AAC -- Table of Contents (February 1 2007, 51 [2])

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Contents: February 2007, Volume 51, Issue 2

       Antiviral Agents

       Mechanisms of Resistance

       Clinical Therapeutics

       Mechanisms of Action

       Experimental Therapeutics

       Susceptibility

       Pharmacology

       Analytical Procedures

       Letters

Other Issues

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Antiviral Agents:

Quantitative Immunoassay To Measure Plasma and Intracellular Atazanavir Levels: Analysis of Drug Accumulation in Cultured T Cells
Camille Roucairol, Stéphane Azoulay, Marie-Claire Nevers, Christophe Créminon, Thibault Lavrut, Rodolphe Garraffo, Jacques Grassi, Alain Burger, and Danièle Duval
Antimicrob. Agents Chemother. February 2007 51: 405-411; published ahead of print November 20, 2006, doi:10.1128/AAC.00730-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Nonnucleoside Analogue That Inhibits Human Immunodeficiency Virus Type 1 Isolates Resistant to Current Nonnucleoside Reverse Transcriptase Inhibitors
Zhijun Zhang, Wen Xu, Yung-Hyo Koh, Jae Hoon Shim, Jean-Luc Girardet, Li-Tain Yeh, Robert K. Hamatake, and Zhi Hong
Antimicrob. Agents Chemother. February 2007 51: 429-437; published ahead of print November 20, 2006, doi:10.1128/AAC.01032-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Activation of ß-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase
Eisuke Murakami, Haiying Bao, Mangala Ramesh, Tamara R. McBrayer, Tony Whitaker, Holly M. Micolochick Steuer, Raymond F. Schinazi, Lieven J. Stuyver, Aleksandr Obikhod, Michael J. Otto, and Phillip A. Furman
Antimicrob. Agents Chemother. February 2007 51: 503-509; published ahead of print November 13, 2006, doi:10.1128/AAC.00400-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131
Gabriel Birkus, Ruth Wang, Xiaohong Liu, Nilima Kutty, Holly MacArthur, Tomas Cihlar, Craig Gibbs, Swami Swaminathan, William Lee, and Martin McDermott
Antimicrob. Agents Chemother. February 2007 51: 543-550; published ahead of print December 4, 2006, doi:10.1128/AAC.00968-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development and Characterization of a Novel Single-Cycle Recombinant-Virus Assay To Determine Human Immunodeficiency Virus Type 1 Coreceptor Tropism
Jeannette M. Whitcomb, Wei Huang, Signe Fransen, Kay Limoli, Jonathan Toma, Terri Wrin, Colombe Chappey, Linda D. B. Kiss, Ellen E. Paxinos, and Christos J. Petropoulos
Antimicrob. Agents Chemother. February 2007 51: 566-575; published ahead of print November 20, 2006, doi:10.1128/AAC.00853-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Site-Specific Reduction of Oxidative and Lipid Metabolism in Adipose Tissue of 3'-Azido-3'-Deoxythymidine-Treated Rats
Catherine Deveaud, Bertrand Beauvoit, Annabel Reynaud, and Jacques Bonnet
Antimicrob. Agents Chemother. February 2007 51: 583-590; published ahead of print December 11, 2006, doi:10.1128/AAC.01078-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Natural Polymorphisms in the Human Immunodeficiency Virus Type 2 Protease Can Accelerate Time to Development of Resistance to Protease Inhibitors
Michel Ntemgwa, Bluma G. Brenner, Maureen Oliveira, Daniela Moisi, and Mark A. Wainberg
Antimicrob. Agents Chemother. February 2007 51: 604-610; published ahead of print November 20, 2006, doi:10.1128/AAC.00870-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Activities of Novel 5-Phosphono-Pent-2-en-1-yl Nucleosides and Their Alkoxyalkyl Phosphonoesters
Hyunah Choo, James R. Beadle, Earl R. Kern, Mark N. Prichard, Kathy A. Keith, Caroll B. Hartline, Julissa Trahan, Kathy A. Aldern, Brent E. Korba, and Karl Y. Hostetler
Antimicrob. Agents Chemother. February 2007 51: 611-615; published ahead of print November 27, 2006, doi:10.1128/AAC.00444-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of a New Methodology for Screening of Human Immunodeficiency Virus Type 1 Microbicides Based on Real-Time PCR Quantification
Renato S. Aguiar, Luciana J. Costa, Helena S. Pereira, Rodrigo M. Brindeiro, and Amilcar Tanuri
Antimicrob. Agents Chemother. February 2007 51: 638-644; published ahead of print November 20, 2006, doi:10.1128/AAC.00749-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice
Debra C. Quenelle, R. M. L. Buller, Scott Parker, Kathy A. Keith, Dennis E. Hruby, Robert Jordan, and Earl R. Kern
Antimicrob. Agents Chemother. February 2007 51: 689-695; published ahead of print November 20, 2006, doi:10.1128/AAC.00879-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isolation and Characterization of Human Immunodeficiency Virus Type 1 Resistant to the Small-Molecule CCR5 Antagonist TAK-652
Masanori Baba, Hiroshi Miyake, Xin Wang, Mika Okamoto, and Katsunori Takashima
Antimicrob. Agents Chemother. February 2007 51: 707-715; published ahead of print November 20, 2006, doi:10.1128/AAC.01079-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Structural Characterization of I84C and I84A Mutations That Are Associated with High-Level Resistance to Human Immunodeficiency Virus Protease Inhibitors and Impair Viral Replication
Hongmei Mo, Neil Parkin, Kent D. Stewart, Liangjun Lu, Tatyana Dekhtyar, Dale J. Kempf, and Akhteruzzaman Molla
Antimicrob. Agents Chemother. February 2007 51: 732-735; published ahead of print November 13, 2006, doi:10.1128/AAC.00690-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Interactions of the Antiretroviral Protease Inhibitors Saquinavir and Ritonavir with Chloroquine and Mefloquine against Plasmodium falciparum In Vitro
T. S. Skinner-Adams, K. T. Andrews, L. Melville, J. McCarthy, and D. L. Gardiner
Antimicrob. Agents Chemother. February 2007 51: 759-762; published ahead of print November 6, 2006, doi:10.1128/AAC.00840-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Safety of Indinavir in Human Immunodeficiency Virus-Infected Pregnant Women
Jashvant D. Unadkat, Diane W. Wara, Michael D. Hughes, Anita A. Mathias, Diane T. Holland, Mary E. Paul, James Connor, Sharon Huang, Bach-Yen Nguyen, D. Heather Watts, Lynne M. Mofenson, Elizabeth Smith, Paul Deutsch, Kathleen A. Kaiser, and Ruth E. Tuomala
Antimicrob. Agents Chemother. February 2007 51: 783-786; published ahead of print December 11, 2006, doi:10.1128/AAC.00420-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

Fitness Costs of Fluoroquinolone Resistance in Streptococcus pneumoniae
Daniel E. Rozen, Lesley McGee, Bruce R. Levin, and Keith P. Klugman
Antimicrob. Agents Chemother. February 2007 51: 412-416; published ahead of print November 20, 2006, doi:10.1128/AAC.01161-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of Ampicillin Resistance Genes and Antimicrobial Susceptibility Patterns in Haemophilus influenzae Strains Isolated in Korea
In-Suk Kim, Chang-Seok Ki, Sunjoo Kim, Won Sup Oh, Kyong Ran Peck, Jae-Hoon Song, Kyungwon Lee, and Nam Yong Lee
Antimicrob. Agents Chemother. February 2007 51: 453-460; published ahead of print November 20, 2006, doi:10.1128/AAC.00960-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lysostaphin-Resistant Variants of Staphylococcus aureus Demonstrate Reduced Fitness In Vitro and In Vivo
Caroline Kusuma, Anna Jadanova, Tanya Chanturiya, and John F. Kokai-Kun
Antimicrob. Agents Chemother. February 2007 51: 475-482; published ahead of print November 13, 2006, doi:10.1128/AAC.00786-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

IS21-558 Insertion Sequences Are Involved in the Mobility of the Multiresistance Gene cfr
Corinna Kehrenberg, Frank M. Aarestrup, and Stefan Schwarz
Antimicrob. Agents Chemother. February 2007 51: 483-487; published ahead of print December 4, 2006, doi:10.1128/AAC.01340-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of Target Gene Mutations and Efflux to Decreased Susceptibility of Salmonella enterica Serovar Typhimurium to Fluoroquinolones and Other Antimicrobials
Sheng Chen, Shenghui Cui, Patrick F. McDermott, Shaohua Zhao, David G. White, Ian Paulsen, and Jianghong Meng
Antimicrob. Agents Chemother. February 2007 51: 535-542; published ahead of print October 16, 2006, doi:10.1128/AAC.00600-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Vancomycin-Intermediate Staphylococcus aureus Strains Have Impaired Acetate Catabolism: Implications for Polysaccharide Intercellular Adhesin Synthesis and Autolysis
Jennifer L. Nelson, Kelly C. Rice, Sean R. Slater, Paige M. Fox, Gordon L. Archer, Kenneth W. Bayles, Paul D. Fey, Barry N. Kreiswirth, and Greg A. Somerville
Antimicrob. Agents Chemother. February 2007 51: 616-622; published ahead of print November 27, 2006, doi:10.1128/AAC.01057-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Ambler Class A ß-Lactamase LAP-1 and Its Association with the Plasmid-Mediated Quinolone Resistance Determinant QnrS1
Laurent Poirel, Vincent Cattoir, Ana Soares, Claude-James Soussy, and Patrice Nordmann
Antimicrob. Agents Chemother. February 2007 51: 631-637; published ahead of print November 20, 2006, doi:10.1128/AAC.01082-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Macrolide Resistance Module Carried by the IncP-1ß Resistance Plasmid pRSB111, Isolated from a Wastewater Treatment Plant
Rafael Szczepanowski, Irene Krahn, Nadine Bohn, Alfred Pühler, and Andreas Schlüter
Antimicrob. Agents Chemother. February 2007 51: 673-678; published ahead of print November 13, 2006, doi:10.1128/AAC.00802-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative DNA Analysis of Two vanA Plasmids from Enterococcus faecium Strains Isolated from Poultry and a Poultry Farmer in Norway
H. Sletvold, P. J. Johnsen, G. S. Simonsen, B. Aasnæs, A. Sundsfjord, and K. M. Nielsen
Antimicrob. Agents Chemother. February 2007 51: 736-739; published ahead of print November 20, 2006, doi:10.1128/AAC.00557-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated KPC-2 in a Klebsiella pneumoniae Isolate from China
Ze-Qing Wei, Xiao-Xing Du, Yun-Song Yu, Ping Shen, Ya-Gang Chen, and Lan-Juan Li
Antimicrob. Agents Chemother. February 2007 51: 763-765; published ahead of print December 4, 2006, doi:10.1128/AAC.01053-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Caenorhabditis elegans as a Model To Determine Fitness of Antibiotic-Resistant Salmonella enterica Serovar Typhimurium
Wilhelm Paulander, Alexandra Pennhag, Dan I. Andersson, and Sophie Maisnier-Patin
Antimicrob. Agents Chemother. February 2007 51: 766-769; published ahead of print November 20, 2006, doi:10.1128/AAC.00615-06
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Multistep Resistance Selection and Postantibiotic-Effect Studies of the Antipneumococcal Activity of LBM415 Compared to Other Agents
Klaudia Kosowska-Shick, Kim L. Credito, Glenn A. Pankuch, Bonifacio DeWasse, Pamela McGhee, and Peter C. Appelbaum
Antimicrob. Agents Chemother. February 2007 51: 770-773; published ahead of print November 20, 2006, doi:10.1128/AAC.01150-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Overexpression and Initial Characterization of the Chromosomal Aminoglycoside 3'-O-Phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa
Mariana Hainrichson, Orit Yaniv, Marina Cherniavsky, Igor Nudelman, Dalia Shallom-Shezifi, Sima Yaron, and Timor Baasov
Antimicrob. Agents Chemother. February 2007 51: 774-776; published ahead of print November 6, 2006, doi:10.1128/AAC.01034-06
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

First Characterization of Fluoroquinolone Resistance in Streptococcus suis
Jose Antonio Escudero, Alvaro San Millan, Ana Catalan, Adela G. de la Campa, Estefania Rivero, Gema Lopez, Lucas Dominguez, Miguel Angel Moreno, and Bruno Gonzalez-Zorn
Antimicrob. Agents Chemother. February 2007 51: 777-782; published ahead of print November 20, 2006, doi:10.1128/AAC.00972-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence and Dissemination of Enterobacteriaceae Isolates Producing CTX-M-1-Like Enzymes in Spain Are Associated with IncFII (CTX-M-15) and Broad-Host-Range (CTX-M-1, -3, and -32) Plasmids
Ângela Novais, Rafael Cantón, Raquel Moreira, Luísa Peixe, Fernando Baquero, and Teresa M. Coque
Antimicrob. Agents Chemother. February 2007 51: 796-799; published ahead of print December 4, 2006, doi:10.1128/AAC.01070-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Clinical Prediction Tool To Identify Patients with Pseudomonas aeruginosa Respiratory Tract Infections at Greatest Risk for Multidrug Resistance
Thomas P. Lodise, Christopher D. Miller, Jeffrey Graves, Jon P. Furuno, Jessina C. McGregor, Ben Lomaestro, Eileen Graffunder, and Louise-Anne McNutt
Antimicrob. Agents Chemother. February 2007 51: 417-422; published ahead of print December 11, 2006, doi:10.1128/AAC.00851-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Treatment and Outcomes of Infections by Methicillin-Resistant Staphylococcus aureus at an Ambulatory Clinic
John D. Szumowski, Daniel E. Cohen, Fumihide Kanaya, and Kenneth H. Mayer
Antimicrob. Agents Chemother. February 2007 51: 423-428; published ahead of print November 20, 2006, doi:10.1128/AAC.01244-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Leishmania donovani Polyamine Biosynthetic Enzyme Overproducers as Tools To Investigate the Mode of Action of Cytotoxic Polyamine Analogs
Sigrid C. Roberts, Yuqui Jiang, Judith Gasteier, Benjamin Frydman, Laurence J. Marton, Olle Heby, and Buddy Ullman
Antimicrob. Agents Chemother. February 2007 51: 438-445; published ahead of print November 20, 2006, doi:10.1128/AAC.01193-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Growth Phase-Dependent Effect of Clindamycin on Production of Exoproteins by Streptococcus pyogenes
Jun Sawai, Tadao Hasegawa, Takuya Kamimura, Akira Okamoto, Daisuke Ohmori, Nobuyuki Nosaka, Keiko Yamada, Keizo Torii, and Michio Ohta
Antimicrob. Agents Chemother. February 2007 51: 461-467; published ahead of print November 13, 2006, doi:10.1128/AAC.00539-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cytotoxic Effect of Curcumin on Malaria Parasite Plasmodium falciparum: Inhibition of Histone Acetylation and Generation of Reactive Oxygen Species
Long Cui, Jun Miao, and Liwang Cui
Antimicrob. Agents Chemother. February 2007 51: 488-494; published ahead of print December 4, 2006, doi:10.1128/AAC.01238-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Putative Role of ß-1,3 Glucans in Candida albicans Biofilm Resistance
Jeniel Nett, Leslie Lincoln, Karen Marchillo, Randall Massey, Kathleen Holoyda, Brian Hoff, Michelle VanHandel, and David Andes
Antimicrob. Agents Chemother. February 2007 51: 510-520; published ahead of print November 27, 2006, doi:10.1128/AAC.01056-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antileishmanial Effect of 3-Aminooxy-1-Aminopropane Is Due to Polyamine Depletion
Sushma Singh, Angana Mukherjee, Alex R. Khomutov, Lo Persson, Olle Heby, Mitali Chatterjee, and Rentala Madhubala
Antimicrob. Agents Chemother. February 2007 51: 528-534; published ahead of print November 13, 2006, doi:10.1128/AAC.01055-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hygromycin B Inhibition of Protein Synthesis and Ribosome Biogenesis in Escherichia coli
Susan M. McGaha and W. Scott Champney
Antimicrob. Agents Chemother. February 2007 51: 591-596; published ahead of print October 16, 2006, doi:10.1128/AAC.01116-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Length Effects in Antimicrobial Peptides of the (RW)_n Series
Zhigang Liu, Anna Brady, Anne Young, Brian Rasimick, Kang Chen, Chunhui Zhou, and Neville R. Kallenbach
Antimicrob. Agents Chemother. February 2007 51: 597-603; published ahead of print December 4, 2006, doi:10.1128/AAC.00828-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds
Trudy H. Grossman, Douglas J. Bartels, Steve Mullin, Christian H. Gross, Jonathan D. Parsons, Yusheng Liao, Anne-Laure Grillot, Dean Stamos, Eric R. Olson, Paul S. Charifson, and Nagraj Mani
Antimicrob. Agents Chemother. February 2007 51: 657-666; published ahead of print November 20, 2006, doi:10.1128/AAC.00596-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Antimalarial Action of the Synthetic Trioxolane RBX11160 (OZ277)
Anne-Catrin Uhlemann, Sergio Wittlin, Hugues Matile, Leyla Y. Bustamante, and Sanjeev Krishna
Antimicrob. Agents Chemother. February 2007 51: 667-672; published ahead of print December 4, 2006, doi:10.1128/AAC.01064-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cysteine Protease Inhibitors Block Toxoplasma gondii Microneme Secretion and Cell Invasion
Chin Fen Teo, Xing Wang Zhou, Matthew Bogyo, and Vern B. Carruthers
Antimicrob. Agents Chemother. February 2007 51: 679-688; published ahead of print December 4, 2006, doi:10.1128/AAC.01059-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Plasmodium falciparum Choline Kinase by Hexadecyltrimethylammonium Bromide: a Possible Antimalarial Mechanism
Vinay Choubey, Pallab Maity, Mithu Guha, Sanjay Kumar, Kumkum Srivastava, Sunil Kumar Puri, and Uday Bandyopadhyay
Antimicrob. Agents Chemother. February 2007 51: 696-706; published ahead of print December 4, 2006, doi:10.1128/AAC.00919-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pyrazinoic Acid and Its n-Propyl Ester Inhibit Fatty Acid Synthase Type I in Replicating Tubercle Bacilli
Oren Zimhony, Catherine Vilchèze, Masayoshi Arai, John T. Welch, and William R. Jacobs, Jr.
Antimicrob. Agents Chemother. February 2007 51: 752-754; published ahead of print November 13, 2006, doi:10.1128/AAC.01369-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole
S. Radhika Prathalingham, Shane R. Wilkinson, David Horn, and John M. Kelly
Antimicrob. Agents Chemother. February 2007 51: 755-758; published ahead of print December 4, 2006, doi:10.1128/AAC.01360-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Efficacy of Bacteriophage Therapy against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice
Ryohei Watanabe, Tetsuya Matsumoto, Go Sano, Yoshikazu Ishii, Kazuhiro Tateda, Yoshinobu Sumiyama, Jumpei Uchiyama, Shingo Sakurai, Shigenobu Matsuzaki, Shosuke Imai, and Keizo Yamaguchi
Antimicrob. Agents Chemother. February 2007 51: 446-452; published ahead of print November 20, 2006, doi:10.1128/AAC.00635-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Chios Mastic Gum Extracts and Constituents against Helicobacter pylori
Sotirios Paraschos, Prokopios Magiatis, Sofia Mitakou, Kalliopi Petraki, Antonios Kalliaropoulos, Petros Maragkoudakis, Andreas Mentis, Dionyssios Sgouras, and Alexios-Leandros Skaltsounis
Antimicrob. Agents Chemother. February 2007 51: 551-559; published ahead of print November 20, 2006, doi:10.1128/AAC.00642-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis: Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy
Radha K. Shandil, Ramesh Jayaram, Parvinder Kaur, Sheshagiri Gaonkar, B. L. Suresh, B. N. Mahesh, R. Jayashree, Vrinda Nandi, Sowmya Bharath, and V. Balasubramanian
Antimicrob. Agents Chemother. February 2007 51: 576-582; published ahead of print December 4, 2006, doi:10.1128/AAC.00414-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Curing Mycobacterium ulcerans Infection in Mice with a Combination of Rifampin-Streptomycin or Rifampin-Amikacin
Sébastien Lefrançois, Jérôme Robert, Aurélie Chauffour, Baohong Ji, and Vincent Jarlier
Antimicrob. Agents Chemother. February 2007 51: 645-650; published ahead of print November 13, 2006, doi:10.1128/AAC.00821-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Protection of Mice from Lethal Escherichia coli Infection by Chimeric Human Bactericidal/Permeability-Increasing Protein and Immunoglobulin G1 Fc Gene Delivery
Jindong Chen, Chengyao Li, Yuanzhi Guan, Qingli Kong, Chen Li, Xianghua Guo, Qinghua Chen, Xuefang Jing, Zhe Lv, and Yunqing An
Antimicrob. Agents Chemother. February 2007 51: 724-731; published ahead of print December 4, 2006, doi:10.1128/AAC.00360-06
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Aspirin Antagonism in Isoniazid Treatment of Tuberculosis in Mice
Sean T. Byrne, Steven M. Denkin, and Ying Zhang
Antimicrob. Agents Chemother. February 2007 51: 794-795; published ahead of print December 4, 2006, doi:10.1128/AAC.01145-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Activities of Antimicrobial Peptides and Synergy with Enrofloxacin against Mycoplasma pulmonis
Lina Fassi Fehri, Henri Wróblewski, and Alain Blanchard
Antimicrob. Agents Chemother. February 2007 51: 468-474; published ahead of print November 13, 2006, doi:10.1128/AAC.01030-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Interaction between Phenothiazines and Antimicrobial Agents against Burkholderia pseudomallei
Ying Ying Chan, Yong Mei Ong, and Kim Lee Chua
Antimicrob. Agents Chemother. February 2007 51: 623-630; published ahead of print December 4, 2006, doi:10.1128/AAC.01033-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimalarial Activity of Azithromycin, Artesunate, and Quinine in Combination and Correlation with Clinical Outcome
Harald Noedl, Srivicha Krudsood, Wattana Leowattana, Noppadon Tangpukdee, Wipa Thanachartwet, Sornchai Looareesuwan, Robert Scott Miller, Mark Fukuda, Krisada Jongsakul, Kritsanai Yingyuen, Sabaithip Sriwichai, Colin Ohrt, and Charles Knirsch
Antimicrob. Agents Chemother. February 2007 51: 651-656; published ahead of print November 20, 2006, doi:10.1128/AAC.01023-06
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Tolerance to the Glycopeptides Vancomycin and Teicoplanin in Coagulase-Negative Staphylococci
Ingrid Bourgeois, Martine Pestel-Caron, Jean-Francois Lemeland, Jean-Louis Pons, and Francois Caron
Antimicrob. Agents Chemother. February 2007 51: 740-743; published ahead of print November 20, 2006, doi:10.1128/AAC.00719-06
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Prevalence and Susceptibility Testing of New Species of Pseudallescheria and Scedosporium in a Collection of Clinical Mold Isolates
Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, Araceli Monzón, and Juan L. Rodriguez-Tudela
Antimicrob. Agents Chemother. February 2007 51: 748-751; published ahead of print November 13, 2006, doi:10.1128/AAC.01177-06
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Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In Vitro
Susanne Perkhofer, Helene Lugger, Manfred P. Dierich, and Cornelia Lass-Flörl
Antimicrob. Agents Chemother. February 2007 51: 791-793; published ahead of print November 20, 2006, doi:10.1128/AAC.01024-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Effects of Age, Gender, and Race/Ethnicity on the Pharmacokinetics of Posaconazole in Healthy Volunteers
Angela Sansone-Parsons, Gopal Krishna, Jason Simon, Peter Soni, B. Kantesaria, Jerry Herron, and Randall Stoltz
Antimicrob. Agents Chemother. February 2007 51: 495-502; published ahead of print November 13, 2006, doi:10.1128/AAC.00472-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasma Amprenavir Pharmacokinetics and Tolerability following Administration of 1,400 Milligrams of Fosamprenavir Once Daily in Combination with either 100 or 200 Milligrams of Ritonavir in Healthy Volunteers
Peter J. Ruane, Andrew D. Luber, Mary Beth Wire, Yu Lou, Mark J. Shelton, C. Tracey Lancaster, Keith A. Pappa COL10053 Study Team
Antimicrob. Agents Chemother. February 2007 51: 560-565; published ahead of print November 6, 2006, doi:10.1128/AAC.00560-06
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The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance
Vincent H. Tam, Arnold Louie, Mark R. Deziel, Weiguo Liu, and George L. Drusano
Antimicrob. Agents Chemother. February 2007 51: 744-747; published ahead of print November 20, 2006, doi:10.1128/AAC.00334-06
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Steady-State Pharmacokinetics of Micafungin and Voriconazole after Separate and Concomitant Dosing in Healthy Adults
J. Keirns, T. Sawamoto, M. Holum, D. Buell, W. Wisemandle, and A. Alak
Antimicrob. Agents Chemother. February 2007 51: 787-790; published ahead of print November 20, 2006, doi:10.1128/AAC.00673-06
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Analytical Procedures:

Estimating True Antimalarial Efficacy by Heteroduplex Tracking Assay in Patients with Complex Plasmodium falciparum Infections
Jesse J. Kwiek, Alisa P. Alker, Emily C. Wenink, Marjorie Chaponda, Linda V. Kalilani, and Steven R. Meshnick
Antimicrob. Agents Chemother. February 2007 51: 521-527; published ahead of print November 20, 2006, doi:10.1128/AAC.00902-06
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High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery
Mary Lynn Baniecki, Dyann F. Wirth, and Jon Clardy
Antimicrob. Agents Chemother. February 2007 51: 716-723; published ahead of print November 20, 2006, doi:10.1128/AAC.01144-06
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Letters:

Klebsiella pneumoniae Isolate Producing at Least Eight Different ß-Lactamases, Including AmpC and KPC ß-Lactamases
Ellen Smith Moland, Seong Geun Hong, Kenneth S. Thomson, Davise H. Larone, and Nancy D. Hanson
Antimicrob. Agents Chemother. February 2007 51: 800-801; published ahead of print December 4, 2006, doi:10.1128/AAC.01143-06
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Further Questions Regarding the Role of Mosaic penA Sequences in Conferring Reduced Susceptibility to Ceftriaxone in Neisseria gonorrhoeae
David M. Whiley, E. Athena Limnios, Sanghamitra Ray, Theo P. Sloots, and John W. Tapsall
Antimicrob. Agents Chemother. February 2007 51: 802-803; published ahead of print November 13, 2006, doi:10.1128/AAC.01307-06
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