AAC -- Table of Contents (July 1 2006, 50 [7])

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Contents: July 2006, Volume 50, Issue 7

       Clinical Therapeutics

       Susceptibility

       Pharmacology

       Mechanisms of Resistance

       Antiviral Agents

       Mechanisms of Action

       Experimental Therapeutics

       Errata

Other Issues

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Clinical Therapeutics:

Population Pharmacokinetic Assessment of a New Regimen of Mefloquine Used in Combination Treatment of Uncomplicated Falciparum Malaria
Elizabeth A. Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Robert Hutagalung, Rae Hae, Pratap Singhasivanon, Nicholas J. White, and François Nosten
Antimicrob. Agents Chemother. July 2006 50: 2281-2285;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Probabilistic Modeling within a Physiologically Based Pharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine
Jennifer Buur, Ronald Baynes, Geof Smith, and Jim Riviere
Antimicrob. Agents Chemother. July 2006 50: 2344-2351;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Unbound Linezolid in Plasma and Tissue Interstitium of Critically Ill Patients after Multiple Dosing Using Microdialysis
Cornelia Buerger, Nele Plock, Pejman Dehghanyar, Christian Joukhadar, and Charlotte Kloft
Antimicrob. Agents Chemother. July 2006 50: 2455-2463;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Antimicrobial Activity and Spectrum of Cefovecin, a New Extended- Spectrum Cephalosporin, against Pathogens Collected from Dogs and Cats in Europe and North America
M. R. Stegemann, C. A. Passmore, J. Sherington, C. J. Lindeman, G. Papp, D. J. Weigel, and T. L. Skogerboe
Antimicrob. Agents Chemother. July 2006 50: 2286-2292;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of LBM415 Compared to Those of 11 Other Agents against Haemophilus Species
Tatiana Bogdanovich, Kathy A. Smith, Catherine Clark, Glenn A. Pankuch, Gengrong Lin, Pamela McGhee, Bonifacio Dewasse, and Peter C. Appelbaum
Antimicrob. Agents Chemother. July 2006 50: 2323-2329;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Daptomycin Bactericidal Activity and Correlation between Disk and Broth Microdilution Method Results in Testing of Staphylococcus aureus Strains with Decreased Susceptibility to Vancomycin
Helio S. Sader, Thomas R. Fritsche, and Ronald N. Jones
Antimicrob. Agents Chemother. July 2006 50: 2330-2336;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Results Obtained with Various Antifungal Susceptibility Testing Methods Do Not Predict Early Clinical Outcome in Patients with Cryptococcosis
E. Dannaoui, M. Abdul, M. Arpin, A. Michel-Nguyen, M. A. Piens, A. Favel, O. Lortholary, F. Dromer, and the French Cryptococcosis Study Group
Antimicrob. Agents Chemother. July 2006 50: 2464-2470;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of a Candida krusei Isolate with Reduced Susceptibility to Caspofungin during Therapy
Morgan Hakki, Janet F. Staab, and Kieren A. Marr
Antimicrob. Agents Chemother. July 2006 50: 2522-2524;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Ceftobiprole and Other ß-Lactams against Streptococcus pneumoniae Clinical Isolates from the United States with Defined Substitutions in Penicillin-Binding Proteins PBP 1a, PBP 2b, and PBP 2x
Todd A. Davies, Wenchi Shang, and Karen Bush
Antimicrob. Agents Chemother. July 2006 50: 2530-2532;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Risk Factors for Isolation of Strains Susceptible Only to Polymyxin among Patients with Pseudomonas aeruginosa Bacteremia
Matthew E. Falagas, Patra K. Koletsi, Petros Kopterides, and Argyris Michalopoulos
Antimicrob. Agents Chemother. July 2006 50: 2541-2543;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterizing the Effects of Caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments
Cornelius J. Clancy, Hong Huang, Shaoji Cheng, Hartmut Derendorf, and M. Hong Nguyen
Antimicrob. Agents Chemother. July 2006 50: 2569-2572;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Retapamulin (SB-275833), a Novel Pleuromutilin, against Selected Resistant Gram-Positive Cocci
Ronald N. Jones, Thomas R. Fritsche, Helio S. Sader, and James E. Ross
Antimicrob. Agents Chemother. July 2006 50: 2583-2586;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Absence of Cochleotoxicity Measured by Standard and High-Frequency Pure Tone Audiometry in a Trial of Once- versus Three-Times-Daily Tobramycin in Cystic Fibrosis Patients
Michael Mulheran, Pauline Hyman-Taylor, Kelvin H.-V. Tan, Sarah Lewis, David Stableforth, Alan Knox, and Alan Smyth
Antimicrob. Agents Chemother. July 2006 50: 2293-2299;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective Determination of Plasma Imipenem Concentrations in Critically Ill Children
Eric Giannoni, Philippe Moreillon, Jacques Cotting, Adrien Moessinger, Jacques Bille, Laurent Décosterd, Giorgio Zanetti, Paul Majcherczyk, and Denis Bugnon
Antimicrob. Agents Chemother. July 2006 50: 2563-2568;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

Multiple cis-Acting Sequences Mediate Upregulation of the MDR1 Efflux Pump in a Fluconazole-Resistant Clinical Candida albicans Isolate
Davina Hiller, Stephanie Stahl, and Joachim Morschhäuser
Antimicrob. Agents Chemother. July 2006 50: 2300-2308;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

CMT-Type ß-Lactamase TEM-125, an Emerging Problem for Extended-Spectrum ß-Lactamase Detection
Frédéric Robin, Julien Delmas, Maryse Archambaud, Cédric Schweitzer, Catherine Chanal, and Richard Bonnet
Antimicrob. Agents Chemother. July 2006 50: 2403-2408;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Drug Resistance in Clonally Related Clinical Isolates of Vibrio fluvialis Isolated in Kolkata, India
Vijaya Bharathi Srinivasan, Rupinder Kaur Virk, Amita Kaundal, Rupa Chakraborty, Basabjit Datta, T. Ramamurthy, Asish K. Mukhopadhyay, and Amit Ghosh
Antimicrob. Agents Chemother. July 2006 50: 2428-2432;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clonal Dissemination of a CTX-M-15 ß-Lactamase-Producing Escherichia coli Strain in the Paris Area, Tunis, and Bangui
M. Lavollay, K. Mamlouk, T. Frank, A. Akpabie, B. Burghoffer, S. Ben Redjeb, R. Bercion, V. Gautier, and G. Arlet
Antimicrob. Agents Chemother. July 2006 50: 2433-2438;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Low-Level Resistance of Staphylococcus aureus to Thrombin-Induced Platelet Microbicidal Protein 1 In Vitro Associated with qacA Gene Carriage Is Independent of Multidrug Efflux Pump Activity
A. S. Bayer, L. I. Kupferwasser, M. H. Brown, R. A. Skurray, S. Grkovic, T. Jones, K. Mukhopadhay, and M. R. Yeaman
Antimicrob. Agents Chemother. July 2006 50: 2448-2454;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Evolution of ß-Lactam-Resistant Haemophilus influenzae: 9-Year Surveillance of Penicillin-Binding Protein 3 Mutations in Isolates from Japan
Yumiko Sanbongi, Takahisa Suzuki, Yumi Osaki, Nami Senju, Takashi Ida, and Kimiko Ubukata
Antimicrob. Agents Chemother. July 2006 50: 2487-2492;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Cluster of Plasmid-Located Class 1 Integrons in Vibrio cholerae O1 and a dfrA15 Cassette-Containing Integron in Vibrio parahaemolyticus Isolated in Angola
Daniela Ceccarelli, Anna Maria Salvia, Joana Sami, Piero Cappuccinelli, and Mauro Maria Colombo
Antimicrob. Agents Chemother. July 2006 50: 2493-2499;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics
Katherine S. Long, Jacob Poehlsgaard, Corinna Kehrenberg, Stefan Schwarz, and Birte Vester
Antimicrob. Agents Chemother. July 2006 50: 2500-2505;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reverse Engineering Antibiotic Sensitivity in a Multidrug-Resistant Pseudomonas aeruginosa Isolate
Julie M. Struble and Ryan T. Gill
Antimicrob. Agents Chemother. July 2006 50: 2506-2515;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Crystal Structure of the Mycobacterium fortuitum Class A ß-Lactamase: Structural Basis for Broad Substrate Specificity
Eric Sauvage, Eveline Fonzé, Birgit Quinting, Moreno Galleni, Jean-Marie Frère, and Paulette Charlier
Antimicrob. Agents Chemother. July 2006 50: 2516-2521;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus
E. M. F. Rocha, R. E. Gardiner, S. Park, N. M. Martinez-Rossi, and D. S. Perlin
Antimicrob. Agents Chemother. July 2006 50: 2533-2536;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Common Region CR1 for Expression of Antibiotic Resistance Genes
Jose-Manuel Rodriguez-Martinez, Laurent Poirel, Rafael Canton, and Patrice Nordmann
Antimicrob. Agents Chemother. July 2006 50: 2544-2546;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intrinsic Macrolide Resistance of the Mycobacterium tuberculosis Complex Is Inducible
Nadya Andini and Kevin A. Nash
Antimicrob. Agents Chemother. July 2006 50: 2560-2562;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli
Hedi Mammeri, Laurent Poirel, Nicolas Fortineau, and Patrice Nordmann
Antimicrob. Agents Chemother. July 2006 50: 2573-2576;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions between Glycopeptides and ß-Lactams against Isogenic Pairs of Teicoplanin-Susceptible and -Resistant Strains of Staphylococcus haemolyticus
Carla Vignaroli, Francesca Biavasco, and Pietro E. Varaldo
Antimicrob. Agents Chemother. July 2006 50: 2577-2582;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Pharmacokinetics of Telbivudine in Healthy Subjects and Absence of Drug Interaction with Lamivudine or Adefovir Dipivoxil
Xiao-Jian Zhou, Barbara A. Fielman, Deborah M. Lloyd, George C. Chao, and Nathaniel A. Brown
Antimicrob. Agents Chemother. July 2006 50: 2309-2315;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Absorption, Metabolism, and Excretion of [¹⁴C]Viramidine in Humans
Chin-chung Lin, Christine Xu, Nanqun Zhu, and Li-Tain Yeh
Antimicrob. Agents Chemother. July 2006 50: 2368-2373;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use
Arnold S. Monto, Jennifer L. McKimm-Breschkin, Catherine Macken, Alan W. Hampson, Alan Hay, Alexander Klimov, Masato Tashiro, Robert G. Webster, Michelle Aymard, Frederick G. Hayden, and Maria Zambon
Antimicrob. Agents Chemother. July 2006 50: 2395-2402;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enteroviral Meningitis: Natural History and Outcome of Pleconaril Therapy
R. A. Desmond, N. A. Accortt, L. Talley, S. A. Villano, S.-J. Soong, and R. J. Whitley
Antimicrob. Agents Chemother. July 2006 50: 2409-2414;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus
William E. Delaney, IV, Adrian S. Ray, Huiling Yang, Xiaoping Qi, Shelly Xiong, Yuao Zhu, and Michael D. Miller
Antimicrob. Agents Chemother. July 2006 50: 2471-2477;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures
Ilya Lebeau, Graciela Andrei, Fabiana Dal Pozzo, James R. Beadle, Karl Y. Hostetler, Erik De Clercq, Joost van den Oord, and Robert Snoeck
Antimicrob. Agents Chemother. July 2006 50: 2525-2529;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Risk Factors for Selection of the L74I Reverse Transcriptase Mutation in Human Immunodeficiency Virus Type 1-Infected Patients
Marc Wirden, Bénédicte Roquebert, Anne Derache, Anne Simon, Claudine Duvivier, Jade Ghosn, Stephanie Dominguez, Véronique Boutonnet, Zaina Ait-Arkoub, Christine Katlama, Vincent Calvez, and Anne-Genevieve Marcelin
Antimicrob. Agents Chemother. July 2006 50: 2553-2556;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of Maribavir
Sunwen Chou, Laura C. Van Wechel, and Gail I. Marousek
Antimicrob. Agents Chemother. July 2006 50: 2557-2559;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Proteolytic Degradation of Human Antimicrobial Peptide LL-37 by Bacillus anthracis May Contribute to Virulence
Joanne E. Thwaite, Stephen Hibbs, Richard W. Titball, and Timothy P. Atkins
Antimicrob. Agents Chemother. July 2006 50: 2316-2322;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinolones Sensitize Gram-Negative Bacteria to Antimicrobial Peptides
Miguel A. Campos, Pau Morey, and José A. Bengoechea
Antimicrob. Agents Chemother. July 2006 50: 2361-2367;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Accelerated Denaturation of Hemoglobin and the Antimalarial Action of Chloroquine
Coy D. Fitch and Natrice V. Russell
Antimicrob. Agents Chemother. July 2006 50: 2415-2419;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aziridine-2,3-Dicarboxylates, Peptidomimetic Cysteine Protease Inhibitors with Antileishmanial Activity
Alicia Ponte-Sucre, Radim Vicik, Martina Schultheis, Tanja Schirmeister, and Heidrun Moll
Antimicrob. Agents Chemother. July 2006 50: 2439-2447;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

In Vitro Selection and In Vivo Efficacy of Piperazine- and Alkanediamide-Linked Bisbenzamidines against Pneumocystis Pneumonia in Mice
Melanie T. Cushion, Peter D. Walzer, Alan Ashbaugh, Sandra Rebholz, Ronald Brubaker, Jean Jacques Vanden Eynde, Annie Mayence, and Tien L. Huang
Antimicrob. Agents Chemother. July 2006 50: 2337-2343;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Survival of Teicoplanin-Resistant Staphylococcus aureus and Fitness Cost of Teicoplanin Resistance
N. McCallum, H. Karauzum, R. Getzmann, M. Bischoff, P. Majcherczyk, B. Berger-Bächi, and R. Landmann
Antimicrob. Agents Chemother. July 2006 50: 2352-2360;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Antimicrobial Dosing Regimen on Evolution of Drug Resistance In Vivo: Fluconazole and Candida albicans
D. Andes, A. Forrest, A. Lepak, J. Nett, K. Marchillo, and L. Lincoln
Antimicrob. Agents Chemother. July 2006 50: 2374-2383;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Fluconazole Pharmacodynamics and Resistance Development in a Previously Susceptible Candida albicans Population Examined by Microbiologic and Transcriptional Profiling
D. Andes, A. Lepak, J. Nett, L. Lincoln, and K. Marchillo
Antimicrob. Agents Chemother. July 2006 50: 2384-2394;
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

The Antimalarial Artemisinin Synergizes with Antibiotics To Protect against Lethal Live Escherichia coli Challenge by Decreasing Proinflammatory Cytokine Release
Jun Wang, Hong Zhou, Jiang Zheng, Juan Cheng, Wei Liu, Guofu Ding, Liangxi Wang, Ping Luo, Yongling Lu, Hongwei Cao, Shuangjiang Yu, Bin Li, and Lezhi Zhang
Antimicrob. Agents Chemother. July 2006 50: 2420-2427;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction of Antimicrobial Peptide Temporin L with Lipopolysaccharide In Vitro and in Experimental Rat Models of Septic Shock Caused by Gram-Negative Bacteria
Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Fiorenza Orlando, Carmela Silvestri, Argante Bozzi, Antonio Di Giulio, Carla Luzi, Maria Luisa Mangoni, Donatella Barra, Vittorio Saba, Giorgio Scalise, and Andrea C. Rinaldi
Antimicrob. Agents Chemother. July 2006 50: 2478-2486;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of a Selective Decontamination of the Digestive Tract Regimen Including Parenteral Cefepime on Establishment of Intestinal Colonization with Vancomycin-Resistant Enterococcus spp. and Klebsiella pneumoniae in Mice
David L. Paterson, Usha Stiefel, and Curtis J. Donskey
Antimicrob. Agents Chemother. July 2006 50: 2537-2540;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Assessment of Linezolid Combined with Ertapenem: a Highly Synergistic Combination against Methicillin-Resistant Staphylococcus aureus
Cedric Jacqueline, Jocelyne Caillon, Olivier Grossi, Virginie Le Mabecque, Anne-Françoise Miegeville, Denis Bugnon, Eric Batard, and Gilles Potel
Antimicrob. Agents Chemother. July 2006 50: 2547-2549;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Polyphenols Reduce Gastritis Induced by Helicobacter pylori Infection or VacA Toxin Administration in Mice
P. Ruggiero, F. Tombola, G. Rossi, L. Pancotto, L. Lauretti, G. Del Giudice, and M. Zoratti
Antimicrob. Agents Chemother. July 2006 50: 2550-2552;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction between Posaconazole and Caspofungin in Concomitant Treatment of Mice with Systemic Aspergillus Infection
Anthony Cacciapuoti, Judith Halpern, Cara Mendrick, Christine Norris, Reena Patel, and David Loebenberg
Antimicrob. Agents Chemother. July 2006 50: 2587-2590;
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Errata:

Overexpression of the MDR1 Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in Candida albicans
Davina Hiller, Dominique Sanglard, and Joachim Morschhäuser
Antimicrob. Agents Chemother. July 2006 50: 2591
[Full Text] [PDF] [Reprints and Permissions]

Evidence for Multiple-Antibiotic Resistance in Campylobacter jejuni Not Mediated by CmeB or CmeF
Lilian Pumbwe, Luke P. Randall, Martin J. Woodward, and Laura J. V. Piddock
Antimicrob. Agents Chemother. July 2006 50: 2592
[Full Text] [PDF] [Reprints and Permissions]

Assessment of the Paradoxical Effect of Caspofungin in Therapy of Candidiasis
Karl V. Clemons, Marife Espiritu, Rachana Parmar, and David A. Stevens
Antimicrob. Agents Chemother. July 2006 50: 2593
[Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.