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Mechanisms of Resistance:

Dong H. Kwon and Chung-Dar Lu

Polyamines Induce Resistance to Cationic Peptide, Aminoglycoside, and Quinolone Antibiotics in Pseudomonas aeruginosa PAO1
Antimicrob. Agents Chemother. 2006 50: 1615-1622. [Abstract] [Full Text] [PDF]  

John Quale, Simona Bratu, Jyoti Gupta, and David Landman

Interplay of Efflux System, ampC, and oprD Expression in Carbapenem Resistance of Pseudomonas aeruginosa Clinical Isolates
Antimicrob. Agents Chemother. 2006 50: 1633-1641. [Abstract] [Full Text] [PDF]  

Thierry Naas, Daniel Aubert, Thierry Lambert, and Patrice Nordmann

Complex Genetic Structures with Repeated Elements, a sul-Type Class 1 Integron, and the bla_VEB Extended-Spectrum ß-Lactamase Gene
Antimicrob. Agents Chemother. 2006 50: 1745-1752. [Abstract] [Full Text] [PDF]  

Carlos Juan, Bartolomé Moyá, José L. Pérez, and Antonio Oliver

Stepwise Upregulation of the Pseudomonas aeruginosa Chromosomal Cephalosporinase Conferring High-Level ß-Lactam Resistance Involves Three AmpD Homologues
Antimicrob. Agents Chemother. 2006 50: 1780-1787. [Abstract] [Full Text] [PDF]  

M. Rantala, M. Haanperä-Heikkinen, M. Lindgren, H. Seppälä, P. Huovinen, J. Jalava, and the Finnish Study Group for Antimicrobial Resistance

Streptococcus pneumoniae Isolates Resistant to Telithromycin
Antimicrob. Agents Chemother. 2006 50: 1855-1858. [Abstract] [Full Text] [PDF]  

Jing-Jou Yan, Po-Ren Hsueh, Jang-Jih Lu, Feng-Yee Chang, Jainn-Ming Shyr, Jen-Hsien Wan, Yung-Ching Liu, Yin-Ching Chuang, Yi-Chueh Yang, Shih-Ming Tsao, Hsiu-Hung Wu, Li-Shin Wang, Tsuey-Pin Lin, Hsiu-Mei Wu, Hung-Mo Chen, and Jiunn-Jong Wu

Extended-Spectrum ß-Lactamases and Plasmid-Mediated AmpC Enzymes among Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from Seven Medical Centers in Taiwan
Antimicrob. Agents Chemother. 2006 50: 1861-1864. [Abstract] [Full Text] [PDF]  

Dongeun Yong, Yeoung Seon Choi, Kyoung Ho Roh, Chang Ki Kim, Youn Hee Park, Jong Hwa Yum, Kyungwon Lee, and Yunsop Chong

Increasing Prevalence and Diversity of Metallo-ß-Lactamases in Pseudomonas spp., Acinetobacter spp., and Enterobacteriaceae from Korea
Antimicrob. Agents Chemother. 2006 50: 1884-1886. [Abstract] [Full Text] [PDF]  

Christian Dokomajilar, Samuel L. Nsobya, Bryan Greenhouse, Philip J. Rosenthal, and Grant Dorsey

Selection of Plasmodium falciparum pfmdr1 Alleles following Therapy with Artemether-Lumefantrine in an Area of Uganda where Malaria Is Highly Endemic
Antimicrob. Agents Chemother. 2006 50: 1893-1895. [Abstract] [Full Text] [PDF]  

P. Littauer, D. A. Caugant, M. Sangvik, E. A. Høiby, A. Sundsfjord, G. S. Simonsen, and the Norwegian Macrolide Study Group

Macrolide-Resistant Streptococcus pyogenes in Norway: Population Structure and Resistance Determinants
Antimicrob. Agents Chemother. 2006 50: 1896-1899. [Abstract] [Full Text] [PDF]  

Claudia Plinke, Sabine Rüsch-Gerdes, and Stefan Niemann

Significance of Mutations in embB Codon 306 for Prediction of Ethambutol Resistance in Clinical Mycobacterium tuberculosis Isolates
Antimicrob. Agents Chemother. 2006 50: 1900-1902. [Abstract] [Full Text] [PDF]  

Alfonso J. C. Soler Bistué, Fernando A. Martín, Alejandro Petroni, Diego Faccone, Marcelo Galas, Marcelo E. Tolmasky, and Angeles Zorreguieta

Vibrio cholerae InV117, a Class 1 Integron Harboring aac(6')-Ib and bla_CTX-M-2, Is Linked to Transposition Genes
Antimicrob. Agents Chemother. 2006 50: 1903-1907. [Abstract] [Full Text] [PDF]  

Susceptibility:

Dong H. Kwon and Chung-Dar Lu

Polyamines Increase Antibiotic Susceptibility in Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 2006 50: 1623-1627. [Abstract] [Full Text] [PDF]  

Chong-Ren Yang, Ying Zhang, Melissa R. Jacob, Shabana I. Khan, Ying-Jun Zhang, and Xing-Cong Li

Antifungal Activity of C-27 Steroidal Saponins
Antimicrob. Agents Chemother. 2006 50: 1710-1714. [Abstract] [Full Text] [PDF]  

Glenn A. Pankuch, Gengrong Lin, Dianne B. Hoellman, Caryn E. Good, Michael R. Jacobs, and Peter C. Appelbaum

Activity of Retapamulin against Streptococcus pyogenes and Staphylococcus aureus Evaluated by Agar Dilution, Microdilution, E-Test, and Disk Diffusion Methodologies
Antimicrob. Agents Chemother. 2006 50: 1727-1730. [Abstract] [Full Text] [PDF]  

Scott E. Gygax, Jessica A. Schuyler, Lauren E. Kimmel, Jason P. Trama, Eli Mordechai, and Martin E. Adelson

Erythromycin and Clindamycin Resistance in Group B Streptococcal Clinical Isolates
Antimicrob. Agents Chemother. 2006 50: 1875-1877. [Abstract] [Full Text] [PDF] [Supplemental material]  

D. Molitoris, M.-L. Väisänen, M. Bolaños, and S. M. Finegold

In Vitro Activities of DX-619 and Four Comparator Agents against 376 Anaerobic Bacterial Isolates
Antimicrob. Agents Chemother. 2006 50: 1887-1889. [Abstract] [Full Text] [PDF]  

Olle Aspevall, Annika Lundberg, Lars G. Burman, Thomas Åkerlund, and Bo Svenungsson

Antimicrobial Susceptibility Pattern of Clostridium difficile and Its Relation to PCR Ribotypes in a Swedish University Hospital
Antimicrob. Agents Chemother. 2006 50: 1890-1892. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

David C. Griffith, Erik Corcoran, Denene Lofland, Angela Lee, Deidre Cho, Olga Lomovskaya, and Michael N. Dudley

Pharmacodynamics of Levofloxacin against Pseudomonas aeruginosa with Reduced Susceptibility Due to Different Efflux Pumps: Do Elevated MICs Always Predict Reduced In Vivo Efficacy?
Antimicrob. Agents Chemother. 2006 50: 1628-1632. [Abstract] [Full Text] [PDF]  

Lisa H. Xie, Qigui Li, Ai J. Lin, Kirsten Smith, Jing Zhang, and Donald S. Skillman

New Potential Antimalarial Agents: Therapeutic-Index Evaluation of Pyrroloquinazolinediamine and Its Prodrugs in a Rat Model of Severe Malaria
Antimicrob. Agents Chemother. 2006 50: 1649-1655. [Abstract] [Full Text] [PDF]  

Oscar Cirioni, Andrea Giacometti, Roberto Ghiselli, Cristina Bergnach, Fiorenza Orlando, Carmela Silvestri, Federico Mocchegiani, Alberto Licci, Barbara Skerlavaj, Marco Rocchi, Vittorio Saba, Margherita Zanetti, and Giorgio Scalise

LL-37 Protects Rats against Lethal Sepsis Caused by Gram-Negative Bacteria
Antimicrob. Agents Chemother. 2006 50: 1672-1679. [Abstract] [Full Text] [PDF]  

Alida Coppi, Melissa Cabinian, David Mirelman, and Photini Sinnis

Antimalarial Activity of Allicin, a Biologically Active Compound from Garlic Cloves
Antimicrob. Agents Chemother. 2006 50: 1731-1737. [Abstract] [Full Text] [PDF]  

Ray Hachem, Paul Bahna, Hend Hanna, L. Clifton Stephens, and Issam Raad

EDTA as an Adjunct Antifungal Agent for Invasive Pulmonary Aspergillosis in a Rodent Model
Antimicrob. Agents Chemother. 2006 50: 1823-1827. [Abstract] [Full Text] [PDF]  

Katie O'Riordan, David S. Sharlin, Jerome Gross, Sung Chang, Divya Errabelli, Oleg E. Akilov, Sachiko Kosaka, Gerard J. Nau, and Tayyaba Hasan

Photoinactivation of Mycobacteria In Vitro and in a New Murine Model of Localized Mycobacterium bovis BCG-Induced Granulomatous Infection
Antimicrob. Agents Chemother. 2006 50: 1828-1834. [Abstract] [Full Text] [PDF]  

Elisabeth J. Ruijgrok, Marcel H. A. M. Fens, Irma A. J. M. Bakker-Woudenberg, Els W. M. van Etten, and Arnold G. Vulto

Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis
Antimicrob. Agents Chemother. 2006 50: 1852-1854. [Abstract] [Full Text] [PDF]  

Robert J. Sherertz, Michael S. Boger, Casey A. Collins, Lori Mason, and Issam I. Raad

Comparative In Vitro Efficacies of Various Catheter Lock Solutions
Antimicrob. Agents Chemother. 2006 50: 1865-1868. [Abstract] [Full Text] [PDF]  

Antiviral Agents:

Seng Gee Lim, Zahary Krastev, Tay Meng Ng, Grigor Mechkov, Iskren Andreev Kotzev, Sing Chan, Elsa Mondou, Andrea Snow, Jeff Sorbel, Franck Rousseau for the FTCB-204 Study Group

Randomized, Double-Blind Study of Emtricitabine (FTC) plus Clevudine versus FTC Alone in Treatment of Chronic Hepatitis B
Antimicrob. Agents Chemother. 2006 50: 1642-1648. [Abstract] [Full Text] [PDF]  

Xiao-Jian Zhou, Thomas C. Marbury, Harry W. Alcorn, William B. Smith, Gloria Dubuc Patrick, George C. Chao, and Nathaniel A. Brown

Pharmacokinetics of Telbivudine in Subjects with Various Degrees of Hepatic Impairment
Antimicrob. Agents Chemother. 2006 50: 1721-1726. [Abstract] [Full Text] [PDF]  

M. C. Georges-Courbot, H. Contamin, C. Faure, P. Loth, S. Baize, P. Leyssen, J. Neyts, and V. Deubel

Poly(I)-Poly(C₁₂U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection
Antimicrob. Agents Chemother. 2006 50: 1768-1772. [Abstract] [Full Text] [PDF]  

Kai Lin, Robert B. Perni, Ann D. Kwong, and Chao Lin

VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells
Antimicrob. Agents Chemother. 2006 50: 1813-1822. [Abstract] [Full Text] [PDF]  

Aeron C. Hurt, Pina Iannello, Kim Jachno, Naomi Komadina, Alan W. Hampson, Ian G. Barr, and Jennifer L. McKimm-Breschkin

Neuraminidase Inhibitor-Resistant and -Sensitive Influenza B Viruses Isolated from an Untreated Human Patient
Antimicrob. Agents Chemother. 2006 50: 1872-1874. [Abstract] [Full Text] [PDF]  

Mechanisms of Action:

Wen Wang, Richard White, and Zhengyu Yuan

Proteomic Study of Peptide Deformylase Inhibition in Streptococcus pneumoniae and Staphylococcus aureus
Antimicrob. Agents Chemother. 2006 50: 1656-1663. [Abstract] [Full Text] [PDF]  

Rafal Koziel, Krzysztof Zablocki, and Jerzy Duszynski

Calcium Signals Are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA Content in Jurkat Cells
Antimicrob. Agents Chemother. 2006 50: 1664-1671. [Abstract] [Full Text] [PDF]  

Yusuf Nalca, Lothar Jänsch, Florian Bredenbruch, Robert Geffers, Jan Buer, and Susanne Häussler

Quorum-Sensing Antagonistic Activities of Azithromycin in Pseudomonas aeruginosa PAO1: a Global Approach
Antimicrob. Agents Chemother. 2006 50: 1680-1688. [Abstract] [Full Text] [PDF]  

Magally Romero-Tabarez, Rolf Jansen, Marita Sylla, Heinrich Lünsdorf, Susanne Häußler, Dwi A. Santosa, Kenneth N. Timmis, and Gabriella Molinari

7-O-Malonyl Macrolactin A, a New Macrolactin Antibiotic from Bacillus subtilis Active against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, and a Small-Colony Variant of Burkholderia cepacia
Antimicrob. Agents Chemother. 2006 50: 1701-1709. [Abstract] [Full Text] [PDF]  

Masaharu Shinkai, Jun Tamaoki, Hideo Kobayashi, Soichiro Kanoh, Kazuo Motoyoshi, Tim Kute, and Bruce K. Rubin

Clarithromycin Delays Progression of Bronchial Epithelial Cells from G₁ Phase to S Phase and Delays Cell Growth via Extracellular Signal-Regulated Protein Kinase Suppression
Antimicrob. Agents Chemother. 2006 50: 1738-1744. [Abstract] [Full Text] [PDF]  

Naomi E. Kramer, Sacha A. F. T. van Hijum, Jan Knol, Jan Kok, and Oscar P. Kuipers

Transcriptome Analysis Reveals Mechanisms by Which Lactococcus lactis Acquires Nisin Resistance
Antimicrob. Agents Chemother. 2006 50: 1753-1761. [Abstract] [Full Text] [PDF]  

Jayati Mookerjee Basu, Ananda Mookerjee, Prosenjit Sen, Suniti Bhaumik, Pradip Sen, Subha Banerjee, Ksudiram Naskar, Soumitra K. Choudhuri, Bhaskar Saha, Sanghamitra Raha, and Syamal Roy

Sodium Antimony Gluconate Induces Generation of Reactive Oxygen Species and Nitric Oxide via Phosphoinositide 3-Kinase and Mitogen-Activated Protein Kinase Activation in Leishmania donovani-Infected Macrophages
Antimicrob. Agents Chemother. 2006 50: 1788-1797. [Abstract] [Full Text] [PDF]  

Willias Masocha, Martin E. Rottenberg, and Krister Kristensson

Minocycline Impedes African Trypanosome Invasion of the Brain in a Murine Model
Antimicrob. Agents Chemother. 2006 50: 1798-1804. [Abstract] [Full Text] [PDF]  

Euan Burton, Purushottam V. Gawande, Nandadeva Yakandawala, Karen LoVetri, George G. Zhanel, Tony Romeo, Albert D. Friesen, and Srinivasa Madhyastha

Antibiofilm Activity of GlmU Enzyme Inhibitors against Catheter-Associated Uropathogens
Antimicrob. Agents Chemother. 2006 50: 1835-1840. [Abstract] [Full Text] [PDF]  

Giancarlo A. Biagini, Parnpen Viriyavejakul, Paul M. O'Neill, Patrick G. Bray, and Stephen A. Ward

Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria
Antimicrob. Agents Chemother. 2006 50: 1841-1851. [Abstract] [Full Text] [PDF]  

Pharmacology:

Jean-Michel Michot, Marie F. Heremans, Nancy E. Caceres, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, and Françoise Van Bambeke

Cellular Accumulation and Activity of Quinolones in Ciprofloxacin-Resistant J774 Macrophages
Antimicrob. Agents Chemother. 2006 50: 1689-1695. [Abstract] [Full Text] [PDF]  

Seulki Lee, Sang Kyoon Kim, Dong Yun Lee, Su Young Chae, and Youngro Byun

Pharmacokinetics of a New, Orally Available Ceftriaxone Formulation in Physical Complexation with a Cationic Analogue of Bile Acid in Rats
Antimicrob. Agents Chemother. 2006 50: 1869-1871. [Abstract] [Full Text] [PDF]  

Angela Sansone-Parsons, Gopal Krishna, Angela Calzetta, David Wexler, Bhavna Kantesaria, Mitchell A. Rosenberg, and Marc A. Saltzman

Effect of a Nutritional Supplement on Posaconazole Pharmacokinetics following Oral Administration to Healthy Volunteers
Antimicrob. Agents Chemother. 2006 50: 1881-1883. [Abstract] [Full Text] [PDF]  

Clinical Therapeutics:

D. L. Patton, Y. T. Cosgrove Sweeney, T. D. McCarthy, and S. L. Hillier

Preclinical Safety and Efficacy Assessments of Dendrimer-Based (SPL7013) Microbicide Gel Formulations in a Nonhuman Primate Model
Antimicrob. Agents Chemother. 2006 50: 1696-1700. [Abstract] [Full Text] [PDF]  

Deverick J. Anderson, John J. Engemann, Lizzie J. Harrell, Yehuda Carmeli, L. Barth Reller, and Keith S. Kaye

Predictors of Mortality in Patients with Bloodstream Infection Due to Ceftazidime-Resistant Klebsiella pneumoniae
Antimicrob. Agents Chemother. 2006 50: 1715-1720. [Abstract] [Full Text] [PDF]  

Jose-Luis Alvarez-Sala, Peter Kardos, Jesús Martínez-Beltrán, Pilar Coronel, Lorenzo Aguilar, and the Cefditoren AECB Working Group

Clinical and Bacteriological Efficacy in Treatment of Acute Exacerbations of Chronic Bronchitis with Cefditoren-Pivoxil versus Cefuroxime-Axetil
Antimicrob. Agents Chemother. 2006 50: 1762-1767. [Abstract] [Full Text] [PDF]  

Beda Joos, Alexandra Trkola, Herbert Kuster, Leonardo Aceto, Marek Fischer, Gabriela Stiegler, Christine Armbruster, Brigitta Vcelar, Hermann Katinger, and Huldrych F. Günthard

Long-Term Multiple-Dose Pharmacokinetics of Human Monoclonal Antibodies (MAbs) against Human Immunodeficiency Virus Type 1 Envelope gp120 (MAb 2G12) and gp41 (MAbs 4E10 and 2F5)
Antimicrob. Agents Chemother. 2006 50: 1773-1779. [Abstract] [Full Text] [PDF]  

Dalavaikodihalli Nanjaiah Nandakumar, Viswanathan Arun Nagaraj, Palakkod Govindan Vathsala, Pundi Rangarajan, and Govindarajan Padmanaban

Curcumin-Artemisinin Combination Therapy for Malaria
Antimicrob. Agents Chemother. 2006 50: 1859-1860. [Abstract] [Full Text] [PDF]  

Blair Capitano, Brian A. Potoski, Shahid Husain, Shimin Zhang, David L. Paterson, Sean M. Studer, Kenneth R. McCurry, and Raman Venkataramanan

Intrapulmonary Penetration of Voriconazole in Patients Receiving an Oral Prophylactic Regimen
Antimicrob. Agents Chemother. 2006 50: 1878-1880. [Abstract] [Full Text] [PDF]  

Biologic Response Modifiers:

Valthor Asgrimsson, Thorarinn Gudjonsson, Gudmundur Hrafn Gudmundsson, and Olafur Baldursson

Novel Effects of Azithromycin on Tight Junction Proteins in Human Airway Epithelia
Antimicrob. Agents Chemother. 2006 50: 1805-1812. [Abstract] [Full Text] [PDF]  

Letters:

Steve Mullin, David M. Rothstein, and Christopher K. Murphy

Activity of Novel Benzoxazinorifamycins against Rifamycin-Resistant Streptococcus pyogenes
Antimicrob. Agents Chemother. 2006 50: 1908-1909. [Full Text] [PDF]  

Andre C. Kalil, Susan Puumala, Julie Stoner, John Weigelt, Kamal Itani, Dennis Stevens, and Charles Knirsch

Is Linezolid Superior to Vancomycin for Complicated Skin and Soft Tissue Infections Due to Methicillin-Resistant Staphylococcus aureus?
Antimicrob. Agents Chemother. 2006 50: 1910-1911. [Full Text] [PDF]  

Recent Approvals:

New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 2005 and New Indications for Previously Approved Agents
Antimicrob. Agents Chemother. 2006 50: 1912. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.