AAC -- Table of Contents (August 1 2007, 51 [8])

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Contents: August 2007, Volume 51, Issue 8

       Experimental Therapeutics

       Clinical Therapeutics

       Mechanisms of Resistance

       Antiviral Agents

       Pharmacology

       Susceptibility

       Mechanisms of Action

       Biologic Response Modifiers

       Letters

       Errata

Other Issues

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Experimental Therapeutics:

Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy
Arnold Louie, Mark R. Deziel, Weiguo Liu, and George L. Drusano
Antimicrob. Agents Chemother. August 2007 51: 2661-2667; published ahead of print May 21, 2007, doi:10.1128/AAC.00073-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Fluoroquinolone Treatment on Growth of and Toxin Production by Epidemic and Nonepidemic Clostridium difficile Strains in the Cecal Contents of Mice
Daniel A. Adams, Michelle M. Riggs, and Curtis J. Donskey
Antimicrob. Agents Chemother. August 2007 51: 2674-2678; published ahead of print June 11, 2007, doi:10.1128/AAC.01582-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Affinity, Human Antibody-Like Antibody Fragment (Single-Chain Variable Fragment) Neutralizing the Lethal Factor (LF) of Bacillus anthracis by Inhibiting Protective Antigen-LF Complex Formation
Thibaut Pelat, Michael Hust, Emmanuelle Laffly, Florence Condemine, Chantal Bottex, Dominique Vidal, Marie-Paule Lefranc, Stefan Dübel, and Philippe Thullier
Antimicrob. Agents Chemother. August 2007 51: 2758-2764; published ahead of print May 21, 2007, doi:10.1128/AAC.01528-06
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Experimental Phage Therapy against Staphylococcus aureus in Mice
Rosanna Capparelli, Marianna Parlato, Giorgia Borriello, Paola Salvatore, and Domenico Iannelli
Antimicrob. Agents Chemother. August 2007 51: 2765-2773; published ahead of print May 21, 2007, doi:10.1128/AAC.01513-06
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Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant
Diptesh Sil, Anurupa Shrestha, Matthew R. Kimbrell, Thuan B. Nguyen, Ashok K. Adisechan, Rajalakshmi Balakrishna, Benjamin G. Abbo, Subbalakshmi Malladi, Kelly A. Miller, Shannon Short, Jens R. Cromer, Shravan Arora, Apurba Datta, and Sunil A. David
Antimicrob. Agents Chemother. August 2007 51: 2811-2819; published ahead of print June 4, 2007, doi:10.1128/AAC.00200-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhaled Large Porous Particles of Capreomycin for Treatment of Tuberculosis in a Guinea Pig Model
L. Garcia-Contreras, J. Fiegel, M. J. Telko, K. Elbert, A. Hawi, M. Thomas, J. VerBerkmoes, W. A. Germishuizen, P. B. Fourie, A. J. Hickey, and D. Edwards
Antimicrob. Agents Chemother. August 2007 51: 2830-2836; published ahead of print May 21, 2007, doi:10.1128/AAC.01164-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dexamethasone as Adjuvant Therapy to Moxifloxacin Attenuates Valve Destruction in Experimental Aortic Valve Endocarditis Due to Staphylococcus aureus
Ioannis Skiadas, Angelos Pefanis, Apostolos Papalois, Aspasia Kyroudi, Helen Triantafyllidi, Thomas Tsaganos, and Helen Giamarellou
Antimicrob. Agents Chemother. August 2007 51: 2848-2854; published ahead of print June 11, 2007, doi:10.1128/AAC.01376-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Radioactivity in Bone and Related Structures following Administration of [¹⁴C]Dalbavancin to New Zealand White Rabbits
Eric G. Solon, James A. Dowell, Jonghui Lee, S. Peter King, and Bharat D. Damle
Antimicrob. Agents Chemother. August 2007 51: 3008-3010; published ahead of print June 4, 2007, doi:10.1128/AAC.00020-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Guinea Pig Model of Cryptococcal Meningitis
William R. Kirkpatrick, Laura K. Najvar, Rosie Bocanegra, Thomas F. Patterson, and John R. Graybill
Antimicrob. Agents Chemother. August 2007 51: 3011-3013; published ahead of print June 11, 2007, doi:10.1128/AAC.00085-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Single-Dose Pharmacokinetics of Intravenous Itraconazole and Hydroxypropyl-ß-Cyclodextrin in Infants, Children, and Adolescents
Susan M. Abdel-Rahman, Richard F. Jacobs, Joseph Massarella, Ralph E. Kauffman, John S. Bradley, Hui C. Kimko, Gregory L. Kearns, Kevin Shalayda, Christopher Curtin, Samuel D. Maldonado, and Jeffrey L. Blumer
Antimicrob. Agents Chemother. August 2007 51: 2668-2673; published ahead of print May 21, 2007, doi:10.1128/AAC.00297-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Morbid Obesity on the Single-Dose Pharmacokinetics of Daptomycin
Manjunath P. Pai, Jeffrey P. Norenberg, Tamara Anderson, Diane W. Goade, Keith A. Rodvold, Robert A. Telepak, and Renee-Claude Mercier
Antimicrob. Agents Chemother. August 2007 51: 2741-2747; published ahead of print June 4, 2007, doi:10.1128/AAC.00059-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Rifampin and Multidrug Resistance Gene Polymorphism on Concentrations of Moxifloxacin
Marc Weiner, William Burman, Chi-Cheng Luo, Charles A. Peloquin, Melissa Engle, Stefan Goldberg, Vipin Agarwal, and Andrew Vernon
Antimicrob. Agents Chemother. August 2007 51: 2861-2866; published ahead of print May 21, 2007, doi:10.1128/AAC.01621-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears
A. H. Diacon, R. F. Patientia, A. Venter, P. D. van Helden, P. J. Smith, H. McIlleron, J. S. Maritz, and P. R. Donald
Antimicrob. Agents Chemother. August 2007 51: 2994-2996; published ahead of print May 21, 2007, doi:10.1128/AAC.01474-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

Interaction of the GraRS Two-Component System with the VraFG ABC Transporter To Support Vancomycin-Intermediate Resistance in Staphylococcus aureus
Michael Meehl, Silvia Herbert, Friedrich Götz, and Ambrose Cheung
Antimicrob. Agents Chemother. August 2007 51: 2679-2689; published ahead of print May 14, 2007, doi:10.1128/AAC.00209-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Resistance in Atypical Pneumococci and Oral Streptococci: Evidence of Horizontal Gene Transfer of Fluoroquinolone Resistance Determinants from Streptococcus pneumoniae
Margaret Ip, Shirley S. L. Chau, Fang Chi, Julian Tang, and Paul K. Chan
Antimicrob. Agents Chemother. August 2007 51: 2690-2700; published ahead of print June 4, 2007, doi:10.1128/AAC.00258-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Rapid Dissemination and Diversity of CTX-M Extended-Spectrum ß-Lactamase Genes in Commensal Escherichia coli Isolates from Healthy Children from Low-Resource Settings in Latin America
Lucia Pallecchi, Alessandro Bartoloni, Costanza Fiorelli, Antonia Mantella, Tiziana Di Maggio, Herlan Gamboa, Eduardo Gotuzzo, Göran Kronvall, Franco Paradisi, and Gian Maria Rossolini
Antimicrob. Agents Chemother. August 2007 51: 2720-2725; published ahead of print June 4, 2007, doi:10.1128/AAC.00026-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Promoter and Transcription Analysis of Penicillin-Binding Protein Genes in Streptococcus gordonii
Marisa Haenni, Philippe Moreillon, and Vladimir Lazarevic
Antimicrob. Agents Chemother. August 2007 51: 2774-2783; published ahead of print May 14, 2007, doi:10.1128/AAC.01127-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Target Gene Sequencing To Characterize the Penicillin G Susceptibility of Neisseria meningitidis
Muhamed-Kheir Taha, Julio A. Vázquez, Eva Hong, Desiree E. Bennett, Sophie Bertrand, Suzana Bukovski, Mary T. Cafferkey, Françoise Carion, Jens Jørgen Christensen, Mathew Diggle, Giles Edwards, Rocío Enríquez, Cecilia Fazio, Matthias Frosch, Sigrid Heuberger, Steen Hoffmann, Keith A. Jolley, Marcin Kadlubowski, Amel Kechrid, Konstantinos Kesanopoulos, Paula Kriz, Lotte Lambertsen, Ileanna Levenet, Martin Musilek, Metka Paragi, Aouatef Saguer, Anna Skoczynska, Paola Stefanelli, Sara Thulin, Georgina Tzanakaki, Magnus Unemo, Ulrich Vogel, and Maria Leticia Zarantonelli
Antimicrob. Agents Chemother. August 2007 51: 2784-2792; published ahead of print May 21, 2007, doi:10.1128/AAC.00412-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differentially Expressed Proteins in Derivatives of Candida albicans Displaying a Stable Histatin 3-Resistant Phenotype
Deirdre H. Fitzgerald-Hughes, David C. Coleman, and Brian C. O’ Connell
Antimicrob. Agents Chemother. August 2007 51: 2793-2800; published ahead of print May 7, 2007, doi:10.1128/AAC.00094-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum ß-Lactamases of the CTX-M Type Now in Switzerland
Marie-Frédérique Lartigue, Catherine Zinsius, Aline Wenger, Jacques Bille, Laurent Poirel, and Patrice Nordmann
Antimicrob. Agents Chemother. August 2007 51: 2855-2860; published ahead of print April 30, 2007, doi:10.1128/AAC.01614-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cytoplasmic-Membrane Anchoring of a Class A ß-Lactamase and Its Capacity in Manifesting Antibiotic Resistance
Maxim Suvorov, Sergei B. Vakulenko, and Shahriar Mobashery
Antimicrob. Agents Chemother. August 2007 51: 2937-2942; published ahead of print May 14, 2007, doi:10.1128/AAC.00011-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Systematic Derivation of Marker Sets for Staphylococcal Cassette Chromosome mec Typing
Alex J. Stephens, Flavia Huygens, and Philip M. Giffard
Antimicrob. Agents Chemother. August 2007 51: 2954-2964; published ahead of print May 21, 2007, doi:10.1128/AAC.01323-06
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Identification and Characterization of a New Metallo-ß-Lactamase, IND-5, from a Clinical Isolate of Chryseobacterium indologenes
Mariagrazia Perilli, Bibiana Caporale, Giuseppe Celenza, Cristina Pellegrini, Jean Denis Docquier, Marilina Mezzatesta, Gian Maria Rossolini, Stefania Stefani, and Gianfranco Amicosante
Antimicrob. Agents Chemother. August 2007 51: 2988-2990; published ahead of print April 30, 2007, doi:10.1128/AAC.00083-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increased Expression of ampC in Pseudomonas aeruginosa Mutants Selected with Ciprofloxacin
Daniel J. Wolter, Amber J. Schmidtke, Nancy D. Hanson, and Philip D. Lister
Antimicrob. Agents Chemother. August 2007 51: 2997-3000; published ahead of print May 21, 2007, doi:10.1128/AAC.00111-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Changes in qnr Prevalence and Fluoroquinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Enterobacter spp. Collected from 1990 to 2005
Jacob Strahilevitz, Dalia Engelstein, Amos Adler, Violeta Temper, Allon E. Moses, Colin Block, and Ari Robicsek
Antimicrob. Agents Chemother. August 2007 51: 3001-3003; published ahead of print May 25, 2007, doi:10.1128/AAC.00256-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequencing and Comparative Genomic Analysis of pK29, a 269-Kilobase Conjugative Plasmid Encoding CMY-8 and CTX-M-3 ß-Lactamases in Klebsiella pneumoniae
Ying-Tsong Chen, Tsai-Ling Lauderdale, Tsai-Lien Liao, Yih-Ru Shiau, Hung-Yu Shu, Keh-Ming Wu, Jing-Jou Yan, Ih-Jen Su, and Shih-Feng Tsai
Antimicrob. Agents Chemother. August 2007 51: 3004-3007; published ahead of print May 25, 2007, doi:10.1128/AAC.00167-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Complex Class 1 Integron Bearing an ISCR1 Element in an Escherichia coli Isolate Carrying the bla_CTX-M-14 Gene
Il Kwon Bae, You-Nae Lee, Wee Gyo Lee, Sang Hee Lee, and Seok Hoon Jeong
Antimicrob. Agents Chemother. August 2007 51: 3017-3019; published ahead of print May 21, 2007, doi:10.1128/AAC.00279-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance-Mediating Plasmodium falciparum pfcrt and pfmdr1 Alleles after Treatment with Artesunate-Amodiaquine in Uganda
Samuel L. Nsobya, Christian Dokomajilar, Moses Joloba, Grant Dorsey, and Philip J. Rosenthal
Antimicrob. Agents Chemother. August 2007 51: 3023-3025; published ahead of print June 11, 2007, doi:10.1128/AAC.00012-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of KPC-2 and KPC-3 in Carbapenem-Resistant Klebsiella pneumoniae Strains in an Israeli Hospital
Azita Leavitt, Shiri Navon-Venezia, Inna Chmelnitsky, Mitchell J. Schwaber, and Yehuda Carmeli
Antimicrob. Agents Chemother. August 2007 51: 3026-3029; published ahead of print June 11, 2007, doi:10.1128/AAC.00299-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes
Adriano C. Coelho, Nadine Messier, Marc Ouellette, and Paulo C. Cotrim
Antimicrob. Agents Chemother. August 2007 51: 3030-3032; published ahead of print April 23, 2007, doi:10.1128/AAC.00404-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Activity against Human Immunodeficiency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine
Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi Kodama, Guangwei Yang, Christopher M. Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S. Anderson, Yung-Chi Cheng, and Hiroaki Mitsuya
Antimicrob. Agents Chemother. August 2007 51: 2701-2708; published ahead of print June 4, 2007, doi:10.1128/AAC.00277-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of the Translocation Status of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on the Efficiency of Excision of Tenofovir
Bruno Marchand, Kirsten L. White, John K. Ly, Nicolas A. Margot, Ruth Wang, Martin McDermott, Michael D. Miller, and Matthias Götte
Antimicrob. Agents Chemother. August 2007 51: 2911-2919; published ahead of print May 21, 2007, doi:10.1128/AAC.00314-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase
Jérôme Deval, Megan H. Powdrill, Claudia M. D'Abramo, Luciano Cellai, and Matthias Götte
Antimicrob. Agents Chemother. August 2007 51: 2920-2928; published ahead of print May 14, 2007, doi:10.1128/AAC.00186-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Lamivudine on the Plasma and Intracellular Pharmacokinetics of Apricitabine, a Novel Nucleoside Reverse Transcriptase Inhibitor, in Healthy Volunteers
T. Holdich, L. A. Shiveley, and J. Sawyer
Antimicrob. Agents Chemother. August 2007 51: 2943-2947; published ahead of print January 22, 2007, doi:10.1128/AAC.01013-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increased Survival after Gemfibrozil Treatment of Severe Mouse Influenza
Alison Budd, Lisa Alleva, Mohammed Alsharifi, Aulikki Koskinen, Victoria Smythe, Arno Müllbacher, Jeff Wood, and Ian Clark
Antimicrob. Agents Chemother. August 2007 51: 2965-2968; published ahead of print June 11, 2007, doi:10.1128/AAC.00219-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection
Amy Thomas, Carl Laxton, Joanne Rodman, Nisha Myangar, Nigel Horscroft, and Tanya Parkinson
Antimicrob. Agents Chemother. August 2007 51: 2969-2978; published ahead of print June 4, 2007, doi:10.1128/AAC.00268-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fosamprenavir plus Ritonavir Increases Plasma Ketoconazole and Ritonavir Exposure, while Amprenavir Exposure Remains Unchanged
Mary B. Wire, Charles H. Ballow, Julie Borland, Mark J. Shelton, Yu Lou, Geoffrey Yuen, Jiang Lin, and Eric W. Lewis
Antimicrob. Agents Chemother. August 2007 51: 2982-2984; published ahead of print May 21, 2007, doi:10.1128/AAC.00008-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pegylated Interferon Alfa-2b Monotherapy and Pegylated Interferon Alfa-2b plus Lamivudine Combination Therapy for Patients with Hepatitis B Virus E Antigen-Negative Chronic Hepatitis B
Sabahattin Kaymakoglu, Dilek Oguz, Gurden Gur, Selim Gurel, Ethem Tankurt, Galip Ersöz, Seren Ozenirler, Cem Kalayci, Sule Poturoglu, Yilmaz Cakaloglu, and Atilla Okten
Antimicrob. Agents Chemother. August 2007 51: 3020-3022; published ahead of print May 21, 2007, doi:10.1128/AAC.00088-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Population Pharmacokinetics of Tafenoquine during Malaria Prophylaxis in Healthy Subjects
Bruce G. Charles, Ann K. Miller, Peter E. Nasveld, Mark G. Reid, Ivor E. Harris, and Michael D. Edstein
Antimicrob. Agents Chemother. August 2007 51: 2709-2715; published ahead of print May 21, 2007, doi:10.1128/AAC.01183-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards Phagocytized Staphylococcus aureus by the P-Glycoprotein (MDR1) Efflux Transporter in Human THP-1 Macrophages and Madin-Darby Canine Kidney Cells
Sandrine Lemaire, Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq, and Paul M. Tulkens
Antimicrob. Agents Chemother. August 2007 51: 2748-2757; published ahead of print June 4, 2007, doi:10.1128/AAC.00090-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of the Antiviral Agent ß-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine in Rhesus Monkeys
Ghazia Asif, Selwyn J. Hurwitz, Junxing Shi, Brenda I. Hernandez-Santiago, and Raymond F. Schinazi
Antimicrob. Agents Chemother. August 2007 51: 2877-2882; published ahead of print June 11, 2007, doi:10.1128/AAC.00193-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics, Safety, and Hydrolysis of Oral Pyrroloquinazolinediamines Administered in Single and Multiple Doses in Rats
Qigui Li, Michael P. Kozar, Todd W. Shearer, Lisa H. Xie, Ai J. Lin, Kirsten S. Smith, Yuanzheng Si, Lalaine Anova, Jing Zhang, Wilbur K. Milhous, and Donald R. Skillman
Antimicrob. Agents Chemother. August 2007 51: 2898-2904; published ahead of print June 11, 2007, doi:10.1128/AAC.00932-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

In Vitro Activities of 15 Antimicrobial Agents against 110 Toxigenic Clostridium difficile Clinical Isolates Collected from 1983 to 2004
David W. Hecht, Minerva A. Galang, Susan P. Sambol, James R. Osmolski, Stuart Johnson, and Dale N. Gerding
Antimicrob. Agents Chemother. August 2007 51: 2716-2719; published ahead of print May 21, 2007, doi:10.1128/AAC.01623-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography
Yanjun Li, M. Hong Nguyen, Hartmut Derendorf, Shaoji Cheng, and Cornelius J. Clancy
Antimicrob. Agents Chemother. August 2007 51: 2985-2987; published ahead of print May 21, 2007, doi:10.1128/AAC.00308-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cross-Resistance to Medical and Agricultural Azole Drugs in Yeasts from the Oropharynx of Human Immunodeficiency Virus Patients and from Environmental Bavarian Vine Grapes
Frank-Michael C. Müller, Andrea Staudigel, Stefanie Salvenmoser, Antje Tredup, Rudolf Miltenberger, and Josef V. Herrmann
Antimicrob. Agents Chemother. August 2007 51: 3014-3016; published ahead of print June 4, 2007, doi:10.1128/AAC.00459-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)
Yuxiang Dong, Darren Creek, Jacques Chollet, Hugues Matile, Susan A. Charman, Sergio Wittlin, James K. Wood, and Jonathan L. Vennerstrom
Antimicrob. Agents Chemother. August 2007 51: 3033-3035; published ahead of print May 7, 2007, doi:10.1128/AAC.00264-07
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Mechanisms of Action:

Deoxyribonucleoside Kinases Activate Nucleoside Antibiotics in Severely Pathogenic Bacteria
Michael P. B. Sandrini, Oonagh Shannon, Anders R. Clausen, Lars Björck, and Jure Piskur
Antimicrob. Agents Chemother. August 2007 51: 2726-2732; published ahead of print May 25, 2007, doi:10.1128/AAC.00081-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Activity of Dispersin B and Cefamandole Nafate in Inhibition of Staphylococcal Biofilm Growth on Polyurethanes
G. Donelli, I. Francolini, D. Romoli, E. Guaglianone, A. Piozzi, C. Ragunath, and J. B. Kaplan
Antimicrob. Agents Chemother. August 2007 51: 2733-2740; published ahead of print June 4, 2007, doi:10.1128/AAC.01249-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes
Amanda M. Mathis, Arlene S. Bridges, Mohamed A. Ismail, Arvind Kumar, Iris Francesconi, Mariappan Anbazhagan, Qiyue Hu, Farial A. Tanious, Tanja Wenzler, Janelle Saulter, W. David Wilson, Reto Brun, David W. Boykin, Richard R. Tidwell, and James Edwin Hall
Antimicrob. Agents Chemother. August 2007 51: 2801-2810; published ahead of print May 21, 2007, doi:10.1128/AAC.00005-07
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Chloramphenicol Is a Substrate for a Novel Nitroreductase Pathway in Haemophilus influenzae
Arnold L. Smith, Alice L. Erwin, Toni Kline, William C. T. Unrath, Kevin Nelson, Allan Weber, and William N. Howald
Antimicrob. Agents Chemother. August 2007 51: 2820-2829; published ahead of print May 25, 2007, doi:10.1128/AAC.00087-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rifaximin Does Not Induce Toxin Production or Phage-Mediated Lysis of Shiga Toxin-Producing Escherichia coli
Theresa J. Ochoa, Jane Chen, Christopher M. Walker, Elsa Gonzales, and Thomas G. Cleary
Antimicrob. Agents Chemother. August 2007 51: 2837-2841; published ahead of print May 25, 2007, doi:10.1128/AAC.01397-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

2-tert-Butyl-8-Quinolinamines Exhibit Potent Blood Schizontocidal Antimalarial Activity via Inhibition of Heme Crystallization
Nguyen Tien Huy, Keisuke Mizunuma, Kirandeep Kaur, Nguyen Thanh Thuy Nhien, Meenakshi Jain, Dinh Thanh Uyen, Shigeharu Harada, Rahul Jain, and Kaeko Kamei
Antimicrob. Agents Chemother. August 2007 51: 2842-2847; published ahead of print June 11, 2007, doi:10.1128/AAC.00288-07
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Salicylidene Acylhydrazides That Affect Type III Protein Secretion in Salmonella enterica Serovar Typhimurium
Aurel Negrea, Eva Bjur, Sofia Eriksson Ygberg, Mikael Elofsson, Hans Wolf-Watz, and Mikael Rhen
Antimicrob. Agents Chemother. August 2007 51: 2867-2876; published ahead of print June 4, 2007, doi:10.1128/AAC.00223-07
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Vegetative Clostridium difficile Survives in Room Air on Moist Surfaces and in Gastric Contents with Reduced Acidity: a Potential Mechanism To Explain the Association between Proton Pump Inhibitors and C. difficile-Associated Diarrhea?
Robin L. P. Jump, Michael J. Pultz, and Curtis J. Donskey
Antimicrob. Agents Chemother. August 2007 51: 2883-2887; published ahead of print June 11, 2007, doi:10.1128/AAC.01443-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of NAD⁺-Dependent DNA Ligase of Mycobacteria as a Potential Target for Antibiotics
Malgorzata Korycka-Machala, Ewelina Rychta, Anna Brzostek, Heather R. Sayer, Anna Rumijowska-Galewicz, Richard P. Bowater, and Jaroslaw Dziadek
Antimicrob. Agents Chemother. August 2007 51: 2888-2897; published ahead of print June 4, 2007, doi:10.1128/AAC.00254-07
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Susceptibility of Cryptococcus neoformans to Photodynamic Inactivation Is Associated with Cell Wall Integrity
Beth Burgwyn Fuchs, George P. Tegos, Michael R. Hamblin, and Eleftherios Mylonakis
Antimicrob. Agents Chemother. August 2007 51: 2929-2936; published ahead of print June 4, 2007, doi:10.1128/AAC.00121-07
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In Vitro Interactions between Apricitabine and Other Deoxycytidine Analogues
R. Bethell, J. De Muys, J. Lippens, A. Richard, B. Hamelin, C. Ren, and P. Collins
Antimicrob. Agents Chemother. August 2007 51: 2948-2953; published ahead of print May 21, 2007, doi:10.1128/AAC.01204-06
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Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus
William J. Steinbach, Robert A. Cramer, Jr., B. Zachary Perfect, Christina Henn, Kirsten Nielsen, Joseph Heitman, and John R. Perfect
Antimicrob. Agents Chemother. August 2007 51: 2979-2981; published ahead of print May 14, 2007, doi:10.1128/AAC.01394-06
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Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)
Marcel Kaiser, Sergio Wittlin, Angela Nehrbass-Stuedli, Yuxiang Dong, Xiaofang Wang, Andrew Hemphill, Hugues Matile, Reto Brun, and Jonathan L. Vennerstrom
Antimicrob. Agents Chemother. August 2007 51: 2991-2993; published ahead of print June 11, 2007, doi:10.1128/AAC.00225-07
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Biologic Response Modifiers:

SB-431542, a Transforming Growth Factor ß Inhibitor, Impairs Trypanosoma cruzi Infection in Cardiomyocytes and Parasite Cycle Completion
Mariana C. Waghabi, Michelle Keramidas, Claudia M. Calvet, Marcos Meuser, Maria de Nazaré C. Soeiro, Leila Mendonça-Lima, Tania C. Araújo-Jorge, Jean-Jacques Feige, and Sabine Bailly
Antimicrob. Agents Chemother. August 2007 51: 2905-2910; published ahead of print May 25, 2007, doi:10.1128/AAC.00022-07
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Letters:

Interdomain Loop Mutation Asp190Cys of the Tetracycline Efflux Transporter TetA(B) Decreases Affinity for Substrate
Frédéric M. Sapunaric and Stuart B. Levy
Antimicrob. Agents Chemother. August 2007 51: 3036-3037; published ahead of print May 21, 2007, doi:10.1128/AAC.00357-07
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First Occurrence of an Escherichia coli Clinical Isolate Producing the VIM-1/VIM-2 Hybrid Metallo-ß-Lactamase VIM-12
Alexandros Ikonomidis, Maria Labrou, Zoe Afkou, Antonios N. Maniatis, Danai Sofianou, Athanassios Tsakris, and Spyros Pournaras
Antimicrob. Agents Chemother. August 2007 51: 3038-3039; published ahead of print May 21, 2007, doi:10.1128/AAC.00374-07
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Extended –10 Promoter in ISAba-1 Upstream of bla_OXA-23 from Acinetobacter baumannii
Heidi Segal, Rachael K. Jacobson, Seike Garny, Colleen M. Bamford, and B. Gay Elisha
Antimicrob. Agents Chemother. August 2007 51: 3040-3041; published ahead of print June 4, 2007, doi:10.1128/AAC.00594-07
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SmaI Typeability and Tetracycline Susceptibility and Resistance in Streptococcus pyogenes Isolates with Efflux-Mediated Erythromycin Resistance
A. Bacciaglia, A. Brenciani, P. E. Varaldo, and E. Giovanetti
Antimicrob. Agents Chemother. August 2007 51: 3042-3043; published ahead of print June 11, 2007, doi:10.1128/AAC.00249-07
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Effects of Imipenem-Cilastatin, Ertapenem, Piperacillin-Tazobactam, and Ceftriaxone Treatments on Persistence of Intestinal Colonization by Extended-Spectrum-ß-Lactamase-Producing Klebsiella pneumoniae Strains in Mice
Michael J. Pultz and Curtis J. Donskey
Antimicrob. Agents Chemother. August 2007 51: 3044-3045; published ahead of print June 11, 2007, doi:10.1128/AAC.00194-07
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Errata:

Horizontal Transfer of bla_CMY-Bearing Plasmids among Clinical Escherichia coli and Klebsiella pneumoniae Isolates and Emergence of Cefepime-Hydrolyzing CMY-19
Jun-ichi Wachino, Hiroshi Kurokawa, Satowa Suzuki, Kunikazu Yamane, Naohiro Shibata, Kouji Kimura, Yasuyoshi Ike, and Yoshichika Arakawa
Antimicrob. Agents Chemother. August 2007 51: 3046
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Multiple-Dose Escalation Study of the Safety, Pharmacokinetics, and Biologic Activity of Oral AMD070, a Selective CXCR4 Receptor Inhibitor, in Human Subjects
Nimalie D. Stone, Shelia B. Dunaway, Charles Flexner, Camlin Tierney, Gary B. Calandra, Stephen Becker, Ying-Jun Cao, Ilene P. Wiggins, Jeanne Conley, Ron T. MacFarland, Jeong-Gun Park, Christina Lalama, Sally Snyder, Beatrice Kallungal, Karin L. Klingman, and Craig W. Hendrix
Antimicrob. Agents Chemother. August 2007 51: 3047
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