AAC -- Table of Contents (October 1 2007, 51 [10])

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Contents: October 2007, Volume 51, Issue 10

       Minireviews

       Mechanisms of Action

       Mechanisms of Resistance

       Antiviral Agents

       Clinical Therapeutics

       Chemistry; Biosynthesis

       Susceptibility

       Experimental Therapeutics

       Pharmacology

       Biologic Response Modifiers

       Letters

Other Issues

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To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Minireviews:

Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Federico Perez, Andrea M. Hujer, Kristine M. Hujer, Brooke K. Decker, Philip N. Rather, and Robert A. Bonomo
Antimicrob. Agents Chemother. October 2007 51: 3471-3484; published ahead of print July 23, 2007, doi:10.1128/AAC.01464-06
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Mechanisms of Action:

Multiple Antibiotics Exert Delayed Effects against the Plasmodium falciparum Apicoplast
Erica L. Dahl and Philip J. Rosenthal
Antimicrob. Agents Chemother. October 2007 51: 3485-3490; published ahead of print August 13, 2007, doi:10.1128/AAC.00527-07
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Fatty Acid Synthesis Is Essential for Survival of Cryptococcus neoformans and a Potential Fungicidal Target
Methee Chayakulkeeree, Thomas H. Rude, Dena L. Toffaletti, and John R. Perfect
Antimicrob. Agents Chemother. October 2007 51: 3537-3545; published ahead of print August 13, 2007, doi:10.1128/AAC.00442-07
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Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity InhA Inhibitors
Melissa E. Boyne, Todd J. Sullivan, Christopher W. amEnde, Hao Lu, Veronica Gruppo, Darragh Heaslip, Anita G. Amin, Delphi Chatterjee, Anne Lenaerts, Peter J. Tonge, and Richard A. Slayden
Antimicrob. Agents Chemother. October 2007 51: 3562-3567; published ahead of print July 30, 2007, doi:10.1128/AAC.00383-07
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High-Throughput Screens for Small-Molecule Inhibitors of Pseudomonas aeruginosa Biofilm Development
Lauren M. Junker and Jon Clardy
Antimicrob. Agents Chemother. October 2007 51: 3582-3590; published ahead of print July 30, 2007, doi:10.1128/AAC.00506-07
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Fluorescence Ratio Imaging Microscopy Shows Decreased Access of Vancomycin to Cell Wall Synthetic Sites in Vancomycin-Resistant Staphylococcus aureus
Pedro M. Pereira, Sérgio R. Filipe, Alexander Tomasz, and Mariana G. Pinho
Antimicrob. Agents Chemother. October 2007 51: 3627-3633; published ahead of print July 23, 2007, doi:10.1128/AAC.00431-07
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Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr^–^/^– Mice
Nadine Hoffmann, Baoleri Lee, Morten Hentzer, Thomas Bovbjerg Rasmussen, Zhijun Song, Helle Krogh Johansen, Michael Givskov, and Niels Høiby
Antimicrob. Agents Chemother. October 2007 51: 3677-3687; published ahead of print July 9, 2007, doi:10.1128/AAC.01011-06
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The Antifungal Polyketide Ambruticin Targets the HOG Pathway
Leandro Vetcher, Hugo G. Menzella, Toshiaki Kudo, Takayuki Motoyama, and Leonard Katz
Antimicrob. Agents Chemother. October 2007 51: 3734-3736; published ahead of print August 13, 2007, doi:10.1128/AAC.00369-07
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Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model
Chiatogu Onyewu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, and Joseph Heitman
Antimicrob. Agents Chemother. October 2007 51: 3743-3746; published ahead of print July 30, 2007, doi:10.1128/AAC.00492-07
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The Ssk1p Response Regulator and Chk1p Histidine Kinase Mutants of Candida albicans Are Hypersensitive to Fluconazole and Voriconazole
Neeraj Chauhan, Michael Kruppa, and Richard Calderone
Antimicrob. Agents Chemother. October 2007 51: 3747-3751; published ahead of print July 30, 2007, doi:10.1128/AAC.00929-07
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Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine
Christophe Loup, Joël Lelièvre, Françoise Benoit-Vical, and Bernard Meunier
Antimicrob. Agents Chemother. October 2007 51: 3768-3770; published ahead of print August 13, 2007, doi:10.1128/AAC.00239-07
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Mechanisms of Resistance:

Risk Factors for Development of Multiple-Class Resistance to Streptococcus pneumoniae Strains in Belgium over a 10-Year Period: Antimicrobial Consumption, Population Density, and Geographic Location
Johan Van Eldere, Robertino M. Mera, Linda A. Miller, James A. Poupard, and Heather Amrine-Madsen
Antimicrob. Agents Chemother. October 2007 51: 3491-3497; published ahead of print August 6, 2007, doi:10.1128/AAC.01581-06
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Genetic Analysis of the Dihydrofolate Reductase-Thymidylate Synthase Gene from Geographically Diverse Isolates of Plasmodium malariae
Naowarat Tanomsing, Mallika Imwong, Sasithon Pukrittayakamee, Kesinee Chotivanich, Sornchai Looareesuwan, Mayfong Mayxay, Christiane Dolecek, Tran Tinh Hien, Virgilio E. do Rosario, Ana Paula Arez, Pascal Michon, Georges Snounou, Nicholas J. White, and Nicholas P. J. Day
Antimicrob. Agents Chemother. October 2007 51: 3523-3530; published ahead of print August 6, 2007, doi:10.1128/AAC.00234-07
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Pseudomonas aeruginosa May Accumulate Drug Resistance Mechanisms without Losing Its Ability To Cause Bloodstream Infections
Didier Hocquet, Philippe Berthelot, Micheline Roussel-Delvallez, Roger Favre, Katy Jeannot, Odile Bajolet, Nicole Marty, Florence Grattard, Patricia Mariani-Kurkdjian, Edouard Bingen, Marie-Odile Husson, Gérard Couetdic, and Patrick Plésiat
Antimicrob. Agents Chemother. October 2007 51: 3531-3536; published ahead of print August 6, 2007, doi:10.1128/AAC.00503-07
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Role of the rapA Gene in Controlling Antibiotic Resistance of Escherichia coli Biofilms
S. V. Lynch, L. Dixon, M. R. Benoit, E. L. Brodie, M. Keyhan, P. Hu, D. F. Ackerley, G. L. Andersen, and A. Matin
Antimicrob. Agents Chemother. October 2007 51: 3650-3658; published ahead of print July 30, 2007, doi:10.1128/AAC.00601-07
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Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae
Ling-Xiang Zhu, Zhi-Wei Zhang, Dong Liang, Di Jiang, Can Wang, Ning Du, Qiong Zhang, Keith Mitchelson, and Jing Cheng
Antimicrob. Agents Chemother. October 2007 51: 3707-3713; published ahead of print July 23, 2007, doi:10.1128/AAC.01461-06
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Plasmid-Encoded ACC-4, an Extended-Spectrum Cephalosporinase Variant from Escherichia coli
Costas C. Papagiannitsis, Leonidas S. Tzouvelekis, Eva Tzelepi, and Vivi Miriagou
Antimicrob. Agents Chemother. October 2007 51: 3763-3767; published ahead of print July 30, 2007, doi:10.1128/AAC.00389-07
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Antiviral Agents:

Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro
Leah Tong, Truc K. Phan, Kelly L. Robinson, Darius Babusis, Robert Strab, Siddhartha Bhoopathy, Ismael J. Hidalgo, Gerald R. Rhodes, and Adrian S. Ray
Antimicrob. Agents Chemother. October 2007 51: 3498-3504; published ahead of print July 30, 2007, doi:10.1128/AAC.00671-07
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Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections
George R. Painter, Merrick R. Almond, Lawrence C. Trost, Bernhard M. Lampert, Johan Neyts, Erik De Clercq, Brent E. Korba, Kathy A. Aldern, James R. Beadle, and Karl Y. Hostetler
Antimicrob. Agents Chemother. October 2007 51: 3505-3509; published ahead of print July 23, 2007, doi:10.1128/AAC.00460-07
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Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents
Patricia M. Flynn, John Rodman, Jane C. Lindsey, Brian Robbins, Edmund Capparelli, Katherine M. Knapp, Jose F. Rodriguez, James McNamara, Leslie Serchuck, Barbara Heckman, Jaime Martinez the PACTG P1012 Team
Antimicrob. Agents Chemother. October 2007 51: 3516-3522; published ahead of print July 30, 2007, doi:10.1128/AAC.01626-06
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Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing
Wade S. Blair, Joan Cao, Lynn Jackson, Judith Jimenez, Qinghai Peng, Hua Wu, Jason Isaacson, Scott L. Butler, Alex Chu, Joanne Graham, Anne-Marie Malfait, Micky Tortorella, and Amy K. Patick
Antimicrob. Agents Chemother. October 2007 51: 3554-3561; published ahead of print July 23, 2007, doi:10.1128/AAC.00643-07
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Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen
Lee F. Peng, Sun Suk Kim, Sirinya Matchacheep, Xiaoguang Lei, Shun Su, Wenyu Lin, Weerawat Runguphan, Won-Hyeok Choe, Naoya Sakamoto, Masanori Ikeda, Nobuyuki Kato, Aaron B. Beeler, John A. Porco, Jr., Stuart L. Schreiber, and Raymond T. Chung
Antimicrob. Agents Chemother. October 2007 51: 3756-3759; published ahead of print August 6, 2007, doi:10.1128/AAC.00233-07
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Clinical Therapeutics:

Predictors of 30-Day Mortality among Patients with Pseudomonas aeruginosa Bloodstream Infections: Impact of Delayed Appropriate Antibiotic Selection
Thomas P. Lodise, Jr., Nimish Patel, Andrea Kwa, Jeffrey Graves, Jon P. Furuno, Eileen Graffunder, Ben Lomaestro, and Jessina C. McGregor
Antimicrob. Agents Chemother. October 2007 51: 3510-3515; published ahead of print July 23, 2007, doi:10.1128/AAC.00338-07
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Health Care-Associated Pneumonia and Community-Acquired Pneumonia: a Single-Center Experience
Scott T. Micek, Katherine E. Kollef, Richard M. Reichley, Nareg Roubinian, and Marin H. Kollef
Antimicrob. Agents Chemother. October 2007 51: 3568-3573; published ahead of print August 6, 2007, doi:10.1128/AAC.00851-07
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Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3',3'-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection
Patrick F. Smith, Abayomi Ogundele, Alan Forrest, John Wilton, Karl Salzwedel, Judy Doto, Graham P. Allaway, and David E. Martin
Antimicrob. Agents Chemother. October 2007 51: 3574-3581; published ahead of print July 16, 2007, doi:10.1128/AAC.00152-07
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Targeted Intranasal Mupirocin To Prevent Colonization and Infection by Community-Associated Methicillin-Resistant Staphylococcus aureus Strains in Soldiers: a Cluster Randomized Controlled Trial
Michael W. Ellis, Matthew E. Griffith, David P. Dooley, Joseph C. McLean, James H. Jorgensen, Jan E. Patterson, Kepler A. Davis, Joshua S. Hawley, Jason A. Regules, Robert G. Rivard, Paula J. Gray, Julia M. Ceremuga, Mary A. DeJoseph, and Duane R. Hospenthal
Antimicrob. Agents Chemother. October 2007 51: 3591-3598; published ahead of print August 6, 2007, doi:10.1128/AAC.01086-06
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Phase 2 Study of Ceftaroline versus Standard Therapy in Treatment of Complicated Skin and Skin Structure Infections
George H. Talbot, Dirk Thye, Anita Das, and Yigong Ge
Antimicrob. Agents Chemother. October 2007 51: 3612-3616; published ahead of print August 6, 2007, doi:10.1128/AAC.00590-07
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Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus
Thomas P. Lodise, Jr., Peggy S. McKinnon, Donald P. Levine, and Michael J. Rybak
Antimicrob. Agents Chemother. October 2007 51: 3731-3733; published ahead of print July 30, 2007, doi:10.1128/AAC.00101-07
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Chemistry; Biosynthesis:

Insight into Siderophore-Carrying Peptide Biosynthesis: Enterobactin Is a Precursor for Microcin E492 Posttranslational Modification
Gaëlle Vassiliadis, Jean Peduzzi, Séverine Zirah, Xavier Thomas, Sylvie Rebuffat, and Delphine Destoumieux-Garzón
Antimicrob. Agents Chemother. October 2007 51: 3546-3553; published ahead of print July 23, 2007, doi:10.1128/AAC.00261-07
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Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening
David A. Ostrov, José A. Hernández Prada, Patrick E. Corsino, Kathryn A. Finton, Nhan Le, and Thomas C. Rowe
Antimicrob. Agents Chemother. October 2007 51: 3688-3698; published ahead of print August 6, 2007, doi:10.1128/AAC.00392-07
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Susceptibility:

Correlation of the MIC and Dose/MIC Ratio of Fluconazole to the Therapeutic Response of Patients with Mucosal Candidiasis and Candidemia
Juan L. Rodríguez-Tudela, Benito Almirante, Dolors Rodríguez-Pardo, Fernando Laguna, J. Peter Donnelly, Johan W. Mouton, Albert Pahissa, and Manuel Cuenca-Estrella
Antimicrob. Agents Chemother. October 2007 51: 3599-3604; published ahead of print July 23, 2007, doi:10.1128/AAC.00296-07
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Treatment of a Clinically Relevant Plant-Pathogenic Fungus with an Agricultural Azole Causes Cross-Resistance to Medical Azoles and Potentiates Caspofungin Efficacy
Albrecht Serfling, Johannes Wohlrab, and Holger B. Deising
Antimicrob. Agents Chemother. October 2007 51: 3672-3676; published ahead of print July 9, 2007, doi:10.1128/AAC.00654-07
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Comparative Evaluation of the VITEK 2, Disk Diffusion, Etest, Broth Microdilution, and Agar Dilution Susceptibility Testing Methods for Colistin in Clinical Isolates, Including Heteroresistant Enterobacter cloacae and Acinetobacter baumannii Strains
Jerome R. Lo-Ten-Foe, Anne Marie G. A. de Smet, Bram M. W. Diederen, Jan A. J. W. Kluytmans, and Peter H. J. van Keulen
Antimicrob. Agents Chemother. October 2007 51: 3726-3730; published ahead of print July 23, 2007, doi:10.1128/AAC.01406-06
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Targeting of the Brucella suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen
Pascale Joseph, Marie-Rose Abdo, Rose-Anne Boigegrain, Jean-Louis Montero, Jean-Yves Winum, and Stephan Köhler
Antimicrob. Agents Chemother. October 2007 51: 3752-3755; published ahead of print August 13, 2007, doi:10.1128/AAC.00572-07
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Experimental Therapeutics:

Effect of Dosing and Dosing Frequency on the Efficacy of Ceftizoxime and the Emergence of Ceftizoxime Resistance during the Early Development of Murine Abscesses Caused by Bacteroides fragilis and Enterobacter cloacae Mixed Infection
Lorna E. T. Stearne, Wil H. F. Goessens, Johan W. Mouton, and Inge C. Gyssens
Antimicrob. Agents Chemother. October 2007 51: 3605-3611; published ahead of print July 23, 2007, doi:10.1128/AAC.01486-06
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Reduction of Streptococcus mutans Adherence and Dental Biofilm Formation by Surface Treatment with Phosphorylated Polyethylene Glycol
Akira Shimotoyodome, Takashi Koudate, Hisataka Kobayashi, Junji Nakamura, Ichiro Tokimitsu, Tadashi Hase, Takashi Inoue, Takashi Matsukubo, and Yoshinori Takaesu
Antimicrob. Agents Chemother. October 2007 51: 3634-3641; published ahead of print July 23, 2007, doi:10.1128/AAC.00380-07
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Development of Resistance in Wild-Type and Hypermutable Pseudomonas aeruginosa Strains Exposed to Clinical Pharmacokinetic Profiles of Meropenem and Ceftazidime Simulated In Vitro
Beate Henrichfreise, Irith Wiegand, Ingeborg Luhmer-Becker, and Bernd Wiedemann
Antimicrob. Agents Chemother. October 2007 51: 3642-3649; published ahead of print August 6, 2007, doi:10.1128/AAC.00160-07
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Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase
Wesley C. Van Voorhis, Kasey L. Rivas, Pravin Bendale, Laxman Nallan, Carolyn Hornéy, Lynn K. Barrett, Kevin D. Bauer, Brian P. Smart, Sudha Ankala, Oliver Hucke, Christophe L. M. J. Verlinde, Debopam Chakrabarti, Corey Strickland, Kohei Yokoyama, Frederick S. Buckner, Andrew D. Hamilton, David K. Williams, Louis J. Lombardo, David Floyd, and Michael H. Gelb
Antimicrob. Agents Chemother. October 2007 51: 3659-3671; published ahead of print July 2, 2007, doi:10.1128/AAC.00246-07
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Influence of TEM-1 ß-Lactamase on the Pharmacodynamic Activity of Simulated Total versus Free-Drug Serum Concentrations of Cefditoren (400 Milligrams) versus Amoxicillin-Clavulanic Acid (2,000/125 Milligrams) against Haemophilus influenzae Strains Exhibiting an N526K Mutation in the ftsI Gene
M. Torrico, L. Aguilar, N. González, M. J. Giménez, O. Echeverría, F. Cafini, D. Sevillano, L. Alou, P. Coronel, and J. Prieto
Antimicrob. Agents Chemother. October 2007 51: 3699-3706; published ahead of print July 30, 2007, doi:10.1128/AAC.01530-06
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Orally Administered Combined Regimens for Treatment of Mycobacterium ulcerans Infection in Mice
Baohong Ji, Aurélie Chauffour, Jérôme Robert, Sébastien Lefrançois, and Vincent Jarlier
Antimicrob. Agents Chemother. October 2007 51: 3737-3739; published ahead of print July 30, 2007, doi:10.1128/AAC.00730-07
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Optimization of the Dosage of Flucytosine in Combination with Amphotericin B for Disseminated Candidiasis: a Pharmacodynamic Rationale for Reduced Dosing
William W. Hope, Peter A. Warn, Andrew Sharp, Paul Reed, Brian Keevil, Arnold Louie, Thomas J. Walsh, David W. Denning, and George L. Drusano
Antimicrob. Agents Chemother. October 2007 51: 3760-3762; published ahead of print August 6, 2007, doi:10.1128/AAC.00488-07
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Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung
María José de Jesús Valle, Francisco González López, Alfonso Domínguez-Gil Hurlé, and Amparo Sánchez Navarro
Antimicrob. Agents Chemother. October 2007 51: 3771-3774; published ahead of print August 6, 2007, doi:10.1128/AAC.00099-07
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Pharmacology:

Steady-State Pharmacokinetic and Safety Profiles of Voriconazole and Ritonavir in Healthy Male Subjects
Ping Liu, Grover Foster, Kuan Gandelman, Robert R. LaBadie, Mark J. Allison, Maria J. Gutierrez, and Amarnath Sharma
Antimicrob. Agents Chemother. October 2007 51: 3617-3626; published ahead of print July 23, 2007, doi:10.1128/AAC.00526-07
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Population Pharmacokinetics of Micafungin in Pediatric Patients and Implications for Antifungal Dosing
William W. Hope, Nita L. Seibel, Cindy L. Schwartz, Antonio Arrieta, Patricia Flynn, Aziza Shad, Edythe Albano, James J. Keirns, Donald N. Buell, Tawanda Gumbo, George L. Drusano, and Thomas J. Walsh
Antimicrob. Agents Chemother. October 2007 51: 3714-3719; published ahead of print July 16, 2007, doi:10.1128/AAC.00398-07
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Pharmacokinetics of Penicillin G in Infants with a Gestational Age of Less than 32 Weeks
Anouk E. Muller, Joost DeJongh, Ymka Bult, Wil H. F. Goessens, Johan W. Mouton, Meindert Danhof, and John N. van den Anker
Antimicrob. Agents Chemother. October 2007 51: 3720-3725; published ahead of print July 23, 2007, doi:10.1128/AAC.00318-07
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Biologic Response Modifiers:

Enhancement of Apoptosis of THP-1 Cells Infected with Mycobacterium tuberculosis by Inhalable Microparticles and Relevance to Bactericidal Activity
Awadh Bihari Yadav and Amit Misra
Antimicrob. Agents Chemother. October 2007 51: 3740-3742; published ahead of print July 30, 2007, doi:10.1128/AAC.00925-07
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Letters:

Maintenance of Therapeutic Concentrations of Caspofungin after Temporary Treatment Interruption (48 Hours) in a Child with Invasive Aspergillosis
Elio Castagnola, Barbara Cappelli, Maura Faraci, Stefania Fallani, Maria Iris Cassetta, and Andrea Novelli
Antimicrob. Agents Chemother. October 2007 51: 3775 published ahead of print July 23, 2007, doi:10.1128/AAC.00890-07
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A Novel Insertion Sequence, ISPa26, in oprD of Pseudomonas aeruginosa Is Associated with Carbapenem Resistance
Joanna C. Evans and Heidi Segal
Antimicrob. Agents Chemother. October 2007 51: 3776-3777; published ahead of print August 6, 2007, doi:10.1128/AAC.00837-07
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Exact Location of the Region Responsible for the Extended Substrate Spectrum in Class C ß-Lactamases
Sang Hee Lee, Jung Hun Lee, Myong Jin Heo, Il Kwon Bae, Seok Hoon Jeong, Sun-Shin Cha, Jun-ichi Wachino, and Yoshichika Arakawa
Antimicrob. Agents Chemother. October 2007 51: 3778-3779;
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To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.