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Mechanisms of Resistance:

Florence Chapeland-Leclerc, Julien Bouchoux, Abdelhak Goumar, Christiane Chastin, Jean Villard, and Thierry Noël

Inactivation of the FCY2 Gene Encoding Purine-Cytosine Permease Promotes Cross-Resistance to Flucytosine and Fluconazole in Candida lusitaniae
Antimicrob. Agents Chemother. 2005 49: 3101-3108. [Abstract] [Full Text] [PDF]  

Charles R. Dean, Shubha Narayan, Denis M. Daigle, JoAnn L. Dzink-Fox, Xiaoling Puyang, Kathryn R. Bracken, Karl E. Dean, Beat Weidmann, Zhengyu Yuan, Rakesh Jain, and Neil S. Ryder

Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415
Antimicrob. Agents Chemother. 2005 49: 3129-3135. [Abstract] [Full Text] [PDF]  

Tawanda Gumbo, Arnold Louie, Mark R. Deziel, and George L. Drusano

Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance
Antimicrob. Agents Chemother. 2005 49: 3178-3181. [Abstract] [Full Text] [PDF]  

Courtney E. Maus, Bonnie B. Plikaytis, and Thomas M. Shinnick

Molecular Analysis of Cross-Resistance to Capreomycin, Kanamycin, Amikacin, and Viomycin in Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 2005 49: 3192-3197. [Abstract] [Full Text] [PDF]  

Claire Héritier, Laurent Poirel, Thierry Lambert, and Patrice Nordmann

Contribution of Acquired Carbapenem-Hydrolyzing Oxacillinases to Carbapenem Resistance in Acinetobacter baumannii
Antimicrob. Agents Chemother. 2005 49: 3198-3202. [Abstract] [Full Text] [PDF]  

S. Park, R. Kelly, J. Nielsen Kahn, J. Robles, M.-J. Hsu, E. Register, W. Li, V. Vyas, H. Fan, G. Abruzzo, A. Flattery, C. Gill, G. Chrebet, S. A. Parent, M. Kurtz, H. Teppler, C. M. Douglas, and D. S. Perlin

Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates
Antimicrob. Agents Chemother. 2005 49: 3264-3273. [Abstract] [Full Text] [PDF]  

Elisabetta Mantengoli and Gian Maria Rossolini

Tn5393d, a Complex Tn5393 Derivative Carrying the PER-1 Extended-Spectrum ß-Lactamase Gene and Other Resistance Determinants
Antimicrob. Agents Chemother. 2005 49: 3289-3296. [Abstract] [Full Text] [PDF]  

Beilei Ge, Patrick F. McDermott, David G. White, and Jianghong Meng

Role of Efflux Pumps and Topoisomerase Mutations in Fluoroquinolone Resistance in Campylobacter jejuni and Campylobacter coli
Antimicrob. Agents Chemother. 2005 49: 3347-3354. [Abstract] [Full Text] [PDF]  

María D. Maciá, David Blanquer, Bernat Togores, Jaume Sauleda, José L. Pérez, and Antonio Oliver

Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance in Pseudomonas aeruginosa Strains Causing Chronic Lung Infections
Antimicrob. Agents Chemother. 2005 49: 3382-3386. [Abstract] [Full Text] [PDF]  

Longzhu Cui, Jian-Qi Lian, Hui-min Neoh, Ethel Reyes, and Keiichi Hiramatsu

DNA Microarray-Based Identification of Genes Associated with Glycopeptide Resistance in Staphylococcus aureus
Antimicrob. Agents Chemother. 2005 49: 3404-3413. [Abstract] [Full Text] [PDF] [Supplemental material]  

Fahd K. Majiduddin and Timothy Palzkill

Amino Acid Residues That Contribute to Substrate Specificity of Class A ß-Lactamase SME-1
Antimicrob. Agents Chemother. 2005 49: 3421-3427. [Abstract] [Full Text] [PDF]  

Tulika Prasad, Preeti Saini, Naseem Akhtar Gaur, Ram A. Vishwakarma, Luqman Ahmad Khan, Qazi M. Rizwanul Haq, and Rajendra Prasad

Functional Analysis of CaIPT1, a Sphingolipid Biosynthetic Gene Involved in Multidrug Resistance and Morphogenesis of Candida albicans
Antimicrob. Agents Chemother. 2005 49: 3442-3452. [Abstract] [Full Text] [PDF]  

Cindy Fevre, Mehdi Jbel, Virginie Passet, François-Xavier Weill, Patrick A. D. Grimont, and Sylvain Brisse

Six Groups of the OXY ß-Lactamase Evolved over Millions of Years in Klebsiella oxytoca
Antimicrob. Agents Chemother. 2005 49: 3453-3462. [Abstract] [Full Text] [PDF]  

M. Teresa Tórtola, Susana Lavilla, Elisenda Miró, Juan José González, Nieves Larrosa, Montserrat Sabaté, Ferran Navarro, and Guillermo Prats

First Detection of a Carbapenem-Hydrolyzing Metalloenzyme in Two Enterobacteriaceae Isolates in Spain
Antimicrob. Agents Chemother. 2005 49: 3492-3494. [Abstract] [Full Text] [PDF]  

Philippe Cottagnoud, Maggie Johnson, Marianne Cottagnoud, and Laura Piddock

Preincubation of Pneumococci with ß-Lactams Alone or Combined with Levofloxacin Prevents Quinolone-Induced Resistance without Increasing Intracellular Levels of Levofloxacin
Antimicrob. Agents Chemother. 2005 49: 3517-3519. [Abstract] [Full Text] [PDF]  

Ralf René Reinert, Mark van der Linden, and Adnan Al-Lahham

Molecular Characterization of the First Telithromycin-Resistant Streptococcus pneumoniae Isolate in Germany
Antimicrob. Agents Chemother. 2005 49: 3520-3522. [Abstract] [Full Text] [PDF]  

Laurent Poirel, Jose-Manuel Rodriguez-Martinez, Hedi Mammeri, Alain Liard, and Patrice Nordmann

Origin of Plasmid-Mediated Quinolone Resistance Determinant QnrA
Antimicrob. Agents Chemother. 2005 49: 3523-3525. [Abstract] [Full Text] [PDF]  

Akemi Kojima, Yoshikazu Ishii, Kanako Ishihara, Hidetake Esaki, Tetsuo Asai, Chitose Oda, Yutaka Tamura, Toshio Takahashi, and Keizo Yamaguchi

Extended-Spectrum-ß-Lactamase-Producing Escherichia coli Strains Isolated from Farm Animals from 1999 to 2002: Report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program
Antimicrob. Agents Chemother. 2005 49: 3533-3537. [Abstract] [Full Text] [PDF]  

K. Lolans, A. M. Queenan, K. Bush, A. Sahud, and J. P. Quinn

First Nosocomial Outbreak of Pseudomonas aeruginosa Producing an Integron-Borne Metallo-ß-Lactamase (VIM-2) in the United States
Antimicrob. Agents Chemother. 2005 49: 3538-3540. [Abstract] [Full Text] [PDF]  

Vivi Miriagou, Alessandra Carattoli, Eva Tzelepi, Laura Villa, and Leonidas S. Tzouvelekis

IS26-Associated In4-Type Integrons Forming Multiresistance Loci in Enterobacterial Plasmids
Antimicrob. Agents Chemother. 2005 49: 3541-3543. [Abstract] [Full Text] [PDF]  

Nicole Wolter, Anthony M. Smith, David J. Farrell, William Schaffner, Matthew Moore, Cynthia G. Whitney, James H. Jorgensen, and Keith P. Klugman

Novel Mechanism of Resistance to Oxazolidinones, Macrolides, and Chloramphenicol in Ribosomal Protein L4 of the Pneumococcus
Antimicrob. Agents Chemother. 2005 49: 3554-3557. [Abstract] [Full Text] [PDF]  

Philippe Bidet, Béatrice Burghoffer, Valérie Gautier, Naïma Brahimi, Patricia Mariani-Kurkdjian, Alaa El-Ghoneimi, Edouard Bingen, and Guillaume Arlet

In Vivo Transfer of Plasmid-Encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an Infant and Selection of Impermeability to Imipenem in K. pneumoniae
Antimicrob. Agents Chemother. 2005 49: 3562-3565. [Abstract] [Full Text] [PDF]  

Miguel Viveiros, Ana Jesus, Mafalda Brito, Clara Leandro, Marta Martins, Diane Ordway, Ana Maria Molnar, Joseph Molnar, and Leonard Amaral

Inducement and Reversal of Tetracycline Resistance in Escherichia coli K-12 and Expression of Proton Gradient-Dependent Multidrug Efflux Pump Genes
Antimicrob. Agents Chemother. 2005 49: 3578-3582. [Abstract] [Full Text] [PDF]  

Kwan Soo Ko, Yeon-Sook Kim, Jae-Hoon Song, Joon-Sup Yeom, Hyuck Lee, Sook-In Jung, Doo-Ryun Jeong, Shin-Woo Kim, Hyun-Ha Chang, Hyun Kyun Ki, Chisook Moon, Won Sup Oh, Kyong Ran Peck, and Nam Yong Lee

Genotypic Diversity of Methicillin-Resistant Staphylococcus aureus Isolates in Korean Hospitals
Antimicrob. Agents Chemother. 2005 49: 3583-3585. [Abstract] [Full Text] [PDF]  

Gabriela Novotna, Václava Adamkova, Jiri Janata, Oto Melter, and Jaroslav Spizek

Prevalence of Resistance Mechanisms against Macrolides and Lincosamides in Methicillin-Resistant Coagulase-Negative Staphylococci in the Czech Republic and Occurrence of an Undefined Mechanism of Resistance to Lincosamides
Antimicrob. Agents Chemother. 2005 49: 3586-3589. [Abstract] [Full Text] [PDF]  

Daniel Aubert, Thierry Naas, Marie-Frédérique Lartigue, and Patrice Nordmann

Novel Genetic Structure Associated with an Extended-Spectrum ß-Lactamase bla_VEB Gene in a Providencia stuartii Clinical Isolate from Algeria
Antimicrob. Agents Chemother. 2005 49: 3590-3592. [Abstract] [Full Text] [PDF]  

Laurent Poirel, Laura Brinas, Nicolas Fortineau, and Patrice Nordmann

Integron-Encoded GES-Type Extended-Spectrum ß-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2005 49: 3593-3597. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Eric Brouillette, Mamoru Hyodo, Yoshihiro Hayakawa, David K. R. Karaolis, and François Malouin

3',5'-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection
Antimicrob. Agents Chemother. 2005 49: 3109-3113. [Abstract] [Full Text] [PDF]  

Sofia K. Kasiakou, Argyris Michalopoulos, Elpidoforos S. Soteriades, George Samonis, George J. Sermaides, and Matthew E. Falagas

Combination Therapy with Intravenous Colistin for Management of Infections Due to Multidrug-Resistant Gram-Negative Bacteria in Patients without Cystic Fibrosis
Antimicrob. Agents Chemother. 2005 49: 3136-3146. [Abstract] [Full Text] [PDF]  

Nimol Khim, Christiane Bouchier, Marie-Thérèse Ekala, Sandra Incardona, Pharath Lim, Eric Legrand, Ronan Jambou, Socheat Doung, Odile Mercereau Puijalon, and Thierry Fandeur

Countrywide Survey Shows Very High Prevalence of Plasmodium falciparum Multilocus Resistance Genotypes in Cambodia
Antimicrob. Agents Chemother. 2005 49: 3147-3152. [Abstract] [Full Text] [PDF]  

Andres G. Madrigal, Li Basuino, and Henry F. Chambers

Efficacy of Telavancin in a Rabbit Model of Aortic Valve Endocarditis Due to Methicillin-Resistant Staphylococcus aureus or Vancomycin-Intermediate Staphylococcus aureus
Antimicrob. Agents Chemother. 2005 49: 3163-3165. [Abstract] [Full Text] [PDF]  

Mark S. Rouse, Margalida Rotger, Kerryl E. Piper, James M. Steckelberg, Matthew Scholz, Jeffrey Andrews, and Robin Patel

In Vitro and In Vivo Evaluations of the Activities of Lauric Acid Monoester Formulations against Staphylococcus aureus
Antimicrob. Agents Chemother. 2005 49: 3187-3191. [Abstract] [Full Text] [PDF]  

Xin-Xing Tan, Jeffrey K. Actor, and Yin Chen

Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection
Antimicrob. Agents Chemother. 2005 49: 3203-3207. [Abstract] [Full Text] [PDF]  

Hamdan I. Al-Mohammed, Michael L. Chance, and Paul A. Bates

Production and Characterization of Stable Amphotericin-Resistant Amastigotes and Promastigotes of Leishmania mexicana
Antimicrob. Agents Chemother. 2005 49: 3274-3280. [Abstract] [Full Text] [PDF]  

Véronique Dartois, Jorge Sanchez-Quesada, Edelmira Cabezas, Ellen Chi, Chad Dubbelde, Carrie Dunn, Juan Granja, Colleen Gritzen, Dana Weinberger, M. Reza Ghadiri, and Thomas R. Parr, Jr.

Systemic Antibacterial Activity of Novel Synthetic Cyclic Peptides
Antimicrob. Agents Chemother. 2005 49: 3302-3310. [Abstract] [Full Text] [PDF]  

Cristina Pichardo, José Manuel Rodríguez-Martínez, María E. Pachón-Ibañez, Carmen Conejo, José Ibáñez-Martínez, Luis Martínez-Martínez, Jerónimo Pachón, and Álvaro Pascual

Efficacy of Cefepime and Imipenem in Experimental Murine Pneumonia Caused by Porin-Deficient Klebsiella pneumoniae Producing CMY-2 ß-Lactamase
Antimicrob. Agents Chemother. 2005 49: 3311-3316. [Abstract] [Full Text] [PDF]  

Elisabeth Kugelberg, Tobias Norström, Thomas K. Petersen, Tore Duvold, Dan I. Andersson, and Diarmaid Hughes

Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes
Antimicrob. Agents Chemother. 2005 49: 3435-3441. [Abstract] [Full Text] [PDF]  

Ernest J. Mui, David Jacobus, Wilbur K. Milhous, Guy Schiehser, Honghue Hsu, Craig W. Roberts, Michael J. Kirisits, and Rima McLeod

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo
Antimicrob. Agents Chemother. 2005 49: 3463-3467. [Abstract] [Full Text] [PDF]  

Nicole J. Pultz, Usha Stiefel, and Curtis J. Donskey

Effects of Daptomycin, Linezolid, and Vancomycin on Establishment of Intestinal Colonization with Vancomycin-Resistant Enterococci and Extended-Spectrum-ß-Lactamase-Producing Klebsiella pneumoniae in Mice
Antimicrob. Agents Chemother. 2005 49: 3513-3516. [Abstract] [Full Text] [PDF]  

Jun Nagura, Koji Kijima, Mizuyo Kurazono, Sho Takahata, Toshie Sugano, Yukari Tanaka, Yoko Hirai, Keiko Yamada, Yoshihiro Takayama, Eiki Shitara, and Minoru Yonezawa

Therapeutic Effect of ME1036 on Endocarditis Experimentally Induced by Methicillin-Resistant Staphylococcus aureus
Antimicrob. Agents Chemother. 2005 49: 3526-3528. [Abstract] [Full Text] [PDF]  

Nicole J. Pultz and Curtis J. Donskey

Effect of Antibiotic Treatment on Growth of and Toxin Production by Clostridium difficile in the Cecal Contents of Mice
Antimicrob. Agents Chemother. 2005 49: 3529-3532. [Abstract] [Full Text] [PDF]  

Mechanisms of Action:

Yan Q. Xiong, Kasturi Mukhopadhyay, Michael R. Yeaman, Jill Adler-Moore, and Arnold S. Bayer

Functional Interrelationships between Cell Membrane and Cell Wall in Antimicrobial Peptide-Mediated Killing of Staphylococcus aureus
Antimicrob. Agents Chemother. 2005 49: 3114-3121. [Abstract] [Full Text] [PDF]  

Haim Tsubery, Hertzig Yaakov, Sofia Cohen, Tal Giterman, Ariella Matityahou, Mati Fridkin, and Itzhak Ofek

Neopeptide Antibiotics That Function as Opsonins and Membrane-Permeabilizing Agents for Gram-Negative Bacteria
Antimicrob. Agents Chemother. 2005 49: 3122-3128. [Abstract] [Full Text] [PDF]  

Berthony Deslouches, Kazi Islam, Jodi K. Craigo, Shruti M. Paranjape, Ronald C. Montelaro, and Timothy A. Mietzner

Activity of the De Novo Engineered Antimicrobial Peptide WLBU2 against Pseudomonas aeruginosa in Human Serum and Whole Blood: Implications for Systemic Applications
Antimicrob. Agents Chemother. 2005 49: 3208-3216. [Abstract] [Full Text] [PDF]  

Michelle D. Brazas and Robert E. W. Hancock

Ciprofloxacin Induction of a Susceptibility Determinant in Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2005 49: 3222-3227. [Abstract] [Full Text] [PDF] [Supplemental material]  

Hideo Kohka Takahashi, Hiromi Iwagaki, Dong Xue, Goutarou Katsuno, Sachi Sugita, Kenji Mizuno, Shuji Mori, Shinya Saito, Tadashi Yoshino, Noriaki Tanaka, and Masahiro Nishibori

Effect of Ciprofloxacin-Induced Prostaglandin E₂ on Interleukin-18-Treated Monocytes
Antimicrob. Agents Chemother. 2005 49: 3228-3233. [Abstract] [Full Text] [PDF]  

Olga Senkovich, Vandanajay Bhatia, Nisha Garg, and Debasish Chattopadhyay

Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi: Prospect for Chemotherapy of Chagas' Disease
Antimicrob. Agents Chemother. 2005 49: 3234-3238. [Abstract] [Full Text] [PDF]  

Alexander Mathis, Peter Wild, Erik C. Boettger, Christian M. O. Kapel, and Peter Deplazes

Mitochondrial Ribosome as the Target for the Macrolide Antibiotic Clarithromycin in the Helminth Echinococcus multilocularis
Antimicrob. Agents Chemother. 2005 49: 3251-3255. [Abstract] [Full Text] [PDF]  

Ewa Oldak and Elzbieta A. Trafny

Secretion of Proteases by Pseudomonas aeruginosa Biofilms Exposed to Ciprofloxacin
Antimicrob. Agents Chemother. 2005 49: 3281-3288. [Abstract] [Full Text] [PDF]  

D. T. A. te Dorsthorst, P. E. Verweij, J. F. G. M. Meis, and J. W. Mouton

Relationship between In Vitro Activities of Amphotericin B and Flucytosine and pH for Clinical Yeast and Mold Isolates
Antimicrob. Agents Chemother. 2005 49: 3341-3346. [Abstract] [Full Text] [PDF]  

Howard N. Hunter, A. Ross Demcoe, Håvard Jenssen, Tore J. Gutteberg, and Hans J. Vogel

Human Lactoferricin Is Partially Folded in Aqueous Solution and Is Better Stabilized in a Membrane Mimetic Solvent
Antimicrob. Agents Chemother. 2005 49: 3387-3395. [Abstract] [Full Text] [PDF]  

Hidenori Matsui, Masahiro Eguchi, Katsufumi Ohsumi, Akio Nakamura, Yasunori Isshiki, Kachiko Sekiya, Yuji Kikuchi, Tohru Nagamitsu, Rokuro Masuma, Toshiaki Sunazuka, and Satoshi Omura

Azithromycin Inhibits the Formation of Flagellar Filaments without Suppressing Flagellin Synthesis in Salmonella enterica Serovar Typhimurium
Antimicrob. Agents Chemother. 2005 49: 3396-3403. [Abstract] [Full Text] [PDF]  

Emmanuelle Laffly, Ludivine Danjou, Florence Condemine, Dominique Vidal, Emmanuel Drouet, Marie-Paule Lefranc, Chantal Bottex, and Philippe Thullier

Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694
Antimicrob. Agents Chemother. 2005 49: 3414-3420. [Abstract] [Full Text] [PDF]  

Kenneth D. Greis, Songtao Zhou, Richard Siehnel, Chuck Klanke, Alan Curnow, Jeremy Howard, and Gerlinde Layh-Schmitt

Development and Validation of a Whole-Cell Inhibition Assay for Bacterial Methionine Aminopeptidase by Surface-Enhanced Laser Desorption Ionization-Time of Flight Mass Spectrometry
Antimicrob. Agents Chemother. 2005 49: 3428-3434. [Abstract] [Full Text] [PDF]  

Guofei Dai, Ni Cheng, Lei Dong, Mutsumi Muramatsu, Shudong Xiao, Ming-Wei Wang, and De-Xu Zhu

Bactericidal and Morphological Effects of NE-2001, a Novel Synthetic Agent Directed against Helicobacter pylori
Antimicrob. Agents Chemother. 2005 49: 3468-3473. [Abstract] [Full Text] [PDF]  

Raymund R. Razonable, Martin Henault, Harold L. Watson, and Carlos V. Paya

Nystatin Induces Secretion of Interleukin (IL)-1ß, IL-8, and Tumor Necrosis Factor Alpha by a Toll-Like Receptor-Dependent Mechanism
Antimicrob. Agents Chemother. 2005 49: 3546-3549. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Wendy C. Magee, Karl Y. Hostetler, and David H. Evans

Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate
Antimicrob. Agents Chemother. 2005 49: 3153-3162. [Abstract] [Full Text] [PDF]  

Michael J. Moser, Meta Ruckstuhl, Christine A. Larsen, Amanda J. Swearingen, Miroslaw Kozlowski, Leda Bassit, Prem L. Sharma, Raymond F. Schinazi, and James R. Prudent

Quantifying Mixed Populations of Drug-Resistant Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2005 49: 3334-3340. [Abstract] [Full Text] [PDF]  

Takao Nitanda, Xin Wang, Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Yung-Chi Cheng, and Masanori Baba

Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2',3'-Didehydro-3'-Deoxy-4'-Ethynylthymidine In Vitro
Antimicrob. Agents Chemother. 2005 49: 3355-3360. [Abstract] [Full Text] [PDF]  

Gene D. Morse, Susan Rosenkranz, Michael F. Para, Yoninah Segal, Robin DiFrancesco, Elizabeth Adams, Barbara Brizz, Kevin E. Yarasheski, Richard C. Reichman the ACTG 5043 Protocol Team

Amprenavir and Efavirenz Pharmacokinetics before and after the Addition of Nelfinavir, Indinavir, Ritonavir, or Saquinavir in Seronegative Individuals
Antimicrob. Agents Chemother. 2005 49: 3373-3381. [Abstract] [Full Text] [PDF]  

Katsunori Takashima, Hiroshi Miyake, Naoyuki Kanzaki, Yoshihiko Tagawa, Xin Wang, Yoshihiro Sugihara, Yuji Iizawa, and Masanori Baba

Highly Potent Inhibition of Human Immunodeficiency Virus Type 1 Replication by TAK-220, an Orally Bioavailable Small-Molecule CCR5 Antagonist
Antimicrob. Agents Chemother. 2005 49: 3474-3482. [Abstract] [Full Text] [PDF]  

Cécile L. Tremblay, Françoise Giguel, Yongbiao Guan, Ting-Chao Chou, Katsunori Takashima, and Martin S. Hirsch

TAK-220, a Novel Small-Molecule CCR5 Antagonist, Has Favorable Anti-Human Immunodeficiency Virus Interactions with Other Antiretrovirals In Vitro
Antimicrob. Agents Chemother. 2005 49: 3483-3485. [Abstract] [Full Text] [PDF]  

Susceptibility:

Erik Glocker, Marco Berning, Monique M. Gerrits, Johannes G. Kusters, and Manfred Kist

Real-Time PCR Screening for 16S rRNA Mutations Associated with Resistance to Tetracycline in Helicobacter pylori
Antimicrob. Agents Chemother. 2005 49: 3166-3170. [Abstract] [Full Text] [PDF]  

Tetsufumi Koga, Tomomi Abe, Harumi Inoue, Takashi Takenouchi, Akiko Kitayama, Tatsuhiko Yoshida, Nobuhisa Masuda, Chika Sugihara, Masayo Kakuta, Miyuki Nakagawa, Takahiro Shibayama, Yoko Matsushita, Takashi Hirota, Satoshi Ohya, Yukio Utsui, Takashi Fukuoka, and Syogo Kuwahara

In Vitro and In Vivo Antibacterial Activities of CS-023 (RO4908463), a Novel Parenteral Carbapenem
Antimicrob. Agents Chemother. 2005 49: 3239-3250. [Abstract] [Full Text] [PDF]  

Caroline M. Kusuma and John F. Kokai-Kun

Comparison of Four Methods for Determining Lysostaphin Susceptibility of Various Strains of Staphylococcus aureus
Antimicrob. Agents Chemother. 2005 49: 3256-3263. [Abstract] [Full Text] [PDF]  

Robert A. Larsen, Madeline Bauer, Ann M. Thomas, Alejandro Sanchez, Diane Citron, Meri Rathbun, and Thomas S. Harrison

Correspondence of In Vitro and In Vivo Fluconazole Dose-Response Curves for Cryptococcus neoformans
Antimicrob. Agents Chemother. 2005 49: 3297-3301. [Abstract] [Full Text] [PDF]  

Tatiana Bogdanovich, Duygu Esel, Linda M. Kelly, Bülent Bozdogan, Kim Credito, Gengrong Lin, Kathy Smith, Lois M. Ednie, Dianne B. Hoellman, and Peter C. Appelbaum

Antistaphylococcal Activity of DX-619, a New Des-F(6)-Quinolone, Compared to Those of Other Agents
Antimicrob. Agents Chemother. 2005 49: 3325-3333. [Abstract] [Full Text] [PDF]  

L. Majoros, G. Kardos, B. Szabó, and M. Sipiczki

Caspofungin Susceptibility Testing of Candida inconspicua: Correlation of Different Methods with the Minimal Fungicidal Concentration
Antimicrob. Agents Chemother. 2005 49: 3486-3488. [Abstract] [Full Text] [PDF]  

Dong-Min Kim, Yong Lym, Sook Jin Jang, Hulin Han, Young Gi Kim, Choon-Hae Chung, and Soon Pyo Hong

In Vitro Efficacy of the Combination of Ciprofloxacin and Cefotaxime against Vibrio vulnificus
Antimicrob. Agents Chemother. 2005 49: 3489-3491. [Abstract] [Full Text] [PDF]  

J. Guinea, T. Peláez, L. Alcalá, M. J. Ruiz-Serrano, and E. Bouza

Antifungal Susceptibility of 596 Aspergillus fumigatus Strains Isolated from Outdoor Air, Hospital Air, and Clinical Samples: Analysis by Site of Isolation
Antimicrob. Agents Chemother. 2005 49: 3495-3497. [Abstract] [Full Text] [PDF]  

Clara Yustes and Josep Guarro

In Vitro Synergistic Interaction between Amphotericin B and Micafungin against Scedosporium spp.
Antimicrob. Agents Chemother. 2005 49: 3498-3500. [Abstract] [Full Text] [PDF]  

Helio S. Sader, Thomas R. Fritsche, Koné Kaniga, Yigong Ge, and Ronald N. Jones

Antimicrobial Activity and Spectrum of PPI-0903M (T-91825), a Novel Cephalosporin, Tested against a Worldwide Collection of Clinical Strains
Antimicrob. Agents Chemother. 2005 49: 3501-3512. [Abstract] [Full Text] [PDF]  

E. R. Oliveira, A. W. Fothergill, W. R. Kirkpatrick, B. J. Coco, T. F. Patterson, and S. W. Redding

In Vitro Interaction of Posaconazole and Caspofungin against Clinical Isolates of Candida glabrata
Antimicrob. Agents Chemother. 2005 49: 3544-3545. [Abstract] [Full Text] [PDF]  

Annie Philip, Zekaver Odabasi, Jose Rodriguez, Victor L. Paetznick, Enuo Chen, John H. Rex, and Luis Ostrosky-Zeichner

In Vitro Synergy Testing of Anidulafungin with Itraconazole, Voriconazole, and Amphotericin B against Aspergillus spp. and Fusarium spp.
Antimicrob. Agents Chemother. 2005 49: 3572-3574. [Abstract] [Full Text] [PDF]  

Harald Noedl, Jan Bronnert, Kritsanai Yingyuen, Bernhard Attlmayr, Herwig Kollaritsch, and Mark Fukuda

Simple Histidine-Rich Protein 2 Double-Site Sandwich Enzyme-Linked Immunosorbent Assay for Use in Malaria Drug Sensitivity Testing
Antimicrob. Agents Chemother. 2005 49: 3575-3577. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

Cornelius J. Clancy, Victor L. Yu, Arthur J. Morris, David R. Snydman, and M. Hong Nguyen

Fluconazole MIC and the Fluconazole Dose/MIC Ratio Correlate with Therapeutic Response among Patients with Candidemia
Antimicrob. Agents Chemother. 2005 49: 3171-3177. [Abstract] [Full Text] [PDF]  

S. Etuaful, B. Carbonnelle, J. Grosset, S. Lucas, C. Horsfield, R. Phillips, M. Evans, D. Ofori-Adjei, E. Klustse, J. Owusu-Boateng, G. K. Amedofu, P. Awuah, E. Ampadu, G. Amofah, K. Asiedu, and M. Wansbrough-Jones

Efficacy of the Combination Rifampin-Streptomycin in Preventing Growth of Mycobacterium ulcerans in Early Lesions of Buruli Ulcer in Humans
Antimicrob. Agents Chemother. 2005 49: 3182-3186. [Abstract] [Full Text] [PDF]  

Mark J. DiNubile, Joseph W. Chow, Vilas Satishchandran, Adam Polis, Mary R. Motyl, Murray A. Abramson, and Hedy Teppler

Acquisition of Resistant Bowel Flora during a Double-Blind Randomized Clinical Trial of Ertapenem versus Piperacillin-Tazobactam Therapy for Intraabdominal Infections
Antimicrob. Agents Chemother. 2005 49: 3217-3221. [Abstract] [Full Text] [PDF]  

Nita L. Seibel, Cindy Schwartz, Antonio Arrieta, Patricia Flynn, Aziza Shad, Edith Albano, James Keirns, Wendi M. Lau, David P. Facklam, Donald N. Buell, and Thomas J. Walsh

Safety, Tolerability, and Pharmacokinetics of Micafungin (FK463) in Febrile Neutropenic Pediatric Patients
Antimicrob. Agents Chemother. 2005 49: 3317-3324. [Abstract] [Full Text] [PDF]  

Patrick F. Smith, Gregory K. Robbins, Robert W. Shafer, Hulin Wu, Song Yu, Martin S. Hirsch, Thomas C. Merigan, Jeong-Gun Park, Alan Forrest, Margaret A. Fischl, Gene D. Morse, and the ACTG 384-5006 Team

Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naïve, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors
Antimicrob. Agents Chemother. 2005 49: 3558-3561. [Abstract] [Full Text] [PDF]  

Arthur Leibovitz, Yehuda Carmeli, and Refael Segal

Effect of Various Antibacterial Preparations on the Pathogenic Oral Flora in Elderly Patients Fed via Nasogastric Tube
Antimicrob. Agents Chemother. 2005 49: 3566-3568. [Abstract] [Full Text] [PDF]  

Pharmacology:

Vincent Jullien, Jean-Marc Tréluyer, Elisabeth Rey, Patrick Jaffray, Anne Krivine, Laurence Moachon, Agnès Lillo-Le Louet, Anne Lescoat, Nicolas Dupin, Dominique Salmon, Gérard Pons, and Saïk Urien

Population Pharmacokinetics of Tenofovir in Human Immunodeficiency Virus-Infected Patients Taking Highly Active Antiretroviral Therapy
Antimicrob. Agents Chemother. 2005 49: 3361-3366. [Abstract] [Full Text] [PDF]  

Federico Pea, Pierluigi Viale, Daniela Damiani, Federica Pavan, Francesco Cristini, Renato Fanin, and Mario Furlanut

Ceftazidime in Acute Myeloid Leukemia Patients with Febrile Neutropenia: Helpfulness of Continuous Intravenous Infusion in Maximizing Pharmacodynamic Exposure
Antimicrob. Agents Chemother. 2005 49: 3550-3553. [Abstract] [Full Text] [PDF]  

Analytical Procedures:

Kang Yan, Eric Hunt, John Berge, Earl May, Robert A. Copeland, and Richard R. Gontarek

Fluorescence Polarization Method To Characterize Macrolide-Ribosome Interactions
Antimicrob. Agents Chemother. 2005 49: 3367-3372. [Abstract] [Full Text] [PDF]  

GholamAli Khoschsorur, Franz Fruehwirth, and Sieglinde Zelzer

Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum
Antimicrob. Agents Chemother. 2005 49: 3569-3571. [Abstract] [Full Text] [PDF]  

Letters:

M. Wootton, P. M. Bennett, A. P. MacGowan, and T. R. Walsh

Strain-Specific Expression Levels of pbp4 Exist in Isolates of Glycopeptide-Intermediate Staphylococcus aureus (GISA) and Heterogeneous GISA
Antimicrob. Agents Chemother. 2005 49: 3598-3599. [Full Text] [PDF]  

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