AAC -- Table of Contents (November 1 2004, 48 [11])

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Contents: November 2004, Volume 48, Issue 11

       Minireviews

       Susceptibility

       Mechanisms of Resistance

       Chemistry; Biosynthesis

       Experimental Therapeutics

       Antiviral Agents

       Clinical Therapeutics

       Pharmacology

       Mechanisms of Action

       Letters

Other Issues

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Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Minireviews:

Chloroquine Resistance in Plasmodium vivax
J. Kevin Baird
Antimicrob. Agents Chemother. November 2004 48: 4075-4083;
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Susceptibility:

In Vitro Testing of Antimicrobial Activity of Bone Cement
Volker Alt, Thorsten Bechert, Peter Steinrücke, Michael Wagener, Peter Seidel, Elvira Dingeldein, Eugen Domann, and Reinhard Schnettler
Antimicrob. Agents Chemother. November 2004 48: 4084-4088;
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Synergism between Amodiaquine and Its Major Metabolite, Desethylamodiaquine, against Plasmodium falciparum In Vitro
S. T. Mariga, J. P. Gil, C. Sisowath, W. H. Wernsdorfer, and A. Björkman
Antimicrob. Agents Chemother. November 2004 48: 4089-4096;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Modified Fixed-Ratio Isobologram Method for Studying In Vitro Interactions between Atovaquone and Proguanil or Dihydroartemisinin against Drug-Resistant Strains of Plasmodium falciparum
Quinton L. Fivelman, Ipemida S. Adagu, and David C. Warhurst
Antimicrob. Agents Chemother. November 2004 48: 4097-4102;
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Activities of Two Novel Macrolides, GW 773546 and GW 708408, Compared with Those of Telithromycin, Erythromycin, Azithromycin, and Clarithromycin against Haemophilus influenzae
Klaudia Kosowska, Kim Credito, Glenn A. Pankuch, Dianne Hoellman, Gengrong Lin, Catherine Clark, Bonifacio Dewasse, Pamela McGhee, Michael R. Jacobs, and Peter C. Appelbaum
Antimicrob. Agents Chemother. November 2004 48: 4113-4119;
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Inhibition of Antibiotic Efflux in Bacteria by the Novel Multidrug Resistance Inhibitors Biricodar (VX-710) and Timcodar (VX-853)
Steve Mullin, Nagraj Mani, and Trudy H. Grossman
Antimicrob. Agents Chemother. November 2004 48: 4171-4176;
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Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds
Melanie T. Cushion, Peter D. Walzer, Margaret S. Collins, Sandra Rebholz, Jean Jacques Vanden Eynde, Annie Mayence, and Tien L. Huang
Antimicrob. Agents Chemother. November 2004 48: 4209-4216;
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Evolution of the Antimicrobial Resistance of Staphylococcus spp. in Spain: Five Nationwide Prevalence Studies, 1986 to 2002
Oscar Cuevas, Emilia Cercenado, Ana Vindel, Jesús Guinea, Matilde Sánchez-Conde, Mar Sánchez-Somolinos, Emilio Bouza the Spanish Group for the Study of Staphylococcus
Antimicrob. Agents Chemother. November 2004 48: 4240-4245;
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Activity of OPT-80, a Novel Macrocycle, Compared with Those of Eight Other Agents against Selected Anaerobic Species
Kim L. Credito and Peter C. Appelbaum
Antimicrob. Agents Chemother. November 2004 48: 4430-4434;
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Altered Susceptibility of Candida glabrata Bloodstream Isolates to Triazoles at Clinically Relevant pH Values: Comparison of the NCCLS M27-A2, Sensititre YeastOne, and Etest Methods
Manjunath P. Pai and Ariel L. Jones
Antimicrob. Agents Chemother. November 2004 48: 4441-4443;
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Antibiotic Susceptibility in Neonatal Invasive Isolates of Streptococcus agalactiae in a 2-Year Nationwide Surveillance Study in Germany
Kirsten Fluegge, Sven Supper, Anette Siedler, and Reinhard Berner
Antimicrob. Agents Chemother. November 2004 48: 4444-4446;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial and Antileishmanial Activities of Hypocrellins A and B
Guoyi Ma, Shabana I. Khan, Melissa R. Jacob, Babu L. Tekwani, Zuqiang Li, David S. Pasco, Larry A. Walker, and Ikhlas A. Khan
Antimicrob. Agents Chemother. November 2004 48: 4450-4452;
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Evaluation of a Colorimetric Antifungal Susceptibility Test by Using 2,3-Diphenyl-5-Thienyl-(2)-Tetrazolium Chloride
Jeong Hwan Shin, Jae-Cheol Choi, Jeong Nyeo Lee, Hyung Hoi Kim, Eun Yup Lee, and Chulhun Ludgerus Chang
Antimicrob. Agents Chemother. November 2004 48: 4457-4459;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility Patterns among Viridans Group Streptococcal Isolates from Infective Endocarditis Patients from 1971 to 1986 and 1994 to 2002
Rajesh M. Prabhu, Kerryl E. Piper, Larry M. Baddour, James M. Steckelberg, Walter R. Wilson, and Robin Patel
Antimicrob. Agents Chemother. November 2004 48: 4463-4465;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Mycoplasma hyopneumoniae Field Isolates
J. Vicca, T. Stakenborg, D. Maes, P. Butaye, J. Peeters, A. de Kruif, and F. Haesebrouck
Antimicrob. Agents Chemother. November 2004 48: 4470-4472;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Tigecycline (GAR-936) against Acinetobacter baumannii Strains, Including Those Resistant to Imipenem
María Eugenia Pachón-Ibáñez, Manuel Enrique Jiménez-Mejías, Cristina Pichardo, Ana Cristina Llanos, and Jerónimo Pachón
Antimicrob. Agents Chemother. November 2004 48: 4479-4481;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

Antipneumococcal Activities of Two Novel Macrolides, GW 773546 and GW 708408, Compared with Those of Erythromycin, Azithromycin, Clarithromycin, Clindamycin, and Telithromycin
Vlatka Matic, Klaudia Kosowska, Bulent Bozdogan, Linda M. Kelly, Kathy Smith, Lois M. Ednie, Gengrong Lin, Kim L. Credito, Catherine L. Clark, Pamela McGhee, Glenn A. Pankuch, Michael R. Jacobs, and Peter C. Appelbaum
Antimicrob. Agents Chemother. November 2004 48: 4103-4112;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Multidrug-Resistant Salmonella enterica Serovar Typhi in Korea
Kyungwon Lee, Dongeun Yong, Jong Hwa Yum, Young Sik Lim, Hyun Sook Kim, Bok Kwon Lee, and Yunsop Chong
Antimicrob. Agents Chemother. November 2004 48: 4130-4135;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Four Variants of the Citrobacter freundii AmpC-Type Cephalosporinases, Including Novel Enzymes CMY-14 and CMY-15, in a Proteus mirabilis Clone Widespread in Poland
Elzbieta Literacka, Joanna Empel, Anna Baraniak, Ewa Sadowy, Waleria Hryniewicz, and Marek Gniadkowski
Antimicrob. Agents Chemother. November 2004 48: 4136-4143;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidrug Resistance of a Porin Deletion Mutant of Mycobacterium smegmatis
Joachim Stephan, Claudia Mailaender, Gilles Etienne, Mamadou Daffé, and Michael Niederweis
Antimicrob. Agents Chemother. November 2004 48: 4163-4170;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Promoter Sequences Necessary for High-Level Expression of the Plasmid-Associated ampC ß-Lactamase Gene bla_MIR-1
Mark D. Reisbig and Nancy D. Hanson
Antimicrob. Agents Chemother. November 2004 48: 4177-4182;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

OXA-60, a Chromosomal, Inducible, and Imipenem-Hydrolyzing Class D ß-Lactamase from Ralstonia pickettii
Delphine Girlich, Thierry Naas, and Patrice Nordmann
Antimicrob. Agents Chemother. November 2004 48: 4217-4225;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hypermutation and the Preexistence of Antibiotic-Resistant Pseudomonas aeruginosa Mutants: Implications for Susceptibility Testing and Treatment of Chronic Infections
Antonio Oliver, Bruce R. Levin, Carlos Juan, Fernando Baquero, and Jesús Blázquez
Antimicrob. Agents Chemother. November 2004 48: 4226-4233;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Complex Multiple Antibiotic and Mercury Resistance Region Derived from the r-det of NR1 (R100)
Sally R. Partridge and Ruth M. Hall
Antimicrob. Agents Chemother. November 2004 48: 4250-4255;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Infections with Nontyphoidal Salmonella Species Producing TEM-63 or a Novel TEM Enzyme, TEM-131, in South Africa
Tersia Kruger, Dora Szabo, Karen H. Keddy, Kathleen Deeley, Jane W. Marsh, Andrea M. Hujer, Robert A. Bonomo, and David L. Paterson
Antimicrob. Agents Chemother. November 2004 48: 4263-4270;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Heterologous Expression of the Enterococcal vanA Operon in Methicillin-Resistant Staphylococcus aureus
Bruno Périchon and Patrice Courvalin
Antimicrob. Agents Chemother. November 2004 48: 4281-4285;
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Rapid Direct Detection of Multiple Rifampin and Isoniazid Resistance Mutations in Mycobacterium tuberculosis in Respiratory Samples by Real-Time PCR
Mercedes Marín, Darío García de Viedma, María Jesús Ruíz-Serrano, and Emilio Bouza
Antimicrob. Agents Chemother. November 2004 48: 4293-4300;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations of Pneumocystis jirovecii Dihydrofolate Reductase Associated with Failure of Prophylaxis
Aimable Nahimana, Meja Rabodonirina, Jacques Bille, Patrick Francioli, and Philippe M. Hauser
Antimicrob. Agents Chemother. November 2004 48: 4301-4305;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques
Julian Gregston Hurdle, Alexander John O'Neill, Eileen Ingham, Colin Fishwick, and Ian Chopra
Antimicrob. Agents Chemother. November 2004 48: 4366-4376;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Mechanisms of Primary Resistance to Flucytosine in Candida albicans
William W. Hope, Lydia Tabernero, David W. Denning, and Michael J. Anderson
Antimicrob. Agents Chemother. November 2004 48: 4377-4386;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Evolution of Itraconazole Resistance in Aspergillus fumigatus Involves Multiple Mechanisms of Resistance
Márcia Eliana da Silva Ferreira, José Luiz Capellaro, Everaldo dos Reis Marques, Iran Malavazi, David Perlin, Steven Park, James B. Anderson, Arnaldo L. Colombo, Beth A. Arthington-Skaggs, Maria Helena S. Goldman, and Gustavo H. Goldman
Antimicrob. Agents Chemother. November 2004 48: 4405-4413;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Community-Onset Disease Caused by Citrobacter freundii Producing a Novel CTX-M ß-Lactamase, CTX-M-30, in Canada
Baha Abdalhamid, Johann D. D. Pitout, Ellen S. Moland, and Nancy D. Hanson
Antimicrob. Agents Chemother. November 2004 48: 4435-4437;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated Carbapenem-Hydrolyzing Enzyme KPC-2 in an Enterobacter sp.
Ashfaque Hossain, M. J. Ferraro, R. M. Pino, R. B. Dew, III, E. S. Moland, T. J. Lockhart, K. S. Thomson, R. V. Goering, and N. D. Hanson
Antimicrob. Agents Chemother. November 2004 48: 4438-4440;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Mutations within the embB Gene in Ethambutol-Susceptible Clinical Isolates of Mycobacterium tuberculosis
Ann S. G. Lee, Siti Noor Khadijah Othman, Yu Min Ho, and Sin Yew Wong
Antimicrob. Agents Chemother. November 2004 48: 4447-4449;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinolone-Resistant Haemophilus influenzae: Determination of Mutant Selection Window for Ciprofloxacin, Garenoxacin, Levofloxacin, and Moxifloxacin
Xinying Li, Noriel Mariano, James J. Rahal, Carl M. Urban, and Karl Drlica
Antimicrob. Agents Chemother. November 2004 48: 4460-4462;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

SHV-49, a Novel Inhibitor-Resistant ß-Lactamase in a Clinical Isolate of Klebsiella pneumoniae
Véronique Dubois, Laurent Poirel, Corinne Arpin, Laure Coulange, Cécile Bebear, Patrice Nordmann, and Claudine Quentin
Antimicrob. Agents Chemother. November 2004 48: 4466-4469;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemistry; Biosynthesis:

Chemical Diversity of Polyene Macrolides Produced by Streptomyces noursei ATCC 11455 and Recombinant Strain ERD44 with Genetically Altered Polyketide Synthase NysC
Per Bruheim, Sven E.F. Borgos, Pascale Tsan, Håvard Sletta, Trond E. Ellingsen, Jean-Marc Lancelin, and Sergey B. Zotchev
Antimicrob. Agents Chemother. November 2004 48: 4120-4129;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Effects of Amoxicillin Subinhibitory Concentrations on the Cross-Protection Developed by Pneumococcal Antibodies in Mouse Sepsis Caused by an Amoxicillin-Resistant Serotype 6B Streptococcus pneumoniae Strain
D. Tarragó, L. Aguilar, M. J. Giménez, A. Fenoll, and J. Casal
Antimicrob. Agents Chemother. November 2004 48: 4144-4147;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of the New Triazole Derivative Albaconazole against Trypanosoma (Schizotrypanum) cruzi in Dog Hosts
Paulo Marcos da Matta Guedes, Julio A. Urbina, Marta de Lana, Luis C. C. Afonso, Vanja M. Veloso, Washington L. Tafuri, George L. L. Machado-Coelho, Egler Chiari, and Maria Terezinha Bahia
Antimicrob. Agents Chemother. November 2004 48: 4286-4292;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

LB11058, a New Cephalosporin with High Penicillin-Binding Protein 2a Affinity and Activity in Experimental Endocarditis Due to Homogeneously Methicillin-Resistant Staphylococcus aureus
Jacques Vouillamoz, José M. Entenza, Peter Hohl, and Philippe Moreillon
Antimicrob. Agents Chemother. November 2004 48: 4322-4327;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Aspergillus fumigatus Efficacy of Pentraxin 3 Alone and in Combination with Antifungals
Roberta Gaziano, Silvia Bozza, Silvia Bellocchio, Katia Perruccio, Claudia Montagnoli, Lucia Pitzurra, Giovanni Salvatori, Rita De Santis, Paolo Carminati, Alberto Mantovani, and Luigina Romani
Antimicrob. Agents Chemother. November 2004 48: 4414-4421;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Pharmacodynamic Characteristics of Amphotericin B, Caspofungin, Fluconazole, and Voriconazole against Bloodstream Isolates of Infrequent Candida Species from Patients with Hematologic Malignancies
Giovanni Di Bonaventura, Ilaria Spedicato, Carla Picciani, Domenico D'Antonio, and Raffaele Piccolomini
Antimicrob. Agents Chemother. November 2004 48: 4453-4456;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Ceftazidime plus the Serine ß-Lactamase Inhibitor AM-112 against Escherichia coli Containing TEM-1 and CTX-M-1 ß-Lactamases
Karen E. Bowker, Alan R. Noel, Timothy R. Walsh, Chris A. Rogers, and Alasdair P. MacGowan
Antimicrob. Agents Chemother. November 2004 48: 4482-4484;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Simultaneous Splenic Sample PCR with Blood Sample PCR for Diagnosis and Treatment of Experimental Ehrlichia canis Infection
Shimon Harrus, Martin Kenny, Limor Miara, Itzhak Aizenberg, Trevor Waner, and Susan Shaw
Antimicrob. Agents Chemother. November 2004 48: 4488-4490;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Nevirapine Significantly Reduces the Levels of Racemic Methadone and (R)-Methadone in Human Immunodeficiency Virus-Infected Patients
Hartmut Stocker, Guido Kruse, Peter Kreckel, Christian Herzmann, Keikawus Arastéh, Jörg Claus, Heiko Jessen, Christiane Cordes, Bettina Hintsche, Frank Schlote, Lothar Schneider, and Michael Kurowski
Antimicrob. Agents Chemother. November 2004 48: 4148-4153;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Chemical Class of pUL97 Protein Kinase-Specific Inhibitors with Strong Anticytomegaloviral Activity
Thomas Herget, Martina Freitag, Monika Morbitzer, Regina Kupfer, Thomas Stamminger, and Manfred Marschall
Antimicrob. Agents Chemother. November 2004 48: 4154-4162;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Maintenance of the M184V Substitution in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 by Various Nucleoside Antiretroviral Agents in Tissue Culture
Marco Petrella, Maureen Oliveira, Daniela Moisi, Mervi Detorio, Bluma G. Brenner, and Mark A. Wainberg
Antimicrob. Agents Chemother. November 2004 48: 4189-4194;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Indinavir and Ritonavir Administered at 667 and 100 Milligrams, Respectively, Every 12 Hours Compared with Indinavir Administered at 800 Milligrams Every 8 Hours in Human Immunodeficiency Virus-Infected Patients
Frank S. Rhame, Sandy L. Rawlins, Richard A. Petruschke, Tara A. Erb, Gregory A. Winchell, Helene M. Wilson, Jonathan M. Edelman, and Murray A. Abramson
Antimicrob. Agents Chemother. November 2004 48: 4200-4208;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Steady-State Pharmacokinetics of a Double-Boosting Regimen of Saquinavir Soft Gel plus Lopinavir plus Minidose Ritonavir in Human Immunodeficiency Virus-Infected Adults
Esteban Ribera, Rosa M. Lopez, Marjorie Diaz, Leonor Pou, Lidia Ruiz, Vicenç Falcó, Manuel Crespo, Carlos Azuaje, Isabel Ruiz, Imma Ocaña, Bonaventura Clotet, and Albert Pahissa
Antimicrob. Agents Chemother. November 2004 48: 4256-4262;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Valproic Acid Coadministration on Plasma Efavirenz and Lopinavir Concentrations in Human Immunodeficiency Virus-Infected Adults
Robert DiCenzo, Derick Peterson, Kim Cruttenden, Gene Morse, Garret Riggs, Harris Gelbard, and Giovanni Schifitto
Antimicrob. Agents Chemother. November 2004 48: 4328-4331;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Maternal-Fetal Transfer and Amniotic Fluid Accumulation of Nucleoside Analogue Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pregnant Women
Hélène Chappuy, Jean-Marc Tréluyer, Vincent Jullien, Jérôme Dimet, Elisabeth Rey, Maria Fouché, Ghislaine Firtion, Gérard Pons, and Laurent Mandelbrot
Antimicrob. Agents Chemother. November 2004 48: 4332-4336;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Delivery of Granulocyte-Macrophage Colony-Stimulating Factor in Bioadhesive Hydrogel Stimulates Migration of Dendritic Cells in Models of Human Papillomavirus-Associated (Pre)Neoplastic Epithelial Lesions
Pascale Hubert, Brigitte Evrard, Catherine Maillard, Elizabeth Franzen-Detrooz, Luc Delattre, Jean-Michel Foidart, Agnes Noël, Jacques Boniver, and Philippe Delvenne
Antimicrob. Agents Chemother. November 2004 48: 4342-4348;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion
Shibo Jiang, Hong Lu, Shuwen Liu, Qian Zhao, Yuxian He, and Asim K. Debnath
Antimicrob. Agents Chemother. November 2004 48: 4349-4359;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Combination of Amdoxovir and the Inosine Monophosphate Dehydrogenase Inhibitors Mycophenolic Acid and Ribavirin Demonstrates Potent Activity against Wild-Type and Drug-Resistant Variants of Human Immunodeficiency Virus Type 1
Katyna Borroto-Esoda, Florence Myrick, Joy Feng, Jerry Jeffrey, and Phillip Furman
Antimicrob. Agents Chemother. November 2004 48: 4387-4394;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Emergence and Persistence of Macrolide Resistance in Oropharyngeal Flora and Elimination of Nasal Carriage of Staphylococcus aureus after Therapy with Slow-Release Clarithromycin: a Randomized, Double-Blind, Placebo-Controlled Study
Hans F. Berg, Jeroen H. T. Tjhie, Gert-Jan Scheffer, Marcel F. Peeters, Peter H. J. van Keulen, Jan A. J. W. Kluytmans, and Ellen E. Stobberingh
Antimicrob. Agents Chemother. November 2004 48: 4183-4188;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Assessment of Drug Efficacy against Plasmodium falciparum Malaria: Duration of Follow-Up
Kasia Stepniewska, Walter R.J. Taylor, Mayfong Mayxay, Ric Price, Frank Smithuis, Jean-Paul Guthmann, Karen Barnes, Hla Yin Myint, Martin Adjuik, Piero Olliaro, Sasithon Pukrittayakamee, Sornchai Looareesuwan, Tran Tinh Hien, Jeremy Farrar, François Nosten, Nicholas P.J. Day, and Nicholas J. White
Antimicrob. Agents Chemother. November 2004 48: 4271-4280;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evidence for Biliary Excretion of Vancomycin into Stool during Intravenous Therapy: Potential Implications for Rectal Colonization with Vancomycin-Resistant Enterococci
Brian P. Currie and Luciano Lemos-Filho
Antimicrob. Agents Chemother. November 2004 48: 4427-4429;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Indinavir at 800, 600, and 400 Milligrams Administered with Ritonavir at 100 Milligrams and Efavirenz in Ethnic Chinese Patients Infected with Human Immunodeficiency Virus
Lawrence S. Lee, Anushia Panchalingam, Marline C. Yap, and Nicholas I. Paton
Antimicrob. Agents Chemother. November 2004 48: 4476-4478;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Pharmacodynamics of Pulse Dosing versus Standard Dosing: In Vitro Metronidazole Activity against Bacteroides fragilis and Bacteroides thetaiotaomicron
Khalid H. Ibrahim, Brent W. Gunderson, Elizabeth D. Hermsen, Laurie B. Hovde, and John C. Rotschafer
Antimicrob. Agents Chemother. November 2004 48: 4195-4199;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Pharmacokinetics of Intramuscular Artesunate and Artemether in Patients with Severe Falciparum Malaria
T. T. Hien, T. M. E. Davis, L. V. Chuong, K. F. Ilett, D. X. T. Sinh, N. H. Phu, C. Agus, G. M. Chiswell, N. J. White, and J. Farrar
Antimicrob. Agents Chemother. November 2004 48: 4234-4239;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Concentrations of Gemifloxacin at the Target Site in Healthy Volunteers after a Single Oral Dose
Florian Islinger, Rene Bouw, Mathias Stahl, Edith Lackner, Petra Zeleny, Martin Brunner, Markus Müller, Hans Georg Eichler, and Christian Joukhadar
Antimicrob. Agents Chemother. November 2004 48: 4246-4249;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potential for Interactions between Caspofungin and Nelfinavir or Rifampin
Julie A. Stone, Elizabeth M. Migoya, Lisa Hickey, Gregory A. Winchell, Paul J. Deutsch, Kalyan Ghosh, Amanda Freeman, Sheng Bi, Rajesh Desai, Stacy C. Dilzer, Kenneth C. Lasseter, Walter K. Kraft, Howard Greenberg, and Scott A. Waldman
Antimicrob. Agents Chemother. November 2004 48: 4306-4314;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Approach to Characterization of Combined Pharmacodynamic Effects of Antimicrobial Agents
Vincent H. Tam, Amy N. Schilling, Russell E. Lewis, David A. Melnick, and Adam N. Boucher
Antimicrob. Agents Chemother. November 2004 48: 4315-4321;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dose-Dependent Resorption of Quinine after Intrarectal Administration to Children with Moderate Plasmodium falciparum Malaria
Eric Pussard, Celine Straczek, Idrissa Kaboré, Auguste Bicaba, Tatiana Balima-Koussoube, Patrice Bouree, and Hubert Barennes
Antimicrob. Agents Chemother. November 2004 48: 4422-4426;
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Decreased Bioavailability of Rifampin and Other Antituberculosis Drugs in Patients with Advanced Human Immunodeficiency Virus Disease
Prema Gurumurthy, Geetha Ramachandran, A. K. Hemanth Kumar, S. Rajasekaran, C. Padmapriyadarsini, Soumya Swaminathan, S. Bhagavathy, P. Venkatesan, L. Sekar, A. Mahilmaran, N. Ravichandran, and P. Paramesh
Antimicrob. Agents Chemother. November 2004 48: 4473-4475;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nonisotopic, Semiautomated Plasmodium falciparum Bioassay for Measurement of Antimalarial Drug Levels in Serum or Plasma
Harald Noedl, Paktiya Teja-Isavadharm, and Robert Scott Miller
Antimicrob. Agents Chemother. November 2004 48: 4485-4487;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Inhibition of Adherence and Killing of Candida albicans with a 23-Mer Peptide (Fn/23) with Dual Antifungal Properties
Stephen A. Klotz, Nand K. Gaur, Jason Rauceo, Douglas F. Lake, Y. Park, K. S. Hahm, and Peter N. Lipke
Antimicrob. Agents Chemother. November 2004 48: 4337-4341;
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Usnic Acid, a Natural Antimicrobial Agent Able To Inhibit Bacterial Biofilm Formation on Polymer Surfaces
I. Francolini, P. Norris, A. Piozzi, G. Donelli, and P. Stoodley
Antimicrob. Agents Chemother. November 2004 48: 4360-4365;
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Platelet Microbicidal Protein 1: Structural Themes of a Multifunctional Antimicrobial Peptide
Nannette Y. Yount, Kimberly D. Gank, Yan Qiong Xiong, Arnold S. Bayer, Thomas Pender, William H. Welch, and Michael R. Yeaman
Antimicrob. Agents Chemother. November 2004 48: 4395-4404;
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Letters:

The Echinocandin "Target" Identified by Cross-Linking Is a Homolog of Pil1 and Lsp1, Sphingolipid-Dependent Regulators of Cell Wall Integrity Signaling
Thomas D. Edlind and Santosh K. Katiyar
Antimicrob. Agents Chemother. November 2004 48: 4491
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First Report of Salmonella Isolates with the DHA-1 AmpC ß-Lactamase in the United Kingdom
E. Liebana, M. Batchelor, F. A. Clifton-Hadley, R. H. Davies, K. L. Hopkins, and E. J. Threlfall
Antimicrob. Agents Chemother. November 2004 48: 4492
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Uncommon Association of T69 3-Base-Pair Insertion Plus Q151M Multidrug Resistance Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
Catherine Tamalet, Mireille Henry, Philippe Colson, Nouara Yahi, Cecile Poggi, and Alain Lafeuillade
Antimicrob. Agents Chemother. November 2004 48: 4493-4494;
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