acid Substitutions Leading to Novobiocin Resistance
Antimicrob. Agents Chemother. 2003 47: 1037-1046. [Abstract] [Full Text] [PDF]  

Fahd K. Majiduddin and Timothy Palzkill

Amino Acid Sequence Requirements at Residues 69 and 238 for the SME-1 ß-Lactamase To Confer Resistance to ß-Lactam Antibiotics
Antimicrob. Agents Chemother. 2003 47: 1062-1067. [Abstract] [Full Text] [PDF]  

James T. H. Jo, Fiona S. L. Brinkman, and Robert E. W. Hancock

Aminoglycoside Efflux in Pseudomonas aeruginosa: Involvement of Novel Outer Membrane Proteins
Antimicrob. Agents Chemother. 2003 47: 1101-1111. [Abstract] [Full Text] [PDF]  

C. Betriu, E. Culebras, M. Gómez, I. Rodríguez-Avial, B. A. Sánchez, M. C. Ágreda, and J. J. Picazo

Erythromycin and Clindamycin Resistance and Telithromycin Susceptibility in Streptococcus agalactiae
Antimicrob. Agents Chemother. 2003 47: 1112-1114. [Abstract] [Full Text] [PDF]  

Ashraf M. M. Essa, Daniel J. Julian, Stephen P. Kidd, Nigel L. Brown, and Jon L. Hobman

Mercury Resistance Determinants Related to Tn21, Tn1696, and Tn5053 in Enterobacteria from the Preantibiotic Era
Antimicrob. Agents Chemother. 2003 47: 1115-1119. [Abstract] [Full Text] [PDF]  

T. M. Diaz-Guerra, E. Mellado, M. Cuenca-Estrella, and J. L. Rodriguez-Tudela

A Point Mutation in the 14-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus
Antimicrob. Agents Chemother. 2003 47: 1120-1124. [Abstract] [Full Text] [PDF]  

Sylvie Vacher, Armelle Ménard, Elisabeth Bernard, and Francis Mégraud

PCR-Restriction Fragment Length Polymorphism Analysis for Detection of Point Mutations Associated with Macrolide Resistance in Campylobacter spp.
Antimicrob. Agents Chemother. 2003 47: 1125-1128. [Abstract] [Full Text] [PDF]  

Maria del Mar Lleò, Barbara Bonato, Caterina Signoretto, and Pietro Canepari

Vancomycin Resistance Is Maintained in Enterococci in the Viable but Nonculturable State and after Division Is Resumed
Antimicrob. Agents Chemother. 2003 47: 1154-1156. [Abstract] [Full Text] [PDF]  

L. Armand-Lefèvre, V. Leflon-Guibout, J. Bredin, F. Barguellil, A. Amor, J. M. Pagès, and M.-H. Nicolas-Chanoine

Imipenem Resistance in Salmonella enterica Serovar Wien Related to Porin Loss and CMY-4 ß-Lactamase Production
Antimicrob. Agents Chemother. 2003 47: 1165-1168. [Abstract] [Full Text] [PDF]  

Vincent Perreten and Patrick Boerlin

A New Sulfonamide Resistance Gene (sul3) in Escherichia coli Is Widespread in the Pig Population of Switzerland
Antimicrob. Agents Chemother. 2003 47: 1169-1172. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Cristina Parolin, Barbara Gatto, Claudia Del Vecchio, Teresa Pecere, Enzo Tramontano, Violetta Cecchetti, Arnaldo Fravolini, Sara Masiero, Manlio Palumbo, and Giorgio Palù

New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action
Antimicrob. Agents Chemother. 2003 47: 889-896. [Abstract] [Full Text] [PDF]  

Jean-Baptiste Guiard-Schmid, Jean-Marie Poirier, Jean-Luc Meynard, Philippe Bonnard, Ayi Hola Gbadoe, Corinne Amiel, Frédérique Calligaris, Bruno Abraham, Gilles Pialoux, Pierre-Marie Girard, Patrice Jaillon, and Willy Rozenbaum

High Variability of Plasma Drug Concentrations in Dual Protease Inhibitor Regimens
Antimicrob. Agents Chemother. 2003 47: 986-990. [Abstract] [Full Text] [PDF]  

Stacy D. Brown, Michael G. Bartlett, and Catherine A. White

Pharmacokinetics of Intravenous Acyclovir, Zidovudine, and Acyclovir-Zidovudine in Pregnant Rats
Antimicrob. Agents Chemother. 2003 47: 991-996. [Abstract] [Full Text] [PDF]  

Fatih M. Uckun, Francis Rajamohan, Sharon Pendergrass, Zahide Ozer, Barbara Waurzyniak, and Chen Mao

Structure-Based Design and Engineering of a Nontoxic Recombinant Pokeweed Antiviral Protein with Potent Anti-Human Immunodeficiency Virus Activity
Antimicrob. Agents Chemother. 2003 47: 1052-1061. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

Demetra Kavatha, Helen Giamarellou, Zoe Alexiou, Nickolas Vlachogiannis, Stavroula Pentea, Thomas Gozadinos, Garyphalia Poulakou, Agissilaos Hatzipapas, and George Koratzanis

Cefpodoxime-Proxetil versus Trimethoprim-Sulfamethoxazole for Short-Term Therapy of Uncomplicated Acute Cystitis in Women
Antimicrob. Agents Chemother. 2003 47: 897-900. [Abstract] [Full Text] [PDF]  

Steffen Borrmann, Ayola A. Adegnika, Michel A. Missinou, Ronald K. Binder, Saadou Issifou, Andreas Schindler, Pierre-Blaise Matsiegui, Jürgen F. J. Kun, Sanjeev Krishna, Bertrand Lell, and Peter G. Kremsner

Short-Course Artesunate Treatment of Uncomplicated Plasmodium falciparum Malaria in Gabon
Antimicrob. Agents Chemother. 2003 47: 901-904. [Abstract] [Full Text] [PDF]  

Walter Fonseca, Kalle Hoppu, Luís C. Rey, João Amaral, and Shamim Qazi

Comparing Pharmacokinetics of Amoxicillin Given Twice or Three Times per Day to Children Older than 3 Months with Pneumonia
Antimicrob. Agents Chemother. 2003 47: 997-1001. [Abstract] [Full Text] [PDF]  

Spotswood L. Spruance, Terry M. Jones, Mark M. Blatter, Mauricio Vargas-Cortes, Judy Barber, Joanne Hill, Donna Goldstein, and Margaret Schultz

High-Dose, Short-Duration, Early Valacyclovir Therapy for Episodic Treatment of Cold Sores: Results of Two Randomized, Placebo-Controlled, Multicenter Studies
Antimicrob. Agents Chemother. 2003 47: 1072-1080. [Abstract] [Full Text] [PDF]  

Pharmacology:

Brent W. Gunderson, Khalid H. Ibrahim, Laurie B. Hovde, Timothy L. Fromm, Michael D. Reed, and John C. Rotschafer

Synergistic Activity of Colistin and Ceftazidime against Multiantibiotic-Resistant Pseudomonas aeruginosa in an In Vitro Pharmacodynamic Model
Antimicrob. Agents Chemother. 2003 47: 905-909. [Abstract] [Full Text] [PDF]  

Florent Rougier, Daniel Claude, Michel Maurin, Alexandre Sedoglavic, Michel Ducher, Stéphane Corvaisier, Roger Jelliffe, and Pascal Maire

Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control
Antimicrob. Agents Chemother. 2003 47: 1010-1016. [Abstract] [Full Text] [PDF]  

Cristina Seral, Jean-Michel Michot, Hugues Chanteux, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, and Françoise Van Bambeke

Influence of P-Glycoprotein Inhibitors on Accumulation of Macrolides in J774 Murine Macrophages
Antimicrob. Agents Chemother. 2003 47: 1047-1051. [Abstract] [Full Text] [PDF]  

M. W. Pletz, V. Preechachatchaval, J. Bulitta, M. Allewelt, O. Burkhardt, and H. Lode

ABT-773: Pharmacokinetics and Interactions with Ranitidine and Sucralfate
Antimicrob. Agents Chemother. 2003 47: 1129-1131. [Abstract] [Full Text] [PDF]  

Yong-Taek Jun, Hee-Jung Kim, Min-Jin Song, Ji-Hyang Lim, Dong-Gun Lee, Kyung-Ja Han, Su-Mi Choi, Jin-Hong Yoo, Wan-Shik Shin, and Jung-Hyun Choi

In Vitro Effects of Ciprofloxacin and Roxithromycin on Apoptosis of Jurkat T Lymphocytes
Antimicrob. Agents Chemother. 2003 47: 1161-1164. [Abstract] [Full Text] [PDF]  

Susceptibility:

David W. Hecht and J. R. Osmolski

Activities of Garenoxacin (BMS-284756) and Other Agents against Anaerobic Clinical Isolates
Antimicrob. Agents Chemother. 2003 47: 910-916. [Abstract] [Full Text] [PDF]  

Diane Ordway, Miguel Viveiros, Clara Leandro, Rosário Bettencourt, Josefina Almeida, Marta Martins, Jette E. Kristiansen, Joseph Molnar, and Leonard Amaral

Clinical Concentrations of Thioridazine Kill Intracellular Multidrug-Resistant Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 2003 47: 917-922. [Abstract] [Full Text] [PDF]  

Takaji Fujimura, Yoshinori Yamano, Isamu Yoshida, Jingoro Shimada, and Shogo Kuwahara

In Vitro Activity of S-3578, a New Broad-Spectrum Cephalosporin Active against Methicillin-Resistant Staphylococci
Antimicrob. Agents Chemother. 2003 47: 923-931. [Abstract] [Full Text] [PDF]  

M. A. Pfaller, D. J. Diekema, S. A. Messer, R. J. Hollis, and R. N. Jones

In Vitro Activities of Caspofungin Compared with Those of Fluconazole and Itraconazole against 3,959 Clinical Isolates of Candida spp., Including 157 Fluconazole-Resistant Isolates
Antimicrob. Agents Chemother. 2003 47: 1068-1071. [Abstract] [Full Text] [PDF]  

Raymond P. Smith, Aldona L. Baltch, Phyllis B. Michelsen, William J. Ritz, and Richard Alteri

Use of the Microbial Growth Curve in Postantibiotic Effect Studies of Legionella pneumophila
Antimicrob. Agents Chemother. 2003 47: 1081-1087. [Abstract] [Full Text] [PDF]  

Melinda M. Neuhauser, Jennifer L. Prause, Larry H. Danziger, and Susan L. Pendland

In Vitro Bactericidal Activities of ABT-773 against ermB Strains of Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2003 47: 1132-1134. [Abstract] [Full Text] [PDF]  

Patricia M. Roblin, Tamara Reznik, Andrei Kutlin, and Margaret R. Hammerschlag

In Vitro Activities of Rifamycin Derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657, and ABI-1131 against Chlamydia trachomatis and Recent Clinical Isolates of Chlamydia pneumoniae
Antimicrob. Agents Chemother. 2003 47: 1135-1136. [Abstract] [Full Text] [PDF]  

Valerie A. Ferro, Fiona Bradbury, Pamela Cameron, Eisin Shakir, Sabita R. Rahman, and William H. Stimson

In Vitro Susceptibilities of Shigella flexneri and Streptococcus pyogenes to Inner Gel of Aloe barbadensis Miller
Antimicrob. Agents Chemother. 2003 47: 1137-1139. [Abstract] [Full Text] [PDF]  

G. A. Pankuch, M. R. Jacobs, and P. C. Appelbaum

Postantibiotic Effects of Garenoxacin (BMS-284756) against 12 Gram-Positive or -Negative Organisms
Antimicrob. Agents Chemother. 2003 47: 1140-1142. [Abstract] [Full Text] [PDF]  

Lois M. Ednie, Ashok Rattan, Michael R. Jacobs, and P. C. Appelbaum

Antianaerobe Activity of RBX 7644 (Ranbezolid), a New Oxazolidinone, Compared with Those of Eight Other Agents
Antimicrob. Agents Chemother. 2003 47: 1143-1147. [Abstract] [Full Text] [PDF]  

Dianne B. Hoellman, Gengrong Lin, Lois M. Ednie, Ashok Rattan, Michael R. Jacobs, and Peter C. Appelbaum

Antipneumococcal and Antistaphylococcal Activities of Ranbezolid (RBX 7644), a New Oxazolidinone, Compared to Those of Other Agents
Antimicrob. Agents Chemother. 2003 47: 1148-1150. [Abstract] [Full Text] [PDF]  

Eugene Lin, Ronald J. Stanek, and Maurice A. Mufson

Lack of Synergy of Erythromycin Combined with Penicillin or Cefotaxime against Streptococcus pneumoniae In Vitro
Antimicrob. Agents Chemother. 2003 47: 1151-1153. [Abstract] [Full Text] [PDF]  

Louise A. Rollins-Smith, Cynthia Carey, J. Michael Conlon, Laura K. Reinert, Jennifer K. Doersam, Tomas Bergman, Jerzy Silberring, Hilkka Lankinen, and David Wade

Activities of Temporin Family Peptides against the Chytrid Fungus (Batrachochytrium dendrobatidis) Associated with Global Amphibian Declines
Antimicrob. Agents Chemother. 2003 47: 1157-1160. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

N. Kömerik, H. Nakanishi, A. J. MacRobert, B. Henderson, P. Speight, and M. Wilson

In Vivo Killing of Porphyromonas gingivalis by Toluidine Blue-Mediated Photosensitization in an Animal Model
Antimicrob. Agents Chemother. 2003 47: 932-940. [Abstract] [Full Text] [PDF]  

M. B. Kerrn, N. Frimodt-Møller, and F. Espersen

Effects of Sulfamethizole and Amdinocillin against Escherichia coli Strains (with Various Susceptibilities) in an Ascending Urinary Tract Infection Mouse Model
Antimicrob. Agents Chemother. 2003 47: 1002-1009. [Abstract] [Full Text] [PDF]  

Alasdair P. MacGowan, Chris A. Rogers, H. Alan Holt, and Karen E. Bowker

Activities of Moxifloxacin against, and Emergence of Resistance in, Streptococcus pneumoniae and Pseudomonas aeruginosa in an In Vitro Pharmacokinetic Model
Antimicrob. Agents Chemother. 2003 47: 1088-1095. [Abstract] [Full Text] [PDF]  

Alasdair P. MacGowan and Karen E. Bowker

Mechanism of Fluoroquinolone Resistance Is an Important Factor in Determining the Antimicrobial Effect of Gemifloxacin against Streptococcus pneumoniae in an In Vitro Pharmacokinetic Model
Antimicrob. Agents Chemother. 2003 47: 1096-1100. [Abstract] [Full Text] [PDF]  

Letters:

Eric Adehossi, Philippe Parola, Cedric Foucault, Jean Delmont, Philippe Brouqui, Sekene Badiaga, and Stephane Ranque

Three-Day Quinine-Clindamycin Treatment of Uncomplicated Falciparum Malaria Imported from the Tropics
Antimicrob. Agents Chemother. 2003 47: 1173. [Full Text] [PDF]  

Deborah M. Thielking, Michelle S. Destefano, Michael H. Cynamon, and Anthony E. T. Yeo

Enhanced In Vitro Activity of Dihydrofolate Reductase and Dihydropteroase Synthase Inhibitors in Combination against Nocardia spp.
Antimicrob. Agents Chemother. 2003 47: 1174. [Full Text] [PDF]  

Richard K. Haynes, Diego Monti, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, and Piero Olliaro

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
Antimicrob. Agents Chemother. 2003 47: 1175. [Full Text] [PDF]  

Emanuele Nicastri, Loredana Sarmati, Massimo Andreoni, Véronique Joly, Diane Descamps, Philippe Flandre, and Patrick Yeni

Stavudine Protective Function and Emergence of Lamivudine Resistance
Antimicrob. Agents Chemother. 2003 47: 1176. [Full Text] [PDF]  

Author's Correction:

Valery Fikkert, Peter Cherepanov, Kristel Van Laethem, Anke Hantson, Barbara Van Remoortel, Christophe Pannecouque, Erik De Clercq, Zeger Debyser, Anne-Mieke Vandamme, and Myriam Witvrouw

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors
Antimicrob. Agents Chemother. 2003 47: 1177. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.