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Minireviews:

Markus Mueller, Amparo de la Peña, and Hartmut Derendorf

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Kill Curves versus MIC
Antimicrob. Agents Chemother. 2004 48: 369-377. [Full Text] [PDF]  

Experimental Therapeutics:

Shuichi Miyazaki, Kenichi Okazaki, Masakatsu Tsuji, and Keizo Yamaguchi

Pharmacodynamics of S-3578, a Novel Cephem, in Murine Lung and Systemic Infection Models
Antimicrob. Agents Chemother. 2004 48: 378-383. [Abstract] [Full Text] [PDF]  

J. L. Miller, W. A. Schell, E. A. Wills, D. L. Toffaletti, M. Boyce, D. K. Benjamin, Jr., J. Bartroli, and J. R. Perfect

In Vitro and In Vivo Efficacies of the New Triazole Albaconazole against Cryptococcus neoformans
Antimicrob. Agents Chemother. 2004 48: 384-387. [Abstract] [Full Text] [PDF]  

F. Odds, J. Ausma, F. Van Gerven, F. Woestenborghs, L. Meerpoel, J. Heeres, H. Vanden Bossche, and M. Borgers

In Vitro and In Vivo Activities of the Novel Azole Antifungal Agent R126638
Antimicrob. Agents Chemother. 2004 48: 388-391. [Abstract] [Full Text] [PDF]  

J. Alberola, A. Rodríguez, O. Francino, X. Roura, L. Rivas, and D. Andreu

Safety and Efficacy of Antimicrobial Peptides against Naturally Acquired Leishmaniasis
Antimicrob. Agents Chemother. 2004 48: 641-643. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

Carlos Bantar, Eduardo Vesco, Claudia Heft, Francisco Salamone, Marcelo Krayeski, Hernán Gomez, María Alicia Coassolo, Alejandro Fiorillo, Diego Franco, Carina Arango, Fernando Duret, and María Eugenia Oliva

Replacement of Broad-Spectrum Cephalosporins by Piperacillin-Tazobactam: Impact on Sustained High Rates of Bacterial Resistance
Antimicrob. Agents Chemother. 2004 48: 392-395. [Abstract] [Full Text] [PDF]  

Biologic Response Modifiers:

Lloyd W. Turtinen, David N. Prall, Lindsay A. Bremer, Rachel E. Nauss, and Scott C. Hartsel

Antibody Array-Generated Profiles of Cytokine Release from THP-1 Leukemic Monocytes Exposed to Different Amphotericin B Formulations
Antimicrob. Agents Chemother. 2004 48: 396-403. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Debra C. Quenelle, Deborah J. Collins, W. Brad Wan, James R. Beadle, Karl Y. Hostetler, and Earl R. Kern

Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir
Antimicrob. Agents Chemother. 2004 48: 404-412. [Abstract] [Full Text] [PDF]  

Christopher Cianci, Kuo-Long Yu, Keith Combrink, Ny Sin, Bradley Pearce, Alan Wang, Rita Civiello, Stacey Voss, Guangxiang Luo, Kathy Kadow, Eugene V. Genovesi, Brian Venables, Hatice Gulgeze, Ashok Trehan, Jennifer James, Lucinda Lamb, Ivette Medina, Julia Roach, Zheng Yang, Lisa Zadjura, Richard Colonno, Junius Clark, Nicholas Meanwell, and Mark Krystal

Orally Active Fusion Inhibitor of Respiratory Syncytial Virus
Antimicrob. Agents Chemother. 2004 48: 413-422. [Abstract] [Full Text] [PDF]  

Jeffrey M. Jacobson, Robert J. Israel, Israel Lowy, Nancy A. Ostrow, Linda S. Vassilatos, Melanie Barish, Diep N. H. Tran, Brian M. Sullivan, Thomas J. Ketas, Tobias J. O'Neill, Kirsten A. Nagashima, Wei Huang, Christos J. Petropoulos, John P. Moore, Paul J. Maddon, and William C. Olson

Treatment of Advanced Human Immunodeficiency Virus Type 1 Disease with the Viral Entry Inhibitor PRO 542
Antimicrob. Agents Chemother. 2004 48: 423-429. [Abstract] [Full Text] [PDF]  

Edward P. Acosta, Arlene Bardeguez, Carmen D. Zorrilla, Russell Van Dyke, Michael D. Hughes, Sharon Huang, Lisa Pompeo, Alice M. Stek, Jane Pitt, D. Heather Watts, Elizabeth Smith, Eleanor Jiménez, Lynne Mofenson, and the Pediatric AIDS Clinical Trials Group 386 Protocol Team,

Pharmacokinetics of Saquinavir plus Low-Dose Ritonavir in Human Immunodeficiency Virus-Infected Pregnant Women
Antimicrob. Agents Chemother. 2004 48: 430-436. [Abstract] [Full Text] [PDF]  

N. T. Parkin, N. S. Hellmann, J. M. Whitcomb, L. Kiss, C. Chappey, and C. J. Petropoulos

Natural Variation of Drug Susceptibility in Wild-Type Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2004 48: 437-443. [Abstract] [Full Text] [PDF]  

Lay Myint, Masakazu Matsuda, Zene Matsuda, Yoshiyuki Yokomaku, Tomoko Chiba, Aiko Okano, Kaneo Yamada, and Wataru Sugiura

Gag Non-Cleavage Site Mutations Contribute to Full Recovery of Viral Fitness in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2004 48: 444-452. [Abstract] [Full Text] [PDF]  

David Durantel, Sandra Carrouée-Durantel, Norica Branza-Nichita, Raymond A. Dwek, and Nicole Zitzmann

Effects of Interferon, Ribavirin, and Iminosugar Derivatives on Cells Persistently Infected with Noncytopathic Bovine Viral Diarrhea Virus
Antimicrob. Agents Chemother. 2004 48: 497-504. [Abstract] [Full Text] [PDF]  

Hervé Trout, France Mentré, Xavière Panhard, Alissi Kodjo, Lélia Escaut, Pascal Pernet, Jean-Gérard Gobert, Daniel Vittecoq, Anne-Laure Knellwolf, Charles Caulin, and Jean-François Bergmann

Enhanced Saquinavir Exposure in Human Immunodeficiency Virus Type 1-Infected Patients with Diarrhea and/or Wasting Syndrome
Antimicrob. Agents Chemother. 2004 48: 538-545. [Abstract] [Full Text] [PDF]  

Cecile Le Saint, Raphael Terreux, Daniele Duval, Jacques Durant, Helene Ettesse, Pierre Dellamonica, Roger Guedj, Jean Pierre Vincent, and Anny Cupo

Determination of ddATP Levels in Human Immunodeficiency Virus-Infected Patients Treated with Dideoxyinosine
Antimicrob. Agents Chemother. 2004 48: 589-595. [Abstract] [Full Text] [PDF]  

Odile Launay, Michel Tod, Kamel Louchahi, Linda Belarbi, Olivier Bouchaud, Nathalie Mémain, Olivier Petitjean, Michel Robineau, Loïc Guillevin, and Olivier Lortholary

Differential Diffusions of Indinavir and Lopinavir in Genital Secretions of Human Immunodeficiency Virus-Infected Women
Antimicrob. Agents Chemother. 2004 48: 632-634. [Abstract] [Full Text] [PDF]  

Marc Wirden, Constance Delaugerre, Anne Genevieve Marcelin, Nadine Ktorza, Hocine Ait Mohand, Stephanie Dominguez, Luminita Schneider, Jade Ghosn, Michele Pauchard, Dominique Costagliola, Christine Katlama, and Vincent Calvez

Comparison of the Dynamics of Resistance-Associated Mutations to Nucleoside Reverse Transcriptase Inhibitors, Nonnucleoside Reverse Transcriptase Inhibitors, and Protease Inhibitors after Cessation of Antiretroviral Combination Therapy
Antimicrob. Agents Chemother. 2004 48: 644-647. [Abstract] [Full Text] [PDF]  

Lieven J. Stuyver, Tamara R. McBrayer, Tony Whitaker, Phillip M. Tharnish, Mangala Ramesh, Stefania Lostia, Leanne Cartee, Junxing Shi, Ann Hobbs, Raymond F. Schinazi, Kyoichi A. Watanabe, and Michael J. Otto

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2'-Deoxy-2'-Fluorocytidine
Antimicrob. Agents Chemother. 2004 48: 651-654. [Abstract] [Full Text] [PDF]  

Li Huang, Xiong Yuan, Christopher Aiken, and Chin Ho Chen

Bifunctional Anti-Human Immunodeficiency Virus Type 1 Small Molecules with Two Novel Mechanisms of Action
Antimicrob. Agents Chemother. 2004 48: 663-665. [Abstract] [Full Text] [PDF]  

Mechanisms of Resistance:

Yuki Katayama, Hong-Zhong Zhang, and Henry F. Chambers

PBP 2a Mutations Producing Very-High-Level Resistance to Beta-Lactams
Antimicrob. Agents Chemother. 2004 48: 453-459. [Abstract] [Full Text] [PDF]  

S. Pereyre, C. Guyot, H. Renaudin, A. Charron, C. Bébéar, and C. M. Bébéar

In Vitro Selection and Characterization of Resistance to Macrolides and Related Antibiotics in Mycoplasma pneumoniae
Antimicrob. Agents Chemother. 2004 48: 460-465. [Abstract] [Full Text] [PDF]  

Florian Marks, Christian G. Meyer, Jürgen Sievertsen, Christian Timmann, Jennifer Evans, Rolf D. Horstmann, and Jürgen May

Genotyping of Plasmodium falciparum Pyrimethamine Resistance by Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry
Antimicrob. Agents Chemother. 2004 48: 466-472. [Abstract] [Full Text] [PDF]  

Michael Green, Judith M. Martin, Karen A. Barbadora, Bernard Beall, and Ellen R. Wald

Reemergence of Macrolide Resistance in Pharyngeal Isolates of Group A Streptococci in Southwestern Pennsylvania
Antimicrob. Agents Chemother. 2004 48: 473-476. [Abstract] [Full Text] [PDF]  

Maria-Luigi Colombo, Sophie Hanique, Stéphane L. Baurin, Cédric Bauvois, Kris De Vriendt, Jozef J. Van Beeumen, Jean-Marie Frère, and Bernard Joris

The ybxI Gene of Bacillus subtilis 168 Encodes a Class D ß-Lactamase of Low Activity
Antimicrob. Agents Chemother. 2004 48: 484-490. [Abstract] [Full Text] [PDF]  

Yohei Doi, Keiko Yokoyama, Kunikazu Yamane, Jun-ichi Wachino, Naohiro Shibata, Tetsuya Yagi, Keigo Shibayama, Haru Kato, and Yoshichika Arakawa

Plasmid-Mediated 16S rRNA Methylase in Serratia marcescens Conferring High-Level Resistance to Aminoglycosides
Antimicrob. Agents Chemother. 2004 48: 491-496. [Abstract] [Full Text] [PDF]  

M. Alvarez, J. H. Tran, N. Chow, and G. A. Jacoby

Epidemiology of Conjugative Plasmid-Mediated AmpC ß-Lactamases in the United States
Antimicrob. Agents Chemother. 2004 48: 533-537. [Abstract] [Full Text] [PDF]  

Stein Christian Mohn, Arve Ulvik, Roland Jureen, Rob J. L. Willems, Janetta Top, Helen Leavis, Stig Harthug, and Nina Langeland

Duplex Real-Time PCR Assay for Rapid Detection of Ampicillin-Resistant Enterococcus faecium
Antimicrob. Agents Chemother. 2004 48: 556-560. [Abstract] [Full Text] [PDF]  

Augustine F. B. Cheng, Wing W. Yew, Edward W. C. Chan, Miu L. Chin, Mamie M. M. Hui, and Raphael C. Y. Chan

Multiplex PCR Amplimer Conformation Analysis for Rapid Detection of gyrA Mutations in Fluoroquinolone-Resistant Mycobacterium tuberculosis Clinical Isolates
Antimicrob. Agents Chemother. 2004 48: 596-601. [Abstract] [Full Text] [PDF]  

Heidi Segal, E. C. Nelson, and B. Gay Elisha

Genetic Environment and Transcription of ampC in an Acinetobacter baumannii Clinical Isolate
Antimicrob. Agents Chemother. 2004 48: 612-614. [Abstract] [Full Text] [PDF]  

Corinna Kehrenberg and Stefan Schwarz

fexA, a Novel Staphylococcus lentus Gene Encoding Resistance to Florfenicol and Chloramphenicol
Antimicrob. Agents Chemother. 2004 48: 615-618. [Abstract] [Full Text] [PDF]  

E. Limburg, R. Gahlmann, H.-P. Kroll, and D. Beyer

Ribosomal Alterations Contribute to Bacterial Resistance against the Dipeptide Antibiotic TAN 1057
Antimicrob. Agents Chemother. 2004 48: 619-622. [Abstract] [Full Text] [PDF]  

Arunachalam Muthaiyan, Radheshyam K. Jayaswal, and Brian J. Wilkinson

Intact mutS in Laboratory-Derived and Clinical Glycopeptide-Intermediate Staphylococcus aureus Strains
Antimicrob. Agents Chemother. 2004 48: 623-625. [Abstract] [Full Text] [PDF]  

Jun Yatsuyanagi, Shioko Saito, Seizaburo Harata, Noriyuki Suzuki, Yuko Ito, Ken-ichi Amano, and Katsuhiko Enomoto

Class 1 Integron Containing Metallo-ß-Lactamase Gene bla_VIM-2 in Pseudomonas aeruginosa Clinical Strains Isolated in Japan
Antimicrob. Agents Chemother. 2004 48: 626-628. [Abstract] [Full Text] [PDF]  

Maria Virginia Villegas, Adriana Correa, Federico Perez, Tania Zuluaga, Marcela Radice, Gabriel Gutkind, José María Casellas, Juan Ayala, Karen Lolans, John P. Quinn, and the Colombian Nosocomial Resistance Study Group,

CTX-M-12 ß-Lactamase in a Klebsiella pneumoniae Clinical Isolate in Colombia
Antimicrob. Agents Chemother. 2004 48: 629-631. [Abstract] [Full Text] [PDF]  

Francesco Luzzaro, Jean-Denis Docquier, Céline Colinon, Andrea Endimiani, Gianluigi Lombardi, Gianfranco Amicosante, Gian Maria Rossolini, and Antonio Toniolo

Emergence in Klebsiella pneumoniae and Enterobacter cloacae Clinical Isolates of the VIM-4 Metallo-ß-Lactamase Encoded by a Conjugative Plasmid
Antimicrob. Agents Chemother. 2004 48: 648-650. [Abstract] [Full Text] [PDF]  

Raquel Barbolla, Mariana Catalano, Betina E. Orman, Angela Famiglietti, Carlos Vay, Jorgelina Smayevsky, Daniela Centrón, and Silvia A. Piñeiro

Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates
Antimicrob. Agents Chemother. 2004 48: 666-669. [Abstract] [Full Text] [PDF]  

Gururaja Perumal Pazhani, Bhaswati Sarkar, Thandavarayan Ramamurthy, S. K. Bhattacharya, Yoshifumi Takeda, and S. K. Niyogi

Clonal Multidrug-Resistant Shigella dysenteriae Type 1 Strains Associated with Epidemic and Sporadic Dysenteries in Eastern India
Antimicrob. Agents Chemother. 2004 48: 681-684. [Abstract] [Full Text] [PDF]  

Mechanisms of Action:

Geoffrey W. Stone, Qin Zhang, Rosario Castillo, V. Ramana Doppalapudi, Analia R. Bueno, Jean Y. Lee, Qing Li, Maria Sergeeva, Gody Khambatta, and Nafsika H. Georgopapadakou

Mechanism of Action of NB2001 and NB2030, Novel Antibacterial Agents Activated by ß-Lactamases
Antimicrob. Agents Chemother. 2004 48: 477-483. [Abstract] [Full Text] [PDF]  

Dieter Beyer, Hein-Peter Kroll, Rainer Endermann, Guido Schiffer, Stephan Siegel, Marcus Bauser, Jens Pohlmann, Michael Brands, Karl Ziegelbauer, Dieter Haebich, Christine Eymann, and Heike Brötz-Oesterhelt

New Class of Bacterial Phenylalanyl-tRNA Synthetase Inhibitors with High Potency and Broad-Spectrum Activity
Antimicrob. Agents Chemother. 2004 48: 525-532. [Abstract] [Full Text] [PDF]  

Katussevani Bernardo, Norbert Pakulat, Silke Fleer, Annabelle Schnaith, Olaf Utermöhlen, Oleg Krut, Stefan Müller, and Martin Krönke

Subinhibitory Concentrations of Linezolid Reduce Staphylococcus aureus Virulence Factor Expression
Antimicrob. Agents Chemother. 2004 48: 546-555. [Abstract] [Full Text] [PDF]  

Tanja Woyke, Michael E. Berens, Dominique B. Hoelzinger, George R. Pettit, Günther Winkelmann, and Robin K. Pettit

Differential Gene Expression in Auristatin PHE-Treated Cryptococcus neoformans
Antimicrob. Agents Chemother. 2004 48: 561-567. [Abstract] [Full Text] [PDF]  

Li Xiao, Vincent Madison, Andrew S. Chau, David Loebenberg, Robert E. Palermo, and Paul M. McNicholas

Three-Dimensional Models of Wild-Type and Mutated Forms of Cytochrome P450 14-Sterol Demethylases from Aspergillus fumigatus and Candida albicans Provide Insights into Posaconazole Binding
Antimicrob. Agents Chemother. 2004 48: 568-574. [Abstract] [Full Text] [PDF]  

Emily S. Pfeiffer and Hiroshi Hiasa

Replacement of ParC 4 Helix with That of GyrA Increases the Stability and Cytotoxicity of Topoisomerase IV-Quinolone-DNA Ternary Complexes
Antimicrob. Agents Chemother. 2004 48: 608-611. [Abstract] [Full Text] [PDF]  

Alemu Fite, Rolf Dykhuizen, Audrey Litterick, Michael Golden, and Carlo Leifert

Effects of Ascorbic Acid, Glutathione, Thiocyanate, and Iodide on Antimicrobial Activity of Acidified Nitrite
Antimicrob. Agents Chemother. 2004 48: 655-658. [Abstract] [Full Text] [PDF]  

Rachel C. Anderson, Robert E. W. Hancock, and Pak-Lam Yu

Antimicrobial Activity and Bacterial-Membrane Interaction of Ovine-Derived Cathelicidins
Antimicrob. Agents Chemother. 2004 48: 673-676. [Abstract] [Full Text] [PDF]  

Chemistry; Biosynthesis:

Anne-Marie Pons, François Delalande, Mariela Duarte, Stéphanie Benoit, Isabelle Lanneluc, Sophie Sablé, Alain Van Dorsselaer, and Gilles Cottenceau

Genetic Analysis and Complete Primary Structure of Microcin L
Antimicrob. Agents Chemother. 2004 48: 505-513. [Abstract] [Full Text] [PDF]  

Susan E. Jensen, Annie Wong, Alison Griffin, and Barry Barton

Streptomyces clavuligerus Has a Second Copy of the Proclavaminate Amidinohydrolase Gene
Antimicrob. Agents Chemother. 2004 48: 514-520. [Abstract] [Full Text] [PDF]  

Xiuhua Pang, Bertrand Aigle, Jean-Michel Girardet, Sophie Mangenot, Jean-Luc Pernodet, Bernard Decaris, and Pierre Leblond

Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome
Antimicrob. Agents Chemother. 2004 48: 575-588. [Abstract] [Full Text] [PDF]  

Pharmacology:

D. G. Musson, A. Majumdar, S. Holland, K. Birk, L. Xi, G. Mistry, D. Sciberras, J. Muckow, P. Deutsch, and J. D. Rogers

Pharmacokinetics of Total and Unbound Ertapenem in Healthy Elderly Subjects
Antimicrob. Agents Chemother. 2004 48: 521-524. [Abstract] [Full Text] [PDF]  

M. Kelli Jordan, Aaron H. Burstein, Diane Rock-Kress, Raul M. Alfaro, Alice K. Pau, Joseph A. Kovacs, and Stephen C. Piscitelli

Plasma Pharmacokinetics of Sulfadiazine Administered Twice Daily versus Four Times Daily Are Similar in Human Immunodeficiency Virus-Infected Patients
Antimicrob. Agents Chemother. 2004 48: 635-637. [Abstract] [Full Text] [PDF]  

Marc Leone, Jacques Albanèse, Emmanuelle Sampol-Manos, Nicolas Simon, Bruno Lacarelle, Bernard Bruguerolle, and Claude Martin

Moxifloxacin Penetration in Bronchial Secretions of Mechanically Ventilated Patients with Pneumonia
Antimicrob. Agents Chemother. 2004 48: 638-640. [Abstract] [Full Text] [PDF]  

Soo K. Bae, Won-Suk Chung, Eun J. Kim, Jae K. Rhee, Jong W. Kwon, Won B. Kim, and Myung G. Lee

Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect
Antimicrob. Agents Chemother. 2004 48: 659-662. [Abstract] [Full Text] [PDF]  

E. García Vázquez, J. Mensa, Y. López, P. Díaz Couchard, D. Soy, J. R. Fontenla, M. Sarasa, X. Carné, and E. Montull

Penetration of Linezolid into the Anterior Chamber (Aqueous Humor) of the Human Eye after Intravenous Administration
Antimicrob. Agents Chemother. 2004 48: 670-672. [Abstract] [Full Text] [PDF]  

Susceptibility:

Lucio Vera-Cabrera, Eva Gonzalez, Sung H. Choi, and Oliverio Welsh

In Vitro Activities of New Antimicrobials against Nocardia brasiliensis
Antimicrob. Agents Chemother. 2004 48: 602-604. [Abstract] [Full Text] [PDF]  

James H. Jorgensen, Sharon A. Crawford, M. Leticia McElmeel, and Cynthia G. Whitney

Activities of Cethromycin and Telithromycin against Recent North American Isolates of Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2004 48: 605-607. [Abstract] [Full Text] [PDF]  

Edouard Bingen, Catherine Doit, Philippe Bidet, Naima Brahimi, and Dominique Deforche

Telithromycin Susceptibility and Genomic Diversity of Macrolide-Resistant Serotype III Group B Streptococci Isolated in Perinatal Infections
Antimicrob. Agents Chemother. 2004 48: 677-680. [Abstract] [Full Text] [PDF]  

Nikolinka Antcheva, Michele Boniotto, Igor Zelezetsky, Sabrina Pacor, Maria Vittoria Verga Falzacappa, Sergio Crovella, and Alessandro Tossi

Effects of Positively Selected Sequence Variations in Human and Macaca fascicularis ß-Defensins 2 on Antimicrobial Activity
Antimicrob. Agents Chemother. 2004 48: 685-688. [Abstract] [Full Text] [PDF]  

Letters:

Michael R. Mulvey, David Boyd, Lai-King Ng, Shirley Brown, Marina Lombos, Bruce Ciebin, Aimin Li, Frances Jamieson, and Philip Stuart

First Canadian Salmonella enterica Serovar Typhi Isolate Harboring an Integron
Antimicrob. Agents Chemother. 2004 48: 689-690. [Full Text] [PDF]  

Author's Correction:

Jonathan Z. Li, Elizabeth C. Mack, and Jay A. Levy

Virucidal Efficacy of Soap and Water against Human Immunodeficiency Virus in Genital Secretions
Antimicrob. Agents Chemother. 2004 48: 691. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.