Contents: February 2006, Volume 50, Issue 2        Clinical Therapeutics        Experimental Therapeutics        Mechanisms of Resistance        Mechanisms of Action        Chemistry; Biosynthesis        Antiviral Agents        Susceptibility        Pharmacology        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Clinical Therapeutics:

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Low Levels of Pyrazinamide and Ethambutol in Children with Tuberculosis and Impact of Age, Nutritional Status, and Human Immunodeficiency Virus Infection S. M. Graham, D. J. Bell, S. Nyirongo, R. Hartkoorn, S. A. Ward, and E. M. Molyneux Antimicrob. Agents Chemother. February 2006 50: 407-413; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bloodstream Infections Caused by Extended-Spectrum-ß-Lactamase-Producing Klebsiella pneumoniae: Risk Factors, Molecular Epidemiology, and Clinical Outcome Mario Tumbarello, Teresa Spanu, Maurizio Sanguinetti, Rita Citton, Eva Montuori, Fiammetta Leone, Giovanni Fadda, and Roberto Cauda Antimicrob. Agents Chemother. February 2006 50: 498-504; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics, Safety, and Efficacy of Posaconazole in Patients with Persistent Febrile Neutropenia or Refractory Invasive Fungal Infection A. J. Ullmann, O. A. Cornely, A. Burchardt, R. Hachem, D. P. Kontoyiannis, K. Töpelt, R. Courtney, D. Wexler, G. Krishna, M. Martinho, G. Corcoran, and I. Raad Antimicrob. Agents Chemother. February 2006 50: 658-666; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Evaluation of Macrolide-Resistant Mycoplasma pneumoniae Satowa Suzuki, Tsutomu Yamazaki, Mitsuo Narita, Norio Okazaki, Isao Suzuki, Tomoaki Andoh, Mayumi Matsuoka, Tsuyoshi Kenri, Yoshichika Arakawa, and Tsuguo Sasaki Antimicrob. Agents Chemother. February 2006 50: 709-712; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Hexadecylphosphocholine (Miltefosine) Has Broad-Spectrum Fungicidal Activity and Is Efficacious in a Mouse Model of Cryptococcosis Fred Widmer, Lesley C. Wright, Daniel Obando, Rosemary Handke, Ranjini Ganendren, David H. Ellis, and Tania C. Sorrell Antimicrob. Agents Chemother. February 2006 50: 414-421; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Amphotericin B and Micafungin Combination on Survival, Histopathology, and Fungal Burden in Experimental Aspergillosis in the p47phox–/– Mouse Model of Chronic Granulomatous Disease Carly G. Dennis, William R. Greco, Yseult Brun, Richard Youn, Harry K. Slocum, Ralph J. Bernacki, Russell Lewis, Nathan Wiederhold, Steven M. Holland, Ruta Petraitiene, Thomas J. Walsh, and Brahm H. Segal Antimicrob. Agents Chemother. February 2006 50: 422-427; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Activity of Amphotericin B Deoxycholate Is Associated with Peak Plasma Concentrations in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis Nathan P. Wiederhold, Vincent H. Tam, Jingduan Chi, Randall A. Prince, Dimitrios P. Kontoyiannis, and Russell E. Lewis Antimicrob. Agents Chemother. February 2006 50: 469-473; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Immunoglobulin G Recognizing Fibrinogen-Binding Surface Proteins Is Protective against both Staphylococcus aureus and Staphylococcus epidermidis Infections In Vivo John H. Vernachio, Arnold S. Bayer, Brenda Ames, Dawn Bryant, Bradley D. Prater, Peter J. Syribeys, Elena L. Gorovits, and Joseph M. Patti Antimicrob. Agents Chemother. February 2006 50: 511-518; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Linezolid in Prophylaxis against Experimental Aortic Valve Endocarditis Due to Streptococcus oralis or Enterococcus faecalis George Athanassopoulos, Angelos Pefanis, Vissaria Sakka, Dimitrios Iliopoulos, Despina Perrea, and Helen Giamarellou Antimicrob. Agents Chemother. February 2006 50: 654-657; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic-Pharmacodynamic Comparison of Amphotericin B (AMB) and Two Lipid-Associated AMB Preparations, Liposomal AMB and AMB Lipid Complex, in Murine Candidiasis Models D. Andes, N. Safdar, K. Marchillo, and R. Conklin Antimicrob. Agents Chemother. February 2006 50: 674-684; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Quinolones against Secondary Pneumococcal Pneumonia after Influenza Virus Infection in Mice Katsuhiko Hayashi, Shin-etsu Kadowaki, Masaya Takei, and Hideyuki Fukuda Antimicrob. Agents Chemother. February 2006 50: 748-751; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters Armin Stucki, Peter Gerber, Fernando Acosta, Marianne Cottagnoud, and Philippe Cottagnoud Antimicrob. Agents Chemother. February 2006 50: 770-773; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pulsatile Delivery of Clarithromycin Alone or in Combination with Amoxicillin against Streptococcus pneumoniae Kimberly D. Leuthner, Chrissy M. Cheung, and Michael J. Rybak Antimicrob. Agents Chemother. February 2006 50: 813-816; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Novel Mechanism of Antibiotic Resistance Originating in Vancomycin-Intermediate Staphylococcus aureus Longzhu Cui, Akira Iwamoto, Jian-Qi Lian, Hui-min Neoh, Toshiki Maruyama, Yataro Horikawa, and Keiichi Hiramatsu Antimicrob. Agents Chemother. February 2006 50: 428-438; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations Conferring Aminoglycoside and Spectinomycin Resistance in Borrelia burgdorferi Daniel Criswell, Virginia L. Tobiason, J. Stephen Lodmell, and D. Scott Samuels Antimicrob. Agents Chemother. February 2006 50: 445-452; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aspergillus fumigatus C-5 Sterol Desaturases Erg3A and Erg3B: Role in Sterol Biosynthesis and Antifungal Drug Susceptibility Laura Alcazar-Fuoli, Emilia Mellado, Guillermo Garcia-Effron, Maria J. Buitrago, Jordi F. Lopez, Joan O. Grimalt, J. Manuel Cuenca-Estrella, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. February 2006 50: 453-460; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Two-Component Regulatory System mtrAB Is Required for Morphotypic Multidrug Resistance in Mycobacterium avium Gerard A. Cangelosi, Julie S. Do, Robert Freeman, John G. Bennett, Makeda Semret, and Marcel A. Behr Antimicrob. Agents Chemother. February 2006 50: 461-468; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Malaria Parasites Can Develop Stable Resistance to Artemisinin but Lack Mutations in Candidate Genes atp6 (Encoding the Sarcoplasmic and Endoplasmic Reticulum Ca2+ ATPase), tctp, mdr1, and cg10 A. Afonso, P. Hunt, S. Cheesman, A. C. Alves, C. V. Cunha, V. do Rosário, and P. Cravo Antimicrob. Agents Chemother. February 2006 50: 480-489; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diagnostic PCR Analysis of the Occurrence of Methicillin and Tetracycline Resistance Genes among Staphylococcus aureus Isolates from Phase 3 Clinical Trials of Tigecycline for Complicated Skin and Skin Structure Infections C. Hal Jones, Margareta Tuckman, Anita Y. M. Howe, Mark Orlowski, Stanley Mullen, Karen Chan, and Patricia A. Bradford Antimicrob. Agents Chemother. February 2006 50: 505-510; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of the Autolytic System by Vancomycin Causes Mimicry of Vancomycin-Intermediate Staphylococcus aureus-Type Resistance, Cell Concentration Dependence of the MIC, and Antibiotic Tolerance in Vancomycin-Susceptible S. aureus Krzysztof Sieradzki and Alexander Tomasz Antimicrob. Agents Chemother. February 2006 50: 527-533; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Horizontal Transfer of blaCMY-Bearing Plasmids among Clinical Escherichia coli and Klebsiella pneumoniae Isolates and Emergence of Cefepime-Hydrolyzing CMY-19 Jun-ichi Wachino, Hiroshi Kurokawa, Satowa Suzuki, Kunikazu Yamane, Naohiro Shibata, Kouji Kimura, Yasuyoshi Ike, and Yoshichika Arakawa Antimicrob. Agents Chemother. February 2006 50: 534-541; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluconazole Treatment Is Effective against a Candida albicans erg3/erg3 Mutant In Vivo Despite In Vitro Resistance Taiga Miyazaki, Yoshitsugu Miyazaki, Koichi Izumikawa, Hiroshi Kakeya, Shunichi Miyakoshi, John E. Bennett, and Shigeru Kohno Antimicrob. Agents Chemother. February 2006 50: 580-586; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Transfer of the vanA Resistance Gene from an Enterococcus faecium Isolate of Animal Origin to an E. faecium Isolate of Human Origin in the Intestines of Human Volunteers Camilla H. Lester, Niels Frimodt-Møller, Thomas Lund Sørensen, Dominique L. Monnet, and Anette M. Hammerum Antimicrob. Agents Chemother. February 2006 50: 596-599; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of the Extended 4 Domain of Staphylococcus aureus Gyrase A Protein in Determining Low Sensitivity to Quinolones Jacob Strahilevitz, Ari Robicsek, and David C. Hooper Antimicrob. Agents Chemother. February 2006 50: 600-606; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of DHA-1-Producing Klebsiella spp. in the Parisian Region: Genetic Organization of the ampC and ampR Genes Originating from Morganella morganii Charlotte Verdet, Yahia Benzerara, Valérie Gautier, Olivier Adam, Zahia Ould-Hocine, and Guillaume Arlet Antimicrob. Agents Chemother. February 2006 50: 607-617; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CMY-16, a Novel Acquired AmpC-Type ß-Lactamase of the CMY/LAT Lineage in Multifocal Monophyletic Isolates of Proteus mirabilis from Northern Italy Marco M. D'Andrea, Elisabetta Nucleo, Francesco Luzzaro, Tommaso Giani, Roberta Migliavacca, Francesca Vailati, Vesselina Kroumova, Laura Pagani, and Gian Maria Rossolini Antimicrob. Agents Chemother. February 2006 50: 618-624; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Involvement of the Putative ATP-Dependent Efflux Proteins PatA and PatB in Fluoroquinolone Resistance of a Multidrug-Resistant Mutant of Streptococcus pneumoniae Estelle Marrer, Karen Schad, Andreas T. Satoh, Malcolm G. P. Page, Maggie M. Johnson, and Laura J. V. Piddock Antimicrob. Agents Chemother. February 2006 50: 685-693; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Tetracycline Resistance Genes in Actinobacillus pleuropneumoniae Isolates from Spain Mónica Blanco, César B. Gutiérrez-Martin, Elías F. Rodríguez-Ferri, Marilyn C. Roberts, and Jesús Navas Antimicrob. Agents Chemother. February 2006 50: 702-708; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Prediction of the Evolution of Ceftazidime Resistance in Extended-Spectrum ß-Lactamase CTX-M-9 J. Delmas, F. Robin, F. Carvalho, C. Mongaret, and R. Bonnet Antimicrob. Agents Chemother. February 2006 50: 731-738; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Occurrence of OXA-58-Like Carbapenemases in Acinetobacter spp. Collected over 10 Years in Three Continents Juliana Coelho, Neil Woodford, Mariya Afzal-Shah, and David Livermore Antimicrob. Agents Chemother. February 2006 50: 756-758; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes Klaudia Kosowska-Shick, Catherine Clark, Kim Credito, Pamela McGhee, Bonifacio Dewasse, Tatiana Bogdanovich, and Peter C. Appelbaum Antimicrob. Agents Chemother. February 2006 50: 765-769; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New TEM-Derived Extended-Spectrum ß-Lactamase and Its Genomic Context in Plasmids from Salmonella enterica Serovar Derby Isolates from Uruguay Rafael Vignoli, Nicolas F. Cordeiro, Virginia García, María Inés Mota, Laura Betancor, Pablo Power, José A. Chabalgoity, Felipe Schelotto, Gabriel Gutkind, and Juan A. Ayala Antimicrob. Agents Chemother. February 2006 50: 781-784; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Enterobacteriaceae Isolates Producing CTX-M Extended-Spectrum ß-Lactamase in Austria Alexandra Eisner, Elizabeth J. Fagan, Gebhard Feierl, Harald H. Kessler, Egon Marth, David M. Livermore, and Neil Woodford Antimicrob. Agents Chemother. February 2006 50: 785-787; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

PCR Classification of CTX-M-Type ß-Lactamase Genes Identified in Clinically Isolated Gram-Negative Bacilli in Japan Naohiro Shibata, Hiroshi Kurokawa, Yohei Doi, Tetsuya Yagi, Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Kouji Kimura, Satoshi Ishikawa, Haru Kato, Yoshiyuki Ozawa, Keigo Shibayama, Kumiko Kai, Toshifumi Konda, and Yoshichika Arakawa Antimicrob. Agents Chemother. February 2006 50: 791-795; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In117, an Unusual In0-Like Class 1 Integron Containing CR1 and blaCTX-M-2 and Associated with a Tn21-Like Element Aránzazu Valverde, Rafael Cantón, Juan Carlos Galán, Patrice Nordmann, Fernando Baquero, and Teresa M. Coque Antimicrob. Agents Chemother. February 2006 50: 799-802; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Streptococcus pyogenes Isolates with High-Level Macrolide Resistance and Reduced Susceptibility to Telithromycin Associated with 23S rRNA Mutations David J. Farrell, Jemma Shackcloth, Karen A. Barbadora, and Michael D. Green Antimicrob. Agents Chemother. February 2006 50: 817-818; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Rifalazil Pretreatment of Mammalian Cell Cultures Prevents Subsequent Chlamydia Infection Robert J. Suchland, Kara Brown, David M. Rothstein, and Walter E. Stamm Antimicrob. Agents Chemother. February 2006 50: 439-444; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Properties of Dermaseptin S4 Derivatives under Extreme Incubation Conditions Tali Rydlo, Shahar Rotem, and Amram Mor Antimicrob. Agents Chemother. February 2006 50: 490-497; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discovery of FabH/FabF Inhibitors from Natural Products Katherine Young, Hiranthi Jayasuriya, John G. Ondeyka, Kithsiri Herath, Chaowei Zhang, Srinivas Kodali, Andrew Galgoci, Ronald Painter, Vickie Brown-Driver, Robert Yamamoto, Lynn L. Silver, Yingcong Zheng, Judith I. Ventura, Janet Sigmund, Sookhee Ha, Angela Basilio, Francisca Vicente, José Rubén Tormo, Fernando Pelaez, Phil Youngman, Doris Cully, John F. Barrett, Dennis Schmatz, Sheo B. Singh, and Jun Wang Antimicrob. Agents Chemother. February 2006 50: 519-526; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Apigenin on gtf Gene Expression in Streptococcus mutans UA159 Hyun Koo, Jennifer Seils, Jacqueline Abranches, Robert A. Burne, William H. Bowen, and Robert G. Quivey, Jr. Antimicrob. Agents Chemother. February 2006 50: 542-546; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

3,5-Dioxopyrazolidines, Novel Inhibitors of UDP-N- Acetylenolpyruvylglucosamine Reductase (MurB) with Activity against Gram-Positive Bacteria Youjun Yang, Anatoly Severin, Rajiv Chopra, Girija Krishnamurthy, Guy Singh, William Hu, David Keeney, Kristine Svenson, Peter J. Petersen, Pornpen Labthavikul, David M. Shlaes, Beth A. Rasmussen, Amedeo A. Failli, Jay S. Shumsky, Kristina M. K. Kutterer, Adam Gilbert, and Tarek S. Mansour Antimicrob. Agents Chemother. February 2006 50: 556-564; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Loss of the Homotypic Fusion and Vacuole Protein Sorting or Golgi-Associated Retrograde Protein Vesicle Tethering Complexes Results in Gentamicin Sensitivity in the Yeast Saccharomyces cerevisiae Mark C. Wagner, Elizabeth E. Molnar, Bruce A. Molitoris, and Mark G. Goebl Antimicrob. Agents Chemother. February 2006 50: 587-595; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Quinolones Induce Partial or Total Loss of Pathogenicity Islands in Uropathogenic Escherichia coli by SOS-Dependent or -Independent Pathways, Respectively S. M. Soto, M. T. Jimenez de Anta, and J. Vila Antimicrob. Agents Chemother. February 2006 50: 649-653; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rational Design of Anticytoadherence Inhibitors for Plasmodium falciparum Based on the Crystal Structure of Human Intercellular Adhesion Molecule 1 Matthias Dormeyer, Yvonne Adams, Bernd Kramer, Srabasti Chakravorty, Man Tsuey Tse, Stefano Pegoraro, Lisa Whittaker, Michael Lanzer, and Alister Craig Antimicrob. Agents Chemother. February 2006 50: 724-730; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Doxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice Masaki Fujita, Qing Ye, Hiroshi Ouchi, Eiji Harada, Ichiro Inoshima, Kazuyoshi Kuwano, and Yoichi Nakanishi Antimicrob. Agents Chemother. February 2006 50: 739-743; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Candida parapsilosis Mitochondrial Respiratory Pathways Enhances Susceptibility to Caspofungin Georgios Chamilos, Russell E. Lewis, and Dimitrios P. Kontoyiannis Antimicrob. Agents Chemother. February 2006 50: 744-747; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trematocidal Activity of Praziquantel and Artemisinin Derivatives: In Vitro and In Vivo Investigations with Adult Echinostoma caproni Jennifer Keiser, Reto Brun, Bernard Fried, and Jürg Utzinger Antimicrob. Agents Chemother. February 2006 50: 803-805; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus Inshad Ali Khan, Zahid Mehmood Mirza, Ashwani Kumar, Vijeshwar Verma, and Ghulam Nabi Qazi Antimicrob. Agents Chemother. February 2006 50: 810-812; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Novel Compounds Active against Leishmania major Stephanie St. George, Jeanette V. Bishop, Richard G. Titus, and Claude P. Selitrennikoff Antimicrob. Agents Chemother. February 2006 50: 474-479; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Inhibition of Human Immunodeficiency Virus Type 1 Replication in Latently Infected Cells by a Novel IB Kinase Inhibitor Ann Florence B. Victoriano, Kaori Asamitsu, Yurina Hibi, Kenichi Imai, Nina G. Barzaga, and Takashi Okamoto Antimicrob. Agents Chemother. February 2006 50: 547-555; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Yeast Cell-Based Assay To Screen for Inhibitors of Human Cytomegalovirus Protease in a High-Throughput Format Valérie Cottier, Alcide Barberis, and Urs Lüthi Antimicrob. Agents Chemother. February 2006 50: 565-571; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antiretroviral Activity and In Vitro Toxicity Profile of SPD754, a New Deoxycytidine Nucleoside Reverse Transcriptase Inhibitor for Treatment of Human Immunodeficiency Virus Infection Z. Gu, B. Allard, J. M. de Muys, J. Lippens, R. F. Rando, N. Nguyen-Ba, C. Ren, P. McKenna, D. L. Taylor, and R. C. Bethell Antimicrob. Agents Chemother. February 2006 50: 625-631; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discordances between Interpretation Algorithms for Genotypic Resistance to Protease and Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Are Subtype Dependent Joke Snoeck, Rami Kantor, Robert W. Shafer, Kristel Van Laethem, Koen Deforche, Ana Patricia Carvalho, Brian Wynhoven, Marcelo A. Soares, Patricia Cane, John Clarke, Candice Pillay, Sunee Sirivichayakul, Koya Ariyoshi, Africa Holguin, Hagit Rudich, Rosangela Rodrigues, Maria Belen Bouzas, Françoise Brun-Vézinet, Caroline Reid, Pedro Cahn, Luis Fernando Brigido, Zehava Grossman, Vincent Soriano, Wataru Sugiura, Praphan Phanuphak, Lynn Morris, Jonathan Weber, Deenan Pillay, Amilcar Tanuri, Richard P. Harrigan, Ricardo Camacho, Jonathan M. Schapiro, David Katzenstein, and Anne-Mieke Vandamme Antimicrob. Agents Chemother. February 2006 50: 694-701; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Preclinical Testing of Nonoxynol-9 as Potential Anti-Human Immunodeficiency Virus Microbicide: a Retrospective Analysis of Results from Five Laboratories Brigitte E. Beer, Gustavo F. Doncel, Fred C. Krebs, Robin J. Shattock, Patricia S. Fletcher, Robert W. Buckheit, Jr., Karen Watson, Charlene S. Dezzutti, James E. Cummins, Ena Bromley, Nicola Richardson-Harman, Luke A. Pallansch, Carol Lackman-Smith, Clay Osterling, Marie Mankowski, Shendra R. Miller, Bradley J. Catalone, Patricia A. Welsh, Mary K. Howett, Brian Wigdahl, Jim A. Turpin, and Patricia Reichelderfer Antimicrob. Agents Chemother. February 2006 50: 713-723; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection David A. Kocisko, Winslow S. Caughey, Richard E. Race, Grant Roper, Byron Caughey, and John D. Morrey Antimicrob. Agents Chemother. February 2006 50: 759-761; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Practical Preclinical Model for Assessing the Potential for Unconjugated Hyperbilirubinemia Produced by Human Immunodeficiency Virus Protease Inhibitors Dale J. Kempf, Jeffrey F. Waring, David C. Morfitt, Paige Werner, Brian Ebert, Michael Mitten, Bach Nguyen, John T. Randolph, David A. DeGoey, Larry L. Klein, and Kennan Marsh Antimicrob. Agents Chemother. February 2006 50: 762-764; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Ribavirin and Glucocorticoid Treatment in a Mouse Model of Human Metapneumovirus Infection Marie-Ève Hamelin, Gregory A. Prince, and Guy Boivin Antimicrob. Agents Chemother. February 2006 50: 774-777; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Nonmolecular Test for Detection of Low-Level Resistance to Fluoroquinolones in Streptococcus pneumoniae Emmanuelle Varon, Serge Houssaye, Sophie Grondin, Laurent Gutmann the Groupe des Observatoires de la Résistance du Pneumocoque Antimicrob. Agents Chemother. February 2006 50: 572-579; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potencies of Human Immunodeficiency Virus Protease Inhibitors In Vitro against Plasmodium falciparum and In Vivo against Murine Malaria Katherine T. Andrews, David P. Fairlie, Praveen K. Madala, John Ray, David M. Wyatt, Petrina M. Hilton, Lewis A. Melville, Lynette Beattie, Donald L. Gardiner, Robert C. Reid, Martin J. Stoermer, Tina Skinner-Adams, Colin Berry, and James S. McCarthy Antimicrob. Agents Chemother. February 2006 50: 639-648; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potentiation of Catechin Gallate-Mediated Sensitization of Staphylococcus aureus to Oxacillin by Nongalloylated Catechins Paul D. Stapleton, Saroj Shah, Yukihiko Hara, and Peter W. Taylor Antimicrob. Agents Chemother. February 2006 50: 752-755; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Antimicrobial Susceptibilities of Campylobacter jejuni Isolates from Poultry from Alberta, Canada Veronica N. Kos, Monika Keelan, and Diane E. Taylor Antimicrob. Agents Chemother. February 2006 50: 778-780; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of DX-619, a Novel Des-Fluoro(6) Quinolone, against a Panel of Streptococcus pneumoniae Mutants with Characterized Resistance Mechanisms Paul A. Wickman, Ellen Smith Moland, Jennifer A. Black, and Kenneth S. Thomson Antimicrob. Agents Chemother. February 2006 50: 796-798; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

In Vitro Bactericidal Activity of Human ß-Defensin 3 against Multidrug-Resistant Nosocomial Strains Giuseppantonio Maisetta, Giovanna Batoni, Semih Esin, Walter Florio, Daria Bottai, Flavia Favilli, and Mario Campa Antimicrob. Agents Chemother. February 2006 50: 806-809; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Doripenem against Pseudomonas aeruginosa and Burkholderia cepacia Isolates from both Cystic Fibrosis and Non-Cystic Fibrosis Patients M. M. Traczewski and S. D. Brown Antimicrob. Agents Chemother. February 2006 50: 819-821; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Safety and Pharmacokinetics of Intravenous Anidulafungin in Children with Neutropenia at High Risk for Invasive Fungal Infections Daniel K. Benjamin, Jr., Timothy Driscoll, Nita L. Seibel, Corina E. Gonzalez, Maureen M. Roden, Rahki Kilaru, Kay Clark, James A. Dowell, Jennifer Schranz, and Thomas J. Walsh Antimicrob. Agents Chemother. February 2006 50: 632-638; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Enfuvirtide in Patients Treated in Typical Routine Clinical Settings Hartmut Stocker, Charlotte Kloft, Nele Plock, Antje Breske, Guido Kruse, Christian Herzmann, Hubert Schulbin, Peter Kreckel, Christoph Weber, Frank Goebel, Joerg Roeling, Schlomo Staszewski, Andreas Plettenberg, Christiane Moecklinghoff, Keikawus Arastéh, and Michael Kurowski Antimicrob. Agents Chemother. February 2006 50: 667-673; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tissue Penetration of Telavancin after Intravenous Administration in Healthy Subjects Heather K. Sun, Kenneth Duchin, Charles H. Nightingale, Jeng-Pyng Shaw, Julie Seroogy, and David P. Nicolau Antimicrob. Agents Chemother. February 2006 50: 788-790; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Evaluation of High- versus Standard-Dose Rifampin in Indonesian Patients with Pulmonary Tuberculosis Rovina Ruslami, Hanneke Nijland, Rob Aarnoutse, Bachti Alisjahbana, Arto Yuwono Soeroto, Suzanne Ewalds, and Reinout van Crevel Antimicrob. Agents Chemother. February 2006 50: 822-823; [Full Text] [PDF] [Reprints and Permissions]

Tularemia and Once-Daily Gentamicin Ali Hassoun, Richard Spera, and John Dunkel Antimicrob. Agents Chemother. February 2006 50: 824 [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Polymyxin B, Imipenem, and Rifampin against Multidrug-Resistant Acinetobacter baumannii D. W. Wareham, D. C. Bean, Carl M. Urban, and James J. Rahal Antimicrob. Agents Chemother. February 2006 50: 825-826; [Full Text] [PDF] [Reprints and Permissions]

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