Contents: August 2004, Volume 48, Issue 8        Minireviews        Clinical Therapeutics        Mechanisms of Resistance        Mechanisms of Action        Antiviral Agents        Susceptibility        Experimental Therapeutics        Pharmacology        Biologic Response Modifiers        Chemistry; Biosynthesis        Letters        Author's Correction        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Hazard Ratio in Clinical Trials Spotswood L. Spruance, Julia E. Reid, Michael Grace, and Matthew Samore Antimicrob. Agents Chemother. August 2004 48: 2787-2792; [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Comparative Effects of Ciprofloxacin and Ceftazidime on Cytokine Production in Patients with Severe Sepsis Caused by Gram-Negative Bacteria C. A. Gogos, A. Skoutelis, A. Lekkou, E. Drosou, I. Starakis, M. N. Marangos, and H. P. Bassaris Antimicrob. Agents Chemother. August 2004 48: 2793-2798; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Daptomycin Barry Dvorchik, Robert D. Arbeit, Julia Chung, Susan Liu, William Knebel, and Helen Kastrissios Antimicrob. Agents Chemother. August 2004 48: 2799-2807; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of an Antibiotic Cycling Program on Antibiotic Prescribing Practices in an Intensive Care Unit Liana R. Merz, David K. Warren, Marin H. Kollef, and Victoria J. Fraser Antimicrob. Agents Chemother. August 2004 48: 2861-2865; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pilot Randomized Double-Blind Trial of Treatment of Mycobacterium ulcerans Disease (Buruli Ulcer) with Topical Nitrogen Oxides R. Phillips, O. Adjei, S. Lucas, N. Benjamin, and M. Wansbrough-Jones Antimicrob. Agents Chemother. August 2004 48: 2866-2870; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Amoxicillin Use on Oral Microbiota in Young Children D. Ready, H. Lancaster, F. Qureshi, R. Bedi, P. Mullany, and M. Wilson Antimicrob. Agents Chemother. August 2004 48: 2883-2887; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Intravenous Itraconazole in Stable Hemodialysis Patients John F. Mohr, Kevin W. Finkel, John H. Rex, Jose R. Rodriguez, Gerhard J. Leitz, and Luis Ostrosky-Zeichner Antimicrob. Agents Chemother. August 2004 48: 3151-3153; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Multiple Outbreaks of Nosocomial Salmonellosis in Russia and Belarus Caused by a Single Clone of Salmonella enterica Serovar Typhimurium Producing an Extended-Spectrum ß-Lactamase M. Edelstein, M. Pimkin, T. Dmitrachenko, V. Semenov, N. Kozlova, D. Gladin, A. Baraniak, and L. Stratchounski Antimicrob. Agents Chemother. August 2004 48: 2808-2815; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

DNA Sequence Analysis of Regions Surrounding blaCMY-2 from Multiple Salmonella Plasmid Backbones W. P. Giles, A. K. Benson, M. E. Olson, R. W. Hutkins, J. M. Whichard, P. L. Winokur, and P. D. Fey Antimicrob. Agents Chemother. August 2004 48: 2845-2852; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of a Cephamycin-Hydrolyzing and Inhibitor-Resistant Class A ß-Lactamase, GES-4, Possessing a Single G170S Substitution in the -Loop Jun-ichi Wachino, Yohei Doi, Kunikazu Yamane, Naohiro Shibata, Tetsuya Yagi, Takako Kubota, and Yoshichika Arakawa Antimicrob. Agents Chemother. August 2004 48: 2905-2910; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Real-Time PCR Genotyping of Mutations Associated with Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum Alisa P. Alker, Victor Mwapasa, and Steven R. Meshnick Antimicrob. Agents Chemother. August 2004 48: 2924-2929; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Modulation of Fibronectin Adhesins and Other Virulence Factors in a Teicoplanin-Resistant Derivative of Methicillin-Resistant Staphylococcus aureus Adriana Renzoni, Patrice Francois, Dongmei Li, William L. Kelley, Daniel P. Lew, Pierre Vaudaux, and Jacques Schrenzel Antimicrob. Agents Chemother. August 2004 48: 2958-2965; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Different Fluoroquinolones against Bacillus anthracis Mutants Selected In Vitro and Harboring Topoisomerase Mutations Patrick Grohs, Isabelle Podglajen, and Laurent Gutmann Antimicrob. Agents Chemother. August 2004 48: 3024-3027; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Specific pbp5 Mutations on Expression of ß-Lactam Resistance in Enterococcus faecium Louis B. Rice, Samuel Bellais, Lenore L. Carias, Rebecca Hutton-Thomas, Robert A. Bonomo, Patrick Caspers, Malcolm G. P. Page, and Laurent Gutmann Antimicrob. Agents Chemother. August 2004 48: 3028-3032; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Gene Expression Profiles of Candida albicans Azole-Resistant Clinical Isolates and Laboratory Strains Exposed to Drugs Inducing Multidrug Transporters Mahir Karababa, Alix T. Coste, Bénédicte Rognon, Jacques Bille, and Dominique Sanglard Antimicrob. Agents Chemother. August 2004 48: 3064-3079; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Polymorphisms in mec Genes and a New mec Complex Type in Methicillin-Resistant Staphylococcus aureus Isolates Obtained in Rural Wisconsin Sanjay K. Shukla, Srinivas V. Ramaswamy, Jennifer Conradt, Mary E. Stemper, Robert Reich, Kurt D. Reed, and Edward A. Graviss Antimicrob. Agents Chemother. August 2004 48: 3080-3085; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence in Italy of a Neisseria meningitidis Clone with Decreased Susceptibility to Penicillin Paola Stefanelli, Cecilia Fazio, Arianna Neri, Tonino Sofia, and Paola Mastrantonio Antimicrob. Agents Chemother. August 2004 48: 3103-3106; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of Evidence that DNA in Antibiotic Preparations Is a Source of Antibiotic Resistance Genes in Bacteria from Animal or Human Sources Susanna K. P. Lau, Patrick C. Y. Woo, Amanda P. C. To, Alexson T. K. Lau, and Kwok-yung Yuen Antimicrob. Agents Chemother. August 2004 48: 3141-3146; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Prevalence of Extended-Spectrum ß-Lactamase-Producing Strains among Blood Isolates of Enterobacter spp. Collected in a Tertiary Hospital during an 8-Year Period and Their Antimicrobial Susceptibility Patterns Hyunjoo Pai, Jung Yun Hong, Jeong-Hum Byeon, Yun-Kyung Kim, and Hoan-Jong Lee Antimicrob. Agents Chemother. August 2004 48: 3159-3161; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Telithromycin, Linezolid, and Quinupristin-Dalfopristin against Streptococcus pneumoniae with Macrolide Resistance Due to Ribosomal Mutations David J. Farrell, Ian Morrissey, Sarah Bakker, Sylvie Buckridge, and David Felmingham Antimicrob. Agents Chemother. August 2004 48: 3169-3171; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CMY-13, a Novel Inducible Cephalosporinase Encoded by an Escherichia coli Plasmid V. Miriagou, L. S. Tzouvelekis, L. Villa, E. Lebessi, A. C. Vatopoulos, A. Carattoli, and E. Tzelepi Antimicrob. Agents Chemother. August 2004 48: 3172-3174; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis Maria Rosalia Pasca, Paola Guglierame, Fabio Arcesi, Marco Bellinzoni, Edda De Rossi, and Giovanna Riccardi Antimicrob. Agents Chemother. August 2004 48: 3175-3178; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum-Cephalosporin Resistance in Salmonella enterica Isolates of Animal Origin Jeffrey T. Gray, Laura L. Hungerford, Paula J. Fedorka-Cray, and Marcia L. Headrick Antimicrob. Agents Chemother. August 2004 48: 3179-3181; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Prevalence of the ermB Gene among Erythromycin-Resistant Streptococcus pneumoniae Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin Michael Kresken, Beate Henrichfreise, Simone Bagel, Johannes Brauers, and Bernd Wiedemann Antimicrob. Agents Chemother. August 2004 48: 3193-3195; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of ß-Lactamases and Porins in Resistance to Ertapenem and Other ß-Lactams in Klebsiella pneumoniae George A. Jacoby, Debra M. Mills, and Nancy Chow Antimicrob. Agents Chemother. August 2004 48: 3203-3206; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Unraveling the Mode of Action of the Antimalarial Choline Analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae Rodolphe Roggero, Rachel Zufferey, Mihaela Minca, Eric Richier, Michele Calas, Henri Vial, and Choukri Ben Mamoun Antimicrob. Agents Chemother. August 2004 48: 2816-2824; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling Bernd Hutter, Christoph Schaab, Sebastian Albrecht, Matthias Borgmann, Nina A. Brunner, Christoph Freiberg, Karl Ziegelbauer, Charles O. Rock, Igor Ivanov, and Hannes Loferer Antimicrob. Agents Chemother. August 2004 48: 2838-2844; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic-Inducible Promoter Regulated by the Cell Envelope Stress-Sensing Two-Component System LiaRS of Bacillus subtilis Thorsten Mascher, Sara L. Zimmer, Terry-Ann Smith, and John D. Helmann Antimicrob. Agents Chemother. August 2004 48: 2888-2896; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ribosomal P0 Protein Domain Involved in Selectivity of Antifungal Sordarin Derivatives C. Santos, M. A. Rodríguez-Gabriel, M. Remacha, and J. P. G. Ballesta Antimicrob. Agents Chemother. August 2004 48: 2930-2936; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Positional Hydrophobicity in the Leishmanicidal Activity of Magainin 2 Esther Guerrero, José María Saugar, Katsumi Matsuzaki, and Luis Rivas Antimicrob. Agents Chemother. August 2004 48: 2980-2986; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis Graham S. Timmins, Sharon Master, Frank Rusnak, and Vojo Deretic Antimicrob. Agents Chemother. August 2004 48: 3006-3009; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Possible Mechanism of Miltefosine-Mediated Death of Leishmania donovani Navin K. Verma and Chinmoy S. Dey Antimicrob. Agents Chemother. August 2004 48: 3010-3015; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity Karen M. Grant, Morag H. Dunion, Vanessa Yardley, Alexios-Leandros Skaltsounis, Doris Marko, Gerhard Eisenbrand, Simon L. Croft, Laurent Meijer, and Jeremy C. Mottram Antimicrob. Agents Chemother. August 2004 48: 3033-3042; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Regulation of the Expression of Cell Wall Stress Stimulon Member Gene msrA1 in Methicillin-Susceptible or -Resistant Staphylococcus aureus Roger Pechous, Nagender Ledala, Brian J. Wilkinson, and Radheshyam K. Jayaswal Antimicrob. Agents Chemother. August 2004 48: 3057-3063; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Zidovudine, Lamivudine, and Abacavir Have Different Effects on Resting Cells Infected with Human Immunodeficiency Virus In Vitro Jesús Saavedra-Lozano, Cynthia C. McCoig, Yanying Cao, Ellen S. Vitetta, and Octavio Ramilo Antimicrob. Agents Chemother. August 2004 48: 2825-2830; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Hepatitis C Virus Replication by Arsenic Trioxide Der-Ren Hwang, Yuan-Chin Tsai, Jin-Ching Lee, Kuo-Kuei Huang, Ren-Kuo Lin, Chia-Hua Ho, Jeng-Min Chiou, Ying-Ting Lin, John T. A. Hsu, and Chau-Ting Yeh Antimicrob. Agents Chemother. August 2004 48: 2876-2882; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir Dean Hickman, Sudthida Vasavanonda, George Nequist, Lynn Colletti, Warren M. Kati, Richard Bertz, Ann Hsu, and Dale J. Kempf Antimicrob. Agents Chemother. August 2004 48: 2911-2917; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nucleotide and Amino Acid Polymorphisms at Drug Resistance Sites in Non-B-Subtype Variants of Human Immunodeficiency Virus Type 1 Dan Turner, Bluma Brenner, Daniela Moisi, Mervi Detorio, Raymond Cesaire, Takashi Kurimura, Haruyo Mori, Max Essex, Shlomo Maayan, and Mark A. Wainberg Antimicrob. Agents Chemother. August 2004 48: 2993-2998; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Mutation Patterns in 4,183 Persons Undergoing Genotypic Resistance Testing Soo-Yon Rhee, Tommy Liu, Jaideep Ravela, Matthew J. Gonzales, and Robert W. Shafer Antimicrob. Agents Chemother. August 2004 48: 3122-3126; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Lipid-Peptide Microbicide Inactivates Herpes Simplex Virus Charles E. Isaacs, Jun Hua Jia, and Weimin Xu Antimicrob. Agents Chemother. August 2004 48: 3182-3184; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Activities of ME1036 (CP5609), a Novel Parenteral Carbapenem, against Methicillin-Resistant Staphylococci Mizuyo Kurazono, Takashi Ida, Keiko Yamada, Yoko Hirai, Takahisa Maruyama, Eiki Shitara, and Minoru Yonezawa Antimicrob. Agents Chemother. August 2004 48: 2831-2837; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergy of Daptomycin with Oxacillin and Other ß-Lactams against Methicillin-Resistant Staphylococcus aureus Kenneth H. Rand and Herbert J. Houck Antimicrob. Agents Chemother. August 2004 48: 2871-2875; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Azasterols as Potential Agents for Treatment of Leishmaniasis and Trypanosomiasis Silvia Orenes Lorente, Juliany C. F. Rodrigues, Carmen Jiménez Jiménez, Miranda Joyce-Menekse, Carlos Rodrigues, Simon L. Croft, Vanessa Yardley, Kate de Luca-Fradley, Luis M. Ruiz-Pérez, Julio Urbina, Wanderley de Souza, Dolores González Pacanowska, and Ian H. Gilbert Antimicrob. Agents Chemother. August 2004 48: 2937-2950; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Triclosan and Susceptibilities of Bacteria Isolated from Hands in the Community Allison E. Aiello, Bonnie Marshall, Stuart B. Levy, Phyllis Della-Latta, and Elaine Larson Antimicrob. Agents Chemother. August 2004 48: 2973-2979; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of the Susceptibilities of Burkholderia pseudomallei to Meropenem and Ceftazidime by Conventional and Intracellular Methods T. J. J. Inglis, F. Rodrigues, P. Rigby, R. Norton, and B. J. Currie Antimicrob. Agents Chemother. August 2004 48: 2999-3005; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin Stephanie J. Schrag, Lesley McGee, Cynthia G. Whitney, Bernard Beall, Allen S. Craig, Miriam E. Choate, James H. Jorgensen, Richard R. Facklam, Keith P. Klugman the Active Bacterial Core Surveillance Team Antimicrob. Agents Chemother. August 2004 48: 3016-3023; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Doripenem versus Pseudomonas aeruginosa In Vitro: Activity against Characterized Isolates, Mutants, and Transconjugants and Resistance Selection Potential Shazad Mushtaq, Yigong Ge, and David M. Livermore Antimicrob. Agents Chemother. August 2004 48: 3086-3092; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Ravuconazole and Four Other Antifungal Agents against Fluconazole-Resistant or -Susceptible Clinical Yeast Isolates Manuel Cuenca-Estrella, Alicia Gomez-Lopez, Emilia Mellado, Guillermo Garcia-Effron, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. August 2004 48: 3107-3111; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Omiganan Pentahydrochloride (MBI 226), a Topical 12-Amino-Acid Cationic Peptide: Spectrum of Antimicrobial Activity and Measurements of Bactericidal Activity Helio S. Sader, Kelley A. Fedler, Robert P. Rennie, Shelley Stevens, and Ronald N. Jones Antimicrob. Agents Chemother. August 2004 48: 3112-3118; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Activities of Colicins against Escherichia coli Strains Responsible for Postweaning Diarrhea and Edema Disease in Swine Chad H. Stahl, Todd R. Callaway, Leslie M. Lincoln, Steven M. Lonergan, and Kenneth J. Genovese Antimicrob. Agents Chemother. August 2004 48: 3119-3121; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity and Potency of an Intravenously Injected Antimicrobial Peptide and Its DL Amino Acid Analog in Mice Infected with Bacteria Amir Braunstein, Niv Papo, and Yechiel Shai Antimicrob. Agents Chemother. August 2004 48: 3127-3129; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Killing of Mycobacterium ulcerans by Acidified Nitrite R. Phillips, S. Kuijper, N. Benjamin, M. Wansbrough-Jones, M. Wilks, and A. H. J. Kolk Antimicrob. Agents Chemother. August 2004 48: 3130-3132; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Doripenem (S-4661) against Drug-Resistant Clinical Pathogens Ronald N. Jones, Holly K. Huynh, and Douglas J. Biedenbach Antimicrob. Agents Chemother. August 2004 48: 3136-3140; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of pH on the In Vitro Activities of Amphotericin B, Itraconazole, and Flucytosine against Aspergillus Isolates D. T. A. Te Dorsthorst, J. W. Mouton, C. J. P. van den Beukel, H. A. L. van der Lee, J. F. G. M. Meis, and P. E. Verweij Antimicrob. Agents Chemother. August 2004 48: 3147-3150; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the Newer Quinolones Garenoxacin, Gatifloxacin, and Gemifloxacin against Human Mycoplasmas S. Pereyre, H. Renaudin, C. Bébéar, and C. M. Bébéar Antimicrob. Agents Chemother. August 2004 48: 3165-3168; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Remarkable Increase in Central Japan in 2001-2002 of Neisseria gonorrhoeae Isolates with Decreased Susceptibility to Penicillin, Tetracycline, Oral Cephalosporins, and Fluoroquinolones Masayasu Ito, Mitsuru Yasuda, Shigeaki Yokoi, Shin-ichi Ito, Yoshito Takahashi, Satoshi Ishihara, Shin-ichi Maeda, and Takashi Deguchi Antimicrob. Agents Chemother. August 2004 48: 3185-3187; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antianaerobic Activity of a Novel Fluoroquinolone, WCK 771, Compared to Those of Nine Other Agents Mihaela Peric, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. August 2004 48: 3188-3192; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility of Chlamydia trachomatis to Excipients Commonly Used in Topical Microbicide Formulations M. F. Lampe, L. C. Rohan, M. C. Skinner, and W. E. Stamm Antimicrob. Agents Chemother. August 2004 48: 3200-3202; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Cellular Pharmacokinetics and Pharmacodynamics of the Glycopeptide Antibiotic Oritavancin (LY333328) in a Model of J774 Mouse Macrophages Françoise Van Bambeke, Stéphane Carryn, Cristina Seral, Hugues Chanteux, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, and Paul M. Tulkens Antimicrob. Agents Chemother. August 2004 48: 2853-2860; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Cethromycin (ABT-773) Therapy on Microbiological, Histologic, Immunologic, and Respiratory Indices in a Murine Model of Mycoplasma pneumoniae Lower Respiratory Infection Ana María Ríos, Asunción Mejías, Susana Chávez-Bueno, Mónica Fonseca-Aten, Kathy Katz, Jeanine Hatfield, Ana María Gómez, Hasan S. Jafri, George H. McCracken, Jr., Octavio Ramilo, and Robert Doug Hardy Antimicrob. Agents Chemother. August 2004 48: 2897-2904; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Therapeutic Efficacy of "Nubiotics" against Burn Wound Infection by Pseudomonas aeruginosa Roderic M. K. Dale, Glen Schnell, and Jonathan P. Wong Antimicrob. Agents Chemother. August 2004 48: 2918-2923; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis Ramesh Jayaram, Radha. K. Shandil, Sheshagiri Gaonkar, Parvinder Kaur, B. L. Suresh, B. N. Mahesh, R. Jayashree, Vrinda Nandi, Sowmya Bharath, E. Kantharaj, and V. Balasubramanian Antimicrob. Agents Chemother. August 2004 48: 2951-2957; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Telavancin (TD-6424), a Novel Bactericidal Agent, against Gram-Positive Bacteria Sharath S. Hegde, Noe Reyes, Tania Wiens, Nicole Vanasse, Robert Skinner, Julia McCullough, Koné Kaniga, John Pace, Roger Thomas, Jeng-Pyng Shaw, Glen Obedencio, and J. Kevin Judice Antimicrob. Agents Chemother. August 2004 48: 3043-3050; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Increased Fluconazole Efficacy against Experimental Endocarditis Due to Candida albicans Michael R. Yeaman, Darwin Cheng, Bhavesh Desai, Leon I. Kupferwasser, Yan-Qiong Xiong, Kimberly D. Gank, John E. Edwards, Jr., and Arnold S. Bayer Antimicrob. Agents Chemother. August 2004 48: 3051-3056; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of Activity of Orally Administered Clofazimine against Intracellular Mycobacterium tuberculosis in Whole-Blood Culture Ernestas Janulionis, Carolina Sofer, Ho-Yeon Song, and Robert S. Wallis Antimicrob. Agents Chemother. August 2004 48: 3133-3135; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Granulocyte Colony-Stimulating Factor Combination Therapy on Efficacy of Posaconazole (SCH56592) in an Inhalation Model of Murine Pulmonary Aspergillosis Andriani C. Patera, Frederick Menzel, Craig Jackson, Joan K. Brieland, Judy Halpern, Roberta Hare, Anthony Cacciapuoti, and David Loebenberg Antimicrob. Agents Chemother. August 2004 48: 3154-3158; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Temporin A Soaking in Combination with Intraperitoneal Linezolid Prevents Vascular Graft Infection in a Subcutaneous Rat Pouch Model of Infection with Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Giuseppina D'Amato, Wojciech Kamysz, Federico Mocchegiani, Valerio Sisti, Carmela Silvestri, Jerzy Lukasiak, Marco Rocchi, Vittorio Saba, and Giorgio Scalise Antimicrob. Agents Chemother. August 2004 48: 3162-3164; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Disposition of Artesunate and Dihydroartemisinin after Administration of Artesunate Suppositories in Children from Papua New Guinea with Uncomplicated Malaria Harin A. Karunajeewa, Kenneth F. Ilett, Kitiya Dufall, Adedayo Kemiki, Moses Bockarie, Michael P. Alpers, P. Hugh Barrett, Paolo Vicini, and Timothy M. E. Davis Antimicrob. Agents Chemother. August 2004 48: 2966-2972; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice Philip Lake, Jeffrey DeLeo, Franklin Cerasoli, Lennart Logdberg, Marla Weetall, and Dean Handley Antimicrob. Agents Chemother. August 2004 48: 2987-2992; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH) Xin He, Anne McElwee Reeve, Umesh R. Desai, Glen E. Kellogg, and Kevin A. Reynolds Antimicrob. Agents Chemother. August 2004 48: 3093-3102; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda Sabrina Krief, Marie-Thérèse Martin, Philippe Grellier, John Kasenene, and Thierry Sévenet Antimicrob. Agents Chemother. August 2004 48: 3196-3199; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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nimE Gene in a Metronidazole-Susceptible Veillonella sp. Strain H. Marchandin, H. Jean-Pierre, J. Campos, L. Dubreuil, C. Teyssier, and E. Jumas-Bilak Antimicrob. Agents Chemother. August 2004 48: 3207-3208; [Full Text] [PDF] [Reprints and Permissions]

Spectrum of pncA Mutations in Multidrug-Resistant Mycobacterium tuberculosis Isolates Obtained in Latvia Tatjana Tracevska, Inta Jansone, Viesturs Baumanis, Anda Nodieva, Olgerts Marga, and Girts Skenders Antimicrob. Agents Chemother. August 2004 48: 3209-3210; [Full Text] [PDF] [Reprints and Permissions]

Challenges in Designing Animal Studies To Detect Antagonism of Polyene Activity Russell E. Lewis, Dimitrios P. Kantoyiannis, L. K. Najvar, J. R. Graybill, and A. F. Cacciapuoti Antimicrob. Agents Chemother. August 2004 48: 3211-3212; [Full Text] [PDF] [Reprints and Permissions]

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Author's Correction:

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Killing by Ampicillin and Ofloxacin Induces Overlapping Changes in Escherichia coli Transcription Profile Niilo Kaldalu, Rui Mei, and Kim Lewis Antimicrob. Agents Chemother. August 2004 48: 3213 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Field Evaluation of a Novel Colorimetric Method—Double-Site Enzyme-Linked Lactate Dehydrogenase Immunodetection Assay—To Determine Drug Susceptibilities of Plasmodium falciparum Clinical Isolates from Northwestern Thailand Alan Brockman, Sittaporn Singlam, Lucy Phiaphun, Sornchai Looareesuwan, Nicholas J. White, and François Nosten Antimicrob. Agents Chemother. August 2004 48: 3214 [Full Text] [PDF] [Reprints and Permissions]

Sulfadoxine-Pyrimethamine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi Karen Hayton, Lisa C. Ranford-Cartwright, and David Walliker Antimicrob. Agents Chemother. August 2004 48: 3215 [Full Text] [PDF] [Reprints and Permissions]

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