AAC -- Table of Contents (August 1 2005, 49 [8])

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Contents: August 2005, Volume 49, Issue 8

       Mechanisms of Resistance

       Experimental Therapeutics

       Mechanisms of Action

       Antiviral Agents

       Susceptibility

       Clinical Therapeutics

       Pharmacology

       Analytical Procedures

       Letters

Other Issues

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Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Mechanisms of Resistance:

Inactivation of the FCY2 Gene Encoding Purine-Cytosine Permease Promotes Cross-Resistance to Flucytosine and Fluconazole in Candida lusitaniae
Florence Chapeland-Leclerc, Julien Bouchoux, Abdelhak Goumar, Christiane Chastin, Jean Villard, and Thierry Noël
Antimicrob. Agents Chemother. August 2005 49: 3101-3108;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415
Charles R. Dean, Shubha Narayan, Denis M. Daigle, JoAnn L. Dzink-Fox, Xiaoling Puyang, Kathryn R. Bracken, Karl E. Dean, Beat Weidmann, Zhengyu Yuan, Rakesh Jain, and Neil S. Ryder
Antimicrob. Agents Chemother. August 2005 49: 3129-3135;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance
Tawanda Gumbo, Arnold Louie, Mark R. Deziel, and George L. Drusano
Antimicrob. Agents Chemother. August 2005 49: 3178-3181;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Analysis of Cross-Resistance to Capreomycin, Kanamycin, Amikacin, and Viomycin in Mycobacterium tuberculosis
Courtney E. Maus, Bonnie B. Plikaytis, and Thomas M. Shinnick
Antimicrob. Agents Chemother. August 2005 49: 3192-3197;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of Acquired Carbapenem-Hydrolyzing Oxacillinases to Carbapenem Resistance in Acinetobacter baumannii
Claire Héritier, Laurent Poirel, Thierry Lambert, and Patrice Nordmann
Antimicrob. Agents Chemother. August 2005 49: 3198-3202;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates
S. Park, R. Kelly, J. Nielsen Kahn, J. Robles, M.-J. Hsu, E. Register, W. Li, V. Vyas, H. Fan, G. Abruzzo, A. Flattery, C. Gill, G. Chrebet, S. A. Parent, M. Kurtz, H. Teppler, C. M. Douglas, and D. S. Perlin
Antimicrob. Agents Chemother. August 2005 49: 3264-3273;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tn5393d, a Complex Tn5393 Derivative Carrying the PER-1 Extended-Spectrum ß-Lactamase Gene and Other Resistance Determinants
Elisabetta Mantengoli and Gian Maria Rossolini
Antimicrob. Agents Chemother. August 2005 49: 3289-3296;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Efflux Pumps and Topoisomerase Mutations in Fluoroquinolone Resistance in Campylobacter jejuni and Campylobacter coli
Beilei Ge, Patrick F. McDermott, David G. White, and Jianghong Meng
Antimicrob. Agents Chemother. August 2005 49: 3347-3354;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance in Pseudomonas aeruginosa Strains Causing Chronic Lung Infections
María D. Maciá, David Blanquer, Bernat Togores, Jaume Sauleda, José L. Pérez, and Antonio Oliver
Antimicrob. Agents Chemother. August 2005 49: 3382-3386;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

DNA Microarray-Based Identification of Genes Associated with Glycopeptide Resistance in Staphylococcus aureus
Longzhu Cui, Jian-Qi Lian, Hui-min Neoh, Ethel Reyes, and Keiichi Hiramatsu
Antimicrob. Agents Chemother. August 2005 49: 3404-3413;
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Amino Acid Residues That Contribute to Substrate Specificity of Class A ß-Lactamase SME-1
Fahd K. Majiduddin and Timothy Palzkill
Antimicrob. Agents Chemother. August 2005 49: 3421-3427;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Analysis of CaIPT1, a Sphingolipid Biosynthetic Gene Involved in Multidrug Resistance and Morphogenesis of Candida albicans
Tulika Prasad, Preeti Saini, Naseem Akhtar Gaur, Ram A. Vishwakarma, Luqman Ahmad Khan, Qazi M. Rizwanul Haq, and Rajendra Prasad
Antimicrob. Agents Chemother. August 2005 49: 3442-3452;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Six Groups of the OXY ß-Lactamase Evolved over Millions of Years in Klebsiella oxytoca
Cindy Fevre, Mehdi Jbel, Virginie Passet, François-Xavier Weill, Patrick A. D. Grimont, and Sylvain Brisse
Antimicrob. Agents Chemother. August 2005 49: 3453-3462;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Detection of a Carbapenem-Hydrolyzing Metalloenzyme in Two Enterobacteriaceae Isolates in Spain
M. Teresa Tórtola, Susana Lavilla, Elisenda Miró, Juan José González, Nieves Larrosa, Montserrat Sabaté, Ferran Navarro, and Guillermo Prats
Antimicrob. Agents Chemother. August 2005 49: 3492-3494;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Preincubation of Pneumococci with ß-Lactams Alone or Combined with Levofloxacin Prevents Quinolone-Induced Resistance without Increasing Intracellular Levels of Levofloxacin
Philippe Cottagnoud, Maggie Johnson, Marianne Cottagnoud, and Laura Piddock
Antimicrob. Agents Chemother. August 2005 49: 3517-3519;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of the First Telithromycin-Resistant Streptococcus pneumoniae Isolate in Germany
Ralf René Reinert, Mark van der Linden, and Adnan Al-Lahham
Antimicrob. Agents Chemother. August 2005 49: 3520-3522;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Origin of Plasmid-Mediated Quinolone Resistance Determinant QnrA
Laurent Poirel, Jose-Manuel Rodriguez-Martinez, Hedi Mammeri, Alain Liard, and Patrice Nordmann
Antimicrob. Agents Chemother. August 2005 49: 3523-3525;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum-ß-Lactamase-Producing Escherichia coli Strains Isolated from Farm Animals from 1999 to 2002: Report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program
Akemi Kojima, Yoshikazu Ishii, Kanako Ishihara, Hidetake Esaki, Tetsuo Asai, Chitose Oda, Yutaka Tamura, Toshio Takahashi, and Keizo Yamaguchi
Antimicrob. Agents Chemother. August 2005 49: 3533-3537;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Nosocomial Outbreak of Pseudomonas aeruginosa Producing an Integron-Borne Metallo-ß-Lactamase (VIM-2) in the United States
K. Lolans, A. M. Queenan, K. Bush, A. Sahud, and J. P. Quinn
Antimicrob. Agents Chemother. August 2005 49: 3538-3540;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

IS26-Associated In4-Type Integrons Forming Multiresistance Loci in Enterobacterial Plasmids
Vivi Miriagou, Alessandra Carattoli, Eva Tzelepi, Laura Villa, and Leonidas S. Tzouvelekis
Antimicrob. Agents Chemother. August 2005 49: 3541-3543;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Mechanism of Resistance to Oxazolidinones, Macrolides, and Chloramphenicol in Ribosomal Protein L4 of the Pneumococcus
Nicole Wolter, Anthony M. Smith, David J. Farrell, William Schaffner, Matthew Moore, Cynthia G. Whitney, James H. Jorgensen, and Keith P. Klugman
Antimicrob. Agents Chemother. August 2005 49: 3554-3557;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Transfer of Plasmid-Encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an Infant and Selection of Impermeability to Imipenem in K. pneumoniae
Philippe Bidet, Béatrice Burghoffer, Valérie Gautier, Naïma Brahimi, Patricia Mariani-Kurkdjian, Alaa El-Ghoneimi, Edouard Bingen, and Guillaume Arlet
Antimicrob. Agents Chemother. August 2005 49: 3562-3565;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inducement and Reversal of Tetracycline Resistance in Escherichia coli K-12 and Expression of Proton Gradient-Dependent Multidrug Efflux Pump Genes
Miguel Viveiros, Ana Jesus, Mafalda Brito, Clara Leandro, Marta Martins, Diane Ordway, Ana Maria Molnar, Joseph Molnar, and Leonard Amaral
Antimicrob. Agents Chemother. August 2005 49: 3578-3582;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genotypic Diversity of Methicillin-Resistant Staphylococcus aureus Isolates in Korean Hospitals
Kwan Soo Ko, Yeon-Sook Kim, Jae-Hoon Song, Joon-Sup Yeom, Hyuck Lee, Sook-In Jung, Doo-Ryun Jeong, Shin-Woo Kim, Hyun-Ha Chang, Hyun Kyun Ki, Chisook Moon, Won Sup Oh, Kyong Ran Peck, and Nam Yong Lee
Antimicrob. Agents Chemother. August 2005 49: 3583-3585;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of Resistance Mechanisms against Macrolides and Lincosamides in Methicillin-Resistant Coagulase-Negative Staphylococci in the Czech Republic and Occurrence of an Undefined Mechanism of Resistance to Lincosamides
Gabriela Novotna, Václava Adamkova, Jiri Janata, Oto Melter, and Jaroslav Spizek
Antimicrob. Agents Chemother. August 2005 49: 3586-3589;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Genetic Structure Associated with an Extended-Spectrum ß-Lactamase bla_VEB Gene in a Providencia stuartii Clinical Isolate from Algeria
Daniel Aubert, Thierry Naas, Marie-Frédérique Lartigue, and Patrice Nordmann
Antimicrob. Agents Chemother. August 2005 49: 3590-3592;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron-Encoded GES-Type Extended-Spectrum ß-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa
Laurent Poirel, Laura Brinas, Nicolas Fortineau, and Patrice Nordmann
Antimicrob. Agents Chemother. August 2005 49: 3593-3597;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

3',5'-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection
Eric Brouillette, Mamoru Hyodo, Yoshihiro Hayakawa, David K. R. Karaolis, and François Malouin
Antimicrob. Agents Chemother. August 2005 49: 3109-3113;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination Therapy with Intravenous Colistin for Management of Infections Due to Multidrug-Resistant Gram-Negative Bacteria in Patients without Cystic Fibrosis
Sofia K. Kasiakou, Argyris Michalopoulos, Elpidoforos S. Soteriades, George Samonis, George J. Sermaides, and Matthew E. Falagas
Antimicrob. Agents Chemother. August 2005 49: 3136-3146;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Countrywide Survey Shows Very High Prevalence of Plasmodium falciparum Multilocus Resistance Genotypes in Cambodia
Nimol Khim, Christiane Bouchier, Marie-Thérèse Ekala, Sandra Incardona, Pharath Lim, Eric Legrand, Ronan Jambou, Socheat Doung, Odile Mercereau Puijalon, and Thierry Fandeur
Antimicrob. Agents Chemother. August 2005 49: 3147-3152;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Telavancin in a Rabbit Model of Aortic Valve Endocarditis Due to Methicillin-Resistant Staphylococcus aureus or Vancomycin-Intermediate Staphylococcus aureus
Andres G. Madrigal, Li Basuino, and Henry F. Chambers
Antimicrob. Agents Chemother. August 2005 49: 3163-3165;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Evaluations of the Activities of Lauric Acid Monoester Formulations against Staphylococcus aureus
Mark S. Rouse, Margalida Rotger, Kerryl E. Piper, James M. Steckelberg, Matthew Scholz, Jeffrey Andrews, and Robin Patel
Antimicrob. Agents Chemother. August 2005 49: 3187-3191;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection
Xin-Xing Tan, Jeffrey K. Actor, and Yin Chen
Antimicrob. Agents Chemother. August 2005 49: 3203-3207;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Production and Characterization of Stable Amphotericin-Resistant Amastigotes and Promastigotes of Leishmania mexicana
Hamdan I. Al-Mohammed, Michael L. Chance, and Paul A. Bates
Antimicrob. Agents Chemother. August 2005 49: 3274-3280;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Systemic Antibacterial Activity of Novel Synthetic Cyclic Peptides
Véronique Dartois, Jorge Sanchez-Quesada, Edelmira Cabezas, Ellen Chi, Chad Dubbelde, Carrie Dunn, Juan Granja, Colleen Gritzen, Dana Weinberger, M. Reza Ghadiri, and Thomas R. Parr, Jr.
Antimicrob. Agents Chemother. August 2005 49: 3302-3310;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Cefepime and Imipenem in Experimental Murine Pneumonia Caused by Porin-Deficient Klebsiella pneumoniae Producing CMY-2 ß-Lactamase
Cristina Pichardo, José Manuel Rodríguez-Martínez, María E. Pachón-Ibañez, Carmen Conejo, José Ibáñez-Martínez, Luis Martínez-Martínez, Jerónimo Pachón, and Álvaro Pascual
Antimicrob. Agents Chemother. August 2005 49: 3311-3316;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes
Elisabeth Kugelberg, Tobias Norström, Thomas K. Petersen, Tore Duvold, Dan I. Andersson, and Diarmaid Hughes
Antimicrob. Agents Chemother. August 2005 49: 3435-3441;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo
Ernest J. Mui, David Jacobus, Wilbur K. Milhous, Guy Schiehser, Honghue Hsu, Craig W. Roberts, Michael J. Kirisits, and Rima McLeod
Antimicrob. Agents Chemother. August 2005 49: 3463-3467;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Daptomycin, Linezolid, and Vancomycin on Establishment of Intestinal Colonization with Vancomycin-Resistant Enterococci and Extended-Spectrum-ß-Lactamase-Producing Klebsiella pneumoniae in Mice
Nicole J. Pultz, Usha Stiefel, and Curtis J. Donskey
Antimicrob. Agents Chemother. August 2005 49: 3513-3516;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Therapeutic Effect of ME1036 on Endocarditis Experimentally Induced by Methicillin-Resistant Staphylococcus aureus
Jun Nagura, Koji Kijima, Mizuyo Kurazono, Sho Takahata, Toshie Sugano, Yukari Tanaka, Yoko Hirai, Keiko Yamada, Yoshihiro Takayama, Eiki Shitara, and Minoru Yonezawa
Antimicrob. Agents Chemother. August 2005 49: 3526-3528;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Antibiotic Treatment on Growth of and Toxin Production by Clostridium difficile in the Cecal Contents of Mice
Nicole J. Pultz and Curtis J. Donskey
Antimicrob. Agents Chemother. August 2005 49: 3529-3532;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Functional Interrelationships between Cell Membrane and Cell Wall in Antimicrobial Peptide-Mediated Killing of Staphylococcus aureus
Yan Q. Xiong, Kasturi Mukhopadhyay, Michael R. Yeaman, Jill Adler-Moore, and Arnold S. Bayer
Antimicrob. Agents Chemother. August 2005 49: 3114-3121;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Neopeptide Antibiotics That Function as Opsonins and Membrane-Permeabilizing Agents for Gram-Negative Bacteria
Haim Tsubery, Hertzig Yaakov, Sofia Cohen, Tal Giterman, Ariella Matityahou, Mati Fridkin, and Itzhak Ofek
Antimicrob. Agents Chemother. August 2005 49: 3122-3128;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of the De Novo Engineered Antimicrobial Peptide WLBU2 against Pseudomonas aeruginosa in Human Serum and Whole Blood: Implications for Systemic Applications
Berthony Deslouches, Kazi Islam, Jodi K. Craigo, Shruti M. Paranjape, Ronald C. Montelaro, and Timothy A. Mietzner
Antimicrob. Agents Chemother. August 2005 49: 3208-3216;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ciprofloxacin Induction of a Susceptibility Determinant in Pseudomonas aeruginosa
Michelle D. Brazas and Robert E. W. Hancock
Antimicrob. Agents Chemother. August 2005 49: 3222-3227;
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Effect of Ciprofloxacin-Induced Prostaglandin E₂ on Interleukin-18-Treated Monocytes
Hideo Kohka Takahashi, Hiromi Iwagaki, Dong Xue, Goutarou Katsuno, Sachi Sugita, Kenji Mizuno, Shuji Mori, Shinya Saito, Tadashi Yoshino, Noriaki Tanaka, and Masahiro Nishibori
Antimicrob. Agents Chemother. August 2005 49: 3228-3233;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi: Prospect for Chemotherapy of Chagas' Disease
Olga Senkovich, Vandanajay Bhatia, Nisha Garg, and Debasish Chattopadhyay
Antimicrob. Agents Chemother. August 2005 49: 3234-3238;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mitochondrial Ribosome as the Target for the Macrolide Antibiotic Clarithromycin in the Helminth Echinococcus multilocularis
Alexander Mathis, Peter Wild, Erik C. Boettger, Christian M. O. Kapel, and Peter Deplazes
Antimicrob. Agents Chemother. August 2005 49: 3251-3255;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Secretion of Proteases by Pseudomonas aeruginosa Biofilms Exposed to Ciprofloxacin
Ewa Oldak and Elzbieta A. Trafny
Antimicrob. Agents Chemother. August 2005 49: 3281-3288;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between In Vitro Activities of Amphotericin B and Flucytosine and pH for Clinical Yeast and Mold Isolates
D. T. A. te Dorsthorst, P. E. Verweij, J. F. G. M. Meis, and J. W. Mouton
Antimicrob. Agents Chemother. August 2005 49: 3341-3346;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Lactoferricin Is Partially Folded in Aqueous Solution and Is Better Stabilized in a Membrane Mimetic Solvent
Howard N. Hunter, A. Ross Demcoe, Håvard Jenssen, Tore J. Gutteberg, and Hans J. Vogel
Antimicrob. Agents Chemother. August 2005 49: 3387-3395;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Azithromycin Inhibits the Formation of Flagellar Filaments without Suppressing Flagellin Synthesis in Salmonella enterica Serovar Typhimurium
Hidenori Matsui, Masahiro Eguchi, Katsufumi Ohsumi, Akio Nakamura, Yasunori Isshiki, Kachiko Sekiya, Yuji Kikuchi, Tohru Nagamitsu, Rokuro Masuma, Toshiaki Sunazuka, and Satoshi Omura
Antimicrob. Agents Chemother. August 2005 49: 3396-3403;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694
Emmanuelle Laffly, Ludivine Danjou, Florence Condemine, Dominique Vidal, Emmanuel Drouet, Marie-Paule Lefranc, Chantal Bottex, and Philippe Thullier
Antimicrob. Agents Chemother. August 2005 49: 3414-3420;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development and Validation of a Whole-Cell Inhibition Assay for Bacterial Methionine Aminopeptidase by Surface-Enhanced Laser Desorption Ionization-Time of Flight Mass Spectrometry
Kenneth D. Greis, Songtao Zhou, Richard Siehnel, Chuck Klanke, Alan Curnow, Jeremy Howard, and Gerlinde Layh-Schmitt
Antimicrob. Agents Chemother. August 2005 49: 3428-3434;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal and Morphological Effects of NE-2001, a Novel Synthetic Agent Directed against Helicobacter pylori
Guofei Dai, Ni Cheng, Lei Dong, Mutsumi Muramatsu, Shudong Xiao, Ming-Wei Wang, and De-Xu Zhu
Antimicrob. Agents Chemother. August 2005 49: 3468-3473;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nystatin Induces Secretion of Interleukin (IL)-1ß, IL-8, and Tumor Necrosis Factor Alpha by a Toll-Like Receptor-Dependent Mechanism
Raymund R. Razonable, Martin Henault, Harold L. Watson, and Carlos V. Paya
Antimicrob. Agents Chemother. August 2005 49: 3546-3549;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate
Wendy C. Magee, Karl Y. Hostetler, and David H. Evans
Antimicrob. Agents Chemother. August 2005 49: 3153-3162;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quantifying Mixed Populations of Drug-Resistant Human Immunodeficiency Virus Type 1
Michael J. Moser, Meta Ruckstuhl, Christine A. Larsen, Amanda J. Swearingen, Miroslaw Kozlowski, Leda Bassit, Prem L. Sharma, Raymond F. Schinazi, and James R. Prudent
Antimicrob. Agents Chemother. August 2005 49: 3334-3340;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2',3'-Didehydro-3'-Deoxy-4'-Ethynylthymidine In Vitro
Takao Nitanda, Xin Wang, Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Yung-Chi Cheng, and Masanori Baba
Antimicrob. Agents Chemother. August 2005 49: 3355-3360;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amprenavir and Efavirenz Pharmacokinetics before and after the Addition of Nelfinavir, Indinavir, Ritonavir, or Saquinavir in Seronegative Individuals
Gene D. Morse, Susan Rosenkranz, Michael F. Para, Yoninah Segal, Robin DiFrancesco, Elizabeth Adams, Barbara Brizz, Kevin E. Yarasheski, Richard C. Reichman the ACTG 5043 Protocol Team
Antimicrob. Agents Chemother. August 2005 49: 3373-3381;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Highly Potent Inhibition of Human Immunodeficiency Virus Type 1 Replication by TAK-220, an Orally Bioavailable Small-Molecule CCR5 Antagonist
Katsunori Takashima, Hiroshi Miyake, Naoyuki Kanzaki, Yoshihiko Tagawa, Xin Wang, Yoshihiro Sugihara, Yuji Iizawa, and Masanori Baba
Antimicrob. Agents Chemother. August 2005 49: 3474-3482;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

TAK-220, a Novel Small-Molecule CCR5 Antagonist, Has Favorable Anti-Human Immunodeficiency Virus Interactions with Other Antiretrovirals In Vitro
Cécile L. Tremblay, Françoise Giguel, Yongbiao Guan, Ting-Chao Chou, Katsunori Takashima, and Martin S. Hirsch
Antimicrob. Agents Chemother. August 2005 49: 3483-3485;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Real-Time PCR Screening for 16S rRNA Mutations Associated with Resistance to Tetracycline in Helicobacter pylori
Erik Glocker, Marco Berning, Monique M. Gerrits, Johannes G. Kusters, and Manfred Kist
Antimicrob. Agents Chemother. August 2005 49: 3166-3170;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antibacterial Activities of CS-023 (RO4908463), a Novel Parenteral Carbapenem
Tetsufumi Koga, Tomomi Abe, Harumi Inoue, Takashi Takenouchi, Akiko Kitayama, Tatsuhiko Yoshida, Nobuhisa Masuda, Chika Sugihara, Masayo Kakuta, Miyuki Nakagawa, Takahiro Shibayama, Yoko Matsushita, Takashi Hirota, Satoshi Ohya, Yukio Utsui, Takashi Fukuoka, and Syogo Kuwahara
Antimicrob. Agents Chemother. August 2005 49: 3239-3250;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Four Methods for Determining Lysostaphin Susceptibility of Various Strains of Staphylococcus aureus
Caroline M. Kusuma and John F. Kokai-Kun
Antimicrob. Agents Chemother. August 2005 49: 3256-3263;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Correspondence of In Vitro and In Vivo Fluconazole Dose-Response Curves for Cryptococcus neoformans
Robert A. Larsen, Madeline Bauer, Ann M. Thomas, Alejandro Sanchez, Diane Citron, Meri Rathbun, and Thomas S. Harrison
Antimicrob. Agents Chemother. August 2005 49: 3297-3301;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antistaphylococcal Activity of DX-619, a New Des-F(6)-Quinolone, Compared to Those of Other Agents
Tatiana Bogdanovich, Duygu Esel, Linda M. Kelly, Bülent Bozdogan, Kim Credito, Gengrong Lin, Kathy Smith, Lois M. Ednie, Dianne B. Hoellman, and Peter C. Appelbaum
Antimicrob. Agents Chemother. August 2005 49: 3325-3333;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Caspofungin Susceptibility Testing of Candida inconspicua: Correlation of Different Methods with the Minimal Fungicidal Concentration
L. Majoros, G. Kardos, B. Szabó, and M. Sipiczki
Antimicrob. Agents Chemother. August 2005 49: 3486-3488;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Efficacy of the Combination of Ciprofloxacin and Cefotaxime against Vibrio vulnificus
Dong-Min Kim, Yong Lym, Sook Jin Jang, Hulin Han, Young Gi Kim, Choon-Hae Chung, and Soon Pyo Hong
Antimicrob. Agents Chemother. August 2005 49: 3489-3491;
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Antifungal Susceptibility of 596 Aspergillus fumigatus Strains Isolated from Outdoor Air, Hospital Air, and Clinical Samples: Analysis by Site of Isolation
J. Guinea, T. Peláez, L. Alcalá, M. J. Ruiz-Serrano, and E. Bouza
Antimicrob. Agents Chemother. August 2005 49: 3495-3497;
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In Vitro Synergistic Interaction between Amphotericin B and Micafungin against Scedosporium spp.
Clara Yustes and Josep Guarro
Antimicrob. Agents Chemother. August 2005 49: 3498-3500;
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Antimicrobial Activity and Spectrum of PPI-0903M (T-91825), a Novel Cephalosporin, Tested against a Worldwide Collection of Clinical Strains
Helio S. Sader, Thomas R. Fritsche, Koné Kaniga, Yigong Ge, and Ronald N. Jones
Antimicrob. Agents Chemother. August 2005 49: 3501-3512;
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In Vitro Interaction of Posaconazole and Caspofungin against Clinical Isolates of Candida glabrata
E. R. Oliveira, A. W. Fothergill, W. R. Kirkpatrick, B. J. Coco, T. F. Patterson, and S. W. Redding
Antimicrob. Agents Chemother. August 2005 49: 3544-3545;
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In Vitro Synergy Testing of Anidulafungin with Itraconazole, Voriconazole, and Amphotericin B against Aspergillus spp. and Fusarium spp.
Annie Philip, Zekaver Odabasi, Jose Rodriguez, Victor L. Paetznick, Enuo Chen, John H. Rex, and Luis Ostrosky-Zeichner
Antimicrob. Agents Chemother. August 2005 49: 3572-3574;
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Simple Histidine-Rich Protein 2 Double-Site Sandwich Enzyme-Linked Immunosorbent Assay for Use in Malaria Drug Sensitivity Testing
Harald Noedl, Jan Bronnert, Kritsanai Yingyuen, Bernhard Attlmayr, Herwig Kollaritsch, and Mark Fukuda
Antimicrob. Agents Chemother. August 2005 49: 3575-3577;
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Clinical Therapeutics:

Fluconazole MIC and the Fluconazole Dose/MIC Ratio Correlate with Therapeutic Response among Patients with Candidemia
Cornelius J. Clancy, Victor L. Yu, Arthur J. Morris, David R. Snydman, and M. Hong Nguyen
Antimicrob. Agents Chemother. August 2005 49: 3171-3177;
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Efficacy of the Combination Rifampin-Streptomycin in Preventing Growth of Mycobacterium ulcerans in Early Lesions of Buruli Ulcer in Humans
S. Etuaful, B. Carbonnelle, J. Grosset, S. Lucas, C. Horsfield, R. Phillips, M. Evans, D. Ofori-Adjei, E. Klustse, J. Owusu-Boateng, G. K. Amedofu, P. Awuah, E. Ampadu, G. Amofah, K. Asiedu, and M. Wansbrough-Jones
Antimicrob. Agents Chemother. August 2005 49: 3182-3186;
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Acquisition of Resistant Bowel Flora during a Double-Blind Randomized Clinical Trial of Ertapenem versus Piperacillin-Tazobactam Therapy for Intraabdominal Infections
Mark J. DiNubile, Joseph W. Chow, Vilas Satishchandran, Adam Polis, Mary R. Motyl, Murray A. Abramson, and Hedy Teppler
Antimicrob. Agents Chemother. August 2005 49: 3217-3221;
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Safety, Tolerability, and Pharmacokinetics of Micafungin (FK463) in Febrile Neutropenic Pediatric Patients
Nita L. Seibel, Cindy Schwartz, Antonio Arrieta, Patricia Flynn, Aziza Shad, Edith Albano, James Keirns, Wendi M. Lau, David P. Facklam, Donald N. Buell, and Thomas J. Walsh
Antimicrob. Agents Chemother. August 2005 49: 3317-3324;
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Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naïve, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors
Patrick F. Smith, Gregory K. Robbins, Robert W. Shafer, Hulin Wu, Song Yu, Martin S. Hirsch, Thomas C. Merigan, Jeong-Gun Park, Alan Forrest, Margaret A. Fischl, Gene D. Morse, and the ACTG 384-5006 Team
Antimicrob. Agents Chemother. August 2005 49: 3558-3561;
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Effect of Various Antibacterial Preparations on the Pathogenic Oral Flora in Elderly Patients Fed via Nasogastric Tube
Arthur Leibovitz, Yehuda Carmeli, and Refael Segal
Antimicrob. Agents Chemother. August 2005 49: 3566-3568;
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Pharmacology:

Population Pharmacokinetics of Tenofovir in Human Immunodeficiency Virus-Infected Patients Taking Highly Active Antiretroviral Therapy
Vincent Jullien, Jean-Marc Tréluyer, Elisabeth Rey, Patrick Jaffray, Anne Krivine, Laurence Moachon, Agnès Lillo-Le Louet, Anne Lescoat, Nicolas Dupin, Dominique Salmon, Gérard Pons, and Saïk Urien
Antimicrob. Agents Chemother. August 2005 49: 3361-3366;
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Ceftazidime in Acute Myeloid Leukemia Patients with Febrile Neutropenia: Helpfulness of Continuous Intravenous Infusion in Maximizing Pharmacodynamic Exposure
Federico Pea, Pierluigi Viale, Daniela Damiani, Federica Pavan, Francesco Cristini, Renato Fanin, and Mario Furlanut
Antimicrob. Agents Chemother. August 2005 49: 3550-3553;
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Analytical Procedures:

Fluorescence Polarization Method To Characterize Macrolide-Ribosome Interactions
Kang Yan, Eric Hunt, John Berge, Earl May, Robert A. Copeland, and Richard R. Gontarek
Antimicrob. Agents Chemother. August 2005 49: 3367-3372;
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Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum
GholamAli Khoschsorur, Franz Fruehwirth, and Sieglinde Zelzer
Antimicrob. Agents Chemother. August 2005 49: 3569-3571;
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Letters:

Strain-Specific Expression Levels of pbp4 Exist in Isolates of Glycopeptide-Intermediate Staphylococcus aureus (GISA) and Heterogeneous GISA
M. Wootton, P. M. Bennett, A. P. MacGowan, and T. R. Walsh
Antimicrob. Agents Chemother. August 2005 49: 3598-3599;
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