Contents: May 2004, Volume 48, Issue 5        Minireviews        Mechanisms of Resistance        Mechanisms of Action        Antiviral Agents        Susceptibility        Experimental Therapeutics        Biologic Response Modifiers        Pharmacology        Analytical Procedures        Clinical Therapeutics        Chemistry; Biosynthesis        Letters        Author's Correction Other Issues

Table of Contents

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue Markus Müller, Amparo dela Peña, and Hartmut Derendorf Antimicrob. Agents Chemother. May 2004 48: 1441-1453; [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Role of a Mutation at Position 167 of CTX-M-19 in Ceftazidime Hydrolysis Soichiro Kimura, Masaji Ishiguro, Yoshikazu Ishii, Jimena Alba, and Keizo Yamaguchi Antimicrob. Agents Chemother. May 2004 48: 1454-1460; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapidly Increasing Prevalence of ß-Lactamase-Nonproducing, Ampicillin-Resistant Haemophilus influenzae Type b in Patients with Meningitis Keiko Hasegawa, Naoko Chiba, Reiko Kobayashi, Somay Y. Murayama, Satoshi Iwata, Keisuke Sunakawa, and Kimiko Ubukata Antimicrob. Agents Chemother. May 2004 48: 1509-1514; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Trypanocide Diminazene Aceturate Is Accumulated Predominantly through the TbAT1 Purine Transporter: Additional Insights on Diamidine Resistance in African Trypanosomes Harry P. de Koning, Laura F. Anderson, Mhairi Stewart, Richard J. S. Burchmore, Lynsey J. M. Wallace, and Michael P. Barrett Antimicrob. Agents Chemother. May 2004 48: 1515-1519; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Variety of ß-Lactamases Produced by Amoxicillin-Clavulanate-Resistant Escherichia coli Isolated in the Northeastern United States Keith S. Kaye, Howard S. Gold, Mitchell J. Schwaber, Lata Venkataraman, Youlin Qi, Paola C. De Girolami, Matthew H. Samore, Greg Anderson, J. Kamile Rasheed, and Fred C. Tenover Antimicrob. Agents Chemother. May 2004 48: 1520-1525; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Genomic Analysis of Fluconazole Susceptibility in the Pathogenic Yeast Candida glabrata: Roles of Calcium Signaling and Mitochondria Rupinder Kaur, Irene Castaño, and Brendan P. Cormack Antimicrob. Agents Chemother. May 2004 48: 1600-1613; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic and Molecular Characterization of ß-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae with Unusually High Resistance to Ampicillin Frank S. Kaczmarek, Thomas D. Gootz, Fadia Dib-Hajj, Wenchi Shang, Shawn Hallowell, and Melissa Cronan Antimicrob. Agents Chemother. May 2004 48: 1630-1639; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic and Biochemical Characterization of a Chromosome-Encoded Carbapenem-Hydrolyzing Ambler Class D ß-Lactamase from Shewanella algae Claire Héritier, Laurent Poirel, and Patrice Nordmann Antimicrob. Agents Chemother. May 2004 48: 1670-1675; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of the Multidrug Efflux System MexXY in the Emergence of Moderate Resistance to Aminoglycosides among Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis Christelle Vogne, Julio Ramos Aires, Christiane Bailly, Didier Hocquet, and Patrick Plésiat Antimicrob. Agents Chemother. May 2004 48: 1676-1680; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Increased Fluconazole Resistance in Candida glabrata during Prophylaxis John E. Bennett, Koichi Izumikawa, and Kieren A. Marr Antimicrob. Agents Chemother. May 2004 48: 1773-1777; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Membrane Sphingolipid-Ergosterol Interactions Are Important Determinants of Multidrug Resistance in Candida albicans Kasturi Mukhopadhyay, Tulika Prasad, Preeti Saini, Thomas J. Pucadyil, Amitabha Chattopadhyay, and Rajendra Prasad Antimicrob. Agents Chemother. May 2004 48: 1778-1787; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Azole Resistance in Petite Mutants of Candida glabrata Sophie Brun, Thierry Bergès, Pascal Poupard, Carole Vauzelle-Moreau, Gilles Renier, Dominique Chabasse, and Jean-Philippe Bouchara Antimicrob. Agents Chemother. May 2004 48: 1788-1796; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Strains of Pseudomonas aeruginosa Overproducing MexAB-OprM and MexXY Efflux Pumps Simultaneously Catherine Llanes, Didier Hocquet, Christelle Vogne, Dounia Benali-Baitich, Catherine Neuwirth, and Patrick Plésiat Antimicrob. Agents Chemother. May 2004 48: 1797-1802; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Non-mecA-Containing Staphylococcal Chromosomal Cassette Composite Island Containing pbp4 and tagF Genes in a Commensal Staphylococcal Species: a Possible Reservoir for Antibiotic Resistance Islands in Staphylococcus aureus Kanokporn Mongkolrattanothai, Susan Boyle, Trudy V. Murphy, and Robert S. Daum Antimicrob. Agents Chemother. May 2004 48: 1823-1836; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of Streptococcus pneumoniae Penicillin-Binding Protein 2b and Its Implication in ß-Lactam Resistance Estelle Pagliero, Laurent Chesnel, Julie Hopkins, Jacques Croizé, Otto Dideberg, Thierry Vernet, and Anne Marie Di Guilmi Antimicrob. Agents Chemother. May 2004 48: 1848-1855; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Analysis of the Effects of Chlorhexidine on Oral Biofilm Vitality and Structure Based on Viability Profiling and an Indicator of Membrane Integrity C. K. Hope and M. Wilson Antimicrob. Agents Chemother. May 2004 48: 1461-1468; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Activities of Rhodamine B-Conjugated Gelsolin-Derived Peptides Compared to Those of the Antimicrobial Peptides Cathelicidin LL37, Magainin II, and Melittin Robert Bucki, Jennifer J. Pastore, Paramjeet Randhawa, Rolands Vegners, Daniel J. Weiner, and Paul A. Janmey Antimicrob. Agents Chemother. May 2004 48: 1526-1533; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fungus-Elicited Metabolites from Plants as an Enriched Source for New Leishmanicidal Agents: Antifungal Phenyl-Phenalenone Phytoalexins from the Banana Plant (Musa acuminata) Target Mitochondria of Leishmania donovani Promastigotes Juan Román Luque-Ortega, Silvia Martínez, José María Saugar, Laura R. Izquierdo, Teresa Abad, Javier G. Luis, José Piñero, Basilio Valladares, and Luis Rivas Antimicrob. Agents Chemother. May 2004 48: 1534-1540; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Characterization of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase Losee L. Ling, Jun Xian, Syed Ali, Bolin Geng, Jun Fan, Debra M. Mills, Anthony C. Arvanites, Hernan Orgueira, Mark A. Ashwell, Gilles Carmel, Yibin Xiang, and Donald T. Moir Antimicrob. Agents Chemother. May 2004 48: 1541-1547; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biophysical Characterization of Endotoxin Inactivation by NK-2, an Antimicrobial Peptide Derived from Mammalian NK-Lysin Jörg Andrä, Michel H. J. Koch, Rainer Bartels, and Klaus Brandenburg Antimicrob. Agents Chemother. May 2004 48: 1593-1599; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Screening for Microtubule-Disrupting Antifungal Agents by Using a Mitotic-Arrest Mutant of Aspergillus nidulans and Novel Action of Phenylalanine Derivatives Accompanying Tubulin Loss Tetsuo Kiso, Ken-Ichi Fujita, Xu Ping, Toshio Tanaka, and Makoto Taniguchi Antimicrob. Agents Chemother. May 2004 48: 1739-1748; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase Steven Bellon, Jonathan D. Parsons, Yunyi Wei, Koto Hayakawa, Lora L. Swenson, Paul S. Charifson, Judith A. Lippke, Robert Aldape, and Christian H. Gross Antimicrob. Agents Chemother. May 2004 48: 1856-1864; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques Koen K. A. Van Rompay, Laurie L. Brignolo, Dennis J. Meyer, Christopher Jerome, Ross Tarara, Abigail Spinner, Marta Hamilton, Linda L. Hirst, David R. Bennett, Don R. Canfield, Trish G. Dearman, Wilhelm Von Morgenland, Phil C. Allen, Celia Valverde, Alesha B. Castillo, R. Bruce Martin, Valerie F. Samii, Ray Bendele, John Desjardins, Marta L. Marthas, Niels C. Pedersen, and Norbert Bischofberger Antimicrob. Agents Chemother. May 2004 48: 1469-1487; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Novel Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 against Human Parainfluenza Viruses In Vitro and In Vivo Irina V. Alymova, Garry Taylor, Toru Takimoto, Tsu-Hsing Lin, Pooran Chand, Y. Sudhakara Babu, Chenghong Li, Xiaoping Xiong, and Allen Portner Antimicrob. Agents Chemother. May 2004 48: 1495-1502; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Adjusted-Dose Lopinavir-Ritonavir Combined with Rifampin in Healthy Volunteers C. J. L. la Porte, E. P. H. Colbers, R. Bertz, D. S. Voncken, K. Wikstrom, M. J. Boeree, P. P. Koopmans, Y. A. Hekster, and D. M. Burger Antimicrob. Agents Chemother. May 2004 48: 1553-1560; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Drug Resistance Mutations L100I and V106A on the Binding of Pyrrolobenzoxazepinone Nonnucleoside Inhibitors to the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Catalytic Complex Giada A. Locatelli, Giuseppe Campiani, Reynel Cancio, Elena Morelli, Anna Ramunno, Sandra Gemma, Ulrich Hübscher, Silvio Spadari, and Giovanni Maga Antimicrob. Agents Chemother. May 2004 48: 1570-1580; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Polysulfated Galactose-Derivatized Dendrimers as Binding Antagonists of Human Immunodeficiency Virus Type 1 Infection Richard D. Kensinger, Bradley J. Catalone, Fred C. Krebs, Brian Wigdahl, and Cara-Lynne Schengrund Antimicrob. Agents Chemother. May 2004 48: 1614-1623; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel 4'-Substituted Stavudine Analog with Improved Anti-Human Immunodeficiency Virus Activity and Decreased Cytotoxicity Ginger E. Dutschman, Susan P. Grill, Elizabeth A. Gullen, Kazuhiro Haraguchi, Shingo Takeda, Hiromichi Tanaka, Masanori Baba, and Yung-Chi Cheng Antimicrob. Agents Chemother. May 2004 48: 1640-1646; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Action of the Ribopyranoside Benzimidazole GW275175X against Human Cytomegalovirus Mark R. Underwood, Robert G. Ferris, Dean W. Selleseth, Michelle G. Davis, John C. Drach, Leroy B. Townsend, Karen K. Biron, and F. Leslie Boyd Antimicrob. Agents Chemother. May 2004 48: 1647-1651; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bis-Anthracycline Antibiotics Inhibit Human Immunodeficiency Virus Type 1 Transcription Olaf Kutsch, David N. Levy, Paula J. Bates, Julie Decker, Barry R. Kosloff, George M. Shaw, W. Priebe, and Etty N. Benveniste Antimicrob. Agents Chemother. May 2004 48: 1652-1663; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Benzimidazole D- and L-Ribonucleosides in Animal Models of Cytomegalovirus Infections Earl R. Kern, Caroll B. Hartline, Rachel J. Rybak, John C. Drach, Leroy B. Townsend, Karen K. Biron, and Deborah J. Bidanset Antimicrob. Agents Chemother. May 2004 48: 1749-1755; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Expanded-Spectrum Pyridazinyl Oxime Ethers Related to Pirodavir: Novel Capsid-Binding Inhibitors with Potent Antipicornavirus Activity D. L. Barnard, V. D. Hubbard, D. F. Smee, R. W. Sidwell, K. G. W. Watson, S. P. T. Tucker, and P. A. R. Reece Antimicrob. Agents Chemother. May 2004 48: 1766-1772; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mouse Model of Cervicovaginal Toxicity and Inflammation for Preclinical Evaluation of Topical Vaginal Microbicides Bradley J. Catalone, Tina M. Kish-Catalone, Lynn R. Budgeon, Elizabeth B. Neely, Maelee Ferguson, Fred C. Krebs, Mary K. Howett, Mohamed Labib, Robert Rando, and Brian Wigdahl Antimicrob. Agents Chemother. May 2004 48: 1837-1847; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Natural Polymorphism of Cytomegalovirus DNA Polymerase Lies in Two Nonconserved Regions Located between Domains Delta-C and II and between Domains III and I Anne-Marie Fillet, Laetitia Auray, Sophie Alain, Karine Gourlain, Berthe Marie Imbert, Fatiha Najioullah, Gael Champier, Stéphanie Gouarin, Jocelyne Carquin, Nadhira Houhou, Isabelle Garrigue, Alexandra Ducancelle, Danielle Thouvenot, and Marie-Christine Mazeron Antimicrob. Agents Chemother. May 2004 48: 1865-1868; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro Kathy A. Keith, William B. Wan, Stephanie L. Ciesla, James R. Beadle, Karl Y. Hostetler, and Earl R. Kern Antimicrob. Agents Chemother. May 2004 48: 1869-1871; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Disposition and Metabolic Profiles of [14C]Viramidine and [14C]Ribavirin in Rat and Monkey Red Blood Cells and Liver Chin-Chung Lin, David Lourenco, Guifen Xu, and Li-Tain Yeh Antimicrob. Agents Chemother. May 2004 48: 1872-1875; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Expression Levels of MRP1, MRP4, and MRP5 in Response to Human Immunodeficiency Virus Infection in Human Macrophages Sylvie Jorajuria, Nathalie Dereuddre-Bosquet, Karen Naissant-Storck, Dominique Dormont, and Pascal Clayette Antimicrob. Agents Chemother. May 2004 48: 1889-1891; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Human Immunodeficiency Virus Type 1 Tat-trans-Activation-Responsive Region Interaction by an Antiviral Quinolone Derivative Sara Richter, Cristina Parolin, Barbara Gatto, Claudia Del Vecchio, Egidio Brocca-Cofano, Arnaldo Fravolini, Giorgio Palù, and Manlio Palumbo Antimicrob. Agents Chemother. May 2004 48: 1895-1899; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Maribavir and Selected Indolocarbazoles on Epstein-Barr Virus Protein Kinase BGLF4 and on Viral Lytic Replication Edward Gershburg, Ke Hong, and Joseph S. Pagano Antimicrob. Agents Chemother. May 2004 48: 1900-1903; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Indinavir Combined with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Children A. S. Bergshoeff, P. L. A. Fraaij, A. M. C. van Rossum, G. Verweel, L. H. Wynne, G. A. Winchell, R. Y. Leavitt, B.-Y. T. Nguyen, R. de Groot, and D. M. Burger Antimicrob. Agents Chemother. May 2004 48: 1904-1907; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002 Kimiko Ubukata, Naoko Chiba, Keiko Hasegawa, Reiko Kobayashi, Satoshi Iwata, and Keisuke Sunakawa Antimicrob. Agents Chemother. May 2004 48: 1488-1494; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Broth Microdilution Susceptibility Testing for Leptospira spp. Clinton K. Murray and Duane R. Hospenthal Antimicrob. Agents Chemother. May 2004 48: 1548-1552; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the ß-Lactamase Inhibitors Clavulanic Acid, Sulbactam, and Tazobactam Alone or in Combination with ß-Lactams against Epidemiologically Characterized Multidrug-Resistant Acinetobacter baumannii Strains Paul G. Higgins, Hilmar Wisplinghoff, Danuta Stefanik, and Harald Seifert Antimicrob. Agents Chemother. May 2004 48: 1586-1592; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus William J. Steinbach, Wiley A. Schell, Jill R. Blankenship, Chiatogu Onyewu, Joseph Heitman, and John R. Perfect Antimicrob. Agents Chemother. May 2004 48: 1664-1669; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening Martin Smilkstein, Nongluk Sriwilaijaroen, Jane Xu Kelly, Prapon Wilairat, and Michael Riscoe Antimicrob. Agents Chemother. May 2004 48: 1803-1806; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy Tyler N. Bennett, Michelle Paguio, Bojana Gligorijevic, Clement Seudieu, Andrew D. Kosar, Eugene Davidson, and Paul D. Roepe Antimicrob. Agents Chemother. May 2004 48: 1807-1810; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Colorimetric Assay for Antimicrobial Susceptibility Testing of Pseudomonas aeruginosa Michael M. Tunney, Gordon Ramage, Tyler R. Field, Thomas F. Moriarty, and Douglas G. Storey Antimicrob. Agents Chemother. May 2004 48: 1879-1881; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Telithromycin against 13,874 Streptococcus pneumoniae Isolates Collected between 1999 and 2003 David J. Farrell and David Felmingham Antimicrob. Agents Chemother. May 2004 48: 1882-1884; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of a Novel Diaminopyrimidine Compound, Iclaprim, against Chlamydia trachomatis and C. pneumoniae S. A. Kohlhoff, P. M. Roblin, T. Reznik, S. Hawser, K. Islam, and M. R. Hammerschlag Antimicrob. Agents Chemother. May 2004 48: 1885-1886; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Iron Blocks the Accumulation and Activity of Tetracyclines in Bacteria Angela M. Avery, Helen J. Goddard, Edward R. Sumner, and Simon V. Avery Antimicrob. Agents Chemother. May 2004 48: 1892-1894; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Anidulafungin against Selected Clinically Important Mold Isolates Zekaver Odabasi, Victor L. Paetznick, Jose R. Rodriguez, Enuo Chen, and Luis Ostrosky-Zeichner Antimicrob. Agents Chemother. May 2004 48: 1912-1915; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Prevention and Cure of Systemic Escherichia coli K1 Infection by Modification of the Bacterial Phenotype Naseem Mushtaq, Maria B. Redpath, J. Paul Luzio, and Peter W. Taylor Antimicrob. Agents Chemother. May 2004 48: 1503-1508; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antifungal Activities of Inhibitors of Phospholipases from the Fungal Pathogen Cryptococcus neoformans Ranjini Ganendren, Fred Widmer, Vatsala Singhal, Christabel Wilson, Tania Sorrell, and Lesley Wright Antimicrob. Agents Chemother. May 2004 48: 1561-1569; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Feasibility of Radioimmunotherapy of Experimental Pneumococcal Infection E. Dadachova, T. Burns, R. A. Bryan, C. Apostolidis, M. W. Brechbiel, J. D. Nosanchuk, A. Casadevall, and L. Pirofski Antimicrob. Agents Chemother. May 2004 48: 1624-1629; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pseudomonas aeruginosa LasA Protease in Treatment of Experimental Staphylococcal Keratitis Irina S. Barequet, Guy J. Ben Simon, Mary Safrin, Dennis E. Ohman, and Efrat Kessler Antimicrob. Agents Chemother. May 2004 48: 1681-1687; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Study of the Effects of Ceftizoxime, Piperacillin, and Piperacillin-Tazobactam Concentrations on Antibacterial Activity and Selection of Antibiotic-Resistant Mutants of Enterobacter cloacae and Bacteroides fragilis In Vitro and In Vivo in Mixed-Infection Abscesses Lorna E. T. Stearne, Doret van Boxtel, Nicole Lemmens, Wil H. F. Goessens, Johan W. Mouton, and Inge C. Gyssens Antimicrob. Agents Chemother. May 2004 48: 1688-1698; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy Delphine Croisier, Manuel Etienne, Emilie Bergoin, Pierre-Emmanuel Charles, Catherine Lequeu, Lionel Piroth, Henri Portier, and Pascal Chavanet Antimicrob. Agents Chemother. May 2004 48: 1699-1707; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy and Pharmacokinetics of AC98-6446, a Novel Cyclic Glycopeptide, in Experimental Infection Models William J. Weiss, Timothy Murphy, Eileen Lenoy, and Mairead Young Antimicrob. Agents Chemother. May 2004 48: 1708-1712; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rabbit Model of Candida albicans Biofilm Infection: Liposomal Amphotericin B Antifungal Lock Therapy Matthew K. Schinabeck, Lisa A. Long, Mohammad A. Hossain, Jyotsna Chandra, Pranab K. Mukherjee, Sotohy Mohamed, and Mahmoud A. Ghannoum Antimicrob. Agents Chemother. May 2004 48: 1727-1732; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trypanocidal Activity of Melamine-Based Nitroheterocycles Mhairi L. Stewart, Gorka Jimenez Bueno, Alessandro Baliani, Burkhard Klenke, Reto Brun, Janice M. Brock, Ian H. Gilbert, and Michael P. Barrett Antimicrob. Agents Chemother. May 2004 48: 1733-1738; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Respiratory Syncytial Virus (RSV) Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction, and Airway Hyperresponsiveness in a Murine RSV Model Asunción Mejías, Susana Chávez-Bueno, Ana María Ríos, Jesús Saavedra-Lozano, Mónica Fonseca Aten, Jeanine Hatfield, Payal Kapur, Ana María Gómez, Hasan S. Jafri, and Octavio Ramilo Antimicrob. Agents Chemother. May 2004 48: 1811-1822; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Virulence of Metallo-ß-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo S. Aoki, Y. Hirakata, A. Kondoh, N. Gotoh, K. Yanagihara, Y. Miyazaki, K. Tomono, Y. Yamada, S. Kohno, and S. Kamihira Antimicrob. Agents Chemother. May 2004 48: 1876-1878; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Inhalational Murine Model of Invasive Pulmonary Aspergillosis Donald C. Sheppard, Gunter Rieg, Lisa Y. Chiang, Scott G. Filler, John E. Edwards, Jr., and Ashraf S. Ibrahim Antimicrob. Agents Chemother. May 2004 48: 1908-1911; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Molecular Mechanisms of Anti-Inflammatory Action of Erythromycin in Human Bronchial Epithelial Cells: Possible Role in the Signaling Pathway That Regulates Nuclear Factor-B Activation Masashi Desaki, Hitoshi Okazaki, Toshiaki Sunazuka, Satoshi Omura, Kazuhiko Yamamoto, and Hajime Takizawa Antimicrob. Agents Chemother. May 2004 48: 1581-1585; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Use of Monte Carlo Simulations To Select Therapeutic Doses and Provisional Breakpoints of BAL9141 Johan W. Mouton, Anne Schmitt-Hoffmann, Stuart Shapiro, Norman Nashed, and Nieko C. Punt Antimicrob. Agents Chemother. May 2004 48: 1713-1718; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dose-Dependent Pharmacokinetics of Itraconazole after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect Jee H. Shin, Ka Y. Choi, Yu C. Kim, and Myung G. Lee Antimicrob. Agents Chemother. May 2004 48: 1756-1762; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Peritoneal Fluid Titer Test for Peritoneal Dialysis-Related Peritonitis Christine Strijack, Godfrey K. M. Harding, Robert E. Ariano, and Sheryl A. Zelenitsky Antimicrob. Agents Chemother. May 2004 48: 1719-1726; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Outcomes of Patients with Melioidosis Treated with Meropenem Allen C. Cheng, Dale A. Fisher, Nicholas M. Anstey, Dianne P. Stephens, Susan P. Jacups, and Bart J. Currie Antimicrob. Agents Chemother. May 2004 48: 1763-1765; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Development of a Liposome Formulation of Ethambutol Theresa Wiens, Thomas Redelmeier, and Yossef Av-Gay Antimicrob. Agents Chemother. May 2004 48: 1887-1888; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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International Spread of blaCMY-2-Mediated Cephalosporin Resistance in a Multiresistant Salmonella enterica Serovar Heidelberg Isolate Stemming from the Importation of a Boar by Denmark from Canada Frank M. Aarestrup, Henrik Hasman, Inger Olsen, and Gitte Sørensen Antimicrob. Agents Chemother. May 2004 48: 1916-1917; [Full Text] [PDF] [Reprints and Permissions]

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Author's Correction:

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In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria Dongeun Yong, Jong Hwa Yum, Kyungwon Lee, Yunsop Chong, Sung Hak Choi, and Jae Keol Rhee Antimicrob. Agents Chemother. May 2004 48: 1918 [Full Text] [PDF] [Reprints and Permissions]

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