Contents: March 2008, Volume 52, Issue 3        Minireviews        Mechanisms of Resistance        Experimental Therapeutics        Clinical Therapeutics        Pharmacology        Antiviral Agents        Mechanisms of Action        Susceptibility        Analytical Procedures        Biologic Response Modifiers        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Clinical and Economic Impact of Common Multidrug-Resistant Gram-Negative Bacilli Christian G. Giske, Dominique L. Monnet, Otto Cars, Yehuda Carmeli on behalf of ReAct-Action on Antibiotic Resistance Antimicrob. Agents Chemother. March 2008 52: 813-821; published ahead of print December 10, 2007, doi:10.1128/AAC.01169-07 [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Fitness of Streptococcus pneumoniae Fluoroquinolone-Resistant Strains with Topoisomerase IV Recombinant Genes Luz Balsalobre and Adela G. de la Campa Antimicrob. Agents Chemother. March 2008 52: 822-830; published ahead of print December 26, 2007, doi:10.1128/AAC.00731-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Characteristics of Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains Belonging to Multilocus Sequence Type 59 in Taiwan Tomomi Takano, Wataru Higuchi, Taketo Otsuka, Tatiana Baranovich, Shymaa Enany, Kohei Saito, Hirokazu Isobe, Soshi Dohmae, Kyoko Ozaki, Misao Takano, Yasuhisa Iwao, Michiko Shibuya, Takeshi Okubo, Shizuka Yabe, Da Shi, Ivan Reva, Lee-Jene Teng, and Tatsuo Yamamoto Antimicrob. Agents Chemother. March 2008 52: 837-845; published ahead of print December 17, 2007, doi:10.1128/AAC.01001-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Induction of erm(C) Expression by Noninducing Antibiotics Marne Bailey, Tobin Chettiath, and Alexander S. Mankin Antimicrob. Agents Chemother. March 2008 52: 866-874; published ahead of print December 17, 2007, doi:10.1128/AAC.01266-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum β-Lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates Mariagrazia Perilli, Giuseppe Celenza, Francesca De Santis, Cristina Pellegrini, Chiara Forcella, Gian Maria Rossolini, Stefania Stefani, and Gianfranco Amicosante Antimicrob. Agents Chemother. March 2008 52: 915-919; published ahead of print December 26, 2007, doi:10.1128/AAC.01028-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increase of Virulence and Its Phenotypic Traits in Drug-Resistant Strains of Candida albicans Letizia Angiolella, Anna Rita Stringaro, Flavia De Bernardis, Brunella Posteraro, Mariantonietta Bonito, Laura Toccacieli, Antonella Torosantucci, Marisa Colone, Maurizio Sanguinetti, Antonio Cassone, and Anna Teresa Palamara Antimicrob. Agents Chemother. March 2008 52: 927-936; published ahead of print January 7, 2008, doi:10.1128/AAC.01223-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Antibiotic Resistance during Therapy for Infections Caused by Enterobacteriaceae Producing AmpC β-Lactamase: Implications for Antibiotic Use Sang-Ho Choi, Jung Eun Lee, Su Jin Park, Seong-Ho Choi, Sang-Oh Lee, Jin-Yong Jeong, Mi-Na Kim, Jun Hee Woo, and Yang Soo Kim Antimicrob. Agents Chemother. March 2008 52: 995-1000; published ahead of print December 17, 2007, doi:10.1128/AAC.01083-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of Tn1546 and Its Role in the Dissemination of Vancomycin-Resistant Enterococci in Portugal Carla Novais, Ana R. Freitas, João C. Sousa, Fernando Baquero, Teresa M. Coque, and Luísa V. Peixe Antimicrob. Agents Chemother. March 2008 52: 1001-1008; published ahead of print January 7, 2008, doi:10.1128/AAC.00999-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Highly Variable Penicillin Resistance Determinants PBP 2x, PBP 2b, and PBP 1a in Isolates of Two Streptococcus pneumoniae Clonal Groups, Poland23F-16 and Poland6B-20 Radoslaw Izdebski, Jens Rutschmann, Janusz Fiett, Ewa Sadowy, Marek Gniadkowski, Waleria Hryniewicz, and Regine Hakenbeck Antimicrob. Agents Chemother. March 2008 52: 1021-1027; published ahead of print December 26, 2007, doi:10.1128/AAC.01082-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Conserved Water Molecules Stabilize the -Loop in Class A β-Lactamases Fabian Bös and Jürgen Pleiss Antimicrob. Agents Chemother. March 2008 52: 1072-1079; published ahead of print January 14, 2008, doi:10.1128/AAC.01035-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Inhibition of ABC Transporters Abolishes Antimony Resistance in Leishmania Infection Jayati Mookerjee Basu, Ananda Mookerjee, Rajdeep Banerjee, Manik Saha, Subhankar Singh, Ksudiram Naskar, Gayetri Tripathy, Prabhat K. Sinha, Krishna Pandey, Shyam Sundar, Sanjeev Bimal, Pradip K. Das, Soumitra K. Choudhuri, and Syamal Roy Antimicrob. Agents Chemother. March 2008 52: 1080-1093; published ahead of print December 3, 2007, doi:10.1128/AAC.01196-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds Fiona L. Henriquez, Paul R. Ingram, Stephen P. Muench, David W. Rice, and Craig W. Roberts Antimicrob. Agents Chemother. March 2008 52: 1133-1135; published ahead of print December 10, 2007, doi:10.1128/AAC.00355-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Plasmid-Borne erm(T) from Invasive, Macrolide-Resistant Streptococcus pyogenes Strains Robyn L. Woodbury, Kathryn A. Klammer, Yang Xiong, Timothy Bailiff, Anita Glennen, Joanne M. Bartkus, Ruth Lynfield, Chris Van Beneden, Bernard W. Beall for the Active Bacterial Core Surveillance Team Antimicrob. Agents Chemother. March 2008 52: 1140-1143; published ahead of print January 7, 2008, doi:10.1128/AAC.01352-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin Jason M. Cota, Jodi L. Grabinski, Robert L. Talbert, David S. Burgess, P. David Rogers, Thomas D. Edlind, and Nathan P. Wiederhold Antimicrob. Agents Chemother. March 2008 52: 1144-1146; published ahead of print December 17, 2007, doi:10.1128/AAC.01542-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection for High-Level Telithromycin Resistance in Staphylococcus aureus Yields Mutants Resulting from an rplB-to-rplV Gene Conversion-Like Event Daniel R. Gentry and David J. Holmes Antimicrob. Agents Chemother. March 2008 52: 1156-1158; published ahead of print January 14, 2008, doi:10.1128/AAC.00923-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Resistance to Daptomycin in Enterococcus faecium Clemente I. Montero, Frida Stock, and Patrick R. Murray Antimicrob. Agents Chemother. March 2008 52: 1167-1170; published ahead of print January 7, 2008, doi:10.1128/AAC.00774-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Antibiotic Use and Incidence of MexXY-OprM Overproducers among Clinical Isolates of Pseudomonas aeruginosa Didier Hocquet, Arno Muller, Karine Blanc, Patrick Plésiat, Daniel Talon, Dominique Louis Monnet, and Xavier Bertrand Antimicrob. Agents Chemother. March 2008 52: 1173-1175; published ahead of print January 7, 2008, doi:10.1128/AAC.01212-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increasing Genetic Relatedness of Ciprofloxacin-Resistant Streptococcus pneumoniae Isolated in Canada from 1997 to 2005 Kimberly A. Nichol, Heather J. Adam, James A. Karlowsky, George G. Zhanel, and Daryl J. Hoban Antimicrob. Agents Chemother. March 2008 52: 1190-1194; published ahead of print January 7, 2008, doi:10.1128/AAC.01260-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Rates of Fecal Carriage of Nonenterococcal vanB in both Children and Adults M. Graham, S. A. Ballard, E. A. Grabsch, P. D. R. Johnson, and M. L. Grayson Antimicrob. Agents Chemother. March 2008 52: 1195-1197; published ahead of print January 7, 2008, doi:10.1128/AAC.00531-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Induction of L1 and L2 β-Lactamases of Stenotrophomonas maltophilia Rouh-Mei Hu, Kuang-Jay Huang, Lii-Tzu Wu, Ying-Ju Hsiao, and Tsuey-Ching Yang Antimicrob. Agents Chemother. March 2008 52: 1198-1200; published ahead of print December 17, 2007, doi:10.1128/AAC.00682-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone-Resistant Mutants of Burkholderia cepacia C. F. Pope, S. H. Gillespie, J. R. Pratten, and T. D. McHugh Antimicrob. Agents Chemother. March 2008 52: 1201-1203; published ahead of print December 26, 2007, doi:10.1128/AAC.00799-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Daptomycin Activity against Staphylococcus aureus following Vancomycin Exposure in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations Warren E. Rose, Steven N. Leonard, George Sakoulas, Glenn W. Kaatz, Marcus J. Zervos, Anjly Sheth, Christopher F. Carpenter, and Michael J. Rybak Antimicrob. Agents Chemother. March 2008 52: 831-836; published ahead of print November 12, 2007, doi:10.1128/AAC.00869-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Treatment of Experimental Anthrax with Recombinant Capsule Depolymerase Angelo Scorpio, Steven A. Tobery, Wilson J. Ribot, and Arthur M. Friedlander Antimicrob. Agents Chemother. March 2008 52: 1014-1020; published ahead of print December 26, 2007, doi:10.1128/AAC.00741-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin Jurjen S. Lagas, Rolf W. Sparidans, Robert A. B. van Waterschoot, Els Wagenaar, Jos H. Beijnen, and Alfred H. Schinkel Antimicrob. Agents Chemother. March 2008 52: 1034-1039; published ahead of print January 14, 2008, doi:10.1128/AAC.01041-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isolation and Purification of Enterocin E-760 with Broad Antimicrobial Activity against Gram-Positive and Gram-Negative Bacteria J. E. Line, E. A. Svetoch, B. V. Eruslanov, V. V. Perelygin, E. V. Mitsevich, I. P. Mitsevich, V. P. Levchuk, O. E. Svetoch, B. S. Seal, G. R. Siragusa, and N. J. Stern Antimicrob. Agents Chemother. March 2008 52: 1094-1100; published ahead of print December 17, 2007, doi:10.1128/AAC.01569-06 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium difficile-Associated Diarrhea and Prevention of Disease Recurrence in Hamsters Efi Kokkotou, Alan C. Moss, Athanasios Michos, Daniel Espinoza, Jeffrey W. Cloud, Nasima Mustafa, Michael O'Brien, Charalabos Pothoulakis, and Ciarán P. Kelly Antimicrob. Agents Chemother. March 2008 52: 1121-1126; published ahead of print January 14, 2008, doi:10.1128/AAC.01143-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens Stephanie J. Wallace, Jian Li, Roger L. Nation, Craig R. Rayner, David Taylor, Deborah Middleton, Robert W. Milne, Kingsley Coulthard, and John D. Turnidge Antimicrob. Agents Chemother. March 2008 52: 1159-1161; published ahead of print January 7, 2008, doi:10.1128/AAC.01101-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessment of Serum (13)-β-D-Glucan Concentration as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis Nathan P. Wiederhold, Laura K. Najvar, Ana C. Vallor, William R. Kirkpatrick, Rosie Bocanegra, Destiny Molina, Marcos Olivo, John R. Graybill, and Thomas F. Patterson Antimicrob. Agents Chemother. March 2008 52: 1176-1178; published ahead of print December 26, 2007, doi:10.1128/AAC.01425-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Risk Factors for Trimethoprim-Sulfamethoxazole Resistance in Patients with Acute Uncomplicated Cystitis Richard Colgan, James R. Johnson, Michael Kuskowski, and Kalpana Gupta Antimicrob. Agents Chemother. March 2008 52: 846-851; published ahead of print December 17, 2007, doi:10.1128/AAC.01200-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Predictors of Carbapenem-Resistant Klebsiella pneumoniae Acquisition among Hospitalized Adults and Effect of Acquisition on Mortality Mitchell J. Schwaber, Shiri Klarfeld-Lidji, Shiri Navon-Venezia, David Schwartz, Azita Leavitt, and Yehuda Carmeli Antimicrob. Agents Chemother. March 2008 52: 1028-1033; published ahead of print December 17, 2007, doi:10.1128/AAC.01020-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Population Pharmacokinetics of Levofloxacin, Gatifloxacin, and Moxifloxacin in Adults with Pulmonary Tuberculosis Charles A. Peloquin, David Jamil Hadad, Lucilia Pereira Dutra Molino, Moises Palaci, W. Henry Boom, Reynaldo Dietze, and John L. Johnson Antimicrob. Agents Chemother. March 2008 52: 852-857; published ahead of print December 10, 2007, doi:10.1128/AAC.01036-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism-Based Pharmacokinetic-Pharmacodynamic Models of In Vitro Fungistatic and Fungicidal Effects against Candida albicans Nicolas Venisse, Nicolas Grégoire, Manuella Marliat, and William Couet Antimicrob. Agents Chemother. March 2008 52: 937-943; published ahead of print January 7, 2008, doi:10.1128/AAC.01030-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Induction of the Carrier State in Pigeons Infected with Salmonella enterica Subspecies enterica Serovar Typhimurium PT99 by Treatment with Florfenicol: a Matter of Pharmacokinetics Frank Pasmans, Kris Baert, An Martel, Alain Bousquet-Melou, Ruben Lanckriet, Sandra De Boever, Filip Van Immerseel, Venessa Eeckhaut, Patrick de Backer, and Freddy Haesebrouck Antimicrob. Agents Chemother. March 2008 52: 954-961; published ahead of print January 7, 2008, doi:10.1128/AAC.00575-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Adsorption of Amikacin, a Significant Mechanism of Elimination by Hemofiltration Qi Tian, Charles D. Gomersall, Margaret Ip, Perpetua E. Tan, Gavin M. Joynt, and Gordon Y. S. Choi Antimicrob. Agents Chemother. March 2008 52: 1009-1013; published ahead of print December 17, 2007, doi:10.1128/AAC.00858-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Escherichia coli Lipopolysaccharide on Telithromycin Pharmacokinetics in Rats: Inhibition of Metabolism via CYP3A Joo H. Lee, Yu K. Cho, Young S. Jung, Young C. Kim, and Myung G. Lee Antimicrob. Agents Chemother. March 2008 52: 1046-1051; published ahead of print December 26, 2007, doi:10.1128/AAC.01210-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand J. Tarning, E. A. Ashley, N. Lindegardh, K. Stepniewska, L. Phaiphun, N. P. J. Day, R. McGready, M. Ashton, F. Nosten, and N. J. White Antimicrob. Agents Chemother. March 2008 52: 1052-1061; published ahead of print January 7, 2008, doi:10.1128/AAC.00955-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Systemic Pharmacokinetics of Rifaximin in Volunteers with Shigellosis David N. Taylor, Robin McKenzie, Anna Durbin, Colleen Carpenter, Robert Haake, and A. Louis Bourgeois Antimicrob. Agents Chemother. March 2008 52: 1179-1181; published ahead of print December 17, 2007, doi:10.1128/AAC.01108-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil David Sevillano, Lorenzo Aguilar, Luis Alou, María-José Giménez, Martha Torrico, Natalia González, Fabio Cafini, María-Teresa Relaño, Pilar Coronel, and José Prieto Antimicrob. Agents Chemother. March 2008 52: 1184-1186; published ahead of print December 26, 2007, doi:10.1128/AAC.01247-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Hepatotoxicity Observed in Clinical Trials of Aplaviroc (GW873140) W. G. Nichols, H. M. Steel, T. Bonny, K. Adkison, L. Curtis, J. Millard, K. Kabeya, and N. Clumeck Antimicrob. Agents Chemother. March 2008 52: 858-865; published ahead of print December 10, 2007, doi:10.1128/AAC.00821-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral Edward P. Garvey, Brian A. Johns, Margaret J. Gartland, Scott A. Foster, Wayne H. Miller, Robert G. Ferris, Richard J. Hazen, Mark R. Underwood, Eric E. Boros, James B. Thompson, Jason G. Weatherhead, Cecilia S. Koble, Scott H. Allen, Lee T. Schaller, Ronald G. Sherrill, Tomokazu Yoshinaga, Masanori Kobayashi, Chiaki Wakasa-Morimoto, Shigeru Miki, Koichiro Nakahara, Takeshi Noshi, Akihiko Sato, and Tamio Fujiwara Antimicrob. Agents Chemother. March 2008 52: 901-908; published ahead of print December 26, 2007, doi:10.1128/AAC.01218-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Concentrations of Dapivirine in the Rhesus Macaque and Rabbit following Once Daily Intravaginal Administration of a Gel Formulation of [14C]Dapivirine for 7 Days Jeremy P. Nuttall, Daryl C. Thake, Mark G. Lewis, John W. Ferkany, Joseph W. Romano, and Mark A. Mitchnick Antimicrob. Agents Chemother. March 2008 52: 909-914; published ahead of print December 17, 2007, doi:10.1128/AAC.00330-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus Charles E. Isaacs, Guang Y. Wen, Weimin Xu, Jun Hua Jia, Lisa Rohan, Christopher Corbo, Vincenzo Di Maggio, Edmund C. Jenkins, Jr., and Sharon Hillier Antimicrob. Agents Chemother. March 2008 52: 962-970; published ahead of print January 14, 2008, doi:10.1128/AAC.00825-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues Jason D. Graci, Kathleen Too, Eric D. Smidansky, Jocelyn P. Edathil, Eric W. Barr, Daniel A. Harki, Jessica E. Galarraga, J. Martin Bollinger, Jr., Blake R. Peterson, David Loakes, Daniel M. Brown, and Craig E. Cameron Antimicrob. Agents Chemother. March 2008 52: 971-979; published ahead of print January 7, 2008, doi:10.1128/AAC.01056-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Tipranavir (TPV) Genotypic Inhibitory Quotient Predicts Virological Response at 48 Weeks to TPV-Based Salvage Regimens Daniel Gonzalez de Requena, Stefano Bonora, Andrea Calcagno, Antonio D'Avolio, Marco Siccardi, Silvia Fontana, Maria Grazia Milia, Mauro Sciandra, Silvia Garazzino, Antonio Di Garbo, Lorena Baietto, Laura Trentini, and Giovanni Di Perri Antimicrob. Agents Chemother. March 2008 52: 1066-1071; published ahead of print December 26, 2007, doi:10.1128/AAC.01063-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System Yupeng He, Martin S. King, Dale J. Kempf, Liangjun Lu, Hock Ben Lim, Preethi Krishnan, Warren Kati, Timothy Middleton, and Akhteruzzaman Molla Antimicrob. Agents Chemother. March 2008 52: 1101-1110; published ahead of print December 17, 2007, doi:10.1128/AAC.01149-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phosphorothioate-Modified Oligodeoxynucleotides Inhibit Human Cytomegalovirus Replication by Blocking Virus Entry Anna Luganini, Patrizia Caposio, Santo Landolfo, and Giorgio Gribaudo Antimicrob. Agents Chemother. March 2008 52: 1111-1120; published ahead of print January 7, 2008, doi:10.1128/AAC.00987-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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The Mitochondrion Is a Site of Trypanocidal Action of the Aromatic Diamidine DB75 in Bloodstream Forms of Trypanosoma brucei Charlotte A. Lanteri, Richard R. Tidwell, and Steven R. Meshnick Antimicrob. Agents Chemother. March 2008 52: 875-882; published ahead of print December 17, 2007, doi:10.1128/AAC.00642-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Macrophage Inflammatory Protein 3: Protein and Peptide Nuclear Magnetic Resonance Solution Structures, Dimerization, Dynamics, and Anti-Infective Properties David I. Chan, Howard N. Hunter, Brian F. Tack, and Hans J. Vogel Antimicrob. Agents Chemother. March 2008 52: 883-894; published ahead of print December 17, 2007, doi:10.1128/AAC.00805-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Aminoglycosides Affect Intracellular Salmonella enterica Serovars Typhimurium and Virchow Ofir Menashe, Elena Kaganskaya, Timor Baasov, and Sima Yaron Antimicrob. Agents Chemother. March 2008 52: 920-926; published ahead of print January 2, 2008, doi:10.1128/AAC.00382-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Microbicidal Properties and Cytocidal Selectivity of Rhesus Macaque Theta Defensins Dat Tran, Patti Tran, Kevin Roberts, George Ösapay, Justin Schaal, Andre Ouellette, and Michael E. Selsted Antimicrob. Agents Chemother. March 2008 52: 944-953; published ahead of print December 26, 2007, doi:10.1128/AAC.01090-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transcriptional Profiling Reveals that Daptomycin Induces the Staphylococcus aureus Cell Wall Stress Stimulon and Genes Responsive to Membrane Depolarization Arunachalam Muthaiyan, Jared A. Silverman, Radheshyam K. Jayaswal, and Brian J. Wilkinson Antimicrob. Agents Chemother. March 2008 52: 980-990; published ahead of print December 17, 2007, doi:10.1128/AAC.01121-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms Priya Uppuluri, Jeniel Nett, Joseph Heitman, and David Andes Antimicrob. Agents Chemother. March 2008 52: 1127-1132; published ahead of print January 7, 2008, doi:10.1128/AAC.01397-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimycobacterial Activity and Mechanism of Action of NAS-91 Paul Gratraud, Namita Surolia, Gurdyal S. Besra, Avadhesha Surolia, and Laurent Kremer Antimicrob. Agents Chemother. March 2008 52: 1162-1166; published ahead of print December 17, 2007, doi:10.1128/AAC.00968-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Enhanced Production of Phospholipase C and Perfringolysin O (Alpha and Theta Toxins) in a Gatifloxacin-Resistant Strain of Clostridium perfringens Fatemeh Rafii, Miseon Park, Amy E. Bryant, Shemedia J. Johnson, and Robert D. Wagner Antimicrob. Agents Chemother. March 2008 52: 895-900; published ahead of print December 26, 2007, doi:10.1128/AAC.01316-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Susceptibility of Proteus mirabilis to Triclosan David J. Stickler and Gwennan L. Jones Antimicrob. Agents Chemother. March 2008 52: 991-994; published ahead of print January 7, 2008, doi:10.1128/AAC.01094-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determinants of In Vitro Drug Susceptibility Testing of Plasmodium vivax B. Russell, F. Chalfein, B. Prasetyorini, E. Kenangalem, K. Piera, R. Suwanarusk, A. Brockman, P. Prayoga, P. Sugiarto, Q. Cheng, E. Tjitra, N. M. Anstey, and R. N. Price Antimicrob. Agents Chemother. March 2008 52: 1040-1045; published ahead of print January 7, 2008, doi:10.1128/AAC.01334-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of 35 Double Combinations of Antifungal Agents against Scedosporium apiospermum and Scedosporium prolificans Manuel Cuenca-Estrella, Ana Alastruey-Izquierdo, Laura Alcazar-Fuoli, Leticia Bernal-Martinez, Alicia Gomez-Lopez, Maria J. Buitrago, Emilia Mellado, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. March 2008 52: 1136-1139; published ahead of print January 14, 2008, doi:10.1128/AAC.01160-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America Roseanne A. Ressner, Matthew R. Moore, and James H. Jorgensen Antimicrob. Agents Chemother. March 2008 52: 1147-1149; published ahead of print January 7, 2008, doi:10.1128/AAC.01387-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bobel-24 Activity against Cryptosporidium parvum in Cell Culture and in a SCID Mouse Model Cristina Rueda, Soledad Fenoy, Fernando Simón, and Carmen del Aguila Antimicrob. Agents Chemother. March 2008 52: 1150-1152; published ahead of print December 26, 2007, doi:10.1128/AAC.01019-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activities of Ceftaroline and ME1036 Tested against Clinical Strains of Community-Acquired Methicillin-Resistant Staphylococcus aureus Helio S. Sader, Thomas R. Fritsche, and Ronald N. Jones Antimicrob. Agents Chemother. March 2008 52: 1153-1155; published ahead of print January 7, 2008, doi:10.1128/AAC.01351-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of AR-709 against Streptococcus pneumoniae W. T. M. Jansen, A. Verel, J. Verhoef, and D. Milatovic Antimicrob. Agents Chemother. March 2008 52: 1182-1183; published ahead of print January 7, 2008, doi:10.1128/AAC.01332-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections Thomas R. Fritsche, Paul R. Rhomberg, Helio S. Sader, and Ronald N. Jones Antimicrob. Agents Chemother. March 2008 52: 1187-1189; published ahead of print January 7, 2008, doi:10.1128/AAC.01475-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Reliability of the WIDERYST Susceptibility Testing System for Detection of In Vitro Antifungal Resistance in Yeasts Manuel Cuenca-Estrella, Alicia Gomez-Lopez, M. Olga Gutierrez, M. Jose Buitrago, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. March 2008 52: 1062-1065; published ahead of print January 14, 2008, doi:10.1128/AAC.01016-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Dectin-1 Fc Targeting of Aspergillus fumigatus Beta-Glucans Augments Innate Defense against Invasive Pulmonary Aspergillosis Polly E. Mattila, Allison E. Metz, Rekha R. Rapaka, Lynne D. Bauer, and Chad Steele Antimicrob. Agents Chemother. March 2008 52: 1171-1172; published ahead of print December 17, 2007, doi:10.1128/AAC.01274-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Escherichia coli Isolate Coproducing 16S rRNA Methylase and CTX-M-Type Extended-Spectrum β-Lactamase Isolated from an Outpatient in the United States Yohei Doi, Jennifer M. Adams-Haduch, and David L. Paterson Antimicrob. Agents Chemother. March 2008 52: 1204-1205; published ahead of print January 14, 2008, doi:10.1128/AAC.01320-07 [Full Text] [PDF] [Reprints and Permissions]

Novel Variant of the qnrB Gene, qnrB12, in Citrobacter werkmanii Corinna Kehrenberg, Sonja Friederichs, Anno de Jong, and Stefan Schwarz Antimicrob. Agents Chemother. March 2008 52: 1206-1207; published ahead of print December 17, 2007, doi:10.1128/AAC.01042-07 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Thiopurine Drugs Azathioprine and 6-Mercaptopurine Inhibit Mycobacterium paratuberculosis Growth In Vitro Sung Jae Shin and Michael T. Collins Antimicrob. Agents Chemother. March 2008 52: 1208 [Full Text] [PDF] [Reprints and Permissions]

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