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Minireviews:

William J. Steinbach, John R. Perfect, Wiley A. Schell, Thomas J. Walsh, and Daniel K. Benjamin, Jr.

In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection
Antimicrob. Agents Chemother. 2004 48: 3217-3225. [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Chantal Csajka, Catia Marzolini, Karin Fattinger, Laurent A. Décosterd, Amalio Telenti, Jérôme Biollaz, and Thierry Buclin

Population Pharmacokinetics of Indinavir in Patients Infected with Human Immunodeficiency Virus
Antimicrob. Agents Chemother. 2004 48: 3226-3232. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Daniel P. Rossignol, Kishor M. Wasan, Eugene Choo, Edwin Yau, Nancy Wong, Jeffrey Rose, Jeffrey Moran, and Melvyn Lynn

Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers
Antimicrob. Agents Chemother. 2004 48: 3233-3240. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David E. Nix, Kathryn R. Matthias, and Emily C. Ferguson

Effect of Ertapenem Protein Binding on Killing of Bacteria
Antimicrob. Agents Chemother. 2004 48: 3419-3424. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John E. Conte, Jr., Jeffrey A. Golden, Juliana Kipps, and Elisabeth Zurlinden

Steady-State Plasma and Intrapulmonary Pharmacokinetics and Pharmacodynamics of Cethromycin
Antimicrob. Agents Chemother. 2004 48: 3508-3515. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Philip Krieter, Brian Flannery, Timothy Musick, Mark Gohdes, Monika Martinho, and Rachel Courtney

Disposition of Posaconazole following Single-Dose Oral Administration in Healthy Subjects
Antimicrob. Agents Chemother. 2004 48: 3543-3551. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Mei-Lin Go, Mei Liu, Prapon Wilairat, Philip J. Rosenthal, Kevin J. Saliba, and Kiaran Kirk

Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes
Antimicrob. Agents Chemother. 2004 48: 3241-3245. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Linda Tomasinsig, Marco Scocchi, Romina Mettulio, and Margherita Zanetti

Genome-Wide Transcriptional Profiling of the Escherichia coli Response to a Proline-Rich Antimicrobial Peptide
Antimicrob. Agents Chemother. 2004 48: 3260-3267. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hugo Vanden Bossche, Jannie Ausma, Hilde Bohets, Karen Vermuyten, Gustaaf Willemsens, Patrick Marichal, Lieven Meerpoel, Frank Odds, and Marcel Borgers

The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis
Antimicrob. Agents Chemother. 2004 48: 3272-3278. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mohammed A. Al-Fattani and L. Julia Douglas

Penetration of Candida Biofilms by Antifungal Agents
Antimicrob. Agents Chemother. 2004 48: 3291-3297. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Isabelle Marchand, Laurence Damier-Piolle, Patrice Courvalin, and Thierry Lambert

Expression of the RND-Type Efflux Pump AdeABC in Acinetobacter baumannii Is Regulated by the AdeRS Two-Component System
Antimicrob. Agents Chemother. 2004 48: 3298-3304. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Maria Fluckinger, Hubertus Haas, Petra Merschak, Ben J. Glasgow, and Bernhard Redl

Human Tear Lipocalin Exhibits Antimicrobial Activity by Scavenging Microbial Siderophores
Antimicrob. Agents Chemother. 2004 48: 3367-3372. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

K. M. Rogers, C. A. Pierson, N. T. Culbertson, C. Mo, A. M. Sturm, J. Eckstein, R. Barbuch, N. D. Lees, and M. Bard

Disruption of the Candida albicans CYB5 Gene Results in Increased Azole Sensitivity
Antimicrob. Agents Chemother. 2004 48: 3425-3435. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yoshifumi Imamura, Katsunori Yanagihara, Yohei Mizuta, Masafumi Seki, Hideaki Ohno, Yasuhito Higashiyama, Yoshitsugu Miyazaki, Kazuhiro Tsukamoto, Yoichi Hirakata, Kazunori Tomono, Jun-ichi Kadota, and Shigeru Kohno

Azithromycin Inhibits MUC5AC Production Induced by the Pseudomonas aeruginosa Autoinducer N-(3-Oxododecanoyl) Homoserine Lactone in NCI-H292 Cells
Antimicrob. Agents Chemother. 2004 48: 3457-3461. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

J. A. Sánchez-Brunete, M. A. Dea, S. Rama, F. Bolás, J. M. Alunda, R. Raposo, M. T. Méndez, S. Torrado-Santiago, and J. J. Torrado

Treatment of Experimental Visceral Leishmaniasis with Amphotericin B in Stable Albumin Microspheres
Antimicrob. Agents Chemother. 2004 48: 3246-3252. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Francesco Barchiesi, Elisabetta Spreghini, Anna M. Schimizzi, Monia Maracci, Daniele Giannini, Flavia Carle, and Giorgio Scalise

Posaconazole and Amphotericin B Combination Therapy against Cryptococcus neoformans Infection
Antimicrob. Agents Chemother. 2004 48: 3312-3316. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Darrin J. Bast, M. Yue, X. Chen, D. Bell, L. Dresser, R. Saskin, L. A. Mandell, D. E. Low, and Joyce C. S. de Azavedo

Novel Murine Model of Pneumococcal Pneumonia: Use of Temperature as a Measure of Disease Severity To Compare the Efficacies of Moxifloxacin and Levofloxacin
Antimicrob. Agents Chemother. 2004 48: 3343-3348. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. Szynol, J. J. de Soet, E. Sieben-van Tuyl, J. W. Bos, and L. G. Frenken

Bactericidal Effects of a Fusion Protein of Llama Heavy-Chain Antibodies Coupled to Glucose Oxidase on Oral Bacteria
Antimicrob. Agents Chemother. 2004 48: 3390-3395. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Emilia Ghelardi, Arianna Tavanti, Paola Davini, Francesco Celandroni, Sara Salvetti, Eva Parisio, Enrico Boldrini, Sonia Senesi, and Mario Campa

A Mucoadhesive Polymer Extracted from Tamarind Seed Improves the Intraocular Penetration and Efficacy of Rufloxacin in Topical Treatment of Experimental Bacterial Keratitis
Antimicrob. Agents Chemother. 2004 48: 3396-3401. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Samir Jawhara and Serge Mordon

In Vivo Imaging of Bioluminescent Escherichia coli in a Cutaneous Wound Infection Model for Evaluation of an Antibiotic Therapy
Antimicrob. Agents Chemother. 2004 48: 3436-3441. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Eva Westman, Susanne Lundin, Ann Hermansson, and Åsa Melhus

ß-Lactamase-Producing Nontypeable Haemophilus influenzae Fails To Protect Streptococcus pneumoniae from Amoxicillin during Experimental Acute Otitis Media
Antimicrob. Agents Chemother. 2004 48: 3536-3542. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Luiz E. Bermudez, Peter Kolonoski, Lianne E. Seitz, Mary Petrofsky, Robert Reynolds, Martin Wu, and Lowell S. Young

SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease
Antimicrob. Agents Chemother. 2004 48: 3556-3558. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Swati Pal, Rajesh Ravindran, and Nahid Ali

Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and Chronic Leishmania donovani Infection in BALB/c Mice
Antimicrob. Agents Chemother. 2004 48: 3591-3593. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rama Falk, Jacob Grunwald, Amnon Hoffman, Abraham J. Domb, and Itzhack Polacheck

Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis
Antimicrob. Agents Chemother. 2004 48: 3606-3609. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Stefano Menzo, Antonella Castagna, Alessia Monachetti, Hamid Hasson, Anna Danise, Elisabetta Carini, Patrizia Bagnarelli, Adriano Lazzarin, and Massimo Clementi

Genotype and Phenotype Patterns of Human Immunodeficiency Virus Type 1 Resistance to Enfuvirtide during Long-Term Treatment
Antimicrob. Agents Chemother. 2004 48: 3253-3259. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Eleanor Barnes, Mariolina Salio, Vincenzo Cerundolo, Joanne Medlin, Shona Murphy, Geoffrey Dusheiko, and Paul Klenerman

Impact of Alpha Interferon and Ribavirin on the Function of Maturing Dendritic Cells
Antimicrob. Agents Chemother. 2004 48: 3382-3389. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael J. Hofman, Joanne Higgins, Timothy B. Matthews, Niels C. Pedersen, Chalet Tan, Raymond F. Schinazi, and Thomas W. North

Efavirenz Therapy in Rhesus Macaques Infected with a Chimera of Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2004 48: 3483-3490. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

D. J. Tenney, S. M. Levine, R. E. Rose, A. W. Walsh, S. P. Weinheimer, L. Discotto, M. Plym, K. Pokornowski, C. F. Yu, P. Angus, A. Ayres, A. Bartholomeusz, W. Sievert, G. Thompson, N. Warner, S. Locarnini, and R. J. Colonno

Clinical Emergence of Entecavir-Resistant Hepatitis B Virus Requires Additional Substitutions in Virus Already Resistant to Lamivudine
Antimicrob. Agents Chemother. 2004 48: 3498-3507. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Earl R. Kern, Deborah J. Collins, W. Brad Wan, James R. Beadle, Karl Y. Hostetler, and Debra C. Quenelle

Oral Treatment of Murine Cytomegalovirus Infections with Ether Lipid Esters of Cidofovir
Antimicrob. Agents Chemother. 2004 48: 3516-3522. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Shin-Ru Shih, Mun-Chung Tsai, Sung-Nien Tseng, Kuo-Fang Won, Kak-Shan Shia, Wen-Tai Li, Jyh-Haur Chern, Guang-Wu Chen, Chung-Chi Lee, Yen-Chun Lee, Kuan-Chang Peng, and Yu-Sheng Chao

Mutation in Enterovirus 71 Capsid Protein VP1 Confers Resistance to the Inhibitory Effects of Pyridyl Imidazolidinone
Antimicrob. Agents Chemother. 2004 48: 3523-3529. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Luis M. F. Gonzalez, Rodrigo M. Brindeiro, Renato S. Aguiar, Helena S. Pereira, Celina M. Abreu, Marcelo A. Soares, and Amilcar Tanuri

Impact of Nelfinavir Resistance Mutations on In Vitro Phenotype, Fitness, and Replication Capacity of Human Immunodeficiency Virus Type 1 with Subtype B and C Proteases
Antimicrob. Agents Chemother. 2004 48: 3552-3555. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anne Boulestin, Nassim Kamar, Florence Legrand-Abravanel, Karine Sandres-Saune, Laurent Alric, Jean-Pierre Vinel, Lionel Rostaing, and Jacques Izopet

Convenient Biological Assay for Polyethylene Glycol-Interferons in Patients with Hepatitis C
Antimicrob. Agents Chemother. 2004 48: 3610-3612. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

M. Ernst Schweingruber

The Melaminophenyl Arsenicals Melarsoprol and Melarsen Oxide Interfere with Thiamine Metabolism in the Fission Yeast Schizosaccharomyces pombe
Antimicrob. Agents Chemother. 2004 48: 3268-3271. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Daniel Aubert, Delphine Girlich, Thierry Naas, Shanta Nagarajan, and Patrice Nordmann

Functional and Structural Characterization of the Genetic Environment of an Extended-Spectrum ß-Lactamase bla_VEB Gene from a Pseudomonas aeruginosa Isolate Obtained in India
Antimicrob. Agents Chemother. 2004 48: 3284-3290. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lars Hestbjerg Hansen, Elsebetta Johannesen, Mette Burmølle, Anders Hay Sørensen, and Søren J. Sørensen

Plasmid-Encoded Multidrug Efflux Pump Conferring Resistance to Olaquindox in Escherichia coli
Antimicrob. Agents Chemother. 2004 48: 3332-3337. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Carolina Mateus, Sidney A. Crow, Jr., and Donald G. Ahearn

Adherence of Candida albicans to Silicone Induces Immediate Enhanced Tolerance to Fluconazole
Antimicrob. Agents Chemother. 2004 48: 3358-3366. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rosilene Fressatti Cardoso, Robert C. Cooksey, Glenn P. Morlock, Patricia Barco, Leticia Cecon, Francisco Forestiero, Clarice Q. F. Leite, Daisy N. Sato, Maria de Lourdes Shikama, Elsa M. Mamizuka, Rosario D. C. Hirata, and Mario H. Hirata

Screening and Characterization of Mutations in Isoniazid-Resistant Mycobacterium tuberculosis Isolates Obtained in Brazil
Antimicrob. Agents Chemother. 2004 48: 3373-3381. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Gerhard F. Weldhagen

Sequence-Selective Recognition of Extended-Spectrum ß-Lactamase GES-2 by a Competitive, Peptide Nucleic Acid-Based Multiplex PCR Assay
Antimicrob. Agents Chemother. 2004 48: 3402-3406. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Julie S. Philalay, Christine O. Palermo, Kirsten A. Hauge, Tige R. Rustad, and Gerard A. Cangelosi

Genes Required for Intrinsic Multidrug Resistance in Mycobacterium avium
Antimicrob. Agents Chemother. 2004 48: 3412-3418. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Amera Gibreel, Dobryan M. Tracz, Lisa Nonaka, Trinh M. Ngo, Sean R. Connell, and Diane E. Taylor

Incidence of Antibiotic Resistance in Campylobacter jejuni Isolated in Alberta, Canada, from 1999 to 2002, with Special Reference to tet(O)-Mediated Tetracycline Resistance
Antimicrob. Agents Chemother. 2004 48: 3442-3450. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

K. K. Ojo, C. Ulep, N. Van Kirk, H. Luis, M. Bernardo, J. Leitao, and M. C. Roberts

The mef(A) Gene Predominates among Seven Macrolide Resistance Genes Identified in Gram-Negative Strains Representing 13 Genera, Isolated from Healthy Portuguese Children
Antimicrob. Agents Chemother. 2004 48: 3451-3456. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paula Cerdá Zolezzi, Leticia Millán Laplana, Carmen Rubio Calvo, Pilar Goñi Cepero, Melisa Canales Erazo, and Rafael Gómez-Lus

Molecular Basis of Resistance to Macrolides and Other Antibiotics in Commensal Viridans Group Streptococci and Gemella spp. and Transfer of Resistance Genes to Streptococcus pneumoniae
Antimicrob. Agents Chemother. 2004 48: 3462-3467. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

H. Sahly, H. Aucken, V. J. Benedí, C. Forestier, V. Fussing, D. S. Hansen, I. Ofek, R. Podschun, D. Sirot, J. M. Tomás, D. Sandvang, and U. Ullmann

Increased Serum Resistance in Klebsiella pneumoniae Strains Producing Extended-Spectrum ß-Lactamases
Antimicrob. Agents Chemother. 2004 48: 3477-3482. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marcia A. S. Graminha, Eleusa M. F. Rocha, Rolf A. Prade, and Nilce M. Martinez-Rossi

Terbinafine Resistance Mediated by Salicylate 1-Monooxygenase in Aspergillus nidulans
Antimicrob. Agents Chemother. 2004 48: 3530-3535. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christoph Hauser, Suzanne Aebi, and Kathrin Mühlemann

An Internationally Spread Clone of Streptococcus pneumoniae Evolves from Low-Level to Higher-Level Penicillin Resistance by Uptake of Penicillin-Binding Protein Gene Fragments from Nonencapsulated Pneumococci
Antimicrob. Agents Chemother. 2004 48: 3563-3566. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rasel Khan, Shamsun Nahar, Jinath Sultana, Mian Mashhud Ahmad, and Motiur Rahman

T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh
Antimicrob. Agents Chemother. 2004 48: 3567-3569. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Xinying Li, Noriel Mariano, James J. Rahal, Carl M. Urban, and Karl Drlica

Quinolone-Resistant Haemophilus influenzae in a Long-Term-Care Facility: Nucleotide Sequence Characterization of Alterations in the Genes Encoding DNA Gyrase and DNA Topoisomerase IV
Antimicrob. Agents Chemother. 2004 48: 3570-3572. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olivia Gutiérrez, Carlos Juan, José L. Pérez, and Antonio Oliver

Lack of Association between Hypermutation and Antibiotic Resistance Development in Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients
Antimicrob. Agents Chemother. 2004 48: 3573-3575. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Balázs Libisch, Mária Gacs, Károly Csiszár, Mónika Muzslay, László Rókusz, and Miklós Füzi

Isolation of an Integron-Borne bla_VIM-4 Type Metallo-ß-Lactamase Gene from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate in Hungary
Antimicrob. Agents Chemother. 2004 48: 3576-3578. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Bibiana Caporale, Nicola Franceschini, Mariagrazia Perilli, Bernardetta Segatore, Gian Maria Rossolini, and Gianfranco Amicosante

Biochemical Characterization of Laboratory Mutants of Extended-Spectrum ß-Lactamase TEM-60
Antimicrob. Agents Chemother. 2004 48: 3579-3582. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Issam I. Raad, Hend A. Hanna, Ray Y. Hachem, Tanya Dvorak, Rebecca B. Arbuckle, Gassan Chaiban, and Louis B. Rice

Clinical-Use-Associated Decrease in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Linezolid: a Comparison with Quinupristin-Dalfopristin
Antimicrob. Agents Chemother. 2004 48: 3583-3585. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paul F. Riska, Andrei Kutlin, Patrick Ajiboye, Arnold Cua, Patricia M. Roblin, and Margaret R. Hammerschlag

Genetic and Culture-Based Approaches for Detecting Macrolide Resistance in Chlamydia pneumoniae
Antimicrob. Agents Chemother. 2004 48: 3586-3590. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alexander J. O'Neill, Anders R. Larsen, Anne S. Henriksen, and Ian Chopra

A Fusidic Acid-Resistant Epidemic Strain of Staphylococcus aureus Carries the fusB Determinant, whereas fusA Mutations Are Prevalent in Other Resistant Isolates
Antimicrob. Agents Chemother. 2004 48: 3594-3597. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Abigael Mbaisi, Pamela Liyala, Fredrick Eyase, Rachel Achilla, Hosea Akala, Julia Wangui, Josphat Mwangi, Finnley Osuna, Uzma Alam, Bonnie L. Smoak, Jon M. Davis, Dennis E. Kyle, Rodney L. Coldren, Carl Mason, and Norman C. Waters

Drug Susceptibility and Genetic Evaluation of Plasmodium falciparum Isolates Obtained in Four Distinct Geographical Regions of Kenya
Antimicrob. Agents Chemother. 2004 48: 3598-3601. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Carla Novais, Teresa M. Coque, João Carlos Sousa, Fernando Baquero, and Luisa Peixe

Local Genetic Patterns within a Vancomycin-Resistant Enterococcus faecalis Clone Isolated in Three Hospitals in Portugal
Antimicrob. Agents Chemother. 2004 48: 3613-3617. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Renaud Chollet, Jacqueline Chevalier, André Bryskier, and Jean-Marie Pagès

The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux in Enterobacter aerogenes and Escherichia coli
Antimicrob. Agents Chemother. 2004 48: 3621-3624. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olivier Denis, Ariane Deplano, Claire Nonhoff, Raf De Ryck, Ricardo de Mendonça, Sylvianne Rottiers, Raymond Vanhoof, and Marc J. Struelens

National Surveillance of Methicillin-Resistant Staphylococcus aureus in Belgian Hospitals Indicates Rapid Diversification of Epidemic Clones
Antimicrob. Agents Chemother. 2004 48: 3625-3629. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Aya Yekutiel, Itamar Shalit, Yona Shadkchan, and Nir Osherov

In Vitro Activity of Caspofungin Combined with Sulfamethoxazole against Clinical Isolates of Aspergillus spp.
Antimicrob. Agents Chemother. 2004 48: 3279-3283. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jeff Powis, Allison McGeer, Karen Green, Otto Vanderkooi, Karl Weiss, George Zhanel, Tony Mazzulli, Magdalena Kuhn, Deirdre Church, Ross Davidson, Kevin Forward, Daryl Hoban, Andrew Simor, and Donald E. Low

In Vitro Antimicrobial Susceptibilities of Streptococcus pneumoniae Clinical Isolates Obtained in Canada in 2002
Antimicrob. Agents Chemother. 2004 48: 3305-3311. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Francesco Barchiesi, Elisabetta Spreghini, Monia Maracci, Annette W. Fothergill, Isabella Baldassarri, Michael G. Rinaldi, and Giorgio Scalise

In Vitro Activities of Voriconazole in Combination with Three Other Antifungal Agents against Candida glabrata
Antimicrob. Agents Chemother. 2004 48: 3317-3322. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael R. Jacobs, Saralee Bajaksouzian, Anne Windau, Peter C. Appelbaum, Mahesh V. Patel, Shrikant V. Gupte, Sachin S. Bhagwat, Noel J. De Souza, and Habil F. Khorakiwala

In Vitro Activity of the New Quinolone WCK 771 against Staphylococci
Antimicrob. Agents Chemother. 2004 48: 3338-3342. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David A. Stevens, Marife Espiritu, and Rachana Parmar

Paradoxical Effect of Caspofungin: Reduced Activity against Candida albicans at High Drug Concentrations
Antimicrob. Agents Chemother. 2004 48: 3407-3411. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mathias W. R. Pletz, Lesley McGee, James Jorgensen, Bernard Beall, Richard R. Facklam, Cynthia G. Whitney, and Keith P. Klugman

Levofloxacin-Resistant Invasive Streptococcus pneumoniae in the United States: Evidence for Clonal Spread and the Impact of Conjugate Pneumococcal Vaccine
Antimicrob. Agents Chemother. 2004 48: 3491-3497. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Edouard Bingen, Philippe Bidet, Liliana Mihaila-Amrouche, Catherine Doit, Samuel Forcet, Naïma Brahimi, Anne Bouvet, and Robert Cohen

Emergence of Macrolide-Resistant Streptococcus pyogenes Strains in French Children
Antimicrob. Agents Chemother. 2004 48: 3559-3562. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Joel N. Maslow, Ebbing Lautenbach, Thomas Glaze, Warren Bilker, and James R. Johnson

Colonization with Extraintestinal Pathogenic Escherichia coli among Nursing Home Residents and Its Relationship to Fluoroquinolone Resistance
Antimicrob. Agents Chemother. 2004 48: 3618-3620. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

H. J. Smith, A. M. Noreddin, C. G. Siemens, K. N. Schurek, J. Greisman, C. J. Hoban, D. J. Hoban, and G. G. Zhanel

Designing Fluoroquinolone Breakpoints for Streptococcus pneumoniae by Using Genetics instead of Pharmacokinetics-Pharmacodynamics
Antimicrob. Agents Chemother. 2004 48: 3630-3635. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jean-Winoc Decousser, Patrick Pina, Florent Viguier, Franc Picot, Patrice Courvalin, and Pierre Allouch

Invasive Streptococcus pneumoniae in France: Antimicrobial Resistance, Serotype, and Molecular Epidemiology Findings from a Monthly National Study in 2000 to 2002
Antimicrob. Agents Chemother. 2004 48: 3636-3639. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

T. M. File, Jr., H. Lode, H. Kurz, R. Kozak, H. Xie, and E. Berkowitz

Double-Blind, Randomized Study of the Efficacy and Safety of Oral Pharmacokinetically Enhanced Amoxicillin-Clavulanate (2,000/125 Milligrams) versus Those of Amoxicillin-Clavulanate (875/125 Milligrams), Both Given Twice Daily for 7 Days, in Treatment of Bacterial Community-Acquired Pneumonia in Adults
Antimicrob. Agents Chemother. 2004 48: 3323-3331. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chemistry; Biosynthesis:

V. Frecer, B. Ho, and J. L. Ding

De Novo Design of Potent Antimicrobial Peptides
Antimicrob. Agents Chemother. 2004 48: 3349-3357. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Miyuki Otsuka, Koji Ichinose, Isao Fujii, and Yutaka Ebizuka

Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in "Streptomyces carzinostaticus"
Antimicrob. Agents Chemother. 2004 48: 3468-3476. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Andrea L. Crowell, Chad E. Stephens, Arvind Kumar, David W. Boykin, and W. Evan Secor

Activities of Dicationic Compounds against Trichomonas vaginalis
Antimicrob. Agents Chemother. 2004 48: 3602-3605. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Susan Shin-Jung Lee, Yung-Ching Liu, Yao-Shen Chen, Hung-Chin Tsai, Shue-Ren Wann, Chih-Hsiang Kao, Feng-Yee Chang, and L. K. Siu

Insufficient Evidence that Extended-Spectrum Cephalosporins Effectively Prevent Metastatic Infections Related to Klebsiella pneumoniae-Caused Liver Abscess
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