Contents: April 2007, Volume 51, Issue 4        Guest Commentary        Mechanisms of Resistance        Antiviral Agents        Susceptibility        Analytical Procedures        Experimental Therapeutics        Pharmacology        Mechanisms of Action        Chemistry; Biosynthesis        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Guest Commentary:

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(Genome) Size Matters Steven J. Projan Antimicrob. Agents Chemother. April 2007 51: 1133-1134; published ahead of print February 12, 2007, doi:10.1128/AAC.01370-06 [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Resistance to Glycopeptide Antibiotics in the Teicoplanin Producer Is Mediated by van Gene Homologue Expression Directing the Synthesis of a Modified Cell Wall Peptidoglycan Fabrizio Beltrametti, Arianna Consolandi, Lucia Carrano, Francesca Bagatin, Roberta Rossi, Livia Leoni, Elisabetta Zennaro, Enrico Selva, and Flavia Marinelli Antimicrob. Agents Chemother. April 2007 51: 1135-1141; published ahead of print January 12, 2007, doi:10.1128/AAC.01071-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clonal Diversity and Resistance Mechanisms in Tetracycline-Nonsusceptible Streptococcus pneumoniae Isolates in Poland Radoslaw Izdebski, Ewa Sadowy, Janusz Fiett, Pawel Grzesiowski, Marek Gniadkowski, and Waleria Hryniewicz Antimicrob. Agents Chemother. April 2007 51: 1155-1163; published ahead of print January 8, 2007, doi:10.1128/AAC.01384-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mosaic Structure of p1658/97, a 125-Kilobase Plasmid Harboring an Active Amplicon with the Extended-Spectrum ß-Lactamase Gene blaSHV-5 M. Zienkiewicz, I. Kern-Zdanowicz, M. Golebiewski, J. Zyliñska, P. Mieczkowski, M. Gniadkowski, J. Bardowski, and P. Ceglowski Antimicrob. Agents Chemother. April 2007 51: 1164-1171; published ahead of print January 12, 2007, doi:10.1128/AAC.00772-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Structure and Resistance Genes in Antibiotic-Resistant Bacteria from a Remote Community with Minimal Antibiotic Exposure Lucia Pallecchi, Chiara Lucchetti, Alessandro Bartoloni, Filippo Bartalesi, Antonia Mantella, Herlan Gamboa, Alessandra Carattoli, Franco Paradisi, and Gian Maria Rossolini Antimicrob. Agents Chemother. April 2007 51: 1179-1184; published ahead of print January 12, 2007, doi:10.1128/AAC.01101-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Elements Carrying erm(B) in Streptococcus pyogenes and Association with tet(M) Tetracycline Resistance Gene Andrea Brenciani, Alessandro Bacciaglia, Manuela Vecchi, Luca A. Vitali, Pietro E. Varaldo, and Eleonora Giovanetti Antimicrob. Agents Chemother. April 2007 51: 1209-1216; published ahead of print January 29, 2007, doi:10.1128/AAC.01484-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of Plasmid-Mediated Quinolone Resistance Determinants QnrA, QnrB, and QnrS among Clinical Isolates of Enterobacter cloacae in a Taiwanese Hospital Jiunn-Jong Wu, Wen-Chien Ko, Shu-Huei Tsai, and Jing-Jou Yan Antimicrob. Agents Chemother. April 2007 51: 1223-1227; published ahead of print January 22, 2007, doi:10.1128/AAC.01195-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of Relationship between Purine Biosynthesis and Vancomycin Resistance in Staphylococcus aureus: a Cautionary Tale for Microarray Interpretation Paige M. Fox, Michael W. Climo, and Gordon L. Archer Antimicrob. Agents Chemother. April 2007 51: 1274-1280; published ahead of print January 22, 2007, doi:10.1128/AAC.01060-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Epidemiology of CTX-M-Producing Escherichia coli in the Calgary Health Region: Emergence of CTX-M-15-Producing Isolates Johann D. D. Pitout, Deirdre L. Church, Daniel B. Gregson, Barbara L. Chow, Melissa McCracken, Michael R. Mulvey, and Kevin B. Laupland Antimicrob. Agents Chemother. April 2007 51: 1281-1286; published ahead of print February 5, 2007, doi:10.1128/AAC.01377-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increased Genome Instability in Escherichia coli lon Mutants: Relation to Emergence of Multiple-Antibiotic-Resistant (Mar) Mutants Caused by Insertion Sequence Elements and Large Tandem Genomic Amplifications Hervé Nicoloff, Vincent Perreten, and Stuart B. Levy Antimicrob. Agents Chemother. April 2007 51: 1293-1303; published ahead of print January 12, 2007, doi:10.1128/AAC.01128-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evolution of TEM-Type Enzymes: Biochemical and Genetic Characterization of Two New Complex Mutant TEM Enzymes, TEM-151 and TEM-152, from a Single Patient Frédéric Robin, Julien Delmas, Cédric Schweitzer, Olivier Tournilhac, Olivier Lesens, Catherine Chanal, and Richard Bonnet Antimicrob. Agents Chemother. April 2007 51: 1304-1309; published ahead of print January 12, 2007, doi:10.1128/AAC.01058-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Genetic Stability of Integrons in Clinical Isolates of Shigella spp. of Worldwide Origin Véronique Dubois, Marie-Pierre Parizano, Corinne Arpin, Laure Coulange, Marie-Christine Bezian, and Claudine Quentin Antimicrob. Agents Chemother. April 2007 51: 1333-1340; published ahead of print January 22, 2007, doi:10.1128/AAC.01109-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development and Persistence of Antimicrobial Resistance in Pseudomonas aeruginosa: a Longitudinal Observation in Mechanically Ventilated Patients Anita Reinhardt, Thilo Köhler, Paul Wood, Peter Rohner, Jean-Luc Dumas, Bara Ricou, and Christian van Delden Antimicrob. Agents Chemother. April 2007 51: 1341-1350; published ahead of print January 29, 2007, doi:10.1128/AAC.01278-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chromosome-Encoded Narrow-Spectrum Ambler Class A ß-Lactamase GIL-1 from Citrobacter gillenii Thierry Naas, Daniel Aubert, Ayla Özcan, and Patrice Nordmann Antimicrob. Agents Chemother. April 2007 51: 1365-1372; published ahead of print January 22, 2007, doi:10.1128/AAC.01152-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Genotyping of CTX-M Extended-Spectrum ß-Lactamases by Denaturing High-Performance Liquid Chromatography Li Xu, Jason Evans, Thomas Ling, Kathy Nye, and Peter Hawkey Antimicrob. Agents Chemother. April 2007 51: 1446-1454; published ahead of print January 8, 2007, doi:10.1128/AAC.01088-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

rpoN Gene of Pseudomonas aeruginosa Alters Its Susceptibility to Quinolones and Carbapenems Darija Viducic, Tsuneko Ono, Keiji Murakami, Mikiko Katakami, Heni Susilowati, and Yoichiro Miyake Antimicrob. Agents Chemother. April 2007 51: 1455-1462; published ahead of print January 29, 2007, doi:10.1128/AAC.00348-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Epidemiology of Macrolide and Tetracycline Resistances in Commensal Gemella sp. Isolates Paula Cerdá Zolezzi, Pilar Goñi Cepero, Joaquim Ruiz, Leticia Millán Laplana, Carmen Rubio Calvo, and Rafael Gómez-Lus Antimicrob. Agents Chemother. April 2007 51: 1487-1490; published ahead of print February 5, 2007, doi:10.1128/AAC.01374-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fitness Cost of Staphylococcal Cassette Chromosome mec in Methicillin-Resistant Staphylococcus aureus by Way of Continuous Culture Sui Mae Lee, Miriam Ender, Rajan Adhikari, John M. B. Smith, Brigitte Berger-Bächi, and Gregory M. Cook Antimicrob. Agents Chemother. April 2007 51: 1497-1499; published ahead of print February 5, 2007, doi:10.1128/AAC.01239-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Studies with DQ-113 and Comparison Fluoroquinolones To Determine Propensities To Select Resistance in Gram-Positive Cocci Seong Geun Hong, Ellen Smith Moland, Paul A. Wickman, Jennifer A. Black, Ashfaque Hossain, Nancy D. Hanson, and Kenneth S. Thomson Antimicrob. Agents Chemother. April 2007 51: 1512-1514; published ahead of print January 12, 2007, doi:10.1128/AAC.00959-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Report of Plasmid-Mediated qnrA1 in a Ciprofloxacin-Resistant Escherichia coli Strain in Latin America Mariana Castanheira, Andrea S. Pereira, Adriana G. Nicoletti, Antônio C. C. Pignatari, Afonso L. Barth, and Ana C. Gales Antimicrob. Agents Chemother. April 2007 51: 1527-1529; published ahead of print January 12, 2007, doi:10.1128/AAC.00780-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetics and Expression of the Carbapenem-Hydrolyzing Oxacillinase Gene blaOXA-23 in Acinetobacter baumannii Stéphane Corvec, Laurent Poirel, Thierry Naas, Henri Drugeon, and Patrice Nordmann Antimicrob. Agents Chemother. April 2007 51: 1530-1533; published ahead of print January 12, 2007, doi:10.1128/AAC.01132-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Linezolid-Resistant Clinical Isolates of Mycobacterium tuberculosis Elvira Richter, Sabine Rüsch-Gerdes, and Doris Hillemann Antimicrob. Agents Chemother. April 2007 51: 1534-1536; published ahead of print January 22, 2007, doi:10.1128/AAC.01113-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dissemination of sul3-Containing Elements Linked to Class 1 Integrons with an Unusual 3' Conserved Sequence Region among Salmonella Isolates Patrícia Antunes, Jorge Machado, and Luísa Peixe Antimicrob. Agents Chemother. April 2007 51: 1545-1548; published ahead of print February 5, 2007, doi:10.1128/AAC.01275-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Identification of Pseudomonas aeruginosa Isolates Producing a KPC-Type Carbapenem-Hydrolyzing ß-Lactamase Maria Virginia Villegas, Karen Lolans, Adriana Correa, Juan Nicolas Kattan, Jaime A. Lopez, John P. Quinn and the Colombian Nosocomial Resistance Study Group Antimicrob. Agents Chemother. April 2007 51: 1553-1555; published ahead of print January 29, 2007, doi:10.1128/AAC.01405-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Resistance in Haemophilus influenzae Is Associated with Hypermutability María Pérez-Vázquez, Federico Román, Silvia García-Cobos, and José Campos Antimicrob. Agents Chemother. April 2007 51: 1566-1569; published ahead of print February 5, 2007, doi:10.1128/AAC.01437-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Novel Boronic Acid Transition State Inhibitors To Probe Substrate Affinity in SHV-Type Extended-Spectrum ß-Lactamases Jodi M. Thomson, Fabio Prati, Christopher R. Bethel, and Robert A. Bonomo Antimicrob. Agents Chemother. April 2007 51: 1577-1579; published ahead of print January 12, 2007, doi:10.1128/AAC.01293-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Zidovudine Inhibits Thymidine Phosphorylation in the Isolated Perfused Rat Heart Delia Susan-Resiga, Alice T. Bentley, Matthew D. Lynx, Darcy D. LaClair, and Edward E. McKee Antimicrob. Agents Chemother. April 2007 51: 1142-1149; published ahead of print January 12, 2007, doi:10.1128/AAC.01227-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Pharmacokinetics of Brecanavir, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, following Repeat Administration with and without Ritonavir in Healthy Adult Subjects Y. Sunila Reddy, Susan L. Ford, Maggie T. Anderson, Sharon C. Murray, Judith Ng-Cashin, and Mark A. Johnson Antimicrob. Agents Chemother. April 2007 51: 1202-1208; published ahead of print January 29, 2007, doi:10.1128/AAC.01005-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Second Extracellular Loop of CCR5 Contains the Dominant Epitopes for Highly Potent Anti-Human Immunodeficiency Virus Monoclonal Antibodies Jun Zhang, Eileen Rao, Marianna Dioszegi, Rama Kondru, Andre DeRosier, Eva Chan, Stephan Schwoerer, Nick Cammack, Michael Brandt, Surya Sankuratri, and Changhua Ji Antimicrob. Agents Chemother. April 2007 51: 1386-1397; published ahead of print January 22, 2007, doi:10.1128/AAC.01302-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives Miguel Stevens, Michela Pollicita, Christophe Pannecouque, Erik Verbeken, Oriana Tabarrini, Violetta Cecchetti, Stefano Aquaro, Carlo Federico Perno, Arnaldo Fravolini, Erik De Clercq, Dominique Schols, and Jan Balzarini Antimicrob. Agents Chemother. April 2007 51: 1407-1413; published ahead of print January 22, 2007, doi:10.1128/AAC.01251-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Oseltamivir Therapy in Ferrets Inoculated with Different Clades of H5N1 Influenza Virus Elena A. Govorkova, Natalia A. Ilyushina, David A. Boltz, Alan Douglas, Neziha Yilmaz, and Robert G. Webster Antimicrob. Agents Chemother. April 2007 51: 1414-1424; published ahead of print February 12, 2007, doi:10.1128/AAC.01312-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interpretation of Genotype and Pharmacokinetics for Resistance to Fosamprenavir-Ritonavir-Based Regimens in Antiretroviral-Experienced Patients Isabelle Pellegrin, Dominique Breilh, Gaelle Coureau, Sébastien Boucher, Didier Neau, Patrick Merel, Denis Lacoste, Hervé Fleury, Marie-Claude Saux, Jean-Luc Pellegrin, Estibaliz Lazaro, François Dabis, Rodolphe Thiébaut for the ANRS Co3 Aquitaine Cohort Antimicrob. Agents Chemother. April 2007 51: 1473-1480; published ahead of print February 12, 2007, doi:10.1128/AAC.00481-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Bactericidal Activity and Resistance Development Profiling of Dalbavancin Beth P. Goldstein, Deborah C. Draghi, Daniel J. Sheehan, Patricia Hogan, and Daniel F. Sahm Antimicrob. Agents Chemother. April 2007 51: 1150-1154; published ahead of print January 12, 2007, doi:10.1128/AAC.00620-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of PD 0305970 and PD 0326448, New Bacterial Gyrase/Topoisomerase Inhibitors with Potent Antibacterial Activities versus Multidrug-Resistant Gram-Positive and Fastidious Organism Groups Michael D. Huband, Michael A. Cohen, Margaret Zurack, Debra L. Hanna, Laura A. Skerlos, Mark C. Sulavik, Glenn W. Gibson, Jeffrey W. Gage, Edmund Ellsworth, Michael A. Stier, and Stephen J. Gracheck Antimicrob. Agents Chemother. April 2007 51: 1191-1201; published ahead of print January 29, 2007, doi:10.1128/AAC.01321-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Growth Inhibition of Toxoplasma gondii and Plasmodium falciparum by Nanomolar Concentrations of 1-Hydroxy-2-Dodecyl-4(1H)Quinolone, a High-Affinity Inhibitor of Alternative (Type II) NADH Dehydrogenases Ahmad Saleh, Johannes Friesen, Stefan Baumeister, Uwe Gross, and Wolfgang Bohne Antimicrob. Agents Chemother. April 2007 51: 1217-1222; published ahead of print January 22, 2007, doi:10.1128/AAC.00895-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotypic and Genotypic Characterization of Streptococcus pyogenes Isolates Displaying the MLSB Phenotype of Macrolide Resistance in Spain, 1999 to 2005 Emilio Pérez-Trallero, Milagrosa Montes, Beatriz Orden, Esther Tamayo, José M. García-Arenzana, and José M. Marimón Antimicrob. Agents Chemother. April 2007 51: 1228-1233; published ahead of print January 22, 2007, doi:10.1128/AAC.01054-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens Michael J. Pucci, Jijun Cheng, Steven D. Podos, Christy L. Thoma, Jane A. Thanassi, Douglas D. Buechter, Gohar Mushtaq, Gerald A. Vigliotti, Jr., Barton J. Bradbury, and Milind Deshpande Antimicrob. Agents Chemother. April 2007 51: 1259-1267; published ahead of print January 22, 2007, doi:10.1128/AAC.01315-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activities of Ceragenins against Clinical Isolates of Resistant Staphylococcus aureus Judy N. Chin, Michael J. Rybak, Chrissy M. Cheung, and Paul B. Savage Antimicrob. Agents Chemother. April 2007 51: 1268-1273; published ahead of print January 8, 2007, doi:10.1128/AAC.01325-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Synthetic Antimicrobial Peptides against Streptococcus mutans Jian He, Randal Eckert, Thanh Pharm, Maurice D. Simanian, Chuhong Hu, Daniel K. Yarbrough, Fengxia Qi, Maxwell H. Anderson, and Wenyuan Shi Antimicrob. Agents Chemother. April 2007 51: 1351-1358; published ahead of print February 12, 2007, doi:10.1128/AAC.01270-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis Sang Hyun Cho, Saradee Warit, Baojie Wan, Chang Hwa Hwang, Guido F. Pauli, and Scott G. Franzblau Antimicrob. Agents Chemother. April 2007 51: 1380-1385; published ahead of print January 8, 2007, doi:10.1128/AAC.00055-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Linezolid against 3,251 Strains of Uncommonly Isolated Gram-Positive Organisms: Report from the SENTRY Antimicrobial Surveillance Program Ronald N. Jones, Matthew G. Stilwell, Patricia A. Hogan, and Daniel J. Sheehan Antimicrob. Agents Chemother. April 2007 51: 1491-1493; published ahead of print January 8, 2007, doi:10.1128/AAC.01496-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci Andrea Giacometti, Oscar Cirioni, Alessandra Riva, Wojciech Kamysz, Carmela Silvestri, Piotr Nadolski, Agnese Della Vittoria, Jerzy Lukasiak, and Giorgio Scalise Antimicrob. Agents Chemother. April 2007 51: 1494-1496; published ahead of print January 12, 2007, doi:10.1128/AAC.00666-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Universal In Vitro Antifungal Resistance of Genetic Clades of the Fusarium solani Species Complex Mónica Azor, Josepa Gené, Josep Cano, and Josep Guarro Antimicrob. Agents Chemother. April 2007 51: 1500-1503; published ahead of print January 12, 2007, doi:10.1128/AAC.01618-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Daptomycin Alone and in Combination with Rifampin and Gentamicin against Staphylococcus aureus Assessed by Time-Kill Methodology Kim Credito, Gengrong Lin, and Peter C. Appelbaum Antimicrob. Agents Chemother. April 2007 51: 1504-1507; published ahead of print January 12, 2007, doi:10.1128/AAC.01455-06 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Antistaphylococcal Activity of DX-619 Alone and in Combination with Vancomycin, Teicoplanin, and Linezolid Assessed by Time-Kill Synergy Testing Kim Credito, Genrong Lin, and Peter C. Appelbaum Antimicrob. Agents Chemother. April 2007 51: 1508-1511; published ahead of print January 29, 2007, doi:10.1128/AAC.01517-06 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Species-Specific Differences in the Susceptibilities of Biofilms Formed by Candida Bloodstream Isolates to Echinocandin Antifungals Hyun Woo Choi, Jong Hee Shin, Sook In Jung, Kyung Hwa Park, Duck Cho, Seung Jung Kee, Myung Geun Shin, Soon Pal Suh, and Dong Wook Ryang Antimicrob. Agents Chemother. April 2007 51: 1520-1523; published ahead of print February 5, 2007, doi:10.1128/AAC.01141-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Disk Diffusion and Agar Dilution Methods for Erythromycin and Ciprofloxacin Susceptibility Testing of Campylobacter jejuni subsp. jejuni Christiane Gaudreau, Yves Girouard, Louise Ringuette, and Catherine Tsimiklis Antimicrob. Agents Chemother. April 2007 51: 1524-1526; published ahead of print January 29, 2007, doi:10.1128/AAC.00905-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Metronidazole plus Rifampin Sterilizes Long-Term Dormant Mycobacterium tuberculosis Elisabetta Iona, Federico Giannoni, Manuela Pardini, Lara Brunori, Graziella Orefici, and Lanfranco Fattorini Antimicrob. Agents Chemother. April 2007 51: 1537-1540; published ahead of print January 22, 2007, doi:10.1128/AAC.01468-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination of Tigecycline and N-Acetylcysteine Reduces Biofilm-Embedded Bacteria on Vascular Catheters Saima Aslam, Barbara W. Trautner, Venkat Ramanathan, and Rabih O. Darouiche Antimicrob. Agents Chemother. April 2007 51: 1556-1558; published ahead of print January 12, 2007, doi:10.1128/AAC.00893-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Daptomycin Susceptibility of Unusual Gram-Positive Bacteria: Comparison of Results Obtained by the Etest and the Broth Microdilution Method Yu-Tsung Huang, Chun-Hsing Liao, Lee-Jeng Teng, and Po-Ren Hsueh Antimicrob. Agents Chemother. April 2007 51: 1570-1572; published ahead of print January 12, 2007, doi:10.1128/AAC.01352-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Drug Susceptibility Profile of Pichia anomala Isolates from Patients Presenting with Nosocomial Fungemia Vânia Lúcia Ribeiro da Matta, Márcia de Souza Carvalho Melhem, Arnaldo Lopes Colombo, Maria Luiza Moretti, Laura Rodero, Gisele Madeira Duboc de Almeida, Marilena dos Anjos Martins, Silvia Figueiredo Costa, Maria Beatriz G. Souza Dias, Márcio Nucci, and Anna S. Levin Antimicrob. Agents Chemother. April 2007 51: 1573-1576; published ahead of print January 29, 2007, doi:10.1128/AAC.01038-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Comparison of a SYBR Green I-Based Assay with a Histidine-Rich Protein II Enzyme-Linked Immunosorbent Assay for In Vitro Antimalarial Drug Efficacy Testing and Application to Clinical Isolates David J. Bacon, Christine Latour, Carmen Lucas, Olga Colina, Pascal Ringwald, and Stéphane Picot Antimicrob. Agents Chemother. April 2007 51: 1172-1178; published ahead of print January 12, 2007, doi:10.1128/AAC.01313-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Poly(D,L-Lactide-Coglycolide) Particles Containing Gentamicin: Pharmacokinetics and Pharmacodynamics in Brucella melitensis- Infected Mice M. C. Lecaroz, M. J. Blanco-Prieto, M. A. Campanero, H. Salman, and C. Gamazo Antimicrob. Agents Chemother. April 2007 51: 1185-1190; published ahead of print January 12, 2007, doi:10.1128/AAC.00809-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of DL--Difluoromethylarginine and Polyamine Analogues against Cryptosporidium parvum Infection in a T-Cell Receptor Alpha-Deficient Mouse Model Nigel Yarlett, W. Ray Waters, James A. Harp, Michael J. Wannemuehler, Mary Morada, Josephine Bellcastro, Steve J. Upton, Laurence J. Marton, and Benjamin J. Frydman Antimicrob. Agents Chemother. April 2007 51: 1234-1239; published ahead of print January 22, 2007, doi:10.1128/AAC.01040-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Neonatal Coinfection Model of Coagulase-Negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: Fluconazole Prophylaxis Enhances Survival and Growth Mohan Pammi Venkatesh, Don Pham, Mindy Fein, Lingkun Kong, and Leonard E. Weisman Antimicrob. Agents Chemother. April 2007 51: 1240-1245; published ahead of print January 29, 2007, doi:10.1128/AAC.01298-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Analysis of Amphotericin B Lipid Complex and Liposomal Amphotericin B Kinetics of Lung Accumulation and Fungal Clearance in a Murine Model of Acute Invasive Pulmonary Aspergillosis Russell E. Lewis, Guangling Liao, Jinggou Hou, Georgios Chamilos, Randall A. Prince, and Dimitrios P. Kontoyiannis Antimicrob. Agents Chemother. April 2007 51: 1253-1258; published ahead of print January 29, 2007, doi:10.1128/AAC.01449-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic/Pharmacodynamic Factors Influencing Emergence of Resistance to Linezolid in an In Vitro Model Lauren M. Boak, Jian Li, Craig R. Rayner, and Roger L. Nation Antimicrob. Agents Chemother. April 2007 51: 1287-1292; published ahead of print January 22, 2007, doi:10.1128/AAC.01194-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gamma Interferon Loaded onto Albumin Nanoparticles: In Vitro and In Vivo Activities against Brucella abortus S. Segura, C. Gamazo, J. M. Irache, and S. Espuelas Antimicrob. Agents Chemother. April 2007 51: 1310-1314; published ahead of print January 12, 2007, doi:10.1128/AAC.00890-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Inhibition of Plasmodium falciparum Rosette Formation by Curdlan Sulfate Helen M. Kyriacou, Katie E. Steen, Ahmed Raza, Monica Arman, George Warimwe, Peter C. Bull, Ivan Havlik, and J. Alexandra Rowe Antimicrob. Agents Chemother. April 2007 51: 1321-1326; published ahead of print February 5, 2007, doi:10.1128/AAC.01216-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Anti-Trypanosoma cruzi Activity of Posaconazole in a Murine Model of Acute Chagas' Disease Is Less Dependent on Gamma Interferon than That of Benznidazole Marcela L. Ferraz, Ricardo T. Gazzinelli, Rosana O. Alves, Julio A. Urbina, and Alvaro J. Romanha Antimicrob. Agents Chemother. April 2007 51: 1359-1364; published ahead of print January 12, 2007, doi:10.1128/AAC.01170-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determination of Antibiotic Efficacy against Bacillus anthracis in a Mouse Aerosol Challenge Model Henry S. Heine, Jennifer Bassett, Lynda Miller, Justin M. Hartings, Bruce E. Ivins, M. Louise Pitt, David Fritz, Sarah L. Norris, and W. Russell Byrne Antimicrob. Agents Chemother. April 2007 51: 1373-1379; published ahead of print February 12, 2007, doi:10.1128/AAC.01050-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species Shu-Hua Xiao, Jennifer Keiser, Jacques Chollet, Jürg Utzinger, Yuxiang Dong, Yvette Endriss, Jonathan L. Vennerstrom, and Marcel Tanner Antimicrob. Agents Chemother. April 2007 51: 1440-1445; published ahead of print February 5, 2007, doi:10.1128/AAC.01537-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activities of Meropenem and Ertapenem against Extended-Spectrum-ß-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in a Neutropenic Mouse Thigh Model C. Andrew DeRyke, Mary Anne Banevicius, Hong Wei Fan, and David P. Nicolau Antimicrob. Agents Chemother. April 2007 51: 1481-1486; published ahead of print February 5, 2007, doi:10.1128/AAC.00752-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus Aldona L. Baltch, William J. Ritz, Lawrence H. Bopp, Phyllis B. Michelsen, and Raymond P. Smith Antimicrob. Agents Chemother. April 2007 51: 1559-1562; published ahead of print February 5, 2007, doi:10.1128/AAC.00973-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drug Therapy of Experimental Tuberculosis (TB): Improved Outcome by Combining SQ109, a New Diamine Antibiotic, with Existing TB Drugs Boris V. Nikonenko, Marina Protopopova, Rowena Samala, Leo Einck, and Carol A. Nacy Antimicrob. Agents Chemother. April 2007 51: 1563-1565; published ahead of print January 22, 2007, doi:10.1128/AAC.01326-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Population Pharmacokinetic Model for Gatifloxacin in Pediatric Patients Christopher M. Rubino, Edmund V. Capparelli, John S. Bradley, Jeffrey L. Blumer, Gregory L. Kearns, Michael Reed, Richard F. Jacobs, Brenda Cirincione, and Dennis M. Grasela Antimicrob. Agents Chemother. April 2007 51: 1246-1252; published ahead of print January 12, 2007, doi:10.1128/AAC.00685-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Resistance in Streptococcus pneumoniae: Area Under the Concentration-Time Curve/MIC Ratio and Resistance Development with Gatifloxacin, Gemifloxacin, Levofloxacin, and Moxifloxacin Kerry L. LaPlante, Michael J. Rybak, Brian Tsuji, Thomas P. Lodise, and Glenn W. Kaatz Antimicrob. Agents Chemother. April 2007 51: 1315-1320; published ahead of print February 12, 2007, doi:10.1128/AAC.00646-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Saquinavir, Atazanavir, and Ritonavir in a Twice-Daily Boosted Double-Protease Inhibitor Regimen Nils von Hentig, Axel Müller, Carsten Rottmann, Timo Wolf, Thomas Lutz, Stephan Klauke, Michael Kurowski, Bruno Oertel, Brenda Dauer, Sebastian Harder, and Schlomo Staszewski Antimicrob. Agents Chemother. April 2007 51: 1431-1439; published ahead of print February 12, 2007, doi:10.1128/AAC.00854-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Miltefosine (Hexadecylphosphocholine) Inhibits Cytochrome c Oxidase in Leishmania donovani Promastigotes Juan Román Luque-Ortega and Luis Rivas Antimicrob. Agents Chemother. April 2007 51: 1327-1332; published ahead of print February 5, 2007, doi:10.1128/AAC.01415-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Peptide Hydrophobicity in the Mechanism of Action of -Helical Antimicrobial Peptides Yuxin Chen, Michael T. Guarnieri, Adriana I. Vasil, Michael L. Vasil, Colin T. Mant, and Robert S. Hodges Antimicrob. Agents Chemother. April 2007 51: 1398-1406; published ahead of print December 11, 2006, doi:10.1128/AAC.00925-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Miltefosine Affects Lipid Metabolism in Leishmania donovani Promastigotes M. Rakotomanga, S. Blanc, K. Gaudin, P. Chaminade, and P. M. Loiseau Antimicrob. Agents Chemother. April 2007 51: 1425-1430; published ahead of print January 22, 2007, doi:10.1128/AAC.01123-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes Françoise Benoit-Vical, Joël Lelièvre, Antoine Berry, Caroline Deymier, Odile Dechy-Cabaret, Jérôme Cazelles, Christophe Loup, Anne Robert, Jean-François Magnaval, and Bernard Meunier Antimicrob. Agents Chemother. April 2007 51: 1463-1472; published ahead of print January 22, 2007, doi:10.1128/AAC.00967-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin Oana Dumitrescu, Sandrine Boisset, Cedric Badiou, Michele Bes, Yvonne Benito, Marie-Elisabeth Reverdy, François Vandenesch, Jerome Etienne, and Gerard Lina Antimicrob. Agents Chemother. April 2007 51: 1515-1519; published ahead of print January 22, 2007, doi:10.1128/AAC.01201-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Inhibition of Streptococcus mutans Biofilm Formation on Hydroxyapatite by Subinhibitory Concentrations of Anthraquinones Tom Coenye, Kris Honraet, Petra Rigole, Pol Nadal Jimenez, and Hans J. Nelis Antimicrob. Agents Chemother. April 2007 51: 1541-1544; published ahead of print January 12, 2007, doi:10.1128/AAC.00999-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Heterologous Production of Albicidin: a Promising Approach to Overproducing and Characterizing This Potent Inhibitor of DNA Gyrase Eric Vivien, Delphine Pitorre, Stéphane Cociancich, Isabelle Pieretti, Dean W. Gabriel, Philippe C. Rott, and Monique Royer Antimicrob. Agents Chemother. April 2007 51: 1549-1552; published ahead of print January 12, 2007, doi:10.1128/AAC.01450-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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In Vitro Activity of API-1252, a Novel FabI Inhibitor, against Clinical Isolates of Staphylococcus aureus and Staphylococcus epidermidis James A. Karlowsky, Nancy M. Laing, Trish Baudry, Nachum Kaplan, David Vaughan, Daryl J. Hoban, and George G. Zhanel Antimicrob. Agents Chemother. April 2007 51: 1580-1581; published ahead of print January 12, 2007, doi:10.1128/AAC.01254-06 [Full Text] [PDF] [Reprints and Permissions]

MexAB-OprM- and MexXY-Overproducing Mutants Are Very Prevalent among Clinical Strains of Pseudomonas aeruginosa with Reduced Susceptibility to Ticarcillin Didier Hocquet, Micheline Roussel-Delvallez, Jean-Didier Cavallo, and Patrick Plésiat Antimicrob. Agents Chemother. April 2007 51: 1582-1583; published ahead of print January 12, 2007, doi:10.1128/AAC.01334-06 [Full Text] [PDF] [Reprints and Permissions]

Emergence and Dissemination of BEL-1-Producing Pseudomonas aeruginosa Isolates in Belgium Pierre Bogaerts, Caroline Bauraing, A. Deplano, and Youri Glupczynski Antimicrob. Agents Chemother. April 2007 51: 1584-1585; published ahead of print January 29, 2007, doi:10.1128/AAC.01603-06 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Comparative In Vitro Efficacies and Antimicrobial Durabilities of Novel Antimicrobial Central Venous Catheters Hend Hanna, Paul Bahna, Ruth Reitzel, Tanya Dvorak, Gassan Chaiban, Ray Hachem, and Issam Raad Antimicrob. Agents Chemother. April 2007 51: 1586 [Full Text] [PDF] [Reprints and Permissions]

Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice Matthieu Prot, Laurence Heripret, Nathalie Cardot-Leccia, Christophe Perrin, Myriam Aouadi, Thibaud Lavrut, Rodolphe Garraffo, Pierre Dellamonica, Jacques Durant, Yannick Le Marchand-Brustel, and Bernard Binétruy Antimicrob. Agents Chemother. April 2007 51: 1587 [Full Text] [PDF] [Reprints and Permissions]

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