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Minireviews:

Markus Müller, Amparo dela Peña, and Hartmut Derendorf

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue
Antimicrob. Agents Chemother. 2004 48: 1441-1453. [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Soichiro Kimura, Masaji Ishiguro, Yoshikazu Ishii, Jimena Alba, and Keizo Yamaguchi

Role of a Mutation at Position 167 of CTX-M-19 in Ceftazidime Hydrolysis
Antimicrob. Agents Chemother. 2004 48: 1454-1460. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Keiko Hasegawa, Naoko Chiba, Reiko Kobayashi, Somay Y. Murayama, Satoshi Iwata, Keisuke Sunakawa, and Kimiko Ubukata

Rapidly Increasing Prevalence of ß-Lactamase-Nonproducing, Ampicillin-Resistant Haemophilus influenzae Type b in Patients with Meningitis
Antimicrob. Agents Chemother. 2004 48: 1509-1514. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Harry P. de Koning, Laura F. Anderson, Mhairi Stewart, Richard J. S. Burchmore, Lynsey J. M. Wallace, and Michael P. Barrett

The Trypanocide Diminazene Aceturate Is Accumulated Predominantly through the TbAT1 Purine Transporter: Additional Insights on Diamidine Resistance in African Trypanosomes
Antimicrob. Agents Chemother. 2004 48: 1515-1519. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Keith S. Kaye, Howard S. Gold, Mitchell J. Schwaber, Lata Venkataraman, Youlin Qi, Paola C. De Girolami, Matthew H. Samore, Greg Anderson, J. Kamile Rasheed, and Fred C. Tenover

Variety of ß-Lactamases Produced by Amoxicillin-Clavulanate-Resistant Escherichia coli Isolated in the Northeastern United States
Antimicrob. Agents Chemother. 2004 48: 1520-1525. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rupinder Kaur, Irene Castaño, and Brendan P. Cormack

Functional Genomic Analysis of Fluconazole Susceptibility in the Pathogenic Yeast Candida glabrata: Roles of Calcium Signaling and Mitochondria
Antimicrob. Agents Chemother. 2004 48: 1600-1613. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Frank S. Kaczmarek, Thomas D. Gootz, Fadia Dib-Hajj, Wenchi Shang, Shawn Hallowell, and Melissa Cronan

Genetic and Molecular Characterization of ß-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae with Unusually High Resistance to Ampicillin
Antimicrob. Agents Chemother. 2004 48: 1630-1639. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Claire Héritier, Laurent Poirel, and Patrice Nordmann

Genetic and Biochemical Characterization of a Chromosome-Encoded Carbapenem-Hydrolyzing Ambler Class D ß-Lactamase from Shewanella algae
Antimicrob. Agents Chemother. 2004 48: 1670-1675. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christelle Vogne, Julio Ramos Aires, Christiane Bailly, Didier Hocquet, and Patrick Plésiat

Role of the Multidrug Efflux System MexXY in the Emergence of Moderate Resistance to Aminoglycosides among Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis
Antimicrob. Agents Chemother. 2004 48: 1676-1680. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John E. Bennett, Koichi Izumikawa, and Kieren A. Marr

Mechanism of Increased Fluconazole Resistance in Candida glabrata during Prophylaxis
Antimicrob. Agents Chemother. 2004 48: 1773-1777. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kasturi Mukhopadhyay, Tulika Prasad, Preeti Saini, Thomas J. Pucadyil, Amitabha Chattopadhyay, and Rajendra Prasad

Membrane Sphingolipid-Ergosterol Interactions Are Important Determinants of Multidrug Resistance in Candida albicans
Antimicrob. Agents Chemother. 2004 48: 1778-1787. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sophie Brun, Thierry Bergès, Pascal Poupard, Carole Vauzelle-Moreau, Gilles Renier, Dominique Chabasse, and Jean-Philippe Bouchara

Mechanisms of Azole Resistance in Petite Mutants of Candida glabrata
Antimicrob. Agents Chemother. 2004 48: 1788-1796. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Catherine Llanes, Didier Hocquet, Christelle Vogne, Dounia Benali-Baitich, Catherine Neuwirth, and Patrick Plésiat

Clinical Strains of Pseudomonas aeruginosa Overproducing MexAB-OprM and MexXY Efflux Pumps Simultaneously
Antimicrob. Agents Chemother. 2004 48: 1797-1802. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kanokporn Mongkolrattanothai, Susan Boyle, Trudy V. Murphy, and Robert S. Daum

Novel Non-mecA-Containing Staphylococcal Chromosomal Cassette Composite Island Containing pbp4 and tagF Genes in a Commensal Staphylococcal Species: a Possible Reservoir for Antibiotic Resistance Islands in Staphylococcus aureus
Antimicrob. Agents Chemother. 2004 48: 1823-1836. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Estelle Pagliero, Laurent Chesnel, Julie Hopkins, Jacques Croizé, Otto Dideberg, Thierry Vernet, and Anne Marie Di Guilmi

Biochemical Characterization of Streptococcus pneumoniae Penicillin-Binding Protein 2b and Its Implication in ß-Lactam Resistance
Antimicrob. Agents Chemother. 2004 48: 1848-1855. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

C. K. Hope and M. Wilson

Analysis of the Effects of Chlorhexidine on Oral Biofilm Vitality and Structure Based on Viability Profiling and an Indicator of Membrane Integrity
Antimicrob. Agents Chemother. 2004 48: 1461-1468. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robert Bucki, Jennifer J. Pastore, Paramjeet Randhawa, Rolands Vegners, Daniel J. Weiner, and Paul A. Janmey

Antibacterial Activities of Rhodamine B-Conjugated Gelsolin-Derived Peptides Compared to Those of the Antimicrobial Peptides Cathelicidin LL37, Magainin II, and Melittin
Antimicrob. Agents Chemother. 2004 48: 1526-1533. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Juan Román Luque-Ortega, Silvia Martínez, José María Saugar, Laura R. Izquierdo, Teresa Abad, Javier G. Luis, José Piñero, Basilio Valladares, and Luis Rivas

Fungus-Elicited Metabolites from Plants as an Enriched Source for New Leishmanicidal Agents: Antifungal Phenyl-Phenalenone Phytoalexins from the Banana Plant (Musa acuminata) Target Mitochondria of Leishmania donovani Promastigotes
Antimicrob. Agents Chemother. 2004 48: 1534-1540. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Losee L. Ling, Jun Xian, Syed Ali, Bolin Geng, Jun Fan, Debra M. Mills, Anthony C. Arvanites, Hernan Orgueira, Mark A. Ashwell, Gilles Carmel, Yibin Xiang, and Donald T. Moir

Identification and Characterization of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase
Antimicrob. Agents Chemother. 2004 48: 1541-1547. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jörg Andrä, Michel H. J. Koch, Rainer Bartels, and Klaus Brandenburg

Biophysical Characterization of Endotoxin Inactivation by NK-2, an Antimicrobial Peptide Derived from Mammalian NK-Lysin
Antimicrob. Agents Chemother. 2004 48: 1593-1599. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tetsuo Kiso, Ken-Ichi Fujita, Xu Ping, Toshio Tanaka, and Makoto Taniguchi

Screening for Microtubule-Disrupting Antifungal Agents by Using a Mitotic-Arrest Mutant of Aspergillus nidulans and Novel Action of Phenylalanine Derivatives Accompanying Tubulin Loss
Antimicrob. Agents Chemother. 2004 48: 1739-1748. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Steven Bellon, Jonathan D. Parsons, Yunyi Wei, Koto Hayakawa, Lora L. Swenson, Paul S. Charifson, Judith A. Lippke, Robert Aldape, and Christian H. Gross

Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase
Antimicrob. Agents Chemother. 2004 48: 1856-1864. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Koen K. A. Van Rompay, Laurie L. Brignolo, Dennis J. Meyer, Christopher Jerome, Ross Tarara, Abigail Spinner, Marta Hamilton, Linda L. Hirst, David R. Bennett, Don R. Canfield, Trish G. Dearman, Wilhelm Von Morgenland, Phil C. Allen, Celia Valverde, Alesha B. Castillo, R. Bruce Martin, Valerie F. Samii, Ray Bendele, John Desjardins, Marta L. Marthas, Niels C. Pedersen, and Norbert Bischofberger

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques
Antimicrob. Agents Chemother. 2004 48: 1469-1487. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Irina V. Alymova, Garry Taylor, Toru Takimoto, Tsu-Hsing Lin, Pooran Chand, Y. Sudhakara Babu, Chenghong Li, Xiaoping Xiong, and Allen Portner

Efficacy of Novel Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 against Human Parainfluenza Viruses In Vitro and In Vivo
Antimicrob. Agents Chemother. 2004 48: 1495-1502. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

C. J. L. la Porte, E. P. H. Colbers, R. Bertz, D. S. Voncken, K. Wikstrom, M. J. Boeree, P. P. Koopmans, Y. A. Hekster, and D. M. Burger

Pharmacokinetics of Adjusted-Dose Lopinavir-Ritonavir Combined with Rifampin in Healthy Volunteers
Antimicrob. Agents Chemother. 2004 48: 1553-1560. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Giada A. Locatelli, Giuseppe Campiani, Reynel Cancio, Elena Morelli, Anna Ramunno, Sandra Gemma, Ulrich Hübscher, Silvio Spadari, and Giovanni Maga

Effects of Drug Resistance Mutations L100I and V106A on the Binding of Pyrrolobenzoxazepinone Nonnucleoside Inhibitors to the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Catalytic Complex
Antimicrob. Agents Chemother. 2004 48: 1570-1580. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Richard D. Kensinger, Bradley J. Catalone, Fred C. Krebs, Brian Wigdahl, and Cara-Lynne Schengrund

Novel Polysulfated Galactose-Derivatized Dendrimers as Binding Antagonists of Human Immunodeficiency Virus Type 1 Infection
Antimicrob. Agents Chemother. 2004 48: 1614-1623. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ginger E. Dutschman, Susan P. Grill, Elizabeth A. Gullen, Kazuhiro Haraguchi, Shingo Takeda, Hiromichi Tanaka, Masanori Baba, and Yung-Chi Cheng

Novel 4'-Substituted Stavudine Analog with Improved Anti-Human Immunodeficiency Virus Activity and Decreased Cytotoxicity
Antimicrob. Agents Chemother. 2004 48: 1640-1646. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mark R. Underwood, Robert G. Ferris, Dean W. Selleseth, Michelle G. Davis, John C. Drach, Leroy B. Townsend, Karen K. Biron, and F. Leslie Boyd

Mechanism of Action of the Ribopyranoside Benzimidazole GW275175X against Human Cytomegalovirus
Antimicrob. Agents Chemother. 2004 48: 1647-1651. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olaf Kutsch, David N. Levy, Paula J. Bates, Julie Decker, Barry R. Kosloff, George M. Shaw, W. Priebe, and Etty N. Benveniste

Bis-Anthracycline Antibiotics Inhibit Human Immunodeficiency Virus Type 1 Transcription
Antimicrob. Agents Chemother. 2004 48: 1652-1663. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Earl R. Kern, Caroll B. Hartline, Rachel J. Rybak, John C. Drach, Leroy B. Townsend, Karen K. Biron, and Deborah J. Bidanset

Activities of Benzimidazole D- and L-Ribonucleosides in Animal Models of Cytomegalovirus Infections
Antimicrob. Agents Chemother. 2004 48: 1749-1755. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

D. L. Barnard, V. D. Hubbard, D. F. Smee, R. W. Sidwell, K. G. W. Watson, S. P. T. Tucker, and P. A. R. Reece

In Vitro Activity of Expanded-Spectrum Pyridazinyl Oxime Ethers Related to Pirodavir: Novel Capsid-Binding Inhibitors with Potent Antipicornavirus Activity
Antimicrob. Agents Chemother. 2004 48: 1766-1772. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Bradley J. Catalone, Tina M. Kish-Catalone, Lynn R. Budgeon, Elizabeth B. Neely, Maelee Ferguson, Fred C. Krebs, Mary K. Howett, Mohamed Labib, Robert Rando, and Brian Wigdahl

Mouse Model of Cervicovaginal Toxicity and Inflammation for Preclinical Evaluation of Topical Vaginal Microbicides
Antimicrob. Agents Chemother. 2004 48: 1837-1847. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anne-Marie Fillet, Laetitia Auray, Sophie Alain, Karine Gourlain, Berthe Marie Imbert, Fatiha Najioullah, Gael Champier, Stéphanie Gouarin, Jocelyne Carquin, Nadhira Houhou, Isabelle Garrigue, Alexandra Ducancelle, Danielle Thouvenot, and Marie-Christine Mazeron

Natural Polymorphism of Cytomegalovirus DNA Polymerase Lies in Two Nonconserved Regions Located between Domains Delta-C and II and between Domains III and I
Antimicrob. Agents Chemother. 2004 48: 1865-1868. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kathy A. Keith, William B. Wan, Stephanie L. Ciesla, James R. Beadle, Karl Y. Hostetler, and Earl R. Kern

Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro
Antimicrob. Agents Chemother. 2004 48: 1869-1871. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chin-Chung Lin, David Lourenco, Guifen Xu, and Li-Tain Yeh

Disposition and Metabolic Profiles of [¹⁴C]Viramidine and [¹⁴C]Ribavirin in Rat and Monkey Red Blood Cells and Liver
Antimicrob. Agents Chemother. 2004 48: 1872-1875. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sylvie Jorajuria, Nathalie Dereuddre-Bosquet, Karen Naissant-Storck, Dominique Dormont, and Pascal Clayette

Differential Expression Levels of MRP1, MRP4, and MRP5 in Response to Human Immunodeficiency Virus Infection in Human Macrophages
Antimicrob. Agents Chemother. 2004 48: 1889-1891. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sara Richter, Cristina Parolin, Barbara Gatto, Claudia Del Vecchio, Egidio Brocca-Cofano, Arnaldo Fravolini, Giorgio Palù, and Manlio Palumbo

Inhibition of Human Immunodeficiency Virus Type 1 Tat-trans-Activation-Responsive Region Interaction by an Antiviral Quinolone Derivative
Antimicrob. Agents Chemother. 2004 48: 1895-1899. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Edward Gershburg, Ke Hong, and Joseph S. Pagano

Effects of Maribavir and Selected Indolocarbazoles on Epstein-Barr Virus Protein Kinase BGLF4 and on Viral Lytic Replication
Antimicrob. Agents Chemother. 2004 48: 1900-1903. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. S. Bergshoeff, P. L. A. Fraaij, A. M. C. van Rossum, G. Verweel, L. H. Wynne, G. A. Winchell, R. Y. Leavitt, B.-Y. T. Nguyen, R. de Groot, and D. M. Burger

Pharmacokinetics of Indinavir Combined with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Children
Antimicrob. Agents Chemother. 2004 48: 1904-1907. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Kimiko Ubukata, Naoko Chiba, Keiko Hasegawa, Reiko Kobayashi, Satoshi Iwata, and Keisuke Sunakawa

Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002
Antimicrob. Agents Chemother. 2004 48: 1488-1494. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinton K. Murray and Duane R. Hospenthal

Broth Microdilution Susceptibility Testing for Leptospira spp.
Antimicrob. Agents Chemother. 2004 48: 1548-1552. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paul G. Higgins, Hilmar Wisplinghoff, Danuta Stefanik, and Harald Seifert

In Vitro Activities of the ß-Lactamase Inhibitors Clavulanic Acid, Sulbactam, and Tazobactam Alone or in Combination with ß-Lactams against Epidemiologically Characterized Multidrug-Resistant Acinetobacter baumannii Strains
Antimicrob. Agents Chemother. 2004 48: 1586-1592. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

William J. Steinbach, Wiley A. Schell, Jill R. Blankenship, Chiatogu Onyewu, Joseph Heitman, and John R. Perfect

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus
Antimicrob. Agents Chemother. 2004 48: 1664-1669. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Martin Smilkstein, Nongluk Sriwilaijaroen, Jane Xu Kelly, Prapon Wilairat, and Michael Riscoe

Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening
Antimicrob. Agents Chemother. 2004 48: 1803-1806. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tyler N. Bennett, Michelle Paguio, Bojana Gligorijevic, Clement Seudieu, Andrew D. Kosar, Eugene Davidson, and Paul D. Roepe

Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy
Antimicrob. Agents Chemother. 2004 48: 1807-1810. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael M. Tunney, Gordon Ramage, Tyler R. Field, Thomas F. Moriarty, and Douglas G. Storey

Rapid Colorimetric Assay for Antimicrobial Susceptibility Testing of Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2004 48: 1879-1881. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David J. Farrell and David Felmingham

Activities of Telithromycin against 13,874 Streptococcus pneumoniae Isolates Collected between 1999 and 2003
Antimicrob. Agents Chemother. 2004 48: 1882-1884. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. A. Kohlhoff, P. M. Roblin, T. Reznik, S. Hawser, K. Islam, and M. R. Hammerschlag

In Vitro Activity of a Novel Diaminopyrimidine Compound, Iclaprim, against Chlamydia trachomatis and C. pneumoniae
Antimicrob. Agents Chemother. 2004 48: 1885-1886. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Angela M. Avery, Helen J. Goddard, Edward R. Sumner, and Simon V. Avery

Iron Blocks the Accumulation and Activity of Tetracyclines in Bacteria
Antimicrob. Agents Chemother. 2004 48: 1892-1894. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Zekaver Odabasi, Victor L. Paetznick, Jose R. Rodriguez, Enuo Chen, and Luis Ostrosky-Zeichner

In Vitro Activity of Anidulafungin against Selected Clinically Important Mold Isolates
Antimicrob. Agents Chemother. 2004 48: 1912-1915. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Naseem Mushtaq, Maria B. Redpath, J. Paul Luzio, and Peter W. Taylor

Prevention and Cure of Systemic Escherichia coli K1 Infection by Modification of the Bacterial Phenotype
Antimicrob. Agents Chemother. 2004 48: 1503-1508. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ranjini Ganendren, Fred Widmer, Vatsala Singhal, Christabel Wilson, Tania Sorrell, and Lesley Wright

In Vitro Antifungal Activities of Inhibitors of Phospholipases from the Fungal Pathogen Cryptococcus neoformans
Antimicrob. Agents Chemother. 2004 48: 1561-1569. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

E. Dadachova, T. Burns, R. A. Bryan, C. Apostolidis, M. W. Brechbiel, J. D. Nosanchuk, A. Casadevall, and L. Pirofski

Feasibility of Radioimmunotherapy of Experimental Pneumococcal Infection
Antimicrob. Agents Chemother. 2004 48: 1624-1629. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Irina S. Barequet, Guy J. Ben Simon, Mary Safrin, Dennis E. Ohman, and Efrat Kessler

Pseudomonas aeruginosa LasA Protease in Treatment of Experimental Staphylococcal Keratitis
Antimicrob. Agents Chemother. 2004 48: 1681-1687. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lorna E. T. Stearne, Doret van Boxtel, Nicole Lemmens, Wil H. F. Goessens, Johan W. Mouton, and Inge C. Gyssens

Comparative Study of the Effects of Ceftizoxime, Piperacillin, and Piperacillin-Tazobactam Concentrations on Antibacterial Activity and Selection of Antibiotic-Resistant Mutants of Enterobacter cloacae and Bacteroides fragilis In Vitro and In Vivo in Mixed-Infection Abscesses
Antimicrob. Agents Chemother. 2004 48: 1688-1698. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Delphine Croisier, Manuel Etienne, Emilie Bergoin, Pierre-Emmanuel Charles, Catherine Lequeu, Lionel Piroth, Henri Portier, and Pascal Chavanet

Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy
Antimicrob. Agents Chemother. 2004 48: 1699-1707. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

William J. Weiss, Timothy Murphy, Eileen Lenoy, and Mairead Young

In Vivo Efficacy and Pharmacokinetics of AC98-6446, a Novel Cyclic Glycopeptide, in Experimental Infection Models
Antimicrob. Agents Chemother. 2004 48: 1708-1712. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Matthew K. Schinabeck, Lisa A. Long, Mohammad A. Hossain, Jyotsna Chandra, Pranab K. Mukherjee, Sotohy Mohamed, and Mahmoud A. Ghannoum

Rabbit Model of Candida albicans Biofilm Infection: Liposomal Amphotericin B Antifungal Lock Therapy
Antimicrob. Agents Chemother. 2004 48: 1727-1732. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mhairi L. Stewart, Gorka Jimenez Bueno, Alessandro Baliani, Burkhard Klenke, Reto Brun, Janice M. Brock, Ian H. Gilbert, and Michael P. Barrett

Trypanocidal Activity of Melamine-Based Nitroheterocycles
Antimicrob. Agents Chemother. 2004 48: 1733-1738. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Asunción Mejías, Susana Chávez-Bueno, Ana María Ríos, Jesús Saavedra-Lozano, Mónica Fonseca Aten, Jeanine Hatfield, Payal Kapur, Ana María Gómez, Hasan S. Jafri, and Octavio Ramilo

Anti-Respiratory Syncytial Virus (RSV) Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction, and Airway Hyperresponsiveness in a Murine RSV Model
Antimicrob. Agents Chemother. 2004 48: 1811-1822. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. Aoki, Y. Hirakata, A. Kondoh, N. Gotoh, K. Yanagihara, Y. Miyazaki, K. Tomono, Y. Yamada, S. Kohno, and S. Kamihira

Virulence of Metallo-ß-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo
Antimicrob. Agents Chemother. 2004 48: 1876-1878. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Donald C. Sheppard, Gunter Rieg, Lisa Y. Chiang, Scott G. Filler, John E. Edwards, Jr., and Ashraf S. Ibrahim

Novel Inhalational Murine Model of Invasive Pulmonary Aspergillosis
Antimicrob. Agents Chemother. 2004 48: 1908-1911. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Masashi Desaki, Hitoshi Okazaki, Toshiaki Sunazuka, Satoshi Omura, Kazuhiko Yamamoto, and Hajime Takizawa

Molecular Mechanisms of Anti-Inflammatory Action of Erythromycin in Human Bronchial Epithelial Cells: Possible Role in the Signaling Pathway That Regulates Nuclear Factor-B Activation
Antimicrob. Agents Chemother. 2004 48: 1581-1585. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Johan W. Mouton, Anne Schmitt-Hoffmann, Stuart Shapiro, Norman Nashed, and Nieko C. Punt

Use of Monte Carlo Simulations To Select Therapeutic Doses and Provisional Breakpoints of BAL9141
Antimicrob. Agents Chemother. 2004 48: 1713-1718. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jee H. Shin, Ka Y. Choi, Yu C. Kim, and Myung G. Lee

Dose-Dependent Pharmacokinetics of Itraconazole after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect
Antimicrob. Agents Chemother. 2004 48: 1756-1762. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Analytical Procedures:

Christine Strijack, Godfrey K. M. Harding, Robert E. Ariano, and Sheryl A. Zelenitsky

Peritoneal Fluid Titer Test for Peritoneal Dialysis-Related Peritonitis
Antimicrob. Agents Chemother. 2004 48: 1719-1726. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

Allen C. Cheng, Dale A. Fisher, Nicholas M. Anstey, Dianne P. Stephens, Susan P. Jacups, and Bart J. Currie

Outcomes of Patients with Melioidosis Treated with Meropenem
Antimicrob. Agents Chemother. 2004 48: 1763-1765. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chemistry; Biosynthesis:

Theresa Wiens, Thomas Redelmeier, and Yossef Av-Gay

Development of a Liposome Formulation of Ethambutol
Antimicrob. Agents Chemother. 2004 48: 1887-1888. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Frank M. Aarestrup, Henrik Hasman, Inger Olsen, and Gitte Sørensen

International Spread of bla_CMY-2-Mediated Cephalosporin Resistance in a Multiresistant Salmonella enterica Serovar Heidelberg Isolate Stemming from the Importation of a Boar by Denmark from Canada
Antimicrob. Agents Chemother. 2004 48: 1916-1917. [Full Text] [PDF] [Reprints and Permissions]  

Author's Correction:

Dongeun Yong, Jong Hwa Yum, Kyungwon Lee, Yunsop Chong, Sung Hak Choi, and Jae Keol Rhee

In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria
Antimicrob. Agents Chemother. 2004 48: 1918. [Full Text] [PDF] [Reprints and Permissions]  

Debra C. Quenelle, Deborah J. Collins, W. Brad Wan, James R. Beadle, Karl Y. Hostetler, and Earl R. Kern

Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir
Antimicrob. Agents Chemother. 2004 48: 1919. [Full Text] [PDF] [Reprints and Permissions]  

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