Contents: July 2005, Volume 49, Issue 7        Minireviews        Mechanisms of Action        Antiviral Agents        Clinical Therapeutics        Susceptibility        Mechanisms of Resistance        Experimental Therapeutics        Chemistry; Biosynthesis        Pharmacology        Biologic Response Modifiers        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Insertions in the Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Genes: Clinical Impact and Molecular Mechanisms Mark A. Winters and Thomas C. Merigan Antimicrob. Agents Chemother. July 2005 49: 2575-2582; [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Different Anti-Candida Activities of Two Human Lactoferrin-Derived Peptides, Lfpep and Kaliocin-1 Mónica Viejo-Díaz, María T. Andrés, and José F. Fierro Antimicrob. Agents Chemother. July 2005 49: 2583-2588; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequential Actions of the Two Component Peptides of the Lantibiotic Lacticin 3147 Explain Its Antimicrobial Activity at Nanomolar Concentrations Sheila M. Morgan, Paula M. O'Connor, Paul D. Cotter, R. Paul Ross, and Colin Hill Antimicrob. Agents Chemother. July 2005 49: 2606-2611; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Helicobacter pylori Accumulates Photoactive Porphyrins and Is Killed by Visible Light Michael R. Hamblin, Jennifer Viveiros, Changming Yang, Atosa Ahmadi, Robert A. Ganz, and M. Joshua Tolkoff Antimicrob. Agents Chemother. July 2005 49: 2822-2827; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial and Chemoattractant Activity, Lipopolysaccharide Neutralization, Cytotoxicity, and Inhibition by Serum of Analogs of Human Cathelicidin LL-37 Cristina D. Ciornei, Thorgerdur Sigurdardóttir, Artur Schmidtchen, and Mikael Bodelsson Antimicrob. Agents Chemother. July 2005 49: 2845-2850; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

3-Aminooxy-1-Aminopropane and Derivatives Have an Antiproliferative Effect on Cultured Plasmodium falciparum by Decreasing Intracellular Polyamine Concentrations Robin Das Gupta, Tanja Krause-Ihle, Bärbel Bergmann, Ingrid B. Müller, Alex R. Khomutov, Sylke Müller, Rolf D. Walter, and Kai Lüersen Antimicrob. Agents Chemother. July 2005 49: 2857-2864; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifolate Activity of Epigallocatechin Gallate against Stenotrophomonas maltophilia María Dolores Navarro-Martínez, Enma Navarro-Perán, Juan Cabezas-Herrera, Joaquín Ruiz-Gómez, Francisco García-Cánovas, and José Neptuno Rodríguez-López Antimicrob. Agents Chemother. July 2005 49: 2914-2920; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Peptides Selected for Binding to a Virulent Strain of Haemophilus influenzae by Phage Display Are Bactericidal Sharon L. Bishop-Hurley, Francis J. Schmidt, Alice L. Erwin, and Arnold L. Smith Antimicrob. Agents Chemother. July 2005 49: 2972-2978; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cooperative Uptake of Microcin E492 by Receptors FepA, Fiu, and Cir and Inhibition by the Siderophore Enterochelin and Its Dimeric and Trimeric Hydrolysis Products Erwin Strahsburger, Marcelo Baeza, Octavio Monasterio, and Rosalba Lagos Antimicrob. Agents Chemother. July 2005 49: 3083-3086; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sublethal Concentrations of Ciprofloxacin Induce Bacteriocin Synthesis in Escherichia coli Borut Jerman, Matej Butala, and Darja Zgur-Bertok Antimicrob. Agents Chemother. July 2005 49: 3087-3090; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Pharmacology and Pharmacokinetics of the Antiviral Agent ß-D-2',3'-Dideoxy-3'-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys Brenda I. Hernandez-Santiago, Huachun Chen, Ghazia Asif, Thierry Beltran, Shuli Mao, Selwyn J. Hurwitz, Jason Grier, Harold M. McClure, Chung K. Chu, Dennis C. Liotta, and Raymond F. Schinazi Antimicrob. Agents Chemother. July 2005 49: 2589-2597; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of a Novel Mutation in the FLLA Region of Hepatitis B Virus during Lamivudine Therapy S. Balakrishna Pai, A. Mithat Bozdayi, Rekha B. Pai, Tolunay Beker, Mustafa Sarioglu, Ahmet R. Turkyilmaz, Jason Grier, Cihan Yurdaydin, and Raymond F. Schinazi Antimicrob. Agents Chemother. July 2005 49: 2618-2624; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biological Activity of an Intravenous Preparation of Human Vaccinia Immune Globulin in Mouse Models of Vaccinia Virus Infection Jeffry D. Shearer, Linda Siemann, Mary Gerkovich, and Robert V. House Antimicrob. Agents Chemother. July 2005 49: 2634-2641; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The L74V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Counteracts Enhanced Excision of Zidovudine Monophosphate Associated with Thymidine Analog Resistance Mutations Luis R. Miranda, Matthias Götte, and Daniel R. Kuritzkes Antimicrob. Agents Chemother. July 2005 49: 2648-2656; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impaired Rescue of Chain-Terminated DNA Synthesis Associated with the L74V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Fernando A. Frankel, Bruno Marchand, Dan Turner, Matthias Götte, and Mark A. Wainberg Antimicrob. Agents Chemother. July 2005 49: 2657-2664; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene Sunwen Chou, Laura C. Van Wechel, Heather M. Lichy, and Gail I. Marousek Antimicrob. Agents Chemother. July 2005 49: 2710-2715; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Effect of Oral Administration of Tenofovir Disoproxil Fumarate in Woodchucks with Chronic Woodchuck Hepatitis Virus Infection Stephan Menne, Paul J. Cote, Brent E. Korba, Scott D. Butler, Andrea L. George, Ilia A. Tochkov, William E. Delaney, IV, Shelly Xiong, John L. Gerin, and Bud C. Tennant Antimicrob. Agents Chemother. July 2005 49: 2720-2728; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Short-Term Safety of 873140, a Novel CCR5 Antagonist, in Healthy Adult Subjects Kimberly K. Adkison, Anne Shachoy-Clark, Lei Fang, Yu Lou, Kathy O'Mara, M. Michelle Berrey, and Stephen C. Piscitelli Antimicrob. Agents Chemother. July 2005 49: 2802-2806; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety, Pharmacokinetics, and Efficacy of (+/–)-ß-2',3'-Dideoxy-5-Fluoro-3'-Thiacytidine with Efavirenz and Stavudine in Antiretroviral-Naïve Human Immunodeficiency Virus-Infected Patients C. Herzmann, K. Arastèh, R. L. Murphy, H. Schulbin, P. Kreckel, D. Drauz, R. F. Schinazi, A. Beard, L. Cartee, and M. J. Otto Antimicrob. Agents Chemother. July 2005 49: 2828-2833; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Proteus mirabilis Bloodstream Infections: Risk Factors and Treatment Outcome Related to the Expression of Extended-Spectrum ß-Lactamases Andrea Endimiani, Francesco Luzzaro, Gioconda Brigante, Mariagrazia Perilli, Gianluigi Lombardi, Gianfranco Amicosante, Gian Maria Rossolini, and Antonio Toniolo Antimicrob. Agents Chemother. July 2005 49: 2598-2605; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Correlation between Ratio of Serum Doxycycline Concentration to MIC and Rapid Decline of Antibody Levels during Treatment of Q Fever Endocarditis Jean-Marc Rolain, Areen Boulos, Marie-Noëlle Mallet, and Didier Raoult Antimicrob. Agents Chemother. July 2005 49: 2673-2676; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Short-Course Gentamicin in Combination with Daptomycin or Vancomycin against Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations Brian T. Tsuji and Michael J. Rybak Antimicrob. Agents Chemother. July 2005 49: 2735-2745; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Imipenem for Treatment of Tuberculosis in Mice and Humans Henry F. Chambers, Joan Turner, Gisela F. Schecter, Masae Kawamura, and Philip C. Hopewell Antimicrob. Agents Chemother. July 2005 49: 2816-2821; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Volunteers Receiving Escherichia coli Phage T4 Orally: a Safety Test of Phage Therapy Anne Bruttin and Harald Brüssow Antimicrob. Agents Chemother. July 2005 49: 2874-2878; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Microplate Alamar Blue Assay for Staphylococcus epidermidis Biofilm Susceptibility Testing Robin K. Pettit, Christine A. Weber, Melissa J. Kean, Holger Hoffmann, George R. Pettit, Rui Tan, Kelly S. Franks, and Marilyn L. Horton Antimicrob. Agents Chemother. July 2005 49: 2612-2617; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activity of Novel Dendrimeric Peptides Obtained by Phage Display Selection and Rational Modification Alessandro Pini, Andrea Giuliani, Chiara Falciani, Ylenia Runci, Claudia Ricci, Barbara Lelli, Monica Malossi, Paolo Neri, Gian Maria Rossolini, and Luisa Bracci Antimicrob. Agents Chemother. July 2005 49: 2665-2672; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Structure of Enterococcus faecium Causing Bacteremia in a Spanish University Hospital: Setting the Scene for a Future Increase in Vancomycin Resistance? Teresa M. Coque, Rob J. L. Willems, Jesús Fortún, Janetta Top, Sergio Diz, Elena Loza, Rafael Cantón, and Fernando Baquero Antimicrob. Agents Chemother. July 2005 49: 2693-2700; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility of Streptococcus pneumoniae in Eight European Countries from 2001 to 2003 Ralf René Reinert, Susanne Reinert, Mark van der Linden, Murat Y. Cil, Adnan Al-Lahham, and Peter Appelbaum Antimicrob. Agents Chemother. July 2005 49: 2903-2913; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phage P68 Virion-Associated Protein 17 Displays Activity against Clinical Isolates of Staphylococcus aureus Marian Takác and Udo Bläsi Antimicrob. Agents Chemother. July 2005 49: 2934-2940; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Synergy of Ciprofloxacin and Gatifloxacin against Ciprofloxacin-Resistant Pseudomonas aeruginosa George A. Pankey and Deborah S. Ashcraft Antimicrob. Agents Chemother. July 2005 49: 2959-2964; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimalarial Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors Sunil Parikh, Jiri Gut, Eva Istvan, Daniel E. Goldberg, Diane V. Havlir, and Philip J. Rosenthal Antimicrob. Agents Chemother. July 2005 49: 2983-2985; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interactions of Micafungin with Other Antifungal Drugs against Clinical Isolates of Four Species of Cryptococcus Carolina Serena, Belkys Fernández-Torres, F. Javier Pastor, Luciana Trilles, Márcia dos Santos Lazéra, Nicole Nolard, and Josep Guarro Antimicrob. Agents Chemother. July 2005 49: 2994-2996; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimicrobial Susceptibility Testing of Helicobacter felis, H. bizzozeronii, and H. salomonis K. Van den Bulck, A. Decostere, I. Gruntar, M. Baele, B. Krt, R. Ducatelle, and F. Haesebrouck Antimicrob. Agents Chemother. July 2005 49: 2997-3000; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Time-Kill Study of the Activity of Telithromycin against Macrolide-Resistant Streptococcus pneumoniae Isolates with 23S rRNA Mutations and Changes in Ribosomal Proteins L4 and L22 Ralf René Reinert and Adnan Al-Lahham Antimicrob. Agents Chemother. July 2005 49: 3011-3013; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of KPC-Possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and Recommendations for Detection Simona Bratu, Mohamad Mooty, Satyen Nichani, David Landman, Carl Gullans, Barbara Pettinato, Usha Karumudi, Pooja Tolaney, and John Quale Antimicrob. Agents Chemother. July 2005 49: 3018-3020; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Progressive Increase in Antimicrobial Resistance among Invasive Isolates of Haemophilus influenzae Obtained from Children Admitted to a Hospital in Kilifi, Kenya, from 1994 to 2002 J. Anthony G. Scott, Salim Mwarumba, Caroline Ngetsa, Salome Njenga, Brett S. Lowe, Mary P. E. Slack, James A. Berkley, Isaiah Mwangi, Kathryn Maitland, Mike English, and Kevin Marsh Antimicrob. Agents Chemother. July 2005 49: 3021-3024; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of an Oral Streptogramin Antimicrobial, XRP2868, against Gram-Positive Bacteria G. M. Eliopoulos, M. J. Ferraro, C. B. Wennersten, and R. C. Moellering, Jr. Antimicrob. Agents Chemother. July 2005 49: 3034-3039; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antibacterial Activity of DX-619, a Novel Des-Fluoro(6) Quinolone Katsuko Fujikawa, Megumi Chiba, Mayumi Tanaka, and Kenichi Sato Antimicrob. Agents Chemother. July 2005 49: 3040-3045; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Levofloxacin and Comparable Agents against Middle Ear Fluid, Nasopharyngeal, and Oropharyngeal Pathogens Obtained from Costa Rican Children with Recurrent Otitis Media or Failing Other Antibiotic Therapy Carolina Soley, Adriano Arguedas, Wendy Porras, Silvia Guevara, Cecilia Loaiza, Alexandra Pérez, Guillermo Rincón, Malka Schultz, Jorge Arguedas, and Roberto Brilla Antimicrob. Agents Chemother. July 2005 49: 3056-3058; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Putative VanRS-Like Two-Component Regulatory System Associated with the Inducible Glycopeptide Resistance Cluster of Paenibacillus popilliae Henry Fraimow, Christopher Knob, Inmaculada A. Herrero, and Robin Patel Antimicrob. Agents Chemother. July 2005 49: 2625-2633; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alteration of Fatty Acid and Sterol Metabolism in Miltefosine-Resistant Leishmania donovani Promastigotes and Consequences for Drug-Membrane Interactions M. Rakotomanga, M. Saint-Pierre-Chazalet, and P. M. Loiseau Antimicrob. Agents Chemother. July 2005 49: 2677-2686; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Susceptibility of Staphylococcus aureus to Vancomycin and Platelet Microbicidal Protein Correlates with Defective Autolysis and Loss of Accessory Gene Regulator (agr) Function George Sakoulas, George M. Eliopoulos, Vance G. Fowler, Jr., Robert C. Moellering, Jr., Richard P. Novick, Natalie Lucindo, Michael R. Yeaman, and Arnold S. Bayer Antimicrob. Agents Chemother. July 2005 49: 2687-2692; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Gene Expression in Benznidazole-Resistant Trypanosoma cruzi Parasites Diana Villarreal, Philippe Nirdé, Mallorie Hide, Christian Barnabé, and Michel Tibayrenc Antimicrob. Agents Chemother. July 2005 49: 2701-2709; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New lnu(C) Gene Conferring Resistance to Lincomycin by Nucleotidylation in Streptococcus agalactiae UCN36 Adeline Achard, Corinne Villers, Vianney Pichereau, and Roland Leclercq Antimicrob. Agents Chemother. July 2005 49: 2716-2719; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Constitutive soxR Mutations Contribute to Multiple-Antibiotic Resistance in Clinical Escherichia coli Isolates Anastasia Koutsolioutsou, Samuel Peña-Llopis, and Bruce Demple Antimicrob. Agents Chemother. July 2005 49: 2746-2752; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Macrolide Resistance in Campylobacter jejuni and Campylobacter coli: Molecular Mechanism and Stability of the Resistance Phenotype Amera Gibreel, Veronica N. Kos, Monika Keelan, Cathy A. Trieber, Simon Levesque, Sophie Michaud, and Diane E. Taylor Antimicrob. Agents Chemother. July 2005 49: 2753-2759; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency Claude G. Lerner, Stephan J. Kakavas, Christian Wagner, Richard T. Chang, Philip J. Merta, Xiaoan Ruan, Randy E. Metzger, and Bruce A. Beutel Antimicrob. Agents Chemother. July 2005 49: 2767-2777; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structure-Based Phylogeny of the Metallo-ß-Lactamases Gianpiero Garau, Anne Marie Di Guilmi, and Barry G. Hall Antimicrob. Agents Chemother. July 2005 49: 2778-2784; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drug-Induced Regulation of the MDR1 Promoter in Candida albicans Jo Beth Harry, Brian G. Oliver, Jia L. Song, Peter M. Silver, John T. Little, Jake Choiniere, and Theodore C. White Antimicrob. Agents Chemother. July 2005 49: 2785-2792; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple-Antibiotic Resistance in Salmonella enterica Serotype Paratyphi B Isolates Collected in France between 2000 and 2003 Is Due Mainly to Strains Harboring Salmonella Genomic Islands 1, 1-B, and 1-C François-Xavier Weill, Laëtitia Fabre, Bernadette Grandry, Patrick A. D. Grimont, and Isabelle Casin Antimicrob. Agents Chemother. July 2005 49: 2793-2801; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sixteen Homologs of the Mex-Type Multidrug Resistance Efflux Pump in Bacteroides fragilis Ohmi Ueda, Hannah M. Wexler, Kaname Hirai, Yukinaga Shibata, Fuminobu Yoshimura, and Setsuo Fujimura Antimicrob. Agents Chemother. July 2005 49: 2807-2815; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Approach To Study the Relationship between Penicillin-Binding Protein 3 Mutations and Haemophilus influenzae ß-Lactam Resistance by Using Site-Directed Mutagenesis and Gene Recombinants Yumi Osaki, Yumiko Sanbongi, Midori Ishikawa, Hiroshi Kataoka, Takahisa Suzuki, Kumiko Maeda, and Takashi Ida Antimicrob. Agents Chemother. July 2005 49: 2834-2839; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amino Acid Substitution in Trichophyton rubrum Squalene Epoxidase Associated with Resistance to Terbinafine Colin S. Osborne, Ingrid Leitner, Bertrand Favre, and Neil S. Ryder Antimicrob. Agents Chemother. July 2005 49: 2840-2844; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cryptococcus neoformans Resistance to Echinocandins: (1,3)ß-Glucan Synthase Activity Is Sensitive to Echinocandins Marybeth A. Maligie and Claude P. Selitrennikoff Antimicrob. Agents Chemother. July 2005 49: 2851-2856; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Frequency of Spontaneous Mutations That Confer Antibiotic Resistance in Chlamydia spp. Rachel Binet and Anthony T. Maurelli Antimicrob. Agents Chemother. July 2005 49: 2865-2873; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Colonization and Resistance Dynamics of Gram-Negative Bacteria in Patients during and after Hospitalization P. Margreet G. Filius, Inge C. Gyssens, Irma M. Kershof, Patty J. E. Roovers, Alewijn Ott, Arnold G. Vulto, Henri A. Verbrugh, and Hubert P. Endtz Antimicrob. Agents Chemother. July 2005 49: 2879-2886; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identical Penicillin-Binding Domains in Penicillin-Binding Proteins of Streptococcus pneumoniae Clinical Isolates with Different Levels of ß-Lactam Resistance Laurent Chesnel, Raphaël Carapito, Jacques Croizé, Otto Dideberg, Thierry Vernet, and André Zapun Antimicrob. Agents Chemother. July 2005 49: 2895-2902; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of a New Line Probe Assay for Rapid Identification of gyrA Mutations in Mycobacterium tuberculosis Federico Giannoni, Elisabetta Iona, Federica Sementilli, Lara Brunori, Manuela Pardini, Giovanni Battista Migliori, Graziella Orefici, and Lanfranco Fattorini Antimicrob. Agents Chemother. July 2005 49: 2928-2933; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of a New Allelic Variant of the Acinetobacter baumannii Cephalosporinase, ADC-7 ß-Lactamase: Defining a Unique Family of Class C Enzymes Kristine M. Hujer, Nashaat S. Hamza, Andrea M. Hujer, Federico Perez, Marion S. Helfand, Christopher R. Bethel, Jodi M. Thomson, Vernon E. Anderson, Miriam Barlow, Louis B. Rice, Fred C. Tenover, and Robert A. Bonomo Antimicrob. Agents Chemother. July 2005 49: 2941-2948; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Worldwide Disseminated armA Aminoglycoside Resistance Methylase Gene Is Borne by Composite Transposon Tn1548 M. Galimand, S. Sabtcheva, P. Courvalin, and T. Lambert Antimicrob. Agents Chemother. July 2005 49: 2949-2953; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance to Imipenem and Ampicillin in Enterococcus faecalis Seiji Ono, Tetsuro Muratani, and Tetsuro Matsumoto Antimicrob. Agents Chemother. July 2005 49: 2954-2958; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structural and Functional Study of the Phenicol-Specific Efflux Pump FloR Belonging to the Major Facilitator Superfamily Martine Braibant, Jacqueline Chevalier, Elisabeth Chaslus-Dancla, Jean-Marie Pagès, and Axel Cloeckaert Antimicrob. Agents Chemother. July 2005 49: 2965-2971; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutagenesis Analysis of a Conserved Region Involved in Acetyl Coenzyme A Binding in the Aminoglycoside 6'-N-Acetyltransferase Type Ib Encoded by Plasmid pJHCMW1 Atousa Pourreza, Mavee Witherspoon, Jessica Fox, Jason Newmark, Duyen Bui, and Marcelo E. Tolmasky Antimicrob. Agents Chemother. July 2005 49: 2979-2982; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association between Resistance to Erythromycin and the Presence of the Fibronectin Binding Protein F1 Gene, prtF1, in Streptococcus pyogenes Isolates from German Pediatric Patients Maria Haller, Kirsten Fluegge, Sandra Jasminder Arri, Brit Adams, and Reinhard Berner Antimicrob. Agents Chemother. July 2005 49: 2990-2993; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Broader Distribution of Plasmid-Mediated Quinolone Resistance in the United States A. Robicsek, D. F. Sahm, J. Strahilevitz, G. A. Jacoby, and D. C. Hooper Antimicrob. Agents Chemother. July 2005 49: 3001-3003; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Compound Efflux in Helicobacter pylori Amy Kutschke and Boudewijn L. M. de Jonge Antimicrob. Agents Chemother. July 2005 49: 3009-3010; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transcriptional Analysis of the blaCTX-M-2 Gene in Salmonella enterica Serovar Infantis José A. Di Conza, Gabriel O. Gutkind, Marta E. Mollerach, and Juan A. Ayala Antimicrob. Agents Chemother. July 2005 49: 3014-3017; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Predominance of 23S rRNA Mutants among Non-Erm, Non-Mef Macrolide-Resistant Clinical Isolates of Streptococcus pneumoniae Collected in the United States in 1999-2000 Todd A. Davies, Karen Bush, Daniel Sahm, and Alan Evangelista Antimicrob. Agents Chemother. July 2005 49: 3031-3033; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Spectinomycin/Streptomycin Resistance Gene, aadA14, from Pasteurella multocida Corinna Kehrenberg, Boudewijn Catry, Freddy Haesebrouck, Aart de Kruif, and Stefan Schwarz Antimicrob. Agents Chemother. July 2005 49: 3046-3049; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction of the Plasmid-Encoded Quinolone Resistance Protein QnrA with Escherichia coli Topoisomerase IV John H. Tran, George A. Jacoby, and David C. Hooper Antimicrob. Agents Chemother. July 2005 49: 3050-3052; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Induction of Telithromycin Resistance by Erythromycin in Isolates of Macrolide-Resistant Staphylococcus spp. Kepler A. Davis, Sharon A. Crawford, Kristin R. Fiebelkorn, and James H. Jorgensen Antimicrob. Agents Chemother. July 2005 49: 3059-3061; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron-Associated Antibiotic Resistance and Phylogenetic Grouping of Escherichia coli Isolates from Healthy Subjects Free of Recent Antibiotic Exposure David Skurnik, Arnaud Le Menac'h, David Zurakowski, Didier Mazel, Patrice Courvalin, Erick Denamur, Antoine Andremont, and Raymond Ruimy Antimicrob. Agents Chemother. July 2005 49: 3062-3065; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Survey of Enterobacteriaceae Producing Extended-Spectrum ß-Lactamases in a Slovak Hospital: Dominance of SHV-2a and Characterization of TEM-132 Martina Zarnayová, Eliane Siebor, André Péchinot, Jean-Marie Duez, Helena Bujdáková, Roger Labia, and Catherine Neuwirth Antimicrob. Agents Chemother. July 2005 49: 3066-3069; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differences in the DNA Sequences in the Upstream Attenuator Region of erm(A) in Clinical Isolates of Streptococcus pyogenes and Their Correlation with Macrolide/Lincosamide Resistance Stella Z. Doktor and Virginia Shortridge Antimicrob. Agents Chemother. July 2005 49: 3070-3072; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of Glycopeptide-Resistant Enterococcus faecium Isolates from Portuguese Hospitals Carla Novais, João C. Sousa, Teresa M. Coque, Luísa V. Peixe, and The Portuguese Resistance Study Group Antimicrob. Agents Chemother. July 2005 49: 3073-3079; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Heterogeneity of Genotype-Phenotype Correlation among Macrolide-Resistant Streptococcus agalactiae Isolates Ulrich von Both, Anna Buerckstuemmer, Kirsten Fluegge, and Reinhard Berner Antimicrob. Agents Chemother. July 2005 49: 3080-3082; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association of Plasmid-Mediated Quinolone Resistance with Extended-Spectrum ß-Lactamase VEB-1 Laurent Poirel, Marc Van De Loo, Hedi Mammeri, and Patrice Nordmann Antimicrob. Agents Chemother. July 2005 49: 3091-3094; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Antistaphylococcal Effect Related to the Area under the Curve/MIC Ratio in an In Vitro Dynamic Model: Predicted Breakpoints versus Clinically Achievable Values for Seven Fluoroquinolones Alexander A. Firsov, Irene Y. Lubenko, Sergey N. Vostrov, Yury A. Portnoy, and Stephen H. Zinner Antimicrob. Agents Chemother. July 2005 49: 2642-2647; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of the Antiadhesin Octyl O-(2-Acetamido-2-Deoxy-ß-D- Galactopyranosyl)-(1-4)-2-O-Propyl-ß-D-Galactopyranoside (Fimbrigal-P) in a Rat Oral Candidiasis Model M. Foldvari, M. R. Jaafari, J. Radhi, and D. Segal Antimicrob. Agents Chemother. July 2005 49: 2887-2894; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Peptide Therapeutics for Cystic Fibrosis Lijuan Zhang, Jody Parente, Scott M. Harris, Donald E. Woods, Robert E. W. Hancock, and Timothy J. Falla Antimicrob. Agents Chemother. July 2005 49: 2921-2927; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Bactericidal Activities of Vancomycin Dispersed in Porous Biodegradable Poly(-Caprolactone) Microparticles Anne-Marie Le Ray, Hélène Gautier, Marie-Katel Laty, Guy Daculsi, Christian Merle, Cédric Jacqueline, Antoine Hamel, and Jocelyne Caillon Antimicrob. Agents Chemother. July 2005 49: 3025-3027; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Nebulized Liposomal Amphotericin B in Treatment of Experimental Pulmonary Aspergillosis Joan Gavaldà, María-Teresa Martín, Pedro López, Xavier Gomis, José-Luís Ramírez, Dolors Rodríguez, Oscar Len, Yolanda Puigfel, Isabel Ruíz, and Albert Pahissa Antimicrob. Agents Chemother. July 2005 49: 3028-3030; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Antibacterial Properties of Some Cyclic Organobismuth(III) Compounds Toshiaki Kotani, Daisuke Nagai, Kensuke Asahi, Hitomi Suzuki, Fumiaki Yamao, Nobumasa Kataoka, and Tatsuo Yagura Antimicrob. Agents Chemother. July 2005 49: 2729-2734; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Production of Enterocin P, an Antilisterial Pediocin-Like Bacteriocin from Enterococcus faecium P13, in Pichia pastoris Jorge Gutiérrez, Raquel Criado, María Martín, Carmen Herranz, Luis M. Cintas, and Pablo E. Hernández Antimicrob. Agents Chemother. July 2005 49: 3004-3008; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Population Pharmacokinetics of Cefepime in the Neonate Edmund Capparelli, Christine Hochwald, Maynard Rasmussen, Amy Parham, John Bradley, and Fernando Moya Antimicrob. Agents Chemother. July 2005 49: 2760-2766; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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The Macrolide Roxithromycin Impairs NADPH Oxidase Activation and Alters Translocation of Its Cytosolic Components to the Neutrophil Membrane In Vitro Houria Abdelghaffar, Catherine Babin-Chevaye, and Marie-Thérèse Labro Antimicrob. Agents Chemother. July 2005 49: 2986-2989; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevention of the Cryptic Epitope SLAYGLR within Osteopontin Does Not Influence Susceptibility to Candida albicans Infection Ikuko Sato, Nobuchika Yamamoto, Harumi Yamazaki, Seiji Hashimoto, Motohiro Hino, Fumihiko Sakai, and Akihiko Fujie Antimicrob. Agents Chemother. July 2005 49: 3053-3055; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Specific Antibodies, Levofloxacin, and Modulation of Capsule-Associated Virulence in Streptococcus pneumoniae David Tarragó, Noelia Lara, Asunción Fenoll, Julio Casal, María-José Giménez, Lorenzo Aguilar, and David Sevillano Antimicrob. Agents Chemother. July 2005 49: 3095-3096; [Full Text] [PDF] [Reprints and Permissions]

One New LEN Enzyme and Two New OKP Enzymes in Klebsiella pneumoniae Clinical Isolates and Proposed Nomenclature for Chromosomal ß-Lactamases of This Species Eliane Siebor, André Péchinot, Jean-Marie Duez, and Catherine Neuwirth Antimicrob. Agents Chemother. July 2005 49: 3097-3098; [Full Text] [PDF] [Reprints and Permissions]

Tet Protein Hybrids Stuart B. Levy, Laura M. McMurry, and Marilyn C. Roberts Antimicrob. Agents Chemother. July 2005 49: 3099 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Emergence of Macrolide-Resistant Mycoplasma pneumoniae with a 23S rRNA Gene Mutation Miyuki Morozumi, Keiko Hasegawa, Reiko Kobayashi, Nagako Inoue, Satoshi Iwata, Haruo Kuroki, Naohisa Kawamura, Eiichi Nakayama, Takeshi Tajima, Kouichi Shimizu, and Kimiko Ubukata Antimicrob. Agents Chemother. July 2005 49: 3100 [Full Text] [PDF] [Reprints and Permissions]

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