AAC -- Table of Contents (April 1 2003, 47 [4])

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Contents: April 2003, Volume 47, Issue 4

       Minireviews

       Experimental Therapeutics

       Mechanisms of Action

       Mechanisms of Resistance

       Antiviral Agents

       Chemistry; Biosynthesis

       Pharmacology

       Susceptibility

       Letters

       Errata

Other Issues

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Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Minireviews:

In Vivo Pharmacodynamics of Antifungal Drugs in Treatment of Candidiasis
David Andes
Antimicrob. Agents Chemother. April 2003 47: 1179-1186;
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Experimental Therapeutics:

In Vivo Pharmacodynamics of HMR 3270, a Glucan Synthase Inhibitor, in a Murine Candidiasis Model
D. Andes, K. Marchillo, J. Lowther, A. Bryskier, T. Stamstad, and R. Conklin
Antimicrob. Agents Chemother. April 2003 47: 1187-1192;
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In Vivo Pharmacodynamics of a New Triazole, Ravuconazole, in a Murine Candidiasis Model
D. Andes, K. Marchillo, T. Stamstad, and R. Conklin
Antimicrob. Agents Chemother. April 2003 47: 1193-1199;
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Isolation of Three Mycobacterium ulcerans Strains Resistant to Rifampin after Experimental Chemotherapy of Mice
Laurent Marsollier, Nadine Honoré, Pierre Legras, Anne Lise Manceau, Henri Kouakou, Bernard Carbonnelle, and Stewart T. Cole
Antimicrob. Agents Chemother. April 2003 47: 1228-1232;
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Vancomycin Treatment Failure Associated with Heterogeneous Vancomycin-Intermediate Staphylococcus aureus in a Patient with Endocarditis and in the Rabbit Model of Endocarditis
Matthew R. Moore, Françoise Perdreau-Remington, and Henry F. Chambers
Antimicrob. Agents Chemother. April 2003 47: 1262-1266;
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Use of Genetically Engineered Phage To Deliver Antimicrobial Agents to Bacteria: an Alternative Therapy for Treatment of Bacterial Infections
Caroline Westwater, Laura M. Kasman, David A. Schofield, Phillip A. Werner, Joseph W. Dolan, Michael G. Schmidt, and James S. Norris
Antimicrob. Agents Chemother. April 2003 47: 1301-1307;
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Bactericidal Activities of Methoxyfluoroquinolones Gatifloxacin and Moxifloxacin against Aerobic and Anaerobic Respiratory Pathogens in Serum
Gary E. Stein, Sharon Schooley, Kerin L. Tyrrell, Diane M. Citron, and Ellie J. C. Goldstein
Antimicrob. Agents Chemother. April 2003 47: 1308-1312;
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Rifampin Followed by Ceftriaxone for Experimental Meningitis Decreases Lipoteichoic Acid Concentrations in Cerebrospinal Fluid and Reduces Neuronal Damage in Comparison to Ceftriaxone Alone
Joachim Gerber, Karin Pohl, Valeska Sander, Stephanie Bunkowski, and Roland Nau
Antimicrob. Agents Chemother. April 2003 47: 1313-1317;
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Pharmacokinetics and Efficacy of Linezolid in a Gerbil Model of Streptococcus pneumoniae-Induced Acute Otitis Media
William R. Humphrey, Mark H. Shattuck, Raymond J. Zielinski, Ming-Shang T. Kuo, John J. Biermacher, Donald P. Smith, Jana L. Jensen, Ronda D. Schaadt, Gary E. Zurenko, and Ivan M. Richards
Antimicrob. Agents Chemother. April 2003 47: 1355-1363;
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Activity of Posaconazole against Pseudallescheria boydii: In Vitro and In Vivo Assays
Gloria M. González, Rolando Tijerina, Laura K. Najvar, Rosie Bocanegra, Michael G. Rinaldi, David Loebenberg, and John R. Graybill
Antimicrob. Agents Chemother. April 2003 47: 1436-1438;
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Efficacy of Micafungin Alone or in Combination against Systemic Murine Aspergillosis
Javier Capilla Luque, Karl V. Clemons, and David A. Stevens
Antimicrob. Agents Chemother. April 2003 47: 1452-1455;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Sublethal Injury and Resuscitation of Candida albicans after Amphotericin B Treatment
Robert S. Liao, Robert P. Rennie, and James A. Talbot
Antimicrob. Agents Chemother. April 2003 47: 1200-1206;
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Mechanisms of Resistance:

Drug Resistance Is Not Directly Affected by Mating Type Locus Zygosity in Candida albicans
Claude Pujol, Shawn A. Messer, Michael Pfaller, and David R. Soll
Antimicrob. Agents Chemother. April 2003 47: 1207-1212;
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Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei
Takashi Fukuoka, Douglas A. Johnston, Carol A. Winslow, Marcel J. de Groot, Catherine Burt, Christopher A. Hitchcock, and Scott G. Filler
Antimicrob. Agents Chemother. April 2003 47: 1213-1219;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genome-Wide Expression Profile Analysis Reveals Coordinately Regulated Genes Associated with Stepwise Acquisition of Azole Resistance in Candida albicans Clinical Isolates
P. David Rogers and Katherine S. Barker
Antimicrob. Agents Chemother. April 2003 47: 1220-1227;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single Nucleotide Polymorphisms in Genes Associated with Isoniazid Resistance in Mycobacterium tuberculosis
Srinivas V. Ramaswamy, Robert Reich, Shu-Jun Dou, Linda Jasperse, Xi Pan, Audrey Wanger, Teresa Quitugua, and Edward A. Graviss
Antimicrob. Agents Chemother. April 2003 47: 1241-1250;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Nutrient Limitation and Stationary-Phase Existence in Klebsiella pneumoniae Biofilm Resistance to Ampicillin and Ciprofloxacin
Jeff N. Anderl, Jeff Zahller, Frank Roe, and Philip S. Stewart
Antimicrob. Agents Chemother. April 2003 47: 1251-1256;
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High-Efficiency Generation of Antibiotic-Resistant Strains of Streptococcus pneumoniae by PCR and Transformation
Antonio J. Martín-Galiano and Adela G. de la Campa
Antimicrob. Agents Chemother. April 2003 47: 1257-1261;
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Isolation of Antibiotic Hypersusceptibility Mutants of Acinetobacter spp. by Selection for DNA Release
Hyunwoo Lee, Nora Vázquez-Laslop, Katya A. Klyachko, and Alex A. Neyfakh
Antimicrob. Agents Chemother. April 2003 47: 1267-1274;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Flucytosine-Fluconazole Cross-Resistance in Purine-Cytosine Permease-Deficient Candida lusitaniae Clinical Isolates: Indirect Evidence of a Fluconazole Uptake Transporter
Thierry Noël, Fabienne François, Patrick Paumard, Christiane Chastin, Daniel Brèthes, and Jean Villard
Antimicrob. Agents Chemother. April 2003 47: 1275-1284;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron-Containing IncU R Plasmids pRAS1 and pAr-32 from the Fish Pathogen Aeromonas salmonicida
Henning Sørum, Trine M. L'Abée-Lund, Asta Solberg, and Anette Wold
Antimicrob. Agents Chemother. April 2003 47: 1285-1290;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Imipenem Resistance in a Salmonella Clinical Strain Due to Plasmid-Mediated Class A Carbapenemase KPC-2
Vivi Miriagou, Leonidas S. Tzouvelekis, Shannon Rossiter, Eva Tzelepi, Frederick J. Angulo, and Jean M. Whichard
Antimicrob. Agents Chemother. April 2003 47: 1297-1300;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chromosomal aadD2 Encodes an Aminoglycoside Nucleotidyltransferase in Bacillus clausii
Bülent Bozdogan, Sébastien Galopin, Guy Gerbaud, Patrice Courvalin, and Roland Leclercq
Antimicrob. Agents Chemother. April 2003 47: 1343-1346;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Determination of Point Mutation Haplotypes in the Dihydrofolate Reductase and Dihydropteroate Synthase of Plasmodium falciparum in Three Districts of Northern Tanzania
Richard J. Pearce, Chris Drakeley, Daniel Chandramohan, Frank Mosha, and Cally Roper
Antimicrob. Agents Chemother. April 2003 47: 1347-1354;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides
Didier Hocquet, Christelle Vogne, Farid El Garch, Anne Vejux, Naomasa Gotoh, Angela Lee, Olga Lomovskaya, and Patrick Plésiat
Antimicrob. Agents Chemother. April 2003 47: 1371-1375;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Epidemiology of Rifampin ADP-Ribosyltransferase (arr-2) and Metallo-ß-Lactamase (bla_IMP-4) Gene Cassettes in Class 1 Integrons in Acinetobacter Strains Isolated from Blood Cultures in 1997 to 2000
Elizabeth T. S. Houang, Yiu-Wai Chu, Wai-Sing Lo, Ka-Yi Chu, and Augustine F. B. Cheng
Antimicrob. Agents Chemother. April 2003 47: 1382-1390;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of and Resistance to Moxifloxacin in Staphylococcus aureus
Dilek Ince, Xiamei Zhang, and David C. Hooper
Antimicrob. Agents Chemother. April 2003 47: 1410-1415;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Characterization of Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Isolated during Ciprofloxacin Therapy from a Patient with Bronchiectasis
Adela G. de la Campa, María-José Ferrandiz, Fe Tubau, Román Pallarés, Federico Manresa, and Josefina Liñares
Antimicrob. Agents Chemother. April 2003 47: 1419-1422;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiplex PCR for Detection of Aminoglycoside Resistance Genes in Enterococci
Sergei B. Vakulenko, Susan M. Donabedian, Anatoliy M. Voskresenskiy, Marcus J. Zervos, Stephen A. Lerner, and Joseph W. Chow
Antimicrob. Agents Chemother. April 2003 47: 1423-1426;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron-Associated Antibiotic Resistance in Salmonella enterica Serovar Typhi from Asia
Marie-Cécile Ploy, Delphine Chainier, Nhu Hoa Tran Thi, Isabelle Poilane, Philippe Cruaud, François Denis, Anne Collignon, and Thierry Lambert
Antimicrob. Agents Chemother. April 2003 47: 1427-1429;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Tetracycline Resistance Determinant from the Oral Metagenome
M. L. Diaz-Torres, R. McNab, D. A. Spratt, A. Villedieu, N. Hunt, M. Wilson, and P. Mullany
Antimicrob. Agents Chemother. April 2003 47: 1430-1432;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization and Antimicrobial Susceptibility of Fluoroquinolone-Resistant or -Susceptible Streptococcus pneumoniae from Hong Kong
Ian Morrissey, David J. Farrell, Sarah Bakker, Sylvie Buckridge, and David Felmingham
Antimicrob. Agents Chemother. April 2003 47: 1433-1435;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

PCR-Oligonucleotide Ligation Assay for Detection of Point Mutations Associated with Quinolone Resistance in Streptococcus pneumoniae
Mai-Ha Bui, Gregory G. Stone, Angela M. Nilius, Laurel Almer, and Robert K. Flamm
Antimicrob. Agents Chemother. April 2003 47: 1456-1459;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

mecA-blaZ Corepressors in Clinical Staphylococcus aureus Isolates
Adriana E. Rosato, Barry N. Kreiswirth, William A. Craig, William Eisner, Michael W. Climo, and Gordon L. Archer
Antimicrob. Agents Chemother. April 2003 47: 1460-1463;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Frequency of Mutation to Rifampin Resistance in Streptococcus pneumoniae Clinical Strains: hexA and hexB Polymorphisms Do Not Account for Hypermutation
María-Isabel Morosini, María-Rosario Baquero, J. M. Sánchez-Romero, María-Cristina Negri, Juan-Carlos Galán, Rosa del Campo, J. C. Pérez-Díaz, and Fernando Baquero
Antimicrob. Agents Chemother. April 2003 47: 1464-1467;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

In Vivo Antiretroviral Activity of Stampidine in Chronically Feline Immunodeficiency Virus-Infected Cats
Fatih M. Uckun, Chun-Lin Chen, Peter Samuel, Sharon Pendergrass, T. K. Venkatachalam, Barbara Waurzyniak, and Sanjive Qazi
Antimicrob. Agents Chemother. April 2003 47: 1233-1240;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Atazanavir (BMS-232632) against a Large Panel of Human Immunodeficiency Virus Type 1 Clinical Isolates Resistant to One or More Approved Protease Inhibitors
Richard J. Colonno, Alexandra Thiry, Kay Limoli, and Neil Parkin
Antimicrob. Agents Chemother. April 2003 47: 1324-1333;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phase I Safety and Pharmacokinetic Trials of 1263W94, a Novel Oral Anti-Human Cytomegalovirus Agent, in Healthy and Human Immunodeficiency Virus-Infected Subjects
Laurene H. Wang, Richard W. Peck, Yin Yin, Jane Allanson, Rebecca Wiggs, and Mary Beth Wire
Antimicrob. Agents Chemother. April 2003 47: 1334-1342;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions of 1263W94 with Other Antiviral Agents in Inhibition of Human Cytomegalovirus Replication
Dean W. Selleseth, Christine L. Talarico, Teresa Miller, Michael W. Lutz, Karen K. Biron, and Robert J. Harvey
Antimicrob. Agents Chemother. April 2003 47: 1468-1471;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemistry; Biosynthesis:

Engineering Anthracycline Biosynthesis toward Angucyclines
Mikko Metsä-Ketelä, Kaisa Palmu, Tero Kunnari, Kristiina Ylihonko, and Pekka Mäntsälä
Antimicrob. Agents Chemother. April 2003 47: 1291-1296;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Daptomycin Pharmacokinetics and Safety following Administration of Escalating Doses Once Daily to Healthy Subjects
Barry H. Dvorchik, David Brazier, Michael F. DeBruin, and Robert D. Arbeit
Antimicrob. Agents Chemother. April 2003 47: 1318-1323;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Stability of Colistin and Colistin Methanesulfonate in Aqueous Media and Plasma as Determined by High-Performance Liquid Chromatography
Jian Li, Robert W. Milne, Roger L. Nation, John D. Turnidge, and Kingsley Coulthard
Antimicrob. Agents Chemother. April 2003 47: 1364-1370;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Metabolism of [¹⁴C]Ribavirin in Rats and Cynomolgus Monkeys
Chin-Chung Lin, Li-Tain Yeh, Trong Luu, David Lourenco, and Johnson Y. N. Lau
Antimicrob. Agents Chemother. April 2003 47: 1395-1398;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tissue Penetration by Ertapenem, a Parenteral Carbapenem Administered Once Daily, in Suction-Induced Skin Blister Fluid in Healthy Young Volunteers
T. Laethem, I. De Lepeleire, J. McCrea, J. Zhang, A. Majumdar, D. Musson, D. Rogers, S. Li, M. Guillaume, A. Parneix-Spake, and P. Deutsch
Antimicrob. Agents Chemother. April 2003 47: 1439-1442;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

In Vitro Antifungal Activity of Micafungin (FK463) against Dimorphic Fungi: Comparison of Yeast-Like and Mycelial Forms
Toru Nakai, Jun Uno, Fumiaki Ikeda, Shuichi Tawara, Kazuko Nishimura, and Makoto Miyaji
Antimicrob. Agents Chemother. April 2003 47: 1376-1381;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Piperaquine and Other 4-Aminoquinolines against Clinical Isolates of Plasmodium falciparum in Cameroon
Leonardo K. Basco and Pascal Ringwald
Antimicrob. Agents Chemother. April 2003 47: 1391-1394;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Time-Kill Studies of the Antianaerobe Activity of Garenoxacin Compared with Those of Nine Other Agents
Kim L. Credito, Michael R. Jacobs, and Peter C. Appelbaum
Antimicrob. Agents Chemother. April 2003 47: 1399-1402;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of ABT-773 against Listeria monocytogenes and Coryneform Bacteria of Clinical Interest
María del Carmen Conejo, Luis Martínez-Martínez, Álvaro Pascual, Ana Isabel Suárez, and Evelio J. Perea
Antimicrob. Agents Chemother. April 2003 47: 1403-1406;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Metronidazole and Tinidazole Activities against Metronidazole- Resistant Strains of Trichomonas vaginalis
Andrea L. Crowell, Kolby A. Sanders-Lewis, and W. Evan Secor
Antimicrob. Agents Chemother. April 2003 47: 1407-1409;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Synergy of Caspofungin and Itraconazole against Aspergillus spp.: MIC versus Minimal Effective Concentration End Points
Itamar Shalit, Yona Shadkchan, Zmira Samra, and Nir Osherov
Antimicrob. Agents Chemother. April 2003 47: 1416-1418;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Resistance in Bacteria Isolated from Subgingival Plaque in a Norwegian Population with Refractory Marginal Periodontitis
Trude Handal, Dominique A. Caugant, and Ingar Olsen
Antimicrob. Agents Chemother. April 2003 47: 1443-1446;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of a New Antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae
Patricia M. Roblin and Margaret R. Hammerschlag
Antimicrob. Agents Chemother. April 2003 47: 1447-1448;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones
Fabiane Lunardi, Michel Guzela, Andrea T. Rodrigues, Rogério Corrêa, Iriane Eger-Mangrich, Mário Steindel, Edmundo C. Grisard, Jamil Assreuy, João B. Calixto, and Adair R. S. Santos
Antimicrob. Agents Chemother. April 2003 47: 1449-1451;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Significance of Genomic DNA Group Delineation in Comparative Studies of Antimicrobial Susceptibility of Acinetobacter spp.
Elizabeth T. S. Houang, Yiu Wai Chu, K. Y. Chu, K. C. Ng, C. M. Leung, and A. F. B. Cheng
Antimicrob. Agents Chemother. April 2003 47: 1472-1475;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pathogenic Nocardia, Rhodococcus, and Related Organisms Are Highly Susceptible to Imidazole Antifungals
Eric R. Dabbs, Samantha Naidoo, Catherine Lephoto, and Natalya Nikitina
Antimicrob. Agents Chemother. April 2003 47: 1476-1478;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Letters:

Can Etest Be Used To Determine Vibrio cholerae Susceptibility to Erythromycin?
Lai-King Ng, Pam Sawatzky, Marcelo Galas, Dalia dos Prazeres Rodrigues, Ingrid Heitmann, Sandra Fernandez, and Anne Bolmström
Antimicrob. Agents Chemother. April 2003 47: 1479-1480;
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Outbreak of GES-1 ß-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae in a University Hospital in Lisbon, Portugal
A. Duarte, F. Boavida, F. Grosso, M. Correia, L. M. Lito, J. Melo Cristino, and M. J. Salgado
Antimicrob. Agents Chemother. April 2003 47: 1481-1482;
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Emergence of Nalidixic Acid-Resistant Shigella sonnei in Acute-Diarrhea Patients on Andaman and Nicobar Islands, India
Asit R. Ghosh, A. P. Sugunan, Subhash C. Sehgal, and A. P. Bharadwaj
Antimicrob. Agents Chemother. April 2003 47: 1483
[Full Text] [PDF] [Reprints and Permissions]

Lack of Evidence for Involvement of Hypermutability in Emergence of Vancomycin-Intermediate Staphylococcus aureus
Alexander J. O'Neill, Ian Chopra, Gabriele Bierbaum, Andrea Reipert, and Franziska Schaaff
Antimicrob. Agents Chemother. April 2003 47: 1484-1485;
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Errata:

In Vitro Activities of Daptomycin, Vancomycin, Quinupristin- Dalfopristin, Linezolid, and Five Other Antimicrobials against 307 Gram-Positive Anaerobic and 31 Corynebacterium Clinical Isolates
Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerrin L. Tyrrell, and Helen T. Fernandez
Antimicrob. Agents Chemother. April 2003 47: 1486
[Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.