AAC -- Table of Contents (September 1 2007, 51 [9])

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Contents: September 2007, Volume 51, Issue 9

       Pharmacology

       Mechanisms of Action

       Antiviral Agents

       Susceptibility

       Mechanisms of Resistance

       Clinical Therapeutics

       Experimental Therapeutics

       Letters

       Errata

Other Issues

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Pharmacology:

Pharmacokinetics of Aztreonam in Healthy Subjects and Patients with Cystic Fibrosis and Evaluation of Dose-Exposure Relationships Using Monte Carlo Simulation
Alexander A. Vinks, Ronald N. van Rossem, Ron A. A. Mathôt, Harry G. M. Heijerman, and Johan W. Mouton
Antimicrob. Agents Chemother. September 2007 51: 3049-3055; published ahead of print June 18, 2007, doi:10.1128/AAC.01522-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Pharmacokinetics of Bevirimat (PA-457), a Novel Inhibitor of Human Immunodeficiency Virus Maturation, in Healthy Volunteers
David E. Martin, Robert Blum, John Wilton, Judy Doto, Hal Galbraith, Gina L. Burgess, Philip C. Smith, and Charles Ballow
Antimicrob. Agents Chemother. September 2007 51: 3063-3066; published ahead of print June 18, 2007, doi:10.1128/AAC.01391-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Concomitantly Administered Rifampin on the Pharmacokinetics and Safety of Atazanavir Administered Twice Daily
Edward P. Acosta, Michelle A. Kendall, John G. Gerber, Beverly Alston-Smith, Susan L. Koletar, Andrew R. Zolopa, Sangeeta Agarwala, Michael Child, Richard Bertz, Lara Hosey, and David W. Haas
Antimicrob. Agents Chemother. September 2007 51: 3104-3110; published ahead of print June 18, 2007, doi:10.1128/AAC.00341-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Single- and Multiple-Dose Oral Clarithromycin in Soft Tissues Determined by Microdialysis
Friederike Traunmüller, Markus Zeitlinger, Petra Zeleny, Markus Müller, and Christian Joukhadar
Antimicrob. Agents Chemother. September 2007 51: 3185-3189; published ahead of print July 2, 2007, doi:10.1128/AAC.00532-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice
Xianbin Tian, Jun Li, Maciej J. Zamek-Gliszczynski, Arlene S. Bridges, Peijin Zhang, Nita J. Patel, Thomas J. Raub, Gary M. Pollack, and Kim L. R. Brouwer
Antimicrob. Agents Chemother. September 2007 51: 3230-3234; published ahead of print June 18, 2007, doi:10.1128/AAC.00082-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Chitosan Malate Inhibits Growth and Exotoxin Production of Toxic Shock Syndrome-Inducing Staphylococcus aureus Strains and Group A Streptococci
Patrick M. Schlievert
Antimicrob. Agents Chemother. September 2007 51: 3056-3062; published ahead of print June 18, 2007, doi:10.1128/AAC.01295-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efflux-Related Resistance to Norfloxacin, Dyes, and Biocides in Bloodstream Isolates of Staphylococcus aureus
Carmen E. DeMarco, Laurel A. Cushing, Emmanuel Frempong-Manso, Susan M. Seo, Tinevimbo A. A. Jaravaza, and Glenn W. Kaatz
Antimicrob. Agents Chemother. September 2007 51: 3235-3239; published ahead of print June 18, 2007, doi:10.1128/AAC.00430-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Human Anti-Pseudomonas aeruginosa Serotype O6ad Immunoglobulin G1 Expressed in Transgenic Tobacco Is Capable of Recruiting Immune System Effector Function In Vitro
Michael D. McLean, Kurt C. Almquist, Yongfing Niu, Rhonda Kimmel, Zengzu Lai, John R. Schreiber, and J. Christopher Hall
Antimicrob. Agents Chemother. September 2007 51: 3322-3328; published ahead of print July 2, 2007, doi:10.1128/AAC.00366-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910
Anne J. Lenaerts, Donald Hoff, Sahar Aly, Stefan Ehlers, Koen Andries, Luis Cantarero, Ian M. Orme, and Randall J. Basaraba
Antimicrob. Agents Chemother. September 2007 51: 3338-3345; published ahead of print May 21, 2007, doi:10.1128/AAC.00276-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells
W. Scott Champney and Ward K. Rodgers
Antimicrob. Agents Chemother. September 2007 51: 3385-3387; published ahead of print June 11, 2007, doi:10.1128/AAC.00475-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant Staphylococcus aureus In Vivo
Mick M. Welling, Carlo P. J. M. Brouwer, Wim van 't Hof, Enno C. I. Veerman, and Arie V. Nieuw Amerongen
Antimicrob. Agents Chemother. September 2007 51: 3416-3419; published ahead of print July 9, 2007, doi:10.1128/AAC.00196-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Predictive Genotypic Algorithm for Virologic Response to Lopinavir-Ritonavir in Protease Inhibitor-Experienced Patients
Martin S. King, Richard Rode, Isabelle Cohen-Codar, Vincent Calvez, Anne-Geneviève Marcelin, George J. Hanna, and Dale J. Kempf
Antimicrob. Agents Chemother. September 2007 51: 3067-3074; published ahead of print June 18, 2007, doi:10.1128/AAC.00388-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 2 with Decreased Susceptibility to Lopinavir
Sherie Masse, Xiaozhi Lu, Tatyana Dekhtyar, Liangjun Lu, Gennadiy Koev, Feng Gao, Hongmei Mo, Dale Kempf, Barry Bernstein, George J. Hanna, and Akhteruzzaman Molla
Antimicrob. Agents Chemother. September 2007 51: 3075-3080; published ahead of print June 18, 2007, doi:10.1128/AAC.00146-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antiviral Activity of the Novel, Tyrosyl-Based Human Immunodeficiency Virus (HIV) Type 1 Protease Inhibitor Brecanavir (GW640385) in Combination with Other Antiretrovirals and against a Panel of Protease Inhibitor-Resistant HIV
Richard Hazen, Robert Harvey, Robert Ferris, Charles Craig, Phillip Yates, Philip Griffin, John Miller, Istvan Kaldor, John Ray, Vincente Samano, Eric Furfine, Andrew Spaltenstein, Michael Hale, Roger Tung, Marty St. Clair, Mary Hanlon, and Lawrence Boone
Antimicrob. Agents Chemother. September 2007 51: 3147-3154; published ahead of print July 9, 2007, doi:10.1128/AAC.00401-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5'-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives
Antoine Frangeul, Karine Barral, Karine Alvarez, and Bruno Canard
Antimicrob. Agents Chemother. September 2007 51: 3162-3167; published ahead of print July 9, 2007, doi:10.1128/AAC.00145-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of T-705 against Arenavirus and Bunyavirus Infections
Brian B. Gowen, Min-Hui Wong, Kie-Hoon Jung, Andrew B. Sanders, Michelle Mendenhall, Kevin W. Bailey, Yousuke Furuta, and Robert W. Sidwell
Antimicrob. Agents Chemother. September 2007 51: 3168-3176; published ahead of print July 2, 2007, doi:10.1128/AAC.00356-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Effect of Orally Administered (–)-ß-D-2-Aminopurine Dioxolane in Woodchucks with Chronic Woodchuck Hepatitis Virus Infection
Stephan Menne, Ghazia Asif, Jannan Narayanasamy, Scott D. Butler, Andrea L. George, Selwyn J. Hurwitz, Raymond F. Schinazi, Chung K. Chu, Paul J. Cote, John L. Gerin, and Bud C. Tennant
Antimicrob. Agents Chemother. September 2007 51: 3177-3184; published ahead of print July 2, 2007, doi:10.1128/AAC.00325-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication
Joanna Chapman, Elizabeth Abbott, Dagmar G. Alber, Robert C. Baxter, Sian K. Bithell, Elisa A. Henderson, Malcolm C. Carter, Phil Chambers, Ann Chubb, G. Stuart Cockerill, Peter L. Collins, Verity C. L. Dowdell, Sally J. Keegan, Richard D. Kelsey, Michael J. Lockyer, Cindy Luongo, Pilar Najarro, Raymond J. Pickles, Mark Simmonds, Debbie Taylor, Stan Tyms, Lara J. Wilson, and Kenneth L. Powell
Antimicrob. Agents Chemother. September 2007 51: 3346-3353; published ahead of print June 18, 2007, doi:10.1128/AAC.00211-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Immunochromatographic Strip Test for Rapid Detection of Nevirapine in Plasma Samples from Human Immunodeficiency Virus-Infected Patients
Tim R. Cressey, Sawitree Nangola, Yardpiroon Tawon, Mookda Pattarawarapan, Marc Lallemant, and Chatchai Tayapiwatana
Antimicrob. Agents Chemother. September 2007 51: 3361-3363; published ahead of print July 2, 2007, doi:10.1128/AAC.00445-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral and Anti-Inflammatory Effects of Rosmarinic Acid in an Experimental Murine Model of Japanese Encephalitis
Vivek Swarup, Joydeep Ghosh, Soumya Ghosh, Amit Saxena, and Anirban Basu
Antimicrob. Agents Chemother. September 2007 51: 3367-3370; published ahead of print June 18, 2007, doi:10.1128/AAC.00041-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Paradoxical Growth Effect of Caspofungin Observed on Biofilms and Planktonic Cells of Five Different Candida Species
Analy S. Melo, Arnaldo L. Colombo, and Beth A. Arthington-Skaggs
Antimicrob. Agents Chemother. September 2007 51: 3081-3088; published ahead of print June 25, 2007, doi:10.1128/AAC.00676-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Different Inhibitors of Bacterial Transcription against Staphylococcus epidermidis Biofilm
Philippe Villain-Guillot, Maxime Gualtieri, Lionel Bastide, and Jean-Paul Leonetti
Antimicrob. Agents Chemother. September 2007 51: 3117-3121; published ahead of print July 2, 2007, doi:10.1128/AAC.00343-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Fungicidal Activities of Amphotericin B and Voriconazole against Aspergillus Species Determined by Microbroth Methodology
Joseph Meletiadis, Charalampos Antachopoulos, Theodouli Stergiopoulou, Spyros Pournaras, Emmanuel Roilides, and Thomas J. Walsh
Antimicrob. Agents Chemother. September 2007 51: 3329-3337; published ahead of print June 18, 2007, doi:10.1128/AAC.00345-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility to Posaconazole of 1,903 Yeast Isolates Recovered in France from 2003 to 2006 and Tested by the Method of the European Committee on Antimicrobial Susceptibility Testing
Olivier Lortholary, Eric Dannaoui, Dorothée Raoux, Damien Hoinard, Annick Datry, André Paugam, Jean-Louis Poirot, Claire Lacroix, Françoise Dromer the YEASTS Group
Antimicrob. Agents Chemother. September 2007 51: 3378-3380; published ahead of print June 18, 2007, doi:10.1128/AAC.00496-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Haemophilus ducreyi Is Resistant to Human Antimicrobial Peptides
Kristy L. B. Mount, Carisa A. Townsend, and Margaret E. Bauer
Antimicrob. Agents Chemother. September 2007 51: 3391-3393; published ahead of print July 9, 2007, doi:10.1128/AAC.00473-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Telavancin against Gram-Positive Clinical Isolates Recently Obtained in Europe
W. T. M. Jansen, A. Verel, J. Verhoef, and D. Milatovic
Antimicrob. Agents Chemother. September 2007 51: 3420-3424; published ahead of print July 2, 2007, doi:10.1128/AAC.00100-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Mycoplasma putrefaciens Field Isolates
N. T. Antunes, M. M. Tavío, P. Mercier, R. D. Ayling, W. Al-Momani, P. Assunção, R. S. Rosales, and J. B. Poveda
Antimicrob. Agents Chemother. September 2007 51: 3452-3454; published ahead of print July 16, 2007, doi:10.1128/AAC.00420-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance:

Interactions of Ceftobiprole with ß-Lactamases from Molecular Classes A to D
Anne Marie Queenan, Wenchi Shang, Malgosia Kania, Malcolm G. P. Page, and Karen Bush
Antimicrob. Agents Chemother. September 2007 51: 3089-3095; published ahead of print June 25, 2007, doi:10.1128/AAC.00218-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of penA Alterations and Subtypes in Neisseria gonorrhoeae Strains from Sydney, Australia, That Are Less Susceptible to Ceftriaxone
David M. Whiley, E. Athena Limnios, Sanghamitra Ray, Theo P. Sloots, and John W. Tapsall
Antimicrob. Agents Chemother. September 2007 51: 3111-3116; published ahead of print June 25, 2007, doi:10.1128/AAC.00306-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Characterization of Heterogeneous Resistance to Imipenem in Invasive Nontypeable Haemophilus influenzae Isolates
Marina Cerquetti, Maria Giufrè, Rita Cardines, and Paola Mastrantonio
Antimicrob. Agents Chemother. September 2007 51: 3155-3161; published ahead of print July 9, 2007, doi:10.1128/AAC.00335-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore-Forming Proteins
Myrielle Dupont, Chloë E. James, Jacqueline Chevalier, and Jean-Marie Pagès
Antimicrob. Agents Chemother. September 2007 51: 3190-3198; published ahead of print July 2, 2007, doi:10.1128/AAC.01481-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Occurrence of Tetracycline Resistance Genes among Escherichia coli Isolates from the Phase 3 Clinical Trials for Tigecycline
Margareta Tuckman, Peter J. Petersen, Anita Y. M. Howe, Mark Orlowski, Stanley Mullen, Karen Chan, Patricia A. Bradford, and C. Hal Jones
Antimicrob. Agents Chemother. September 2007 51: 3205-3211; published ahead of print July 9, 2007, doi:10.1128/AAC.00625-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of the CmeABC Efflux Pump to Macrolide and Tetracycline Resistance in Campylobacter jejuni
Amera Gibreel, Nicole M. Wetsch, and Diane E. Taylor
Antimicrob. Agents Chemother. September 2007 51: 3212-3216; published ahead of print July 2, 2007, doi:10.1128/AAC.01592-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identifying Mutator Phenotypes among Fluoroquinolone-Resistant Strains of Streptococcus pneumoniae Using Fluctuation Analysis
Carolyn V. Gould, Paul D. Sniegowski, Mikhail Shchepetov, Joshua P. Metlay, and Jeffrey N. Weiser
Antimicrob. Agents Chemother. September 2007 51: 3225-3229; published ahead of print July 30, 2007, doi:10.1128/AAC.00336-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain
Laura Calatayud, C. Ardanuy, E. Cercenado, A. Fenoll, E. Bouza, R. Pallares, R. Martín, and J. Liñares
Antimicrob. Agents Chemother. September 2007 51: 3240-3246; published ahead of print July 2, 2007, doi:10.1128/AAC.00157-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cloning, Nucleotide Sequencing, and Analysis of the AcrAB-TolC Efflux Pump of Enterobacter cloacae and Determination of Its Involvement in Antibiotic Resistance in a Clinical Isolate
Astrid Pérez, Delia Canle, Cristina Latasa, Margarita Poza, Alejandro Beceiro, María del Mar Tomás, Ana Fernández, Susana Mallo, Sonia Pérez, Francisca Molina, Rosa Villanueva, Iñigo Lasa, and Germán Bou
Antimicrob. Agents Chemother. September 2007 51: 3247-3253; published ahead of print July 16, 2007, doi:10.1128/AAC.00072-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of a qnr-Like Gene in the Intrinsic Resistance of Enterococcus faecalis to Fluoroquinolones
Stéphanie Arsène and Roland Leclercq
Antimicrob. Agents Chemother. September 2007 51: 3254-3258; published ahead of print July 9, 2007, doi:10.1128/AAC.00274-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Plasmid-Mediated Fluoroquinolone Efflux Pump, QepA, Found in an Escherichia coli Clinical Isolate
Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Kouji Kimura, Naohiro Shibata, Haru Kato, Keigo Shibayama, Toshifumi Konda, and Yoshichika Arakawa
Antimicrob. Agents Chemother. September 2007 51: 3354-3360; published ahead of print June 4, 2007, doi:10.1128/AAC.00339-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol
Christopher C. Miller, Mamta Rawat, Todd Johnson, and Yossef Av-Gay
Antimicrob. Agents Chemother. September 2007 51: 3364-3366; published ahead of print July 16, 2007, doi:10.1128/AAC.00347-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Update to the Multiplex PCR Strategy for Assignment of mec Element Types in Staphylococcus aureus
Catarina Milheiriço, Duarte C. Oliveira, and Hermínia de Lencastre
Antimicrob. Agents Chemother. September 2007 51: 3374-3377; published ahead of print June 18, 2007, doi:10.1128/AAC.00275-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Prevalence of Metallo-ß-Lactamase and 16S rRNA Methylase Coproduction among Imipenem-Resistant Pseudomonas aeruginosa Isolates in Brazil
Yohei Doi, Angela C. R. Ghilardi, Jennifer Adams, Doroti de Oliveira Garcia, and David L. Paterson
Antimicrob. Agents Chemother. September 2007 51: 3388-3390; published ahead of print June 18, 2007, doi:10.1128/AAC.00443-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increasing Ceftriaxone Resistance and Multiple Alterations of Penicillin-Binding Proteins among Penicillin-Resistant Streptococcus pneumoniae Isolates in Taiwan
Cheng-Hsun Chiu, Lin-Hui Su, Yhu-Chering Huang, Jui-Chia Lai, Hsiu-Ling Chen, Tsu-Lan Wu, and Tzou-Yien Lin
Antimicrob. Agents Chemother. September 2007 51: 3404-3406; published ahead of print June 25, 2007, doi:10.1128/AAC.01563-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Large-Scale Surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana
Stephan Ehrhardt, Teunis A. Eggelte, Sarah Kaiser, Lydia Adjei, Gerd D. Burchard, Sylvester D. Anemana, Ulrich Bienzle, and Frank P. Mockenhaupt
Antimicrob. Agents Chemother. September 2007 51: 3407-3409; published ahead of print June 11, 2007, doi:10.1128/AAC.00179-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determination of the Primary Target of a Quinolone Drug and the Effect of Quinolone Resistance-Conferring Mutations by Measuring Quinolone Sensitivity Based on Its Mode of Action
Emily S. Pfeiffer and Hiroshi Hiasa
Antimicrob. Agents Chemother. September 2007 51: 3410-3412; published ahead of print July 2, 2007, doi:10.1128/AAC.00362-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Azithromycin Resistance in Treponema pallidum by Real-Time PCR
Mark W. Pandori, Charmie Gordones, Lina Castro, Joseph Engelman, Mark Siedner, Sheila Lukehart, and Jeffrey Klausner
Antimicrob. Agents Chemother. September 2007 51: 3425-3430; published ahead of print July 9, 2007, doi:10.1128/AAC.00340-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum-ß-Lactamase-Producing Enterobacteriaceae Strains in Various Types of Private Health Care Centers
Corinne Arpin, Laure Coulange, Véronique Dubois, Catherine André, Isabelle Fischer, Sophie Fourmaux, Frédéric Grobost, Jacqueline Jullin, Brigitte Dutilh, Jean-Francois Couture, Patrick Noury, Isabelle Lagrange, Aline Ducastaing, Henri-Pierre Doermann, and Claudine Quentin
Antimicrob. Agents Chemother. September 2007 51: 3440-3444; published ahead of print June 25, 2007, doi:10.1128/AAC.01431-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis
Kathleen Julian, Klaudia Kosowska-Shick, Cynthia Whitener, Martin Roos, Harald Labischinski, Aileen Rubio, Leslie Parent, Lois Ednie, Laura Koeth, Tatiana Bogdanovich, and Peter C. Appelbaum
Antimicrob. Agents Chemother. September 2007 51: 3445-3448; published ahead of print July 9, 2007, doi:10.1128/AAC.00559-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Impact of Transmission Intensity on the Accuracy of Genotyping To Distinguish Recrudescence from New Infection in Antimalarial Clinical Trials
Bryan Greenhouse, Christian Dokomajilar, Alan Hubbard, Philip J. Rosenthal, and Grant Dorsey
Antimicrob. Agents Chemother. September 2007 51: 3096-3103; published ahead of print June 25, 2007, doi:10.1128/AAC.00159-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Therapeutic Effect of Nisin Z on Subclinical Mastitis in Lactating Cows
Junqiang Wu, Songhua Hu, and Liting Cao
Antimicrob. Agents Chemother. September 2007 51: 3131-3135; published ahead of print July 2, 2007, doi:10.1128/AAC.00629-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Doxycycline versus Azithromycin for Treatment of Leptospirosis and Scrub Typhus
Kriangsak Phimda, Siriwan Hoontrakul, Chuanpit Suttinont, Sompong Chareonwat, Kitti Losuwanaluk, Sunee Chueasuwanchai, Wirongrong Chierakul, Duangjai Suwancharoen, Saowaluk Silpasakorn, Watcharee Saisongkorh, Sharon J. Peacock, Nicholas P. J. Day, and Yupin Suputtamongkol
Antimicrob. Agents Chemother. September 2007 51: 3259-3263; published ahead of print July 16, 2007, doi:10.1128/AAC.00508-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association of Saquinavir Plasma Concentrations with Side Effects but Not with Antiretroviral Outcome in Patients Infected with Protease Inhibitor-Susceptible Human Immunodeficiency Virus Type 1
Jörn Lötsch, Sebastian Harder, Martin Stürmer, Hans-Wilhelm Doerr, Gerd Geisslinger, Schlomo Staszewski, and Nils von Hentig
Antimicrob. Agents Chemother. September 2007 51: 3264-3272; published ahead of print June 18, 2007, doi:10.1128/AAC.00036-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intermittent Preventive Treatment in Infants as a Means of Malaria Control: a Randomized, Double-Blind, Placebo-Controlled Trial in Northern Ghana
Frank P. Mockenhaupt, Klaus Reither, Philipp Zanger, Felix Roepcke, Ina Danquah, Eiman Saad, Peter Ziniel, Stephen Y. Dzisi, Marc Frempong, Patrick Agana-Nsiire, Felicia Amoo-Sakyi, Rowland Otchwemah, Jakob P. Cramer, Sylvester D. Anemana, Ekkehart Dietz, and Ulrich Bienzle
Antimicrob. Agents Chemother. September 2007 51: 3273-3281; published ahead of print July 16, 2007, doi:10.1128/AAC.00513-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics at Two Dose Levels and Pharmacodynamic Profiling of Flucloxacillin
Cornelia B. Landersdorfer, Carl M. J. Kirkpatrick, Martina Kinzig-Schippers, Jürgen B. Bulitta, Ulrike Holzgrabe, George L. Drusano, and Fritz Sörgel
Antimicrob. Agents Chemother. September 2007 51: 3290-3297; published ahead of print June 18, 2007, doi:10.1128/AAC.01410-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tetracyclines as an Oral Treatment Option for Patients with Community Onset Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus
Jörg J. Ruhe and Anupama Menon
Antimicrob. Agents Chemother. September 2007 51: 3298-3303; published ahead of print June 18, 2007, doi:10.1128/AAC.00262-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized, Controlled Trial
Samir G. Sakka, Anna K. Glauner, Jürgen B. Bulitta, Martina Kinzig-Schippers, Wolfgang Pfister, George L. Drusano, and Fritz Sörgel
Antimicrob. Agents Chemother. September 2007 51: 3304-3310; published ahead of print July 9, 2007, doi:10.1128/AAC.01318-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of Staphylococcus aureus Isolates from a 2005 Clinical Trial of Uncomplicated Skin and Skin Structure Infections
Ronald N. Jones, Angela M. Nilius, Bolanle K. Akinlade, Lalitagauri M. Deshpande, and Gerard F. Notario
Antimicrob. Agents Chemother. September 2007 51: 3381-3384; published ahead of print June 18, 2007, doi:10.1128/AAC.01588-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Concanavalin A Protects Mice from a Lethal Inoculation of Intragastric Klebsiella pneumoniae and Reduces the Induced Liver Damage
Chih-Feng Kuo, Ya-Hui Wang, Huan-Yao Lei, Chiou-Huey Wang, and Nina Tsao
Antimicrob. Agents Chemother. September 2007 51: 3122-3130; published ahead of print July 2, 2007, doi:10.1128/AAC.01379-06
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Distribution of Suramin, an Antitrypanosomal Drug, across the Blood-Brain and Blood-Cerebrospinal Fluid Interfaces in Wild-Type and P-Glycoprotein Transporter-Deficient Mice
Lisa Sanderson, Adil Khan, and Sarah Thomas
Antimicrob. Agents Chemother. September 2007 51: 3136-3146; published ahead of print June 18, 2007, doi:10.1128/AAC.00372-07
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Effect of Delayed Pulsed-Wave Ultrasound on Local Pharmacokinetics and Pharmacodynamics of Vancomycin-Loaded Acrylic Bone Cement In Vivo
Xun-Zi Cai, Shi-Gui Yan, Hao-Bo Wu, Rong-Xin He, Xue-Song Dai, Hai-Xiang Chen, Rui-Jian Yan, and Xin-Hua Zhao
Antimicrob. Agents Chemother. September 2007 51: 3199-3204; published ahead of print July 9, 2007, doi:10.1128/AAC.01465-06
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Use of a Bioluminescent Pseudomonas aeruginosa Strain within an In Vitro Microbiological System, as a Model of Wound Infection, To Assess the Antimicrobial Efficacy of Wound Dressings by Monitoring Light Production
R. M. S. Thorn, S. M. Nelson, and J. Greenman
Antimicrob. Agents Chemother. September 2007 51: 3217-3224; published ahead of print July 16, 2007, doi:10.1128/AAC.00302-07
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Impact of Dual Infections on Chemotherapeutic Efficacy in BALB/c Mice Infected with Major Genotypes of Trypanosoma cruzi
H. R. Martins, R. Moreira Silva, H. M. S. Valadares, M. J. O. Toledo, V. M. Veloso, D. M. Vitelli-Avelar, C. M. Carneiro, G. L. L. Machado-Coelho, M. T. Bahia, O. A. Martins-Filho, A. M. Macedo, and M. Lana
Antimicrob. Agents Chemother. September 2007 51: 3282-3289; published ahead of print July 16, 2007, doi:10.1128/AAC.01590-06
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Pharmacodynamic Effects of Telavancin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Strains in the Presence of Human Albumin or Serum and in an In Vitro Kinetic Model
Inga Odenholt, Elisabeth Löwdin, and Otto Cars
Antimicrob. Agents Chemother. September 2007 51: 3311-3316; published ahead of print July 9, 2007, doi:10.1128/AAC.01470-06
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In Vivo Efficacy and Pharmacokinetics of Voriconazole in an Animal Model of Dermatophytosis
D. M. Saunte, F. Simmel, N. Frimodt-Moller, L. B. Stolle, E. L. Svejgaard, M. Haedersdal, C. Kloft, and M. C. Arendrup
Antimicrob. Agents Chemother. September 2007 51: 3317-3321; published ahead of print June 18, 2007, doi:10.1128/AAC.01185-06
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Pneumococcal LytA Autolysin, a Potent Therapeutic Agent in Experimental Peritonitis-Sepsis Caused by Highly ß-Lactam-Resistant Streptococcus pneumoniae
Violeta Rodríguez-Cerrato, Pedro García, Lorena Huelves, Ernesto García, Gema del Prado, Matilde Gracia, Carmen Ponte, Rubens López, and Francisco Soriano
Antimicrob. Agents Chemother. September 2007 51: 3371-3373; published ahead of print June 18, 2007, doi:10.1128/AAC.00137-07
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Tick Acquisition of Ehrlichia canis from Dogs Treated with Doxycycline Hyclate
John J. Schaefer, Glen R. Needham, William G. Bremer, Yasuko Rikihisa, S. A. Ewing, and R. W. Stich
Antimicrob. Agents Chemother. September 2007 51: 3394-3396; published ahead of print July 2, 2007, doi:10.1128/AAC.00358-07
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In Vivo Efficacy of Ceftaroline (PPI-0903), a New Broad-Spectrum Cephalosporin, Compared with Linezolid and Vancomycin against Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus in a Rabbit Endocarditis Model
Cédric Jacqueline, Jocelyne Caillon, Virginie Le Mabecque, Anne-Françoise Miègeville, Antoine Hamel, Denis Bugnon, James Yigong Ge, and Gilles Potel
Antimicrob. Agents Chemother. September 2007 51: 3397-3400; published ahead of print June 25, 2007, doi:10.1128/AAC.01242-06
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In Vivo Efficacy of Moxifloxacin Compared with Cloxacillin and Vancomycin in a Staphylococcus aureus Rabbit Arthritis Experimental Model
Olivier Grossi, Jocelyne Caillon, Cedric Arvieux, Cedric Jacqueline, Denis Bugnon, Gilles Potel, and Antoine Hamel
Antimicrob. Agents Chemother. September 2007 51: 3401-3403; published ahead of print June 18, 2007, doi:10.1128/AAC.01520-06
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Activity of Colistin against Heteroresistant Acinetobacter baumannii and Emergence of Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model
Chun-Hong Tan, Jian Li, and Roger L. Nation
Antimicrob. Agents Chemother. September 2007 51: 3413-3415; published ahead of print July 9, 2007, doi:10.1128/AAC.01571-06
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Colistin Methanesulfonate against Multidrug-Resistant Acinetobacter baumannii in an In Vitro Pharmacodynamic Model
Lisa A. Kroeger, Laurie B. Hovde, Isaac F. Mitropoulos, Jeremy Schafer, and John C. Rotschafer
Antimicrob. Agents Chemother. September 2007 51: 3431-3433; published ahead of print June 18, 2007, doi:10.1128/AAC.01433-06
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In Vivo Efficacy of a Novel Oxazolidinone Compound in Two Mouse Models of Infection
Charles J. Gill, George K. Abruzzo, Amy M. Flattery, Andrew S. Misura, Ken Bartizal, and Emily J. Hickey
Antimicrob. Agents Chemother. September 2007 51: 3434-3436; published ahead of print July 2, 2007, doi:10.1128/AAC.01567-06
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In Vivo Activity of a Novel Polymeric Guanidine in Experimental Skin Infection with Methicillin-Resistant Staphylococcus aureus
Christina Kratzer, Selma Tobudic, Karin Macfelda, Wolfgang Graninger, and Apostolos Georgopoulos
Antimicrob. Agents Chemother. September 2007 51: 3437-3439; published ahead of print July 9, 2007, doi:10.1128/AAC.00130-07
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Concentration-Effect Relationship of Ceftazidime Explains Why the Time above the MIC Is 40 Percent for a Static Effect In Vivo
Johan W. Mouton, Nieko Punt, and Alexander A. Vinks
Antimicrob. Agents Chemother. September 2007 51: 3449-3451; published ahead of print June 18, 2007, doi:10.1128/AAC.01586-06
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Letters:

Induction of Voriconazole Metabolism by Rifampin in a Patient with Acute Myeloid Leukemia: Importance of Interdisciplinary Communication To Prevent Treatment Errors with Complex Medications
Marcus J. P. Geist, Gerlinde Egerer, Jürgen Burhenne, Klaus-Dieter Riedel, and Gerd Mikus
Antimicrob. Agents Chemother. September 2007 51: 3455-3456; published ahead of print July 2, 2007, doi:10.1128/AAC.00579-07
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Synergistic Effect of Posaconazole and Caspofungin against Clinical Zygomycetes
María Guembe, Jesús Guinea, Teresa Peláez, Marta Torres-Narbona, and Emilio Bouza
Antimicrob. Agents Chemother. September 2007 51: 3457-3458; published ahead of print June 18, 2007, doi:10.1128/AAC.00595-07
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Altered Pharmacokinetics of Voriconazole in a Patient with Liver Cirrhosis
Stefan Weiler, Heinz Zoller, Ivo Graziadei, Wolfgang Vogel, Rosa Bellmann-Weiler, Michael Joannidis, and Romuald Bellmann
Antimicrob. Agents Chemother. September 2007 51: 3459-3460; published ahead of print July 2, 2007, doi:10.1128/AAC.00791-07
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Antibiotic Resistance Gene Cluster of pAPEC-O1-R
Ruth M. Hall
Antimicrob. Agents Chemother. September 2007 51: 3461-3462; published ahead of print June 25, 2007, doi:10.1128/AAC.00417-07
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Can the Etest Correctly Determine the MICs of ß-Lactam and Cephalosporin Antibiotics for Beta-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae?
Dewan Sakhawat Billal, Muneki Hotomi, and Noboru Yamanaka
Antimicrob. Agents Chemother. September 2007 51: 3463-3464; published ahead of print July 2, 2007, doi:10.1128/AAC.00190-07
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Molecular Epidemiology of Imipenem-Resistant Acinetobacter haemolyticus and Acinetobacter baumannii Isolates Carrying Plasmid-Mediated OXA-40 from a Portuguese Hospital
Sandra Quinteira, Filipa Grosso, Helena Ramos, and Luísa Peixe
Antimicrob. Agents Chemother. September 2007 51: 3465-3466; published ahead of print July 2, 2007, doi:10.1128/AAC.00267-07
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Detection of Gene Cassettes in Tn402-Like Class 1 Integrons
Virginia Post, Gavin D. Recchia, and Ruth M. Hall
Antimicrob. Agents Chemother. September 2007 51: 3467-3468; published ahead of print June 25, 2007, doi:10.1128/AAC.00220-07
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Errata:

Predictors of Mortality in Patients with Bloodstream Infections Caused by Extended-Spectrum-ß-Lactamase-Producing Enterobacteriaceae: Importance of Inadequate Initial Antimicrobial Treatment
Mario Tumbarello, Maurizio Sanguinetti, Eva Montuori, Enrico M. Trecarichi, Brunella Posteraro, Barbara Fiori, Rita Citton, Tiziana D'Inzeo, Giovanni Fadda, Roberto Cauda, and Teresa Spanu
Antimicrob. Agents Chemother. September 2007 51: 3469
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