AAC -- Table of Contents (September 1 2004, 48 [9])

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Contents: September 2004, Volume 48, Issue 9

       Minireviews

       Pharmacology

       Mechanisms of Action

       Experimental Therapeutics

       Antiviral Agents

       Mechanisms of Resistance

       Susceptibility

       Clinical Therapeutics

       Chemistry; Biosynthesis

       Letters

Other Issues

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Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Minireviews:

In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection
William J. Steinbach, John R. Perfect, Wiley A. Schell, Thomas J. Walsh, and Daniel K. Benjamin, Jr.
Antimicrob. Agents Chemother. September 2004 48: 3217-3225;
[Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Population Pharmacokinetics of Indinavir in Patients Infected with Human Immunodeficiency Virus
Chantal Csajka, Catia Marzolini, Karin Fattinger, Laurent A. Décosterd, Amalio Telenti, Jérôme Biollaz, and Thierry Buclin
Antimicrob. Agents Chemother. September 2004 48: 3226-3232;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers
Daniel P. Rossignol, Kishor M. Wasan, Eugene Choo, Edwin Yau, Nancy Wong, Jeffrey Rose, Jeffrey Moran, and Melvyn Lynn
Antimicrob. Agents Chemother. September 2004 48: 3233-3240;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Ertapenem Protein Binding on Killing of Bacteria
David E. Nix, Kathryn R. Matthias, and Emily C. Ferguson
Antimicrob. Agents Chemother. September 2004 48: 3419-3424;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Steady-State Plasma and Intrapulmonary Pharmacokinetics and Pharmacodynamics of Cethromycin
John E. Conte, Jr., Jeffrey A. Golden, Juliana Kipps, and Elisabeth Zurlinden
Antimicrob. Agents Chemother. September 2004 48: 3508-3515;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Disposition of Posaconazole following Single-Dose Oral Administration in Healthy Subjects
Philip Krieter, Brian Flannery, Timothy Musick, Mark Gohdes, Monika Martinho, and Rachel Courtney
Antimicrob. Agents Chemother. September 2004 48: 3543-3551;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes
Mei-Lin Go, Mei Liu, Prapon Wilairat, Philip J. Rosenthal, Kevin J. Saliba, and Kiaran Kirk
Antimicrob. Agents Chemother. September 2004 48: 3241-3245;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genome-Wide Transcriptional Profiling of the Escherichia coli Response to a Proline-Rich Antimicrobial Peptide
Linda Tomasinsig, Marco Scocchi, Romina Mettulio, and Margherita Zanetti
Antimicrob. Agents Chemother. September 2004 48: 3260-3267;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis
Hugo Vanden Bossche, Jannie Ausma, Hilde Bohets, Karen Vermuyten, Gustaaf Willemsens, Patrick Marichal, Lieven Meerpoel, Frank Odds, and Marcel Borgers
Antimicrob. Agents Chemother. September 2004 48: 3272-3278;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penetration of Candida Biofilms by Antifungal Agents
Mohammed A. Al-Fattani and L. Julia Douglas
Antimicrob. Agents Chemother. September 2004 48: 3291-3297;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Expression of the RND-Type Efflux Pump AdeABC in Acinetobacter baumannii Is Regulated by the AdeRS Two-Component System
Isabelle Marchand, Laurence Damier-Piolle, Patrice Courvalin, and Thierry Lambert
Antimicrob. Agents Chemother. September 2004 48: 3298-3304;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Tear Lipocalin Exhibits Antimicrobial Activity by Scavenging Microbial Siderophores
Maria Fluckinger, Hubertus Haas, Petra Merschak, Ben J. Glasgow, and Bernhard Redl
Antimicrob. Agents Chemother. September 2004 48: 3367-3372;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Disruption of the Candida albicans CYB5 Gene Results in Increased Azole Sensitivity
K. M. Rogers, C. A. Pierson, N. T. Culbertson, C. Mo, A. M. Sturm, J. Eckstein, R. Barbuch, N. D. Lees, and M. Bard
Antimicrob. Agents Chemother. September 2004 48: 3425-3435;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Azithromycin Inhibits MUC5AC Production Induced by the Pseudomonas aeruginosa Autoinducer N-(3-Oxododecanoyl) Homoserine Lactone in NCI-H292 Cells
Yoshifumi Imamura, Katsunori Yanagihara, Yohei Mizuta, Masafumi Seki, Hideaki Ohno, Yasuhito Higashiyama, Yoshitsugu Miyazaki, Kazuhiro Tsukamoto, Yoichi Hirakata, Kazunori Tomono, Jun-ichi Kadota, and Shigeru Kohno
Antimicrob. Agents Chemother. September 2004 48: 3457-3461;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Treatment of Experimental Visceral Leishmaniasis with Amphotericin B in Stable Albumin Microspheres
J. A. Sánchez-Brunete, M. A. Dea, S. Rama, F. Bolás, J. M. Alunda, R. Raposo, M. T. Méndez, S. Torrado-Santiago, and J. J. Torrado
Antimicrob. Agents Chemother. September 2004 48: 3246-3252;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Posaconazole and Amphotericin B Combination Therapy against Cryptococcus neoformans Infection
Francesco Barchiesi, Elisabetta Spreghini, Anna M. Schimizzi, Monia Maracci, Daniele Giannini, Flavia Carle, and Giorgio Scalise
Antimicrob. Agents Chemother. September 2004 48: 3312-3316;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Murine Model of Pneumococcal Pneumonia: Use of Temperature as a Measure of Disease Severity To Compare the Efficacies of Moxifloxacin and Levofloxacin
Darrin J. Bast, M. Yue, X. Chen, D. Bell, L. Dresser, R. Saskin, L. A. Mandell, D. E. Low, and Joyce C. S. de Azavedo
Antimicrob. Agents Chemother. September 2004 48: 3343-3348;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Effects of a Fusion Protein of Llama Heavy-Chain Antibodies Coupled to Glucose Oxidase on Oral Bacteria
A. Szynol, J. J. de Soet, E. Sieben-van Tuyl, J. W. Bos, and L. G. Frenken
Antimicrob. Agents Chemother. September 2004 48: 3390-3395;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Mucoadhesive Polymer Extracted from Tamarind Seed Improves the Intraocular Penetration and Efficacy of Rufloxacin in Topical Treatment of Experimental Bacterial Keratitis
Emilia Ghelardi, Arianna Tavanti, Paola Davini, Francesco Celandroni, Sara Salvetti, Eva Parisio, Enrico Boldrini, Sonia Senesi, and Mario Campa
Antimicrob. Agents Chemother. September 2004 48: 3396-3401;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Imaging of Bioluminescent Escherichia coli in a Cutaneous Wound Infection Model for Evaluation of an Antibiotic Therapy
Samir Jawhara and Serge Mordon
Antimicrob. Agents Chemother. September 2004 48: 3436-3441;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

ß-Lactamase-Producing Nontypeable Haemophilus influenzae Fails To Protect Streptococcus pneumoniae from Amoxicillin during Experimental Acute Otitis Media
Eva Westman, Susanne Lundin, Ann Hermansson, and Åsa Melhus
Antimicrob. Agents Chemother. September 2004 48: 3536-3542;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease
Luiz E. Bermudez, Peter Kolonoski, Lianne E. Seitz, Mary Petrofsky, Robert Reynolds, Martin Wu, and Lowell S. Young
Antimicrob. Agents Chemother. September 2004 48: 3556-3558;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and Chronic Leishmania donovani Infection in BALB/c Mice
Swati Pal, Rajesh Ravindran, and Nahid Ali
Antimicrob. Agents Chemother. September 2004 48: 3591-3593;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis
Rama Falk, Jacob Grunwald, Amnon Hoffman, Abraham J. Domb, and Itzhack Polacheck
Antimicrob. Agents Chemother. September 2004 48: 3606-3609;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Genotype and Phenotype Patterns of Human Immunodeficiency Virus Type 1 Resistance to Enfuvirtide during Long-Term Treatment
Stefano Menzo, Antonella Castagna, Alessia Monachetti, Hamid Hasson, Anna Danise, Elisabetta Carini, Patrizia Bagnarelli, Adriano Lazzarin, and Massimo Clementi
Antimicrob. Agents Chemother. September 2004 48: 3253-3259;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Alpha Interferon and Ribavirin on the Function of Maturing Dendritic Cells
Eleanor Barnes, Mariolina Salio, Vincenzo Cerundolo, Joanne Medlin, Shona Murphy, Geoffrey Dusheiko, and Paul Klenerman
Antimicrob. Agents Chemother. September 2004 48: 3382-3389;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efavirenz Therapy in Rhesus Macaques Infected with a Chimera of Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1
Michael J. Hofman, Joanne Higgins, Timothy B. Matthews, Niels C. Pedersen, Chalet Tan, Raymond F. Schinazi, and Thomas W. North
Antimicrob. Agents Chemother. September 2004 48: 3483-3490;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Emergence of Entecavir-Resistant Hepatitis B Virus Requires Additional Substitutions in Virus Already Resistant to Lamivudine
D. J. Tenney, S. M. Levine, R. E. Rose, A. W. Walsh, S. P. Weinheimer, L. Discotto, M. Plym, K. Pokornowski, C. F. Yu, P. Angus, A. Ayres, A. Bartholomeusz, W. Sievert, G. Thompson, N. Warner, S. Locarnini, and R. J. Colonno
Antimicrob. Agents Chemother. September 2004 48: 3498-3507;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral Treatment of Murine Cytomegalovirus Infections with Ether Lipid Esters of Cidofovir
Earl R. Kern, Deborah J. Collins, W. Brad Wan, James R. Beadle, Karl Y. Hostetler, and Debra C. Quenelle
Antimicrob. Agents Chemother. September 2004 48: 3516-3522;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutation in Enterovirus 71 Capsid Protein VP1 Confers Resistance to the Inhibitory Effects of Pyridyl Imidazolidinone
Shin-Ru Shih, Mun-Chung Tsai, Sung-Nien Tseng, Kuo-Fang Won, Kak-Shan Shia, Wen-Tai Li, Jyh-Haur Chern, Guang-Wu Chen, Chung-Chi Lee, Yen-Chun Lee, Kuan-Chang Peng, and Yu-Sheng Chao
Antimicrob. Agents Chemother. September 2004 48: 3523-3529;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Nelfinavir Resistance Mutations on In Vitro Phenotype, Fitness, and Replication Capacity of Human Immunodeficiency Virus Type 1 with Subtype B and C Proteases
Luis M. F. Gonzalez, Rodrigo M. Brindeiro, Renato S. Aguiar, Helena S. Pereira, Celina M. Abreu, Marcelo A. Soares, and Amilcar Tanuri
Antimicrob. Agents Chemother. September 2004 48: 3552-3555;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Convenient Biological Assay for Polyethylene Glycol-Interferons in Patients with Hepatitis C
Anne Boulestin, Nassim Kamar, Florence Legrand-Abravanel, Karine Sandres-Saune, Laurent Alric, Jean-Pierre Vinel, Lionel Rostaing, and Jacques Izopet
Antimicrob. Agents Chemother. September 2004 48: 3610-3612;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

The Melaminophenyl Arsenicals Melarsoprol and Melarsen Oxide Interfere with Thiamine Metabolism in the Fission Yeast Schizosaccharomyces pombe
M. Ernst Schweingruber
Antimicrob. Agents Chemother. September 2004 48: 3268-3271;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional and Structural Characterization of the Genetic Environment of an Extended-Spectrum ß-Lactamase bla_VEB Gene from a Pseudomonas aeruginosa Isolate Obtained in India
Daniel Aubert, Delphine Girlich, Thierry Naas, Shanta Nagarajan, and Patrice Nordmann
Antimicrob. Agents Chemother. September 2004 48: 3284-3290;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Encoded Multidrug Efflux Pump Conferring Resistance to Olaquindox in Escherichia coli
Lars Hestbjerg Hansen, Elsebetta Johannesen, Mette Burmølle, Anders Hay Sørensen, and Søren J. Sørensen
Antimicrob. Agents Chemother. September 2004 48: 3332-3337;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Adherence of Candida albicans to Silicone Induces Immediate Enhanced Tolerance to Fluconazole
Carolina Mateus, Sidney A. Crow, Jr., and Donald G. Ahearn
Antimicrob. Agents Chemother. September 2004 48: 3358-3366;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Screening and Characterization of Mutations in Isoniazid-Resistant Mycobacterium tuberculosis Isolates Obtained in Brazil
Rosilene Fressatti Cardoso, Robert C. Cooksey, Glenn P. Morlock, Patricia Barco, Leticia Cecon, Francisco Forestiero, Clarice Q. F. Leite, Daisy N. Sato, Maria de Lourdes Shikama, Elsa M. Mamizuka, Rosario D. C. Hirata, and Mario H. Hirata
Antimicrob. Agents Chemother. September 2004 48: 3373-3381;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequence-Selective Recognition of Extended-Spectrum ß-Lactamase GES-2 by a Competitive, Peptide Nucleic Acid-Based Multiplex PCR Assay
Gerhard F. Weldhagen
Antimicrob. Agents Chemother. September 2004 48: 3402-3406;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genes Required for Intrinsic Multidrug Resistance in Mycobacterium avium
Julie S. Philalay, Christine O. Palermo, Kirsten A. Hauge, Tige R. Rustad, and Gerard A. Cangelosi
Antimicrob. Agents Chemother. September 2004 48: 3412-3418;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Incidence of Antibiotic Resistance in Campylobacter jejuni Isolated in Alberta, Canada, from 1999 to 2002, with Special Reference to tet(O)-Mediated Tetracycline Resistance
Amera Gibreel, Dobryan M. Tracz, Lisa Nonaka, Trinh M. Ngo, Sean R. Connell, and Diane E. Taylor
Antimicrob. Agents Chemother. September 2004 48: 3442-3450;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The mef(A) Gene Predominates among Seven Macrolide Resistance Genes Identified in Gram-Negative Strains Representing 13 Genera, Isolated from Healthy Portuguese Children
K. K. Ojo, C. Ulep, N. Van Kirk, H. Luis, M. Bernardo, J. Leitao, and M. C. Roberts
Antimicrob. Agents Chemother. September 2004 48: 3451-3456;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Basis of Resistance to Macrolides and Other Antibiotics in Commensal Viridans Group Streptococci and Gemella spp. and Transfer of Resistance Genes to Streptococcus pneumoniae
Paula Cerdá Zolezzi, Leticia Millán Laplana, Carmen Rubio Calvo, Pilar Goñi Cepero, Melisa Canales Erazo, and Rafael Gómez-Lus
Antimicrob. Agents Chemother. September 2004 48: 3462-3467;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increased Serum Resistance in Klebsiella pneumoniae Strains Producing Extended-Spectrum ß-Lactamases
H. Sahly, H. Aucken, V. J. Benedí, C. Forestier, V. Fussing, D. S. Hansen, I. Ofek, R. Podschun, D. Sirot, J. M. Tomás, D. Sandvang, and U. Ullmann
Antimicrob. Agents Chemother. September 2004 48: 3477-3482;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Terbinafine Resistance Mediated by Salicylate 1-Monooxygenase in Aspergillus nidulans
Marcia A. S. Graminha, Eleusa M. F. Rocha, Rolf A. Prade, and Nilce M. Martinez-Rossi
Antimicrob. Agents Chemother. September 2004 48: 3530-3535;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

An Internationally Spread Clone of Streptococcus pneumoniae Evolves from Low-Level to Higher-Level Penicillin Resistance by Uptake of Penicillin-Binding Protein Gene Fragments from Nonencapsulated Pneumococci
Christoph Hauser, Suzanne Aebi, and Kathrin Mühlemann
Antimicrob. Agents Chemother. September 2004 48: 3563-3566;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh
Rasel Khan, Shamsun Nahar, Jinath Sultana, Mian Mashhud Ahmad, and Motiur Rahman
Antimicrob. Agents Chemother. September 2004 48: 3567-3569;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinolone-Resistant Haemophilus influenzae in a Long-Term-Care Facility: Nucleotide Sequence Characterization of Alterations in the Genes Encoding DNA Gyrase and DNA Topoisomerase IV
Xinying Li, Noriel Mariano, James J. Rahal, Carl M. Urban, and Karl Drlica
Antimicrob. Agents Chemother. September 2004 48: 3570-3572;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of Association between Hypermutation and Antibiotic Resistance Development in Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients
Olivia Gutiérrez, Carlos Juan, José L. Pérez, and Antonio Oliver
Antimicrob. Agents Chemother. September 2004 48: 3573-3575;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isolation of an Integron-Borne bla_VIM-4 Type Metallo-ß-Lactamase Gene from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate in Hungary
Balázs Libisch, Mária Gacs, Károly Csiszár, Mónika Muzslay, László Rókusz, and Miklós Füzi
Antimicrob. Agents Chemother. September 2004 48: 3576-3578;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of Laboratory Mutants of Extended-Spectrum ß-Lactamase TEM-60
Bibiana Caporale, Nicola Franceschini, Mariagrazia Perilli, Bernardetta Segatore, Gian Maria Rossolini, and Gianfranco Amicosante
Antimicrob. Agents Chemother. September 2004 48: 3579-3582;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical-Use-Associated Decrease in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Linezolid: a Comparison with Quinupristin-Dalfopristin
Issam I. Raad, Hend A. Hanna, Ray Y. Hachem, Tanya Dvorak, Rebecca B. Arbuckle, Gassan Chaiban, and Louis B. Rice
Antimicrob. Agents Chemother. September 2004 48: 3583-3585;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic and Culture-Based Approaches for Detecting Macrolide Resistance in Chlamydia pneumoniae
Paul F. Riska, Andrei Kutlin, Patrick Ajiboye, Arnold Cua, Patricia M. Roblin, and Margaret R. Hammerschlag
Antimicrob. Agents Chemother. September 2004 48: 3586-3590;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Fusidic Acid-Resistant Epidemic Strain of Staphylococcus aureus Carries the fusB Determinant, whereas fusA Mutations Are Prevalent in Other Resistant Isolates
Alexander J. O'Neill, Anders R. Larsen, Anne S. Henriksen, and Ian Chopra
Antimicrob. Agents Chemother. September 2004 48: 3594-3597;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drug Susceptibility and Genetic Evaluation of Plasmodium falciparum Isolates Obtained in Four Distinct Geographical Regions of Kenya
Abigael Mbaisi, Pamela Liyala, Fredrick Eyase, Rachel Achilla, Hosea Akala, Julia Wangui, Josphat Mwangi, Finnley Osuna, Uzma Alam, Bonnie L. Smoak, Jon M. Davis, Dennis E. Kyle, Rodney L. Coldren, Carl Mason, and Norman C. Waters
Antimicrob. Agents Chemother. September 2004 48: 3598-3601;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Local Genetic Patterns within a Vancomycin-Resistant Enterococcus faecalis Clone Isolated in Three Hospitals in Portugal
Carla Novais, Teresa M. Coque, João Carlos Sousa, Fernando Baquero, and Luisa Peixe
Antimicrob. Agents Chemother. September 2004 48: 3613-3617;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux in Enterobacter aerogenes and Escherichia coli
Renaud Chollet, Jacqueline Chevalier, André Bryskier, and Jean-Marie Pagès
Antimicrob. Agents Chemother. September 2004 48: 3621-3624;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

National Surveillance of Methicillin-Resistant Staphylococcus aureus in Belgian Hospitals Indicates Rapid Diversification of Epidemic Clones
Olivier Denis, Ariane Deplano, Claire Nonhoff, Raf De Ryck, Ricardo de Mendonça, Sylvianne Rottiers, Raymond Vanhoof, and Marc J. Struelens
Antimicrob. Agents Chemother. September 2004 48: 3625-3629;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

In Vitro Activity of Caspofungin Combined with Sulfamethoxazole against Clinical Isolates of Aspergillus spp.
Aya Yekutiel, Itamar Shalit, Yona Shadkchan, and Nir Osherov
Antimicrob. Agents Chemother. September 2004 48: 3279-3283;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimicrobial Susceptibilities of Streptococcus pneumoniae Clinical Isolates Obtained in Canada in 2002
Jeff Powis, Allison McGeer, Karen Green, Otto Vanderkooi, Karl Weiss, George Zhanel, Tony Mazzulli, Magdalena Kuhn, Deirdre Church, Ross Davidson, Kevin Forward, Daryl Hoban, Andrew Simor, and Donald E. Low
Antimicrob. Agents Chemother. September 2004 48: 3305-3311;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Voriconazole in Combination with Three Other Antifungal Agents against Candida glabrata
Francesco Barchiesi, Elisabetta Spreghini, Monia Maracci, Annette W. Fothergill, Isabella Baldassarri, Michael G. Rinaldi, and Giorgio Scalise
Antimicrob. Agents Chemother. September 2004 48: 3317-3322;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of the New Quinolone WCK 771 against Staphylococci
Michael R. Jacobs, Saralee Bajaksouzian, Anne Windau, Peter C. Appelbaum, Mahesh V. Patel, Shrikant V. Gupte, Sachin S. Bhagwat, Noel J. De Souza, and Habil F. Khorakiwala
Antimicrob. Agents Chemother. September 2004 48: 3338-3342;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Paradoxical Effect of Caspofungin: Reduced Activity against Candida albicans at High Drug Concentrations
David A. Stevens, Marife Espiritu, and Rachana Parmar
Antimicrob. Agents Chemother. September 2004 48: 3407-3411;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Levofloxacin-Resistant Invasive Streptococcus pneumoniae in the United States: Evidence for Clonal Spread and the Impact of Conjugate Pneumococcal Vaccine
Mathias W. R. Pletz, Lesley McGee, James Jorgensen, Bernard Beall, Richard R. Facklam, Cynthia G. Whitney, and Keith P. Klugman
Antimicrob. Agents Chemother. September 2004 48: 3491-3497;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Macrolide-Resistant Streptococcus pyogenes Strains in French Children
Edouard Bingen, Philippe Bidet, Liliana Mihaila-Amrouche, Catherine Doit, Samuel Forcet, Naïma Brahimi, Anne Bouvet, and Robert Cohen
Antimicrob. Agents Chemother. September 2004 48: 3559-3562;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Colonization with Extraintestinal Pathogenic Escherichia coli among Nursing Home Residents and Its Relationship to Fluoroquinolone Resistance
Joel N. Maslow, Ebbing Lautenbach, Thomas Glaze, Warren Bilker, and James R. Johnson
Antimicrob. Agents Chemother. September 2004 48: 3618-3620;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Designing Fluoroquinolone Breakpoints for Streptococcus pneumoniae by Using Genetics instead of Pharmacokinetics-Pharmacodynamics
H. J. Smith, A. M. Noreddin, C. G. Siemens, K. N. Schurek, J. Greisman, C. J. Hoban, D. J. Hoban, and G. G. Zhanel
Antimicrob. Agents Chemother. September 2004 48: 3630-3635;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Invasive Streptococcus pneumoniae in France: Antimicrobial Resistance, Serotype, and Molecular Epidemiology Findings from a Monthly National Study in 2000 to 2002
Jean-Winoc Decousser, Patrick Pina, Florent Viguier, Franc Picot, Patrice Courvalin, and Pierre Allouch
Antimicrob. Agents Chemother. September 2004 48: 3636-3639;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Double-Blind, Randomized Study of the Efficacy and Safety of Oral Pharmacokinetically Enhanced Amoxicillin-Clavulanate (2,000/125 Milligrams) versus Those of Amoxicillin-Clavulanate (875/125 Milligrams), Both Given Twice Daily for 7 Days, in Treatment of Bacterial Community-Acquired Pneumonia in Adults
T. M. File, Jr., H. Lode, H. Kurz, R. Kozak, H. Xie, and E. Berkowitz
Antimicrob. Agents Chemother. September 2004 48: 3323-3331;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemistry; Biosynthesis:

De Novo Design of Potent Antimicrobial Peptides
V. Frecer, B. Ho, and J. L. Ding
Antimicrob. Agents Chemother. September 2004 48: 3349-3357;
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Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in "Streptomyces carzinostaticus"
Miyuki Otsuka, Koji Ichinose, Isao Fujii, and Yutaka Ebizuka
Antimicrob. Agents Chemother. September 2004 48: 3468-3476;
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Activities of Dicationic Compounds against Trichomonas vaginalis
Andrea L. Crowell, Chad E. Stephens, Arvind Kumar, David W. Boykin, and W. Evan Secor
Antimicrob. Agents Chemother. September 2004 48: 3602-3605;
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Letters:

Insufficient Evidence that Extended-Spectrum Cephalosporins Effectively Prevent Metastatic Infections Related to Klebsiella pneumoniae-Caused Liver Abscess
Susan Shin-Jung Lee, Yung-Ching Liu, Yao-Shen Chen, Hung-Chin Tsai, Shue-Ren Wann, Chih-Hsiang Kao, Feng-Yee Chang, and L. K. Siu
Antimicrob. Agents Chemother. September 2004 48: 3640-3641;
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Moxifloxacin Treatment of Tuberculosis
Roland Gosling, Stephen Gillespie, Mathias W. R. Pletz, and Hartmut Lode
Antimicrob. Agents Chemother. September 2004 48: 3642-3643;
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