Contents: November 2008, Volume 52, Issue 11        Mechanisms of Resistance        Mechanisms of Action        Susceptibility        Chemistry; Biosynthesis        Antiviral Agents        Pharmacology        Clinical Therapeutics        Experimental Therapeutics        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Resistance:

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Vibrio cholerae O139 Multiple-Drug Resistance Mediated by Yersinia pestis pIP1202-Like Conjugative Plasmids Jing-Cao Pan, Rong Ye, Hao-Qiu Wang, Hai-Qing Xiang, Wei Zhang, Xin-Fen Yu, Dong-Mei Meng, and Zhe-Sheng He Antimicrob. Agents Chemother. November 2008 52: 3829-3836; published ahead of print August 18, 2008, doi:10.1128/AAC.00375-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Basis of Multidrug Resistance in Acinetobacter baumannii Clinical Isolates at a Tertiary Medical Center in Pennsylvania Jennifer M. Adams-Haduch, David L. Paterson, Hanna E. Sidjabat, Anthony W. Pasculle, Brian A. Potoski, Carlene A. Muto, Lee H. Harrison, and Yohei Doi Antimicrob. Agents Chemother. November 2008 52: 3837-3843; published ahead of print August 25, 2008, doi:10.1128/AAC.00570-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

ABC Transporter Cdr1p Contributes More than Cdr2p Does to Fluconazole Efflux in Fluconazole-Resistant Candida albicans Clinical Isolates Ann R. Holmes, Ya-Hsun Lin, Kyoko Niimi, Erwin Lamping, Mikhail Keniya, Masakazu Niimi, Koichi Tanabe, Brian C. Monk, and Richard D. Cannon Antimicrob. Agents Chemother. November 2008 52: 3851-3862; published ahead of print August 18, 2008, doi:10.1128/AAC.00463-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmodium falciparum Strains Harboring Dihydrofolate Reductase with the I164L Mutation Are Absent in Malawi and Zambia Even under Antifolate Drug Pressure Edwin Ochong, David J. Bell, David J. Johnson, Umberto D'Alessandro, Modest Mulenga, Sant Muangnoicharoen, Jean-Pierre Van Geertruyden, Peter A. Winstanley, Patrick G. Bray, Stephen A. Ward, and Andrew Owen Antimicrob. Agents Chemother. November 2008 52: 3883-3888; published ahead of print August 25, 2008, doi:10.1128/AAC.00431-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Structure Associated with blaOXA-18, Encoding a Clavulanic Acid-Inhibited Extended-Spectrum Oxacillinase Thierry Naas, Fatemeh Namdari, Pierre Bogaerts, Te-Din Huang, Youri Glupczynski, and Patrice Nordmann Antimicrob. Agents Chemother. November 2008 52: 3898-3904; published ahead of print July 28, 2008, doi:10.1128/AAC.00403-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence and Mechanisms of Broad-Spectrum β-Lactam Resistance in Enterobacteriaceae: a Children's Hospital Experience Xuan Qin, Danielle M. Zerr, Scott J. Weissman, Janet A. Englund, Donna M. Denno, Eileen J. Klein, Phillip I. Tarr, Justin Kwong, Jennifer R. Stapp, Luis G. Tulloch, and Emmanouil Galanakis Antimicrob. Agents Chemother. November 2008 52: 3909-3914; published ahead of print September 2, 2008, doi:10.1128/AAC.00622-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones Nadezhda German, Muhammad Malik, Jonathan D. Rosen, Karl Drlica, and Robert J. Kerns Antimicrob. Agents Chemother. November 2008 52: 3915-3921; published ahead of print September 2, 2008, doi:10.1128/AAC.00330-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of ampD Homologs in Overproduction of AmpC in Clinical Isolates of Pseudomonas aeruginosa Amber J. Schmidtke and Nancy D. Hanson Antimicrob. Agents Chemother. November 2008 52: 3922-3927; published ahead of print September 8, 2008, doi:10.1128/AAC.00341-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Analysis of Fenhexamid-Resistant Field Isolates of the Phytopathogenic Fungus Botrytis cinerea Sabine Fillinger, Pierre Leroux, Christiane Auclair, Christian Barreau, Charbel Al Hajj, and Danièle Debieu Antimicrob. Agents Chemother. November 2008 52: 3933-3940; published ahead of print September 8, 2008, doi:10.1128/AAC.00615-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Development, Stability, and Molecular Mechanisms of Macrolide Resistance in Campylobacter jejuni Dave Bryson Caldwell, Ying Wang, and Jun Lin Antimicrob. Agents Chemother. November 2008 52: 3947-3954; published ahead of print September 8, 2008, doi:10.1128/AAC.00450-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Staphylococcus aureus PBP4 Is Essential for β-Lactam Resistance in Community-Acquired Methicillin-Resistant Strains Guido Memmi, Sergio R. Filipe, Mariana G. Pinho, Zhibiao Fu, and Ambrose Cheung Antimicrob. Agents Chemother. November 2008 52: 3955-3966; published ahead of print August 25, 2008, doi:10.1128/AAC.00049-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotypic Characterization of Two Ancylostoma caninum Isolates with Different Susceptibilities to the Anthelmintic Pyrantel Steven R. Kopp, Glen T. Coleman, James S. McCarthy, and Andrew C. Kotze Antimicrob. Agents Chemother. November 2008 52: 3980-3986; published ahead of print August 18, 2008, doi:10.1128/AAC.00523-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Tetracycline Efflux Gene, tet(40), Is Located in Tandem with tet(O/32/O) in a Human Gut Firmicute Bacterium and in Metagenomic Library Clones Katarzyna A. Kazimierczak, Marco T. Rincon, Andrea J. Patterson, Jennifer C. Martin, Pauline Young, Harry J. Flint, and Karen P. Scott Antimicrob. Agents Chemother. November 2008 52: 4001-4009; published ahead of print September 8, 2008, doi:10.1128/AAC.00308-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus Jonas Lannergård, Christof von Eiff, Gunnar Sander, Tina Cordes, Jochen Seggewiβ, Georg Peters, Richard A. Proctor, Karsten Becker, and Diarmaid Hughes Antimicrob. Agents Chemother. November 2008 52: 4017-4022; published ahead of print September 8, 2008, doi:10.1128/AAC.00668-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Countrywide Survey of Acquired Metallo-β-Lactamases in Gram-Negative Pathogens in Italy Gian Maria Rossolini, Francesco Luzzaro, Roberta Migliavacca, Claudia Mugnaioli, Beatrice Pini, Filomena De Luca, Mariagrazia Perilli, Simona Pollini, Melissa Spalla, Gianfranco Amicosante, Antonio Toniolo, and Laura Pagani Antimicrob. Agents Chemother. November 2008 52: 4023-4029; published ahead of print September 22, 2008, doi:10.1128/AAC.00707-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhanced Susceptibility to Antifungal Oligopeptides in Yeast Strains Overexpressing ABC Multidrug Efflux Pumps Roland Wakiec, Iwona Gabriel, Rajendra Prasad, Jeffrey M. Becker, John W. Payne, and Slawomir Milewski Antimicrob. Agents Chemother. November 2008 52: 4057-4063; published ahead of print September 15, 2008, doi:10.1128/AAC.01648-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hitchhiking and Selective Sweeps of Plasmodium falciparum Sulfadoxine and Pyrimethamine Resistance Alleles in a Population from Central Africa Andrea M. McCollum, Leonardo K. Basco, Rachida Tahar, Venkatachalam Udhayakumar, and Ananias A. Escalante Antimicrob. Agents Chemother. November 2008 52: 4089-4097; published ahead of print September 2, 2008, doi:10.1128/AAC.00623-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

A Plasmid-Borne blaOXA-58 Gene Confers Imipenem Resistance to Acinetobacter baumannii Isolates from a Lebanese Hospital Raffaele Zarrilli, Domenico Vitale, Anna Di Popolo, Maria Bagattini, Ziad Daoud, Asad U. Khan, Claude Afif, and Maria Triassi Antimicrob. Agents Chemother. November 2008 52: 4115-4120; published ahead of print August 25, 2008, doi:10.1128/AAC.00366-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aspergillus fumigatus Forms Biofilms with Reduced Antifungal Drug Susceptibility on Bronchial Epithelial Cells Marc J. Seidler, Stefanie Salvenmoser, and Frank-Michael C. Müller Antimicrob. Agents Chemother. November 2008 52: 4130-4136; published ahead of print August 18, 2008, doi:10.1128/AAC.00234-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Macrolide Antibiotic-Mediated Downregulation of MexAB-OprM Efflux Pump Expression in Pseudomonas aeruginosa Makoto Sugimura, Hideaki Maseda, Hideaki Hanaki, and Taiji Nakae Antimicrob. Agents Chemother. November 2008 52: 4141-4144; published ahead of print August 1, 2008, doi:10.1128/AAC.00511-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pyrosequencing To Detect Mutations in FKS1 That Confer Reduced Echinocandin Susceptibility in Candida albicans Nathan P. Wiederhold, Jodi L. Grabinski, Guillermo Garcia-Effron, David S. Perlin, and Samuel A. Lee Antimicrob. Agents Chemother. November 2008 52: 4145-4148; published ahead of print September 15, 2008, doi:10.1128/AAC.00959-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Recovery of a Functional Class 2 Integron from an Escherichia coli Strain Mediating a Urinary Tract Infection Carolina Márquez, Maurizio Labbate, Ana J. Ingold, Piklu Roy Chowdhury, Maria S. Ramírez, Daniela Centrón, Graciela Borthagaray, and H. W. Stokes Antimicrob. Agents Chemother. November 2008 52: 4153-4154; published ahead of print September 15, 2008, doi:10.1128/AAC.00710-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Real-Time PCR Detection of gyrA and parC Mutations in Streptococcus pneumoniae S. Page, F. Vernel-Pauillac, O. O'Connor, S. Bremont, F. Charavay, P. Courvalin, C. Goarant, and S. Le Hello Antimicrob. Agents Chemother. November 2008 52: 4155-4158; published ahead of print August 25, 2008, doi:10.1128/AAC.00082-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated Quinolone Resistance Determinants qnrA, qnrB, and qnrS among Clinical Isolates of Enterobacteriaceae in a Korean Hospital Migma Dorji Tamang, Sung Yong Seol, Jae-Young Oh, Hee Young Kang, Je Chul Lee, Yoo Chul Lee, Dong Taek Cho, and Jungmin Kim Antimicrob. Agents Chemother. November 2008 52: 4159-4162; published ahead of print August 25, 2008, doi:10.1128/AAC.01633-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of TolC Efflux Pump Proteins from Pasteurella multocida Tamas Hatfaludi, Keith Al-Hasani, Michelle Dunstone, John Boyce, and Ben Adler Antimicrob. Agents Chemother. November 2008 52: 4166-4171; published ahead of print August 25, 2008, doi:10.1128/AAC.00245-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Caspofungin-Resistant Candida tropicalis Strains Causing Breakthrough Fungemia in Patients at High Risk for Hematologic Malignancies Guillermo Garcia-Effron, Dimitrios P. Kontoyiannis, Russell E. Lewis, and David S. Perlin Antimicrob. Agents Chemother. November 2008 52: 4181-4183; published ahead of print September 15, 2008, doi:10.1128/AAC.00802-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interspecies Recombination Occurs Frequently in Quinolone Resistance-Determining Regions of Clinical Isolates of Streptococcus pyogenes Christoph B. Duesberg, Surbhi Malhotra-Kumar, Herman Goossens, Lesley McGee, Keith P. Klugman, Tobias Welte, and Mathias W. R. Pletz Antimicrob. Agents Chemother. November 2008 52: 4191-4193; published ahead of print September 2, 2008, doi:10.1128/AAC.00518-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

KHM-1, a Novel Plasmid-Mediated Metallo-β-Lactamase from a Citrobacter freundii Clinical Isolate Jun-ichiro Sekiguchi, Koji Morita, Tomoe Kitao, Noboru Watanabe, Mitsuhiro Okazaki, Tohru Miyoshi-Akiyama, Masato Kanamori, and Teruo Kirikae Antimicrob. Agents Chemother. November 2008 52: 4194-4197; published ahead of print September 2, 2008, doi:10.1128/AAC.01337-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dominance of blaCTX-M within an Australian Extended-Spectrum β-Lactamase Gene Pool Zhiyong Zong, Sally R. Partridge, Lee Thomas, and Jonathan R. Iredell Antimicrob. Agents Chemother. November 2008 52: 4198-4202; published ahead of print August 25, 2008, doi:10.1128/AAC.00107-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Genomewide Expression Profiling of Cryptolepine-Induced Toxicity in Saccharomyces cerevisiae Marta Rojas, Colin W. Wright, Benjamin Piña, and José Portugal Antimicrob. Agents Chemother. November 2008 52: 3844-3850; published ahead of print August 18, 2008, doi:10.1128/AAC.00532-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sitamaquine Sensitivity in Leishmania Species Is Not Mediated by Drug Accumulation in Acidocalcisomes Carmen López-Martín, José María Pérez-Victoria, Luis Carvalho, Santiago Castanys, and Francisco Gamarro Antimicrob. Agents Chemother. November 2008 52: 4030-4036; published ahead of print September 15, 2008, doi:10.1128/AAC.00964-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cloning, Expression, and Characterization of Babesia gibsoni Dihydrofolate Reductase-Thymidylate Synthase: Inhibitory Effect of Antifolates on Its Catalytic Activity and Parasite Proliferation Gabriel O. Aboge, Honglin Jia, Mohamad A. Terkawi, Youn-Kyoung Goo, Yoshifumi Nishikawa, Fujiko Sunaga, Kuzuhiko Namikawa, Naotoshi Tsuji, Ikuo Igarashi, Hiroshi Suzuki, Kozo Fujisaki, and Xuenan Xuan Antimicrob. Agents Chemother. November 2008 52: 4072-4080; published ahead of print September 15, 2008, doi:10.1128/AAC.00384-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Lactoferrin Induces Apoptosis-Like Cell Death in Candida albicans: Critical Role of K+-Channel-Mediated K+ Efflux María T. Andrés, Monica Viejo-Díaz, and José F. Fierro Antimicrob. Agents Chemother. November 2008 52: 4081-4088; published ahead of print August 18, 2008, doi:10.1128/AAC.01597-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Proposed MIC and Disk Diffusion Microbiological Cutoffs and Spectrum of Activity of Retapamulin, a Novel Topical Antimicrobial Agent Maria M. Traczewski and Steven D. Brown Antimicrob. Agents Chemother. November 2008 52: 3863-3867; published ahead of print August 25, 2008, doi:10.1128/AAC.00399-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antibacterial Activity of Vertilmicin and Its Susceptibility to Modifications by the Recombinant AAC(6')-APH(2'') Enzyme Cong-Ran Li, Xin-Yi Yang, Ren-Hui Lou, Wei-Xin Zhang, Yue-Ming Wang, Min Yuan, Yi Li, Hui-Zhen Chen, Bin Hong, Cheng-Hang Sun, Li-Xun Zhao, Zhuo-Rong Li, Jian-Dong Jiang, and Xue-Fu You Antimicrob. Agents Chemother. November 2008 52: 3875-3882; published ahead of print August 18, 2008, doi:10.1128/AAC.01400-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Evaluations of Oxacillin Efficiency against mecA-Positive Oxacillin-Susceptible Staphylococcus aureus Alexandros Ikonomidis, George Michail, Afroditi Vasdeki, Maria Labrou, Vasilis Karavasilis, Constantinos Stathopoulos, Antonios N. Maniatis, and Spyros Pournaras Antimicrob. Agents Chemother. November 2008 52: 3905-3908; published ahead of print August 11, 2008, doi:10.1128/AAC.00653-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mucroporin, the First Cationic Host Defense Peptide from the Venom of Lychas mucronatus Chao Dai, Yibao Ma, Zhenhuan Zhao, Ruiming Zhao, Qian Wang, Yingliang Wu, Zhijian Cao, and Wenxin Li Antimicrob. Agents Chemother. November 2008 52: 3967-3972; published ahead of print September 8, 2008, doi:10.1128/AAC.00542-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of ER-119884 and E5700, Two Potent Squalene Synthase Inhibitors, against Leishmania amazonensis: Antiproliferative, Biochemical, and Ultrastructural Effects Juliany Cola Fernandes Rodrigues, Juan Luis Concepcion, Carlos Rodrigues, Aura Caldera, Julio A. Urbina, and Wanderley de Souza Antimicrob. Agents Chemother. November 2008 52: 4098-4114; published ahead of print September 2, 2008, doi:10.1128/AAC.01616-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of OPT-80 Tested against Clinical Isolates of Toxin-Producing Clostridium difficile James A. Karlowsky, Nancy M. Laing, and George G. Zhanel Antimicrob. Agents Chemother. November 2008 52: 4163-4165; published ahead of print August 25, 2008, doi:10.1128/AAC.00476-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method Luis Ostrosky-Zeichner, John H. Rex, Michael A. Pfaller, Daniel J. Diekema, Barbara D. Alexander, David Andes, Steven D. Brown, Vishnu Chaturvedi, Mahmoud A. Ghannoum, Cindy C. Knapp, Daniel J. Sheehan, and Thomas J. Walsh Antimicrob. Agents Chemother. November 2008 52: 4175-4177; published ahead of print September 22, 2008, doi:10.1128/AAC.00420-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Tigecycline and 10 Other Antimicrobials against Nonpigmented Rapidly Growing Mycobacteria R. Fernández-Roblas, N. Z. Martín-de-Hijas, A. I. Fernández-Martínez, D. García-Almeida, I. Gadea, and J. Esteban Antimicrob. Agents Chemother. November 2008 52: 4184-4186; published ahead of print August 25, 2008, doi:10.1128/AAC.00695-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective Study of Fecal Colonization by Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Neutropenic Patients with Cancer L. Calatayud, M. Arnan, J. Liñares, M. A. Dominguez, C. Gudiol, J. Carratalà, M. Batlle, J. M. Ribera, and F. Gudiol Antimicrob. Agents Chemother. November 2008 52: 4187-4190; published ahead of print September 22, 2008, doi:10.1128/AAC.00367-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Synthesis, Antimalarial Activity, and Intracellular Targets of MEFAS, a New Hybrid Compound Derived from Mefloquine and Artesunate Fernando de Pilla Varotti, Ana Cristina C. Botelho, Anderson Assunção Andrade, Renata C. de Paula, Elaine M. S. Fagundes, Alessandra Valverde, Lúcia M. U. Mayer, Jorge Souza Mendonça, Marcus V. N. de Souza, Núbia Boechat, and Antoniana Ursine Krettli Antimicrob. Agents Chemother. November 2008 52: 3868-3874; published ahead of print August 18, 2008, doi:10.1128/AAC.00510-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Oseltamivir-Ribavirin Combination Therapy for Highly Pathogenic H5N1 Influenza Virus Infection in Mice Natalia A. Ilyushina, Alan Hay, Neziha Yilmaz, Adrianus C. M. Boon, Robert G. Webster, and Elena A. Govorkova Antimicrob. Agents Chemother. November 2008 52: 3889-3897; published ahead of print August 25, 2008, doi:10.1128/AAC.01579-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Virologic Response to Lopinavir-Ritonavir-Based Antiretroviral Regimens in a Multicenter International Clinical Cohort: Comparison of Genotypic Interpretation Scores Philip Grant, Eric C. Wong, Richard Rode, Robert Shafer, Andrea De Luca, Jeffrey Nadler, Trevor Hawkins, Calvin Cohen, Robert Harrington, Dale Kempf, and Andrew Zolopa Antimicrob. Agents Chemother. November 2008 52: 4050-4056; published ahead of print August 18, 2008, doi:10.1128/AAC.00605-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessing the Efficacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens M. Tempesta, G. Crescenzo, M. Camero, A. L. Bellacicco, E. Tarsitano, N. Decaro, J. Neyts, V. Martella, and C. Buonavoglia Antimicrob. Agents Chemother. November 2008 52: 4064-4068; published ahead of print September 2, 2008, doi:10.1128/AAC.00725-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potential for Hepatitis C Virus Resistance to Nitazoxanide or Tizoxanide Brent E. Korba, Menashe Elazar, Ping Lui, Jean-François Rossignol, and Jeffrey S. Glenn Antimicrob. Agents Chemother. November 2008 52: 4069-4071; published ahead of print August 18, 2008, doi:10.1128/AAC.00078-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Darunavir Inhibitory Quotient Predicts the 48-Week Virological Response to Darunavir-Based Salvage Therapy in Human Immunodeficiency Virus-Infected Protease Inhibitor-Experienced Patients José Moltó, José R. Santos, Nuria Pérez-Álvarez, Samandhy Cedeño, Cristina Miranda, Saye Khoo, Laura Else, Josep Maria Llibre, Marta Valle, and Bonaventura Clotet Antimicrob. Agents Chemother. November 2008 52: 3928-3932; published ahead of print August 25, 2008, doi:10.1128/AAC.00520-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Modeling of Aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: Identifying Dosing Regimens To Suppress Resistance Development Vincent H. Tam, Kimberly R. Ledesma, Giao Vo, Samer Kabbara, Tze-Peng Lim, and Michael Nikolaou Antimicrob. Agents Chemother. November 2008 52: 3987-3993; published ahead of print August 25, 2008, doi:10.1128/AAC.01468-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Effect of Protein Binding on the Pharmacological Activity of Highly Bound Antibiotics Stephan Schmidt, Katharina Röck, Martina Sahre, Olaf Burkhardt, Martin Brunner, Maximilian T. Lobmeyer, and Hartmut Derendorf Antimicrob. Agents Chemother. November 2008 52: 3994-4000; published ahead of print September 8, 2008, doi:10.1128/AAC.00427-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Repeated Administration of High-Dose Intermittent Rifapentine Reduces Rifapentine and Moxifloxacin Plasma Concentrations Kelly Dooley, Charles Flexner, Judith Hackman, Charles A. Peloquin, Eric Nuermberger, Richard E. Chaisson, and Susan E. Dorman Antimicrob. Agents Chemother. November 2008 52: 4037-4042; published ahead of print September 2, 2008, doi:10.1128/AAC.00554-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Fluconazole in Young Infants K. C. Wade, D. Wu, D. A. Kaufman, R. M. Ward, D. K. Benjamin, Jr., J. E. Sullivan, N. Ramey, B. Jayaraman, K. Hoppu, P. C. Adamson, M. R. Gastonguay, J. S. Barrett on behalf of the NICHD Pediatric Pharmacology Research Unit Network Antimicrob. Agents Chemother. November 2008 52: 4043-4049; published ahead of print September 22, 2008, doi:10.1128/AAC.00569-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Piperacillin-Tazobactam Penetration into Human Pancreatic Juice Elisa Bertazzoni Minelli, Anna Benini, Luigina Franco, Claudio Bassi, and Paolo Pederzoli Antimicrob. Agents Chemother. November 2008 52: 4149-4152; published ahead of print September 22, 2008, doi:10.1128/AAC.00509-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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In Vivo Microdialysis Study of the Penetration of Daptomycin into Soft Tissues in Diabetic versus Healthy Volunteers Aryun Kim, Larry A. Suecof, Christina A. Sutherland, Lihong Gao, Joseph L. Kuti, and David P. Nicolau Antimicrob. Agents Chemother. November 2008 52: 3941-3946; published ahead of print September 8, 2008, doi:10.1128/AAC.00589-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Voriconazole Metabolism by Chloramphenicol in an Adolescent with Central Nervous System Aspergillosis Verena Hafner, Nadine Albermann, Walter E. Haefeli, and Friedrich Ebinger Antimicrob. Agents Chemother. November 2008 52: 4172-4174; published ahead of print September 15, 2008, doi:10.1128/AAC.00805-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for Bacillus anthracis? G. L. Drusano, Olanrewaju O. Okusanya, Adedoyin Okusanya, Brian Van Scoy, D. L. Brown, Robert Kulawy, Fritz Sörgel, Henry S. Heine, and Arnold Louie Antimicrob. Agents Chemother. November 2008 52: 3973-3979; published ahead of print August 25, 2008, doi:10.1128/AAC.00453-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Therapeutic Chemical Agents In Vitro and on Experimental Meningoencephalitis Due to Naegleria fowleri Jong-Hyun Kim, Suk-Yul Jung, Yang-Jin Lee, Kyoung-Ju Song, Daeho Kwon, Kyongmin Kim, Sun Park, Kyung-Il Im, and Ho-Joon Shin Antimicrob. Agents Chemother. November 2008 52: 4010-4016; published ahead of print September 2, 2008, doi:10.1128/AAC.00197-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cerebrospinal Fluid and Plasma (13)-β-D-Glucan as Surrogate Markers for Detection and Monitoring of Therapeutic Response in Experimental Hematogenous Candida Meningoencephalitis Ruta Petraitiene, Vidmantas Petraitis, William W. Hope, Diana Mickiene, Amy M. Kelaher, Heidi A. Murray, Christine Mya-San, Johanna E. Hughes, Margaret P. Cotton, John Bacher, and Thomas J. Walsh Antimicrob. Agents Chemother. November 2008 52: 4121-4129; published ahead of print September 8, 2008, doi:10.1128/AAC.00674-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis Donald R. Hoff, Megan L. Caraway, Elizabeth J. Brooks, Emily R. Driver, Gavin J. Ryan, Charles A. Peloquin, Ian M. Orme, Randall J. Basaraba, and Anne J. Lenaerts Antimicrob. Agents Chemother. November 2008 52: 4137-4140; published ahead of print August 11, 2008, doi:10.1128/AAC.00196-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Single-Dose Liposomal Amphotericin B or Micafungin Prophylaxis in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis Russell E. Lewis, Nathaniel D. Albert, and Dimitrios P. Kontoyiannis Antimicrob. Agents Chemother. November 2008 52: 4178-4180; published ahead of print August 25, 2008, doi:10.1128/AAC.00715-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Statins Alone Are Ineffective in Cerebral Malaria but Potentiate Artesunate Anne-Lise Bienvenu and Stéphane Picot Antimicrob. Agents Chemother. November 2008 52: 4203-4204; published ahead of print September 8, 2008, doi:10.1128/AAC.00513-08 [Full Text] [PDF] [Reprints and Permissions]

Carbapenem-Resistant Acinetobacter baumannii Isolates Expressing the blaOXA-23 Gene Associated with ISAba4 in Belgium Pierre Bogaerts, Gaelle Cuzon, Thierry Naas, Caroline Bauraing, Ariane Deplano, Bénédicte Lissoir, Patrice Nordmann, and Youri Glupczynski Antimicrob. Agents Chemother. November 2008 52: 4205-4206; published ahead of print September 2, 2008, doi:10.1128/AAC.01121-08 [Full Text] [PDF] [Reprints and Permissions]

Improved Antimicrobial Activity of Linezolid against Vancomycin-Intermediate Staphylococcus aureus Yukiko Watanabe, Hui-min Neoh, Longzhu Cui, and Keiichi Hiramatsu Antimicrob. Agents Chemother. November 2008 52: 4207-4208; published ahead of print August 18, 2008, doi:10.1128/AAC.00676-08 [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Ceftaroline against Streptococcus pneumoniae Isolates Exhibiting Resistance to Penicillin, Amoxicillin, and Cefotaxime Asunción Fenoll, Lorenzo Aguilar, Olga Robledo, María-José Giménez, Juan-José Granizo, Donald Biek, and David Tarragó Antimicrob. Agents Chemother. November 2008 52: 4209-4210; published ahead of print August 25, 2008, doi:10.1128/AAC.00712-08 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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In Vitro Antifungal Activities of Isavuconazole (BAL4815), Voriconazole, and Fluconazole against 1,007 Isolates of Zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium Species Jesús Guinea, Teresa Peláez, Sandra Recio, Marta Torres-Narbona, and Emilio Bouza Antimicrob. Agents Chemother. November 2008 52: 4211 [Full Text] [PDF] [Reprints and Permissions]

Effects of Lipid-Based Oral Formulations on Plasma and Tissue Amphotericin B Concentrations and Renal Toxicity in Male Rats Verica Risovic, Michael Boyd, Eugene Choo, and Kishor M. Wasan Antimicrob. Agents Chemother. November 2008 52: 4212 [Full Text] [PDF] [Reprints and Permissions]

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