Contents: October 2008, Volume 52, Issue 10        Experimental Therapeutics        Pharmacology        Antiviral Agents        Susceptibility        Mechanisms of Resistance        Mechanisms of Action        Clinical Therapeutics        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Experimental Therapeutics:

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Antimalarial Activity of Phenylthiazolyl-Bearing Hydroxamate-Based Histone Deacetylase Inhibitors Geoffrey S. Dow, Yufeng Chen, Katherine T. Andrews, Diana Caridha, Lucia Gerena, Montip Gettayacamin, Jacob Johnson, Qigui Li, Victor Melendez, Nicanor Obaldia, III, Thanh N. Tran, and Alan P. Kozikowski Antimicrob. Agents Chemother. October 2008 52: 3467-3477; published ahead of print July 21, 2008, doi:10.1128/AAC.00439-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

In Vivo Pharmacodynamic Target Investigation for Micafungin against Candida albicans and C. glabrata in a Neutropenic Murine Candidiasis Model D. R. Andes, D. J. Diekema, M. A. Pfaller, K. Marchillo, and J. Bohrmueller Antimicrob. Agents Chemother. October 2008 52: 3497-3503; published ahead of print July 14, 2008, doi:10.1128/AAC.00478-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of the Interaction of R207910 with Rifampin on the Treatment of Tuberculosis Studied in the Mouse Model Nacer Lounis, Tom Gevers, Joke Van Den Berg, and Koen Andries Antimicrob. Agents Chemother. October 2008 52: 3568-3572; published ahead of print July 21, 2008, doi:10.1128/AAC.00566-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhanced Bactericidal Activity of Rifampin and/or Pyrazinamide When Combined with PA-824 in a Murine Model of Tuberculosis Rokeya Tasneen, Sandeep Tyagi, Kathy Williams, Jacques Grosset, and Eric Nuermberger Antimicrob. Agents Chemother. October 2008 52: 3664-3668; published ahead of print August 11, 2008, doi:10.1128/AAC.00686-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae M. Mar Rodríguez, Carolina Serena, Marçal Mariné, F. Javier Pastor, and Josep Guarro Antimicrob. Agents Chemother. October 2008 52: 3786-3788; published ahead of print August 11, 2008, doi:10.1128/AAC.00628-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Disposition, Metabolism, and Excretion of [14C]Doripenem after a Single 500-Milligram Intravenous Infusion in Healthy Men Iolanda Cirillo, Geert Mannens, Cor Janssen, Marc Vermeir, Filip Cuyckens, Daksha Desai-Krieger, Nicole Vaccaro, L. Mark Kao, Damayanthi Devineni, Rebecca Redman, and Kenneth Turner Antimicrob. Agents Chemother. October 2008 52: 3478-3483; published ahead of print July 21, 2008, doi:10.1128/AAC.00424-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Pharmacodynamics of Ceftobiprole against Multiple Bacterial Pathogens in Murine Thigh and Lung Infection Models W. A. Craig and D. R. Andes Antimicrob. Agents Chemother. October 2008 52: 3492-3496; published ahead of print August 1, 2008, doi:10.1128/AAC.01273-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antagonistic Effect of Rifampin on the Efficacy of High-Dose Levofloxacin in Staphylococcal Experimental Foreign-Body Infection O. Murillo, M. E. Pachón, G. Euba, R. Verdaguer, F. Tubau, C. Cabellos, J. Cabo, F. Gudiol, and J. Ariza Antimicrob. Agents Chemother. October 2008 52: 3681-3686; published ahead of print August 1, 2008, doi:10.1128/AAC.00458-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases Keiko Hata, Koichi Koseki, Kazunori Yamaguchi, Setsuko Moriya, Yasuo Suzuki, Sangchai Yingsakmongkon, Go Hirai, Mikiko Sodeoka, Mark von Itzstein, and Taeko Miyagi Antimicrob. Agents Chemother. October 2008 52: 3484-3491; published ahead of print August 11, 2008, doi:10.1128/AAC.00344-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors Koleen J. Herlihy, Joanne P. Graham, Robert Kumpf, Amy K. Patick, Rohit Duggal, and Stephanie T. Shi Antimicrob. Agents Chemother. October 2008 52: 3523-3531; published ahead of print August 11, 2008, doi:10.1128/AAC.00533-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Inhibitors of Strand Transfer That Prevent Integration and Inhibit Human T-Cell Leukemia Virus Type 1 Early Replication Samira Rabaaoui, Fatima Zouhiri, Agnès Lançon, Hervé Leh, Jean d'Angelo, and Eric Wattel Antimicrob. Agents Chemother. October 2008 52: 3532-3541; published ahead of print March 3, 2008, doi:10.1128/AAC.01361-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Effects of Lamivudine, Emtricitabine, Adefovir Dipivoxil, and Tenofovir Disoproxil Fumarate Administered Orally Alone and in Combination to Woodchucks with Chronic Woodchuck Hepatitis Virus Infection Stephan Menne, Scott D. Butler, Andrea L. George, Ilia A. Tochkov, Yuao Zhu, Shelly Xiong, John L. Gerin, Paul J. Cote, and Bud C. Tennant Antimicrob. Agents Chemother. October 2008 52: 3617-3632; published ahead of print August 1, 2008, doi:10.1128/AAC.00654-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of the Small Modified Amino Acid -Hydroxy Glycineamide on In Vitro and In Vivo Human Immunodeficiency Virus Type 1 Capsid Assembly and Infectivity Samir Abdurahman, Ákos Végvári, Masoud Youssefi, Michael Levi, Stefan Höglund, Elin Andersson, Peter Horal, Bo Svennerholm, Jan Balzarini, and Anders Vahlne Antimicrob. Agents Chemother. October 2008 52: 3737-3744; published ahead of print July 21, 2008, doi:10.1128/AAC.00265-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Establishing In Vitro-In Vivo Correlations for Aspergillus fumigatus: the Challenge of Azoles versus Echinocandins Maiken Cavling Arendrup, Susanne Perkhofer, Susan J. Howard, Guillermo Garcia-Effron, Aimanianda Vishukumar, David Perlin, and Cornelia Lass-Flörl Antimicrob. Agents Chemother. October 2008 52: 3504-3511; published ahead of print July 21, 2008, doi:10.1128/AAC.00190-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Microbial Growth Inhibition by Alternating Electric Fields Moshe Giladi, Yaara Porat, Alexandra Blatt, Yoram Wasserman, Eilon D. Kirson, Erez Dekel, and Yoram Palti Antimicrob. Agents Chemother. October 2008 52: 3517-3522; published ahead of print July 28, 2008, doi:10.1128/AAC.00673-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ceftibuten Resistance and Treatment Failure of Neisseria gonorrhoeae Infection Janice Y. C. Lo, K. M. Ho, Anna O. C. Leung, Felisa S. T. Tiu, Grand K. L. Tsang, Angus C. T. Lo, and John W. Tapsall Antimicrob. Agents Chemother. October 2008 52: 3564-3567; published ahead of print July 28, 2008, doi:10.1128/AAC.00198-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection and Persistence of CTX-M-Producing Escherichia coli in the Intestinal Flora of Pigs Treated with Amoxicillin, Ceftiofur, or Cefquinome L. M. Cavaco, E. Abatih, F. M. Aarestrup, and L. Guardabassi Antimicrob. Agents Chemother. October 2008 52: 3612-3616; published ahead of print July 21, 2008, doi:10.1128/AAC.00354-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Antifungal Agents against Yeasts and Filamentous Fungi: Assessment according to the Methodology of the European Committee on Antimicrobial Susceptibility Testing Cornelia Lass-Flörl, Astrid Mayr, Susanne Perkhofer, Guido Hinterberger, Johann Hausdorfer, Cornelia Speth, and Manfred Fille Antimicrob. Agents Chemother. October 2008 52: 3637-3641; published ahead of print August 11, 2008, doi:10.1128/AAC.00662-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Hydroxyurea against Leishmania mexicana Hugo Martinez-Rojano, Javier Mancilla-Ramirez, Laura Quiñonez-Diaz, and Norma Galindo-Sevilla Antimicrob. Agents Chemother. October 2008 52: 3642-3647; published ahead of print August 11, 2008, doi:10.1128/AAC.00124-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy Kayode K. Ojo, J. Robert Gillespie, Aaron J. Riechers, Alberto J. Napuli, Christophe L. M. J. Verlinde, Frederick S. Buckner, Michael H. Gelb, Mathias M. Domostoj, Susan J. Wells, Alexander Scheer, Timothy N. C. Wells, and Wesley C. Van Voorhis Antimicrob. Agents Chemother. October 2008 52: 3710-3717; published ahead of print July 21, 2008, doi:10.1128/AAC.00364-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CYP56 (Dit2p) in Candida albicans: Characterization and Investigation of Its Role in Growth and Antifungal Drug Susceptibility N. R. Melo, G. P. Moran, A. G. S. Warrilow, E. Dudley, S. N. Smith, D. J. Sullivan, D. C. Lamb, D. E. Kelly, D. C. Coleman, and S. L. Kelly Antimicrob. Agents Chemother. October 2008 52: 3718-3724; published ahead of print July 28, 2008, doi:10.1128/AAC.00446-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activity of DC-159a, a New Fluoroquinolone, against 1,149 Recently Collected Clinical Isolates Ronald N. Jones, Thomas R. Fritsche, and Helio S. Sader Antimicrob. Agents Chemother. October 2008 52: 3763-3775; published ahead of print June 23, 2008, doi:10.1128/AAC.00294-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Activities of the Investigational Fluoroquinolone DC-159a and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas Ken B. Waites, Donna M. Crabb, and Lynn B. Duffy Antimicrob. Agents Chemother. October 2008 52: 3776-3778; published ahead of print July 28, 2008, doi:10.1128/AAC.00849-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Enhances the Mutation Frequency for Meropenem-Selected Carbapenem Resistance in Pseudomonas aeruginosa, but Use of the High-Potency Drug Doripenem Inhibits Mutant Formation Koichi Tanimoto, Haruyoshi Tomita, Shuhei Fujimoto, Katsuko Okuzumi, and Yasuyoshi Ike Antimicrob. Agents Chemother. October 2008 52: 3795-3800; published ahead of print August 11, 2008, doi:10.1128/AAC.00464-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Surveillance of Community-Based Reservoirs Reveals the Presence of CTX-M, Imported AmpC, and OXA-30 β-Lactamases in Urine Isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. Community Nancy D. Hanson, Ellen Smith Moland, S. G. Hong, Katie Propst, Deborah J. Novak, and Stephen J. Cavalieri Antimicrob. Agents Chemother. October 2008 52: 3814-3816; published ahead of print July 28, 2008, doi:10.1128/AAC.00877-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance of Old and Recent Staphylococcus aureus Isolates from Poultry: First Detection of Livestock-Associated Methicillin-Resistant Strain ST398 Mostafa Nemati, Katleen Hermans, Urszula Lipinska, Olivier Denis, Ariane Deplano, Marc Struelens, Luc A. Devriese, Frank Pasmans, and Freddy Haesebrouck Antimicrob. Agents Chemother. October 2008 52: 3817-3819; published ahead of print July 28, 2008, doi:10.1128/AAC.00613-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessment by Time-Kill Methodology of the Synergistic Effects of Oritavancin in Combination with Other Antimicrobial Agents against Staphylococcus aureus Adam Belley, Eve Neesham-Grenon, Francis F. Arhin, Geoffrey A. McKay, Thomas R. Parr, Jr., and Gregory Moeck Antimicrob. Agents Chemother. October 2008 52: 3820-3822; published ahead of print July 21, 2008, doi:10.1128/AAC.00361-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Novel Type of Staphylococcal Cassette Chromosome mec in a Methicillin-Resistant Staphylococcus aureus Strain Isolated in Sweden Carolina Berglund, Teruyo Ito, Megumi Ikeda, Xiao Xue Ma, Bo Söderquist, and Keiichi Hiramatsu Antimicrob. Agents Chemother. October 2008 52: 3512-3516; published ahead of print August 1, 2008, doi:10.1128/AAC.00087-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Macrolide Resistance in Mycoplasma pneumoniae by Real-Time PCR and High-Resolution Melt Analysis Bernard J. Wolff, W. Lanier Thacker, Stephanie B. Schwartz, and Jonas M. Winchell Antimicrob. Agents Chemother. October 2008 52: 3542-3549; published ahead of print July 21, 2008, doi:10.1128/AAC.00582-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of an ABCG-Like Transporter from the Protozoan Parasite Leishmania with a Role in Drug Resistance and Transbilayer Lipid Movement Esther Castanys-Muñoz, José María Pérez-Victoria, Francisco Gamarro, and Santiago Castanys Antimicrob. Agents Chemother. October 2008 52: 3573-3579; published ahead of print July 21, 2008, doi:10.1128/AAC.00587-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

An O-Phosphotransferase Catalyzes Phosphorylation of Hygromycin A in the Antibiotic-Producing Organism Streptomyces hygroscopicus Vidya Dhote, Shuchi Gupta, and Kevin A. Reynolds Antimicrob. Agents Chemother. October 2008 52: 3580-3588; published ahead of print July 21, 2008, doi:10.1128/AAC.00157-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the New Metallo-β-Lactamase VIM-13 and Its Integron-Borne Gene from a Pseudomonas aeruginosa Clinical Isolate in Spain Carlos Juan, Alejandro Beceiro, Olivia Gutiérrez, Sebastián Albertí, Margalida Garau, José L. Pérez, Germán Bou, and Antonio Oliver Antimicrob. Agents Chemother. October 2008 52: 3589-3596; published ahead of print July 21, 2008, doi:10.1128/AAC.00465-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine Andrew M. Bailey, Ian T. Paulsen, and Laura J. V. Piddock Antimicrob. Agents Chemother. October 2008 52: 3604-3611; published ahead of print August 11, 2008, doi:10.1128/AAC.00661-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Adaptive Response and Survival of Salmonella enterica Serovar Enteritidis Planktonic and Biofilm Cells Exposed to Benzalkonium Chloride Anil K. Mangalappalli-Illathu, Sinisa Vidovic, and Darren R. Korber Antimicrob. Agents Chemother. October 2008 52: 3669-3680; published ahead of print July 28, 2008, doi:10.1128/AAC.00073-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Benefit of Having Multiple ampD Genes for Acquiring β-Lactam Resistance without Losing Fitness and Virulence in Pseudomonas aeruginosa Bartolomé Moya, Carlos Juan, Sebastián Albertí, José L. Pérez, and Antonio Oliver Antimicrob. Agents Chemother. October 2008 52: 3694-3700; published ahead of print July 21, 2008, doi:10.1128/AAC.00172-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Nonsense Mutation in the ERG6 Gene Leads to Reduced Susceptibility to Polyenes in a Clinical Isolate of Candida glabrata Patrick Vandeputte, Guy Tronchin, Gérald Larcher, Emilie Ernoult, Thierry Bergès, Dominique Chabasse, and Jean-Philippe Bouchara Antimicrob. Agents Chemother. October 2008 52: 3701-3709; published ahead of print August 11, 2008, doi:10.1128/AAC.00423-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A β-Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France Stephanie Petrella, Nathalie Ziental-Gelus, Claudine Mayer, Murielle Renard, Vincent Jarlier, and Wladimir Sougakoff Antimicrob. Agents Chemother. October 2008 52: 3725-3736; published ahead of print July 14, 2008, doi:10.1128/AAC.00163-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Insertion Sequence- and Transposon-Mediated Genetic Rearrangements in Genomic Island SGI1 of Salmonella enterica Serovar Kentucky Benoît Doublet, Karine Praud, Sophie Bertrand, Jean-Marc Collard, François-Xavier Weill, and Axel Cloeckaert Antimicrob. Agents Chemother. October 2008 52: 3745-3754; published ahead of print August 1, 2008, doi:10.1128/AAC.00525-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus Benjamin P. Howden, Timothy P. Stinear, David L. Allen, Paul D. R. Johnson, Peter B. Ward, and John K. Davies Antimicrob. Agents Chemother. October 2008 52: 3755-3762; published ahead of print July 21, 2008, doi:10.1128/AAC.01613-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection George R. Thompson, III, Nathan P. Wiederhold, Ana C. Vallor, Nyria C. Villareal, James S. Lewis, II, and Thomas F. Patterson Antimicrob. Agents Chemother. October 2008 52: 3783-3785; published ahead of print August 1, 2008, doi:10.1128/AAC.00473-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evolution of the ISCR3 Group of ISCR Elements Mark A. Toleman and Timothy R. Walsh Antimicrob. Agents Chemother. October 2008 52: 3789-3791; published ahead of print July 28, 2008, doi:10.1128/AAC.00479-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from Klebsiella pneumoniae Véronique Dubois, Laurent Poirel, François Demarthe, Corinne Arpin, Laure Coulange, Luciene A. R. Minarini, Marie-Christine Bezian, Patrice Nordmann, and Claudine Quentin Antimicrob. Agents Chemother. October 2008 52: 3792-3794; published ahead of print July 28, 2008, doi:10.1128/AAC.00387-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated Quinolone Resistance Pump QepA2 in an Escherichia coli Isolate from France Vincent Cattoir, Laurent Poirel, and Patrice Nordmann Antimicrob. Agents Chemother. October 2008 52: 3801-3804; published ahead of print July 21, 2008, doi:10.1128/AAC.00638-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Structure Analysis of the Mycobacterium tuberculosis Beijing Family Indicates an Association between Certain Sublineages and Multidrug Resistance Tomotada Iwamoto, Shiomi Yoshida, Katsuhiro Suzuki, and Takayuki Wada Antimicrob. Agents Chemother. October 2008 52: 3805-3809; published ahead of print August 11, 2008, doi:10.1128/AAC.00579-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Mutator Genes Giving Rise to Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Irith Wiegand, Alexandra K. Marr, Elena B. M. Breidenstein, Kristen N. Schurek, Patrick Taylor, and Robert E. W. Hancock Antimicrob. Agents Chemother. October 2008 52: 3810-3813; published ahead of print July 28, 2008, doi:10.1128/AAC.00233-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Smqnr, a New Chromosome-Carried Quinolone Resistance Gene in Stenotrophomonas maltophilia Kenichiro Shimizu, Ken Kikuchi, Takashi Sasaki, Namiko Takahashi, Masayuki Ohtsuka, Yuka Ono, and Keiichi Hiramatsu Antimicrob. Agents Chemother. October 2008 52: 3823-3825; published ahead of print July 21, 2008, doi:10.1128/AAC.00026-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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R-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance Eugene Skripkin, Timothy S. McConnell, Joseph DeVito, Laura Lawrence, Joseph A. Ippolito, Erin M. Duffy, Joyce Sutcliffe, and François Franceschi Antimicrob. Agents Chemother. October 2008 52: 3550-3557; published ahead of print July 28, 2008, doi:10.1128/AAC.01193-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14-Demethylase at the Homologous Locus J. E. Parker, M. Merkamm, N. J. Manning, D. Pompon, S. L. Kelly, and D. E. Kelly Antimicrob. Agents Chemother. October 2008 52: 3597-3603; published ahead of print August 11, 2008, doi:10.1128/AAC.00517-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penetration of Chlorhexidine into Human Skin T. J. Karpanen, T. Worthington, B. R. Conway, A. C. Hilton, T. S. J. Elliott, and P. A. Lambert Antimicrob. Agents Chemother. October 2008 52: 3633-3636; published ahead of print August 1, 2008, doi:10.1128/AAC.00637-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa Mette E. Skindersoe, Morten Alhede, Richard Phipps, Liang Yang, Peter O. Jensen, Thomas B. Rasmussen, Thomas Bjarnsholt, Tim Tolker-Nielsen, Niels Høiby, and Michael Givskov Antimicrob. Agents Chemother. October 2008 52: 3648-3663; published ahead of print July 21, 2008, doi:10.1128/AAC.01230-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Edelfosine Induces an Apoptotic Process in Leishmania infantum That Is Regulated by the Ectopic Expression of Bcl-XL and Hrk Juan Fernando Alzate, Andrés Arias, Faustino Mollinedo, Eva Rico, Janis de la Iglesia-Vicente, and Antonio Jiménez-Ruiz Antimicrob. Agents Chemother. October 2008 52: 3779-3782; published ahead of print July 21, 2008, doi:10.1128/AAC.01665-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Peptide Nucleic Acid Fluorescent In Situ Hybridization for Hospital-Acquired Enterococcal Bacteremia: Delivering Earlier Effective Antimicrobial Therapy Graeme N. Forrest, Mary-Claire Roghmann, Latoya S. Toombs, Jennifer K. Johnson, Elizabeth Weekes, Durry P. Lincalis, and Richard A. Venezia Antimicrob. Agents Chemother. October 2008 52: 3558-3563; published ahead of print July 28, 2008, doi:10.1128/AAC.00283-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Low Penetration of Oseltamivir and Its Carboxylate into Cerebrospinal Fluid in Healthy Japanese and Caucasian Volunteers S. S. Jhee, M. Yen, L. Ereshefsky, M. Leibowitz, M. Schulte, B. Kaeser, L. Boak, A. Patel, G. Hoffmann, E. P. Prinssen, and C. R. Rayner Antimicrob. Agents Chemother. October 2008 52: 3687-3693; published ahead of print August 1, 2008, doi:10.1128/AAC.00327-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Antimicrobial Studies with the Pseudomonas aeruginosa Two-Allele Library Require Caution Xiangli Wu, Hexiang Wang, and Xilin Zhao Antimicrob. Agents Chemother. October 2008 52: 3826-3827; published ahead of print August 11, 2008, doi:10.1128/AAC.00419-08 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Systemic Expression of Cytokine Production in Patients with Severe Pneumococcal Pneumonia: Effects of Treatment with a β-Lactam versus a Fluoroquinolone Esther Calbo, Montserrat Alsina, Mónica Rodríguez-Carballeira, Josep Lite, and Javier Garau Antimicrob. Agents Chemother. October 2008 52: 3828 [Full Text] [PDF] [Reprints and Permissions]

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