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Minireviews:

Melissa D. Johnson, Conan MacDougall, Luis Ostrosky-Zeichner, John R. Perfect, and John H. Rex

Combination Antifungal Therapy
Antimicrob. Agents Chemother. 2004 48: 693-715. [Full Text] [PDF]  

Mechanisms of Resistance:

Hedi Mammeri, Laurent Poirel, Pascal Bemer, Henri Drugeon, and Patrice Nordmann

Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC ß-Lactamase of a Serratia marcescens Clinical Isolate
Antimicrob. Agents Chemother. 2004 48: 716-720. [Abstract] [Full Text] [PDF]  

B. Helen Jost, Hien T. Trinh, J. Glenn Songer, and Stephen J. Billington

A Second Tylosin Resistance Determinant, Erm B, in Arcanobacterium pyogenes
Antimicrob. Agents Chemother. 2004 48: 721-727. [Abstract] [Full Text] [PDF]  

Robert S. Barlow, John M. Pemberton, Patricia M. Desmarchelier, and Kari S. Gobius

Isolation and Characterization of Integron-Containing Bacteria without Antibiotic Selection
Antimicrob. Agents Chemother. 2004 48: 838-842. [Abstract] [Full Text] [PDF]  

Julio Ramos-Aires, Patrick Plésiat, Lasta Kocjancic-Curty, and Thilo Köhler

Selection of an Antibiotic-Hypersusceptible Mutant of Pseudomonas aeruginosa: Identification of the GlmR Transcriptional Regulator
Antimicrob. Agents Chemother. 2004 48: 843-851. [Abstract] [Full Text] [PDF]  

Anwar Ahmed, Deepak Bararia, Sumiti Vinayak, Mohammed Yameen, Sukla Biswas, Vas Dev, Ashwani Kumar, Musharraf A. Ansari, and Yagya D. Sharma

Plasmodium falciparum Isolates in India Exhibit a Progressive Increase in Mutations Associated with Sulfadoxine-Pyrimethamine Resistance
Antimicrob. Agents Chemother. 2004 48: 879-889. [Abstract] [Full Text] [PDF]  

Cristina Pezzella, Antonia Ricci, Elisabetta DiGiannatale, Ida Luzzi, and Alessandra Carattoli

Tetracycline and Streptomycin Resistance Genes, Transposons, and Plasmids in Salmonella enterica Isolates from Animals in Italy
Antimicrob. Agents Chemother. 2004 48: 903-908. [Abstract] [Full Text] [PDF]  

Jianzhong Huang, Paul W. O'Toole, Wei Shen, Heather Amrine-Madsen, Xinhe Jiang, Neethan Lobo, Leslie M. Palmer, LeRoy Voelker, Frank Fan, Michael N. Gwynn, and Damien McDevitt

Novel Chromosomally Encoded Multidrug Efflux Transporter MdeA in Staphylococcus aureus
Antimicrob. Agents Chemother. 2004 48: 909-917. [Abstract] [Full Text] [PDF]  

B. Helen Jost, Hien T. Trinh, J. Glenn Songer, and Stephen J. Billington

Ribosomal Mutations in Arcanobacterium pyogenes Confer a Unique Spectrum of Macrolide Resistance
Antimicrob. Agents Chemother. 2004 48: 1021-1023. [Abstract] [Full Text] [PDF]  

Isabelle Verdier, Marie-Elisabeth Reverdy, Jerome Etienne, Gérard Lina, Michèle Bes, and François Vandenesch

Staphylococcus aureus Isolates with Reduced Susceptibility to Glycopeptides Belong to Accessory Gene Regulator Group I or II
Antimicrob. Agents Chemother. 2004 48: 1024-1027. [Abstract] [Full Text] [PDF]  

Sally A. Turner, Shelley N. Luck, Harry Sakellaris, Kumar Rajakumar, and Ben Adler

Role of attP in Integrase-Mediated Integration of the Shigella Resistance Locus Pathogenicity Island of Shigella flexneri
Antimicrob. Agents Chemother. 2004 48: 1028-1031. [Abstract] [Full Text] [PDF]  

Barry G. Hall

In Vitro Evolution Predicts that the IMP-1 Metallo-ß-Lactamase Does Not Have the Potential To Evolve Increased Activity against Imipenem
Antimicrob. Agents Chemother. 2004 48: 1032-1033. [Abstract] [Full Text] [PDF]  

G. Barnaud, Y. Benzerara, J. Gravisse, L. Raskine, M. J. Sanson-Le Pors, R. Labia, and G. Arlet

Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical Isolate
Antimicrob. Agents Chemother. 2004 48: 1040-1042. [Abstract] [Full Text] [PDF]  

Mechanisms of Action:

Alexey Ruzin, Guy Singh, Anatoly Severin, Youjun Yang, Russell G. Dushin, Alan G. Sutherland, Albert Minnick, Michael Greenstein, Michael K. May, David M. Shlaes, and Patricia A. Bradford

Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria
Antimicrob. Agents Chemother. 2004 48: 728-738. [Abstract] [Full Text] [PDF]  

Caroline Paris, Philippe M. Loiseau, Christian Bories, and Jaqueline Bréard

Miltefosine Induces Apoptosis-Like Death in Leishmania donovani Promastigotes
Antimicrob. Agents Chemother. 2004 48: 852-859. [Abstract] [Full Text] [PDF]  

Niilo Kaldalu, Rui Mei, and Kim Lewis

Killing by Ampicillin and Ofloxacin Induces Overlapping Changes in Escherichia coli Transcription Profile
Antimicrob. Agents Chemother. 2004 48: 890-896. [Abstract] [Full Text] [PDF]  

Thérèse Stachyra, Christophe Dini, Paul Ferrari, Ahmed Bouhss, Jean van Heijenoort, Dominique Mengin-Lecreulx, Didier Blanot, Jacques Biton, and Dominique Le Beller

Fluorescence Detection-Based Functional Assay for High-Throughput Screening for MraY
Antimicrob. Agents Chemother. 2004 48: 897-902. [Abstract] [Full Text] [PDF]  

Astrid Zervosen, Wei-Ping Lu, Zhouliang Chen, Ronald E. White, Thomas P. Demuth, Jr., and Jean-Marie Frère

Interactions between Penicillin-Binding Proteins (PBPs) and Two Novel Classes of PBP Inhibitors, Arylalkylidene Rhodanines and Arylalkylidene Iminothiazolidin-4-ones
Antimicrob. Agents Chemother. 2004 48: 961-969. [Abstract] [Full Text] [PDF]  

Jacqueline Chevalier, Jérôme Bredin, Abdallah Mahamoud, Monique Malléa, Jacques Barbe, and Jean-Marie Pagès

Inhibitors of Antibiotic Efflux in Resistant Enterobacter aerogenes and Klebsiella pneumoniae Strains
Antimicrob. Agents Chemother. 2004 48: 1043-1046. [Abstract] [Full Text] [PDF]  

Pilar Gutiérrez Navarro, Bartolomé Quintero Osso, Raquel García Ortiz, Pedro J. Martínez de las Parras, María I. Martínez Puentedura, and M. Carmen Cabeza González

Inhibition of ß-Lactamase II of Bacillus cereus by Penamaldic Derivatives of Penicillins
Antimicrob. Agents Chemother. 2004 48: 1058-1060. [Abstract] [Full Text] [PDF]  

Susceptibility:

Peter J. Petersen, T. Z. Wang, Russell G. Dushin, and Patricia A. Bradford

Comparative In Vitro Activities of AC98-6446, a Novel Semisynthetic Glycopeptide Derivative of the Natural Product Mannopeptimycin , and Other Antimicrobial Agents against Gram-Positive Clinical Isolates
Antimicrob. Agents Chemother. 2004 48: 739-746. [Abstract] [Full Text] [PDF]  

Areen Boulos, Jean-Marc Rolain, and Didier Raoult

Antibiotic Susceptibility of Tropheryma whipplei in MRC5 Cells
Antimicrob. Agents Chemother. 2004 48: 747-752. [Abstract] [Full Text] [PDF]  

Jimmy Yoon, Carl Urban, Christian Terzian, Noriel Mariano, and James J. Rahal

In Vitro Double and Triple Synergistic Activities of Polymyxin B, Imipenem, and Rifampin against Multidrug-Resistant Acinetobacter baumannii
Antimicrob. Agents Chemother. 2004 48: 753-757. [Abstract] [Full Text] [PDF]  

Alejandra Gomez-Flores, Oliverio Welsh, Salvador Said-Fernández, Gerardo Lozano-Garza, Roman Erick Tavarez-Alejandro, and Lucio Vera-Cabrera

In Vitro and In Vivo Activities of Antimicrobials against Nocardia brasiliensis
Antimicrob. Agents Chemother. 2004 48: 832-837. [Abstract] [Full Text] [PDF]  

Vladimír Buchta, Milan Pour, Petra Kubanová, Luis Silva, Ivan Votruba, Marie Voprsálová, Radan Schiller, Helena Fáková, and Marcel Spulák

In Vitro Activities of 3-(Halogenated Phenyl)-5-Acyloxymethyl- 2,5-Dihydrofuran-2-ones against Common and Emerging Yeasts and Molds
Antimicrob. Agents Chemother. 2004 48: 873-878. [Abstract] [Full Text] [PDF]  

Eric Dannaoui, Olivier Lortholary, and Françoise Dromer

In Vitro Evaluation of Double and Triple Combinations of Antifungal Drugs against Aspergillus fumigatus and Aspergillus terreus
Antimicrob. Agents Chemother. 2004 48: 970-978. [Abstract] [Full Text] [PDF]  

Ad C. Fluit, Franz-Josef Schmitz, Jan Verhoef, and Dana Milatovic

In Vitro Activity of Daptomycin against Gram-Positive European Clinical Isolates with Defined Resistance Determinants
Antimicrob. Agents Chemother. 2004 48: 1007-1011. [Abstract] [Full Text] [PDF]  

Charles E. Edmiston, Candace J. Krepel, Gary R. Seabrook, Lewis R. Somberg, Atilla Nakeeb, Robert A. Cambria, and Jonathan B. Towne

In Vitro Activities of Moxifloxacin against 900 Aerobic and Anaerobic Surgical Isolates from Patients with Intra-Abdominal and Diabetic Foot Infections
Antimicrob. Agents Chemother. 2004 48: 1012-1016. [Abstract] [Full Text] [PDF]  

N. V. Jacobus, L. A. McDermott, R. Ruthazer, and D. R. Snydman

In Vitro Activities of Tigecycline against the Bacteroides fragilis Group
Antimicrob. Agents Chemother. 2004 48: 1034-1036. [Abstract] [Full Text] [PDF]  

Lucio Vera-Cabrera, Elsa Y. Ochoa-Felix, Gloria Gonzalez, Rolando Tijerina, Sung H. Choi, and Oliverio Welsh

In Vitro Activities of New Quinolones and Oxazolidinones against Actinomadura madurae
Antimicrob. Agents Chemother. 2004 48: 1037-1039. [Abstract] [Full Text] [PDF]  

Rose Jung, Maroof Husain, Michael K. Choi, and Douglas N. Fish

Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii Clinical Isolates
Antimicrob. Agents Chemother. 2004 48: 1055-1057. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Laura K. Najvar, Anthony Cacciapuoti, Steve Hernandez, Judith Halpern, Rosie Bocanegra, Maya Gurnani, Frederick Menzel, David Loebenberg, and John R. Graybill

Activity of Posaconazole Combined with Amphotericin B against Aspergillus flavus Infection in Mice: Comparative Studies in Two Laboratories
Antimicrob. Agents Chemother. 2004 48: 758-764. [Abstract] [Full Text] [PDF]  

E. Azoulay-Dupuis, J. P. Bédos, J. Mohler, G. Peytavin, R. Isturiz, P. Moine, V. Rieux, C. Cherbuliez, J. C. Péchère, B. Fantin, and T. Köhler

Activities of Garenoxacin against Quinolone-Resistant Streptococcus pneumoniae Strains In Vitro and in a Mouse Pneumonia Model
Antimicrob. Agents Chemother. 2004 48: 765-773. [Abstract] [Full Text] [PDF]  

Hiroshi Hamamoto, Kenji Kurokawa, Chikara Kaito, Koushirou Kamura, Iony Manitra Razanajatovo, Hiroyuki Kusuhara, Tomofumi Santa, and Kazuhisa Sekimizu

Quantitative Evaluation of the Therapeutic Effects of Antibiotics Using Silkworms Infected with Human Pathogenic Microorganisms
Antimicrob. Agents Chemother. 2004 48: 774-779. [Abstract] [Full Text] [PDF]  

Araceli Parra, Carmen Ponte, Carlos Cenjor, Carmen Martínez-Marín, and Francisco Soriano

Effect of Antibiotic Treatment Delay on Therapeutic Outcome of Experimental Acute Otitis Media Caused by Streptococcus pneumoniae Strains with Different Susceptibilities to Amoxicillin
Antimicrob. Agents Chemother. 2004 48: 860-866. [Abstract] [Full Text] [PDF]  

Boubakar B. Ba, Hala Feghali, Corinne Arpin, Marie-Claude Saux, and Claudine Quentin

Activities of Ciprofloxacin and Moxifloxacin against Stenotrophomonas maltophilia and Emergence of Resistant Mutants in an In Vitro Pharmacokinetic-Pharmacodynamic Model
Antimicrob. Agents Chemother. 2004 48: 946-953. [Abstract] [Full Text] [PDF]  

Robert A. Larsen, Madeline Bauer, Ann M. Thomas, and J. Richard Graybill

Amphotericin B and Fluconazole, a Potent Combination Therapy for Cryptococcal Meningitis
Antimicrob. Agents Chemother. 2004 48: 985-991. [Abstract] [Full Text] [PDF]  

E. Dadachova, R. A. Bryan, A. Frenkel, T. Zhang, C. Apostolidis, J. S. Nosanchuk, J. D. Nosanchuk, and A. Casadevall

Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models
Antimicrob. Agents Chemother. 2004 48: 1004-1006. [Abstract] [Full Text] [PDF]  

Karl V. Clemons and David A. Stevens

Comparative Efficacies of Four Amphotericin B Formulations—Fungizone, Amphotec (Amphocil), AmBisome, and Abelcet—against Systemic Murine Aspergillosis
Antimicrob. Agents Chemother. 2004 48: 1047-1050. [Abstract] [Full Text] [PDF]  

Agnès Lefort, Juliette Pavie, Louis Garry, Françoise Chau, and Bruno Fantin

Activities of Dalbavancin In Vitro and in a Rabbit Model of Experimental Endocarditis Due to Staphylococcus aureus with or without Reduced Susceptibility to Vancomycin and Teicoplanin
Antimicrob. Agents Chemother. 2004 48: 1061-1064. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

Mathias W. R. Pletz, Andres De Roux, Andreas Roth, Karl-Heinz Neumann, Harald Mauch, and Hartmut Lode

Early Bactericidal Activity of Moxifloxacin in Treatment of Pulmonary Tuberculosis: a Prospective, Randomized Study
Antimicrob. Agents Chemother. 2004 48: 780-782. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Rahaman O. Suara and James E. Crowe, Jr.

Effect of Zinc Salts on Respiratory Syncytial Virus Replication
Antimicrob. Agents Chemother. 2004 48: 783-790. [Abstract] [Full Text] [PDF]  

Eric S. Furfine, Christopher T. Baker, Michael R. Hale, David J. Reynolds, Jo A. Salisbury, Andy D. Searle, Scott D. Studenberg, Dan Todd, Roger D. Tung, and Andrew Spaltenstein

Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir
Antimicrob. Agents Chemother. 2004 48: 791-798. [Abstract] [Full Text] [PDF]  

Diane T. Holland, Robin DiFrancesco, Judith Stone, Fayez Hamzeh, James D. Connor, and Gene D. Morse

Quality Assurance Program for Clinical Measurement of Antiretrovirals: AIDS Clinical Trials Group Proficiency Testing Program for Pediatric and Adult Pharmacology Laboratories
Antimicrob. Agents Chemother. 2004 48: 824-831. [Abstract] [Full Text] [PDF]  

Yu-Huan Li, Pei-Zhen Tao, Yu-Zhen Liu, and Jian-Dong Jiang

Geldanamycin, a Ligand of Heat Shock Protein 90, Inhibits the Replication of Herpes Simplex Virus Type 1 In Vitro
Antimicrob. Agents Chemother. 2004 48: 867-872. [Abstract] [Full Text] [PDF]  

Robert DiCenzo, Alan Forrest, Margaret A. Fischl, Ann Collier, Judith Feinberg, Heather Ribaudo, Robin DiFrancecso, and Gene D. Morse

Pharmacokinetics of Indinavir and Nelfinavir in Treatment-Naive, Human Immunodeficiency Virus-Infected Subjects
Antimicrob. Agents Chemother. 2004 48: 918-923. [Abstract] [Full Text] [PDF]  

Kirsten L. White, James M. Chen, Nicolas A. Margot, Terri Wrin, Christos J. Petropoulos, Lisa K. Naeger, S. Swaminathan, and Michael D. Miller

Molecular Mechanisms of Tenofovir Resistance Conferred by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing a Diserine Insertion after Residue 69 and Multiple Thymidine Analog-Associated Mutations
Antimicrob. Agents Chemother. 2004 48: 992-1003. [Abstract] [Full Text] [PDF]  

Hwijin Kim and John Yin

Quantitative Analysis of a Parasitic Antiviral Strategy
Antimicrob. Agents Chemother. 2004 48: 1017-1020. [Abstract] [Full Text] [PDF]  

Pharmacology:

Norihiro Hayashi, Yoshihiro Nakata, and Akira Yazaki

New Findings on the Structure-Phototoxicity Relationship and Photostability of Fluoroquinolones with Various Substituents at Position 1
Antimicrob. Agents Chemother. 2004 48: 799-803. [Abstract] [Full Text] [PDF]  

Rachel Courtney, Elaine Radwanski, Josephine Lim, and Mark Laughlin

Pharmacokinetics of Posaconazole Coadministered with Antacid in Fasting or Nonfasting Healthy Men
Antimicrob. Agents Chemother. 2004 48: 804-808. [Abstract] [Full Text] [PDF]  

Masami Sugie, Emiko Asakura, Ying Lan Zhao, Shoko Torita, Masayuki Nadai, Kenji Baba, Kiyoyuki Kitaichi, Kenji Takagi, Kenzo Takagi, and Takaaki Hasegawa

Possible Involvement of the Drug Transporters P Glycoprotein and Multidrug Resistance-Associated Protein Mrp2 in Disposition of Azithromycin
Antimicrob. Agents Chemother. 2004 48: 809-814. [Abstract] [Full Text] [PDF]  

Julie A. Stone, Xin Xu, Gregory A. Winchell, Paul J. Deutsch, Paul G. Pearson, Elizabeth M. Migoya, Goutam C. Mistry, Liwen Xi, Alisha Miller, Punam Sandhu, Romi Singh, Florencia deLuna, Stacy C. Dilzer, and Kenneth C. Lasseter

Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma
Antimicrob. Agents Chemother. 2004 48: 815-823. [Abstract] [Full Text] [PDF]  

Anton Leighton, Alice Bendix Gottlieb, Mary Beth Dorr, Daniela Jabes, Giorgio Mosconi, Claudia VanSaders, Edward J. Mroszczak, Kathleen C. M. Campbell, and Ellen Kelly

Tolerability, Pharmacokinetics, and Serum Bactericidal Activity of Intravenous Dalbavancin in Healthy Volunteers
Antimicrob. Agents Chemother. 2004 48: 940-945. [Abstract] [Full Text] [PDF]  

Paktiya Teja-Isavadharm, James O. Peggins, Thomas G. Brewer, Nicholas J. White, H. Kyle Webster, and Dennis E. Kyle

Plasmodium falciparum-Based Bioassay for Measurement of Artemisinin Derivatives in Plasma or Serum
Antimicrob. Agents Chemother. 2004 48: 954-960. [Abstract] [Full Text] [PDF]  

Richard C. Brundage, Florence H. Yong, Terence Fenton, Stephen A. Spector, Stuart E. Starr, and Courtney V. Fletcher

Intrapatient Variability of Efavirenz Concentrations as a Predictor of Virologic Response to Antiretroviral Therapy
Antimicrob. Agents Chemother. 2004 48: 979-984. [Abstract] [Full Text] [PDF]  

I. M. Rigter, H. G. Schipper, R. P. Koopmans, H. J. M. van Kan, H. W. Frijlink, P. A. Kager, and H.-J. Guchelaar

Relative Bioavailability of Three Newly Developed Albendazole Formulations: a Randomized Crossover Study with Healthy Volunteers
Antimicrob. Agents Chemother. 2004 48: 1051-1054. [Abstract] [Full Text] [PDF]  

Biologic Response Modifiers:

Maria Mamani-Matsuda, Jérôme Rambert, Denis Malvy, Hélène Lejoly-Boisseau, Sylvie Daulouède, Denis Thiolat, Sara Coves, Pierrette Courtois, Philippe Vincendeau, and M. Djavad Mossalayi

Quercetin Induces Apoptosis of Trypanosoma brucei gambiense and Decreases the Proinflammatory Response of Human Macrophages
Antimicrob. Agents Chemother. 2004 48: 924-929. [Abstract] [Full Text] [PDF]  

Chemistry; Biosynthesis:

Kapil Tahlan, Hyeon Ung Park, Annie Wong, Perrin H. Beatty, and Susan E. Jensen

Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in Streptomyces clavuligerus
Antimicrob. Agents Chemother. 2004 48: 930-939. [Abstract] [Full Text] [PDF]  

Letters:

Jean-Baptiste Stern, Philippe Girard, and Raffaele Caliandro

Pleural Diffusion of Voriconazole in a Patient with Aspergillus fumigatus Empyema Thoracis
Antimicrob. Agents Chemother. 2004 48: 1065. [Full Text] [PDF]  

Chris Wilkerson, Mansour Samadpour, Nicole van Kirk, and Marilyn C. Roberts

Antibiotic Resistance and Distribution of Tetracycline Resistance Genes in Escherichia coli O157:H7 Isolates from Humans and Bovines
Antimicrob. Agents Chemother. 2004 48: 1066-1067. [Full Text] [PDF]  

Marcela Radice, Pablo Power, Gabriel Gutkind, Karina Fernández, Carlos Vay, Angela Famiglietti, Nora Ricover, and Juan A. Ayala

First Class A Carbapenemase Isolated from Enterobacteriaceae in Argentina
Antimicrob. Agents Chemother. 2004 48: 1068-1069. [Full Text] [PDF]  

Errata:

Sang-Oh Lee, Nam Joong Kim, Sang-Ho Choi, Tae Hyong Kim, Jin-Won Chung, Jun-Hee Woo, Jiso Ryu, and Yang Soo Kim

Risk Factors for Acquisition of Imipenem-Resistant Acinetobacter baumannii: a Case-Control Study
Antimicrob. Agents Chemother. 2004 48: 1070. [Full Text] [PDF]  

Author's Correction:

T. M. Diaz-Guerra, E. Mellado, M. Cuenca-Estrella, and J. L. Rodriguez-Tudela

A Point Mutation in the 14-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus
Antimicrob. Agents Chemother. 2004 48: 1071. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.