AAC -- Table of Contents (December 1 2004, 48 [12])

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Contents: December 2004, Volume 48, Issue 12

       Mechanisms of Resistance

       Experimental Therapeutics

       Susceptibility

       Clinical Therapeutics

       Pharmacology

       Antiviral Agents

       Mechanisms of Action

       Chemistry; Biosynthesis

       Letters

       Errata

Other Issues

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Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Mechanisms of Resistance:

A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II
Thomas Gruger, John L. Nitiss, Anthony Maxwell, E. Lynn Zechiedrich, Peter Heisig, Siegfried Seeber, Yves Pommier, and Dirk Strumberg
Antimicrob. Agents Chemother. December 2004 48: 4495-4504;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

CaNdt80 Is Involved in Drug Resistance in Candida albicans by Regulating CDR1
Chia-Geun Chen, Yun-Liang Yang, Hsin-I Shih, Chia-Li Su, and Hsiu-Jung Lo
Antimicrob. Agents Chemother. December 2004 48: 4505-4512;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

TEM-121, a Novel Complex Mutant of TEM-Type ß-Lactamase from Enterobacter aerogenes
Laurent Poirel, Hedi Mammeri, and Patrice Nordmann
Antimicrob. Agents Chemother. December 2004 48: 4528-4531;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of CTX-M-Type ß-Lactamase Genes in Fecal Escherichia coli Isolates from Healthy Children in Bolivia and Peru
Lucia Pallecchi, Monica Malossi, Antonia Mantella, Eduardo Gotuzzo, Christian Trigoso, Alessandro Bartoloni, Franco Paradisi, Göran Kronvall, and Gian Maria Rossolini
Antimicrob. Agents Chemother. December 2004 48: 4556-4561;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penicillin-Binding Protein 2 Is Essential for Expression of High-Level Vancomycin Resistance and Cell Wall Synthesis in Vancomycin- Resistant Staphylococcus aureus Carrying the Enterococcal vanA Gene Complex
Anatoly Severin, Shang Wei Wu, Keiko Tabei, and Alexander Tomasz
Antimicrob. Agents Chemother. December 2004 48: 4566-4573;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization and Molecular Analysis of Macrolide-Resistant Mycoplasma pneumoniae Clinical Isolates Obtained in Japan
Mayumi Matsuoka, Mitsuo Narita, Norio Okazaki, Hitomi Ohya, Tsutomu Yamazaki, Kazunobu Ouchi, Isao Suzuki, Tomoaki Andoh, Tsuyoshi Kenri, Yuko Sasaki, Atsuko Horino, Miharu Shintani, Yoshichika Arakawa, and Tsuguo Sasaki
Antimicrob. Agents Chemother. December 2004 48: 4624-4630;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Cloning of Bacillus anthracis Dihydrofolate Reductase and Confirmation of Natural Resistance to Trimethoprim
Esther W. Barrow, Philip C. Bourne, and William W. Barrow
Antimicrob. Agents Chemother. December 2004 48: 4643-4649;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of a ß-Lactamase Gene, bla_GIM-1, Encoding a New Subclass of Metallo-ß-Lactamase
Mariana Castanheira, Mark A. Toleman, Ronald N. Jones, Franz J. Schmidt, and Timothy R. Walsh
Antimicrob. Agents Chemother. December 2004 48: 4654-4661;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus-Derived Proteinases
Magdalena Sieprawska-Lupa, Piotr Mydel, Katarzyna Krawczyk, Kinga Wójcik, Magdalena Puklo, Boguslaw Lupa, Piotr Suder, Jerzy Silberring, Matthew Reed, Jan Pohl, William Shafer, Fionnuala McAleese, Timothy Foster, Jim Travis, and Jan Potempa
Antimicrob. Agents Chemother. December 2004 48: 4673-4679;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron Carrying a Novel Metallo-ß-Lactamase Gene, bla_IMP-16, and a Fused Form of Aminoglycoside-Resistant Gene aac(6')-30/aac(6')-Ib': Report from the SENTRY Antimicrobial Surveillance Program
Rodrigo E. Mendes, Mark A. Toleman, Julival Ribeiro, Helio S. Sader, Ronald N. Jones, and Timothy R. Walsh
Antimicrob. Agents Chemother. December 2004 48: 4693-4702;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evolution of Ciprofloxacin-Resistant Staphylococcus aureus in In Vitro Pharmacokinetic Environments
Jeffrey J. Campion, Patrick J. McNamara, and Martin E. Evans
Antimicrob. Agents Chemother. December 2004 48: 4733-4744;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Derivatives of a Vancomycin-Resistant Staphylococcus aureus Strain Isolated at Hershey Medical Center
Bülent Bozdogan, Lois Ednie, Kim Credito, Klaudia Kosowska, and Peter C. Appelbaum
Antimicrob. Agents Chemother. December 2004 48: 4762-4765;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of the THIN-B Metallo-ß-Lactamase of Janthinobacterium lividum
Jean-Denis Docquier, Teresa Lopizzo, Sabrina Liberatori, Manuela Prenna, Maria Cristina Thaller, Jean-Marie Frère, and Gian Maria Rossolini
Antimicrob. Agents Chemother. December 2004 48: 4778-4783;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Outbreak of Klebsiella pneumoniae Producing a New Carbapenem- Hydrolyzing Class A ß-Lactamase, KPC-3, in a New York Medical Center
Neil Woodford, Philip M. Tierno, Jr., Katherine Young, Luke Tysall, Marie-France I. Palepou, Elaina Ward, Ronald E. Painter, Deborah F. Suber, Daniel Shungu, Lynn L. Silver, Kenneth Inglima, John Kornblum, and David M. Livermore
Antimicrob. Agents Chemother. December 2004 48: 4793-4799;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Content of Lysyl-Phosphatidylglycerol in the Cytoplasmic Membrane Affects Susceptibility to Moenomycin, as Well as Vancomycin, Gentamicin, and Antimicrobial Peptides, in Staphylococcus aureus
Hiromi Nishi, Hitoshi Komatsuzawa, Tamaki Fujiwara, Nadine McCallum, and Motoyuki Sugai
Antimicrob. Agents Chemother. December 2004 48: 4800-4807;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular and Kinetic Comparison of the Novel Extended-Spectrum ß-Lactamases CTX-M-25 and CTX-M-26
Craig J. Munday, David A. Boyd, Nigel Brenwald, Mark Miller, Jennifer M. Andrews, Richard Wise, Michael R. Mulvey, and Peter M. Hawkey
Antimicrob. Agents Chemother. December 2004 48: 4829-4834;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics in Animals and Humans of a First-in-Class Peptide Deformylase Inhibitor
Sandhya Ramanathan-Girish, Juliet McColm, John M. Clements, Phil Taupin, Sue Barrowcliffe, John Hevizi, Sharon Safrin, Clive Moore, Gary Patou, Heinz Moser, Alison Gadd, Ute Hoch, Vernon Jiang, Denene Lofland, and Kirk W. Johnson
Antimicrob. Agents Chemother. December 2004 48: 4835-4842;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

ß-Lactamase Gene Expression in a Penicillin-Resistant Bacillus anthracis Strain
Yahua Chen, Fred C. Tenover, and Theresa M. Koehler
Antimicrob. Agents Chemother. December 2004 48: 4873-4877;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

VanE-Type Vancomycin-Resistant Enterococcus faecalis Clinical Isolates from Australia
Lorena Abadía-Patiño, Keryn Christiansen, Jan Bell, Patrice Courvalin, and Bruno Périchon
Antimicrob. Agents Chemother. December 2004 48: 4882-4885;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

PCR-Restriction Fragment Length Polymorphism Assay for Detection of gyrA Mutations Associated with Fluoroquinolone Resistance in Campylobacter coli
Rodrigo Alonso, Estibaliz Mateo, Cecilia Girbau, Estibaliz Churruca, Irati Martinez, and Aurora Fernández-Astorga
Antimicrob. Agents Chemother. December 2004 48: 4886-4888;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chromosome-Encoded CTX-M-3 from Kluyvera ascorbata: a Possible Origin of Plasmid-Borne CTX-M-1-Derived Cefotaximases
María Margarita Rodríguez, Pablo Power, Marcela Radice, Carlos Vay, Angela Famiglietti, Moreno Galleni, Juan A. Ayala, and Gabriel Gutkind
Antimicrob. Agents Chemother. December 2004 48: 4895-4897;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Members of the Genera Paenibacillus and Rhodococcus Harbor Genes Homologous to Enterococcal Glycopeptide Resistance Genes vanA and vanB
L. Guardabassi, H. Christensen, H. Hasman, and A. Dalsgaard
Antimicrob. Agents Chemother. December 2004 48: 4915-4918;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Intranasal Interleukin-12 Treatment Promotes Antimicrobial Clearance and Survival in Pulmonary Francisella tularensis subsp. novicida Infection
Michael A. Pammit, Varija N. Budhavarapu, Erin K. Raulie, Karl E. Klose, Judy M. Teale, and Bernard P. Arulanandam
Antimicrob. Agents Chemother. December 2004 48: 4513-4519;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

PnuC and the Utilization of the Nicotinamide Riboside Analog 3-Aminopyridine in Haemophilus influenzae
Elizabeta Sauer, Melisa Merdanovic, Anne Price Mortimer, Gerhard Bringmann, and Joachim Reidl
Antimicrob. Agents Chemother. December 2004 48: 4532-4541;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid, Simple In Vivo Screen for New Drugs Active against Mycobacterium tuberculosis
Boris V. Nikonenko, Rowena Samala, Leo Einck, and Carol A. Nacy
Antimicrob. Agents Chemother. December 2004 48: 4550-4555;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

n-6 Polyunsaturated Fatty Acids Enhance the Activities of Ceftazidime and Amikacin in Experimental Sepsis Caused by Multidrug-Resistant Pseudomonas aeruginosa
Evangelos J. Giamarellos-Bourboulis, Maria Mouktaroudi, Theodoros Adamis, Vassilios Koussoulas, Fotini Baziaka, Despina Perrea, Panayotis E. Karayannacos, and Helen Giamarellou
Antimicrob. Agents Chemother. December 2004 48: 4713-4717;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Atovaquone Maintenance Therapy Prevents Reactivation of Toxoplasmic Encephalitis in a Murine Model of Reactivated Toxoplasmosis
Ildiko R. Dunay, Markus M. Heimesaat, Faris Nadiem Bushrab, Rainer H. Müller, Hartmut Stocker, Keikawus Arasteh, Michael Kurowski, Rudolf Fitzner, Klaus Borner, and Oliver Liesenfeld
Antimicrob. Agents Chemother. December 2004 48: 4848-4854;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Glucocorticoids Increase In Vitro and In Vivo Activities of Antibiotics against Chlamydophila pneumoniae
Dario Caronzolo, Valeria Lucini, Marilou Pannacci, Silvia Grosso, Federica Colleoni, Franco Fraschini, and Francesco Scaglione
Antimicrob. Agents Chemother. December 2004 48: 4878-4881;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Need for Early Antifungal Treatment Confirmed in Experimental Disseminated Candida albicans Infection
Donna M. MacCallum and Frank C. Odds
Antimicrob. Agents Chemother. December 2004 48: 4911-4914;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Synthetic N-Terminal Peptide of Human Lactoferrin, hLF(1-11), Is Highly Effective against Experimental Infection Caused by Multidrug-Resistant Acinetobacter baumannii
Lenie Dijkshoorn, Carlo P. J. M. Brouwer, Sylvia J. P. Bogaards, Alexandr Nemec, Peterhans J. van den Broek, and Peter H. Nibbering
Antimicrob. Agents Chemother. December 2004 48: 4919-4921;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

In Vitro Evaluation of the Effectiveness of the Macrolide Rokitamycin and Chlorpromazine against Acanthamoeba castellanii
A. Mattana, G. Biancu, L. Alberti, A. Accardo, G. Delogu, P. L. Fiori, and P. Cappuccinelli
Antimicrob. Agents Chemother. December 2004 48: 4520-4527;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen
Simon J. F. Macdonald, Keith G. Watson, Rachel Cameron, David K. Chalmers, Derek A. Demaine, Rob J. Fenton, David Gower, J. Nicole Hamblin, Stephanie Hamilton, Graham J. Hart, Graham G. A. Inglis, Betty Jin, Haydn T. Jones, Darryl B. McConnell, Andy M. Mason, Van Nguyen, Ian J. Owens, Nigel Parry, Phillip A. Reece, Stephen E. Shanahan, Donna Smith, Wen-Yang Wu, and Simon P. Tucker
Antimicrob. Agents Chemother. December 2004 48: 4542-4549;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Activities of Linezolid, Telithromycin, Clarithromycin, Levofloxacin, Moxifloxacin, and Four Conventional Antimycobacterial Drugs against Mycobacterium kansasii
Fernando Alcaide, Laura Calatayud, Miguel Santín, and Rogelio Martín
Antimicrob. Agents Chemother. December 2004 48: 4562-4565;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as ß-Lactamase Inhibitors
William J. Weiss, Peter J. Petersen, Timothy M. Murphy, LuAnna Tardio, Youjun Yang, Patricia A. Bradford, Aranapakam M. Venkatesan, Takao Abe, Takeshi Isoda, Ado Mihira, Hideki Ushirogochi, Tsuyoshi Takasake, Steve Projan, John O'Connell, and Tarek S. Mansour
Antimicrob. Agents Chemother. December 2004 48: 4589-4596;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

National Surveillance of Antimicrobial Resistance in Pseudomonas aeruginosa Isolates Obtained from Intensive Care Unit Patients from 1993 to 2002
Marilee D. Obritsch, Douglas N. Fish, Robert MacLaren, and Rose Jung
Antimicrob. Agents Chemother. December 2004 48: 4606-4610;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Activity of a Competence-Stimulating Peptide in Experimental Sepsis Caused by Streptococcus pneumoniae
Marco R. Oggioni, Francesco Iannelli, Susanna Ricci, Damiana Chiavolini, Riccardo Parigi, Claudia Trappetti, Jean-Pierre Claverys, and Gianni Pozzi
Antimicrob. Agents Chemother. December 2004 48: 4725-4732;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Antibiotic Susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by Real-Time PCR
S. Branger, J. M. Rolain, and D. Raoult
Antimicrob. Agents Chemother. December 2004 48: 4822-4828;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Antibiotic MICs for Helicobacter pylori Strains over a 16-Year Period in Patients from Seoul, South Korea
Jung Mogg Kim, Joo Sung Kim, Hyun Chae Jung, Nayoung Kim, Young-Jeon Kim, and In Sung Song
Antimicrob. Agents Chemother. December 2004 48: 4843-4847;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Neuraminidase Inhibitor-Rimantadine Combinations Exert Additive and Synergistic Anti-Influenza Virus Effects in MDCK Cells
Elena A. Govorkova, Hong-Bin Fang, Ming Tan, and Robert G. Webster
Antimicrob. Agents Chemother. December 2004 48: 4855-4863;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimycoplasmal Activity of Hydroxytyrosol
Pio Maria Furneri, Anna Piperno, Antonella Sajia, and Giuseppe Bisignano
Antimicrob. Agents Chemother. December 2004 48: 4892-4894;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of OPT-80 and Comparator Drugs against Intestinal Bacteria
Sydney M. Finegold, Denise Molitoris, Marja-Liisa Vaisanen, Yuli Song, Chengxu Liu, and Mauricio Bolaños
Antimicrob. Agents Chemother. December 2004 48: 4898-4902;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility of Bordetella bronchiseptica Isolates from Porcine Respiratory Tract Infections
Kristina Kadlec, Corinna Kehrenberg, Jürgen Wallmann, and Stefan Schwarz
Antimicrob. Agents Chemother. December 2004 48: 4903-4906;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients
William J. Steinbach, Nina Singh, Jackie L. Miller, Daniel K. Benjamin, Jr., Wiley A. Schell, Joseph Heitman, and John R. Perfect
Antimicrob. Agents Chemother. December 2004 48: 4922-4925;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence in Asian Countries of Staphylococcus aureus with Reduced Susceptibility to Vancomycin
Jae-Hoon Song, Keiichi Hiramatsu, Ji Yoeun Suh, Kwan Soo Ko, Teruyo Ito, Maria Kapi, Sungmin Kiem, Yeon-Sook Kim, Won Sup Oh, Kyong Ran Peck, Nam Yong Lee and the Asian Network for Surveillance of Resistant Pathogens Study Group
Antimicrob. Agents Chemother. December 2004 48: 4926-4928;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Bloodstream Infections Due to Extended-Spectrum ß-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae: Risk Factors for Mortality and Treatment Outcome, with Special Emphasis on Antimicrobial Therapy
Cheol-In Kang, Sung-Han Kim, Wan Beom Park, Ki-Deok Lee, Hong-Bin Kim, Eui-Chong Kim, Myoung-Don Oh, and Kang-Won Choe
Antimicrob. Agents Chemother. December 2004 48: 4574-4581;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amoxicillin-Clavulanate Therapy Increases Childhood Nasal Colonization by Methicillin-Susceptible Staphylococcus aureus Strains Producing High Levels of Penicillinase
Didier Guillemot, Stephane Bonacorsi, John S. Blanchard, Philippe Weber, Sylvie Simon, Bruno Guesnon, Edouard Bingen, and Claude Carbon
Antimicrob. Agents Chemother. December 2004 48: 4618-4623;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of High-Inoculum Staphylococcus aureus on the Activities of Nafcillin, Vancomycin, Linezolid, and Daptomycin, Alone and in Combination with Gentamicin, in an In Vitro Pharmacodynamic Model
Kerry L. LaPlante and Michael J. Rybak
Antimicrob. Agents Chemother. December 2004 48: 4665-4672;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Profiling of Piperacillin in the Presence of Tazobactam in Patients through the Use of Population Pharmacokinetic Models and Monte Carlo Simulation
Thomas P. Lodise, Jr., Ben Lomaestro, Keith A. Rodvold, Larry H. Danziger, and George L. Drusano
Antimicrob. Agents Chemother. December 2004 48: 4718-4724;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antistaphylococcal Activity of WCK 771, a Tricyclic Fluoroquinolone, in Animal Infection Models
Mahesh V. Patel, Noel J. De Souza, Shrikant V. Gupte, Mohammad A. Jafri, Sachin S. Bhagwat, Yati Chugh, Habil F. Khorakiwala, Michael R. Jacobs, and Peter C. Appelbaum
Antimicrob. Agents Chemother. December 2004 48: 4754-4761;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Liposomal Nystatin in Patients with Invasive Aspergillosis Refractory to or Intolerant of Amphotericin B
Fritz Offner, Vladimir Krcmery, Marc Boogaerts, Chantal Doyen, Dan Engelhard, Patricia Ribaud, Catherine Cordonnier, Ben de Pauw, Simon Durrant, Jean-Pierre Marie, Philippe Moreau, Harry Guiot, George Samonis, Richard Sylvester, Raoul Herbrecht the EORTC Invasive Fungal Infections Group
Antimicrob. Agents Chemother. December 2004 48: 4808-4812;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Effect of Sucralfate on Antibiotic Therapy for Helicobacter pylori Infection in Mice
Koichiro Watanabe, Kazunari Murakami, Ryugo Sato, Koji Kashimura, Masahiro Miura, Satoshi Ootsu, Hajime Miyajima, Masaru Nasu, Tadayoshi Okimoto, Masaaki Kodama, and Toshio Fujioka
Antimicrob. Agents Chemother. December 2004 48: 4582-4588;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Pharmacodynamics of Intravenous Levofloxacin at 750 Milligrams and Various Doses of Metronidazole in Healthy Adult Subjects
Kelly A. Sprandel, Christopher A. Schriever, Susan L. Pendland, John P. Quinn, Mark H. Gotfried, Suzanne Hackett, Mary Beth Graham, Larry H. Danziger, and Keith A. Rodvold
Antimicrob. Agents Chemother. December 2004 48: 4597-4605;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Telithromycin in Plasma and Soft Tissues after Single-Dose Administration to Healthy Volunteers
Rainer Gattringer, Eleonora Urbauer, Friederike Traunmüller, Markus Zeitlinger, Pejman Dehghanyar, Petra Zeleny, Wolfgang Graninger, Markus Müller, and Christian Joukhadar
Antimicrob. Agents Chemother. December 2004 48: 4650-4653;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics and Pharmacodynamics of Garenoxacin in Patients with Community-Acquired Respiratory Tract Infections
Scott Van Wart, Luann Phillips, Elizabeth A. Ludwig, Rene Russo, Diptee A. Gajjar, Akintunde Bello, Paul G. Ambrose, Christopher Costanzo, Thaddeus H. Grasela, Roger Echols, and Dennis M. Grasela
Antimicrob. Agents Chemother. December 2004 48: 4766-4777;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Gln145Met/Leu Changes in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nucleoside and Nonnucleoside Analogs and Impair Virus Replication
Stefania Paolucci, Fausto Baldanti, Giovanni Maga, Reynel Cancio, Maurizio Zazzi, Maurizio Zavattoni, Antonella Chiesa, Silvio Spadari, and Giuseppe Gerna
Antimicrob. Agents Chemother. December 2004 48: 4611-4617;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Effects of Ribavirin following Intraventricular Administration for Treatment of Subacute Sclerosing Panencephalitis
Mitsuaki Hosoya, Shuichi Mori, Akemi Tomoda, Kenji Mori, Yukio Sawaishi, Hiroshi Kimura, Shiro Shigeta, and Hitoshi Suzuki
Antimicrob. Agents Chemother. December 2004 48: 4631-4635;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Metabolism of the Anti-Hepatitis C Virus Nucleoside ß-D-N⁴-Hydroxycytidine in Different Liver Cells
Brenda I. Hernandez-Santiago, Thierry Beltran, Lieven Stuyver, Chung K. Chu, and Raymond F. Schinazi
Antimicrob. Agents Chemother. December 2004 48: 4636-4642;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1
Koen Andries, Hilde Azijn, Theo Thielemans, Donald Ludovici, Michael Kukla, Jan Heeres, Paul Janssen, Bart De Corte, Johan Vingerhoets, Rudi Pauwels, and Marie-Pierre de Béthune
Antimicrob. Agents Chemother. December 2004 48: 4680-4686;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinically Relevant Interpretation of Genotype and Relationship to Plasma Drug Concentrations for Resistance to Saquinavir-Ritonavir in Human Immunodeficiency Virus Type 1 Protease Inhibitor-Experienced Patients
Anne-Geneviève Marcelin, Cécile Dalban, Gilles Peytavin, Claire Lamotte, Rachid Agher, Constance Delaugerre, Marc Wirden, Françoise Conan, Sylvie Dantin, Christine Katlama, Dominique Costagliola, and Vincent Calvez
Antimicrob. Agents Chemother. December 2004 48: 4687-4692;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections
Earl R. Kern, Deborah J. Bidanset, Caroll B. Hartline, Zhaohua Yan, Jiri Zemlicka, and Debra C. Quenelle
Antimicrob. Agents Chemother. December 2004 48: 4745-4753;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination of a Hepatitis C Virus NS3-NS4A Protease Inhibitor and Alpha Interferon Synergistically Inhibits Viral RNA Replication and Facilitates Viral RNA Clearance in Replicon Cells
Kai Lin, Ann D. Kwong, and Chao Lin
Antimicrob. Agents Chemother. December 2004 48: 4784-4792;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase
Anita Y. M. Howe, Johnathan Bloom, Carl J. Baldick, Christopher A. Benetatos, Huiming Cheng, Joel S. Christensen, Srinivas K. Chunduru, Glen A. Coburn, Boris Feld, Ariamala Gopalsamy, William P. Gorczyca, Steve Herrmann, Stephen Johann, Xiaoqun Jiang, Michelle L. Kimberland, Girija Krisnamurthy, Matthew Olson, Mark Orlowski, Steve Swanberg, Ian Thompson, Megan Thorn, Alfred Del Vecchio, Dorothy C. Young, Marja van Zeijl, John W. Ellingboe, Janis Upeslacis, Marc Collett, Tarek S. Mansour, and John F. O'Connell
Antimicrob. Agents Chemother. December 2004 48: 4813-4821;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance
Elizabeth Johnston, Mark A. Winters, Soo-Yon Rhee, Thomas C. Merigan, Celia A. Schiffer, and Robert W. Shafer
Antimicrob. Agents Chemother. December 2004 48: 4864-4868;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

A Radio Frequency Electric Current Enhances Antibiotic Efficacy against Bacterial Biofilms
R. Caubet, F. Pedarros-Caubet, M. Chu, E. Freye, M. de Belém Rodrigues, J. M. Moreau, and W. J. Ellison
Antimicrob. Agents Chemother. December 2004 48: 4662-4664;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative
Julie Millet, Sandrine Alibert, Marylin Torrentino-Madamet, Christophe Rogier, Christiane Santelli-Rouvier, Patricia Bigot, Joel Mosnier, Eric Baret, Jacques Barbe, Daniel Parzy, and Bruno Pradines
Antimicrob. Agents Chemother. December 2004 48: 4869-4872;
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Effects of a Number of Classes of 50S Inhibitors on Stop Codon Readthrough during Protein Synthesis
Jill Thompson, Catherine A. Pratt, and Albert E. Dahlberg
Antimicrob. Agents Chemother. December 2004 48: 4889-4891;
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A Subinhibitory Concentration of Clarithromycin Inhibits Mycobacterium avium Biofilm Formation
George Carter, Lowell S. Young, and Luiz E. Bermudez
Antimicrob. Agents Chemother. December 2004 48: 4907-4910;
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Chemistry; Biosynthesis:

Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae
Shannon L. Ward, Zhihao Hu, Andreas Schirmer, Ralph Reid, W. Peter Revill, Christopher D. Reeves, Oleg V. Petrakovsky, Steven D. Dong, and Leonard Katz
Antimicrob. Agents Chemother. December 2004 48: 4703-4712;
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Letters:

First Detection of a Carbapenem-Hydrolyzing Metalloenzyme in an Enterobacteriaceae Isolate in France
Marie-Frédérique Lartigue, Laurent Poirel, and Patrice Nordmann
Antimicrob. Agents Chemother. December 2004 48: 4929-4930;
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Errata:

Efficacy of Posaconazole in a Murine Model of Central Nervous System Aspergillosis
Jackie K. Imai, Gaurav Singh, Karl V. Clemons, and David A. Stevens
Antimicrob. Agents Chemother. December 2004 48: 4931
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