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Minireviews:

Federico Perez, Andrea M. Hujer, Kristine M. Hujer, Brooke K. Decker, Philip N. Rather, and Robert A. Bonomo

Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Antimicrob. Agents Chemother. 2007 51: 3471-3484. [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Erica L. Dahl and Philip J. Rosenthal

Multiple Antibiotics Exert Delayed Effects against the Plasmodium falciparum Apicoplast
Antimicrob. Agents Chemother. 2007 51: 3485-3490. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Methee Chayakulkeeree, Thomas H. Rude, Dena L. Toffaletti, and John R. Perfect

Fatty Acid Synthesis Is Essential for Survival of Cryptococcus neoformans and a Potential Fungicidal Target
Antimicrob. Agents Chemother. 2007 51: 3537-3545. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Melissa E. Boyne, Todd J. Sullivan, Christopher W. amEnde, Hao Lu, Veronica Gruppo, Darragh Heaslip, Anita G. Amin, Delphi Chatterjee, Anne Lenaerts, Peter J. Tonge, and Richard A. Slayden

Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity InhA Inhibitors
Antimicrob. Agents Chemother. 2007 51: 3562-3567. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Lauren M. Junker and Jon Clardy

High-Throughput Screens for Small-Molecule Inhibitors of Pseudomonas aeruginosa Biofilm Development
Antimicrob. Agents Chemother. 2007 51: 3582-3590. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Pedro M. Pereira, Sérgio R. Filipe, Alexander Tomasz, and Mariana G. Pinho

Fluorescence Ratio Imaging Microscopy Shows Decreased Access of Vancomycin to Cell Wall Synthetic Sites in Vancomycin-Resistant Staphylococcus aureus
Antimicrob. Agents Chemother. 2007 51: 3627-3633. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nadine Hoffmann, Baoleri Lee, Morten Hentzer, Thomas Bovbjerg Rasmussen, Zhijun Song, Helle Krogh Johansen, Michael Givskov, and Niels Høiby

Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr^–/– Mice
Antimicrob. Agents Chemother. 2007 51: 3677-3687. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Leandro Vetcher, Hugo G. Menzella, Toshiaki Kudo, Takayuki Motoyama, and Leonard Katz

The Antifungal Polyketide Ambruticin Targets the HOG Pathway
Antimicrob. Agents Chemother. 2007 51: 3734-3736. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chiatogu Onyewu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, and Joseph Heitman

Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model
Antimicrob. Agents Chemother. 2007 51: 3743-3746. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Neeraj Chauhan, Michael Kruppa, and Richard Calderone

The Ssk1p Response Regulator and Chk1p Histidine Kinase Mutants of Candida albicans Are Hypersensitive to Fluconazole and Voriconazole
Antimicrob. Agents Chemother. 2007 51: 3747-3751. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christophe Loup, Joël Lelièvre, Françoise Benoit-Vical, and Bernard Meunier

Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine
Antimicrob. Agents Chemother. 2007 51: 3768-3770. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Johan Van Eldere, Robertino M. Mera, Linda A. Miller, James A. Poupard, and Heather Amrine-Madsen

Risk Factors for Development of Multiple-Class Resistance to Streptococcus pneumoniae Strains in Belgium over a 10-Year Period: Antimicrobial Consumption, Population Density, and Geographic Location
Antimicrob. Agents Chemother. 2007 51: 3491-3497. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Naowarat Tanomsing, Mallika Imwong, Sasithon Pukrittayakamee, Kesinee Chotivanich, Sornchai Looareesuwan, Mayfong Mayxay, Christiane Dolecek, Tran Tinh Hien, Virgilio E. do Rosario, Ana Paula Arez, Pascal Michon, Georges Snounou, Nicholas J. White, and Nicholas P. J. Day

Genetic Analysis of the Dihydrofolate Reductase-Thymidylate Synthase Gene from Geographically Diverse Isolates of Plasmodium malariae
Antimicrob. Agents Chemother. 2007 51: 3523-3530. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Didier Hocquet, Philippe Berthelot, Micheline Roussel-Delvallez, Roger Favre, Katy Jeannot, Odile Bajolet, Nicole Marty, Florence Grattard, Patricia Mariani-Kurkdjian, Edouard Bingen, Marie-Odile Husson, Gérard Couetdic, and Patrick Plésiat

Pseudomonas aeruginosa May Accumulate Drug Resistance Mechanisms without Losing Its Ability To Cause Bloodstream Infections
Antimicrob. Agents Chemother. 2007 51: 3531-3536. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. V. Lynch, L. Dixon, M. R. Benoit, E. L. Brodie, M. Keyhan, P. Hu, D. F. Ackerley, G. L. Andersen, and A. Matin

Role of the rapA Gene in Controlling Antibiotic Resistance of Escherichia coli Biofilms
Antimicrob. Agents Chemother. 2007 51: 3650-3658. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Ling-Xiang Zhu, Zhi-Wei Zhang, Dong Liang, Di Jiang, Can Wang, Ning Du, Qiong Zhang, Keith Mitchelson, and Jing Cheng

Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae
Antimicrob. Agents Chemother. 2007 51: 3707-3713. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Costas C. Papagiannitsis, Leonidas S. Tzouvelekis, Eva Tzelepi, and Vivi Miriagou

Plasmid-Encoded ACC-4, an Extended-Spectrum Cephalosporinase Variant from Escherichia coli
Antimicrob. Agents Chemother. 2007 51: 3763-3767. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Leah Tong, Truc K. Phan, Kelly L. Robinson, Darius Babusis, Robert Strab, Siddhartha Bhoopathy, Ismael J. Hidalgo, Gerald R. Rhodes, and Adrian S. Ray

Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro
Antimicrob. Agents Chemother. 2007 51: 3498-3504. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

George R. Painter, Merrick R. Almond, Lawrence C. Trost, Bernhard M. Lampert, Johan Neyts, Erik De Clercq, Brent E. Korba, Kathy A. Aldern, James R. Beadle, and Karl Y. Hostetler

Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections
Antimicrob. Agents Chemother. 2007 51: 3505-3509. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Patricia M. Flynn, John Rodman, Jane C. Lindsey, Brian Robbins, Edmund Capparelli, Katherine M. Knapp, Jose F. Rodriguez, James McNamara, Leslie Serchuck, Barbara Heckman, Jaime Martinez the PACTG P1012 Team

Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents
Antimicrob. Agents Chemother. 2007 51: 3516-3522. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Wade S. Blair, Joan Cao, Lynn Jackson, Judith Jimenez, Qinghai Peng, Hua Wu, Jason Isaacson, Scott L. Butler, Alex Chu, Joanne Graham, Anne-Marie Malfait, Micky Tortorella, and Amy K. Patick

Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing
Antimicrob. Agents Chemother. 2007 51: 3554-3561. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lee F. Peng, Sun Suk Kim, Sirinya Matchacheep, Xiaoguang Lei, Shun Su, Wenyu Lin, Weerawat Runguphan, Won-Hyeok Choe, Naoya Sakamoto, Masanori Ikeda, Nobuyuki Kato, Aaron B. Beeler, John A. Porco, Jr., Stuart L. Schreiber, and Raymond T. Chung

Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen
Antimicrob. Agents Chemother. 2007 51: 3756-3759. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Clinical Therapeutics:

Thomas P. Lodise, Jr., Nimish Patel, Andrea Kwa, Jeffrey Graves, Jon P. Furuno, Eileen Graffunder, Ben Lomaestro, and Jessina C. McGregor

Predictors of 30-Day Mortality among Patients with Pseudomonas aeruginosa Bloodstream Infections: Impact of Delayed Appropriate Antibiotic Selection
Antimicrob. Agents Chemother. 2007 51: 3510-3515. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Scott T. Micek, Katherine E. Kollef, Richard M. Reichley, Nareg Roubinian, and Marin H. Kollef

Health Care-Associated Pneumonia and Community-Acquired Pneumonia: a Single-Center Experience
Antimicrob. Agents Chemother. 2007 51: 3568-3573. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Patrick F. Smith, Abayomi Ogundele, Alan Forrest, John Wilton, Karl Salzwedel, Judy Doto, Graham P. Allaway, and David E. Martin

Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3',3'-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection
Antimicrob. Agents Chemother. 2007 51: 3574-3581. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael W. Ellis, Matthew E. Griffith, David P. Dooley, Joseph C. McLean, James H. Jorgensen, Jan E. Patterson, Kepler A. Davis, Joshua S. Hawley, Jason A. Regules, Robert G. Rivard, Paula J. Gray, Julia M. Ceremuga, Mary A. DeJoseph, and Duane R. Hospenthal

Targeted Intranasal Mupirocin To Prevent Colonization and Infection by Community-Associated Methicillin-Resistant Staphylococcus aureus Strains in Soldiers: a Cluster Randomized Controlled Trial
Antimicrob. Agents Chemother. 2007 51: 3591-3598. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

George H. Talbot, Dirk Thye, Anita Das, and Yigong Ge

Phase 2 Study of Ceftaroline versus Standard Therapy in Treatment of Complicated Skin and Skin Structure Infections
Antimicrob. Agents Chemother. 2007 51: 3612-3616. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Thomas P. Lodise, Jr., Peggy S. McKinnon, Donald P. Levine, and Michael J. Rybak

Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus
Antimicrob. Agents Chemother. 2007 51: 3731-3733. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chemistry; Biosynthesis:

Gaëlle Vassiliadis, Jean Peduzzi, Séverine Zirah, Xavier Thomas, Sylvie Rebuffat, and Delphine Destoumieux-Garzón

Insight into Siderophore-Carrying Peptide Biosynthesis: Enterobactin Is a Precursor for Microcin E492 Posttranslational Modification
Antimicrob. Agents Chemother. 2007 51: 3546-3553. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David A. Ostrov, José A. Hernández Prada, Patrick E. Corsino, Kathryn A. Finton, Nhan Le, and Thomas C. Rowe

Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening
Antimicrob. Agents Chemother. 2007 51: 3688-3698. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Juan L. Rodríguez-Tudela, Benito Almirante, Dolors Rodríguez-Pardo, Fernando Laguna, J. Peter Donnelly, Johan W. Mouton, Albert Pahissa, and Manuel Cuenca-Estrella

Correlation of the MIC and Dose/MIC Ratio of Fluconazole to the Therapeutic Response of Patients with Mucosal Candidiasis and Candidemia
Antimicrob. Agents Chemother. 2007 51: 3599-3604. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Albrecht Serfling, Johannes Wohlrab, and Holger B. Deising

Treatment of a Clinically Relevant Plant-Pathogenic Fungus with an Agricultural Azole Causes Cross-Resistance to Medical Azoles and Potentiates Caspofungin Efficacy
Antimicrob. Agents Chemother. 2007 51: 3672-3676. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Jerome R. Lo-Ten-Foe, Anne Marie G. A. de Smet, Bram M. W. Diederen, Jan A. J. W. Kluytmans, and Peter H. J. van Keulen

Comparative Evaluation of the VITEK 2, Disk Diffusion, Etest, Broth Microdilution, and Agar Dilution Susceptibility Testing Methods for Colistin in Clinical Isolates, Including Heteroresistant Enterobacter cloacae and Acinetobacter baumannii Strains
Antimicrob. Agents Chemother. 2007 51: 3726-3730. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pascale Joseph, Marie-Rose Abdo, Rose-Anne Boigegrain, Jean-Louis Montero, Jean-Yves Winum, and Stephan Köhler

Targeting of the Brucella suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen
Antimicrob. Agents Chemother. 2007 51: 3752-3755. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Lorna E. T. Stearne, Wil H. F. Goessens, Johan W. Mouton, and Inge C. Gyssens

Effect of Dosing and Dosing Frequency on the Efficacy of Ceftizoxime and the Emergence of Ceftizoxime Resistance during the Early Development of Murine Abscesses Caused by Bacteroides fragilis and Enterobacter cloacae Mixed Infection
Antimicrob. Agents Chemother. 2007 51: 3605-3611. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Akira Shimotoyodome, Takashi Koudate, Hisataka Kobayashi, Junji Nakamura, Ichiro Tokimitsu, Tadashi Hase, Takashi Inoue, Takashi Matsukubo, and Yoshinori Takaesu

Reduction of Streptococcus mutans Adherence and Dental Biofilm Formation by Surface Treatment with Phosphorylated Polyethylene Glycol
Antimicrob. Agents Chemother. 2007 51: 3634-3641. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Beate Henrichfreise, Irith Wiegand, Ingeborg Luhmer-Becker, and Bernd Wiedemann

Development of Resistance in Wild-Type and Hypermutable Pseudomonas aeruginosa Strains Exposed to Clinical Pharmacokinetic Profiles of Meropenem and Ceftazidime Simulated In Vitro
Antimicrob. Agents Chemother. 2007 51: 3642-3649. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Wesley C. Van Voorhis, Kasey L. Rivas, Pravin Bendale, Laxman Nallan, Carolyn Hornéy, Lynn K. Barrett, Kevin D. Bauer, Brian P. Smart, Sudha Ankala, Oliver Hucke, Christophe L. M. J. Verlinde, Debopam Chakrabarti, Corey Strickland, Kohei Yokoyama, Frederick S. Buckner, Andrew D. Hamilton, David K. Williams, Louis J. Lombardo, David Floyd, and Michael H. Gelb

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase
Antimicrob. Agents Chemother. 2007 51: 3659-3671. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

M. Torrico, L. Aguilar, N. González, M. J. Giménez, O. Echeverría, F. Cafini, D. Sevillano, L. Alou, P. Coronel, and J. Prieto

Influence of TEM-1 ß-Lactamase on the Pharmacodynamic Activity of Simulated Total versus Free-Drug Serum Concentrations of Cefditoren (400 Milligrams) versus Amoxicillin-Clavulanic Acid (2,000/125 Milligrams) against Haemophilus influenzae Strains Exhibiting an N526K Mutation in the ftsI Gene
Antimicrob. Agents Chemother. 2007 51: 3699-3706. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Baohong Ji, Aurélie Chauffour, Jérôme Robert, Sébastien Lefrançois, and Vincent Jarlier

Orally Administered Combined Regimens for Treatment of Mycobacterium ulcerans Infection in Mice
Antimicrob. Agents Chemother. 2007 51: 3737-3739. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

William W. Hope, Peter A. Warn, Andrew Sharp, Paul Reed, Brian Keevil, Arnold Louie, Thomas J. Walsh, David W. Denning, and George L. Drusano

Optimization of the Dosage of Flucytosine in Combination with Amphotericin B for Disseminated Candidiasis: a Pharmacodynamic Rationale for Reduced Dosing
Antimicrob. Agents Chemother. 2007 51: 3760-3762. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

María José de Jesús Valle, Francisco González López, Alfonso Domínguez-Gil Hurlé, and Amparo Sánchez Navarro

Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung
Antimicrob. Agents Chemother. 2007 51: 3771-3774. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Ping Liu, Grover Foster, Kuan Gandelman, Robert R. LaBadie, Mark J. Allison, Maria J. Gutierrez, and Amarnath Sharma

Steady-State Pharmacokinetic and Safety Profiles of Voriconazole and Ritonavir in Healthy Male Subjects
Antimicrob. Agents Chemother. 2007 51: 3617-3626. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

William W. Hope, Nita L. Seibel, Cindy L. Schwartz, Antonio Arrieta, Patricia Flynn, Aziza Shad, Edythe Albano, James J. Keirns, Donald N. Buell, Tawanda Gumbo, George L. Drusano, and Thomas J. Walsh

Population Pharmacokinetics of Micafungin in Pediatric Patients and Implications for Antifungal Dosing
Antimicrob. Agents Chemother. 2007 51: 3714-3719. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anouk E. Muller, Joost DeJongh, Ymka Bult, Wil H. F. Goessens, Johan W. Mouton, Meindert Danhof, and John N. van den Anker

Pharmacokinetics of Penicillin G in Infants with a Gestational Age of Less than 32 Weeks
Antimicrob. Agents Chemother. 2007 51: 3720-3725. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Awadh Bihari Yadav and Amit Misra

Enhancement of Apoptosis of THP-1 Cells Infected with Mycobacterium tuberculosis by Inhalable Microparticles and Relevance to Bactericidal Activity
Antimicrob. Agents Chemother. 2007 51: 3740-3742. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Elio Castagnola, Barbara Cappelli, Maura Faraci, Stefania Fallani, Maria Iris Cassetta, and Andrea Novelli

Maintenance of Therapeutic Concentrations of Caspofungin after Temporary Treatment Interruption (48 Hours) in a Child with Invasive Aspergillosis
Antimicrob. Agents Chemother. 2007 51: 3775. [Full Text] [PDF] [Reprints and Permissions]  

Joanna C. Evans and Heidi Segal

A Novel Insertion Sequence, ISPa26, in oprD of Pseudomonas aeruginosa Is Associated with Carbapenem Resistance
Antimicrob. Agents Chemother. 2007 51: 3776-3777. [Full Text] [PDF] [Reprints and Permissions]  

Sang Hee Lee, Jung Hun Lee, Myong Jin Heo, Il Kwon Bae, Seok Hoon Jeong, Sun-Shin Cha, Jun-ichi Wachino, and Yoshichika Arakawa

Exact Location of the Region Responsible for the Extended Substrate Spectrum in Class C ß-Lactamases
Antimicrob. Agents Chemother. 2007 51: 3778-3779. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.