Contents: December 2006, Volume 50, Issue 12        Clinical Therapeutics        Experimental Therapeutics        Antiviral Agents        Mechanisms of Resistance        Susceptibility        Pharmacology        Mechanisms of Action        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Clinical Therapeutics:

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Serum and Cerebrospinal Fluid Concentrations of Linezolid in Neurosurgical Patients Pavlos Myrianthefs, Sophia L. Markantonis, Konstantinos Vlachos, Maria Anagnostaki, Eleni Boutzouka, Dimitris Panidis, and Georgios Baltopoulos Antimicrob. Agents Chemother. December 2006 50: 3971-3976; published ahead of print September 18, 2006, doi:10.1128/AAC.00051-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of Trichomonas vaginalis Isolates with Resistance to Metronidazole and Tinidazole Jane R. Schwebke and Frank J. Barrientes Antimicrob. Agents Chemother. December 2006 50: 4209-4210; published ahead of print September 25, 2006, doi:10.1128/AAC.00814-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Treatment and Prevention of Staphylococcus epidermidis Experimental Biomaterial-Associated Infection by Bactericidal Peptide 2 Paulus H. S. Kwakman, Anje A. te Velde, Christina M. J. E. Vandenbroucke-Grauls, Sander J. H. van Deventer, and Sebastian A. J. Zaat Antimicrob. Agents Chemother. December 2006 50: 3977-3983; published ahead of print September 25, 2006, doi:10.1128/AAC.00575-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of High Doses of Levofloxacin in Experimental Foreign-Body Infection by Methicillin-Susceptible Staphylococcus aureus O. Murillo, A. Doménech, A. Garcia, F. Tubau, C. Cabellos, F. Gudiol, and J. Ariza Antimicrob. Agents Chemother. December 2006 50: 4011-4017; published ahead of print October 2, 2006, doi:10.1128/AAC.00523-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Modification of Enrofloxacin Treatment Regimens for Poultry Experimentally Infected with Salmonella enterica Serovar Typhimurium DT104 To Minimize Selection of Resistance Luke P. Randall, Sue W. Cooles, Nick C. Coldham, Ken S. Stapleton, Laura J. V. Piddock, and Martin J. Woodward Antimicrob. Agents Chemother. December 2006 50: 4030-4037; published ahead of print October 9, 2006, doi:10.1128/AAC.00525-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effective Prevention of Microbial Biofilm Formation on Medical Devices by Low-Energy Surface Acoustic Waves Zadik Hazan, Jona Zumeris, Harold Jacob, Hanan Raskin, Gera Kratysh, Moshe Vishnia, Naama Dror, Tilda Barliya, Mathilda Mandel, and Gad Lavie Antimicrob. Agents Chemother. December 2006 50: 4144-4152; published ahead of print August 28, 2006, doi:10.1128/AAC.00418-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans J. C. Bowman, G. K. Abruzzo, A. M. Flattery, C. J. Gill, E. J. Hickey, M. J. Hsu, J. Nielsen Kahn, P. A. Liberator, A. S. Misura, B. A. Pelak, T. C. Wang, and C. M. Douglas Antimicrob. Agents Chemother. December 2006 50: 4202-4205; published ahead of print October 2, 2006, doi:10.1128/AAC.00485-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Glibenclamide, a Blocker of K+ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis Xenón Serrano-Martín, Gilberto Payares, and Alexis Mendoza-León Antimicrob. Agents Chemother. December 2006 50: 4214-4216; published ahead of print October 2, 2006, doi:10.1128/AAC.00617-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Novel Alpha Interferon (IFN-) Variant with Improved Inhibitory Activity against Hepatitis C Virus Genotype 1 Replication Compared to IFN-2b Therapy in a Subgenomic Replicon System Vanessa Escuret, Amaury Martin, David Durantel, Romain Parent, Olivier Hantz, Christian Trépo, Thierry Menguy, Emmanuel Bottius, Jerome Dardy, Jean Maral, Jean Louis Escary, and Fabien Zoulim Antimicrob. Agents Chemother. December 2006 50: 3984-3991; published ahead of print October 9, 2006, doi:10.1128/AAC.00199-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice Matthieu Prot, Laurence Heripret, Nathalie Cardot-Leccia, Christophe Perrin, Myriam Aouadi, Thibaud Lavrut, Rodolphe Garraffo, Pierre Dellamonica, Jacques Durant, Yannick Le Marchand-Brustel, and Bernard Binétruy Antimicrob. Agents Chemother. December 2006 50: 3998-4004; published ahead of print September 25, 2006, doi:10.1128/AAC.00625-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biocompatibility of Solid-Dosage Forms of Anti-Human Immunodeficiency Virus Type 1 Microbicides with the Human Cervicovaginal Mucosa Modeled Ex Vivo Radiana T. Trifonova, Jenna-Malia Pasicznyk, and Raina N. Fichorova Antimicrob. Agents Chemother. December 2006 50: 4005-4010; published ahead of print October 9, 2006, doi:10.1128/AAC.00588-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in the E9L Polymerase Gene of Cidofovir-Resistant Vaccinia Virus Strain WR Are Associated with the Drug Resistance Phenotype Richard S. Kornbluth, Donald F. Smee, Robert W. Sidwell, Victoria Snarsky, David H. Evans, and Karl Y. Hostetler Antimicrob. Agents Chemother. December 2006 50: 4038-4043; published ahead of print September 18, 2006, doi:10.1128/AAC.00380-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Human Immunodeficiency Virus Type 1 Resistance Selections with Combinations of Tenofovir and Emtricitabine or Abacavir and Lamivudine N. A. Margot, J. M. Waters, and M. D. Miller Antimicrob. Agents Chemother. December 2006 50: 4087-4095; published ahead of print September 18, 2006, doi:10.1128/AAC.00816-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor Anita Y. M. Howe, Huiming Cheng, Ian Thompson, Srinivas K. Chunduru, Steve Herrmann, John O'Connell, Atul Agarwal, Rajiv Chopra, and Alfred M. Del Vecchio Antimicrob. Agents Chemother. December 2006 50: 4103-4113; published ahead of print August 28, 2006, doi:10.1128/AAC.00365-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues Hélène Dutartre, Cécile Bussetta, Joëlle Boretto, and Bruno Canard Antimicrob. Agents Chemother. December 2006 50: 4161-4169; published ahead of print September 25, 2006, doi:10.1128/AAC.00433-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Prevalence of the K65R Mutation in Human Immunodeficiency Virus Type 1 Subtype C Isolates from Infected Patients in Botswana Treated with Didanosine-Based Regimens Florence Doualla-Bell, Ava Avalos, Bluma Brenner, Tendani Gaolathe, Madisa Mine, Simani Gaseitsiwe, Maureen Oliveira, Daniella Moisi, Ndwapi Ndwapi, Howard Moffat, Max Essex, and Mark A. Wainberg Antimicrob. Agents Chemother. December 2006 50: 4182-4185; published ahead of print October 2, 2006, doi:10.1128/AAC.00714-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Prevalence and Genetic Analysis of Plasmid-Mediated Quinolone Resistance Determinants QnrA and QnrS in Enterobacteriaceae Isolates from a French University Hospital Laurent Poirel, Cécile Leviandier, and Patrice Nordmann Antimicrob. Agents Chemother. December 2006 50: 3992-3997; published ahead of print September 18, 2006, doi:10.1128/AAC.00597-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

LfrR Is a Repressor That Regulates Expression of the Efflux Pump LfrA in Mycobacterium smegmatis Silvia Buroni, Giulia Manina, Paola Guglierame, Maria Rosalia Pasca, Giovanna Riccardi, and Edda De Rossi Antimicrob. Agents Chemother. December 2006 50: 4044-4052; published ahead of print October 16, 2006, doi:10.1128/AAC.00656-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Penicillin-Binding Protein (PBP) Genes and in Non-PBP Genes during Selection of Penicillin-Resistant Streptococcus gordonii Marisa Haenni and Philippe Moreillon Antimicrob. Agents Chemother. December 2006 50: 4053-4061; published ahead of print September 25, 2006, doi:10.1128/AAC.00676-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutational Analysis of Class A and Class B Penicillin-Binding Proteins in Streptococcus gordonii Marisa Haenni, Paul A. Majcherczyk, Jean-Luc Barblan, and Philippe Moreillon Antimicrob. Agents Chemother. December 2006 50: 4062-4069; published ahead of print September 25, 2006, doi:10.1128/AAC.00677-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Evolutionary Variant of the Streptogramin A Resistance Protein, Vga(A)LC, from Staphylococcus haemolyticus with Shifted Substrate Specificity towards Lincosamides G. Novotna and J. Janata Antimicrob. Agents Chemother. December 2006 50: 4070-4076; published ahead of print October 2, 2006, doi:10.1128/AAC.00799-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical Center Kristine M. Hujer, Andrea M. Hujer, Edward A. Hulten, Saralee Bajaksouzian, Jennifer M. Adams, Curtis J. Donskey, David J. Ecker, Christian Massire, Mark W. Eshoo, Rangarajan Sampath, Jodi M. Thomson, Philip N. Rather, David W. Craft, Joel T. Fishbain, Allesa J. Ewell, Michael R. Jacobs, David L. Paterson, and Robert A. Bonomo Antimicrob. Agents Chemother. December 2006 50: 4114-4123; published ahead of print September 25, 2006, doi:10.1128/AAC.00778-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Asp104 in the SHV ß-Lactamase Christopher R. Bethel, Andrea M. Hujer, Kristine M. Hujer, Jodi M. Thomson, Mark W. Ruszczycky, Vernon E. Anderson, Marianne Pusztai-Carey, Magdalena Taracila, Marion S. Helfand, and Robert A. Bonomo Antimicrob. Agents Chemother. December 2006 50: 4124-4131; published ahead of print September 18, 2006, doi:10.1128/AAC.00848-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Analysis of DNA Gyrase Mutant Enzymes Carrying Mutations at Position 88 in the A Subunit Found in Clinical Strains of Mycobacterium tuberculosis Resistant to Fluoroquinolones Stéphanie Matrat, Nicolas Veziris, Claudine Mayer, Vincent Jarlier, Chantal Truffot-Pernot, Juliette Camuset, Elisabeth Bouvet, Emmanuelle Cambau, and Alexandra Aubry Antimicrob. Agents Chemother. December 2006 50: 4170-4173; published ahead of print October 2, 2006, doi:10.1128/AAC.00944-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance Mechanisms in an In Vitro-Selected Amoxicillin-Resistant Strain of Helicobacter pylori Edgie-Mark A. Co and Neal L. Schiller Antimicrob. Agents Chemother. December 2006 50: 4174-4176; published ahead of print September 25, 2006, doi:10.1128/AAC.00759-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Environment of Acquired blaACC-1 ß-Lactamase Gene in Enterobacteriaceae Isolates A. Doloy, C. Verdet, V. Gautier, D. Decré, E. Ronco, A. Hammami, A. Philippon, and G. Arlet Antimicrob. Agents Chemother. December 2006 50: 4177-4181; published ahead of print September 18, 2006, doi:10.1128/AAC.00619-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Analysis of a Chromosome-Carried erm(B) Gene and Its Flanking Insertion Points in Lactobacillus johnsonii G41 Ana Belén Flórez, Mohammed Salim Ammor, Susana Delgado, and Baltasar Mayo Antimicrob. Agents Chemother. December 2006 50: 4189-4190; published ahead of print September 25, 2006, doi:10.1128/AAC.00657-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Multidrug-Resistant Klebsiella pneumoniae Isolates Producing VIM-4 Metallo-ß-Lactamase, CTX-M-15 Extended-Spectrum ß-Lactamase, and CMY-4 AmpC ß-Lactamase in a Tunisian University Hospital Sonia Ktari, Guillaume Arlet, Basma Mnif, Valérie Gautier, Fouzia Mahjoubi, Mounir Ben Jmeaa, Mounir Bouaziz, and Adnane Hammami Antimicrob. Agents Chemother. December 2006 50: 4198-4201; published ahead of print October 2, 2006, doi:10.1128/AAC.00663-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Emergence of Resistance to Linezolid during Linezolid Therapy of an Enterococcus faecium Infection Jamela Seedat, Günther Zick, Ingo Klare, Carola Konstabel, Norbert Weiler, and Hany Sahly Antimicrob. Agents Chemother. December 2006 50: 4217-4219; published ahead of print September 18, 2006, doi:10.1128/AAC.00518-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Epidemiology of VIM-4 Metallo-ß-Lactamase-Producing Pseudomonas sp. Isolates in Hungary Balázs Libisch, Mónika Muzslay, Mária Gacs, János Minárovits, Márta Knausz, Joseph Watine, Gábor Ternák, Éva Kenéz, Ildikó Kustos, László Rókusz, Klára Széles, Boglárka Balogh, and Miklós Füzi Antimicrob. Agents Chemother. December 2006 50: 4220-4223; published ahead of print September 25, 2006, doi:10.1128/AAC.00300-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

qnrA in CTX-M-Producing Escherichia coli Isolates from France Jean-Philippe Lavigne, Hélène Marchandin, Julien Delmas, Nicole Bouziges, Evelyne Lecaillon, Laurent Cavalie, Hélène Jean-Pierre, Richard Bonnet, and Albert Sotto Antimicrob. Agents Chemother. December 2006 50: 4224-4228; published ahead of print September 18, 2006, doi:10.1128/AAC.00904-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Antifungal Effects on Metabolite Profiles of Medically Important Yeast Species Measured by Nuclear Magnetic Resonance Spectroscopy Muireann Coen, Jennifer Bodkin, Damla Power, William A. Bubb, Uwe Himmelreich, Philip W. Kuchel, and Tania C. Sorrell Antimicrob. Agents Chemother. December 2006 50: 4018-4026; published ahead of print September 18, 2006, doi:10.1128/AAC.00439-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the Novel Oxazolidinones DA-7867 and DA-7157 against Rapidly and Slowly Growing Mycobacteria Lucio Vera-Cabrera, Barbara A. Brown-Elliott, Richard J. Wallace, Jr., Jorge Ocampo-Candiani, Oliverio Welsh, Sung Hak Choi, and Carmen A. Molina-Torres Antimicrob. Agents Chemother. December 2006 50: 4027-4029; published ahead of print October 2, 2006, doi:10.1128/AAC.00763-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characteristics and In Vitro Susceptibility to Antimicrobial Agents, Including the Des-Fluoro(6) Quinolone DX-619, of Panton-Valentine Leucocidin-Positive Methicillin-Resistant Staphylococcus aureus Isolates from the Community and Hospitals Tatsuo Yamamoto, Soshi Dohmae, Kohei Saito, Taketo Otsuka, Tomomi Takano, Megumi Chiba, Katsuko Fujikawa, and Mayumi Tanaka Antimicrob. Agents Chemother. December 2006 50: 4077-4086; published ahead of print October 16, 2006, doi:10.1128/AAC.00847-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Acyl-Substituted Dermaseptin S4 Derivatives with Improved Bactericidal Properties, Including on Oral Microflora Y. Porat, K. Marynka, A. Tam, D. Steinberg, and A. Mor Antimicrob. Agents Chemother. December 2006 50: 4153-4160; published ahead of print October 16, 2006, doi:10.1128/AAC.00750-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of DX-619 Compared to Other Agents against Viridans Group Streptococci, Streptococcus bovis, and Cardiobacterium hominis Klaudia Kosowska-Shick, Kathy Smith, Tatiana Bogdanovich, Lois M. Ednie, Ronald N. Jones, and Peter C. Appelbaum Antimicrob. Agents Chemother. December 2006 50: 4191-4194; published ahead of print October 16, 2006, doi:10.1128/AAC.01110-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Bactericidal Activities of Daptomycin and Vancomycin against Glycopeptide-Intermediate Staphylococcus aureus (GISA) and Heterogeneous GISA Isolates Mandy Wootton, Alasdair P. MacGowan, and Timothy R. Walsh Antimicrob. Agents Chemother. December 2006 50: 4195-4197; published ahead of print October 16, 2006, doi:10.1128/AAC.00678-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin Lorraine Jones-Brando, John D'Angelo, Gary H. Posner, and Robert Yolken Antimicrob. Agents Chemother. December 2006 50: 4206-4208; published ahead of print October 23, 2006, doi:10.1128/AAC.00793-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Susceptibilities of the Species of the Pseudallescheria boydii Complex Fèlix Gilgado, Carolina Serena, Josep Cano, Josepa Gené, and Josep Guarro Antimicrob. Agents Chemother. December 2006 50: 4211-4213; published ahead of print October 2, 2006, doi:10.1128/AAC.00981-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacokinetics of Itraconazole and Hydroxyitraconazole in Healthy Subjects after Single and Multiple Doses of a Novel Formulation J. W. Mouton, A. van Peer, K. de Beule, A. Van Vliet, J. P. Donnelly, and P. A. Soons Antimicrob. Agents Chemother. December 2006 50: 4096-4102; published ahead of print September 18, 2006, doi:10.1128/AAC.00630-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of CS-023 (RO4908463), a Novel Parenteral Carbapenem, in Healthy Male Caucasian Volunteers Takahiro Shibayama, Yoko Matsushita, Takashi Hirota, Toshihiko Ikeda, and Shogo Kuwahara Antimicrob. Agents Chemother. December 2006 50: 4186-4188; published ahead of print October 16, 2006, doi:10.1128/AAC.00494-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Utility of Alkylaminoquinolinyl Methanols as New Antimalarial Drugs G. S. Dow, T. N. Heady, A. K. Bhattacharjee, D. Caridha, L. Gerena, M. Gettayacamin, C. A. Lanteri, N. Obaldia, III, N. Roncal, T. Shearer, P. L. Smith, A. Tungtaeng, L. Wolf, M. Cabezas, D. Yourick, and K. S. Smith Antimicrob. Agents Chemother. December 2006 50: 4132-4143; published ahead of print September 11, 2006, doi:10.1128/AAC.00631-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Clonal Spread of Macrolide- and Tetracycline-Resistant [erm(A) tet(O)] emm77 Streptococcus pyogenes Isolates in Italy and Norway Claudio Palmieri, Manuela Vecchi, Pia Littauer, Arnfinn Sundsfjord, Pietro E. Varaldo, and Bruna Facinelli Antimicrob. Agents Chemother. December 2006 50: 4229-4230; published ahead of print October 16, 2006, doi:10.1128/AAC.00943-06 [Full Text] [PDF] [Reprints and Permissions]

Defining the Dosage Units for Colistin Methanesulfonate: Urgent Need for International Harmonization Jian Li, Roger L. Nation, John D. Turnidge, and Matthew E. Falagas Antimicrob. Agents Chemother. December 2006 50: 4231-4232; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.