Contents: September 2003, Volume 47, Issue 9        Mechanisms of Resistance        Experimental Therapeutics        Clinical Therapeutics        Pharmacology        Biologic Response Modifiers        Susceptibility        Antiviral Agents        Chemistry; Biosynthesis        Mechanisms of Action        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Resistance:

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Disruption of Ergosterol Biosynthesis Confers Resistance to Amphotericin B in Candida lusitaniae Laura Y. Young, Christina M. Hull, and Joseph Heitman Antimicrob. Agents Chemother. September 2003 47: 2717-2724; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci Philip Hill, Jacques Kessl, Nicholas Fisher, Steven Meshnick, Bernard L. Trumpower, and Brigitte Meunier Antimicrob. Agents Chemother. September 2003 47: 2725-2731; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Analysis of incHI1 Antimicrobial Resistance Plasmids from Salmonella Serovar Typhi Strains Associated with Typhoid Fever John Wain, L. T. Diem Nga, Claire Kidgell, Keith James, Sarah Fortune, To Song Diep, Tahir Ali, Peadar Ó Gaora, Christopher Parry, Julian Parkhill, Jeremy Farrar, Nicholas J. White, and Gordon Dougan Antimicrob. Agents Chemother. September 2003 47: 2732-2739; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of AcrR and RamA in Fluoroquinolone Resistance in Clinical Klebsiella pneumoniae Isolates from Singapore T. Schneiders, S. G. B. Amyes, and S. B. Levy Antimicrob. Agents Chemother. September 2003 47: 2831-2837; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of a New Class 3 Integron in Klebsiella pneumoniae Mário Correia, Filipa Boavida, Filipa Grosso, M. J. Salgado, L. M. Lito, J. Melo Cristino, Sónia Mendo, and Aida Duarte Antimicrob. Agents Chemother. September 2003 47: 2838-2843; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Presence of the tet(O) Gene in Erythromycin- and Tetracycline-Resistant Strains of Streptococcus pyogenes and Linkage with either the mef(A) or the erm(A) Gene Eleonora Giovanetti, Andrea Brenciani, Remo Lupidi, Marilyn C. Roberts, and Pietro E. Varaldo Antimicrob. Agents Chemother. September 2003 47: 2844-2849; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biological Costs and Mechanisms of Fosfomycin Resistance in Escherichia coli Annika I. Nilsson, Otto G. Berg, Olle Aspevall, Gunnar Kahlmeter, and Dan I. Andersson Antimicrob. Agents Chemother. September 2003 47: 2850-2858; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular and Biochemical Characterization of OXA-45, an Extended-Spectrum Class 2d' ß-Lactamase in Pseudomonas aeruginosa Mark A. Toleman, Kenneth Rolston, Ronald N. Jones, and Timothy R. Walsh Antimicrob. Agents Chemother. September 2003 47: 2859-2863; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum ß-Lactamases in Enterobacteriaceae in Buenos Aires, Argentina, Public Hospitals M. Quinteros, M. Radice, N. Gardella, M. M. Rodriguez, N. Costa, D. Korbenfeld, E. Couto, and G. Gutkind Antimicrob. Agents Chemother. September 2003 47: 2864-2867; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance to the Peptidyl Transferase Inhibitor Tiamulin Caused by Mutation of Ribosomal Protein L3 Jacob Bøsling, Susan M. Poulsen, Birte Vester, and Katherine S. Long Antimicrob. Agents Chemother. September 2003 47: 2892-2896; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Aminoglycoside 6'-N-Acetyltransferase Type Ib Encoded by Tn1331 Is Evenly Distributed within the Cell's Cytoplasm Ken J. Dery, Britta Søballe, Mavee S. L. Witherspoon, Duyen Bui, Robert Koch, David J. Sherratt, and Marcelo E. Tolmasky Antimicrob. Agents Chemother. September 2003 47: 2897-2902; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Klebsiella oxytoca ß-Lactamase Genes blaOXY-3 and blaOXY-4 and a Third Genetic Group of K. oxytoca Based on blaOXY-3 Sophie A. Granier, Véronique Leflon-Guibout, Fred W. Goldstein, and Marie-Hélène Nicolas-Chanoine Antimicrob. Agents Chemother. September 2003 47: 2922-2928; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Insertion Sequence ISEcp1B Is Involved in Expression and Mobilization of a blaCTX-M ß-Lactamase Gene Laurent Poirel, Jean-Winoc Decousser, and Patrice Nordmann Antimicrob. Agents Chemother. September 2003 47: 2938-2945; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Plasmid-Borne Antibiotic Resistance Gene Cluster in Pasteurella multocida Corinna Kehrenberg, Nga Thi Thu Tham, and Stefan Schwarz Antimicrob. Agents Chemother. September 2003 47: 2978-2980; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New TEM-Derived Extended-Spectrum ß-Lactamase (TEM-91) with an R164C Substitution at the -Loop Confers Ceftazidime Resistance Hiroshi Kurokawa, Naohiro Shibata, Yohei Doi, Keigo Shibayama, Kazunari Kamachi, Tetsuya Yagi, and Yoshichika Arakawa Antimicrob. Agents Chemother. September 2003 47: 2981-2983; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori Monique M. Gerrits, Marco Berning, Arnoud H. M. Van Vliet, Ernst J. Kuipers, and Johannes G. Kusters Antimicrob. Agents Chemother. September 2003 47: 2984-2986; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Cloning and Characterization of a Multidrug Efflux Pump, MexHI-OpmD, from a Pseudomonas aeruginosa Mutant Hiroshi Sekiya, Takehiko Mima, Yuji Morita, Teruo Kuroda, Tohru Mizushima, and Tomofusa Tsuchiya Antimicrob. Agents Chemother. September 2003 47: 2990-2992; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Antibiotic Resistance Gene Transfer from Animal to Human Enterococci in the Digestive Tract of Gnotobiotic Mice C. Moubareck, N. Bourgeois, P. Courvalin, and F. Doucet-Populaire Antimicrob. Agents Chemother. September 2003 47: 2993-2996; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Pseudomonas aeruginosa Gene That Suppresses Tolerance to Carbapenems Kazuko Taniguchi, Tsuneko Ono, Keiji Murakami, Darija Viducic, Sizuo Kayama, Katsuhiko Hirota, Ken Nemoto, and Yoichiro Miyake Antimicrob. Agents Chemother. September 2003 47: 2997-3001; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to ß-Lactams Kunihiko Nishino, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata, and Akihito Yamaguchi Antimicrob. Agents Chemother. September 2003 47: 3030-3033; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Real-Time Monitoring of Bacterial Infection In Vivo: Development of Bioluminescent Staphylococcal Foreign-Body and Deep-Thigh-Wound Mouse Infection Models Nelly A. Kuklin, Gregory D. Pancari, Timothy W. Tobery, Leslie Cope, Jesse Jackson, Charles Gill, Karen Overbye, Kevin P. Francis, Jun Yu, Donna Montgomery, Annaliesa S. Anderson, William McClements, and Kathrin U. Jansen Antimicrob. Agents Chemother. September 2003 47: 2740-2748; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Levofloxacin and Ciprofloxacin in a Murine Pneumonia Model: Peak Concentration/MIC versus Area under the Curve/MIC Ratios F. Scaglione, J. W. Mouton, R. Mattina, and F. Fraschini Antimicrob. Agents Chemother. September 2003 47: 2749-2755; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Linezolid Alone or in Combination with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus Fu-Yu Chiang and Michael Climo Antimicrob. Agents Chemother. September 2003 47: 3002-3004; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemotherapeutic Potential of Orally Administered Poly(Lactide-Co-Glycolide) Microparticles Containing Isoniazid, Rifampin, and Pyrazinamide against Experimental Tuberculosis Qurrat ul-Ain, Sadhna Sharma, and G. K. Khuller Antimicrob. Agents Chemother. September 2003 47: 3005-3007; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Effectiveness of Combination Antimicrobial Therapy for Pseudomonas aeruginosa Bacteremia Eric Chamot, Emmanuelle Boffi El Amari, Peter Rohner, and Christian Van Delden Antimicrob. Agents Chemother. September 2003 47: 2756-2764; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Azithromycin Administration for Trachoma Control on the Carriage of Antibiotic-Resistant Streptococcus pneumoniae Sarah L. Batt, Bambos M. Charalambous, Anthony W. Solomon, Charles Knirsch, Patrick A. Massae, Salesia Safari, Noel E. Sam, Dean Everett, David C. W. Mabey, and Stephen H. Gillespie Antimicrob. Agents Chemother. September 2003 47: 2765-2769; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Randomized Double-Blind Study Comparing 3- and 6-Day Regimens of Azithromycin with a 10-Day Amoxicillin-Clavulanate Regimen for Treatment of Acute Bacterial Sinusitis Dan C. Henry, Ernie Riffer, William N. Sokol, Naumann I. Chaudry, and Robert N. Swanson Antimicrob. Agents Chemother. September 2003 47: 2770-2774; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Epidemiological Risk Factors for Isolation of Ceftriaxone-Resistant versus -Susceptible Citrobacter freundii in Hospitalized Patients Peter W. Kim, Anthony D. Harris, Mary-Claire Roghmann, J. Glenn Morris, Jr., Arjun Strinivasan, and Eli N. Perencevich Antimicrob. Agents Chemother. September 2003 47: 2882-2887; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sulfadoxine-Pyrimethamine in Treatment of Malaria in Western Kenya: Increasing Resistance and Underdosing Dianne J. Terlouw, Bernard L. Nahlen, Jeanne M. Courval, Simon K. Kariuki, Oren S. Rosenberg, Aggrey J. Oloo, Margarette S. Kolczak, William A. Hawley, Altaf A. Lal, and Feiko O. ter Kuile Antimicrob. Agents Chemother. September 2003 47: 2929-2932; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacokinetics of Linezolid in Subjects with Renal Dysfunction Michael E. Brier, Dennis J. Stalker, George R. Aronoff, Donald H. Batts, Kristi K. Ryan, Margaret O'Grady, Nancy K. Hopkins, and Gail L. Jungbluth Antimicrob. Agents Chemother. September 2003 47: 2775-2780; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics, Toxicities, and Efficacies of Sodium Stibogluconate Formulations after Intravenous Administration in Animals J. Nieto, J. Alvar, A. B. Mullen, K. C. Carter, C. Rodríguez, M. I. San Andrés, M. D. San Andrés, A. J. Baillie, and F. González Antimicrob. Agents Chemother. September 2003 47: 2781-2787; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics, Safety, and Tolerability of Oral Posaconazole Administered in Single and Multiple Doses in Healthy Adults Rachel Courtney, Sudhakar Pai, Mark Laughlin, Josephine Lim, and Vijay Batra Antimicrob. Agents Chemother. September 2003 47: 2788-2795; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Optimal Sampling Schedule Design for Populations of Patients Vincent H. Tam, Sandra L. Preston, and G. L. Drusano Antimicrob. Agents Chemother. September 2003 47: 2888-2891; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Measurement of Cefaclor and Amoxicillin-Clavulanic Acid Levels in Middle-Ear Fluid in Patients with Acute Otitis Media F. Scaglione, D. Caronzolo, J. P. Pintucci, and F. Fraschini Antimicrob. Agents Chemother. September 2003 47: 2987-2989; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Association of the Endotoxin Antagonist E5564 with High-Density Lipoproteins In Vitro: Dependence on Low-Density and Triglyceride-Rich Lipoprotein Concentrations Kishor M. Wasan, Olena Sivak, Richard A. Cote, Aaron I. MacInnes, Kathy D. Boulanger, Melvyn Lynn, William J. Christ, Lynn D. Hawkins, and Daniel P. Rossignol Antimicrob. Agents Chemother. September 2003 47: 2796-2803; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Antimicrobial Characterization of Human ß-Defensin 3 Derivatives David M. Hoover, Zhibin Wu, Kenneth Tucker, Wuyuan Lu, and Jacek Lubkowski Antimicrob. Agents Chemother. September 2003 47: 2804-2809; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of New Fluoroquinolones against Campylobacter jejuni and Campylobacter coli Isolates Obtained from Humans in 1980 to 1982 and 1997 to 2001 Rea Krausse and Uwe Ullmann Antimicrob. Agents Chemother. September 2003 47: 2946-2950; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discordant Resistance to Kanamycin and Amikacin in Drug-Resistant Mycobacterium tuberculosis Annika Krüüner, Pontus Jureen, Klavdia Levina, Solomon Ghebremichael, and Sven Hoffner Antimicrob. Agents Chemother. September 2003 47: 2971-2973; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Daptomycin against Recent North American Isolates of Streptococcus pneumoniae M. I. Restrepo, J. A. Velez, M. L. McElmeel, C. G. Whitney, and J. H. Jorgensen Antimicrob. Agents Chemother. September 2003 47: 2974-2977; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of ABT-492, a New Fluoroquinolone, against 155 Aerobic and 171 Anaerobic Pathogens Isolated from Antral Sinus Puncture Specimens from Patients with Sinusitis Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, and Helen T. Fernandez Antimicrob. Agents Chemother. September 2003 47: 3008-3011; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effects of Daptomycin against 14 Staphylococcal and Pneumococcal Clinical Isolates G. A. Pankuch, M. R. Jacobs, and P. C. Appelbaum Antimicrob. Agents Chemother. September 2003 47: 3012-3014; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions Elizabeth Nenortas, Tomasz Kulikowicz, Christian Burri, and Theresa A. Shapiro Antimicrob. Agents Chemother. September 2003 47: 3015-3017; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Disk Diffusion-Based Methods for Determining Candida parapsilosis Susceptibility to Anidulafungin Zekaver Odabasi, Victor Paetznick, Beth P. Goldstein, John H. Rex, and Luis Ostrosky-Zeichner Antimicrob. Agents Chemother. September 2003 47: 3018-3020; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of a New Lipopeptide, HMR 1043, against Susceptible and Resistant Gram-Positive Isolates Pascale Bemer, Marie-Emmanuelle Juvin, Andre Bryskier, and Henri Drugeon Antimicrob. Agents Chemother. September 2003 47: 3025-3029; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1 Xin Chen, Lu Yang, Ning Zhang, Jim A. Turpin, Robert W. Buckheit, Clay Osterling, Joost J. Oppenheim, and O. M. Zack Howard Antimicrob. Agents Chemother. September 2003 47: 2810-2816; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Hypersusceptibility of Human Immunodeficiency Virus Type 1 Subtype C Protease to Lopinavir Luis M. F. Gonzalez, Rodrigo M. Brindeiro, Michelle Tarin, Alexandre Calazans, Marcelo A. Soares, Sharon Cassol, and Amilcar Tanuri Antimicrob. Agents Chemother. September 2003 47: 2817-2822; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Effects of Geranylgeranylacetone: Enhancement of MxA Expression and Phosphorylation of PKR during Influenza Virus Infection Masako Unoshima, Hideo Iwasaka, Junko Eto, Yoshiko Takita-Sonoda, Takayuki Noguchi, and Akira Nishizono Antimicrob. Agents Chemother. September 2003 47: 2914-2921; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aerosolized Cidofovir Is Retained in the Respiratory Tract and Protects Mice against Intranasal Cowpox Virus Challenge Chad J. Roy, Robert Baker, Kenneth Washburn, and Mike Bray Antimicrob. Agents Chemother. September 2003 47: 2933-2937; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives Miguel Stevens, Christophe Pannecouque, Erik De Clercq, and Jan Balzarini Antimicrob. Agents Chemother. September 2003 47: 2951-2957; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Real-Time PCR as a Versatile Tool for Investigating the Susceptibility of Human Herpesvirus 6 to Antiviral Agents Muriel Macé, Chaysavanh Manichanh, Pascale Bonnafous, Stéphanie Précigout, David Boutolleau, Agnès Gautheret-Dejean, and Henri Agut Antimicrob. Agents Chemother. September 2003 47: 3021-3024; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Deciphering Tuberactinomycin Biosynthesis: Isolation, Sequencing, and Annotation of the Viomycin Biosynthetic Gene Cluster Michael G. Thomas, Yolande A. Chan, and Sarah G. Ozanick Antimicrob. Agents Chemother. September 2003 47: 2823-2830; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Microcin C51 Plasmid Genes: Possible Source of Horizontal Gene Transfer Dmitri E. Fomenko, Anastazia Z. Metlitskaya, Jean Péduzzi, Christophe Goulard, Genrikh S. Katrukha, Leonid V. Gening, Sylvie Rebuffat, and Inessa A. Khmel Antimicrob. Agents Chemother. September 2003 47: 2868-2874; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Intracellular Expression of Peptide Fusions for Demonstration of Protein Essentiality in Bacteria R. Edward Benson, Elizabeth B. Gottlin, Dale J. Christensen, and Paul T. Hamilton Antimicrob. Agents Chemother. September 2003 47: 2875-2881; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Signature Gene Expression Profiles Discriminate between Isoniazid-, Thiolactomycin-, and Triclosan-Treated Mycobacterium tuberculosis Joanna C. Betts, Alistair McLaren, Mark G. Lennon, Fiona M. Kelly, Pauline T. Lukey, Steve J. Blakemore, and Ken Duncan Antimicrob. Agents Chemother. September 2003 47: 2903-2913; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Ser130Gly and Asp240Lys Substitutions in Extended-Spectrum ß-Lactamase CTX-M-9 C. Aumeran, C. Chanal, R. Labia, D. Sirot, J. Sirot, and R. Bonnet Antimicrob. Agents Chemother. September 2003 47: 2958-2961; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gentamicin Delivery to Burkholderia cepacia Group IIIa Strains via Membrane Vesicles from Pseudomonas aeruginosa PAO1 Nick D. Allan and Terry J. Beveridge Antimicrob. Agents Chemother. September 2003 47: 2962-2965; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

S-Adenosyl-L-Methionine Inhibitors 24-Sterol Methyltransferase and 24(28)-Sterol Methylreductase as Possible Agents against Paracoccidioides brasiliensis Gonzalo Visbal, Alvaro Alvarez, Belisario Moreno, and Gioconda San-Blas Antimicrob. Agents Chemother. September 2003 47: 2966-2970; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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VIM-4 in a Carbapenem-Resistant Strain of Pseudomonas aeruginosa Isolated in Sweden Christian G. Giske, Margareta Rylander, and Göran Kronvall Antimicrob. Agents Chemother. September 2003 47: 3034-3035; [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Antitrypanosomal Activities of Proteasome Inhibitors Njinkeng Joseph Nkemngu, Vera Rosenkranz, Michael Wink, and Dietmar Steverding Antimicrob. Agents Chemother. September 2003 47: 3036 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.