AAC -- Table of Contents (July 1 2007, 51 [7])

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Contents: July 2007, Volume 51, Issue 7

       Antiviral Agents

       Mechanisms of Action

       Biologic Response Modifiers

       Mechanisms of Resistance

       Pharmacology

       Susceptibility

       Clinical Therapeutics

       Experimental Therapeutics

       Analytical Procedures

       Recent Approvals

       Letters

Other Issues

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Antiviral Agents:

The L80I Substitution in the Reverse Transcriptase Domain of the Hepatitis B Virus Polymerase Is Associated with Lamivudine Resistance and Enhanced Viral Replication In Vitro
Nadia Warner, Stephen Locarnini, Michael Kuiper, Angeline Bartholomeusz, Anna Ayres, Lilly Yuen, and Tim Shaw
Antimicrob. Agents Chemother. July 2007 51: 2285-2292; published ahead of print April 16, 2007, doi:10.1128/AAC.01499-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity
Laura K. White, Jeong-Joong Yoon, Jin K. Lee, Aiming Sun, Yuhong Du, Haian Fu, James P. Snyder, and Richard K. Plemper
Antimicrob. Agents Chemother. July 2007 51: 2293-2303; published ahead of print April 30, 2007, doi:10.1128/AAC.00289-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Heparin-Mimicking Sulfonic Acid Polymers as Multitarget Inhibitors of Human Immunodeficiency Virus Type 1 Tat and gp120 Proteins
Antonella Bugatti, Chiara Urbinati, Cosetta Ravelli, Erik De Clercq, Sandra Liekens, and Marco Rusnati
Antimicrob. Agents Chemother. July 2007 51: 2337-2345; published ahead of print April 23, 2007, doi:10.1128/AAC.01362-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple-Dose Escalation Study of the Safety, Pharmacokinetics, and Biologic Activity of Oral AMD070, a Selective CXCR4 Receptor Inhibitor, in Human Subjects
Nimalie D. Stone, Shelia B. Dunaway, Charles Flexner, Camlin Tierney, Gary B. Calandra, Stephen Becker, Ying-Jun Cao, Ilene P. Wiggins, Jeanne Conley, Ron T. MacFarland, Jeong-Gun Park, Christina Lalama, Sally Snyder, Beatrice Kallungal, Karin L. Klingman, and Craig W. Hendrix
Antimicrob. Agents Chemother. July 2007 51: 2351-2358; published ahead of print April 23, 2007, doi:10.1128/AAC.00013-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Fluorescence Intensity Screening Assay Identifies New Low-Molecular-Weight Inhibitors of the gp41 Coiled-Coil Domain of Human Immunodeficiency Virus Type 1
Lifeng Cai and Miriam Gochin
Antimicrob. Agents Chemother. July 2007 51: 2388-2395; published ahead of print April 23, 2007, doi:10.1128/AAC.00150-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Defining Limits of Treatment with Humanized Neutralizing Monoclonal Antibody for West Nile Virus Neurological Infection in a Hamster Model
John D. Morrey, Venkatraman Siddharthan, Aaron L. Olsen, Hong Wang, Justin G. Julander, Jeffery O. Hall, Hua Li, Jeffrey L. Nordstrom, Scott Koenig, Syd Johnson, and Michael S. Diamond
Antimicrob. Agents Chemother. July 2007 51: 2396-2402; published ahead of print April 23, 2007, doi:10.1128/AAC.00147-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Resistance Selection and In Vivo Efficacy of Morpholino Oligomers against West Nile Virus
Tia S. Deas, Corey J. Bennett, Susan A. Jones, Mark Tilgner, Ping Ren, Melissa J. Behr, David A. Stein, Patrick L. Iversen, Laura D. Kramer, Kristen A. Bernard, and Pei-Yong Shi
Antimicrob. Agents Chemother. July 2007 51: 2470-2482; published ahead of print May 7, 2007, doi:10.1128/AAC.00069-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapamycin Reduces CCR5 Density Levels on CD4 T Cells, and This Effect Results in Potentiation of Enfuvirtide (T-20) against R5 Strains of Human Immunodeficiency Virus Type 1 In Vitro
Alonso Heredia, Bruce Gilliam, Olga Latinovic, Nhut Le, Douty Bamba, Anthony DeVico, Gregory B. Melikyan, Robert C. Gallo, and Robert R. Redfield
Antimicrob. Agents Chemother. July 2007 51: 2489-2496; published ahead of print May 7, 2007, doi:10.1128/AAC.01602-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Strong and Selective Inhibitors of Hepatitis B Virus Replication among Novel N⁴-Hydroxy- and 5-Methyl-ß-L-Deoxycytidine Analogues
E. Matthes, A. Funk, I. Krahn, K. Gaertner, M. von Janta-Lipinski, L. Lin, H. Will, and H. Sirma
Antimicrob. Agents Chemother. July 2007 51: 2523-2530; published ahead of print April 2, 2007, doi:10.1128/AAC.00001-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Absence of a Universal Mechanism of Mitochondrial Toxicity by Nucleoside Analogs
Kaleb C. Lund, LaRae L. Peterson, and Kendall B. Wallace
Antimicrob. Agents Chemother. July 2007 51: 2531-2539; published ahead of print April 30, 2007, doi:10.1128/AAC.00039-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Inhibition of Porcine Endogenous Retrovirus Replication in Human Cells by Acyclic Nucleoside Phosphonates
Minyi Shi, Xin Wang, Erik De Clercq, Sonshin Takao, and Masanori Baba
Antimicrob. Agents Chemother. July 2007 51: 2600-2604; published ahead of print April 30, 2007, doi:10.1128/AAC.00212-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters
Gadi Borkow, Robert W. Sidwell, Donald F. Smee, Dale L. Barnard, John D. Morrey, Humberto H. Lara-Villegas, Yonat Shemer-Avni, and Jeffrey Gabbay
Antimicrob. Agents Chemother. July 2007 51: 2605-2607; published ahead of print April 30, 2007, doi:10.1128/AAC.00125-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Activity of the Immune Modulator HE2000 on the Incidence of Tuberculosis and Other Opportunistic Infections in AIDS Patients
Dwight R. Stickney, Zoja Noveljic, Armando Garsd, Daniel A. Destiche, and James M. Frincke
Antimicrob. Agents Chemother. July 2007 51: 2639-2641; published ahead of print April 30, 2007, doi:10.1128/AAC.01446-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sultam Thiourea Inhibition of West Nile Virus
Eric Barklis, Amelia Still, Mohammad I. Sabri, Alec J. Hirsch, Janko Nikolich-Zugich, James Brien, Tenzin Choesang Dhenub, Isabel Scholz, and Ayna Alfadhli
Antimicrob. Agents Chemother. July 2007 51: 2642-2645; published ahead of print April 23, 2007, doi:10.1128/AAC.00007-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Transcriptional Response of Candida parapsilosis following Exposure to Farnesol
Tristan Rossignol, Mary E. Logue, Kieran Reynolds, Muriel Grenon, Noel F. Lowndes, and Geraldine Butler
Antimicrob. Agents Chemother. July 2007 51: 2304-2312; published ahead of print May 7, 2007, doi:10.1128/AAC.01438-06
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Amiodarone and Bepridil Inhibit Anthrax Toxin Entry into Host Cells
Ana M. Sanchez, Diane Thomas, Eugene J. Gillespie, Robert Damoiseaux, Joseph Rogers, Jonathan P. Saxe, Jing Huang, Marianne Manchester, and Kenneth A. Bradley
Antimicrob. Agents Chemother. July 2007 51: 2403-2411; published ahead of print May 7, 2007, doi:10.1128/AAC.01184-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Modular Structure of Microcin H47 and Colicin V
María F. Azpiroz and Magela Laviña
Antimicrob. Agents Chemother. July 2007 51: 2412-2419; published ahead of print April 23, 2007, doi:10.1128/AAC.01606-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Isolated Mycobacterium tuberculosis Fatty Acid Synthase I by Pyrazinamide Analogs
Silvana C. Ngo, Oren Zimhony, Woo Jin Chung, Halimah Sayahi, William R. Jacobs, Jr., and John T. Welch
Antimicrob. Agents Chemother. July 2007 51: 2430-2435; published ahead of print May 7, 2007, doi:10.1128/AAC.01458-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus
Jijun Cheng, Jane A. Thanassi, Christy L. Thoma, Barton J. Bradbury, Milind Deshpande, and Michael J. Pucci
Antimicrob. Agents Chemother. July 2007 51: 2445-2453; published ahead of print May 14, 2007, doi:10.1128/AAC.00158-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mass Spectrometry-Based Systems Approach for Identification of Inhibitors of Plasmodium falciparum Fatty Acid Synthase
Shilpi Sharma, Shailendra Kumar Sharma, Rahul Modak, Krishanpal Karmodiya, Namita Surolia, and Avadhesha Surolia
Antimicrob. Agents Chemother. July 2007 51: 2552-2558; published ahead of print May 7, 2007, doi:10.1128/AAC.00124-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Binding of Ceftobiprole and Comparators to the Penicillin-Binding Proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
Todd A. Davies, Malcolm G. P. Page, Wenchi Shang, Ted Andrew, Malgosia Kania, and Karen Bush
Antimicrob. Agents Chemother. July 2007 51: 2621-2624; published ahead of print April 30, 2007, doi:10.1128/AAC.00029-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biologic Response Modifiers:

AM3 Modulates Dendritic Cell Pathogen Recognition Capabilities by Targeting DC-SIGN
Diego Serrano-Gómez, Rocío T. Martínez-Nuñez, Elena Sierra-Filardi, Nuria Izquierdo, María Colmenares, Jesús Pla, Luis Rivas, Javier Martinez-Picado, Jesús Jimenez-Barbero, José Luis Alonso-Lebrero, Salvador González, and Angel L. Corbí
Antimicrob. Agents Chemother. July 2007 51: 2313-2323; published ahead of print April 23, 2007, doi:10.1128/AAC.01289-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

Multicopy bla_OXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii
Alessia Bertini, Laurent Poirel, Sandrine Bernabeu, Daniela Fortini, Laura Villa, Patrice Nordmann, and Alessandra Carattoli
Antimicrob. Agents Chemother. July 2007 51: 2324-2328; published ahead of print April 16, 2007, doi:10.1128/AAC.01502-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of PER-2 and Genetic Environment of bla_PER-2
Pablo Power, José Di Conza, María Margarita Rodríguez, Bárbara Ghiglione, Juan A. Ayala, José María Casellas, Marcela Radice, and Gabriel Gutkind
Antimicrob. Agents Chemother. July 2007 51: 2359-2365; published ahead of print April 16, 2007, doi:10.1128/AAC.01395-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role for Cell Density in Antifungal Drug Resistance in Candida albicans Biofilms
Palani Perumal, Satish Mekala, and W. LaJean Chaffin
Antimicrob. Agents Chemother. July 2007 51: 2454-2463; published ahead of print May 14, 2007, doi:10.1128/AAC.01237-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transferable Resistance to Aminoglycosides by Methylation of G1405 in 16S rRNA and to Hydrophilic Fluoroquinolones by QepA-Mediated Efflux in Escherichia coli
Bruno Périchon, Patrice Courvalin, and Marc Galimand
Antimicrob. Agents Chemother. July 2007 51: 2464-2469; published ahead of print April 30, 2007, doi:10.1128/AAC.00143-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Level Gentamicin Resistance Mediated by a Tn4001-Like Transposon in Seven Nonclonal Hospital Isolates of Streptococcus pasteurianus
Viola C. Y. Chow, Peter M. Hawkey, Edward W. C. Chan, Miu L. Chin, T. K. Au, Danny K. C. Fung, and Raphael C. Y. Chan
Antimicrob. Agents Chemother. July 2007 51: 2508-2513; published ahead of print March 19, 2007, doi:10.1128/AAC.00603-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Phenotypic Characterization of a ß-Lactam-Dependent, Methicillin-Resistant Staphylococcus aureus Strain
Fred Goldstein, Jiri Perutka, Arabela Cuirolo, Konrad Plata, Diego Faccone, Joanne Morris, Aude Sournia, Marie Dominique Kitzis, Aicha Ly, Gordon Archer, and Adriana E. Rosato
Antimicrob. Agents Chemother. July 2007 51: 2514-2522; published ahead of print April 30, 2007, doi:10.1128/AAC.00040-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ampicillin-Resistant Non-ß-Lactamase-Producing Haemophilus influenzae in Spain: Recent Emergence of Clonal Isolates with Increased Resistance to Cefotaxime and Cefixime
Silvia García-Cobos, José Campos, Edurne Lázaro, Federico Román, Emilia Cercenado, César García-Rey, María Pérez-Vázquez, Jesús Oteo, and Francisco de Abajo
Antimicrob. Agents Chemother. July 2007 51: 2564-2573; published ahead of print April 30, 2007, doi:10.1128/AAC.00354-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

gyrA and parC Mutations and Associated Quinolone Resistance in Vibrio anguillarum Serotype O2b Strains Isolated from Farmed Atlantic Cod (Gadus morhua) in Norway
D. J. Colquhoun, L. Aarflot, and C. F. Melvold
Antimicrob. Agents Chemother. July 2007 51: 2597-2599; published ahead of print May 14, 2007, doi:10.1128/AAC.00315-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of an Integron Carrying bla_IMP-1 and a New Aminoglycoside Resistance Gene, aac(6')-31, and Its Dissemination among Genetically Unrelated Clinical Isolates in a Brazilian Hospital
Rodrigo E. Mendes, Mariana Castanheira, Mark A. Toleman, Helio S. Sader, Ronald N. Jones, and Timothy R. Walsh
Antimicrob. Agents Chemother. July 2007 51: 2611-2614; published ahead of print April 30, 2007, doi:10.1128/AAC.00838-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association between embB Codon 306 Mutations and Drug Resistance in Mycobacterium tuberculosis
Xin Shen, Guo-miao Shen, Jie Wu, Xiao-hong Gui, Xia Li, Jian Mei, Kathryn DeRiemer, and Qian Gao
Antimicrob. Agents Chemother. July 2007 51: 2618-2620; published ahead of print April 16, 2007, doi:10.1128/AAC.01516-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea
Jeong Hwan Shin, Hee Jung Jung, Hye Ran Kim, Joseph Jeong, Seok Hoon Jeong, Sunjoo Kim, Eun Yup Lee, Jeong Nyeo Lee, and Chulhun Ludgerus Chang
Antimicrob. Agents Chemother. July 2007 51: 2625-2627; published ahead of print May 14, 2007, doi:10.1128/AAC.00107-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

bla_VIM-2-Harboring Integrons Isolated in India, Russia, and the United States Arise from an Ancestral Class 1 Integron Predating the Formation of the 3' Conserved Sequence
Mark A. Toleman, Hemalatha Vinodh, Uma Sekar, Vijaylakshmi Kamat, and Timothy R. Walsh
Antimicrob. Agents Chemother. July 2007 51: 2636-2638; published ahead of print April 16, 2007, doi:10.1128/AAC.01043-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Isoniazid Bactericidal Activity and Resistance Emergence: Integrating Pharmacodynamics and Pharmacogenomics To Predict Efficacy in Different Ethnic Populations
Tawanda Gumbo, Arnold Louie, Weiguo Liu, David Brown, Paul G. Ambrose, Sujata M. Bhavnani, and George L. Drusano
Antimicrob. Agents Chemother. July 2007 51: 2329-2336; published ahead of print April 16, 2007, doi:10.1128/AAC.00185-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Probability of Target Attainment for Ceftobiprole as Derived from a Population Pharmacokinetic Analysis of 150 Subjects
Thomas P. Lodise, Jr., Rienk Pypstra, James B. Kahn, Bindu P. Murthy, Hui C. Kimko, Karen Bush, Gary J. Noel, and George L. Drusano
Antimicrob. Agents Chemother. July 2007 51: 2378-2387; published ahead of print March 26, 2007, doi:10.1128/AAC.01181-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of the Anti-Human Immunodeficiency Virus Agent 1-(ß-D-Dioxolane)Thymine in Rhesus Monkeys
Ghazia Asif, Selwyn J. Hurwitz, Aleksandr Obikhod, David Delinsky, Janarthanan Narayanasamy, Chung K. Chu, Harold M. McClure, and Raymond F. Schinazi
Antimicrob. Agents Chemother. July 2007 51: 2424-2429; published ahead of print May 7, 2007, doi:10.1128/AAC.01498-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Steady-State Disposition of the Nonpeptidic Protease Inhibitor Tipranavir when Coadministered with Ritonavir
Linzhi Chen, John P. Sabo, Elsy Philip, Yanping Mao, Stephen H. Norris, Thomas R. MacGregor, Jan M. Wruck, Sandra Garfinkel, Mark Castles, Amy Brinkman, and Hernan Valdez
Antimicrob. Agents Chemother. July 2007 51: 2436-2444; published ahead of print May 7, 2007, doi:10.1128/AAC.01115-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis
Valter F. de Andrade-Neto, Tito da Silva, Lucia M. Xavier Lopes, Virgílio E. do Rosário, Fernando de Pilla Varotti, and Antoniana U. Krettli
Antimicrob. Agents Chemother. July 2007 51: 2346-2350; published ahead of print April 16, 2007, doi:10.1128/AAC.01344-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Sporothrix schenckii to Six Antifungal Agents Determined Using Three Different Methods
Eidi Alvarado-Ramírez and Josep M. Torres-Rodríguez
Antimicrob. Agents Chemother. July 2007 51: 2420-2423; published ahead of print April 16, 2007, doi:10.1128/AAC.01176-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of 217 Clinical Isolates of Zygomycetes to Conventional and New Antifungal Agents
Nikolaos G. Almyroudis, Deanna A. Sutton, Annette W. Fothergill, Michael G. Rinaldi, and Shimon Kusne
Antimicrob. Agents Chemother. July 2007 51: 2587-2590; published ahead of print April 23, 2007, doi:10.1128/AAC.00452-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of CG400549, a Novel FabI Inhibitor, against Recently Isolated Clinical Staphylococcal Strains in Korea
Jong Hwa Yum, Chang Ki Kim, Dongeun Yong, Kyungwon Lee, Yunsop Chong, Cheol Min Kim, Jeong Mi Kim, Seonggu Ro, and Joong Myung Cho
Antimicrob. Agents Chemother. July 2007 51: 2591-2593; published ahead of print April 9, 2007, doi:10.1128/AAC.01562-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Enterobacteriaceae Bloodstream Infections: Presence of Integrons, Risk Factors, and Outcome
George L. Daikos, Chris Kosmidis, Panayotis T. Tassios, George Petrikkos, Alexandra Vasilakopoulou, Mina Psychogiou, Ioanna Stefanou, Athina Avlami, and Nikolaos Katsilambros
Antimicrob. Agents Chemother. July 2007 51: 2366-2372; published ahead of print April 23, 2007, doi:10.1128/AAC.00044-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers
J. B. Bulitta, S. B. Duffull, M. Kinzig-Schippers, U. Holzgrabe, U. Stephan, G. L. Drusano, and F. Sörgel
Antimicrob. Agents Chemother. July 2007 51: 2497-2507; published ahead of print May 7, 2007, doi:10.1128/AAC.01477-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Tolerability of a Higher Rifampin Dose versus the Standard Dose in Pulmonary Tuberculosis Patients
Rovina Ruslami, Hanneke M. J. Nijland, Bachti Alisjahbana, Ida Parwati, Reinout van Crevel, and Rob E. Aarnoutse
Antimicrob. Agents Chemother. July 2007 51: 2546-2551; published ahead of print April 23, 2007, doi:10.1128/AAC.01550-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Study of the Effects of Pyridoxine, Rifampin, and Renal Function on Hematological Adverse Events Induced by Linezolid
Alex Soriano, Mar Ortega, Sebastián García, Georgina Peñarroja, Albert Bové, Miguel Marcos, Juan C. Martínez, José A. Martínez, and Josep Mensa
Antimicrob. Agents Chemother. July 2007 51: 2559-2563; published ahead of print April 30, 2007, doi:10.1128/AAC.00247-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Vancomycin In Vitro Bactericidal Activity and Its Relationship to Efficacy in Clearance of Methicillin-Resistant Staphylococcus aureus Bacteremia
Pamela A. Moise, George Sakoulas, Alan Forrest, and Jerome J. Schentag
Antimicrob. Agents Chemother. July 2007 51: 2582-2586; published ahead of print April 23, 2007, doi:10.1128/AAC.00939-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective Randomized Trial of Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High Prevalence of Methicillin-Resistant Staphylococcus aureus
Mary Jo Cenizal, Daniel Skiest, Samuel Luber, Roger Bedimo, Pat Davis, Patrick Fox, Kathleen Delaney, and R. Doug Hardy
Antimicrob. Agents Chemother. July 2007 51: 2628-2630; published ahead of print May 14, 2007, doi:10.1128/AAC.00206-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Efficacy of Telavancin in the Treatment of Experimental Endocarditis Due to Glycopeptide-Intermediate Staphylococcus aureus
José M. Miró, Cristina García-de-la-Mària, Yolanda Armero, Elisa de-Lazzari, Dolors Soy, Asunción Moreno, Ana del Rio, Manel Almela, Carlos A. Mestres, José M. Gatell, María-Teresa Jiménez-de-Anta, Francesc Marco and the Hospital Clínic Experimental Endocarditis Study Group
Antimicrob. Agents Chemother. July 2007 51: 2373-2377; published ahead of print May 7, 2007, doi:10.1128/AAC.01266-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of a Novel Rifamycin Derivative, ABI-0043, against Staphylococcus aureus in an Experimental Model of Foreign-Body Infection
Andrej Trampuz, Christopher K. Murphy, David M. Rothstein, Andreas F. Widmer, Regine Landmann, and Werner Zimmerli
Antimicrob. Agents Chemother. July 2007 51: 2540-2545; published ahead of print May 14, 2007, doi:10.1128/AAC.00120-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of High Mutation Rates on the Mechanisms and Dynamics of In Vitro and In Vivo Resistance Development to Single or Combined Antipseudomonal Agents
V. Plasencia, N. Borrell, M. D. Maciá, B. Moya, J. L. Pérez, and A. Oliver
Antimicrob. Agents Chemother. July 2007 51: 2574-2581; published ahead of print April 30, 2007, doi:10.1128/AAC.00174-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

RNAIII-Inhibiting-Peptide-Loaded Polymethylmethacrylate Prevents In Vivo Staphylococcus aureus Biofilm Formation
Paloma Anguita-Alonso, Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Vittorio Saba, Giorgio Scalise, Milica Sevo, Marina Tuzova, Robin Patel, and Naomi Balaban
Antimicrob. Agents Chemother. July 2007 51: 2594-2596; published ahead of print November 20, 2006, doi:10.1128/AAC.00580-06
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Combined Therapies in a Murine Model of Blastoschizomycosis
Carolina Serena, M. Mar Rodríguez, Marçal Mariné, F. Javier Pastor, and Josep Guarro
Antimicrob. Agents Chemother. July 2007 51: 2608-2610; published ahead of print April 23, 2007, doi:10.1128/AAC.00173-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Fluoroquinolones against Leptospira interrogans in a Hamster Model
Matthew E. Griffith, James E. Moon, Erica N. Johnson, Kyra P. Clark, Joshua S. Hawley, Duane R. Hospenthal, and Clinton K. Murray
Antimicrob. Agents Chemother. July 2007 51: 2615-2617; published ahead of print April 30, 2007, doi:10.1128/AAC.00240-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors
Debra L. Hudson, Abigail N. Layton, Terry R. Field, Alison J. Bowen, Hans Wolf-Watz, Mikael Elofsson, Mark P. Stevens, and Edouard E. Galyov
Antimicrob. Agents Chemother. July 2007 51: 2631-2635; published ahead of print May 14, 2007, doi:10.1128/AAC.01492-06
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Lack of an Effect of Antibiotic Treatment on Prolonged Detection of Chlamydial DNA in Murine Genital Tract Infection
Dawn M. Reeves, Uma Nagarajan, Catherine O'Connell, Charles W. Andrews, Jr., and Toni Darville
Antimicrob. Agents Chemother. July 2007 51: 2646-2648; published ahead of print May 14, 2007, doi:10.1128/AAC.00231-07
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Analytical Procedures:

Statistical Methods for Establishing Quality Control Ranges for Antibacterial Agents in Clinical and Laboratory Standards Institute Susceptibility Testing
John Turnidge and Gerry Bordash
Antimicrob. Agents Chemother. July 2007 51: 2483-2488; published ahead of print April 16, 2007, doi:10.1128/AAC.01457-06
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Recent Approvals:

New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 2006 and New Indications for Previously Approved Agents

Antimicrob. Agents Chemother. July 2007 51: 2649
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Letters:

Vibrio splendidus as the Source of Plasmid-Mediated QnrS-Like Quinolone Resistance Determinants
Vincent Cattoir, Laurent Poirel, Didier Mazel, Claude-James Soussy, and Patrice Nordmann
Antimicrob. Agents Chemother. July 2007 51: 2650-2651; published ahead of print April 23, 2007, doi:10.1128/AAC.00070-07
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Plasmid-Mediated Quinolone Resistance Determinant QnrB4 Identified in France in an Enterobacter cloacae Clinical Isolate Coexpressing a QnrS1 Determinant
Vincent Cattoir, Laurent Poirel, and Patrice Nordmann
Antimicrob. Agents Chemother. July 2007 51: 2652-2653; published ahead of print May 14, 2007, doi:10.1128/AAC.01616-06
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Atorvastatin Is 10-Fold More Active In Vitro than Other Statins against Plasmodium falciparum
Bruno Pradines, Marylin Torrentino-Madamet, Albin Fontaine, Maud Henry, Eric Baret, Joel Mosnier, Sébastien Briolant, Thierry Fusai, and Christophe Rogier
Antimicrob. Agents Chemother. July 2007 51: 2654-2655; published ahead of print May 14, 2007, doi:10.1128/AAC.01330-06
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Relationship of Blood Level and Susceptibility in Voriconazole Treatment of Histoplasmosis
Alison Freifeld, Sandra Arnold, Winnie Ooi, Fabian Chen, Thomas Meyer, L. Joseph Wheat, Melinda Smedema, Ann Lemonte, and Patricia Connolly
Antimicrob. Agents Chemother. July 2007 51: 2656-2657; published ahead of print April 16, 2007, doi:10.1128/AAC.01583-06
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Genetic Environment of ISEcp1 and bla_ACC-1
Sally R. Partridge and Guillaume Arlet
Antimicrob. Agents Chemother. July 2007 51: 2658-2659;
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