Contents: August 2003, Volume 47, Issue 8        Minireviews        Mechanisms of Action        Mechanisms of Resistance        Antiviral Agents        Experimental Therapeutics        Pharmacology        Susceptibility        Clinical Therapeutics        Biologic Response Modifiers        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Ambler Class A Extended-Spectrum ß-Lactamases in Pseudomonas aeruginosa: Novel Developments and Clinical Impact Gerhard F. Weldhagen, Laurent Poirel, and Patrice Nordmann Antimicrob. Agents Chemother. August 2003 47: 2385-2392; [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Reversal of Mefloquine and Quinine Resistance in Plasmodium falciparum with NP30 Michelle Ciach, Kathleen Zong, Kevin C. Kain, and Ian Crandall Antimicrob. Agents Chemother. August 2003 47: 2393-2396; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones David R. Macinga, Paul J. Renick, Kelly M. Makin, David H. Ellis, Allison A. Kreiner, Min Li, Kirk J. Rupnik, Erica M. Kincaid, Cynthia D. Wallace, Benoit Ledoussal, and Timothy W. Morris Antimicrob. Agents Chemother. August 2003 47: 2526-2537; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Correlation of Daptomycin Bactericidal Activity and Membrane Depolarization in Staphylococcus aureus Jared A. Silverman, Nancy G. Perlmutter, and Howard M. Shapiro Antimicrob. Agents Chemother. August 2003 47: 2538-2544; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Subinhibitory Concentrations of the Deformylase Inhibitor Actinonin Increase Bacterial Release of Neutrophil-Activating Peptides: a New Approach to Antimicrobial Chemotherapy Huamei Fu, Claes Dahlgren, and Johan Bylund Antimicrob. Agents Chemother. August 2003 47: 2545-2550; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums Giancarlo A. Biagini, Eric Richier, Patrick G. Bray, Michèle Calas, Henri Vial, and Stephen A. Ward Antimicrob. Agents Chemother. August 2003 47: 2584-2589; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of 25 Quinolones and Fluoroquinolones against Liver and Blood Stage Plasmodium spp. Nassira Mahmoudi, Liliane Ciceron, Jean-François Franetich, Khemais Farhati, Olivier Silvie, Wijnand Eling, Robert Sauerwein, Martin Danis, Dominique Mazier, and Francis Derouin Antimicrob. Agents Chemother. August 2003 47: 2636-2639; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Bactericidal Activities of Daptomycin against Staphylococcus aureus and Enterococcus faecalis Are Not Mediated by Inhibition of Lipoteichoic Acid Biosynthesis Valerie Laganas, Jeffrey Alder, and Jared A. Silverman Antimicrob. Agents Chemother. August 2003 47: 2682-2684; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Leishmania donovani Resistance to Miltefosine Involves a Defective Inward Translocation of the Drug F. Javier Pérez-Victoria, Santiago Castanys, and Francisco Gamarro Antimicrob. Agents Chemother. August 2003 47: 2397-2403; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Candida albicans Mutations in the Ergosterol Biosynthetic Pathway and Resistance to Several Antifungal Agents Dominique Sanglard, Françoise Ischer, Tania Parkinson, Derek Falconer, and Jacques Bille Antimicrob. Agents Chemother. August 2003 47: 2404-2412; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Cloning and Characterization of an ABC Multidrug Efflux Pump, VcaM, in Non-O1 Vibrio cholerae Nazmul Huda, Eun-Woo Lee, Jing Chen, Yuji Morita, Teruo Kuroda, Tohru Mizushima, and Tomofusa Tsuchiya Antimicrob. Agents Chemother. August 2003 47: 2413-2417; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1 Amy L. Pickard, Chansuda Wongsrichanalai, Anne Purfield, Deborah Kamwendo, Kathryn Emery, Christy Zalewski, Fumihiko Kawamoto, R. Scott Miller, and Steven R. Meshnick Antimicrob. Agents Chemother. August 2003 47: 2418-2423; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Mechanisms of Itraconazole Resistance in Candida dubliniensis Emmanuelle Pinjon, Gary P. Moran, Colin J. Jackson, Steven L. Kelly, Dominique Sanglard, David C. Coleman, and Derek J. Sullivan Antimicrob. Agents Chemother. August 2003 47: 2424-2437; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Haemophilus influenzae blaROB-1 Mutations in Hypermutagenic ampC Escherichia coli Conferring Resistance to Cefotaxime and ß-Lactamase Inhibitors and Increased Susceptibility to Cefaclor Juan-Carlos Galán, María-Isabel Morosini, María-Rosario Baquero, Milagro Reig, and Fernando Baquero Antimicrob. Agents Chemother. August 2003 47: 2551-2557; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

MsrR, a Putative Cell Envelope-Associated Element Involved in Staphylococcus aureus sarA Attenuation Jutta Rossi, Markus Bischoff, Akihito Wada, and Brigitte Berger-Bächi Antimicrob. Agents Chemother. August 2003 47: 2558-2564; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated High-Level Resistance to Aminoglycosides in Enterobacteriaceae Due to 16S rRNA Methylation Marc Galimand, Patrice Courvalin, and Thierry Lambert Antimicrob. Agents Chemother. August 2003 47: 2565-2571; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum ß-Lactamases in Ireland, Including a Novel Enzyme, TEM-102 Dearbháile Morris, Colette O'Hare, Maura Glennon, Majella Maher, Geraldine Corbett-Feeney, and Martin Cormican Antimicrob. Agents Chemother. August 2003 47: 2572-2578; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transferable vanB2 Tn5382-Containing Elements in Fecal Streptococcal Strains from Veal Calves Kristin H. Dahl and Arnfinn Sundsfjord Antimicrob. Agents Chemother. August 2003 47: 2579-2583; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular and Biochemical Characterization of a Novel Class A ß-Lactamase (HER-1) from Escherichia hermannii Anne Beauchef-Havard, Guillaume Arlet, Valerie Gautier, Roger Labia, Patrick Grimont, and Alain Philippon Antimicrob. Agents Chemother. August 2003 47: 2669-2673; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone-Resistant Streptococcus pneumoniae in Spain: Activities of Garenoxacin against Clinical Isolates Including Strains with Altered Topoisomerases María-Isabel Morosini, Elena Loza, Rosa del Campo, Felisa Almaraz, Fernando Baquero, and Rafael Cantón Antimicrob. Agents Chemother. August 2003 47: 2692-2695; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinupristin-Dalfopristin Resistance in Streptococcus pneumoniae: Novel L22 Ribosomal Protein Mutation in Two Clinical Isolates from the SENTRY Antimicrobial Surveillance Program Ronald N. Jones, David J. Farrell, and Ian Morrissey Antimicrob. Agents Chemother. August 2003 47: 2696-2698; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Acyclovir Levels in Serum and Cerebrospinal Fluid after Oral Administration of Valacyclovir Jan Lycke, Clas Malmeström, and Lars Ståhle Antimicrob. Agents Chemother. August 2003 47: 2438-2441; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin Barry R. O'Keefe, Donald F. Smee, Jim A. Turpin, Carrie J. Saucedo, Kirk R. Gustafson, Toshiyuki Mori, Dennis Blakeslee, Robert Buckheit, and Michael R. Boyd Antimicrob. Agents Chemother. August 2003 47: 2518-2525; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Entecavir Therapy Combined with DNA Vaccination for Persistent Duck Hepatitis B Virus Infection Wendy K. Foster, Darren S. Miller, Patricia L. Marion, Richard J. Colonno, Ieva Kotlarski, and Allison R. Jilbert Antimicrob. Agents Chemother. August 2003 47: 2624-2635; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dinucleotide Analogues as Novel Inhibitors of RNA-Dependent RNA Polymerase of Hepatitis C Virus Weidong Zhong, Haoyun An, Dinesh Barawkar, and Zhi Hong Antimicrob. Agents Chemother. August 2003 47: 2674-2681; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides Agostina Pietrantoni, Assunta Maria Di Biase, Antonella Tinari, Magda Marchetti, Piera Valenti, Lucilla Seganti, and Fabiana Superti Antimicrob. Agents Chemother. August 2003 47: 2688-2691; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Gatifloxacin and Ethionamide as the Foundation for Therapy of Tuberculosis Michael H. Cynamon and Mary Sklaney Antimicrob. Agents Chemother. August 2003 47: 2442-2444; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effective Immunomodulatory Treatment of Escherichia coli Experimental Sepsis with Thalidomide Evangelos J. Giamarellos-Bourboulis, Helen Poulaki, Nikolaos Kostomitsopoulos, Ismene Dontas, Despina Perrea, Panayotis E. Karayannacos, and Helen Giamarellou Antimicrob. Agents Chemother. August 2003 47: 2445-2449; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro F. Kühn, M. Cottagnoud, F. Acosta, L. Flatz, J. Entenza, and P. Cottagnoud Antimicrob. Agents Chemother. August 2003 47: 2487-2491; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Risk Factors for New Detection of Vancomycin-Resistant Enterococci in Acute-Care Hospitals That Employ Strict Infection Control Procedures Alexander A. Padiglione, Rory Wolfe, Elizabeth A. Grabsch, Di Olden, Stephen Pearson, Clare Franklin, Denis Spelman, Barrie Mayall, Paul D. R. Johnson, and M. Lindsay Grayson Antimicrob. Agents Chemother. August 2003 47: 2492-2498; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection of Resistant Streptococcus pneumoniae during Penicillin Treatment In Vitro and in Three Animal Models Jenny Dahl Knudsen, Inga Odenholt, Helga Erlendsdottir, Magnus Gottfredsson, Otto Cars, Niels Frimodt-Møller, Frank Espersen, Karl G. Kristinsson, and Sigurdur Gudmundsson Antimicrob. Agents Chemother. August 2003 47: 2499-2506; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Antibacterial Activity of S-3578, a New Broad-Spectrum Cephalosporin: Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Experimental Infection Models Masakatsu Tsuji, Morio Takema, Hideaki Miwa, Jingoro Shimada, and Shogo Kuwahara Antimicrob. Agents Chemother. August 2003 47: 2507-2512; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Immunoenhancement Combined with Amphotericin B as Treatment for Experimental Visceral Leishmaniasis Henry W. Murray, Elaine B. Brooks, Jennifer L. DeVecchio, and Frederick P. Heinzel Antimicrob. Agents Chemother. August 2003 47: 2513-2517; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Antimalarial Activities of Mono- and Bis Quaternary Ammonium Salts Interfering with Plasmodium Phospholipid Metabolism Marie L. Ancelin, Michèle Calas, Anne Bonhoure, Serge Herbute, and Henri J. Vial Antimicrob. Agents Chemother. August 2003 47: 2598-2605; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Mutant Prevention Concentration-Targeted Moxifloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model George P. Allen, Glenn W. Kaatz, and Michael J. Rybak Antimicrob. Agents Chemother. August 2003 47: 2606-2614; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral Lactoferrin Treatment of Experimental Oral Candidiasis in Mice Natsuko Takakura, Hiroyuki Wakabayashi, Hiroko Ishibashi, Susumu Teraguchi, Yoshitaka Tamura, Hideyo Yamaguchi, and Shigeru Abe Antimicrob. Agents Chemother. August 2003 47: 2619-2623; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Release of Pneumolysin by Streptococcus pneumoniae In Vitro and In Vivo after Treatment with Nonbacteriolytic Antibiotics in Comparison to Ceftriaxone Annette Spreer, Holger Kerstan, Tobias Böttcher, Joachim Gerber, Alexander Siemer, Gregor Zysk, Timothy J. Mitchell, Helmut Eiffert, and Roland Nau Antimicrob. Agents Chemother. August 2003 47: 2649-2654; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Linezolid plus Rifampin in an Experimental Model of Methicillin-Susceptible Staphylococcus aureus Endocarditis Charlene F. Dailey, Paul J. Pagano, Lewis V. Buchanan, Jennifer A. Paquette, Joseph V. Haas, and John K. Gibson Antimicrob. Agents Chemother. August 2003 47: 2655-2658; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice Luiz E. Bermudez, Robert Reynolds, Peter Kolonoski, Pricilla Aralar, Clark B. Inderlied, and Lowell S. Young Antimicrob. Agents Chemother. August 2003 47: 2685-2687; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy of the Ketolide ABT-773 (Cethromycin) against Enterococci in a Mouse Peritonitis Model Suresh R. Pai, Kavindra V. Singh, and Barbara E. Murray Antimicrob. Agents Chemother. August 2003 47: 2706-2709; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Steady-State Plasma and Bronchopulmonary Concentrations of Intravenous Levofloxacin and Azithromycin in Healthy Adults Keith A. Rodvold, Larry H. Danziger, and Mark H. Gotfried Antimicrob. Agents Chemother. August 2003 47: 2450-2457; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Metabolism of [14C]Viramidine in Rats and Cynomolgus Monkeys Chin-Chung Lin, Kenneth Luu, David Lourenco, and Li-Tain Yeh Antimicrob. Agents Chemother. August 2003 47: 2458-2463; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Novel Antimicrobial Peptides Derived from Flatfish Genes Aleksander Patrzykat, Jeffrey W. Gallant, Jung-Kil Seo, Jennifer Pytyck, and Susan E. Douglas Antimicrob. Agents Chemother. August 2003 47: 2464-2470; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Novel 2-(Thiazol-2-ylthio)-1ß-Methylcarbapenems with Potent Activities against Multiresistant Gram-Positive Bacteria Yutaka Ueda and Makoto Sunagawa Antimicrob. Agents Chemother. August 2003 47: 2471-2480; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biological Activities of Synthetic Analogs of Halocidin, an Antimicrobial Peptide from the Tunicate Halocynthia aurantium Woong Sik Jang, Chong Han Kim, Kyu Nam Kim, Shin Yong Park, Joon Ha Lee, Seok Min Son, and In Hee Lee Antimicrob. Agents Chemother. August 2003 47: 2481-2486; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent Inhibitors of Plasmodium Phospholipid Metabolism with a Broad Spectrum of In Vitro Antimalarial Activities Marie L. Ancelin, Michèle Calas, Valérie Vidal-Sailhan, Serge Herbuté, Pascal Ringwald, and Henri J. Vial Antimicrob. Agents Chemother. August 2003 47: 2590-2597; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Novel Oxapenems, Alone and in Combination with Ceftazidime, against Gram-Positive and Gram-Negative Organisms Conor E. Jamieson, Peter A. Lambert, and Iain N. Simpson Antimicrob. Agents Chemother. August 2003 47: 2615-2618; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Two Methods and Three End Points in Determination of In Vitro Activity of Micafungin against Aspergillus spp. Sevtap Arikan, Pinar Yurdakul, and Gulsen Hascelik Antimicrob. Agents Chemother. August 2003 47: 2640-2643; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Tigecycline (GAR-936) and 12 Other Antimicrobial Agents against 90 Eikenella corrodens Clinical Isolates Emilia Cercenado, Sonia Cercenado, and Emilio Bouza Antimicrob. Agents Chemother. August 2003 47: 2644-2645; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Seven Leptospira Species to Traditional and Newer Antibiotics Duane R. Hospenthal and Clinton K. Murray Antimicrob. Agents Chemother. August 2003 47: 2646-2648; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility and Macrolide Resistance Inducibility of Streptococcus pneumoniae Carrying erm(A), erm(B), or mef(A) George A. Syrogiannopoulos, Ioanna N. Grivea, Lois M. Ednie, Bülent Bozdogan, George D. Katopodis, Nicholas G. Beratis, Todd A. Davies, and Peter C. Appelbaum Antimicrob. Agents Chemother. August 2003 47: 2699-2702; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Florfenicol against Bovine and Porcine Respiratory Tract Pathogens Saskia Priebe and Stefan Schwarz Antimicrob. Agents Chemother. August 2003 47: 2703-2705; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Polymyxin B Nephrotoxicity and Efficacy against Nosocomial Infections Caused by Multiresistant Gram-Negative Bacteria John P. Ouderkirk, Jill A. Nord, Glenn S. Turett, and Jay Ward Kislak Antimicrob. Agents Chemother. August 2003 47: 2659-2662; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis Michael W. Dunne, Chandra Khurana, Adriano Arguedas Mohs, Adib Rodriguez, Antonio Arrieta, Samuel McLinn, Judy A. Krogstad, Mark Blatter, Richard Schwartz, Sergio L. Vargas, Paz Emparanza, Pilar Fernandez, Willis M. Gooch, III, Mary Aspin, John Podgore, Irmeli Roine, Jeffrey L. Blumer, Garth D. Ehrlich, and Jean Chow Antimicrob. Agents Chemother. August 2003 47: 2663-2665; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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-Defensin 1 (Human Neutrophil Protein 1) as an Antichemotactic Agent for Human Polymorphonuclear Leukocytes P. S. Grutkoski, C. T. Graeber, Y. P. Lim, A. Ayala, and H. H. Simms Antimicrob. Agents Chemother. August 2003 47: 2666-2668; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Antimicrobial Susceptibilities of Group B Streptococci in New Zealand Anja M. Werno, Trevor P. Anderson, and David R. Murdoch Antimicrob. Agents Chemother. August 2003 47: 2710-2711; [Full Text] [PDF] [Reprints and Permissions]

Artemisinin and Heme Steven R. Meshnick, Richard K. Haynes, Diego Monti, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, and Piero Olliaro Antimicrob. Agents Chemother. August 2003 47: 2712-2713; [Full Text] [PDF] [Reprints and Permissions]

Human Immunodeficiency Virus Polymorphisms and Zidovudine Resistance Emanuele Nicastri, Loredana Sarmati, Massimo Andreoni, Saverio G. Parisi, Martin Stürmer, Hans-Wilhelm Doerr, Schlomo Staszewski, and Kurt Hertogs Antimicrob. Agents Chemother. August 2003 47: 2714-2715; [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Antimicrobial Resistance in Respiratory Tract Streptococcus pneumoniae Isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002 George G. Zhanel, Lorraine Palatnick, Kimberly A. Nichol, Tracy Bellyou, Don E. Low, and Daryl J. Hoban Antimicrob. Agents Chemother. August 2003 47: 2716 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.