Contents: November 2007, Volume 51, Issue 11        Experimental Therapeutics        Mechanisms of Resistance        Susceptibility        Mechanisms of Action        Antiviral Agents        Chemistry; Biosynthesis        Clinical Therapeutics        Pharmacology Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Experimental Therapeutics:

---

Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin Tawanda Gumbo, Arnold Louie, Mark R. Deziel, Weiguo Liu, Linda M. Parsons, Max Salfinger, and George L. Drusano Antimicrob. Agents Chemother. November 2007 51: 3781-3788; published ahead of print August 27, 2007, doi:10.1128/AAC.01533-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Assessment Based on Mutant Prevention Concentrations of Fluoroquinolones To Prevent the Emergence of Resistant Mutants of Streptococcus pneumoniae Tomoyuki Homma, Toshihiko Hori, Giichi Sugimori, and Yoshinori Yamano Antimicrob. Agents Chemother. November 2007 51: 3810-3815; published ahead of print July 30, 2007, doi:10.1128/AAC.01372-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dietary Inclusion of Colicin E1 Is Effective in Preventing Postweaning Diarrhea Caused by F18-Positive Escherichia coli in Pigs S. A. Cutler, S. M. Lonergan, N. Cornick, A. K. Johnson, and C. H. Stahl Antimicrob. Agents Chemother. November 2007 51: 3830-3835; published ahead of print August 27, 2007, doi:10.1128/AAC.00360-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Cysteine Protease Inhibitor Cures Chagas' Disease in an Immunodeficient-Mouse Model of Infection Patricia S. Doyle, Yuan M. Zhou, Juan C. Engel, and James H. McKerrow Antimicrob. Agents Chemother. November 2007 51: 3932-3939; published ahead of print August 13, 2007, doi:10.1128/AAC.00436-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Novel Fluoroquinolones Alone and in Combination with Clarithromycin against Clinically Isolated Mycobacterium avium Complex Strains in Japan Yoshihisa Kohno, Hideaki Ohno, Yoshitsugu Miyazaki, Yasuhito Higashiyama, Katsunori Yanagihara, Yoichi Hirakata, Kiyoyasu Fukushima, and Shigeru Kohno Antimicrob. Agents Chemother. November 2007 51: 4071-4076; published ahead of print August 20, 2007, doi:10.1128/AAC.00410-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Effect of Halocidin-Derived Peptide in a Mouse Model of Listeria Infection Woong Sik Jang, Sang-Chul Lee, Young Shin Lee, Yong Pyo Shin, Kyoung Hwa Shin, Boo Hee Sung, Byung S. Kim, Soo Han Lee, and In Hee Lee Antimicrob. Agents Chemother. November 2007 51: 4148-4156; published ahead of print September 10, 2007, doi:10.1128/AAC.00635-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Resistance:

---

Complete Nucleotide Sequence of the pCTX-M3 Plasmid and Its Involvement in Spread of the Extended-Spectrum ß-Lactamase Gene blaCTX-M-3 M. Golebiewski, I. Kern-Zdanowicz, M. Zienkiewicz, M. Adamczyk, J. Zylinska, A. Baraniak, M. Gniadkowski, J. Bardowski, and P. Ceglowski Antimicrob. Agents Chemother. November 2007 51: 3789-3795; published ahead of print August 13, 2007, doi:10.1128/AAC.00457-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Characterization of TcaA: Minimal Requirement for Teicoplanin Susceptibility and Role in Caenorhabditis elegans Virulence Nadine McCallum, Ann Karen C. Brassinga, Costi D. Sifri, and Brigitte Berger-Bächi Antimicrob. Agents Chemother. November 2007 51: 3836-3843; published ahead of print August 20, 2007, doi:10.1128/AAC.00722-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

An OXA-66/OXA-51-Like Carbapenemase and Possibly an Efflux Pump Are Associated with Resistance to Imipenem in Acinetobacter baumannii Wensi S. Hu, Shu-Man Yao, Chang-Phone Fung, Yi-Ping Hsieh, Chang-Pan Liu, and Jing-Fang Lin Antimicrob. Agents Chemother. November 2007 51: 3844-3852; published ahead of print August 27, 2007, doi:10.1128/AAC.01512-06 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Mupirocin-Resistant, Methicillin-Resistant Staphylococcus aureus Strains in Canadian Hospitals Andrew E. Simor, Tammy L. Stuart, Lisa Louie, Christine Watt, Marianne Ofner-Agostini, Denise Gravel, Michael Mulvey, Mark Loeb, Allison McGeer, Elizabeth Bryce, Anne Matlow and the Canadian Nosocomial Infection Surveillance Program Antimicrob. Agents Chemother. November 2007 51: 3880-3886; published ahead of print August 27, 2007, doi:10.1128/AAC.00846-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Characteristics and Clonal Dissemination of ß-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae Strains Isolated from the Upper Respiratory Tract of Patients in Japan Muneki Hotomi, Keiji Fujihara, Dewan S. Billal, Kenji Suzuki, Tadao Nishimura, Shunkichi Baba, and Noboru Yamanaka Antimicrob. Agents Chemother. November 2007 51: 3969-3976; published ahead of print August 13, 2007, doi:10.1128/AAC.00422-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Composite Structure of Streptococcus pneumoniae Containing the Erythromycin Efflux Resistance Gene mef(I) and the Chloramphenicol Resistance Gene catQ Marina Mingoia, Manuela Vecchi, Ileana Cochetti, Emily Tili, Luca A. Vitali, Aldo Manzin, Pietro E. Varaldo, and Maria Pia Montanari Antimicrob. Agents Chemother. November 2007 51: 3983-3987; published ahead of print August 20, 2007, doi:10.1128/AAC.00790-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae Arnold Louie, David L. Brown, Weiguo Liu, Robert W. Kulawy, Mark R. Deziel, and George L. Drusano Antimicrob. Agents Chemother. November 2007 51: 3988-4000; published ahead of print September 10, 2007, doi:10.1128/AAC.00391-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular and Biochemical Characterization of the Chromosome-Encoded Class A ß-Lactamase BCL-1 from Bacillus clausii Delphine Girlich, Roland Leclercq, Thierry Naas, and Patrice Nordmann Antimicrob. Agents Chemother. November 2007 51: 4009-4014; published ahead of print September 10, 2007, doi:10.1128/AAC.00537-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Report of the Emergence of CTX-M-Type Extended-Spectrum ß-Lactamases (ESBLs) as the Predominant ESBL Isolated in a U.S. Health Care System James S. Lewis, II, Monica Herrera, Brian Wickes, Jan E. Patterson, and James H. Jorgensen Antimicrob. Agents Chemother. November 2007 51: 4015-4021; published ahead of print August 27, 2007, doi:10.1128/AAC.00576-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant Acinetobacter spp. from Chinese Hospitals Hui Wang, Ping Guo, Hongli Sun, He Wang, Qiwen Yang, Minjun Chen, Yingchun Xu, and Yuanjue Zhu Antimicrob. Agents Chemother. November 2007 51: 4022-4028; published ahead of print September 10, 2007, doi:10.1128/AAC.01259-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance Mechanisms of Multiresistant Pseudomonas aeruginosa Strains from Germany and Correlation with Hypermutation B. Henrichfreise, I. Wiegand, W. Pfister, and B. Wiedemann Antimicrob. Agents Chemother. November 2007 51: 4062-4070; published ahead of print September 17, 2007, doi:10.1128/AAC.00148-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Prevalence and Expression of the Plasmid-Mediated Quinolone Resistance Determinant qnrA1 Xiaogang Xu, Shi Wu, Xinyu Ye, Yang Liu, Wanliang Shi, Yingyuan Zhang, and Minggui Wang Antimicrob. Agents Chemother. November 2007 51: 4105-4110; published ahead of print August 27, 2007, doi:10.1128/AAC.00616-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

vanD and vanG-Like Gene Clusters in a Ruminococcus Species Isolated from Human Bowel Flora M.-C. Domingo, A. Huletsky, R. Giroux, F. J. Picard, and M. G. Bergeron Antimicrob. Agents Chemother. November 2007 51: 4111-4117; published ahead of print August 27, 2007, doi:10.1128/AAC.00584-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Inoculum Size on the Selection of Resistant Mutants of Escherichia coli in Relation to Mutant Prevention Concentrations of Marbofloxacin Aude Ferran, Véronique Dupouy, Pierre-Louis Toutain, and Alain Bousquet-Mélou Antimicrob. Agents Chemother. November 2007 51: 4163-4166; published ahead of print August 20, 2007, doi:10.1128/AAC.00156-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of the Quinolone Resistance-Mediating Gene aac(6')-Ib-cr in Extended-Spectrum-ß-Lactamase-Producing Klebsiella Isolates Collected in Slovenia between 2000 and 2005 Jerneja Ambrozic Avgustin, Rok Keber, Katja Zerjavic, Toni Orazem, and Miklavz Grabnar Antimicrob. Agents Chemother. November 2007 51: 4171-4173; published ahead of print September 10, 2007, doi:10.1128/AAC.01480-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus Eleusa Maria F. Rocha, Guillermo Garcia-Effron, Steven Park, and David S. Perlin Antimicrob. Agents Chemother. November 2007 51: 4174-4176; published ahead of print August 27, 2007, doi:10.1128/AAC.00917-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Analysis of IncHI2 Plasmids Carrying blaCTX-M-2 or blaCTX-M-9 from Escherichia coli and Salmonella enterica Strains Isolated from Poultry and Humans Aurora García Fernández, Axel Cloeckaert, Alessia Bertini, Karine Praud, Benoît Doublet, François-Xavier Weill, and Alessandra Carattoli Antimicrob. Agents Chemother. November 2007 51: 4177-4180; published ahead of print August 13, 2007, doi:10.1128/AAC.00603-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

TEM-158 (CMT-9), a New Member of the CMT-Type Extended-Spectrum ß-Lactamases Frédéric Robin, Julien Delmas, Amélie Brebion, Damien Dubois, Jean-Michel Constantin, and Richard Bonnet Antimicrob. Agents Chemother. November 2007 51: 4181-4183; published ahead of print August 20, 2007, doi:10.1128/AAC.00614-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Macrolide Resistance Genes erm(B) and mef(E) Are Carried by Tn2010 in Dual-Gene Streptococcus pneumoniae Isolates Belonging to Clonal Complex CC271 Maria Del Grosso, John G. E. Northwood, David J. Farrell, and Annalisa Pantosti Antimicrob. Agents Chemother. November 2007 51: 4184-4186; published ahead of print August 20, 2007, doi:10.1128/AAC.00598-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tn6001, a Transposon-Like Element Containing the blaVIM-3-Harboring Integron In450 Sung-Pin Tseng, Po-Ren Hsueh, Jui-Chang Tsai, and Lee-Jene Teng Antimicrob. Agents Chemother. November 2007 51: 4187-4190; published ahead of print September 10, 2007, doi:10.1128/AAC.00542-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antistaphylococcal Activity of CG400549, a New Experimental FabI Inhibitor, Compared with That of Other Agents Tatiana Bogdanovich, Catherine Clark, Klaudia Kosowska-Shick, Bonifacio Dewasse, Pamela McGhee, and Peter C. Appelbaum Antimicrob. Agents Chemother. November 2007 51: 4191-4195; published ahead of print September 17, 2007, doi:10.1128/AAC.00550-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies Catherine L. Clark, Klaudia Kosowska-Shick, Lois M. Ednie, and Peter C. Appelbaum Antimicrob. Agents Chemother. November 2007 51: 4196-4201; published ahead of print September 17, 2007, doi:10.1128/AAC.00827-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Contributions of the Combined Effects of Topoisomerase Mutations toward Fluoroquinolone Resistance in Escherichia coli Sonia K. Morgan-Linnell and Lynn Zechiedrich Antimicrob. Agents Chemother. November 2007 51: 4205-4208; published ahead of print August 6, 2007, doi:10.1128/AAC.00647-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of 16S rRNA Methylase-Producing Acinetobacter baumannii Clinical Strains in North America Yohei Doi, Jennifer M. Adams, Kunikazu Yamane, and David L. Paterson Antimicrob. Agents Chemother. November 2007 51: 4209-4210; published ahead of print September 4, 2007, doi:10.1128/AAC.00560-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

2,N6-Disubstituted Adenosine Analogs with Antitrypanosomal and Antimalarial Activities Boris Rodenko, Alida M. van der Burg, Martin J. Wanner, Marcel Kaiser, Reto Brun, Matthew Gould, Harry P. de Koning, and Gerrit-Jan Koomen Antimicrob. Agents Chemother. November 2007 51: 3796-3802; published ahead of print August 13, 2007, doi:10.1128/AAC.00425-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

In Vitro Activity of Human ß-Defensin 2 against Pseudomonas aeruginosa in the Presence of Tear Fluid Ling C. Huang, Rachel L. Redfern, Srihari Narayanan, Rose Y. Reins, and Alison M. McDermott Antimicrob. Agents Chemother. November 2007 51: 3853-3860; published ahead of print August 27, 2007, doi:10.1128/AAC.01317-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinuclidine Derivatives as Potential Antiparasitics Simon B. Cammerer, Carmen Jimenez, Simon Jones, Ludovic Gros, Silvia Orenes Lorente, Carlos Rodrigues, Juliany C. F. Rodrigues, Aura Caldera, Luis Miguel Ruiz Perez, Wanderley da Souza, Marcel Kaiser, Reto Brun, Julio A. Urbina, Dolores Gonzalez Pacanowska, and Ian H. Gilbert Antimicrob. Agents Chemother. November 2007 51: 4049-4061; published ahead of print August 20, 2007, doi:10.1128/AAC.00205-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of an Antimicrobial Peptide Mimetic against Planktonic and Biofilm Cultures of Oral Pathogens Nicholas Beckloff, Danielle Laube, Tammy Castro, David Furgang, Steven Park, David Perlin, Dylan Clements, Haizhong Tang, Richard W. Scott, Gregory N. Tew, and Gill Diamond Antimicrob. Agents Chemother. November 2007 51: 4125-4132; published ahead of print September 4, 2007, doi:10.1128/AAC.00208-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Design, Synthesis, and Evaluation of 10-N-Substituted Acridones as Novel Chemosensitizers in Plasmodium falciparum Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, and Michael Riscoe Antimicrob. Agents Chemother. November 2007 51: 4133-4140; published ahead of print September 10, 2007, doi:10.1128/AAC.00669-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Resistance and Single-Nucleotide Polymorphism Cluster Grouping Type in a Multinational Sample of Resistant Mycobacterium tuberculosis Isolates M. Brimacombe, M. Hazbon, A. S. Motiwala, and D. Alland Antimicrob. Agents Chemother. November 2007 51: 4157-4159; published ahead of print September 10, 2007, doi:10.1128/AAC.00619-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Galanin Message-Associated Peptide Suppresses Growth and the Budded-to-Hyphal-Form Transition of Candida albicans Isabella Rauch, Linda Lundström, Markus Hell, Wolfgang Sperl, and Barbara Kofler Antimicrob. Agents Chemother. November 2007 51: 4167-4170; published ahead of print August 13, 2007, doi:10.1128/AAC.00166-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimycobacterial Spectrum of a Diarylquinoline ATP Synthase Inhibitor Emma Huitric, Peter Verhasselt, Koen Andries, and Sven E. Hoffner Antimicrob. Agents Chemother. November 2007 51: 4202-4204; published ahead of print August 20, 2007, doi:10.1128/AAC.00181-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Serum on In Vitro Susceptibility Testing of Echinocandins Zekaver Odabasi, Victor Paetznick, John H. Rex, and Luis Ostrosky-Zeichner Antimicrob. Agents Chemother. November 2007 51: 4214-4216; published ahead of print September 4, 2007, doi:10.1128/AAC.01589-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Cellular Effects of Reversed Amidines on Trypanosoma cruzi C. F. Silva, M. B. Meuser, E. M. De Souza, M. N. L. Meirelles, C. E. Stephens, P. Som, D. W. Boykin, and M. N. C. Soeiro Antimicrob. Agents Chemother. November 2007 51: 3803-3809; published ahead of print August 13, 2007, doi:10.1128/AAC.00047-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Artemisinin-Resistant Mutants of Toxoplasma gondii Have Altered Calcium Homeostasis Kisaburo Nagamune, Silvia N. J. Moreno, and L. David Sibley Antimicrob. Agents Chemother. November 2007 51: 3816-3823; published ahead of print August 13, 2007, doi:10.1128/AAC.00582-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis Jana Korduláková, Yves L. Janin, Avraham Liav, Nathalie Barilone, Tiago Dos Vultos, Jean Rauzier, Patrick J. Brennan, Brigitte Gicquel, and Mary Jackson Antimicrob. Agents Chemother. November 2007 51: 3824-3829; published ahead of print September 4, 2007, doi:10.1128/AAC.00433-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Adenosine Kinase of Trypanosoma brucei and Its Role in Susceptibility to Adenosine Antimetabolites Alexandra Lüscher, Pinar Önal, Anne-Marie Schweingruber, and Pascal Mäser Antimicrob. Agents Chemother. November 2007 51: 3895-3901; published ahead of print August 13, 2007, doi:10.1128/AAC.00458-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for Its High Antimicrobial Activity Mototsugu Yamada, Takashi Watanabe, Takako Miyara, Nobuyoshi Baba, Jun Saito, Yasuo Takeuchi, and Fukuichi Ohsawa Antimicrob. Agents Chemother. November 2007 51: 3902-3907; published ahead of print August 27, 2007, doi:10.1128/AAC.00743-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Polymyxin B Induces Lysis of Marine Pseudoalteromonads Mart Krupovic, Rimantas Daugelavicius, and Dennis H. Bamford Antimicrob. Agents Chemother. November 2007 51: 3908-3914; published ahead of print August 20, 2007, doi:10.1128/AAC.00449-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Global Phenotype Screening and Transcript Analysis Outlines the Inhibitory Mode(s) of Action of Two Amphibian-Derived, -Helical, Cationic Peptides on Saccharomyces cerevisiae C. Oliver Morton, Andrew Hayes, Michael Wilson, Bharat M. Rash, Stephen G. Oliver, and Peter Coote Antimicrob. Agents Chemother. November 2007 51: 3948-3959; published ahead of print September 10, 2007, doi:10.1128/AAC.01007-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Antiproliferative Effect of Dihydroxyacetone on Trypanosoma brucei Bloodstream Forms: Cell Cycle Progression, Subcellular Alterations, and Cell Death Néstor L. Uzcátegui, Didac Carmona-Gutiérrez, Viola Denninger, Caroline Schoenfeld, Florian Lang, Katherine Figarella, and Michael Duszenko Antimicrob. Agents Chemother. November 2007 51: 3960-3968; published ahead of print August 6, 2007, doi:10.1128/AAC.00423-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Caspofungin on Metabolite Profiles of Aspergillus Species Determined by Nuclear Magnetic Resonance Spectroscopy R. Plummer, J. Bodkin, D. Power, N. Pantarat, W. A. Bubb, P. W. Kuchel, and T. C. Sorrell Antimicrob. Agents Chemother. November 2007 51: 4077-4084; published ahead of print September 4, 2007, doi:10.1128/AAC.00602-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Variations in Reverse Transcriptase and RNase H Domain Mutations in Human Immunodeficiency Virus Type 1 Clinical Isolates Are Associated with Divergent Phenotypic Resistance to Zidovudine Michel Ntemgwa, Mark A. Wainberg, Maureen Oliveira, Daniela Moisi, Richard Lalonde, Valeria Micheli, and Bluma G. Brenner Antimicrob. Agents Chemother. November 2007 51: 3861-3869; published ahead of print August 27, 2007, doi:10.1128/AAC.00646-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Metabolism and Persistence of the Anti-Human Immunodeficiency Virus Activity of 2',3'-Didehydro-3'-Deoxy-4'-Ethynylthymidine, a Novel Thymidine Analog Elijah Paintsil, Ginger E. Dutschman, Rong Hu, Susan P. Grill, Wing Lam, Masanori Baba, Hiromichi Tanaka, and Yung-Chi Cheng Antimicrob. Agents Chemother. November 2007 51: 3870-3879; published ahead of print August 27, 2007, doi:10.1128/AAC.00692-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cyclic Tetrapyrrole Sulfonation, Metals, and Oligomerization in Antiprion Activity Winslow S. Caughey, Suzette A. Priola, David A. Kocisko, Lynne D. Raymond, Anne Ward, and Byron Caughey Antimicrob. Agents Chemother. November 2007 51: 3887-3894; published ahead of print August 20, 2007, doi:10.1128/AAC.01599-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus Cheng-Wei Yang, Yung-Ning Yang, Po-Huang Liang, Chi-Min Chen, Wei-Liang Chen, Hwan-You Chang, Yu-Sheng Chao, and Shiow-Ju Lee Antimicrob. Agents Chemother. November 2007 51: 3924-3931; published ahead of print August 20, 2007, doi:10.1128/AAC.00408-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Oral Treatment with Hexadecyloxypropyl-[(S)-9-(3-Hydroxy-2- Phosphonylmethoxypropyl)Adenine] [(S)-HPMPA] or Octadecyloxyethyl-(S)-HPMPA on Cowpox or Vaccinia Virus Infections in Mice Debra C. Quenelle, Deborah J. Collins, Bridgett P. Herrod, Kathy A. Keith, Julissa Trahan, James R. Beadle, Karl Y. Hostetler, and Earl R. Kern Antimicrob. Agents Chemother. November 2007 51: 3940-3947; published ahead of print September 10, 2007, doi:10.1128/AAC.00184-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Immunogenicities of Frozen and Refrigerated Formulations of Live Attenuated Influenza Vaccine in Healthy Subjects Stan L. Block, Keith S. Reisinger, Micki Hultquist, Robert E. Walker for the CAIV-T Study Group Antimicrob. Agents Chemother. November 2007 51: 4001-4008; published ahead of print August 27, 2007, doi:10.1128/AAC.00517-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Novel Protease Inhibitor of Human Immunodeficiency Virus Type 1 Serge Dandache, Guy Sévigny, Jocelyn Yelle, Brent R. Stranix, Neil Parkin, Jonathan M. Schapiro, Mark A. Wainberg, and Jinzi J. Wu Antimicrob. Agents Chemother. November 2007 51: 4036-4043; published ahead of print July 16, 2007, doi:10.1128/AAC.00149-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses Debra C. Quenelle, Mark N. Prichard, Kathy A. Keith, Dennis E. Hruby, Robert Jordan, George R. Painter, Alice Robertson, and Earl R. Kern Antimicrob. Agents Chemother. November 2007 51: 4118-4124; published ahead of print August 27, 2007, doi:10.1128/AAC.00762-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiprion Activity of Cholesterol Esterification Modulators: a Comparative Study Using Ex Vivo Sheep Fibroblasts and Lymphocytes and Mouse Neuroblastoma Cell Lines Alessandra Pani, Claudia Norfo, Claudia Abete, Claudia Mulas, Marirosa Putzolu, Sergio Laconi, Christina Doriana Orrù, M. Dolores Cannas, Sarah Vascellari, Paolo La Colla, and Sandra Dessì Antimicrob. Agents Chemother. November 2007 51: 4141-4147; published ahead of print August 20, 2007, doi:10.1128/AAC.00524-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Growth and Drug Resistance Phenotypes Resulting from Cytomegalovirus DNA Polymerase Region III Mutations Observed in Clinical Specimens Sunwen Chou, Gail I. Marousek, Laura C. Van Wechel, Shaobing Li, and Adriana Weinberg Antimicrob. Agents Chemother. November 2007 51: 4160-4162; published ahead of print August 20, 2007, doi:10.1128/AAC.00736-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Chemistry; Biosynthesis:

---

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography Larissa M. Podust, Jens P. von Kries, Ali Nasser Eddine, Youngchang Kim, Liudmila V. Yermalitskaya, Ronald Kuehne, Hugues Ouellet, Thulasi Warrier, Markus Alteköster, Jong-Seok Lee, Jörg Rademann, Hartmut Oschkinat, Stefan H. E. Kaufmann, and Michael R. Waterman Antimicrob. Agents Chemother. November 2007 51: 3915-3923; published ahead of print September 10, 2007, doi:10.1128/AAC.00311-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

Comparison of ß-Lactam and Macrolide Combination Therapy versus Fluoroquinolone Monotherapy in Hospitalized Veterans Affairs Patients with Community-Acquired Pneumonia Thomas P. Lodise, Andrea Kwa, Leon Cosler, Reetu Gupta, and Raymond P. Smith Antimicrob. Agents Chemother. November 2007 51: 3977-3982; published ahead of print August 20, 2007, doi:10.1128/AAC.00006-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Promising Clinical Efficacy of Streptomycin-Rifampin Combination for Treatment of Buruli Ulcer (Mycobacterium ulcerans Disease) Annick Chauty, Marie-Françoise Ardant, Ambroise Adeye, Hélène Euverte, Augustin Guédénon, Christian Johnson, Jacques Aubry, Eric Nuermberger, and Jacques Grosset Antimicrob. Agents Chemother. November 2007 51: 4029-4035; published ahead of print May 25, 2007, doi:10.1128/AAC.00175-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Randomized, Double-Blind, Placebo-Controlled Trial of Cephalexin for Treatment of Uncomplicated Skin Abscesses in a Population at Risk for Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection Priya M. Rajendran, David Young, Toby Maurer, Henry Chambers, Francoise Perdreau-Remington, Peter Ro, and Hobart Harris Antimicrob. Agents Chemother. November 2007 51: 4044-4048; published ahead of print September 10, 2007, doi:10.1128/AAC.00377-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical and Pharmacological Determinants of the Therapeutic Response to Dihydroartemisinin-Piperaquine for Drug-Resistant Malaria R. N. Price, A. R. Hasugian, A. Ratcliff, H. Siswantoro, H. L. E. Purba, E. Kenangalem, N. Lindegardh, P. Penttinen, F. Laihad, E. P. Ebsworth, N. M. Anstey, and E. Tjitra Antimicrob. Agents Chemother. November 2007 51: 4090-4097; published ahead of print September 10, 2007, doi:10.1128/AAC.00486-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Evaluation of Tigecycline Penetration into Colon Wall Tissue and Epithelial Lining Fluid Using a Population Pharmacokinetic Model and Monte Carlo Simulation Christopher M. Rubino, Lei Ma, Sujata M. Bhavnani, Joan Korth-Bradley, John Speth, Evelyn Ellis-Grosse, Keith R. Rodvold, Paul G. Ambrose, and George L. Drusano Antimicrob. Agents Chemother. November 2007 51: 4085-4089; published ahead of print September 10, 2007, doi:10.1128/AAC.00065-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction Study of the Combined Use of Paroxetine and Fosamprenavir-Ritonavir in Healthy Subjects Manon J. van der Lee, Audrey A. M. Blenke, Gerard A. Rongen, Corrien P. W. G. M. Verwey-van Wissen, Peter P. Koopmans, Cristina Pharo, and David M. Burger Antimicrob. Agents Chemother. November 2007 51: 4098-4104; published ahead of print September 10, 2007, doi:10.1128/AAC.01243-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penetration of Amphotericin B Lipid Formulations into Pleural Effusion Stefan Weiler, Rosa Bellmann-Weiler, Michael Joannidis, and Romuald Bellmann Antimicrob. Agents Chemother. November 2007 51: 4211-4213; published ahead of print September 4, 2007, doi:10.1128/AAC.01087-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.