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Instructions To Authors:

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY: 2008 INSTRUCTIONS TO AUTHORS
Antimicrob. Agents Chemother. 2008 52: 1-23. [Full Text] [PDF] [Reprints and Permissions]  

Minireviews:

Sungmin Kiem and Jerome J. Schentag

Interpretation of Antibiotic Concentration Ratios Measured in Epithelial Lining Fluid
Antimicrob. Agents Chemother. 2008 52: 24-36. [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

Gary J. Noel, Richard S. Strauss, Karen Amsler, Markus Heep, Rienk Pypstra, and Joseph S. Solomkin

Results of a Double-Blind, Randomized Trial of Ceftobiprole Treatment of Complicated Skin and Skin Structure Infections Caused by Gram-Positive Bacteria
Antimicrob. Agents Chemother. 2008 52: 37-44. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sung-Han Kim, Kye-Hyung Kim, Hong-Bin Kim, Nam-Joong Kim, Eui-Chong Kim, Myoung-don Oh, and Kang-Won Choe

Outcome of Vancomycin Treatment in Patients with Methicillin-Susceptible Staphylococcus aureus Bacteremia
Antimicrob. Agents Chemother. 2008 52: 192-197. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

J. A. Passarell, A. K. Meagher, K. Liolios, B. B. Cirincione, S. A. Van Wart, T. Babinchak, E. J. Ellis-Grosse, and P. G. Ambrose

Exposure-Response Analyses of Tigecycline Efficacy in Patients with Complicated Intra-Abdominal Infections
Antimicrob. Agents Chemother. 2008 52: 204-210. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Harin A. Karunajeewa, Kenneth F. Ilett, Ivo Mueller, Peter Siba, Irwin Law, Madhu Page-Sharp, Enmoore Lin, Jovitha Lammey, Kevin T. Batty, and Timothy M. E. Davis

Pharmacokinetics and Efficacy of Piperaquine and Chloroquine in Melanesian Children with Uncomplicated Malaria
Antimicrob. Agents Chemother. 2008 52: 237-243. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Todd A. Davies, Eugene Leibovitz, Gary J. Noel, David F. McNeeley, Karen Bush, and Ron Dagan

Characterization and Dynamics of Middle Ear Fluid and Nasopharyngeal Isolates of Streptococcus pneumoniae from 12 Children Treated with Levofloxacin
Antimicrob. Agents Chemother. 2008 52: 378-381. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Hui-min Neoh, Longzhu Cui, Harumi Yuzawa, Fumihiko Takeuchi, Miki Matsuo, and Keiichi Hiramatsu

Mutated Response Regulator graR Is Responsible for Phenotypic Conversion of Staphylococcus aureus from Heterogeneous Vancomycin-Intermediate Resistance to Vancomycin-Intermediate Resistance
Antimicrob. Agents Chemother. 2008 52: 45-53. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Shannon Zelina, Chih-Wei Sheen, Jessica Radzio, John W. Mellors, and Nicolas Sluis-Cremer

Mechanisms by Which the G333D Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Facilitates Dual Resistance to Zidovudine and Lamivudine
Antimicrob. Agents Chemother. 2008 52: 157-163. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Angela H. A. M. van Hoek, Sigrid Mayrhofer, Konrad J. Domig, Ana B. Flórez, Mohammed S. Ammor, Baltasar Mayo, and Henk J. M. Aarts

Mosaic Tetracycline Resistance Genes and Their Flanking Regions in Bifidobacterium thermophilum and Lactobacillus johnsonii
Antimicrob. Agents Chemother. 2008 52: 248-252. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tiffanny Jones, Michael R. Yeaman, George Sakoulas, Soo-Jin Yang, Richard A. Proctor, Hans-Georg Sahl, Jacques Schrenzel, Yan Q. Xiong, and Arnold S. Bayer

Failures in Clinical Treatment of Staphylococcus aureus Infection with Daptomycin Are Associated with Alterations in Surface Charge, Membrane Phospholipid Asymmetry, and Drug Binding
Antimicrob. Agents Chemother. 2008 52: 269-278. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David A. Boyd, Xiaolu Shi, Qing-hua Hu, Lai King Ng, Benoit Doublet, Axel Cloeckaert, and Michael R. Mulvey

Salmonella Genomic Island 1 (SGI1), Variant SGI1-I, and New Variant SGI1-O in Proteus mirabilis Clinical and Food Isolates from China
Antimicrob. Agents Chemother. 2008 52: 340-344. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nanhua Chen, Qi Gao, Shanqing Wang, Guangze Wang, Michelle Gatton, and Qin Cheng

No Genetic Bottleneck in Plasmodium falciparum Wild-Type Pfcrt Alleles Reemerging in Hainan Island, China, following High-Level Chloroquine Resistance
Antimicrob. Agents Chemother. 2008 52: 345-347. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Miyuki Morozumi, Satoshi Iwata, Keiko Hasegawa, Naoko Chiba, Reiko Takayanagi, Keita Matsubara, Eiichi Nakayama, Keisuke Sunakawa, Kimiko Ubukata the Acute Respiratory Diseases Study Group

Increased Macrolide Resistance of Mycoplasma pneumoniae in Pediatric Patients with Community-Acquired Pneumonia
Antimicrob. Agents Chemother. 2008 52: 348-350. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Aaron M. Lynne, Bobbie S. Rhodes-Clark, Kimberly Bliven, Shaohua Zhao, and Steven L. Foley

Antimicrobial Resistance Genes Associated with Salmonella enterica Serovar Newport Isolates from Food Animals
Antimicrob. Agents Chemother. 2008 52: 353-356. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Emanuela Balestrieri, Claudia Matteucci, Arianna Ascolani, Anna Piperno, Roberto Romeo, Giovanni Romeo, Ugo Chiacchio, Antonio Mastino, and Beatrice Macchi

Effect of Phosphonated Carbocyclic 2'-Oxa-3'-Aza-Nucleoside on Human T-Cell Leukemia Virus Type 1 Infection In Vitro
Antimicrob. Agents Chemother. 2008 52: 54-64. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yi Zhou, Doug J. Bartels, Brian L. Hanzelka, Ute Müh, Yunyi Wei, Hui-May Chu, Ann M. Tigges, Debra L. Brennan, B. Govinda Rao, Lora Swenson, Ann D. Kwong, and Chao Lin

Phenotypic Characterization of Resistant Val³⁶ Variants of Hepatitis C Virus NS3-4A Serine Protease
Antimicrob. Agents Chemother. 2008 52: 110-120. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Weihong Lai, Li Huang, Phong Ho, Zhijun Li, David Montefiori, and Chin-Ho Chen

Betulinic Acid Derivatives That Target gp120 and Inhibit Multiple Genetic Subtypes of Human Immunodeficiency Virus Type 1
Antimicrob. Agents Chemother. 2008 52: 128-136. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robert W. Buckheit, Jr., Tracy L. Hartman, Karen M. Watson, Sun-Gan Chung, and Eui-Hwan Cho

Comparative Evaluation of the Inhibitory Activities of a Series of Pyrimidinedione Congeners That Inhibit Human Immunodeficiency Virus Types 1 and 2
Antimicrob. Agents Chemother. 2008 52: 225-236. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Céline Deffrasnes, Marie-Ève Hamelin, Gregory A. Prince, and Guy Boivin

Identification and Evaluation of a Highly Effective Fusion Inhibitor for Human Metapneumovirus
Antimicrob. Agents Chemother. 2008 52: 279-287. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Helen Cooksley, Shilpa Chokshi, Yafit Maayan, Heiner Wedemeyer, Pietro Andreone, Richard Gilson, Thomas Warnes, Simona Paganin, Fabien Zoulim, David Frederick, Avidan U. Neumann, Carol L. Brosgart, and Nikolai V. Naoumov

Hepatitis B Virus e Antigen Loss during Adefovir Dipivoxil Therapy Is Associated with Enhanced Virus-Specific CD4⁺ T-Cell Reactivity
Antimicrob. Agents Chemother. 2008 52: 312-320. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robert A. Smith, Geoffrey S. Gottlieb, Donovan J. Anderson, Crystal L. Pyrak, and Bradley D. Preston

Human Immunodeficiency Virus Types 1 and 2 Exhibit Comparable Sensitivities to Zidovudine and Other Nucleoside Analog Inhibitors In Vitro
Antimicrob. Agents Chemother. 2008 52: 329-332. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christophe Marchand, John A. Beutler, Antony Wamiru, Scott Budihas, Ute Möllmann, Lothar Heinisch, John W. Mellors, Stuart F. Le Grice, and Yves Pommier

Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H
Antimicrob. Agents Chemother. 2008 52: 361-364. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Kazuki Hoshino, Kazue Inoue, Yoichi Murakami, Yuichi Kurosaka, Kenji Namba, Yoshinori Kashimoto, Saori Uoyama, Ryo Okumura, Saito Higuchi, and Tsuyoshi Otani

In Vitro and In Vivo Antibacterial Activities of DC-159a, a New Fluoroquinolone
Antimicrob. Agents Chemother. 2008 52: 65-76. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Catherine Clark, Kathy Smith, Lois Ednie, Tatiana Bogdanovich, Bonifacio Dewasse, Pamela McGhee, and Peter C. Appelbaum

In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci
Antimicrob. Agents Chemother. 2008 52: 77-84. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Maria Luisa Mangoni, Giuseppantonio Maisetta, Mariagrazia Di Luca, Ludovica Marcellini Hercolani Gaddi, Semih Esin, Walter Florio, Franca Lisa Brancatisano, Donatella Barra, Mario Campa, and Giovanna Batoni

Comparative Analysis of the Bactericidal Activities of Amphibian Peptide Analogues against Multidrug-Resistant Nosocomial Bacterial Strains
Antimicrob. Agents Chemother. 2008 52: 85-91. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yoshifumi Imamura, Jyotsna Chandra, Pranab K. Mukherjee, Ali Abdul Lattif, Loretta B. Szczotka-Flynn, Eric Pearlman, Jonathan H. Lass, Kerry O'Donnell, and Mahmoud A. Ghannoum

Fusarium and Candida albicans Biofilms on Soft Contact Lenses: Model Development, Influence of Lens Type, and Susceptibility to Lens Care Solutions
Antimicrob. Agents Chemother. 2008 52: 171-182. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Janice R. Sufrin, Arthur J. Spiess, Canio J. Marasco, Jr., Donna Rattendi, and Cyrus J. Bacchi

Novel Trypanocidal Analogs of 5'-(Methylthio)-Adenosine
Antimicrob. Agents Chemother. 2008 52: 211-219. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Eric Legrand, Béatrice Volney, Jean-Baptiste Meynard, Odile Mercereau-Puijalon, and Philippe Esterre

In Vitro Monitoring of Plasmodium falciparum Drug Resistance in French Guiana: a Synopsis of Continuous Assessment from 1994 to 2005
Antimicrob. Agents Chemother. 2008 52: 288-298. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Charalampos Antachopoulos, Joseph Meletiadis, Tin Sein, Emmanuel Roilides, and Thomas J. Walsh

Comparative In Vitro Pharmacodynamics of Caspofungin, Micafungin, and Anidulafungin against Germinated and Nongerminated Aspergillus Conidia
Antimicrob. Agents Chemother. 2008 52: 321-328. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Glenn A. Pankuch, Gengrong Lin, Harald Seifert, and Peter C. Appelbaum

Activity of Meropenem with and without Ciprofloxacin and Colistin against Pseudomonas aeruginosa and Acinetobacter baumannii
Antimicrob. Agents Chemother. 2008 52: 333-336. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Marisa Haenni and Philippe Moreillon

Fitness Cost and Impaired Survival in Penicillin-Resistant Streptococcus gordonii Isolates Selected in the Laboratory
Antimicrob. Agents Chemother. 2008 52: 337-339. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Joshua S. Hawley, Clinton K. Murray, and James H. Jorgensen

Colistin Heteroresistance in Acinetobacter and Its Association with Previous Colistin Therapy
Antimicrob. Agents Chemother. 2008 52: 351-352. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Aspasia Katragkou, Athanasios Chatzimoschou, Maria Simitsopoulou, Maria Dalakiouridou, Eudoxia Diza-Mataftsi, Chaido Tsantali, and Emmanuel Roilides

Differential Activities of Newer Antifungal Agents against Candida albicans and Candida parapsilosis Biofilms
Antimicrob. Agents Chemother. 2008 52: 357-360. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kim L. Credito, Lois M. Ednie, and Peter C. Appelbaum

Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis
Antimicrob. Agents Chemother. 2008 52: 365-373. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Mark H. Gotfried, Jeng-Pyng Shaw, Bret M. Benton, Kevin M. Krause, Michael R. Goldberg, Michael M. Kitt, and Steven L. Barriere

Intrapulmonary Distribution of Intravenous Telavancin in Healthy Subjects and Effect of Pulmonary Surfactant on In Vitro Activities of Telavancin and Other Antibiotics
Antimicrob. Agents Chemother. 2008 52: 92-97. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Maria del Pilar Crespo, Thomas D. Avery, Eric Hanssen, Emma Fox, Tony V. Robinson, Peter Valente, Dennis K. Taylor, and Leann Tilley

Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology
Antimicrob. Agents Chemother. 2008 52: 98-109. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Timothy D. Starner, Joshua D. Shrout, Matthew R. Parsek, Peter C. Appelbaum, and GunHee Kim

Subinhibitory Concentrations of Azithromycin Decrease Nontypeable Haemophilus influenzae Biofilm Formation and Diminish Established Biofilms
Antimicrob. Agents Chemother. 2008 52: 137-145. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jun Matsumoto, Kimitoshi Sakamoto, Noriko Shinjyo, Yasutoshi Kido, Nao Yamamoto, Kinpei Yagi, Hideto Miyoshi, Nariaki Nonaka, Ken Katakura, Kiyoshi Kita, and Yuzaburo Oku

Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis, Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis
Antimicrob. Agents Chemother. 2008 52: 164-170. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kathrin Buchholz, R. Heiner Schirmer, Jana K. Eubel, Monique B. Akoachere, Thomas Dandekar, Katja Becker, and Stephan Gromer

Interactions of Methylene Blue with Human Disulfide Reductases and Their Orthologues from Plasmodium falciparum
Antimicrob. Agents Chemother. 2008 52: 183-191. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Allison Adonizio, Kok-Fai Kong, and Kalai Mathee

Inhibition of Quorum Sensing-Controlled Virulence Factor Production in Pseudomonas aeruginosa by South Florida Plant Extracts
Antimicrob. Agents Chemother. 2008 52: 198-203. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Arpita Chatterjee and Rukhsana Chowdhury

Bile and Unsaturated Fatty Acids Inhibit the Binding of Cholera Toxin and Escherichia coli Heat-Labile Enterotoxin to GM1 Receptor
Antimicrob. Agents Chemother. 2008 52: 220-224. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jeremiah W. Hanes and Kenneth A. Johnson

Exonuclease Removal of Dideoxycytidine (Zalcitabine) by the Human Mitochondrial DNA Polymerase
Antimicrob. Agents Chemother. 2008 52: 253-258. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Mitsuhiro Iyori, Hideo Kataoka, Haque Mohammad Shamsul, Kazuto Kiura, Motoaki Yasuda, Takashi Nakata, Akira Hasebe, and Ken-ichiro Shibata

Resveratrol Modulates Phagocytosis of Bacteria through an NF-B-Dependent Gene Program
Antimicrob. Agents Chemother. 2008 52: 121-127. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Analytical Procedures:

Peter Staib, Ulrich Lermann, Julia Blaβ-Warmuth, Björn Degel, Reinhard Würzner, Michel Monod, Tanja Schirmeister, and Joachim Morschhäuser

Tetracycline-Inducible Expression of Individual Secreted Aspartic Proteases in Candida albicans Allows Isoenzyme-Specific Inhibitor Screening
Antimicrob. Agents Chemother. 2008 52: 146-156. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

David C. Griffith, David Rodriguez, Erik Corcoran, and Michael N. Dudley

Pharmacodynamics of RWJ-54428 against Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis in a Neutropenic Mouse Thigh Infection Model
Antimicrob. Agents Chemother. 2008 52: 244-247. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jon A. Olson, Jill P. Adler-Moore, Gerard M. Jensen, Julie Schwartz, M. Cecilia Dignani, and Richard T. Proffitt

Comparison of the Physicochemical, Antifungal, and Toxic Properties of Two Liposomal Amphotericin B Products
Antimicrob. Agents Chemother. 2008 52: 259-268. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mrinalini Sharma, Livia Visai, Francesca Bragheri, Ilaria Cristiani, Pradeep Kumar Gupta, and Pietro Speziale

Toluidine Blue-Mediated Photodynamic Effects on Staphylococcal Biofilms
Antimicrob. Agents Chemother. 2008 52: 299-305. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Brioni R. Moore, Kevin T. Batty, Christopher Andrzejewski, Jeffrey D. Jago, Madhu Page-Sharp, and Kenneth F. Ilett

Pharmacokinetics and Pharmacodynamics of Piperaquine in a Murine Malaria Model
Antimicrob. Agents Chemother. 2008 52: 306-311. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Partha Palit and Nahid Ali

Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis
Antimicrob. Agents Chemother. 2008 52: 374-377. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Patrick F. McDermott, Laura M. McMurry, Isabelle Podglajen, JoAnn L. Dzink-Fox, Thamarai Schneiders, Michael P. Draper, and Stuart B. Levy

The marC Gene of Escherichia coli Is Not Involved in Multiple Antibiotic Resistance
Antimicrob. Agents Chemother. 2008 52: 382-383. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.