AAC -- Table of Contents (April 1 2006, 50 [4])

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Contents: April 2006, Volume 50, Issue 4

       Minireviews

       Antiviral Agents

       Chemistry; Biosynthesis

       Mechanisms of Resistance

       Clinical Therapeutics

       Experimental Therapeutics

       Mechanisms of Action

       Pharmacology

       Susceptibility

       Biologic Response Modifiers

       Letters

Other Issues

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Minireviews:

ß-Lactamase Nomenclature
George A. Jacoby
Antimicrob. Agents Chemother. April 2006 50: 1123-1129;
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Antiviral Agents:

Maribavir Pharmacokinetics and the Effects of Multiple-Dose Maribavir on Cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-Acetyltransferase-2, and Xanthine Oxidase Activities in Healthy Adults
Joseph D. Ma, Anne N. Nafziger, Stephen A. Villano, Andrea Gaedigk, and Joseph S. Bertino, Jr.
Antimicrob. Agents Chemother. April 2006 50: 1130-1135;
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Triaryl Pyrazoline Compound Inhibits Flavivirus RNA Replication
Francesc Puig-Basagoiti, Mark Tilgner, Brett M. Forshey, Sean M. Philpott, Noel G. Espina, David E. Wentworth, Scott J. Goebel, Paul S. Masters, Barry Falgout, Ping Ren, David M. Ferguson, and Pei-Yong Shi
Antimicrob. Agents Chemother. April 2006 50: 1320-1329;
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Activity and Mechanism of Action of N-Methanocarbathymidine against Herpesvirus and Orthopoxvirus Infections
Mark N. Prichard, Kathy A. Keith, Debra C. Quenelle, and Earl R. Kern
Antimicrob. Agents Chemother. April 2006 50: 1336-1341;
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Phosphorothioate Oligonucleotides Inhibit Human Immunodeficiency Virus Type 1 Fusion by Blocking gp41 Core Formation
Andrew Vaillant, Jean-Marc Juteau, Hong Lu, Shuwen Liu, Carol Lackman-Smith, Roger Ptak, and Shibo Jiang
Antimicrob. Agents Chemother. April 2006 50: 1393-1401;
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Efficacy of Hospital Germicides against Adenovirus 8, a Common Cause of Epidemic Keratoconjunctivitis in Health Care Facilities
William A. Rutala, Jeffrey E. Peacock, Maria F. Gergen, Mark D. Sobsey, and David J. Weber
Antimicrob. Agents Chemother. April 2006 50: 1419-1424;
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Sialidase Fusion Protein as a Novel Broad-Spectrum Inhibitor of Influenza Virus Infection
Michael P. Malakhov, Laura M. Aschenbrenner, Donald F. Smee, Miles K. Wandersee, Robert W. Sidwell, Larisa V. Gubareva, Vasiliy P. Mishin, Frederick G. Hayden, Do Hyong Kim, Alice Ing, Erin R. Campbell, Mang Yu, and Fang Fang
Antimicrob. Agents Chemother. April 2006 50: 1470-1479;
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Preclinical Evaluation of Synthetic –2 RANTES as a Candidate Vaginal Microbicide To Target CCR5
Tina M. Kish-Catalone, Wuyuan Lu, Robert C. Gallo, and Anthony L. DeVico
Antimicrob. Agents Chemother. April 2006 50: 1497-1509;
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Substrate Envelope and Drug Resistance: Crystal Structure of RO1 in Complex with Wild-Type Human Immunodeficiency Virus Type 1 Protease
Moses Prabu-Jeyabalan, Nancy M. King, Ellen A. Nalivaika, Gabrielle Heilek-Snyder, Nick Cammack, and Celia A. Schiffer
Antimicrob. Agents Chemother. April 2006 50: 1518-1521;
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Ether Lipid Ester Derivatives of Cidofovir Inhibit Polyomavirus BK Replication In Vitro
Parmjeet Randhawa, Noush Afarin Farasati, Ron Shapiro, and Karl Y. Hostetler
Antimicrob. Agents Chemother. April 2006 50: 1564-1566;
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Chemistry; Biosynthesis:

Structure-Activity Relationships of Aminocoumarin-Type Gyrase and Topoisomerase IV Inhibitors Obtained by Combinatorial Biosynthesis
Ruth H. Flatman, Alessandra Eustaquio, Shu-Ming Li, Lutz Heide, and Anthony Maxwell
Antimicrob. Agents Chemother. April 2006 50: 1136-1142;
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Protease-Stable Polycationic Photosensitizer Conjugates between Polyethyleneimine and Chlorin(e6) for Broad-Spectrum Antimicrobial Photoinactivation
George P. Tegos, Masahiro Anbe, Changming Yang, Tatiana N. Demidova, Minahil Satti, Pawel Mroz, Sumbul Janjua, Faten Gad, and Michael R. Hamblin
Antimicrob. Agents Chemother. April 2006 50: 1402-1410;
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Mechanisms of Resistance:

Organization of Tn2610 Containing Two Transposition Modules
Akiko Takaya, Masato Watanabe, and Tomoko Yamamoto
Antimicrob. Agents Chemother. April 2006 50: 1143-1147;
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Overexpression of Candida albicans CDR1, CDR2, or MDR1 Does Not Produce Significant Changes in Echinocandin Susceptibility
K. Niimi, K. Maki, F. Ikeda, A. R. Holmes, E. Lamping, M. Niimi, B. C. Monk, and R. D. Cannon
Antimicrob. Agents Chemother. April 2006 50: 1148-1155;
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Distribution of Florfenicol Resistance Genes fexA and cfr among Chloramphenicol-Resistant Staphylococcus Isolates
Corinna Kehrenberg and Stefan Schwarz
Antimicrob. Agents Chemother. April 2006 50: 1156-1163;
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qnrB, Another Plasmid-Mediated Gene for Quinolone Resistance
George A. Jacoby, Kelley E. Walsh, Debra M. Mills, Victoria J. Walker, Herin Oh, Ari Robicsek, and David C. Hooper
Antimicrob. Agents Chemother. April 2006 50: 1178-1182;
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Staphylococcus aureus CcpA Affects Virulence Determinant Production and Antibiotic Resistance
Kati Seidl, Martin Stucki, Martin Ruegg, Christiane Goerke, Christiane Wolz, Llinos Harris, Brigitte Berger-Bächi, and Markus Bischoff
Antimicrob. Agents Chemother. April 2006 50: 1183-1194;
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Clinical and Economic Impact of Bacteremia with Extended- Spectrum-ß-Lactamase-Producing Enterobacteriaceae
Mitchell J. Schwaber, Shiri Navon-Venezia, Keith S. Kaye, Ronen Ben-Ami, David Schwartz, and Yehuda Carmeli
Antimicrob. Agents Chemother. April 2006 50: 1257-1262;
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MepR, a Repressor of the Staphylococcus aureus MATE Family Multidrug Efflux Pump MepA, Is a Substrate-Responsive Regulatory Protein
Glenn W. Kaatz, Carmen E. DeMarco, and Susan M. Seo
Antimicrob. Agents Chemother. April 2006 50: 1276-1281;
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In Vitro Analysis of ISEcp1B-Mediated Mobilization of Naturally Occurring ß-Lactamase Gene bla_CTX-M of Kluyvera ascorbata
Marie-Frédérique Lartigue, Laurent Poirel, Daniel Aubert, and Patrice Nordmann
Antimicrob. Agents Chemother. April 2006 50: 1282-1286;
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Novel Carbapenem-Hydrolyzing Oxacillinase OXA-62 from Pandoraea pnomenusa
Ines Schneider, Anne Marie Queenan, and Adolf Bauernfeind
Antimicrob. Agents Chemother. April 2006 50: 1330-1335;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of rpoB2 RNA Polymerase ß Subunit Gene to Rifampin Resistance in Nocardia Species
Jun Ishikawa, Kazuhiro Chiba, Haruyo Kurita, and Hiroyuki Satoh
Antimicrob. Agents Chemother. April 2006 50: 1342-1346;
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Involvement of the MexXY-OprM Efflux System in Emergence of Cefepime Resistance in Clinical Strains of Pseudomonas aeruginosa
Didier Hocquet, Patrice Nordmann, Farid El Garch, Ludovic Cabanne, and Patrick Plésiat
Antimicrob. Agents Chemother. April 2006 50: 1347-1351;
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Overexpression of the MDR1 Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in Candida albicans
Davina Hiller, Dominique Sanglard, and Joachim Morschhäuser
Antimicrob. Agents Chemother. April 2006 50: 1365-1371;
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Candida glabrata PDR1, a Transcriptional Regulator of a Pleiotropic Drug Resistance Network, Mediates Azole Resistance in Clinical Isolates and Petite Mutants
Huei-Fung Tsai, Anna A. Krol, Kelly E. Sarti, and John E. Bennett
Antimicrob. Agents Chemother. April 2006 50: 1384-1392;
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Comparative Analysis of Chromosome-Encoded Microcins
María Eloisa Poey, María F. Azpiroz, and Magela Laviña
Antimicrob. Agents Chemother. April 2006 50: 1411-1418;
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Genetic Structures at the Origin of Acquisition and Expression of the Carbapenem-Hydrolyzing Oxacillinase Gene bla_OXA-58 in Acinetobacter baumannii
Laurent Poirel and Patrice Nordmann
Antimicrob. Agents Chemother. April 2006 50: 1442-1448;
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In Vivo Selection of Fluoroquinolone-Resistant Escherichia coli Isolates Expressing Plasmid-Mediated Quinolone Resistance and Expanded-Spectrum ß-Lactamase
Laurent Poirel, Johann D. D. Pitout, Lucy Calvo, Jose-Manuel Rodriguez-Martinez, Deirdre Church, and Patrice Nordmann
Antimicrob. Agents Chemother. April 2006 50: 1525-1527;
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Gatifloxacin Resistance and Mutations in gyrA after Unsuccessful Helicobacter pylori Eradication in Japan
Toshihiro Nishizawa, Hidekazu Suzuki, Kumiko Kurabayashi, Tatsuhiro Masaoka, Hiroe Muraoka, Mikiji Mori, Eisuke Iwasaki, Intetsu Kobayashi, and Toshifumi Hibi
Antimicrob. Agents Chemother. April 2006 50: 1538-1540;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Autolytic Properties of Glycopeptide-Intermediate Staphylococcus aureus Mu50
Sugunya Utaida, Richard F. Pfeltz, R. K. Jayaswal, and B. J. Wilkinson
Antimicrob. Agents Chemother. April 2006 50: 1541-1545;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quadruple Mutations in Dihydrofolate Reductase of Plasmodium falciparum Isolates from Car Nicobar Island, India
Anwar Ahmed, Manoj K. Das, Vas Dev, Muheet A. Saifi, Wajihullah, and Yagya D. Sharma
Antimicrob. Agents Chemother. April 2006 50: 1546-1549;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Basis of Tetracycline and Minocycline Resistance in Potentially Probiotic Lactobacillus plantarum Strain CCUG 43738
Geert Huys, Klaas D'Haene, and Jean Swings
Antimicrob. Agents Chemother. April 2006 50: 1550-1551;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of First-Step Mutants among Levofloxacin-Susceptible Invasive Isolates of Streptococcus pneumoniae in the United States
Mathias W. R. Pletz, Ardaman P. Shergill, Lesley McGee, Bernard Beall, Cynthia G. Whitney, Keith P. Klugman for the Active Bacterial Core Surveillance Team
Antimicrob. Agents Chemother. April 2006 50: 1561-1563;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Induction of Daptomycin Heterogeneous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin
George Sakoulas, Jeff Alder, Claudie Thauvin-Eliopoulos, Robert C. Moellering, Jr., and George M. Eliopoulos
Antimicrob. Agents Chemother. April 2006 50: 1581-1585;
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Variability in the Region Downstream of the bla_CMY-2 ß-Lactamase Gene in Escherichia coli and Salmonella enterica Plasmids
Min-Su Kang, Thomas E. Besser, and Douglas R. Call
Antimicrob. Agents Chemother. April 2006 50: 1590-1593;
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New Real-Time PCR Assay Using Locked Nucleic Acid Probes To Assess Prevalence of ParC Mutations in Fluoroquinolone-Susceptible Streptococcus pneumoniae Isolates from France
Jean-Winoc Decousser, Imen Methlouthi, Patrick Pina, Anne Collignon, Pierre Allouch on behalf of the ColBVH Study Group
Antimicrob. Agents Chemother. April 2006 50: 1594-1598;
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Large Conjugative Plasmids from Clinical Strains of Salmonella enterica Serovar Virchow Contain a Class 2 Integron in Addition to Class 1 Integrons and Several Non-Integron-Associated Drug Resistance Determinants
Irene Rodríguez, M. Rosario Rodicio, M. Carmen Mendoza, and M. Cruz Martín
Antimicrob. Agents Chemother. April 2006 50: 1603-1607;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Comparing Gatifloxacin and Clarithromycin in Pneumonia Symptom Resolution and Process of Care
Nathan C. Dean, Paul Sperry, Matthew Wikler, Mary S. Suchyta, and Carol Hadlock
Antimicrob. Agents Chemother. April 2006 50: 1164-1169;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determinants of Rifampin, Isoniazid, Pyrazinamide, and Ethambutol Pharmacokinetics in a Cohort of Tuberculosis Patients
Helen McIlleron, Peter Wash, André Burger, Jennifer Norman, Peter I. Folb, and Pete Smith
Antimicrob. Agents Chemother. April 2006 50: 1170-1177;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Microflora Changes with Norfloxacin and Pivmecillinam in Women with Recurrent Urinary Tract Infection
Birgit Stattin Norinder, Ragnar Norrby, Ann-Chatrin Palmgren, Sofia Hollenberg, Ulla Eriksson, and Carl Erik Nord
Antimicrob. Agents Chemother. April 2006 50: 1528-1530;
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Ritonavir Increases Plasma Amprenavir (APV) Exposure to a Similar Extent when Coadministered with either Fosamprenavir or APV
Mary B. Wire, Katherine L. Baker, Lori S. Jones, Mark J. Shelton, Yu Lou, Greg J. Thomas, and M. Michelle Berrey
Antimicrob. Agents Chemother. April 2006 50: 1578-1580;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Good Clinical Outcomes but High Rates of Adverse Reactions during Linezolid Therapy for Serious Infections: a Proposed Protocol for Monitoring Therapy in Complex Patients
Emma Bishop, Sharmila Melvani, Benjamin P. Howden, Patrick G. P. Charles, and M. Lindsay Grayson
Antimicrob. Agents Chemother. April 2006 50: 1599-1602;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Real-Time Reverse Transcription-PCR Quantification of Cytokine mRNA Expression in Golden Syrian Hamster Infected with Leishmania infantum and Treated with a New Amphotericin B Formulation
S. Rama Iñiguez, M. A. Dea-Ayuela, J. A. Sanchez-Brunete, J. J. Torrado, J. M. Alunda, and F. Bolas-Fernández
Antimicrob. Agents Chemother. April 2006 50: 1195-1201;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nanodisk-Associated Amphotericin B Clears Leishmania major Cutaneous Infection in Susceptible BALB/c Mice
Keith G. Nelson, Jeanette V. Bishop, Robert O. Ryan, and Richard Titus
Antimicrob. Agents Chemother. April 2006 50: 1238-1244;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Microbiologic and Pharmacologic Evaluation of Experimental Compounds against Mycobacterium tuberculosis
Veronica Gruppo, Christine M. Johnson, Karen S. Marietta, Hataichanok Scherman, Erin E. Zink, Dean C. Crick, Linda B. Adams, Ian M. Orme, and Anne J. Lenaerts
Antimicrob. Agents Chemother. April 2006 50: 1245-1250;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Garenoxacin Treatment of Experimental Endocarditis Caused by Viridans Group Streptococci
Paloma Anguita-Alonso, Mark S. Rouse, Kerryl E. Piper, James M. Steckelberg, and Robin Patel
Antimicrob. Agents Chemother. April 2006 50: 1263-1267;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Using Bacteriophages To Reduce Formation of Catheter-Associated Biofilms by Staphylococcus epidermidis
John J. Curtin and Rodney M. Donlan
Antimicrob. Agents Chemother. April 2006 50: 1268-1275;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessment of the Paradoxical Effect of Caspofungin in Therapy of Candidiasis
Karl V. Clemons, Marife Espiritu, Rachana Parmar, and David A. Stevens
Antimicrob. Agents Chemother. April 2006 50: 1293-1297;
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Impact of Enterococcus faecalis on the Bactericidal Activities of Arbekacin, Daptomycin, Linezolid, and Tigecycline against Methicillin-Resistant Staphylococcus aureus in a Mixed-Pathogen Pharmacodynamic Model
Kerry L. LaPlante, Michael J. Rybak, Kimberly D. Leuthner, and Judy N. Chin
Antimicrob. Agents Chemother. April 2006 50: 1298-1303;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies
Deniz Tasdemir, Marcel Kaiser, Reto Brun, Vanessa Yardley, Thomas J. Schmidt, Fatma Tosun, and Peter Rüedi
Antimicrob. Agents Chemother. April 2006 50: 1352-1364;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of a New Cephalosporin, PPI-0903 (TAK-599), Active against Methicillin-Resistant Staphylococcus aureus in Murine Thigh and Lung Infection Models: Identification of an In Vivo Pharmacokinetic-Pharmacodynamic Target
D. Andes and W. A. Craig
Antimicrob. Agents Chemother. April 2006 50: 1376-1383;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multidimensional Volumetric Imaging of Pulmonary Infiltrates for Measuring Therapeutic Response to Antifungal Therapy in Experimental Invasive Pulmonary Aspergillosis
Vidmantas Petraitis, Ruta Petraitiene, Jeffrey Solomon, Amy M. Kelaher, Heidi A. Murray, Christine Mya-San, Avi K. Bhandary, Tin Sein, Nilo A. Avila, Algidas Basevicius, John Bacher, and Thomas J. Walsh
Antimicrob. Agents Chemother. April 2006 50: 1510-1517;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy of Aerosolized Nanostructured Itraconazole Formulations for Prevention of Invasive Pulmonary Aspergillosis
Barbara J. Hoeben, David S. Burgess, Jason T. McConville, Laura K. Najvar, Robert L. Talbert, Jay I. Peters, Nathan P. Wiederhold, Bradi L. Frei, John R. Graybill, Rosie Bocanegra, Kirk A. Overhoff, Prapasri Sinswat, Keith P. Johnston, and Robert O. Williams, III
Antimicrob. Agents Chemother. April 2006 50: 1552-1554;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activities of R207910 and Other Newer Antimicrobial Agents against Mycobacterium leprae in Mice
Baohong Ji, Aurélie Chauffour, Koen Andries, and Vincent Jarlier
Antimicrob. Agents Chemother. April 2006 50: 1558-1560;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequential or Combination Antifungal Therapy with Voriconazole and Liposomal Amphotericin B in a Guinea Pig Model of Invasive Aspergillosis
William R. Kirkpatrick, Brent J. Coco, and Thomas F. Patterson
Antimicrob. Agents Chemother. April 2006 50: 1567-1569;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Bac 32, a Novel Bacteriocin Widely Disseminated among Clinical Isolates of Enterococcus faecium
Takako Inoue, Haruyoshi Tomita, and Yasuyoshi Ike
Antimicrob. Agents Chemother. April 2006 50: 1202-1212;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gentamicin Causes Apoptosis at Low Concentrations in Renal LLC-PK₁ Cells Subjected to Electroporation
Hélène Servais, Yves Jossin, Françoise Van Bambeke, Paul M. Tulkens, and Marie-Paule Mingeot-Leclercq
Antimicrob. Agents Chemother. April 2006 50: 1213-1221;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class
Nagraj Mani, Christian H. Gross, Jonathan D. Parsons, Brian Hanzelka, Ute Müh, Steve Mullin, Yusheng Liao, Anne-Laure Grillot, Dean Stamos, Paul S. Charifson, and Trudy H. Grossman
Antimicrob. Agents Chemother. April 2006 50: 1228-1237;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Cecropin A-Melittin Hybrid Peptides against Colistin-Resistant Clinical Strains of Acinetobacter baumannii: Molecular Basis for the Differential Mechanisms of Action
José María Saugar, María Jesús Rodríguez-Hernández, Beatriz G. de la Torre, María Eugenia Pachón-Ibañez, María Fernández-Reyes, David Andreu, Jerónimo Pachón, and Luis Rivas
Antimicrob. Agents Chemother. April 2006 50: 1251-1256;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Time Course of Microbiologic Outcome and Gene Expression in Candida albicans during and following In Vitro and In Vivo Exposure to Fluconazole
A. Lepak, J. Nett, L. Lincoln, K. Marchillo, and D. Andes
Antimicrob. Agents Chemother. April 2006 50: 1311-1319;
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Screen for Inhibitors of the Coupled Transglycosylase-Transpeptidase of Peptidoglycan Biosynthesis in Escherichia coli
Vasanthi Ramachandran, B. Chandrakala, Vidya P. Kumar, Veeraraghavan Usha, Suresh M. Solapure, and Sunita M. de Sousa
Antimicrob. Agents Chemother. April 2006 50: 1425-1432;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Insights into In Vivo Activities of Lantibiotics from Gallidermin and Epidermin Mode-of-Action Studies
Raquel Regina Bonelli, Tanja Schneider, Hans-Georg Sahl, and Imke Wiedemann
Antimicrob. Agents Chemother. April 2006 50: 1449-1457;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center
Katherine S. Long, Lykke H. Hansen, Lene Jakobsen, and Birte Vester
Antimicrob. Agents Chemother. April 2006 50: 1458-1462;
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Adding Selectivity to Antimicrobial Peptides: Rational Design of a Multidomain Peptide against Pseudomonas spp.
Randal Eckert, Fengxia Qi, Daniel K. Yarbrough, Jian He, Maxwell H. Anderson, and Wenyuan Shi
Antimicrob. Agents Chemother. April 2006 50: 1480-1488;
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Binding of Neomycin-Class Aminoglycoside Antibiotics to Mutant Ribosomes with Alterations in the A Site of 16S rRNA
Sven N. Hobbie, Peter Pfister, Christian Bruell, Peter Sander, Boris François, Eric Westhof, and Erik C. Böttger
Antimicrob. Agents Chemother. April 2006 50: 1489-1496;
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The Antimicrobial Peptide Polyphemusin Localizes to the Cytoplasm of Escherichia coli following Treatment
Jon-Paul S. Powers, Morgan M. Martin, Danika L. Goosney, and Robert E. W. Hancock
Antimicrob. Agents Chemother. April 2006 50: 1522-1524;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Comparative Pharmacokinetics and Pharmacodynamic Target Attainment of Ertapenem in Normal-Weight, Obese, and Extremely Obese Adults
M. Chen, A. N. Nafziger, G. L. Drusano, L. Ma, and J. S. Bertino, Jr.
Antimicrob. Agents Chemother. April 2006 50: 1222-1227;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Tenofovir Disoproxil Fumarate and Ritonavir-Boosted Saquinavir Mesylate Administered Alone or in Combination at Steady State
Gregory E. Chittick, Jian Zong, M. Robert Blum, Jeffrey J. Sorbel, John A. Begley, Nathalie Adda, and Brian P. Kearney
Antimicrob. Agents Chemother. April 2006 50: 1304-1310;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impaired Target Site Penetration of Vancomycin in Diabetic Patients following Cardiac Surgery
Keso Skhirtladze, Doris Hutschala, Tatjana Fleck, Florian Thalhammer, Marek Ehrlich, Thomas Vukovich, Markus Müller, and Edda M. Tschernko
Antimicrob. Agents Chemother. April 2006 50: 1372-1375;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Voriconazole Therapeutic Drug Monitoring
J. Smith, N. Safdar, V. Knasinski, W. Simmons, S. M. Bhavnani, P. G. Ambrose, and D. Andes
Antimicrob. Agents Chemother. April 2006 50: 1570-1572;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Approach for High-Throughput Screening of Drug Activity on Plasmodium Liver Stages
Audrey Gego, Olivier Silvie, Jean-François Franetich, Khemaïs Farhati, Laurent Hannoun, Adrian J. F. Luty, Robert W. Sauerwein, Claude Boucheix, Eric Rubinstein, and Dominique Mazier
Antimicrob. Agents Chemother. April 2006 50: 1586-1589;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Evaluation of Amphotericin B Interpretive Breakpoints for Candida Bloodstream Isolates by Correlation with Therapeutic Outcome
Benjamin J. Park, Beth A. Arthington-Skaggs, Rana A. Hajjeh, Naureen Iqbal, Meral A. Ciblak, Wendy Lee-Yang, Mario D. Hairston, Maureen Phelan, Brian D. Plikaytis, Andre N. Sofair, Lee H. Harrison, Scott K. Fridkin, and David W. Warnock
Antimicrob. Agents Chemother. April 2006 50: 1287-1292;
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Effect of Farnesol on Staphylococcus aureus Biofilm Formation and Antimicrobial Susceptibility
M. A. Jabra-Rizk, T. F. Meiller, C. E. James, and M. E. Shirtliff
Antimicrob. Agents Chemother. April 2006 50: 1463-1469;
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Plasmodium falciparum In Vitro Susceptibility to Antimalarial Drugs in Casamance (Southwestern Senegal) during the First 5 Years of Routine Use of Artesunate-Amodiaquine
P. Agnamey, P. Brasseur, P. Eldin de Pecoulas, Michel Vaillant, and P. Olliaro
Antimicrob. Agents Chemother. April 2006 50: 1531-1534;
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Antimalarial Activity of a Synthetic Endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum Isolates from Gabon
Andrea Kreidenweiss, Benjamin Mordmüller, Sanjeev Krishna, and Peter G. Kremsner
Antimicrob. Agents Chemother. April 2006 50: 1535-1537;
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In Vitro Activity of Tigecycline against Burkholderia pseudomallei and Burkholderia thailandensis
Visanu Thamlikitkul and Suwanna Trakulsomboon
Antimicrob. Agents Chemother. April 2006 50: 1555-1557;
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Immunotherapy with Tacrolimus (FK506) Does Not Select for Resistance to Calcineurin Inhibitors in Candida albicans Isolates from Liver Transplant Patients
Jennifer L. Reedy, Shahid Husain, Michael Ison, Timothy L. Pruett, Nina Singh, and Joseph Heitman
Antimicrob. Agents Chemother. April 2006 50: 1573-1577;
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Biologic Response Modifiers:

Human ß-Defensin 2 Induces a Vigorous Cytokine Response in Peripheral Blood Mononuclear Cells
Michele Boniotto, William J. Jordan, Joyce Eskdale, Alessandro Tossi, Nikolinka Antcheva, Sergio Crovella, Nancy D. Connell, and Grant Gallagher
Antimicrob. Agents Chemother. April 2006 50: 1433-1441;
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Letters:

First Report of Extended-Spectrum-ß-Lactamase-Producing Salmonella enterica Isolates in Ireland
Dearbhaile Morris, Mary Whelan, Geraldine Corbett-Feeney, Martin Cormican, Peter Hawkey, Xu Li, and Geraldine Doran
Antimicrob. Agents Chemother. April 2006 50: 1608-1609;
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First Isolation of bla_IMI-2 in an Enterobacter cloacae Clinical Isolate from China
Yun-Song Yu, Xiao-Xing Du, Zhi-Hui Zhou, Ya-Gang Chen, and Lan-Juan Li
Antimicrob. Agents Chemother. April 2006 50: 1610-1611;
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Class 1 Integrons in Salmonella Strains Causing Traveler's Diarrhea
Roberto Cabrera, Francesc Marco, Jordi Vila, Joaquím Ruiz, and Joaquím Gascón
Antimicrob. Agents Chemother. April 2006 50: 1612-1613;
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