Contents: August 2006, Volume 50, Issue 8        Mechanisms of Action        Experimental Therapeutics        Mechanisms of Resistance        Susceptibility        Antiviral Agents        Clinical Therapeutics        Biologic Response Modifiers        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Action:

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New Azasterols against Trypanosoma brucei: Role of 24-Sterol Methyltransferase in Inhibitor Action Ludovic Gros, Victor Manuel Castillo-Acosta, Carmen Jiménez Jiménez, Marco Sealey-Cardona, Sofia Vargas, Antonio Manuel Estévez, Vanessa Yardley, Lauren Rattray, Simon L. Croft, Luis M. Ruiz-Perez, Julio A. Urbina, Ian H. Gilbert, and Dolores González Pacanowska Antimicrob. Agents Chemother. August 2006 50: 2595-2601; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determination of the Antibacterial and Lipopolysaccharide-Neutralizing Regions of Guinea Pig Neutrophil Cathelicidin Peptide CAP11 Daiju Okuda, Shin Yomogida, Hiroshi Tamura, and Isao Nagaoka Antimicrob. Agents Chemother. August 2006 50: 2602-2607; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Naturally Processed Dermcidin-Derived Peptides Do Not Permeabilize Bacterial Membranes and Kill Microorganisms Irrespective of Their Charge H. Steffen, S. Rieg, I. Wiedemann, H. Kalbacher, M. Deeg, H.-G. Sahl, A. Peschel, F. Götz, C. Garbe, and B. Schittek Antimicrob. Agents Chemother. August 2006 50: 2608-2620; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Pharmacodynamics of Gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa Vincent H. Tam, Samer Kabbara, Giao Vo, Amy N. Schilling, and Elizabeth A. Coyle Antimicrob. Agents Chemother. August 2006 50: 2626-2631; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Cisplatin Inhibition of Anthrax Lethal Toxin Mahtab Moayeri, Jason F. Wiggins, Robin E. Lindeman, and Stephen H. Leppla Antimicrob. Agents Chemother. August 2006 50: 2658-2665; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Physicochemical Properties That Enhance Discriminative Antibacterial Activity of Short Dermaseptin Derivatives Shahar Rotem, Inna Radzishevsky, and Amram Mor Antimicrob. Agents Chemother. August 2006 50: 2666-2672; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Bacterial Acetyl Coenzyme A Carboxylase Inhibitors with Antibiotic Efficacy In Vivo C. Freiberg, J. Pohlmann, P. G. Nell, R. Endermann, J. Schuhmacher, B. Newton, M. Otteneder, T. Lampe, D. Häbich, and K. Ziegelbauer Antimicrob. Agents Chemother. August 2006 50: 2707-2712; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dual Effects of Plant Steroidal Alkaloids on Saccharomyces cerevisiae Veronika Simons, John P. Morrissey, Maita Latijnhouwers, Michael Csukai, Adam Cleaver, Carol Yarrow, and Anne Osbourn Antimicrob. Agents Chemother. August 2006 50: 2732-2740; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture Lucas D. Tilley, Orion S. Hine, Jill A. Kellogg, Jed N. Hassinger, Dwight D. Weller, Patrick L. Iversen, and Bruce L. Geller Antimicrob. Agents Chemother. August 2006 50: 2789-2796; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synthetic Histidine-Rich Peptides Inhibit Candida Species and Other Fungi In Vitro: Role of Endocytosis and Treatment Implications Jingsong Zhu, Paul W. Luther, Qixin Leng, and A. James Mixson Antimicrob. Agents Chemother. August 2006 50: 2797-2805; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB-Like Genes Deborah E. Geiman, Tirumalai R. Raghunand, Nisheeth Agarwal, and William R. Bishai Antimicrob. Agents Chemother. August 2006 50: 2836-2841; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

AG205, a Novel Agent Directed against FabK of Streptococcus pneumoniae Sho Takahata, Maiko Iida, Yumi Osaki, Jun Saito, Hideo Kitagawa, Tomohiro Ozawa, Takuji Yoshida, and Shigeru Hoshiko Antimicrob. Agents Chemother. August 2006 50: 2869-2871; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Combination Chemotherapy with the Nitroimidazopyran PA-824 and First-Line Drugs in a Murine Model of Tuberculosis Eric Nuermberger, Ian Rosenthal, Sandeep Tyagi, Kathy N. Williams, Deepak Almeida, Charles A. Peloquin, William R. Bishai, and Jacques H. Grosset Antimicrob. Agents Chemother. August 2006 50: 2621-2625; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Development of an Orogastrointestinal Mucosal Model of Candidiasis with Dissemination to Visceral Organs Karl V. Clemons, Gloria M. Gonzalez, Gaurav Singh, Jackie Imai, Marife Espiritu, Rachana Parmar, and David A. Stevens Antimicrob. Agents Chemother. August 2006 50: 2650-2657; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Caspofungin against Candida guilliermondii and Candida parapsilosis Francesco Barchiesi, Elisabetta Spreghini, Serena Tomassetti, Agnese Della Vittoria, Daniela Arzeni, Esther Manso, and Giorgio Scalise Antimicrob. Agents Chemother. August 2006 50: 2719-2727; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cysteine Proteinase Inhibitors in Murine Cysticercosis Salman Baig, Raymond T. Damian, Jorge Morales-Montor, Rupal Thazhath, Amr Ghaleb, Meredith Welch, Jamil Talhouk, and A. Clinton White, Jr. Antimicrob. Agents Chemother. August 2006 50: 2886-2888; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Comparative Analysis of Sequences Flanking tet(W) Resistance Genes in Multiple Species of Gut Bacteria Katarzyna A. Kazimierczak, Harry J. Flint, and Karen P. Scott Antimicrob. Agents Chemother. August 2006 50: 2632-2639; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis Manzour Hernando Hazbón, Michael Brimacombe, Miriam Bobadilla del Valle, Magali Cavatore, Marta Inírida Guerrero, Mandira Varma-Basil, Helen Billman-Jacobe, Caroline Lavender, Janet Fyfe, Lourdes García-García, Clara Inés León, Mridula Bose, Fernando Chaves, Megan Murray, Kathleen D. Eisenach, José Sifuentes-Osornio, M. Donald Cave, Alfredo Ponce de León, and David Alland Antimicrob. Agents Chemother. August 2006 50: 2640-2649; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Genetic and Biochemical Characterization of FUS-1 (OXA-85), a Narrow-Spectrum Class D ß-Lactamase from Fusobacterium nucleatum subsp. polymorphum Christine Voha, Jean-Denis Docquier, Gian Maria Rossolini, and Thierry Fosse Antimicrob. Agents Chemother. August 2006 50: 2673-2679; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CTX-M-Type Extended-Spectrum ß-Lactamases in Italy: Molecular Epidemiology of an Emerging Countrywide Problem Claudia Mugnaioli, Francesco Luzzaro, Filomena De Luca, Gioconda Brigante, Mariagrazia Perilli, Gianfranco Amicosante, Stefania Stefani, Antonio Toniolo, and Gian Maria Rossolini Antimicrob. Agents Chemother. August 2006 50: 2700-2706; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dissemination and Persistence of blaCTX-M-9 Are Linked to Class 1 Integrons Containing CR1 Associated with Defective Transposon Derivatives from Tn402 Located in Early Antibiotic Resistance Plasmids of IncHI2, IncP1-, and IncFI Groups Ângela Novais, Rafael Cantón, Aránzazu Valverde, Elisabete Machado, Juan-Carlos Galán, Luísa Peixe, Alessandra Carattoli, Fernando Baquero, and Teresa M. Coque Antimicrob. Agents Chemother. August 2006 50: 2741-2750; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Crystal Structure and Activity Studies of the Mycobacterium tuberculosis ß-Lactamase Reveal Its Critical Role in Resistance to ß-Lactam Antibiotics Feng Wang, Craig Cassidy, and James C. Sacchettini Antimicrob. Agents Chemother. August 2006 50: 2762-2771; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Subset of Staphylococcus aureus Strains Harboring Staphylococcal Cassette Chromosome mec (SCCmec) Type IV Is Deficient in CcrAB-Mediated SCCmec Excision Michael J. Noto and Gordon L. Archer Antimicrob. Agents Chemother. August 2006 50: 2782-2788; [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Evolution of Drug Resistance in Different Sublineages of Mycobacterium tuberculosis Beijing Genotype Igor Mokrousov, Wei Wei Jiao, Gui Zhi Sun, Jia Wen Liu, Violeta Valcheva, Mo Li, Olga Narvskaya, and A Dong Shen Antimicrob. Agents Chemother. August 2006 50: 2820-2823; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of Penicillin-Binding Protein Homologs to Antibiotic Resistance, Cell Morphology, and Virulence of Listeria monocytogenes EGDe Caitriona M. Guinane, Paul D. Cotter, R. Paul Ross, and Colin Hill Antimicrob. Agents Chemother. August 2006 50: 2824-2828; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Outer Membrane Protein Changes and Efflux Pump Expression Together May Confer Resistance to Ertapenem in Enterobacter cloacae Dóra Szabó, Fernanda Silveira, Andrea M. Hujer, Robert A. Bonomo, Kristine M. Hujer, Jane W. Marsh, Christopher R. Bethel, Yohei Doi, Kathleen Deeley, and David L. Paterson Antimicrob. Agents Chemother. August 2006 50: 2833-2835; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Basis for Natural and Acquired Resistance to the Diarylquinoline R207910 in Mycobacteria Stephanie Petrella, Emmanuelle Cambau, Aurelie Chauffour, Koen Andries, Vincent Jarlier, and Wladimir Sougakoff Antimicrob. Agents Chemother. August 2006 50: 2853-2856; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance Levels and rpoB Gene Mutations among In Vitro-Selected Rifampin-Resistant Mycobacterium tuberculosis Mutants Emma Huitric, Jim Werngren, Pontus Juréen, and Sven Hoffner Antimicrob. Agents Chemother. August 2006 50: 2860-2862; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Integron-Associated Gene Cassette Encoding a Trimethoprim-Resistant DfrB-Type Dihydrofolate Reductase Renee S. Levings, Diane Lightfoot, Liam D. H. Elbourne, Steven P. Djordjevic, and Ruth M. Hall Antimicrob. Agents Chemother. August 2006 50: 2863-2865; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potential Role of Veillonella spp. as a Reservoir of Transferable Tetracycline Resistance in the Oral Cavity D. Ready, J. Pratten, A. P. Roberts, R. Bedi, P. Mullany, and M. Wilson Antimicrob. Agents Chemother. August 2006 50: 2866-2868; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

qnr Prevalence in Ceftazidime-Resistant Enterobacteriaceae Isolates from the United States A. Robicsek, J. Strahilevitz, D. F. Sahm, G. A. Jacoby, and D. C. Hooper Antimicrob. Agents Chemother. August 2006 50: 2872-2874; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Detection of the Plasmid-Mediated Class A Carbapenemase KPC-2 in Clinical Isolates of Klebsiella pneumoniae from South America Maria Virginia Villegas, Karen Lolans, Adriana Correa, Carlos Jose Suarez, Jaime A. Lopez, Marta Vallejo, John P. Quinn the Colombian Nosocomial Resistance Study Group Antimicrob. Agents Chemother. August 2006 50: 2880-2882; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Class II Transposon-Borne Structure Harboring Metallo-ß-Lactamase Gene blaVIM-2 in Pseudomonas putida Laurent Poirel, Ludovic Cabanne, Louis Collet, and Patrice Nordmann Antimicrob. Agents Chemother. August 2006 50: 2889-2891; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Candida albicans and Candida glabrata Clinical Isolates Exhibiting Reduced Echinocandin Susceptibility Santosh Katiyar, Michael Pfaller, and Thomas Edlind Antimicrob. Agents Chemother. August 2006 50: 2892-2894; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Activities of Ceftobiprole, Tigecycline, Daptomycin, and 19 Other Antimicrobials against Methicillin-Resistant Staphylococcus aureus Strains from a National Survey of Belgian Hospitals Olivier Denis, Ariane Deplano, Claire Nonhoff, Marie Hallin, Raf De Ryck, Raymond Vanhoof, Ricardo De Mendonça, and Marc J. Struelens Antimicrob. Agents Chemother. August 2006 50: 2680-2685; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Coresistance in Extended-Spectrum-ß-Lactamase-Producing Enterobacteriaceae and In Vitro Activity of Tigecycline María-Isabel Morosini, María García-Castillo, Teresa M. Coque, Aránzazu Valverde, Ângela Novais, Elena Loza, Fernando Baquero, and Rafael Cantón Antimicrob. Agents Chemother. August 2006 50: 2695-2699; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Daptomycin, Vancomycin, and Penicillin against Clostridium difficile, C. perfringens, Finegoldia magna, and Propionibacterium acnes Kerin L. Tyrrell, Diane M. Citron, Yumi A. Warren, Helen T. Fernandez, C. Vreni Merriam, and Ellie J. C. Goldstein Antimicrob. Agents Chemother. August 2006 50: 2728-2731; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Killing Kinetics of Caspofungin, Micafungin, and Amphotericin B against Candida guilliermondii Emilia Cantón, Javier Pemán, Macrina Sastre, Mónica Romero, and Ana Espinel-Ingroff Antimicrob. Agents Chemother. August 2006 50: 2829-2832; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Moxifloxacin Lethality against Mycobacterium tuberculosis in the Presence and Absence of Chloramphenicol Muhammad Malik and Karl Drlica Antimicrob. Agents Chemother. August 2006 50: 2842-2844; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Flow Cytometric Determination of the Effects of Antibacterial Agents on Mycoplasma agalactiae, Mycoplasma putrefaciens, Mycoplasma capricolum subsp. capricolum, and Mycoplasma mycoides subsp. mycoides Large Colony Type Patricia Assunção, Nuno T. Antunes, Ruben S. Rosales, Carlos Poveda, Jose B. Poveda, and Hazel M. Davey Antimicrob. Agents Chemother. August 2006 50: 2845-2849; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides Yvonne Adams, Craig Freeman, Reinhard Schwartz-Albiez, Vito Ferro, Christopher R. Parish, and Katherine T. Andrews Antimicrob. Agents Chemother. August 2006 50: 2850-2852; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Dalbavancin and 12 Other Agents against 329 Aerobic and Anaerobic Gram-Positive Isolates Recovered from Diabetic Foot Infections Ellie J. C. Goldstein, Diane M. Citron, Yumi A. Warren, Kerin L. Tyrrell, C. Vreni Merriam, and Helen T. Fernandez Antimicrob. Agents Chemother. August 2006 50: 2875-2879; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interactions between Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs Timothy M. E. Davis, Juliana Hamzah, Kenneth F. Ilett, Harin A. Karunajeewa, John C. Reeder, Kevin T. Batty, Sara Hackett, and P. Hugh R. Barrett Antimicrob. Agents Chemother. August 2006 50: 2883-2885; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Model for Intracellular Lamivudine Metabolism in Peripheral Blood Mononuclear Cells Ex Vivo and in Human Immunodeficiency Virus Type 1-Infected Adolescents Zexun Zhou, John H. Rodman, Patricia M. Flynn, Brian L. Robbins, Carrie K. Wilcox, and David Z. D'Argenio Antimicrob. Agents Chemother. August 2006 50: 2686-2694; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dose Separation Does Not Overcome the Pharmacokinetic Interaction between Fosamprenavir and Lopinavir/Ritonavir Amanda H. Corbett, Kristine B. Patterson, Hsiao-Chuan Tien, Leslie A. Kalvass, Joseph J. Eron, Linh T. Ngo, Michael L. Lim, and Angela D. M. Kashuba Antimicrob. Agents Chemother. August 2006 50: 2756-2761; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Nonnucleoside Inhibitors That Select Nucleoside Inhibitor Resistance Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Zhijun Zhang, Michelle Walker, Wen Xu, Jae Hoon Shim, Jean-Luc Girardet, Robert K. Hamatake, and Zhi Hong Antimicrob. Agents Chemother. August 2006 50: 2772-2781; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Real-Time Monitoring System for Human Cytomegalovirus- Infected Cells In Vitro That Uses a Green Fluorescent Protein-PML-Expressing Cell Line T. Ueno, Y. Eizuru, H. Katano, T. Kurata, T. Sata, S. Irie, and K. Ogawa-Goto Antimicrob. Agents Chemother. August 2006 50: 2806-2813; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alkoxyalkyl Esters of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine Are Potent Inhibitors of the Replication of Wild-Type and Drug-Resistant Human Immunodeficiency Virus Type 1 In Vitro Karl Y. Hostetler, Kathy A. Aldern, William B. Wan, Stephanie L. Ciesla, and James R. Beadle Antimicrob. Agents Chemother. August 2006 50: 2857-2859; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Fosmidomycin plus Clindamycin for Treatment of Pediatric Patients Aged 1 to 14 Years with Plasmodium falciparum Malaria Steffen Borrmann, Ingrid Lundgren, Sunny Oyakhirome, Bénido Impouma, Pierre-Blaise Matsiegui, Ayola A. Adegnika, Saadou Issifou, Jürgen F. J. Kun, David Hutchinson, Jochen Wiesner, Hassan Jomaa, and Peter G. Kremsner Antimicrob. Agents Chemother. August 2006 50: 2713-2718; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phase II, Randomized, Double-Blind, Multicenter Study Comparing the Safety and Pharmacokinetics of Tefibazumab to Placebo for Treatment of Staphylococcus aureus Bacteremia J. John Weems, Jr., James P. Steinberg, Scott Filler, John W. Baddley, G. Ralph Corey, Priya Sampathkumar, Lisa Winston, Joseph F. John, Christine J. Kubin, Rohit Talwani, Thomas Moore, Joseph M. Patti, Seth Hetherington, Michele Texter, Eric Wenzel, Violet A. Kelley, and Vance G. Fowler, Jr. Antimicrob. Agents Chemother. August 2006 50: 2751-2755; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Peptide Immunization as an Adjuvant to Chemotherapy in Mice Challenged Intratracheally with Virulent Yeast Cells of Paracoccidioides brasiliensis A. F. Marques, M. B. da Silva, M. A. P. Juliano, L. R. Travassos, and C. P. Taborda Antimicrob. Agents Chemother. August 2006 50: 2814-2819; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Antifungal Prophylaxis Is Effective against Murine Invasive Pulmonary Aspergillosis Gunter Rieg, Brad Spellberg, Julie Schwartz, Yue Fu, John E. Edwards, Jr., Donald C. Sheppard, and Ashraf S. Ibrahim Antimicrob. Agents Chemother. August 2006 50: 2895-2896; [Full Text] [PDF] [Reprints and Permissions]

A New Calcineurin Inhibitor, Pimecrolimus, Inhibits the Growth of Malassezia spp. Takashi Sugita, Mami Tajima, Hisae Tsubuku, Ryoji Tsuboi, and Akemi Nishikawa Antimicrob. Agents Chemother. August 2006 50: 2897-2898; [Full Text] [PDF] [Reprints and Permissions]

Is Stavudine Triphosphate a Natural Metabolite of Zidovudine? Henri Benech, François Becher, Alain Pruvost, Jacques J. Grassi, Margarita Meléndez, and José F. Rodriguez Antimicrob. Agents Chemother. August 2006 50: 2899-2901; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.