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Minireviews:

Gerhard F. Weldhagen, Laurent Poirel, and Patrice Nordmann

Ambler Class A Extended-Spectrum ß-Lactamases in Pseudomonas aeruginosa: Novel Developments and Clinical Impact
Antimicrob. Agents Chemother. 2003 47: 2385-2392. [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Michelle Ciach, Kathleen Zong, Kevin C. Kain, and Ian Crandall

Reversal of Mefloquine and Quinine Resistance in Plasmodium falciparum with NP30
Antimicrob. Agents Chemother. 2003 47: 2393-2396. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David R. Macinga, Paul J. Renick, Kelly M. Makin, David H. Ellis, Allison A. Kreiner, Min Li, Kirk J. Rupnik, Erica M. Kincaid, Cynthia D. Wallace, Benoit Ledoussal, and Timothy W. Morris

Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones
Antimicrob. Agents Chemother. 2003 47: 2526-2537. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jared A. Silverman, Nancy G. Perlmutter, and Howard M. Shapiro

Correlation of Daptomycin Bactericidal Activity and Membrane Depolarization in Staphylococcus aureus
Antimicrob. Agents Chemother. 2003 47: 2538-2544. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Huamei Fu, Claes Dahlgren, and Johan Bylund

Subinhibitory Concentrations of the Deformylase Inhibitor Actinonin Increase Bacterial Release of Neutrophil-Activating Peptides: a New Approach to Antimicrobial Chemotherapy
Antimicrob. Agents Chemother. 2003 47: 2545-2550. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Giancarlo A. Biagini, Eric Richier, Patrick G. Bray, Michèle Calas, Henri Vial, and Stephen A. Ward

Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums
Antimicrob. Agents Chemother. 2003 47: 2584-2589. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nassira Mahmoudi, Liliane Ciceron, Jean-François Franetich, Khemais Farhati, Olivier Silvie, Wijnand Eling, Robert Sauerwein, Martin Danis, Dominique Mazier, and Francis Derouin

In Vitro Activities of 25 Quinolones and Fluoroquinolones against Liver and Blood Stage Plasmodium spp.
Antimicrob. Agents Chemother. 2003 47: 2636-2639. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Valerie Laganas, Jeffrey Alder, and Jared A. Silverman

In Vitro Bactericidal Activities of Daptomycin against Staphylococcus aureus and Enterococcus faecalis Are Not Mediated by Inhibition of Lipoteichoic Acid Biosynthesis
Antimicrob. Agents Chemother. 2003 47: 2682-2684. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

F. Javier Pérez-Victoria, Santiago Castanys, and Francisco Gamarro

Leishmania donovani Resistance to Miltefosine Involves a Defective Inward Translocation of the Drug
Antimicrob. Agents Chemother. 2003 47: 2397-2403. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Dominique Sanglard, Françoise Ischer, Tania Parkinson, Derek Falconer, and Jacques Bille

Candida albicans Mutations in the Ergosterol Biosynthetic Pathway and Resistance to Several Antifungal Agents
Antimicrob. Agents Chemother. 2003 47: 2404-2412. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nazmul Huda, Eun-Woo Lee, Jing Chen, Yuji Morita, Teruo Kuroda, Tohru Mizushima, and Tomofusa Tsuchiya

Molecular Cloning and Characterization of an ABC Multidrug Efflux Pump, VcaM, in Non-O1 Vibrio cholerae
Antimicrob. Agents Chemother. 2003 47: 2413-2417. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Amy L. Pickard, Chansuda Wongsrichanalai, Anne Purfield, Deborah Kamwendo, Kathryn Emery, Christy Zalewski, Fumihiko Kawamoto, R. Scott Miller, and Steven R. Meshnick

Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1
Antimicrob. Agents Chemother. 2003 47: 2418-2423. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Emmanuelle Pinjon, Gary P. Moran, Colin J. Jackson, Steven L. Kelly, Dominique Sanglard, David C. Coleman, and Derek J. Sullivan

Molecular Mechanisms of Itraconazole Resistance in Candida dubliniensis
Antimicrob. Agents Chemother. 2003 47: 2424-2437. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Juan-Carlos Galán, María-Isabel Morosini, María-Rosario Baquero, Milagro Reig, and Fernando Baquero

Haemophilus influenzae bla_ROB-1 Mutations in Hypermutagenic ampC Escherichia coli Conferring Resistance to Cefotaxime and ß-Lactamase Inhibitors and Increased Susceptibility to Cefaclor
Antimicrob. Agents Chemother. 2003 47: 2551-2557. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jutta Rossi, Markus Bischoff, Akihito Wada, and Brigitte Berger-Bächi

MsrR, a Putative Cell Envelope-Associated Element Involved in Staphylococcus aureus sarA Attenuation
Antimicrob. Agents Chemother. 2003 47: 2558-2564. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marc Galimand, Patrice Courvalin, and Thierry Lambert

Plasmid-Mediated High-Level Resistance to Aminoglycosides in Enterobacteriaceae Due to 16S rRNA Methylation
Antimicrob. Agents Chemother. 2003 47: 2565-2571. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Dearbháile Morris, Colette O'Hare, Maura Glennon, Majella Maher, Geraldine Corbett-Feeney, and Martin Cormican

Extended-Spectrum ß-Lactamases in Ireland, Including a Novel Enzyme, TEM-102
Antimicrob. Agents Chemother. 2003 47: 2572-2578. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kristin H. Dahl and Arnfinn Sundsfjord

Transferable vanB2 Tn5382-Containing Elements in Fecal Streptococcal Strains from Veal Calves
Antimicrob. Agents Chemother. 2003 47: 2579-2583. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anne Beauchef-Havard, Guillaume Arlet, Valerie Gautier, Roger Labia, Patrick Grimont, and Alain Philippon

Molecular and Biochemical Characterization of a Novel Class A ß-Lactamase (HER-1) from Escherichia hermannii
Antimicrob. Agents Chemother. 2003 47: 2669-2673. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

María-Isabel Morosini, Elena Loza, Rosa del Campo, Felisa Almaraz, Fernando Baquero, and Rafael Cantón

Fluoroquinolone-Resistant Streptococcus pneumoniae in Spain: Activities of Garenoxacin against Clinical Isolates Including Strains with Altered Topoisomerases
Antimicrob. Agents Chemother. 2003 47: 2692-2695. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ronald N. Jones, David J. Farrell, and Ian Morrissey

Quinupristin-Dalfopristin Resistance in Streptococcus pneumoniae: Novel L22 Ribosomal Protein Mutation in Two Clinical Isolates from the SENTRY Antimicrobial Surveillance Program
Antimicrob. Agents Chemother. 2003 47: 2696-2698. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Jan Lycke, Clas Malmeström, and Lars Ståhle

Acyclovir Levels in Serum and Cerebrospinal Fluid after Oral Administration of Valacyclovir
Antimicrob. Agents Chemother. 2003 47: 2438-2441. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Barry R. O'Keefe, Donald F. Smee, Jim A. Turpin, Carrie J. Saucedo, Kirk R. Gustafson, Toshiyuki Mori, Dennis Blakeslee, Robert Buckheit, and Michael R. Boyd

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin
Antimicrob. Agents Chemother. 2003 47: 2518-2525. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Wendy K. Foster, Darren S. Miller, Patricia L. Marion, Richard J. Colonno, Ieva Kotlarski, and Allison R. Jilbert

Entecavir Therapy Combined with DNA Vaccination for Persistent Duck Hepatitis B Virus Infection
Antimicrob. Agents Chemother. 2003 47: 2624-2635. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Weidong Zhong, Haoyun An, Dinesh Barawkar, and Zhi Hong

Dinucleotide Analogues as Novel Inhibitors of RNA-Dependent RNA Polymerase of Hepatitis C Virus
Antimicrob. Agents Chemother. 2003 47: 2674-2681. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Agostina Pietrantoni, Assunta Maria Di Biase, Antonella Tinari, Magda Marchetti, Piera Valenti, Lucilla Seganti, and Fabiana Superti

Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides
Antimicrob. Agents Chemother. 2003 47: 2688-2691. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Michael H. Cynamon and Mary Sklaney

Gatifloxacin and Ethionamide as the Foundation for Therapy of Tuberculosis
Antimicrob. Agents Chemother. 2003 47: 2442-2444. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Evangelos J. Giamarellos-Bourboulis, Helen Poulaki, Nikolaos Kostomitsopoulos, Ismene Dontas, Despina Perrea, Panayotis E. Karayannacos, and Helen Giamarellou

Effective Immunomodulatory Treatment of Escherichia coli Experimental Sepsis with Thalidomide
Antimicrob. Agents Chemother. 2003 47: 2445-2449. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

F. Kühn, M. Cottagnoud, F. Acosta, L. Flatz, J. Entenza, and P. Cottagnoud

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro
Antimicrob. Agents Chemother. 2003 47: 2487-2491. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alexander A. Padiglione, Rory Wolfe, Elizabeth A. Grabsch, Di Olden, Stephen Pearson, Clare Franklin, Denis Spelman, Barrie Mayall, Paul D. R. Johnson, and M. Lindsay Grayson

Risk Factors for New Detection of Vancomycin-Resistant Enterococci in Acute-Care Hospitals That Employ Strict Infection Control Procedures
Antimicrob. Agents Chemother. 2003 47: 2492-2498. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jenny Dahl Knudsen, Inga Odenholt, Helga Erlendsdottir, Magnus Gottfredsson, Otto Cars, Niels Frimodt-Møller, Frank Espersen, Karl G. Kristinsson, and Sigurdur Gudmundsson

Selection of Resistant Streptococcus pneumoniae during Penicillin Treatment In Vitro and in Three Animal Models
Antimicrob. Agents Chemother. 2003 47: 2499-2506. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Masakatsu Tsuji, Morio Takema, Hideaki Miwa, Jingoro Shimada, and Shogo Kuwahara

In Vivo Antibacterial Activity of S-3578, a New Broad-Spectrum Cephalosporin: Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Experimental Infection Models
Antimicrob. Agents Chemother. 2003 47: 2507-2512. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Henry W. Murray, Elaine B. Brooks, Jennifer L. DeVecchio, and Frederick P. Heinzel

Immunoenhancement Combined with Amphotericin B as Treatment for Experimental Visceral Leishmaniasis
Antimicrob. Agents Chemother. 2003 47: 2513-2517. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marie L. Ancelin, Michèle Calas, Anne Bonhoure, Serge Herbute, and Henri J. Vial

In Vivo Antimalarial Activities of Mono- and Bis Quaternary Ammonium Salts Interfering with Plasmodium Phospholipid Metabolism
Antimicrob. Agents Chemother. 2003 47: 2598-2605. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

George P. Allen, Glenn W. Kaatz, and Michael J. Rybak

Activities of Mutant Prevention Concentration-Targeted Moxifloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model
Antimicrob. Agents Chemother. 2003 47: 2606-2614. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Natsuko Takakura, Hiroyuki Wakabayashi, Hiroko Ishibashi, Susumu Teraguchi, Yoshitaka Tamura, Hideyo Yamaguchi, and Shigeru Abe

Oral Lactoferrin Treatment of Experimental Oral Candidiasis in Mice
Antimicrob. Agents Chemother. 2003 47: 2619-2623. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Annette Spreer, Holger Kerstan, Tobias Böttcher, Joachim Gerber, Alexander Siemer, Gregor Zysk, Timothy J. Mitchell, Helmut Eiffert, and Roland Nau

Reduced Release of Pneumolysin by Streptococcus pneumoniae In Vitro and In Vivo after Treatment with Nonbacteriolytic Antibiotics in Comparison to Ceftriaxone
Antimicrob. Agents Chemother. 2003 47: 2649-2654. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Charlene F. Dailey, Paul J. Pagano, Lewis V. Buchanan, Jennifer A. Paquette, Joseph V. Haas, and John K. Gibson

Efficacy of Linezolid plus Rifampin in an Experimental Model of Methicillin-Susceptible Staphylococcus aureus Endocarditis
Antimicrob. Agents Chemother. 2003 47: 2655-2658. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Luiz E. Bermudez, Robert Reynolds, Peter Kolonoski, Pricilla Aralar, Clark B. Inderlied, and Lowell S. Young

Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice
Antimicrob. Agents Chemother. 2003 47: 2685-2687. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Suresh R. Pai, Kavindra V. Singh, and Barbara E. Murray

In Vivo Efficacy of the Ketolide ABT-773 (Cethromycin) against Enterococci in a Mouse Peritonitis Model
Antimicrob. Agents Chemother. 2003 47: 2706-2709. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Keith A. Rodvold, Larry H. Danziger, and Mark H. Gotfried

Steady-State Plasma and Bronchopulmonary Concentrations of Intravenous Levofloxacin and Azithromycin in Healthy Adults
Antimicrob. Agents Chemother. 2003 47: 2450-2457. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chin-Chung Lin, Kenneth Luu, David Lourenco, and Li-Tain Yeh

Pharmacokinetics and Metabolism of [¹⁴C]Viramidine in Rats and Cynomolgus Monkeys
Antimicrob. Agents Chemother. 2003 47: 2458-2463. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Aleksander Patrzykat, Jeffrey W. Gallant, Jung-Kil Seo, Jennifer Pytyck, and Susan E. Douglas

Novel Antimicrobial Peptides Derived from Flatfish Genes
Antimicrob. Agents Chemother. 2003 47: 2464-2470. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yutaka Ueda and Makoto Sunagawa

In Vitro and In Vivo Activities of Novel 2-(Thiazol-2-ylthio)-1ß-Methylcarbapenems with Potent Activities against Multiresistant Gram-Positive Bacteria
Antimicrob. Agents Chemother. 2003 47: 2471-2480. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Woong Sik Jang, Chong Han Kim, Kyu Nam Kim, Shin Yong Park, Joon Ha Lee, Seok Min Son, and In Hee Lee

Biological Activities of Synthetic Analogs of Halocidin, an Antimicrobial Peptide from the Tunicate Halocynthia aurantium
Antimicrob. Agents Chemother. 2003 47: 2481-2486. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marie L. Ancelin, Michèle Calas, Valérie Vidal-Sailhan, Serge Herbuté, Pascal Ringwald, and Henri J. Vial

Potent Inhibitors of Plasmodium Phospholipid Metabolism with a Broad Spectrum of In Vitro Antimalarial Activities
Antimicrob. Agents Chemother. 2003 47: 2590-2597. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Conor E. Jamieson, Peter A. Lambert, and Iain N. Simpson

In Vitro Activities of Novel Oxapenems, Alone and in Combination with Ceftazidime, against Gram-Positive and Gram-Negative Organisms
Antimicrob. Agents Chemother. 2003 47: 2615-2618. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sevtap Arikan, Pinar Yurdakul, and Gulsen Hascelik

Comparison of Two Methods and Three End Points in Determination of In Vitro Activity of Micafungin against Aspergillus spp.
Antimicrob. Agents Chemother. 2003 47: 2640-2643. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Emilia Cercenado, Sonia Cercenado, and Emilio Bouza

In Vitro Activities of Tigecycline (GAR-936) and 12 Other Antimicrobial Agents against 90 Eikenella corrodens Clinical Isolates
Antimicrob. Agents Chemother. 2003 47: 2644-2645. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Duane R. Hospenthal and Clinton K. Murray

In Vitro Susceptibilities of Seven Leptospira Species to Traditional and Newer Antibiotics
Antimicrob. Agents Chemother. 2003 47: 2646-2648. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

George A. Syrogiannopoulos, Ioanna N. Grivea, Lois M. Ednie, Bülent Bozdogan, George D. Katopodis, Nicholas G. Beratis, Todd A. Davies, and Peter C. Appelbaum

Antimicrobial Susceptibility and Macrolide Resistance Inducibility of Streptococcus pneumoniae Carrying erm(A), erm(B), or mef(A)
Antimicrob. Agents Chemother. 2003 47: 2699-2702. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Saskia Priebe and Stefan Schwarz

In Vitro Activities of Florfenicol against Bovine and Porcine Respiratory Tract Pathogens
Antimicrob. Agents Chemother. 2003 47: 2703-2705. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

John P. Ouderkirk, Jill A. Nord, Glenn S. Turett, and Jay Ward Kislak

Polymyxin B Nephrotoxicity and Efficacy against Nosocomial Infections Caused by Multiresistant Gram-Negative Bacteria
Antimicrob. Agents Chemother. 2003 47: 2659-2662. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael W. Dunne, Chandra Khurana, Adriano Arguedas Mohs, Adib Rodriguez, Antonio Arrieta, Samuel McLinn, Judy A. Krogstad, Mark Blatter, Richard Schwartz, Sergio L. Vargas, Paz Emparanza, Pilar Fernandez, Willis M. Gooch, III, Mary Aspin, John Podgore, Irmeli Roine, Jeffrey L. Blumer, Garth D. Ehrlich, and Jean Chow

Efficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis
Antimicrob. Agents Chemother. 2003 47: 2663-2665. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

P. S. Grutkoski, C. T. Graeber, Y. P. Lim, A. Ayala, and H. H. Simms

-Defensin 1 (Human Neutrophil Protein 1) as an Antichemotactic Agent for Human Polymorphonuclear Leukocytes
Antimicrob. Agents Chemother. 2003 47: 2666-2668. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Anja M. Werno, Trevor P. Anderson, and David R. Murdoch

Antimicrobial Susceptibilities of Group B Streptococci in New Zealand
Antimicrob. Agents Chemother. 2003 47: 2710-2711. [Full Text] [PDF] [Reprints and Permissions]  

Steven R. Meshnick, Richard K. Haynes, Diego Monti, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, and Piero Olliaro

Artemisinin and Heme
Antimicrob. Agents Chemother. 2003 47: 2712-2713. [Full Text] [PDF] [Reprints and Permissions]  

Emanuele Nicastri, Loredana Sarmati, Massimo Andreoni, Saverio G. Parisi, Martin Stürmer, Hans-Wilhelm Doerr, Schlomo Staszewski, and Kurt Hertogs

Human Immunodeficiency Virus Polymorphisms and Zidovudine Resistance
Antimicrob. Agents Chemother. 2003 47: 2714-2715. [Full Text] [PDF] [Reprints and Permissions]  

Errata:

George G. Zhanel, Lorraine Palatnick, Kimberly A. Nichol, Tracy Bellyou, Don E. Low, and Daryl J. Hoban

Antimicrobial Resistance in Respiratory Tract Streptococcus pneumoniae Isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002
Antimicrob. Agents Chemother. 2003 47: 2716. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.