Contents: May 2005, Volume 49, Issue 5        Minireviews        Experimental Therapeutics        Mechanisms of Resistance        Pharmacology        Antiviral Agents        Mechanisms of Action        Susceptibility        Letters        Recent Approvals        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Changing Patterns in the Selection of Viral Mutations among Patients Receiving Nucleoside and Nucleotide Drug Combinations Directed against Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mark A. Wainberg, Bluma G. Brenner, and Dan Turner Antimicrob. Agents Chemother. May 2005 49: 1671-1678; [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Antileishmanial Activity of the Terpene Nerolidol Denise C. Arruda, Fabio Luiz D'Alexandri, Alejandro M. Katzin, and Silvia R. B. Uliana Antimicrob. Agents Chemother. May 2005 49: 1679-1687; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Therapy of Experimental Cerebral Phaeohyphomycosis Due to Cladophialophora bantiana Hail M. Al-Abdely, Laura K. Najvar, Rosie Bocanegra, and John R. Graybill Antimicrob. Agents Chemother. May 2005 49: 1701-1707; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Application of an In Vitro Infection Model and Simulation for Reevaluation of Fluoroquinolone Breakpoints for Salmonella enterica Serotype Typhi Brent M. Booker, Patrick F. Smith, Alan Forrest, Julie Bullock, Pamela Kelchlin, Sujata M. Bhavnani, Ronald N. Jones, and Paul G. Ambrose Antimicrob. Agents Chemother. May 2005 49: 1775-1781; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Activity of Telithromycin at Simulated Clinically Achievable Free-Drug Concentrations in Serum and Epithelial Lining Fluid against Efflux (mefE)-Producing Macrolide- Resistant Streptococcus pneumoniae for Which Telithromycin MICs Vary George G. Zhanel, Christel Johanson, Nancy Laing, Tamiko Hisanaga, Aleksandra Wierzbowski, and Daryl J. Hoban Antimicrob. Agents Chemother. May 2005 49: 1943-1948; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Benznidazole Therapy in Trypanosoma cruzi-Infected Mice Blocks Thymic Involution and Apoptosis of CD4+CD8+ Double-Positive Thymocytes B. P. Olivieri, D. A. Farias-De-Oliveira, T. C. Araujo-Jorge, and V. Cotta-de-Almeida Antimicrob. Agents Chemother. May 2005 49: 1981-1987; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy, Plasma Pharmacokinetics, and Safety of Icofungipen, an Inhibitor of Candida Isoleucyl-tRNA Synthetase, in Treatment of Experimental Disseminated Candidiasis in Persistently Neutropenic Rabbits Ruta Petraitiene, Vidmantas Petraitis, Amy M. Kelaher, Alia A. Sarafandi, Diana Mickiene, Andreas H. Groll, Tin Sein, John Bacher, and Thomas J. Walsh Antimicrob. Agents Chemother. May 2005 49: 2084-2092; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Molecular Characterization of vanB Elements in Naturally Occurring Gut Anaerobes S. A. Ballard, K. K. Pertile, M. Lim, P. D. R. Johnson, and M. L. Grayson Antimicrob. Agents Chemother. May 2005 49: 1688-1694; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Environment and Expression of the Extended-Spectrum ß-Lactamase blaPER-1 Gene in Gram-Negative Bacteria Laurent Poirel, Ludovic Cabanne, Haluk Vahaboglu, and Patrice Nordmann Antimicrob. Agents Chemother. May 2005 49: 1708-1713; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Mutations in the gyrA Gene and Quinolone Resistance in Clinical Isolates of Corynebacterium striatum and Corynebacterium amycolatum Josep M. Sierra, Luis Martinez-Martinez, Fernando Vázquez, Ernest Giralt, and Jordi Vila Antimicrob. Agents Chemother. May 2005 49: 1714-1719; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes Sarah MacPherson, Bassel Akache, Sandra Weber, Xavier De Deken, Martine Raymond, and Bernard Turcotte Antimicrob. Agents Chemother. May 2005 49: 1745-1752; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Assessment of the Further Potential for Development of Fluoroquinolone Resistance in Neisseria meningitidis Tiffany R. Shultz, Peter A. White, and John W. Tapsall Antimicrob. Agents Chemother. May 2005 49: 1753-1760; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in PA3574 (nalD) Lead to Increased MexAB-OprM Expression and Multidrug Resistance in Laboratory and Clinical Isolates of Pseudomonas aeruginosa Mara L. Sobel, Didier Hocquet, Lily Cao, Patrick Plesiat, and Keith Poole Antimicrob. Agents Chemother. May 2005 49: 1782-1786; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Incidence of Class 1 Integrons in a Quaternary Ammonium Compound-Polluted Environment W. H. Gaze, N. Abdouslam, P. M. Hawkey, and E. M. H. Wellington Antimicrob. Agents Chemother. May 2005 49: 1802-1807; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron Content of Extended-Spectrum-ß-Lactamase-Producing Escherichia coli Strains over 12 Years in a Single Hospital in Madrid, Spain Elisabete Machado, Rafael Cantón, Fernando Baquero, Juan-Carlos Galán, Azucena Rollán, Luísa Peixe, and Teresa M. Coque Antimicrob. Agents Chemother. May 2005 49: 1823-1829; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of MexL, the Transcriptional Repressor of the mexJK Multidrug Efflux Operon in Pseudomonas aeruginosa Rungtip Chuanchuen, Jared B. Gaynor, RoxAnn Karkhoff-Schweizer, and Herbert P. Schweizer Antimicrob. Agents Chemother. May 2005 49: 1844-1851; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidrug Resistance in Staphylococcus aureus Due to Overexpression of a Novel Multidrug and Toxin Extrusion (MATE) Transport Protein Glenn W. Kaatz, Fionnuala McAleese, and Susan M. Seo Antimicrob. Agents Chemother. May 2005 49: 1857-1864; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline Fionnuala McAleese, Peter Petersen, Alexey Ruzin, Paul M. Dunman, Ellen Murphy, Steven J. Projan, and Patricia A. Bradford Antimicrob. Agents Chemother. May 2005 49: 1865-1871; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evolution of TEM-Type Extended-Spectrum ß-Lactamases in Clinical Enterobacteriaceae Strains in Poland Anna Baraniak, Janusz Fiett, Agnieszka Mrówka, Jaroslaw Walory, Waleria Hryniewicz, and Marek Gniadkowski Antimicrob. Agents Chemother. May 2005 49: 1872-1880; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Encoded Tet B Tetracycline Resistance in Haemophilus parasuis John F. Lancashire, Tamsin D. Terry, P. J. Blackall, and Michael P. Jennings Antimicrob. Agents Chemother. May 2005 49: 1927-1931; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cloning and Characterization of a Chromosomal Class C ß-Lactamase and Its Regulatory Gene in Laribacter hongkongensis Susanna K. P. Lau, Pak-leung Ho, Maria W. S. Li, Hoi-wah Tsoi, Raymond W. H. Yung, Patrick C. Y. Woo, and Kwok-yung Yuen Antimicrob. Agents Chemother. May 2005 49: 1957-1964; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

OXA-46, a New Class D ß-Lactamase of Narrow Substrate Specificity Encoded by a blaVIM-1-Containing Integron from a Pseudomonas aeruginosa Clinical Isolate Francesco Giuliani, Jean-Denis Docquier, Maria Letizia Riccio, Laura Pagani, and Gian Maria Rossolini Antimicrob. Agents Chemother. May 2005 49: 1973-1980; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of the ABC Transporter MRPA (PGPA) in Antimony Resistance in Leishmania infantum Axenic and Intracellular Amastigotes Karima El Fadili, Nadine Messier, Philippe Leprohon, Gaétan Roy, Chantal Guimond, Nathalie Trudel, Nancy G. Saravia, Barbara Papadopoulou, Danielle Légaré, and Marc Ouellette Antimicrob. Agents Chemother. May 2005 49: 1988-1993; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Altered PBP 2A and Its Role in the Development of Penicillin, Cefotaxime, and Ceftriaxone Resistance in a Clinical Isolate of Streptococcus pneumoniae Anthony M. Smith, Charles Feldman, Orietta Massidda, Kerrigan McCarthy, Dalu Ndiweni, and Keith P. Klugman Antimicrob. Agents Chemother. May 2005 49: 2002-2007; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Seven Novel Variants of the Staphylococcal Chromosomal Cassette mec in Methicillin-Resistant Staphylococcus aureus Isolates from Ireland Anna Shore, Angela S. Rossney, Conor T. Keane, Mark C. Enright, and David C. Coleman Antimicrob. Agents Chemother. May 2005 49: 2070-2083; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Spread of a Klebsiella pneumoniae Strain Producing a Plasmid- Mediated ACC-1 AmpC ß-Lactamase in a Teaching Hospital Admitting Disabled Patients Salomon Ohana, Veronique Leflon, Esthel Ronco, Martin Rottman, Didier Guillemot, Sylvie Lortat-Jacob, Pierre Denys, Georges Loubert, Marie-Helène Nicolas-Chanoine, Jean-Louis Gaillard, and Christine Lawrence Antimicrob. Agents Chemother. May 2005 49: 2095-2097; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hypermutable and Fluoroquinolone-Resistant Clinical Isolates of Staphylococcus aureus Hiep N'Guyen Trong, Anne-Laure Prunier, and Roland Leclercq Antimicrob. Agents Chemother. May 2005 49: 2098-2101; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Origin and Dissemination of Chloroquine-Resistant Plasmodium falciparum with Mutant pfcrt Alleles in the Philippines Nanhua Chen, Danny W. Wilson, Cielo Pasay, David Bell, Laura B. Martin, Dennis Kyle, and Qin Cheng Antimicrob. Agents Chemother. May 2005 49: 2102-2105; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Florfenicol Resistance Gene floR Is Part of a Novel Transposon Benoît Doublet, Stefan Schwarz, Corinna Kehrenberg, and Axel Cloeckaert Antimicrob. Agents Chemother. May 2005 49: 2106-2108; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Inversion of the Prevalences of Macrolide Resistance Phenotypes Paralleled by a Diversification of T and emm Types among Streptococcus pyogenes in Portugal C. Silva-Costa, M. Ramirez, J. Melo-Cristino the Portuguese Surveillance Group for the Study of Respiratory Pathogens Antimicrob. Agents Chemother. May 2005 49: 2109-2111; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of a Progenitor of the CTX-M-9 Group of Extended-Spectrum ß-Lactamases from Kluyvera georgiana Isolated in Guyana Adam B. Olson, M. Silverman, David A. Boyd, Allison McGeer, Barbara M. Willey, V. Pong-Porter, N. Daneman, and Michael R. Mulvey Antimicrob. Agents Chemother. May 2005 49: 2112-2115; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differences in Interactions between Azole Drugs Related to Modifications in the 14- Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus G. Garcia-Effron, E. Mellado, A. Gomez-Lopez, L. Alcazar-Fuoli, M. Cuenca-Estrella, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. May 2005 49: 2119-2121; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nationwide Study of Escherichia coli and Klebsiella pneumoniae Producing Extended-Spectrum ß-Lactamases in Spain J. R. Hernández, L. Martínez-Martínez, R. Cantón, T. M. Coque, A. Pascual Spanish Group for Nosocomial Infections (GEIH) Antimicrob. Agents Chemother. May 2005 49: 2122-2125; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Genetic Diversity of Ciprofloxacin-Nonsusceptible Isolates of Streptococcus pneumoniae in Poland Ewa Sadowy, Radoslaw Izdebski, Anna Skoczynska, Marek Gniadkowski, and Waleria Hryniewicz Antimicrob. Agents Chemother. May 2005 49: 2126-2129; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence and Characterization of Invasive Isolates of Streptococcus pyogenes with Reduced Susceptibility to Fluoroquinolones Jeff Powis, Allison McGeer, Carla Duncan, Ryan Goren, Joyce C. S. de Azavedo, Darrin J. Bast, Sylvia Pong-Porter, Tony Mazzulli, Karen Green, Barbara Willey, and Donald E. Low Antimicrob. Agents Chemother. May 2005 49: 2130-2132; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Substrate-Dependent Utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK Efflux Pump Rungtip Chuanchuen, Takeshi Murata, Naomasa Gotoh, and Herbert P. Schweizer Antimicrob. Agents Chemother. May 2005 49: 2133-2136; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Mixed-Lipid Storage Disorder Induced in Macrophages and Fibroblasts by Oritavancin (LY333328), a New Glycopeptide Antibiotic with Exceptional Cellular Accumulation Françoise Van Bambeke, Jennifer Saffran, Marie-Paule Mingeot-Leclercq, and Paul M. Tulkens Antimicrob. Agents Chemother. May 2005 49: 1695-1700; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Should We Use N-Acetyltransferase Type 2 Genotyping To Personalize Isoniazid Doses? Martina Kinzig-Schippers, Dorota Tomalik-Scharte, Alexander Jetter, Bernhard Scheidel, Verena Jakob, Michael Rodamer, Ingolf Cascorbi, Oxana Doroshyenko, Fritz Sörgel, and Uwe Fuhr Antimicrob. Agents Chemother. May 2005 49: 1733-1738; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phase 1 Safety and Pharmacokinetic Study of Chimeric Murine-Human Monoclonal Antibody cStx2 Administered Intravenously to Healthy Adult Volunteers Thomas C. Dowling, Pierre A. Chavaillaz, David G. Young, Angela Melton-Celsa, Alison O'Brien, Claire Thuning-Roberson, Robert Edelman, and Carol O. Tacket Antimicrob. Agents Chemother. May 2005 49: 1808-1812; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Pharmacokinetics of Alamifovir and Its Metabolites Clark Chan, Eyas Abu-Raddad, Georg Golor, Hikari Watanabe, Akira Sasaki, Kwee Poo Yeo, Danny Soon, Vikram P. Sinha, Shawn D. Flanagan, Minxia M. He, and Stephen D. Wise Antimicrob. Agents Chemother. May 2005 49: 1813-1822; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation by Monte Carlo Simulation of the Pharmacokinetics of Two Doses of Meropenem Administered Intermittently or as a Continuous Infusion in Healthy Volunteers Wolfgang A. Krueger, Jurgen Bulitta, Martina Kinzig-Schippers, Cornelia Landersdorfer, Ulrike Holzgrabe, Kurt G. Naber, George L. Drusano, and Fritz Sörgel Antimicrob. Agents Chemother. May 2005 49: 1881-1889; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Virological and Pharmacological Parameters Predicting the Response to Lopinavir-Ritonavir in Heavily Protease Inhibitor-Experienced Patients Anne-Geneviève Marcelin, Isabelle Cohen-Codar, Martin S. King, Philippe Colson, Emmanuel Guillevic, Diane Descamps, Claire Lamotte, Véronique Schneider, Jacques Ritter, Michel Segondy, Hélène Peigue-Lafeuille, Laurence Morand-Joubert, Anne Schmuck, Annick Ruffault, Pierre Palmer, Marie-Laure Chaix, Vincent Mackiewicz, Véronique Brodard, Jacques Izopet, Jacqueline Cottalorda, Evelyne Kohli, Jean-Pierre Chauvin, Dale J. Kempf, Gilles Peytavin, and Vincent Calvez Antimicrob. Agents Chemother. May 2005 49: 1720-1726; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinically Relevant Genotype Interpretation of Resistance to Didanosine Anne-Geneviève Marcelin, Philippe Flandre, Juliette Pavie, Nathalie Schmidely, Marc Wirden, Olivier Lada, Dan Chiche, Jean-Michel Molina, Vincent Calvez the AI454-176 Jaguar Study Team Antimicrob. Agents Chemother. May 2005 49: 1739-1744; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Substrates for the Primer-Unblocking Reaction by Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Detection and Quantitation in Extracts from Quiescent- and Activated-Lymphocyte Subpopulations Anthony J. Smith, Peter R. Meyer, Deshratn Asthana, Margarita R. Ashman, and Walter A. Scott Antimicrob. Agents Chemother. May 2005 49: 1761-1769; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination of Candidate Microbicides Cellulose Acetate 1,2-Benzenedicarboxylate and UC781 Has Synergistic and Complementary Effects against Human Immunodeficiency Virus Type 1 Infection Shuwen Liu, Hong Lu, A. Robert Neurath, and Shibo Jiang Antimicrob. Agents Chemother. May 2005 49: 1830-1836; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue William A. Lee, Gong-Xin He, Eugene Eisenberg, Tomas Cihlar, Swami Swaminathan, Andrew Mulato, and Kenneth C. Cundy Antimicrob. Agents Chemother. May 2005 49: 1898-1906; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Measurement of Intracellular Didanosine and Tenofovir Phosphorylated Metabolites and Possible Interaction of the Two Drugs in Human Immunodeficiency Virus-Infected Patients Alain Pruvost, Eugènia Negredo, Henri Benech, Frédéric Theodoro, Jordi Puig, Eulàlia Grau, Elisabet García, José Moltó, Jacques Grassi, and Bonaventura Clotet Antimicrob. Agents Chemother. May 2005 49: 1907-1914; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Anti-Human Immunodeficiency Virus Activity of ß-D-6-Cyclopropylamino-2',3'-Didehydro-2',3'-Dideoxyguanosine Adrian S. Ray, Brenda I. Hernandez-Santiago, Judy S. Mathew, Eisuke Murakami, Carey Bozeman, Meng-Yu Xie, Ginger E. Dutschman, Elizabeth Gullen, Zhenjun Yang, Selwyn Hurwitz, Yung-Chi Cheng, Chung K. Chu, Harold McClure, Raymond F. Schinazi, and Karen S. Anderson Antimicrob. Agents Chemother. May 2005 49: 1994-2001; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Human Immunodeficiency Virus Type 1 Protease Mutations Potentially Involved in Resistance to Protease Inhibitors Valentina Svicher, Francesca Ceccherini-Silberstein, Fulvio Erba, Maria Santoro, Caterina Gori, Maria Concetta Bellocchi, Sara Giannella, Maria Paola Trotta, Antonella d'Arminio Monforte, Andrea Antinori, and Carlo Federico Perno Antimicrob. Agents Chemother. May 2005 49: 2015-2025; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Targeting Tn5 Transposase Identifies Human Immunodeficiency Virus Type 1 Inhibitors Brandon Ason, Daniel J. Knauss, Allison M. Balke, George Merkel, Anna Marie Skalka, and William S. Reznikoff Antimicrob. Agents Chemother. May 2005 49: 2035-2043; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Behavior of Thymidylate Kinase toward Monophosphate Metabolites and Its Role in the Metabolism of 1-(2'-Deoxy-2'-Fluoro-ß-L-Arabinofuranosyl)-5-Methyluracil (Clevudine) and 2',3'-Didehydro-2',3'-Dideoxythymidine in Cells Rong Hu, Ling Li, Bart Degrève, Ginger E. Dutschman, Wing Lam, and Yung-Chi Cheng Antimicrob. Agents Chemother. May 2005 49: 2044-2049; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells Joanne E. Tomassini, Krista Getty, Mark W. Stahlhut, Sung Shim, Balkrishen Bhat, Anne B. Eldrup, Thazha P. Prakash, Steven S. Carroll, Osvaldo Flores, Malcolm MacCoss, Daniel R. McMasters, Giovanni Migliaccio, and David B. Olsen Antimicrob. Agents Chemother. May 2005 49: 2050-2058; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay Steven W. Ludmerer, Donald J. Graham, Evelyn Boots, Edward M. Murray, Amy Simcoe, Eric J. Markel, Jay A. Grobler, Osvaldo A. Flores, David B. Olsen, Daria J. Hazuda, and Robert L. LaFemina Antimicrob. Agents Chemother. May 2005 49: 2059-2069; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Pharmacokinetics of Tenofovir in Breast Milk of Lactating Rhesus Macaques Koen K. A. Van Rompay, Marta Hamilton, Brian Kearney, and Norbert Bischofberger Antimicrob. Agents Chemother. May 2005 49: 2093-2094; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Immunomodulatory Activities of Small Host Defense Peptides Dawn M. E. Bowdish, Donald J. Davidson, Monisha G. Scott, and Robert E. W. Hancock Antimicrob. Agents Chemother. May 2005 49: 1727-1732; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biphasic Effects of Geranylgeraniol, Teprenone, and Phytol on the Growth of Staphylococcus aureus Yoshihiro Inoue, Toshiko Hada, Akiko Shiraishi, Kazuma Hirose, Hajime Hamashima, and Shigeki Kobayashi Antimicrob. Agents Chemother. May 2005 49: 1770-1774; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Effect of Aureobasidin A on Toxoplasma gondii Sabrina Sonda, Giusy Sala, Riccardo Ghidoni, Andrew Hemphill, and Jean Pieters Antimicrob. Agents Chemother. May 2005 49: 1794-1801; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Imidazole Antibiotics Inhibit the Nitric Oxide Dioxygenase Function of Microbial Flavohemoglobin Ryan A. Helmick, Arin E. Fletcher, Anne M. Gardner, Christopher R. Gessner, Angela N. Hvitved, Michael C. Gustin, and Paul R. Gardner Antimicrob. Agents Chemother. May 2005 49: 1837-1843; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA Linus L. Shen, Candace Black-Schaefer, Yingna Cai, Peter J. Dandliker, and Bruce A. Beutel Antimicrob. Agents Chemother. May 2005 49: 1890-1897; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Global Transcriptional Response of Bacillus subtilis to Treatment with Subinhibitory Concentrations of Antibiotics That Inhibit Protein Synthesis Janine T. Lin, Mariah Bindel Connelly, Chris Amolo, Suzie Otani, and Debbie S. Yaver Antimicrob. Agents Chemother. May 2005 49: 1915-1926; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dual Targeting of Topoisomerase IV and Gyrase To Reduce Mutant Selection: Direct Testing of the Paradigm by Using WCK-1734, a New Fluoroquinolone, and Ciprofloxacin Jacob Strahilevitz and David C. Hooper Antimicrob. Agents Chemother. May 2005 49: 1949-1956; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol Muhammad Malik, Tao Lu, Xilin Zhao, Anubha Singh, Christopher M. Hattan, John Domagala, Robert Kerns, and Karl Drlica Antimicrob. Agents Chemother. May 2005 49: 2008-2014; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanistic Study of the Photodynamic Inactivation of Candida albicans by a Cationic Porphyrin S. A. G. Lambrechts, M. C. G. Aalders, and J. Van Marle Antimicrob. Agents Chemother. May 2005 49: 2026-2034; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Bactericidal Activity of First-Choice Antibiotics against Gamma Interferon-Induced Persistent Infection of Human Epithelial Cells by Chlamydia trachomatis Nathalie Reveneau, Deborah D. Crane, Elizabeth Fischer, and Harlan D. Caldwell Antimicrob. Agents Chemother. May 2005 49: 1787-1793; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Growth Cycle-Dependent Pharmacodynamics of Antichlamydial Drugs Katrin Siewert, Jan Rupp, Matthias Klinger, Werner Solbach, and Jens Gieffers Antimicrob. Agents Chemother. May 2005 49: 1852-1856; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antipneumococcal Activity of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin Klaudia Kosowska, Dianne B. Hoellman, Gengrong Lin, Catherine Clark, Kim Credito, Pamela McGhee, Bonifacio Dewasse, Bülent Bozdogan, Stuart Shapiro, and Peter C. Appelbaum Antimicrob. Agents Chemother. May 2005 49: 1932-1942; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Geographical and Ecological Analysis of Resistance, Coresistance, and Coupled Resistance to Antimicrobials in Respiratory Pathogenic Bacteria in Spain Emilio Pérez-Trallero, Celia García-de-la-Fuente, César García-Rey, Fernando Baquero, Lorenzo Aguilar, Rafael Dal-Ré, Juan García-de-Lomas the Spanish Surveillance Group for Respiratory Pathogens Antimicrob. Agents Chemother. May 2005 49: 1965-1972; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Disk Diffusion Method for Determining Eberconazole Susceptibility of Dermatophytes and Influence of Culture Medium Belkys Fernández-Torres, Isabel Inza, and Josep Guarro Antimicrob. Agents Chemother. May 2005 49: 2116-2118; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Levels of Antimicrobial Coresistance among Extended-Spectrum-ß-Lactamase-Producing Enterobacteriaceae Mitchell J. Schwaber, Shiri Navon-Venezia, David Schwartz, and Yehuda Carmeli Antimicrob. Agents Chemother. May 2005 49: 2137-2139; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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First Isolation of blaVIM-2 in an Environmental Isolate of Pseudomonas pseudoalcaligenes Sandra Quinteira, Helena Ferreira, and Luísa Peixe Antimicrob. Agents Chemother. May 2005 49: 2140-2141; [Full Text] [PDF] [Reprints and Permissions]

Salmonella enterica Serovar Infantis Producing a CTX-M-9 ß-Lactamase Emilio Valverde Romero, Trinidad Parras Padilla, M. Inmaculada García García, Nuria Delgado Ronda, Ana Herrero, Juan Luis Muñoz Bellido, and José Ángel García Rodríguez Antimicrob. Agents Chemother. May 2005 49: 2142-2143; [Full Text] [PDF] [Reprints and Permissions]

Vibrio parahaemolyticus Chromosomal qnr Homologue VPA0095: Demonstration by Transformation with a Mutated Gene of Its Potential To Reduce Quinolone Susceptibility in Escherichia coli Tomoo Saga, Mitsuo Kaku, Yoshikuni Onodera, Shinichiro Yamachika, Kenichi Sato, and Hiroyuki Takase Antimicrob. Agents Chemother. May 2005 49: 2144-2145; [Full Text] [PDF] [Reprints and Permissions]

Further Identification of Plasmid-Mediated Quinolone Resistance Determinant in Enterobacteriaceae in Turkey Hasan Nazic, Laurent Poirel, and Patrice Nordmann Antimicrob. Agents Chemother. May 2005 49: 2146-2147; [Full Text] [PDF] [Reprints and Permissions]

Nomenclature of GES-Type Extended-Spectrum ß-Lactamases Sang Hee Lee, Seok Hoon Jeong, Jun-ichi Wachino, Yoshichika Arakawa, L. Poirel, and P. Nordmann Antimicrob. Agents Chemother. May 2005 49: 2148-2150; [Full Text] [PDF] [Reprints and Permissions]

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Recent Approvals:

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New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 2004 and New Indications for Previously Approved Agents Antimicrob. Agents Chemother. May 2005 49: 2151 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Emergence of Daptomycin Resistance in Enterococcus faecium during Daptomycin Therapy Antimicrob. Agents Chemother. May 2005 49: 2152 [Full Text] [PDF] [Reprints and Permissions]

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