Contents: October 2006, Volume 50, Issue 10        Minireviews        Mechanisms of Resistance        Clinical Therapeutics        Antiviral Agents        Mechanisms of Action        Experimental Therapeutics        Susceptibility        Pharmacology        Analytical Procedures        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Resistance of Yersinia pestis to Antimicrobial Agents Marc Galimand, Elisabeth Carniel, and Patrice Courvalin Antimicrob. Agents Chemother. October 2006 50: 3233-3236; [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Origins and Evolution of Methicillin-Resistant Staphylococcus aureus Clonal Lineages A. R. Gomes, H. Westh, and H. de Lencastre Antimicrob. Agents Chemother. October 2006 50: 3237-3244; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Total Variation in the penA Gene of Neisseria meningitidis: Correlation between Susceptibility to ß-Lactam Antibiotics and penA Gene Heterogeneity Sara Thulin, Per Olcén, Hans Fredlund, and Magnus Unemo Antimicrob. Agents Chemother. October 2006 50: 3317-3324; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The mef(E)-Carrying Genetic Element (mega) of Streptococcus pneumoniae: Insertion Sites and Association with Other Genetic Elements Maria Del Grosso, Romina Camilli, Francesco Iannelli, Gianni Pozzi, and Annalisa Pantosti Antimicrob. Agents Chemother. October 2006 50: 3361-3366; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Level Carbapenem Resistance in a Klebsiella pneumoniae Clinical Isolate Is Due to the Combination of blaACT-1 ß-Lactamase Production, Porin OmpK35/36 Insertional Inactivation, and Down-Regulation of the Phosphate Transport Porin PhoE Frank M. Kaczmarek, Fadia Dib-Hajj, Wenchi Shang, and Thomas D. Gootz Antimicrob. Agents Chemother. October 2006 50: 3396-3406; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of VraSR in Antibiotic Resistance and Antibiotic-Induced Stress Response in Staphylococcus aureus S. Gardete, S. W. Wu, S. Gill, and A. Tomasz Antimicrob. Agents Chemother. October 2006 50: 3424-3434; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli Hanna Örlén and Diarmaid Hughes Antimicrob. Agents Chemother. October 2006 50: 3454-3456; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Redefining a Structural Variant of Staphylococcal Cassette Chromosome mec, SCCmec Type VI Duarte C. Oliveira, Catarina Milheiriço, and Hermínia de Lencastre Antimicrob. Agents Chemother. October 2006 50: 3457-3459; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Method for Regulated Expression of Single-Copy Efflux Pump Genes in a Surrogate Pseudomonas aeruginosa Strain: Identification of the BpeEF-OprC Chloramphenicol and Trimethoprim Efflux Pump of Burkholderia pseudomallei 1026b Ayush Kumar, Kim-Lee Chua, and Herbert P. Schweizer Antimicrob. Agents Chemother. October 2006 50: 3460-3463; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intrinsic Macrolide Resistance in Rapidly Growing Mycobacteria Kevin A. Nash, Nadya Andini, Yansheng Zhang, Barbara A. Brown-Elliott, and Richard J. Wallace, Jr. Antimicrob. Agents Chemother. October 2006 50: 3476-3478; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

SME-3, a Novel Member of the Serratia marcescens SME Family of Carbapenem-Hydrolyzing ß-Lactamases Anne Marie Queenan, Wenchi Shang, Paul Schreckenberger, Karen Lolans, Karen Bush, and John Quinn Antimicrob. Agents Chemother. October 2006 50: 3485-3487; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Deletions of the Endocytic Components VPS28 and VPS32 in Candida albicans Lead to Echinocandin and Azole Hypersensitivity Muriel Cornet, Claude Gaillardin, and Mathias L. Richard Antimicrob. Agents Chemother. October 2006 50: 3492-3495; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Pharmacokinetics and Tolerability of Daptomycin at Doses up to 12 Milligrams per Kilogram of Body Weight Once Daily in Healthy Volunteers Mark Benvenuto, David P. Benziger, Sara Yankelev, and Gloria Vigliani Antimicrob. Agents Chemother. October 2006 50: 3245-3249; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Inactive Empiric Antimicrobial Therapy on Inpatient Mortality and Length of Stay Kimberly K. Scarsi, Joe M. Feinglass, Marc H. Scheetz, Michael J. Postelnick, Maureen K. Bolon, and Gary A. Noskin Antimicrob. Agents Chemother. October 2006 50: 3355-3360; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Tigecycline on Normal Oropharyngeal and Intestinal Microflora Carl Erik Nord, Eva Sillerström, and Elisabeth Wahlund Antimicrob. Agents Chemother. October 2006 50: 3375-3380; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phase I Dose Escalation Study To Evaluate the Safety and Pharmacokinetic Profile of Tefibazumab in Subjects with End-Stage Renal Disease Requiring Hemodialysis Seth Hetherington, Michele Texter, Eric Wenzel, Joseph M. Patti, Laurie Reynolds, Trish Shamp, and Suzanne Swan Antimicrob. Agents Chemother. October 2006 50: 3499-3500; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Engineered Vaginal Lactobacillus Strain for Mucosal Delivery of the Human Immunodeficiency Virus Inhibitor Cyanovirin-N Xiaowen Liu, Laurel A. Lagenaur, David A. Simpson, Kirsten P. Essenmacher, Courtney L. Frazier-Parker, Yang Liu, Daniel Tsai, Srinivas S. Rao, Dean H. Hamer, Thomas P. Parks, Peter P. Lee, and Qiang Xu Antimicrob. Agents Chemother. October 2006 50: 3250-3259; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Robust Hepatitis C Virus Mouse Efficacy Model Qing Zhu, Yoko Oei, Dirk B. Mendel, Evelyn N. Garrett, Montesa B. Patawaran, Paul W. Hollenbach, Sharon L. Aukerman, and Amy J. Weiner Antimicrob. Agents Chemother. October 2006 50: 3260-3268; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent Antiviral Synergy between Monoclonal Antibody and Small-Molecule CCR5 Inhibitors of Human Immunodeficiency Virus Type 1 Jose D. Murga, Michael Franti, Daniel C. Pevear, Paul J. Maddon, and William C. Olson Antimicrob. Agents Chemother. October 2006 50: 3289-3296; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Active Renal Tubular Efflux of Tenofovir Adrian S. Ray, Tomas Cihlar, Kelly L. Robinson, Leah Tong, Jennifer E. Vela, Michael D. Fuller, Lani M. Wieman, Eugene J. Eisenberg, and Gerry R. Rhodes Antimicrob. Agents Chemother. October 2006 50: 3297-3304; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bile Salt-Stimulated Lipase from Human Milk Binds DC-SIGN and Inhibits Human Immunodeficiency Virus Type 1 Transfer to CD4+ T Cells Marloes A. Naarding, Annette M. Dirac, Irene S. Ludwig, Dave Speijer, Susanne Lindquist, Eva-Lotta Vestman, Martijn J. Stax, Teunis B. H. Geijtenbeek, Georgios Pollakis, Olle Hernell, and William A. Paxton Antimicrob. Agents Chemother. October 2006 50: 3367-3374; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of a Human Immunodeficiency Virus Vector-Based, Single-Cycle Assay for Evaluation of Anti-Integrase Compounds Roberta Bona, Mauro Andreotti, Viviana Buffa, Pasqualina Leone, Clementina Maria Galluzzo, Roberta Amici, Lucia Palmisano, Maria Grazia Mancini, Zuleika Michelini, Roberto Di Santo, Roberta Costi, Alessandra Roux, Yves Pommier, Christophe Marchand, Stefano Vella, and Andrea Cara Antimicrob. Agents Chemother. October 2006 50: 3407-3417; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2'-C-Methylcytidine, the Active Component of Valopicitabine Lotte Coelmont, Jan Paeshuyse, Marc P. Windisch, Erik De Clercq, Ralf Bartenschlager, and Johan Neyts Antimicrob. Agents Chemother. October 2006 50: 3444-3446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhanced Antiscrapie Effect Using Combination Drug Treatment David A. Kocisko, Byron Caughey, John D. Morrey, and Richard E. Race Antimicrob. Agents Chemother. October 2006 50: 3447-3449; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Maribavir Antagonizes the Antiviral Action of Ganciclovir on Human Cytomegalovirus Sunwen Chou and Gail I. Marousek Antimicrob. Agents Chemother. October 2006 50: 3470-3472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Biofilm Formation by the Emerging Fungal Pathogen Trichosporon asahii: Development, Architecture, and Antifungal Resistance Giovanni Di Bonaventura, Arianna Pompilio, Carla Picciani, Manuela Iezzi, Domenico D'Antonio, and Raffaele Piccolomini Antimicrob. Agents Chemother. October 2006 50: 3269-3276; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of PEX, a Noncatalytic Metalloproteinase Fragment with Integrin-Binding Activity, on Experimental Chlamydophila pneumoniae Infection Dario Caronzolo, Valeria Lucini, Marilou Pannacci, Silvia Grosso, Nelly Kieffer, Lorenzo Bello, Andreas Bikfalvi, and Francesco Scaglione Antimicrob. Agents Chemother. October 2006 50: 3277-3282; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhanced Membrane Disruption and Antibiotic Action against Pathogenic Bacteria by Designed Histidine-Rich Peptides at Acidic pH A. James Mason, Claire Gasnier, Antoine Kichler, Gilles Prévost, Dominique Aunis, Marie-Hélène Metz-Boutigue, and Burkhard Bechinger Antimicrob. Agents Chemother. October 2006 50: 3305-3311; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Throughput and Facile Assay of Antimicrobial Peptides Using pH-Controlled Fluorescence Resonance Energy Transfer Young Soo Kim and Hyung Joon Cha Antimicrob. Agents Chemother. October 2006 50: 3330-3335; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent Antihematozoan Activity of Novel Bisthiazolium Drug T16: Evidence for Inhibition of Phosphatidylcholine Metabolism in Erythrocytes Infected with Babesia and Plasmodium spp. Eric Richier, Giancarlo A. Biagini, Sharon Wein, Frederic Boudou, Patrick G. Bray, Steve A. Ward, Eric Precigout, Michèle Calas, Jean-François Dubremetz, and Henri J. Vial Antimicrob. Agents Chemother. October 2006 50: 3381-3388; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

System for Expression of Microsporidian Methionine Amino Peptidase Type 2 (MetAP2) in the Yeast Saccharomyces cerevisiae Rajendra Upadhya, Hong Shan Zhang, and Louis M. Weiss Antimicrob. Agents Chemother. October 2006 50: 3389-3395; published ahead of print August 17, 2006, doi:10.1128/AAC.00726-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structure-Activity Relationships of Bacillus cereus and Bacillus anthracis Dihydrofolate Reductase: toward the Identification of New Potent Drug Leads Tammy M. Joska and Amy C. Anderson Antimicrob. Agents Chemother. October 2006 50: 3435-3443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Protein O-Mannosyltransferase Isoforms Regulate Biofilm Formation in Candida albicans Heidrun Peltroche-Llacsahuanga, Sophie Goyard, Christophe d'Enfert, Stephan K.-H. Prill, and Joachim F. Ernst Antimicrob. Agents Chemother. October 2006 50: 3488-3491; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Comparative In Vitro Efficacies and Antimicrobial Durabilities of Novel Antimicrobial Central Venous Catheters Hend Hanna, Paul Bahna, Ruth Reitzel, Tanya Dvorak, Gassan Chaiban, Ray Hachem, and Issam Raad Antimicrob. Agents Chemother. October 2006 50: 3283-3288; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Filamentation Can Be Used To Treat Disseminated Candidiasis Stephen P. Saville, Anna L. Lazzell, Alexander P. Bryant, Angelika Fretzen, Alex Monreal, Erik O. Solberg, Carlos Monteagudo, Jose L. Lopez-Ribot, and G. Todd Milne Antimicrob. Agents Chemother. October 2006 50: 3312-3316; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mycobacterium leprae Is Naturally Resistant to PA-824 Ujjini H. Manjunatha, Ramanuj Lahiri, Baljit Randhawa, Cynthia S. Dowd, James L. Krahenbuhl, and Clifton E. Barry, III Antimicrob. Agents Chemother. October 2006 50: 3350-3354; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Ambruticin Analogs in a Murine Model of Invasive Pulmonary Aspergillosis Lisa Y. Chiang, Daniele E. Ejzykowicz, Zong-Qiang Tian, Leonard Katz, and Scott G. Filler Antimicrob. Agents Chemother. October 2006 50: 3464-3466; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis Lisa F. Shubitz, John N. Galgiani, Zong-Qiang Tian, Ziyang Zhong, Pieter Timmermans, and Leonard Katz Antimicrob. Agents Chemother. October 2006 50: 3467-3469; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis Donald C. Sheppard, John R. Graybill, Laura K. Najvar, Lisa Y. Chiang, Thomas Doedt, William R. Kirkpatrick, Rosie Bocanegra, Ana C. Vallor, Thomas F. Patterson, and Scott G. Filler Antimicrob. Agents Chemother. October 2006 50: 3501-3503; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Ciprofloxacin-Resistant Gram-Negative Bacilli in the Fecal Microflora of Children Xuan Qin, Yasmin Razia, James R. Johnson, Jennifer R. Stapp, Daniel R. Boster, Treva Tsosie, Donna L. Smith, Christopher R. Braden, Kathryn Gay, Frederick J. Angulo, and Phillip I. Tarr Antimicrob. Agents Chemother. October 2006 50: 3325-3329; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessment of the Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa by Using a Plasmodium Lactate Dehydrogenase Immunodetection Assay and an Inhibitory Maximum Effect Model for Precise Measurement of the 50-Percent Inhibitory Concentration Halima Kaddouri, Serge Nakache, Sandrine Houzé, France Mentré, and Jacques Le Bras Antimicrob. Agents Chemother. October 2006 50: 3343-3349; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Clostridium difficile Clinical Isolates from a Multi-Institutional Outbreak in Southern Québec, Canada Anne-Marie Bourgault, François Lamothe, Vivian G. Loo, Louise Poirier, and the CDAD-CSI Study Group Antimicrob. Agents Chemother. October 2006 50: 3473-3475; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility among Pathogens Collected from Hospitalized Patients in the United States and In Vitro Activity of Tigecycline, a New Glycylcycline Antimicrobial Ken B. Waites, Lynn B. Duffy, and Michael J. Dowzicky Antimicrob. Agents Chemother. October 2006 50: 3479-3484; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Breakthrough Candida Bloodstream Isolates Correlates with Daily and Cumulative Doses of Fluconazole Cornelius J. Clancy, Benjamin Staley, and M. Hong Nguyen Antimicrob. Agents Chemother. October 2006 50: 3496-3498; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Susceptibilities of 396 Unusual Anaerobic Strains to Tigecycline and Eight Other Antimicrobial Agents Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, and Helen T. Fernandez Antimicrob. Agents Chemother. October 2006 50: 3507-3513; published ahead of print August 28, 2006, doi:10.1128/AAC.00499-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Effect of Rifampin on Steady-State Pharmacokinetics of Atazanavir with Ritonavir in Healthy Volunteers D. M. Burger, S. Agarwala, M. Child, A. Been-Tiktak, Y. Wang, and R. Bertz Antimicrob. Agents Chemother. October 2006 50: 3336-3342; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Compartmentalized Intrapulmonary Pharmacokinetics of Amphotericin B and Its Lipid Formulations Andreas H. Groll, Caron A. Lyman, Vidmantas Petraitis, Ruta Petraitiene, Derek Armstrong, Diana Mickiene, Raul M. Alfaro, Robert L. Schaufele, Tin Sein, John Bacher, and Thomas J. Walsh Antimicrob. Agents Chemother. October 2006 50: 3418-3423; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs Andrew Crowe, Kenneth F. Ilett, Harin A. Karunajeewa, Kevin T. Batty, and Timothy M. E. Davis Antimicrob. Agents Chemother. October 2006 50: 3504-3506; published ahead of print August 17, 2006, doi:10.1128/AAC.00708-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Reactivity of (13)-ß-D-Glucan Assay with Commonly Used Intravenous Antimicrobials Francisco M. Marty, Colleen M. Lowry, Steven J. Lempitski, David W. Kubiak, Malcolm A. Finkelman, and Lindsey R. Baden Antimicrob. Agents Chemother. October 2006 50: 3450-3453; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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linG, a New Integron-Associated Gene Cassette Encoding a Lincosamide Nucleotidyltransferase Renee S. Levings, Ruth M. Hall, Diane Lightfoot, and Steven P. Djordjevic Antimicrob. Agents Chemother. October 2006 50: 3514-3515; [Full Text] [PDF] [Reprints and Permissions]

Multidrug-Resistant Salmonella enterica Serovar Typhi Isolates with High-Level Resistance to Ciprofloxacin in Dhaka, Bangladesh Dilruba Ahmed, Liton T. D'Costa, Khorshed Alam, G. Balakrish Nair, and M. Anowar Hossain Antimicrob. Agents Chemother. October 2006 50: 3516-3517; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.